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Fernando Forato Anhe

Professeur sous octroi adjoint

fernando.forato-anhe@criucpq.ulaval.ca
Centre de recherche de l'IUCPQ
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Santé cardiovasculaire, respiratoire et métabolisme

Domaines de recherche

  • Microbiome
    • Souris gnotobiotiques
  • Sciences cliniques sur le diabète
    • Modèles in vitro
  • Nutrition et métabolisme des humains
    • Fructose
  • Physiologie animale, endocrinologie
    • Chirurgie bariatrique
  • Physiologie animale, métabolisme
    • Inflammation métabolique
  • Physiologie animale, digestion
    • Barrière intestinale

Projets de recherche en cours

  • Unveiling the interplay between sugars, gut fungi, and enteroendocrine signals in shaping gut function - Conseil de recherches en sciences naturelles et génie Canada - Supplément Tremplin vers la découverte, chercheur principal - 2025-04-01 au 2030-03-31
  • Dissecting the role of the gut microbiota and the gut-liver axis in dysmetabolism induced by high fructose intake. - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2025-04-01 au 2030-03-31
  • Institut sur la nutrition et les aliments fonctionnels (INAF) - Université Concordia, Institut national de recherche scientifique (INRS), Université du Québec à Rimouski, Fonds de recherche du Québec - Nature et technologies, Université McGill, Université Laval - Fonds internes, Merinov - Centre d'innovation de l'aquaculture et des pêches du Québec - Regroupements stratégiques NT, co-chercheur - 2024-04-01 au 2030-03-31
  • Unveiling the interplay between sugars, gut microbes, and enteroendocrine signals in shaping gut function - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2025-04-01 au 2030-03-31
  • Harnessing Bacteroides to improve blood glucose - Diabète Canada - Subvention de fonctionnement : Mettre fin au diabète prix 2022, chercheur principal - 2023-12-01 au 2026-11-30
  • Étude de l'interaction microbe-hôte dans le contrôle du métabolisme de l'hôte - Subvention établissement de jeune chercheur - Fonds de recherche du Québec - Santé - Établissement de jeunes chercheurs - Juniors 1, chercheur principal - 2022-07-01 au 2026-06-30
  • Étude de l'interaction microbe-hôte dans le contrôle du métabolisme de l'hôte - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2022-07-01 au 2026-06-30
  • Programme de soutien aux nouveaux chercheurs - Université Laval - Fonds internes - Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, chercheur principal - 2022-07-01 au 2025-06-30
  • Détermination de l'impact des microbes et des nutriments sur la santé instestinale et l'homéostasie métamolique - Ministère de l'Économie et de l'Innovation et de l'énergie, Fondation Canadienne pour l'innovation (La) - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2024-06-01 au 2025-05-31

Financements des 2 dernières années

  • Effet de contrôle glycémique sur la progression de la stéatose hépatique au sein du REGISTRE-NASH du CHU de Québec-Université Laval - CHU de Québec – Université Laval – CHUL - Subvention en recherche clinique (PCRE), co-chercheur - 2024-01-23 au 2024-12-31
  • Institut sur la nutrition et les aliments fonctionnels (INAF) - Institut national de recherche scientifique (INRS), Fonds de recherche du Québec - Nature et technologies, Université Laval - Fonds internes, Université McGill, Université du Québec à Rimouski, Université de Sherbrooke - Regroupements stratégiques NT, co-chercheur - 2017-04-01 au 2024-03-31
  • Testing the efficacy of ultrafiltration processes to lower postbiotic charge in chemically defined liquid diets - Fonds de recherche du Québec - Nature et technologies - Projet subsidiaire d'un regroupement stratégique (pour fins de gestion au VRRCI), chercheur principal - 2022-12-19 au 2024-03-31

