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Alexandre Bureau

Professeur titulaire

Alexandre Bureau
Alexandre.Bureau@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche CERVO
Centre de recherche en données massives
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Neurosciences et santé mentale
Reproduction, génétique, périnatalité et développement
Santé des populations et pratiques optimales en santé

Domaines et intérêts de recherche du (de la) professeur(e) :

Génétique humaine
  • Cartographie génétique
  • Interactions gènes et environnement
  • Génétique de traits complexes
  • Micropuces d'ADN et d'ARN
  • Génomique
Neurosciences, santé mentale et toxicomanies
  • Génétique des maladies neurologiques et psychiatriques
  • Schizophrénie
  • Troubles affectifs (de l'humeur)
Santé des populations
  • Prévention en santé
Statistiques et probabilités
  • Inférence paramétrique et non paramétrique
  • Statistique informatique

Projets de recherche

  • Improving detection and interpretation of noncoding variants in familial genetic studies - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2024-04-01 au 2029-03-31
  • Centre de recherches mathématiques (CRM) - Université Laval - Fonds internes, Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2022-04-01 au 2028-03-31
  • Altered retinal response as a neurobiological component of the risk trajectory and of the developmental pathophysiology of major psychiatric disorders - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2022-04-01 au 2027-03-31
  • Identification des patrons alimentaires liés à l’incidence du cancer de la prostate - Fonds de recherche du Québec - Santé - Projet subsidiaire - Nouveaux Centres et Instituts de recherche - Subventions régulières (pour fins de gestion au VRRCI), co-chercheur - 2024-05-30 au 2025-05-31
  • Exploring the role of rare genetic variations in the risk for schizophrenia and bipolar disorder in patients from multi-affected kindreds in the Quebec founder population - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-04-01 au 2025-03-31
  • Identifying nutrition and lifestyle mediators of genetic susceptibility to obesity: towards a precision lifestyle medicine approach to obesity prevention - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2024-09-30
  • Investigating the role of non-coding variations in epilepsy - Instituts de recherche en santé du Canada, Université du Québec à Chicoutimi - UQAC , co-chercheur - 2019-04-01 au 2024-03-31
  • Transforming major brain disorder prevention by integrating genetic and socio-economic predispositions - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, chercheur principal - 2020-03-31 au 2023-06-30
  • Déterminer la qualité de la polypharmacie chez les aînés : une approche basée sur l’intelligence artificielle - Conseil de recherches en sciences naturelles et génie Canada, Instituts de recherche en santé du Canada - Subvention de fonctionnement : Projets de recherche concertée sur la santé (avec le CRSNG), co-chercheur - 2020-04-01 au 2023-03-31
  • Integrating genome structure information and statistical analysis of co-segregation of rare genetic variants with disease in families - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2017-04-01 au 2022-03-31

