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Emmanuel Planel

Professeur titulaire

Emmanuel Planel
Emmanuel.Planel@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Neurosciences, santé mentale et toxicomanies
  • Maladie d'Alzheimer
  • Maladies neurodégénératives
  • Démences
Vieillissement
  • Nutrition et vieillissement
  • Âge et facteurs de risques

Projets de recherche

  • Physiological regulation of tau protein - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2023-04-01 au 2028-03-31
  • Microglial tau: a missing link between neuroinflammation and neurodegeneration in TDP-43 proteinopathies - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-04-01 au 2028-03-31
  • Microglial tau: a missing link between neuroinflammation and neurodegeneration in TDP-43 proteinopathies - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-03-01 au 2028-03-31
  • Mechanisms of neuronal and vascular impairments in ischemic retinopathies - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-04-01 au 2024-03-31
  • Untangling tau contribution to cognitive impairments in Huntington’s disease. - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-04-01 au 2024-03-31

Publications

  • Repurposing beta3-adrenergic receptor agonists for Alzheimer’s disease: Beneficial effects on recognition memory and amyloid pathology in a mouse model, Calon F, Pifferi F, Planel E, Mélançon K, Tremblay C, Hozer C, Vu T, Vrabic N, Tournissac M, 2020, 10.1101/2020.05.25.114454
  • Passive immunization against phosphorylated tau improves features of Huntington's disease pathology., Francesca Cicchetti, Planel E, Davies P, Saint-Pierre M, Denis HL, Eva LEPINAY, Aurelie de Rus Jacquet, Masnata M, Melanie Alpaugh, Molecular therapy : the journal of the American Society of Gene Therapy, 2022, 10.1016/j.ymthe.2022.01.020
  • Old age potentiates cold-induced tau phosphorylation: linking thermoregulatory deficit with Alzheimer's disease., Calon F, Planel E, François A, Tournissac M, Vandal M, Neurobiology of aging, 2016, 10.1016/j.neurobiolaging.2016.09.024
  • Postoperative cognitive decline: where art tau?, Planel E, Eckenhoff RG, Anesthesiology, 2012, 10.1097/aln.0b013e31824be8e1
  • U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy., Takashima A, Nakayama KI, Takahashi R, Planel E, Chui DH, Murayama M, Kamura T, Matsumoto M, Hatakeyama S, Journal of neurochemistry, 2004, 10.1111/j.1471-4159.2004.02713.x
  • Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease., Calon F, Marette A, Planel E, Traversy MT, Bousquet M, Drouin-Ouellet J, St-Amour I, Tremblay C, Tournissac M, White PJ, Vandal M, Neurobiology of aging, 2016, 10.1016/j.neurobiolaging.2016.03.024
  • Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation., Small SA, Arancio O, Duff K, Ganetzky B, Honig LS, Kreber R, Ho L, Herman M, Planel E, Staniszewski A, Yu R, Zhang H, Flores I, Muhammad A, Proceedings of the National Academy of Sciences of the United States of America, 2008, 10.1073/pnas.0802545105
  • microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice., Hébert SS, Cicchetti F, Calon F, Droit A, Planel E, Vallée M, Saint-Pierre M, Smith PY, Dorval V, Goupil C, Rainone S, Hernandez-Rapp J, Scientific reports, 2016, 10.1038/srep30953
  • Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing., Duff K, Lahiri DK, Lau LF, Planel E, Liu L, Krishnamurthy P, Herman M, Figueroa H, Wang L, Maurin T, Marié I, Ma J, Bailey J, Maloney B, Yu WH, Wen Y, Neuron, 2008, 10.1016/j.neuron.2008.02.024