Publications

  • Determining the metabolic impact of postbiotics in mice., Schertzer JD, Bhatwa A, Anhê FF, STAR protocols, 2022, 10.1016/j.xpro.2021.101098
  • The type of fatty acid dictates their impact on gut permeability and nutrient absorption, Francemilson Goulart-Silva, Fernando Forato Anhe, Sayuri Miyamoto, Paula Bargi-Souza, Rodrigo Lucas de Faria, Rodrigo Pereira Prates, Paulo Henrique Evangelista-Silva, Physiology, 2024, 10.1152/physiol.2024.39.s1.304
  • Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice., Marette A, Roy D, Desjardins Y, Barbier O, Pilon G, Feutry P, Le Barz M, Dudonné S, Trottier J, Varin TV, Nachbar RT, Anhê FF, Gut, 2018, 10.1136/gutjnl-2017-315565
  • Dietary sugar lowers immunity and microbiota that protect against metabolic disease. , Fernando Forato Anhê, Cell metabolism, 2022, 10.1016/j.cmet.2022.09.006
  • Investigating the role of the gut in fructose induced glucose intolerance, Paulo H. Evangelista-Silva, Francielton Da Silva Lima, Caio Teixeira, Gabriel Anhe, Fernando Forato-Anhe, Eya Sellami, Physiology, 2024, 10.1152/physiol.2024.39.s1.2308
  • High fructose rewires gut glucose sensing via glucagon-like peptide 2 to impair metabolic regulation in mice, Fernando Forato Anhê, Patricia Mitchell, Khoudia Diop, Caio Jordão Teixeira, Paulo Henrique Evangelista-Silva, Eya Sellami, Molecular Metabolism, 2025, 10.1016/j.molmet.2025.102101
  • Micronutrients impact the gut microbiota and blood glucose., Schertzer JD, Chan DY, Singh AM, Cavallari JF, Anhê FF, Barra NG, The Journal of endocrinology, 2021, 10.1530/joe-21-0081
  • Quercetin decreases inflammatory response and increases insulin action in skeletal muscle of ob/ob mice and in L6 myotubes., Machado UF, Bordin S, Velloso LA, Hirabara SM, Lima GA, Anhê FF, Lellis-Santos C, Sollon C, Okamoto MM, Kinote A, Anhê GF, European journal of pharmacology, 2012, 10.1016/j.ejphar.2012.06.007
  • Metabolism Pharmacology, Andreas W. Herling, Fernando Forato Anhê, Olivier Barbier, Alexandre Caron, Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays, 2024, 10.1007/978-3-031-35529-5_66
  • Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota., Morrison KM, Desjardins EM, Yabut JM, Singh NP, Konyer NB, Hutchings EK, Syed SA, Szamosi JC, Oreskovich SM, Gunn E, Blondin DP, Barra NG, Ong FJ, Ahmed BA, Cell reports. Medicine, 2021, 10.1016/j.xcrm.2021.100397
  • A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice., Marette A, Levy E, Desjardins Y, Moine Q, Garofalo C, Varin TV, Matamoros S, Dudonné S, Pilon G, Roy D, Anhê FF, Gut, 2014, 10.1136/gutjnl-2014-307142
  • Postbiotics for NOD2 require nonhematopoietic RIPK2 to improve blood glucose and metabolic inflammation in mice., Schertzer JD, Ashkar AA, Anhê FF, Henriksbo BD, Duggan BM, Lee A, Foley KP, Barra NG, Cavallari JF, American journal of physiology. Endocrinology and metabolism, 2020, 10.1152/ajpendo.00033.2020
  • Postpartum glycemic homeostasis in early lactating rats is accompanied by transient and specific increase of soleus insulin response through IRS2/AKT pathway., Bordin S, Machado UF, Curi R, Carvalho CR, Marçal AC, Ribeiro LM, Anhê FF, Caperuto LC, Turrer TC, Hirabara SM, Anhê GF, American journal of physiology. Regulatory, integrative and comparative physiology, 2007, 10.1152/ajpregu.00902.2006
  • Life‐long exercise training and inherited aerobic endurance capacity produce converging gut microbiome signatures in rodents, Jonathan D. Schertzer, Mark A. Tarnopolsky, Steven L. Britton, Lauren G. Koch, Joshua P. Nederveen, Mats I. Nilsson, Kevin P. Foley, Nicole G. Barra, Soumaya Zlitni, Fernando F. Anhê, Physiological Reports, 2022, 10.14814/phy2.15215