Publications

  • Integration of Genetic Familial Dependence Structure in Latent Class Models, Chantal Merette, Alexandre Bureau, Aurelie Labbe, The International Journal of Biostatistics, 2009, 10.2202/1557-4679.1126
  • A New Strategy for Linkage Analysis under Epistasis Taking into Account Genetic Heterogeneity, Michel Maziade, Marc-André Roy, Yvon C. Chagnon, Alain Fournier, Jordie Croteau, Chantal Mérette, Alexandre Bureau, Hum Hered, 2009, 10.1159/000228921
  • Detection of Phenotype Modifier Genes Using Two-Locus Linkage Analysis in Complex Disorders Such as Major Psychosis, Michel Maziade, Marc-André Roy, Yvon C. Chagnon, Alain Fournier, Chantal Mérette, Jordie Croteau, Alexandre Bureau, Hum Hered, 2012, 10.1159/000341392
  • Polygenic risk scores distinguish patients from non‐affected adult relatives and from normal controls in schizophrenia and bipolar disorder multi‐affected kindreds, Alexandre Bureau, Michel Maziade, Thomas Paccalet, Chantal Mérette, Sébastien Boies, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2018, 10.1002/ajmg.b.32614
  • Impulsive-aggressive behaviours and completed suicide across the life cycle: a predisposition for younger age of suicide., Turecki G, Lesage A, Seguin M, Bureau A, Renaud J, McGirr A, 2008, 10.1017/S0033291707001419
  • Application of microarray outlier detection methodology to psychiatric research-1, Gustavo Turecki, Alexandre Bureau, Carl Ernst, 2011, 10.6084/M9.FIGSHARE.41151
  • A Genome-Wide Copy Number Variant Study of Suicidal Behavior, Gustavo Turecki, J. John Mann, Dan Rujescu, David Goldman, Colin Hodgkinson, Ina Giegling, Chantal Mérette, Fatemeh Haghighi, Maria A. Oquendo, Hanga Galfalvy, Jordie Croteau, Alexandre Bureau, Jeffrey A. Gross, PLoS ONE, 2015, 10.1371/journal.pone.0128369
  • Profiling brain expression of the spermidine/spermine N 1 -acetyltransferase 1 (SAT1) gene in suicide, Gustavo Turecki, Alexandre Bureau, Barbara Schneider, Laura M. Fiori, Lilian Canetti, Carla Himmelman, Adolfo Sequeira, Chantal Mérette, Dan Rujescu, Timothy A. Klempan, Am. J. Med. Genet., 2009, 10.1002/ajmg.b.30920
  • Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia, Alexandre Bureau, Steve Bilodeau, Arnaud Droit, Charles Joly-Beauparlant, Loïc Mangnier, Life Science Alliance, 2022, 10.26508/lsa.202101156
  • Differential RNA expression between schizophrenic patients and controls of the dystrobrevin binding protein 1 and neuregulin 1 genes in immortalized lymphocytes., Maziade M, Mérette C, Bureau A, Roy MA, Chagnon YC, 2008, 10.1016/j.schres.2007.12.471
  • An Assessment of Gene-by-Environment Interactions in Developmental Dyslexia-Related Phenotypes, Cecilia Marino, Michel Maziade, Silvana Beri, Roberto Giorda, Maria Rosaria Cellino, Jordie Croteau, Ermanno Quadrelli, Daniela Simone, Marco Battaglia, Alexandre Bureau, Sara Mascheretti, Genes, Brain and Behavior, 2012, 10.1111/j.1601-183x.2012.12000.x
  • Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification., Parboosingh JS, McLeod DR, Scott JN, Chudley AE, Davey K, Wirrell E, Fujiwara TM, Glass HC, Bureau A, Boycott KM, Flavelle S, 2005, 10.1086/444400
  • A genome-wide association study of suicidal behavior, J. John Mann, Gustavo Turecki, Alexandre Bureau, Dan Rujescu, Ina Giegling, Yung-yu Huang, Ainsley Burke, Maria A. Oquendo, David Goldman, Colin Hodgkinson, Fatemeh Haghighi, Hanga Galfalvy, Am. J. Med. Genet., 2015, 10.1002/ajmg.b.32330
