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Abid Oueslati
Professeur titulaire
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de médecine :
Neurosciences et santé mentale
Domaines et intérêts de recherche du (de la) professeur(e) :
Neurosciences, santé mentale et toxicomanies
- Chorée de Huntington
- Maladie d'Alzheimer
- Maladie de Parkinson
- Maladies neurodégénératives
Projets de recherche
- Deciphering the physiological role of alpha-synuclein aggregation in the central nervous system - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2023-04-01 au 2028-03-31
- Exploring the synergistic role of alpha-synuclein and tau in Alzheimer’s disease pathogenesis - Société Alzheimer du Canada - Proof of Concept Grants, chercheur principal - 2023-10-01 au 2026-09-30
- Investigation of the synergistic role of TMEM106B and alpha-synuclein in Parkinson’s disease pathogenesis - Parkinson Canada - Pilot Project Grant, chercheur principal - 2023-08-01 au 2024-07-31
- Implication de l’alpha-synucléine dans la pathogenèse et les traitements de la maladie de Parkinson - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2020-07-01 au 2024-06-30
- Unveiling the role of alpha-synuclein clustering and Lewy body formation in Parkinson’s disease pathogenesis using an optogenetic-mediated protein aggregation system - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-04-01 au 2024-03-31
- Effects of post-translational modifications on intracellular alpha-synuclein oligomerization - Michael J. Fox Foundation for Parkinson's Research, Purdue University, co-chercheur - 2023-02-01 au 2024-01-31
- Use of optogenetic-TDP43 to shed light on the dying-back hypothesis in ALS - Université Laval - Fonds internes - BDR - Contributions, co-chercheur - 2022-04-01 au 2023-03-31
- Investigation of the synergistic role of PLK2 and alpha-synuclein in the regulation of neuronal homeostasis and functions. - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31
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Publications
- Dissecting the Molecular Pathway Involved in PLK2 Kinase-mediated α-Synuclein-selective Autophagic Degradation., , The Journal of biological chemistry, 2017, 10.1074/jbc.M116.759373
- c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease., , Human molecular genetics, 2014, 10.1093/hmg/ddt674
- The many faces of α-synuclein: from structure and toxicity to therapeutic target., , Nature reviews. Neuroscience, 2013, 10.1038/nrn3406
- The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity., , The Journal of biological chemistry, 2014, 10.1074/jbc.M114.553297
- Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies., , Progress in brain research, 2010, 10.1016/s0079-6123(10)83007-9
- Dysfunction of the cortico-basal ganglia-cortical loop in a rat model of early parkinsonism is reversed by metabotropic glutamate receptor 5 antagonism., , The European journal of neuroscience, 2005, 10.1111/j.1460-9568.2005.04498.x
- Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons, Abid Oueslati, Walid Idi, Maxime Teixeira, Razan Sheta, STAR Protocols, 2023, 10.1016/j.xpro.2023.102486
- Optogenetic-Mediated Spatiotemporal Control of α-Synuclein Aggregation Disrupts Nigrostriatal Transmission and Precipitates Neurodegeneration, , SSRN Electronic Journal, 2019, 10.2139/ssrn.3416893
- The combination of optogenetic-induced protein aggregation and proximity biotinylation assays strongly implicates endolysosomal proteins in the early stages of α-synuclein aggregation, Abid Oueslati, Jean-Phillippe Lambert, Jérémy Loehr, Vetso Ranjakasoa, Dylan Musiol, Razan Sheta, Maxime Teixeira, 2024, 10.1101/2024.10.16.618762
- Human-to-mouse prion-like propagation of mutant huntingtin protein., , Acta neuropathologica, 2016, 10.1007/s00401-016-1582-9
- Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease., , PloS one, 2015, 10.1371/journal.pone.0140880
- Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo., , The Journal of biological chemistry, 2015, 10.1074/jbc.M114.610774
- Pharmacological inhibition of PLK2 kinase activity mitigates cognitive decline but aggravates APP pathology in a sex-dependent manner in APP/PS1 mouse model of Alzheimer's disease, Abid Oueslati, Serge Rivest, Dylan Musiol, Morgan Bérard, Laura Martínez-Drudis, Heliyon, 2024, 10.1016/j.heliyon.2024.e39571
- High-frequency stimulation of the subthalamic nucleus potentiates L-DOPA-induced neurochemical changes in the striatum in a rat model of Parkinson's disease., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/JNEUROSCI.2949-06.2007
- Phosphorylation of synucleins by members of the Polo-like kinase family., , The Journal of biological chemistry, 2009, 10.1074/jbc.M109.081950
- Different functional basal ganglia subcircuits associated with anti-akinetic and dyskinesiogenic effects of antiparkinsonian therapies., , Neurobiology of disease, 2009, 10.1016/j.nbd.2009.07.002
- Optogenetic-mediated induction and monitoring of α-synuclein aggregation in cellular models of Parkinson’s disease, Abid Oueslati, Walid Idi, Razan Sheta, Maxime Teixeira, STAR Protocols, 2023, 10.1016/j.xpro.2023.102738
- Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo., , Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1309991110
- Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation., , Experimental neurobiology, 2014, 10.5607/en.2014.23.4.324
- Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?, , Journal of Parkinson's disease, 2016, 10.3233/JPD-160779
- Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains, Abid Oueslati, Omar M. A. El-Agnaf, Razan Sheta, Laura Martínez-Drudis, Morgan Bérard, Molecular Neurodegeneration, 2023, 10.1186/s13024-023-00683-8
- Chronic high-frequency stimulation of the subthalamic nucleus and L-DOPA treatment in experimental parkinsonism: effects on motor behaviour and striatal glutamate transmission., , The European journal of neuroscience, 2006, 10.1111/j.1460-9568.2006.05047.x
- Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, 10.1523/JNEUROSCI.3784-11.2012
- Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease., , Proceedings of the National Academy of Sciences of the United States of America, 2016, 10.1073/pnas.1512876113
- Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 10.1523/JNEUROSCI.5922-09.2010
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Walid Idi - Doctorat - En cours
- Dylan Musiol - Doctorat - En cours
- Shanna Pigeyre - Maîtrise avec mémoire - En cours
- Raquel Rodríguez Aller - Doctorat - En cours
- Maxime Teixeira - Doctorat - En cours
- Morgan Bérard - Maîtrise avec mémoire - 2020/01
- Rémi Pellegrinato - Maîtrise avec mémoire - 2022/01
- Laura Martínez Drudis - Doctorat - 2024/09
Encadrement d'étudiant(e)s
Direction de recherche dans les domaines suivants :
- Médecine moléculaire
- Neurobiologie — Neurosciences
En savoir plus sur les programmes
Disponibilité d'encadrement d'étudiant(e)s
Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.
Envoyer un courriel*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.