  • Biochemical isolation of insoluble tau in transgenic mouse models of tauopathies., Planel E, Bretteville A, Julien C, Methods in molecular biology (Clifton, N.J.), 2012, 10.1007/978-1-61779-551-0_32
  • Untangling memory deficits., Planel E, Duff K, Nature medicine, 2005, 10.1038/nm0805-826
  • Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)., Planel E, Calon F, Julien C, Theriault P, Lalonde R, Filali M, Behavioural brain research, 2012, 10.1016/j.bbr.2012.07.004
  • Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells., Takashima A, Ishiguro K, Yoshioka K, Hashikawa T, Sun X, Tanemura K, Planel E, Miyasaka T, Murayama M, Chui DH, Akagi T, Sato S, Tatebayashi Y, The Journal of biological chemistry, 2002, 10.1074/jbc.m202241200
  • Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease., Planel E, Calon F, Marette A, Whittington RA, Morin F, Marcouiller F, Julien C, Turgeon A, El Khoury NB, Gratuze M, Neurobiology of disease, 2016, 10.1016/j.nbd.2016.10.004
  • Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease., Planel E, Whittington RA, Bissonnette S, Poitras I, Bezeau F, Goupil C, Dickler M, Morin F, Milot-Rousseau P, Cisbani G, Julien C, Noël A, Gratuze M, Human molecular genetics, 2014, 10.1093/hmg/ddu456
  • In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice., Mathews PM, Planel E, Matsuoka Y, Levy E, Choi JH, Diaz NS, Berger JD, Mazzella MJ, Morales-Corraliza J, PloS one, 2009, 10.1371/journal.pone.0007134
  • Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar., Hemmings HC, Planel E, Orser BA, Ma D, Loepke AW, Herold KF, Giffard RG, Fiskum G, Culley DJ, Crosby G, Brambrink A, Blomgren K, Absalom AR, Jevtovic-Todorovic V, British journal of anaesthesia, 2013, 10.1093/bja/aet177
  • Starvation and inhibition of lysosomal function increased tau secretion by primary cortical neurons., Leclerc N, Planel E, Rémillard-Labrosse G, Plouffe V, Mohamed NV, Scientific reports, 2014, 10.1038/srep05715
  • Alzheimer's disease and anesthesia., Planel E, El-Khoury NB, Whittington RA, Papon MA, Frontiers in neuroscience, 2011, 10.3389/fnins.2010.00272
  • Anesthesia and tau pathology., Planel E, Dickler MF, Bretteville A, Whittington RA, Progress in neuro-psychopharmacology & biological psychiatry, 2013, 10.1016/j.pnpbp.2013.03.004
  • Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease., Takashima A, Tatebayashi Y, Ishiguro K, Murayama O, Sato S, Tanemura K, Chui DH, Launey T, Miyasaka T, Planel E, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 10.1523/jneurosci.5561-03.2004
  • Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation., Planel E, Charron J, Morin F, El-Khoury NB, Petry FR, Julien C, Marcouiller F, Maurin TO, Emala CW, Virág L, Bretteville A, Whittington RA, Scientific reports, 2013, 10.1038/srep01388
  • Tau aggregates: toxic, inert, or protective species?, Planel E, Bretteville A, Journal of Alzheimer's disease : JAD, 2008, 10.3233/jad-2008-14411
  • Advances and Challenges in Understanding MicroRNA Function in Tauopathies: A Case Study of miR-132/212., Hébert SS, Planel E, St-Amour I, Turgeon A, Goupil C, Loiselle A, Rainone S, Keraudren R, Petry S, Hernandez-Rapp J, Boscher E, Frontiers in neurology, 2020, 10.3389/fneur.2020.578720
  • High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology., Planel E, Marette A, Hébert SS, Calon F, Morin F, Julien J, Gratuze M, Neurobiology of aging, 2016, 10.1016/j.neurobiolaging.2016.07.016
  • Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing., Duff KE, Yu WH, Lau LF, Liu L, Wang L, Figueroa HY, Herman M, Planel E, Wen Y, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 10.1523/jneurosci.5245-07.2008
  • A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease., Aisen PS, Gozes I, Arancio O, Planel E, Walker BR, Lecanu L, Feng L, Li HF, Hirata-Fukae C, Ma L, Gray AJ, Jouroukhin Y, Matsuoka Y, The Journal of pharmacology and experimental therapeutics, 2008, 10.1124/jpet.107.130526
  • Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice., Planel E, Hébert SS, Mathews PM, Amrani A, Gaudreau S, Petry FR, Bretteville A, Morin F, Julien C, Marcouiller F, El Khoury NB, Papon MA, Diabetes, 2012, 10.2337/db12-0187
  • Differential Regulation of Tau Exon 2 and 10 Isoforms in Huntington's Disease Brain., St-Amour I, Hébert SS, Planel E, Sergeant N, Keraudren R, Nateghi B, Petry S, Neuroscience, 2022, 10.1016/j.neuroscience.2022.07.014
  • Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature., Planel E, Mongrain V, Hébert SS, Whittington RA, Keraudren R, Morin F, Petry S, Gratuze M, Guisle I, Sleep, 2020, 10.1093/sleep/zsz266
  • Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer's disease., Fujita SC, Ishiguro K, Planel E, Yanagisawa M, FEBS letters, 1999, 10.1016/s0014-5793(99)01480-5
  • Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia., Duff KE, Lau LF, Nelson RB, Schachter JB, Wang L, Herman M, Krishnamurthy P, Wen Y, Liu L, Finley JE, Nolan CE, Richter KE, Planel E, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/jneurosci.4854-06.2007
  • Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer's disease-like tau pathology., Planel E, Morin F, Petry FR, Julien J, Gratuze M, Scientific reports, 2017, 10.1038/srep46359
  • Memory formation and retention are affected in adult miR-132/212 knockout mice., Hébert SS, Goodman RH, Magill ST, Planel E, Goupil C, Filali M, Smith PY, Hernandez-Rapp J, Behavioural brain research, 2015, 10.1016/j.bbr.2015.03.032
  • MicroRNA-138 Overexpression Alters Aβ42 Levels and Behavior in Wildtype Mice., Hébert SS, Planel E, Loiselle A, Keraudren R, Petry S, Goupil C, Boscher E, Frontiers in neuroscience, 2020, 10.3389/fnins.2020.591138
  • Insulin resistance and obesity: how do they affect tau pathology?, Planel E, Morin F, Marcouiller F, Julien C, Papon M, DicklerI M, El Khoury N, Gratuze M, Molecular neurodegeneration, 2013, 10.1186/1750-1326-8-s1-p67
  • Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease., Cicchetti F, Freeman TB, Planel E, Kordower JH, Maxan A, Cisbani G, Brain : a journal of neurology, 2017, 10.1093/brain/awx255
  • Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions., Planel E, Whittington RA, Hébert SS, Calon F, Morin F, Bretteville A, Pelletier J, Petry FR, PloS one, 2014, 10.1371/journal.pone.0094251
  • Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors., Planel E, Hébert SS, Lévesque G, Mouginot D, Poitras I, Petry FR, El Khoury NB, Julien C, Marcouiller F, Bretteville A, Scientific reports, 2012, 10.1038/srep00480
  • Hypothermia and Alzheimer's disease neuropathogenic pathways., Planel E, Chouinard F, Papon MA, Whittington RA, Current Alzheimer research, 2010, 10.2174/156720510793611646
  • Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer's disease., Calon F, Marette A, Planel E, Tremblay C, St-Amour I, Chevrier G, White PJ, Vandal M, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, 10.1096/fj.14-268482
  • Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer's Disease., Desrumaux C, Devarajan PV, Laurent Givalois, Rajshree SL, Durand T, OGER Camille, Planel E, Morin F, Vitalis M, Geoffrey CANET, Acar N, Claire VIGOR, Otaegui L, Urgin T, John R, Zussy C, Antioxidants (Basel, Switzerland), 2022, 10.3390/antiox11050838
  • Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice., Planel E, Marette A, Hébert SS, Calon F, Nicholls SB, Morin F, Marcouiller F, Julien C, Papon MA, Petry F, Gratuze M, El Khoury NB, Neurobiology of disease, 2016, 10.1016/j.nbd.2016.01.005
  • Propofol directly increases tau phosphorylation., Planel E, Emala CW, Morin F, Julien C, El Khoury NB, Papon MA, Marcouiller F, Virág L, Whittington RA, PloS one, 2011, 10.1371/journal.pone.0016648
  • Insulin dysfunction and Tau pathology., Planel E, Bretteville A, Papon MA, Gratuze M, El Khoury NB, Frontiers in cellular neuroscience, 2014, 10.3389/fncel.2014.00022
  • Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model., Calon F, Pifferi F, Planel E, Mélançon K, Tremblay C, Hozer C, Vrabic N, Vu TM, Tournissac M, Alzheimer's research & therapy, 2021, 10.1186/s13195-021-00842-3
  • Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia., Planel E, Hébert SS, Frédéric Calon, Whittington RA, Kérauden R, Françoise Morin, Fereydouni-Forouzandeh P, Pétry S, Geoffrey CANET, Isabelle GUISLE, Neurobiology of aging, 2022, 10.1016/j.neurobiolaging.2022.02.011
  • ERK (MAPK) does not phosphorylate tau under physiological conditions in vivo or in vitro., Planel E, Charron J, Morin F, Petry FR, Julien J, Poitras I, Noël A, Neurobiology of aging, 2014, 10.1016/j.neurobiolaging.2014.11.005
  • Differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology fed with Western diet., Planel E, Marette A, Morin F, Julien J, Gratuze M, Progress in neuro-psychopharmacology & biological psychiatry, 2017, 10.1016/j.pnpbp.2017.08.001
  • Regulation of brain insulin signaling: A new function for tau., Planel E, Gratuze M, The Journal of experimental medicine, 2017, 10.1084/jem.20170979
  • miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo., Hébert SS, Fernandez-Gomez FJ, Bennett DA, Planel E, Morin F, Parsi S, Dorval V, Goupil C, Bisht K, Lecours C, Jolivette F, Hernandez-Rapp J, Smith PY, Human molecular genetics, 2015, 10.1093/hmg/ddv377
  • Impaired Resolution of Inflammation in Alzheimer's Disease: A Review., Terrando N, Planel E, Whittington RA, Frontiers in immunology, 2017, 10.3389/fimmu.2017.01464
  • Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia., Duff KE, Whittington RA, Dickson DW, Yu WH, Du AL, Virag L, Liu L, Bretteville A, Planel E, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009, 10.1096/fj.08-122424
  • Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro., Planel E, Morin F, Bretteville A, Wong K, El Khoury N, Papon MA, Marcouiller F, Truchetti G, Poitras I, Noël A, Petry FR, Gratuze M, Virág L, Whittington RA, Neurobiology of aging, 2015, 10.1016/j.neurobiolaging.2015.05.002
  • Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation., Planel E, Hébert SS, Baillargeon J, El Khoury NB, Bretteville A, Marcouiller F, Julien C, PloS one, 2012, 10.1371/journal.pone.0040020
  • Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma., Burns MP, Planel E, Villapol S, Zapple DN, Alikhani AD, Wilkins TE, Chellappa D, Barton DJ, Parsadanian M, Neustadtl A, Noël A, Winston CN, The American journal of pathology, 2016, 10.1016/j.ajpath.2015.11.006
