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Christophe Proulx
Professeur agrégé
Directeur(trice), Centre thématique de recherche en neurosciences
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de médecine :
Neurosciences et santé mentale
Domaines et intérêts de recherche du (de la) professeur(e) :
Neurosciences, santé mentale et toxicomanies
- Dépression
- Motivations et émotions
- Stress
Projets de recherche
- Les mécanismes neuronaux impliqués dans les réponses comportementales reliées aux émotions dans les conditions normales et pathologiques - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2022-07-01 au 2026-06-30
- Functional dissection of the serotoninergic system in normal and pathological conditions - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
- Plateforme électro-optique intelligente pour le contrôle neuronal en boucle fermée chez les animaux en mouvement libre - Fonds de recherche du Québec - Nature et technologies - Projet de recherche en équipe, co-chercheur - 2020-04-01 au 2023-03-31
- The neural mechanisms involved in behavioral responses related to emotions - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2017-04-01 au 2022-03-31
Publications
- A novel role for the lateral habenula in fear learning, Piriz, J., Mendez, P., Medina, J.H., Pafundo, D.E., Proulx, C.D., Ihidoype, M.R., Sachella, T.E., Neuropsychopharmacology, 2022, 10.1038/s41386-022-01294-5
- Locking away depression, Jose Cesar Hernandez Silva, Christophe Proulx, Science, 2024, 10.1126/science.adq9566
- Photolabelling the urotensin II receptor reveals distinct agonist- and partial-agonist-binding sites, Leduc, R., Escher, E., Lavigne, P., Proulx, C.D., Beaulieu, M.-E., Holleran, B.J., Biochemical Journal, 2007, 10.1042/BJ20060943
- Reward processing by the lateral habenula in normal and depressive behaviors, Malinow, R., Hikosaka, O., Proulx, C.D., Nature Neuroscience, 2014, 10.1038/nn.3779
- A Wireless Optoelectronic Neuroscience Platform for Chronic Fluorescence Sensing in Freely Behaving Rodents, Gosselin, B., De Koninck, Y., Proulx, C.D., Martel, C.B.S., Martianova, E., Gagnon-Turcotte, G., Khiarak, M.N., Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2018, 10.1109/EMBC.2018.8512653
- Mutational analysis of the conserved Asp2.50 and ERY motif reveals signaling bias of the urotensin II receptor, Leduc, R., Guillemette, G., Escher, E., Boucard, A.A., Holleran, B.J., Proulx, C.D., Molecular Pharmacology, 2008, 10.1124/mol.108.045054
- Independence of Cued and Contextual Components of Fear Conditioning is Gated by the Lateral Habenula, Joaquin Piriz, Pablo Mendez, Jorge H. Medina, Diego E. Pafundo, Christophe D. Proulx, Marina R. Ihidoype, Tomas E. Sachella, 2020, 10.1101/2020.07.12.197319
- Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice, Welsh, D.K., Malinow, R., Barandas, R., Proulx, C.D., Long, J.E., Landgraf, D., Biological Psychiatry, 2016, 10.1016/j.biopsych.2016.03.1050
- Involvement of a cytoplasmic-tail serine cluster in urotensin II receptor internalization, Leduc, R., Guillemette, G., Laporte, S.A., Escher, E., Simaan, M., Proulx, C.D., Biochemical Journal, 2005, 10.1042/BJ20040807
- A Wireless Fiber Photometry System Based on a High-Precision CMOS Biosensor with Embedded Continuous-Time Σ Δ Modulation, Gosselin, B., De Koninck, Y., Martel, S., Proulx, C.D., Bories, C., Martianova, E., Khiarak, M.N., IEEE Transactions on Biomedical Circuits and Systems, 2018, 10.1109/TBCAS.2018.2817200
- A neural pathway controlling motivation to exert effort, Malinow, R., Shabel, S.J., Monk, B., Loi, A., Molina, C., Milivojevic, D., Aronson, S., Proulx, C.D., Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1801837115
- NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis, Dutchak, P.A., Sephton, C.F., Proulx, C.D., Chahine, M., Plumereau, Q., Venkatasubramani, J.P., Sévigny, M., Pelaez, M.C., Silva, J.C.H., Hui, J.B., eNeuro, 2022, 10.1523/ENEURO.0317-21.2022