  • Genome-wide Epigenetic Regulation by Early-Life Trauma, Gustavo Turecki, Michael J. Meaney, Moshe Szyf, Naguib Mechawar, Alexandre Bureau, Ian Mahar, Volodymyr Yerko, Luis Navaro, Gilles Maussion, Matt Suderman, Benoit Labonté, Arch Gen Psychiatry, 2012, 10.1001/archgenpsychiatry.2011.2287
  • Follow-up of a Major Psychosis Linkage Site in 13q13-q14 Reveals Significant Association in Both Case-Control and Family Samples, Michel Maziade, Chantal Mérette, Thomas Paccalet, Marc-André Roy, Alain Fournier, Jordie Croteau, Yvon C. Chagnon, Alexandre Bureau, Biological Psychiatry, 2013, 10.1016/j.biopsych.2013.03.004
  • UGT2B17 gene deletion associated with an increase in bone mineral density similar to the effect of hormone replacement in postmenopausal women., Rousseau F, Bureau A, Bussières J, Giroux S, 2012, 10.1007/s00198-011-1662-6
  • Replication of linkage with bipolar disorder on chromosome 16p in the eastern Quebec population, Michel Maziade, Yvon C. Chagnon, Valérie Jomphe, Denis Cliche, Claudia Émond, Alain Fournier, Alexandre Bureau, Marc-André Roy, Chantal Mérette, Am. J. Med. Genet., 2007, 10.1002/ajmg.b.30673
  • Inferring rare disease risk variants based on exact probabilities of sharing by multiple affected relatives., Ruczinski I, Beaty TH, Albacha-Hejazi H, Mangold E, Murray JC, Marazita ML, Bailey-Wilson JE, Parker MM, Younkin SG, Bureau A, 2014, 10.1093/bioinformatics/btu198
  • Symptom dimensions as alternative phenotypes to address genetic heterogeneity in schizophrenia and bipolar disorder, Chantal Merette, Michel Maziade, Yvon Chagnon, Marc-André Roy, Isabel Moreau, Alexandre Bureau, Aurélie Labbe, Eur J Hum Genet, 2012, 10.1038/ejhg.2012.67
  • Application of microarray outlier detection methodology to psychiatric research, Gustavo Turecki, Alexandre Bureau, Carl Ernst, BMC Psychiatry, 2008, 10.1186/1471-244x-8-29
  • Plasma polychlorinated biphenyl and organochlorine pesticide concentrations in dementia: The Canadian Study of Health and Aging, Danielle Laurin, Alexandre Bureau, Suzanne L. Tyas, Éric Dewailly, Joan Lindsay, René Verreault, Edeltraut Kröger, Pierre-Hugues Carmichael, Pierre Ayotte, Thierry Comlan Marc Medehouenou, Environment International, 2014, 10.1016/j.envint.2014.04.016
  • Extension of the generalized disequilibrium test to polytomous phenotypes and two-locus models, Michel Maziade, Marc-André Roy, Yvon C. Chagnon, Jordie Croteau, Alexandre Bureau, Front. Genet., 2014, 10.3389/fgene.2014.00258
  • Mapping complex traits using Random Forests, Paul Van Eerdewegh, Kathleen Falls, Brooke Hayward, Josée Dupuis, Alexandre Bureau, BMC Genet, 2003, 10.1186/1471-2156-4-s1-s64
  • Inferring disease risk genes from sequencing data in multiplex pedigrees through sharing of rare variants, Ingo Ruczinski, Terri H. Beaty, Joan E. Bailey‐Wilson, Mary L. Marazita, Jeffrey C. Murray, Alan F. Scott, Hasan Albacha‐Hejazi, Margaret M. Parker, Jacqueline B. Hetmanski, Margaret A. Taub, Ferdouse Begum, Alexandre Bureau, Genetic Epidemiology, 2019, 10.1002/gepi.22155
  • Latent class model with familial dependence to address heterogeneity in complex diseases: adapting the approach to family-based association studies, Aurélie Labbe, Chantal Mérette, Arafat Tayeb, Jordie Croteau, Alexandre Bureau, Genet. Epidemiol., 2011, 10.1002/gepi.20566
  • A multimodal attempt to follow-up linkage regions using RNA expression, SNPs and CpG methylation in schizophrenia and bipolar disorder kindreds, Alexandre Bureau, Marc-André Roy, Alain Fournier, Jordie Croteau, Thomas Paccalet, Michel Maziade, Yvon C. Chagnon, European Journal of Human Genetics, 2020, 10.1038/s41431-019-0526-y