  • Bacterial Postbiotics as Promising Tools to Mitigate Cardiometabolic Diseases, André Marette, Jonathan D. Schertzer, André Tchernof, Lais Rossi Perazza, Benjamin A. H. Jensen, Fernando F. Anhê, Journal of Lipid and Atherosclerosis, 2021, 10.12997/jla.2021.10.2.123
  • Arctic berry extracts target the gut-liver axis to alleviate metabolic endotoxaemia, insulin resistance and hepatic steatosis in diet-induced obese mice., Marette A, Roy D, Desjardins Y, Barbier O, Dewailly É, Lemire M, Lucas M, Harris CS, St-Pierre P, Trottier J, Dudonné S, Pilon G, Le Barz M, Varin TV, Anhê FF, Diabetologia, 2017, 10.1007/s00125-017-4520-z
  • Gut microbiota impairs insulin clearance in obese mice., Schertzer JD, Marette A, Schwab M, Plante R, Lau TC, Huang M, Chen CY, Henriksbo BD, Cavallari JF, Anhê FF, Barra NG, Duggan BM, Zlitni S, Foley KP, Molecular metabolism, 2020, 10.1016/j.molmet.2020.101067
  • Smad5 regulates Akt2 expression and insulin-induced glucose uptake in L6 myotubes., Bordin S, Anhê GF, Curi R, Boschero AC, Hirabara SM, Leite AR, Lellis-Santos C, Anhê FF, Molecular and cellular endocrinology, 2010, 10.1016/j.mce.2010.01.003
  • The Gut as a Potential Centerpiece in Fructose-Driven Dysmetabolism, Fernando Forato Anhê, Véronique Douard, Gabriel Forato Anhê, Eya Sellami, Current Molecular Biology Reports, 2023, 10.1007/s40610-023-00156-3
  • Camu-camu decreases hepatic steatosis and liver injury markers in overweight, hypertriglyceridemic individuals: A randomized crossover trial., Marette A, Vohl MC, Carreau AM, Anhê FF, Desjardins Y, Gagnon C, Larose É, Pilon G, Varin TV, Marois J, Gignac T, Daoust L, Morissette A, Agrinier AL, Cell reports. Medicine, 2024, 10.1016/j.xcrm.2024.101682
  • Comprehensive analysis of phenolic compounds and abscisic acid profiles of twelve native Canadian berries, Desjardins Y, Dewailly E, Harris C, Lemire M, Marette A, Pilon G, Anhê FF, Dubé P, Dudonné S, Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems, 2015, 10.1016/j.jfca.2015.09.003
  • Bacteria to alleviate metabolic syndrome., Marette A, Schertzer JD, Anhê FF, Nature medicine, 2019, 10.1038/s41591-019-0516-1
  • Intestinal permeability and peripheral immune cell composition are altered by pregnancy and adiposity at mid- and late-gestation in the mouse., Deborah Sloboda, Bowdish DME, Jonathan Schertzer , Anhê FF, Bellissimo CJ, Violet Patterson, Jazwiec PA, Kennelly BKE, Yeo E, Katherine M. Kennedy, Breznik JA, Tatiane Aparecida Ribeiro, PloS one, 2023, 10.1371/journal.pone.0284972
  • Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts., Marette A, Roy D, Levy E, Desjardins Y, Le Barz M, Varin TV, Anhê FF, Current obesity reports, 2015, 10.1007/s13679-015-0172-9
  • Host-Microbe Interplay in the Cardiometabolic Benefits of Dietary Polyphenols., Marette A, Schertzer JD, Dyck JRB, Choi BSY, Anhê FF, Trends in endocrinology and metabolism: TEM, 2019, 10.1016/j.tem.2019.04.002
  • Glucose alters the symbiotic relationships between gut microbiota and host physiology., Schertzer JD, Barra NG, Anhê FF, American journal of physiology. Endocrinology and metabolism, 2019, 10.1152/ajpendo.00485.2019
  • Type 2 diabetes influences bacterial tissue compartmentalisation in human obesity., Marette A, Tchernof A, Schertzer JD, Lelouvier B, Biertho L, Surette M, Marceau S, Richard D, Van Blerk S, Servant F, Varin TV, Jensen BAH, Anhê FF, Nature metabolism, 2020, 10.1038/s42255-020-0178-9
  • A microbial protein that alleviates metabolic syndrome., Marette A, Anhê FF, Nature medicine, 2017, 10.1038/nm.4261
  • Microbial-derived D-lactate Participates in Host Blood Glucose Metabolism, DANA KUKJE ZADA, FERNANDO ANHE, JONATHAN SCHERTZER, HAN FANG, Canadian Journal of Diabetes, 2024, 10.1016/j.jcjd.2024.09.093