- Multi-fiber photometry to record neural activity in freely-moving animals, Proulx, C.D., Aronson, S., Martianova, E., Journal of Visualized Experiments, 2019, 10.3791/60278
- Coherent activity at three major lateral hypothalamic neural outputs controls the onset of motivated behavior responses, Christophe D. Proulx, Danahe Leblanc, Tommy Doucet Gentiletti, Nikola Pausic, Alicia Pageau, Ekaterina Martianova, 2021, 10.1101/2021.04.28.441785
- Input to the Lateral Habenula from the Basal Ganglia Is Excitatory, Aversive, and Suppressed by Serotonin, Malinow, R., Murphy, R., Trias, A., Proulx, C., Shabel, S., Neuron, 2012, 10.1016/j.neuron.2012.02.037
- Hypothalamic neuronal outputs transmit sensorimotor signals at the onset of locomotor initiation, Christophe D. Proulx, Benoît Labonté, Arturo Marroquin Rivera, Danahé Leblanc, Tommy Doucet Gentiletti, Nikola Pausic, Alicia Pageau, Renata Sadretdinova, Ekaterina Martianova, iScience, 2023, 10.1016/j.isci.2023.108328
- Synaptic potentiation onto habenula neurons in the learned helplessness model of depression, Malinow, R., Henn, F., Schulz, D., Proulx, C.D., Chung, C., Mirrione, M., Piriz, J., Li, B., Nature, 2011, 10.1038/nature09742
- Chronic Stress Induces Sex-Specific Functional and Morphological Alterations in Corticoaccumbal and Corticotegmental Pathways, Labonté, B., Proulx, C.D., Sephton, C.F., Timofeev, I., Seigneur, J., Cherasse, Y., Arsenault, E., Blanchette, L.-J., Morency, D., Lavigne, A.-A., Quessy, F., Hernandez Silva, J.C., Pelaez, M.C., Bittar, T.P., Biological Psychiatry, 2021, 10.1016/j.biopsych.2021.02.014
- Electro-Optic Fiber Photometry Front-End for Live Wireless Brain Calcium Sensing Applications, Benoit Gosselin, Christophe D. Proulx, Karen Bakhshetyan, Jean-Luc Néron, Marina R. Ihidoype, Etienne Ransford, IEEE Sensors Journal, 2023, 10.1109/JSEN.2023.3326740
- Optogenetic inhibition of synaptic release with chromophore-assisted light inactivation (CALI), Tsien, R., Jin, Y., Malinow, R., Proulx, C., Nabavi, S., Zhou, K., Sann, S., Lin, J., Neuron, 2013, 10.1016/j.neuron.2013.05.022
- Engineering a memory with LTD and LTP, Malinow, R., Tsien, R.Y., Lin, J.Y., Proulx, C.D., Fox, R., Nabavi, S., Nature, 2014, 10.1038/nature13294
- GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment, Malinow, R., Piriz, J., Proulx, C.D., Shabel, S.J., Science, 2014, 10.1126/science.1250469
- Chronic Social Defeat Stress Induces Pathway-Specific Adaptations at Lateral Habenula Neuronal Outputs, Christophe D. Proulx, Benoît Labonté, Arturo Marroquin Rivera, Nikola Pausic, Jose Cesar Hernandez Silva, The Journal of Neuroscience, 2024, 10.1523/JNEUROSCI.2082-23.2024
- Ascorbic acid decreases the binding affinity of the AT1 receptor for angiotensin II, Guillemette, G., Leduc, R., Escher, E., Gobeil Jr., F., Bélanger, S., Arguin, G., Proulx, C.D., Leclerc, P.C., American Journal of Hypertension, 2008, 10.1038/ajh.2007.1
- Biological properties and functional determinants of the urotensin II receptor, Leduc, R., Guillemette, G., Escher, E., Lavigne, P., Holleran, B.J., Proulx, C.D., Peptides, 2008, 10.1016/j.peptides.2007.10.027
Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Renata Sadretdinova - Doctorat - En cours
- Luca Pancotti - Doctorat - En cours
- Duncan Noble - Doctorat - En cours
- Marina Ihidoype - Doctorat - En cours
- Lydia Saïdi - Doctorat - En cours
- Maya Chebl - Maîtrise avec mémoire - 2019/01
- Ekaterina Martianova - Doctorat - 2020/09
- Étienne Ransford - Maîtrise avec mémoire - 2023/05
- Jose Cesar Hernandez Silva - Doctorat - 2024/05
Encadrement d'étudiant(e)s
Direction de recherche dans les domaines suivants :
- Biologie cellulaire et moléculaire
- Neurobiologie — Neurosciences
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