  • An S-Plus Implementation of Hidden Markov Models in Continuous Time, Stephen C. Shiboski, James P. Hughes, Alexandre Bureau, Journal of Computational and Graphical Statistics, 2000, 10.1080/10618600.2000.10474903
  • Polychlorinated biphenyls and organochlorine pesticides in plasma of older Canadians, Danielle Laurin, Alexandre Bureau, Suzanne L. Tyas, Éric Dewailly, Joan Lindsay, René Verreault, Edeltraut Kröger, Pierre-Hugues Carmichael, Pierre Ayotte, Thierry Comlan Marc Medehouenou, Environmental Research, 2011, 10.1016/j.envres.2011.09.017
  • Estimating genetic effect sizes under joint disease-endophenotype models in presence of gene-environment interactions, Louis Pérusse, Claude Bouchard, Marie-Claude Vohl, Christian Couture, Jordie Croteau, Alexandre Bureau, Front. Genet., 2015, 10.3389/fgene.2015.00248
  • High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density, François Rousseau, David E.C. Cole, Alexandre Bureau, Johanne Bussières, Valérie Clément, Latifa Elfassihi, Sylvie Giroux, Bone, 2010, 10.1016/j.bone.2010.06.030
  • Whole exome sequencing of distant relatives in multiplex families implicates rare variants in candidate genes for oral clefts., Beaty TH, Scott AF, Ling H, Doheny KF, Wu-Chou YH, Field LL, Alqosayer K, Albacha-Hejazi H, Szymczak S, Li Q, Cropp CD, Bailey-Wilson JE, Hetmanski JB, Ludwig KU, Noethen MM, Mangold E, Murray JC, Taub MA, Marazita ML, Ruczinski I, Parker MM, Bureau A, 2014, 10.1534/genetics.114.165225
  • Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study., Turecki G, Tremblay RE, Carbonneau R, Hébert M, Vitaro F, Barker ED, Jomphe V, Mérette C, Bureau A, Brezo J, 2010, 10.1038/mp.2009.19
  • Identifying SNPs predictive of phenotype using random forests, Paul Van Eerdewegh, Tim P. Keith, Brooke Hayward, Kathryn L. Lunetta, Kathleen Falls, Jos�e Dupuis, Alexandre Bureau, Genet. Epidemiol., 2005, 10.1002/gepi.20041
  • Using disease symptoms to improve detection of linkage under genetic heterogeneity., Mérette C, Croteau J, Labbe A, Bureau A, 2008, 10.1002/gepi.20320
  • Association of Polyaminergic Loci With Anxiety, Mood Disorders, and Attempted Suicide, Gustavo Turecki, Alexandre Bureau, Richard E. Tremblay, Frank Vitaro, Jordie Croteau, Valérie Jomphe, Brigitte Wanner, Laura M. Fiori, PLoS ONE, 2010, 10.1371/journal.pone.0015146
  • Inferring Disease Risk Genes from Sequencing Data in Multiplex Pedigrees Through Sharing of Rare Variants, Ingo Ruczinski, Terri H. Beaty, Joan E. Bailey-Wilson, Mary L. Marazita, Jeffrey C. Murray, Alan F. Scott, Hasan Albacha-Hejazi, Margaret M. Parker, Jacqueline Hetmanski, Margaret A. Taub, Ferdouse Begum, Alexandre Bureau, 2018, 10.1101/285874
  • Considerations for the development of a reference method for sequencing of haploid DNA – an opinion paper on behalf of the IFCC Committee on Molecular Diagnostics. International Federation of Clinical Chemistry and Laboratory Medicine, Ian Young, Mario Pazzagli, Deborah Payne, Ron van Schaik, Cyril Mamotte, Alexandre Bureau, Michael Neumaier, Heinz Schimmel, David Gancberg, François Rousseau, Clinical Chemistry and Laboratory Medicine, 2009, 10.1515/cclm.2009.319
  • Heterogeneity in the longitudinal courses of global functioning in children at familial risk of major psychiatric disorders: Association with trauma and familial characteristics, Michel Maziade, Marie‐Claude Boisvert, Énora Fortin‐Fabbro, Abdoulaye Dioni, Valérie Jomphe, Camille Lafrance, Jasmin Ricard, Nicolas Berthelot, Alexandre Bureau, Bipolar Disorders, 2024, 10.1111/bdi.13386