  • Corrigendum: Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons., Pernet V, Planel E, Boudreau-Laprise M, Joly S, Mdzomba JB, Rodriguez L, Frontiers in molecular neuroscience, 2018, 10.3389/fnmol.2018.00390
  • A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment., Duff K, Arancio O, Yu WH, Figueroa H, Herman M, Wang L, Krishnamurthy P, Bretteville A, Planel E, Wen Y, Orozco IJ, Liu L, Neurobiology of disease, 2008, 10.1016/j.nbd.2008.03.005
  • Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein., Duff KE, Clark LN, Cookson MR, Wang L, Planel E, Figueroa HY, Dorado B, Yu WH, The American journal of pathology, 2009, 10.2353/ajpath.2009.080928
  • Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease., Calon F, Marette A, Giguere Y, Planel E, Virgili J, Lefrançois D, Emond V, Chevrier G, St-Amour I, Tremblay C, White PJ, Vandal M, Diabetes, 2014, 10.2337/db14-0375
  • Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons., Pernet V, Planel E, Boudreau-Laprise M, Joly S, Mdzomba JB, Rodriguez L, Frontiers in molecular neuroscience, 2018, 10.3389/fnmol.2018.00293
  • Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation., Calon F, Planel E, Hébert SS, Vu TM, Martinez-Cano RD, Bourassa P, Tournissac M, Molecular metabolism, 2019, 10.1016/j.molmet.2019.01.008
  • Arterial Stiffness Due to Carotid Calcification Disrupts Cerebral Blood Flow Regulation and Leads to Cognitive Deficits., Girouard H, Ferland G, Planel E, Petry FR, Gratuze M, Youwakim J, Vallerand D, Iulita MF, Muhire G, Journal of the American Heart Association, 2019, 10.1161/jaha.118.011630
  • Is Huntington's disease a tauopathy?, Planel E, Cicchetti F, Cisbani G, Gratuze M, Brain : a journal of neurology, 2016, 10.1093/brain/aww021
  • MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy., Hébert SS, Buée L, Sergeant N, Planel E, Papon MA, Girard J, Delay C, Smith PY, Human molecular genetics, 2011, 10.1093/hmg/ddr330
  • Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo., Duff KE, Nixon RA, Takashima A, Davies P, Whittington RA, Yu WH, Figueroa HY, Bretteville A, Kumar A, Herman M, Liu L, Miyasaka T, Krishnamurthy P, Planel E, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 10.1523/jneurosci.4101-08.2008
  • Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo., Duff K, Bhat R, Wen Y, Krishnamurthy P, Burns M, Feinstein B, LaFrancois J, Wang L, Gaynor K, Suleman F, Meyerson J, Olm V, Zehr C, Planel E, Noble W, Proceedings of the National Academy of Sciences of the United States of America, 2005, 10.1073/pnas.0500466102
  • Gene network and pathway analysis of mice with conditional ablation of Dicer in post-mitotic neurons., Hébert SS, Buée L, Zommer N, Planel E, Calvo E, Delay C, Smith PY, Dorval V, PloS one, 2012, 10.1371/journal.pone.0044060
  • Co-occurrence of mixed proteinopathies in late-stage Huntington's disease., Hébert SS, Planel E, Goupil C, Turgeon A, St-Amour I, Acta neuropathologica, 2017, 10.1007/s00401-017-1786-7
  • Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease., First International Workshop on Anesthetics and Alzheimer's Disease, Planel E, Perouansky M, Palotás A, Jevtovic-Todorovic V, Hogan KJ, Eckenhoff RG, Eckenhoff MF, Culley DJ, Crosby GJ, Bickler PE, Baranov D, Anesthesia and analgesia, 2009, 10.1213/ane.0b013e318199dc72
  • Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways., Nicola Marchi, Laurent Givalois, Planel E, Desrumaux C, Audinat E, Moreno-Montano M, deBock F, Vitalis M, Garcia V, Blaquiere M, Hernandez C, Zussy C, Zub E, Geoffrey CANET, Epilepsia, 2022, 10.1111/epi.17186
  • Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse., Ishiguro K, Fujita SC, Yasutake K, Planel E, The Journal of biological chemistry, 2001, 10.1074/jbc.m102780200
  • The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice., Planel E, Bretzner F, Cicchetti F, Samadi P, Morin F, Bezeau F, Julien J, Poitras I, Truchetti G, Eyoum Jong L, Pflieger M, Petry FR, Josset N, Gratuze M, Brain research, 2019, 10.1016/j.brainres.2019.01.016
  • Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain., Planel E, Morin F, Poitras I, Petry F, Cheheltanan M, Lewkowitz-Shpuntoff H, Gratuze M, Virág L, Whittington RA, Neurobiology of aging, 2018, 10.1016/j.neurobiolaging.2018.10.027
  • Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration., De Strooper B, Buée L, Sergeant N, Silahtaroglu AN, Planel E, Galas MC, Smith P, Papadopoulou AS, Hébert SS, Human molecular genetics, 2010, 10.1093/hmg/ddq311
  • Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms., Takashima A, Duff KE, Wadzinski B, Luchsinger JA, Yu WH, Herman M, Wang L, Liu L, Miyasaka T, Tatebayashi Y, Planel E, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/jneurosci.3949-07.2007
  • Metabolic determinants of Alzheimer's disease: A focus on thermoregulation., Calon F, Planel E, Bosoi CR, Vandal M, Valentin-Escalera J, Leclerc M, Tournissac M, Ageing research reviews, 2021, 10.1016/j.arr.2021.101462
  • A Simple Method to Avoid Nonspecific Signal When Using Monoclonal Anti-Tau Antibodies in Western Blotting of Mouse Brain Proteins., Planel E, Hébert SS, Nicholls SB, Petry FR, Methods in molecular biology (Clifton, N.J.), 2017, 10.1007/978-1-4939-6598-4_15
  • Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau., Takashima A, Hashikawa T, Sato S, Planel E, Ishiguro K, Murayama M, Tanemura K, Fujiwara M, Iwasaki K, Mishima K, Akagi T, Chui DH, Miyasaka T, Tatebayashi Y, Proceedings of the National Academy of Sciences of the United States of America, 2002, 10.1073/pnas.202205599
  • Anesthesia, surgery and neurodegeneration. Preface., Planel E, Eckenhoff RG, Progress in neuro-psychopharmacology & biological psychiatry, 2013, 10.1016/j.pnpbp.2013.10.012
  • c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosis., Takashima A, Rivka R, Yoshioka K, Kikuchi N, Murayama M, Sahara N, Miyasaka T, Sato S, Chui DH, Planel E, Tatebayashi Y, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, 10.1096/fj.05-4362fje

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Sofía Diego Díaz - Doctorat - En cours
  • Kelly Godbout - Doctorat - En cours
  • Emma Rocaboy - Maîtrise avec mémoire - En cours
  • Geoffrey Canet - Post-doctorat - En cours
  • Aymane Lachhab - Maîtrise avec mémoire - En cours
  • François Marcouiller - Maîtrise avec mémoire - 2011/05
  • Noura El Khoury - Doctorat - 2013/05
  • Serena Petry - Doctorat - 2017/01
  • Maud Gratuze - Doctorat - 2017/05
  • Laura Eyoum Jong - Maîtrise avec mémoire - 2018/05
  • Andréanne Turgeon - Maîtrise avec mémoire - 2018/05
  • Ophélie Lerdu - Maîtrise avec mémoire - 2019/05
  • Isabelle Guisle - Doctorat - 2020/01
  • Julius Baya Mdzomba - Doctorat - 2021/01
  • Eva Lepinay - Maîtrise avec mémoire - 2023/01
  • Parissa Fereydouni-Forouzandeh - Maîtrise avec mémoire - 2023/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Médecine moléculaire
  • Neurobiologie — Neurosciences
  • Sciences cliniques et biomédicales

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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