  • Targeting macrophage scavenger receptor 1 promotes insulin resistance in obese male mice., Schertzer JD, Bowdish DME, Chan RW, Denou E, Foley KP, Anhê FF, Cavallari JF, Physiological reports, 2018, 10.14814/phy2.13930
  • Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice., Schertzer JD, Sloboda DM, Miller MS, Surette MG, Stacey HD, Wallace JG, Paniccia G, Anhê FF, Barra NG, Tamrakar AK, Duggan BM, Molecular metabolism, 2021, 10.1016/j.molmet.2021.101404
  • Human gut microbiota after bariatric surgery alters intestinal morphology and glucose absorption in mice independently of obesity., Fernando Forato Anhê, Gut, 2022, 10.1136/gutjnl-2022-328185
  • Metabolic endotoxemia is dictated by the type of lipopolysaccharide, Schertzer JD, Henriksbo BD, Cavallari JF, Barra NG, Anhê FF, 2021, 10.1101/2021.07.13.452270
  • Probiotics as Complementary Treatment for Metabolic Disorders., Marette A, Urdaci MC, Roy D, Levy E, Desjardins Y, Varin TV, Anhê FF, Le Barz M, Diabetes & metabolism journal, 2015, 10.4093/dmj.2015.39.4.291
  • Immunometabolism Sentinels: Gut Surface T-Cells Regulate GLP-1 Availability., Schertzer JD, Anhê FF, Barra NG, Endocrinology, 2019, 10.1210/en.2019-00215
  • Consistent gut bacterial and short-chain fatty acid signatures in hypoabsorptive bariatric surgeries correlate with metabolic benefits in rats., Richard D, Marette A, St-Pierre DH, Anhê FF, Varin TV, Tchernof A, Plamondon J, Roy MC, Lebel S, Biertho L, Lemoine N, Mukorako P, International journal of obesity (2005), 2021, 10.1038/s41366-021-00973-5
  • A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss., Marette A, Levy E, Roy D, Desjardins Y, Lecours MA, Fournier M, Pilon G, Dudonné S, Vilela V, Varin TV, Nachbar RT, Anhê FF, Molecular metabolism, 2017, 10.1016/j.molmet.2017.10.003
  • Metabolic endotoxemia is dictated by the type of lipopolysaccharide., Schertzer JD, Henriksbo BD, Cavallari JF, Barra NG, Anhê FF, Cell reports, 2021, 10.1016/j.celrep.2021.109691
  • The NLRP3 inflammasome regulates adipose tissue metabolism., Schertzer JD, Anhê FF, Henriksbo BD, Barra NG, The Biochemical journal, 2020, 10.1042/bcj20190472
  • The Gut Microbiota as a Mediator of Metabolic Benefits after Bariatric Surgery., Marette A, Schertzer JD, Varin TV, Anhê FF, Canadian journal of diabetes, 2017, 10.1016/j.jcjd.2017.02.002
  • Gnotobiotic mice housing conditions critically influence the phenotype associated with transfer of faecal microbiota in a context of obesity, Fernando Forato Anhê, Gut, 2022, 10.1136/gutjnl-2021-326475
  • Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice, Schertzer JD, Sloboda DM, Miller MS, Stacey HD, Wallace JG, Paniccia G, Anhê FF, Barra NG, Tamrakar AK, Duggan BM, 2021, 10.1101/2021.07.15.452537
  • Loss of OcaB Prevents Age-Induced Fat Accretion and Insulin Resistance by Altering B-Lymphocyte Transition and Promoting Energy Expenditure., Picard F, Deshaies Y, Lacombe J, Lefebvre JS, Drolet MC, Blais-Lecours P, Lavoie-Charland E, Anhê FF, St-Pierre P, Sallé-Lefort S, Caron A, Miard S, Carter S, Diabetes, 2018, 10.2337/db17-0558
  • Triggering Akkermansia with dietary polyphenols: A new weapon to combat the metabolic syndrome?, Marette A, Levy E, Desjardins Y, Roy D, Pilon G, Anhê FF, Gut microbes, 2016, 10.1080/19490976.2016.1142036

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/04
  • Mélanie Juliette Le Moing - Doctorat - En cours
  • Andrea Carolina Arroyave Saldarriaga - Maîtrise avec mémoire - En cours
  • Eya Sellami - Maîtrise avec mémoire - En cours

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Médecine moléculaire

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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