  • Global gene expression profiling of the polyamine system in suicide completers, Gustavo Turecki, Chantal Mérette, Simon Noël, Jordie Croteau, Aurélie Labbe, Alexandre Bureau, Laura M. Fiori, Int. J. Neuropsychopharm., 2011, 10.1017/s1461145710001574
  • Solving genetic heterogeneity in extended families by identifying sub-types of complex diseases, Chantal Mérette, Alexandre Bureau, Aurélie Labbe, Arafat Tayeb, Comput Stat, 2011, 10.1007/s00180-010-0224-2
  • Statistics to prioritize rare variants in family‐based sequencing studies with disease subtypes, Jinko Graham, Alexandre Bureau, Angela Brooks‐Wilson, Fabiha Binte Farooq, Christina Nieuwoudt, Genetic Epidemiology, 2024, 10.1002/gepi.22579
  • Evidence for a novel glaucoma locus at chromosome 3p21-22, Alexandre Bureau, Terence P. Speed, Jamie Craig, David A. Mackey, Simon J. Foote, Paul N. Baird, Hum Genet, 2005, 10.1007/s00439-005-1296-x
  • Applications of continuous time hidden Markov models to the study of misclassified disease outcomes, James P. Hughes, Stephen Shiboski, Alexandre Bureau, Statist. Med., 2003, 10.1002/sim.1270
  • Multivariate extension of penalized regression on summary statistics to construct polygenic risk scores for correlated traits, Alexandre Bureau, Maripier Isabelle, Michel Maziade, Simon L. Girard, Jasmin Ricard, Meriem Bahda, Human Genetics and Genomics Advances, 2023, 10.1016/j.xhgg.2023.100209
  • An assessment of gene-by-environment interactions in developmental dyslexia-related phenotypes, C. Marino, M. Maziade, S. Beri, R. Giorda, M. R. Cellino, J. Croteau, E. Quadrelli, D. Simone, M. Battaglia, A. Bureau, S. Mascheretti, Genes, Brain and Behavior, 2012, 10.1111/gbb.12000
  • Pedigree selection and tests of linkage in a Hutterite asthma pedigree., Morgan K, Goldstein DR, Fujiwara TM, Brewer CG, Crumley MJ, Roslin NM, Loredo-Osti JC, Bureau A, Greenwood CM, 2001
  • Chromosome 13q13–q14 locus overlaps mood and psychotic disorders: the relevance for redefining phenotype, Chantal Mérette, Alain Fournier, Alexandre Bureau, Marc-André Roy, Yvon C Chagnon, Michel Maziade, Eur J Hum Genet, 2009, 10.1038/ejhg.2008.268
  • Association With Replication Between Estrogen-Related Receptor Gamma ( ESRRG ) Polymorphisms and Bone Phenotypes in Women of European Ancestry, François Rousseau, David EC Cole, Nathalie Laflamme, Alexandre Bureau, Sylvie Giroux, Latifa Elfassihi, Journal of Bone and Mineral Research, 2009, 10.1359/jbmr.091014
  • Estimating Interaction Between Genetic and Environmental Risk Factors, L Adrienne Cupples, Jose M. Ordovas, Mamadou S. Diallo, Alexandre Bureau, Epidemiology, 2008, 10.1097/ede.0b013e31815c4d0e

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Ariane tako Ange - Doctorat - En cours
  • Alexis Jobin - Maîtrise avec mémoire - En cours
  • Samir Oubninte - Doctorat - En cours
  • Abdoulaye Dioni - Doctorat - En cours
  • Fousseni Sama - Maîtrise avec mémoire - En cours
  • N'Vyssan Samuella Bonou - Maîtrise avec mémoire - 2017/05
  • Rossana Peredo Nunez De Arco - Maîtrise avec mémoire - 2017/09
  • Sara Carazo Perez - Doctorat - 2018/05
  • Joseline Zafack Guetsop - Doctorat - 2019/09
  • Chaymae Yousfi - Maîtrise avec mémoire - 2020/09
  • Meriem Bahda - Maîtrise avec mémoire - 2022/01
  • Loïc Mangnier - Doctorat - 2022/09
  • Candide Ahouehome - Maîtrise avec mémoire - 2024/05

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Épidémiologie
  • Biostatistique

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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