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François Berthod

Professeur titulaire

François Berthod
Francois.Berthod@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche en organogenèse expérimentale
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire
Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
  • Peau
  • Affections cutanées
  • Maladies des tissus conjonctifs
  • Maladies musculaires
  • Tissu conjonctif
Maladies infectieuses et immunitaires
  • Brûlure et infection
  • Maladies auto-immunes
Neurosciences, santé mentale et toxicomanies
  • Greffes neuronales et cellules souches
  • Maladies du système nerveux périphérique
  • Maladies neurodégénératives
  • Maladies de la moelle épinière
  • Maladies neuromusculaires
  • Système moteur
  • Système somato-sensoriel
  • Ataxies

Projets de recherche

  • Organogenèse de muqueuse nasale autologue pour la reconstruction endoscopique endonasale en chirurgie de la base du crâne - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-10-01 au 2028-09-30
  • Depicting disease heterogeneity in neurofibromatosis type 1 and the role of dermal fibroblasts in the establishment of microenvironment favouring NF1-associated skin tumor formation using personalized tissue-engineered 3D models - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-10-01 au 2028-09-30
  • Modélisation par génie tissulaire du rôle du système nerveux sensoriel dans la rosacée - MITACS Inc. - Accélération Québec (MITACS et gouvernement provincial), chercheur principal - 2024-02-05 au 2027-04-04
  • Réparation des lésions des nerfs périphériques par génie tissulaire - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2021-04-01 au 2026-03-31
  • Breaking barriers in drug delivery via using viscoplastic fluids for precise control of jet evolution and penetration - Secrétariat des programmes interorganismes à l’intention des établissements - Fonds Nouvelle frontières en recherche - Volet Transformation, co-chercheur - 2024-04-01 au 2026-03-31
  • Un environnement sécuritaire pour des animaux immunosupprimés - Fondation Canadienne pour l'innovation (La), Centre hospitalier universitaire de Québec - Université Laval, Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), co-chercheur - 2023-01-01 au 2024-05-24
  • Depicting disease heterogeneity in neurofibromatosis type 1 and the role of microenvironment in NF1-associated skin tumor formation through personalized tissue-engineered 3D models - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-03-01 au 2024-02-29
  • Conversion directe de fibroblastes en cellules de Schwann pour stimuler la réparation des nerfs périphériques - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, Université de Montréal, co-chercheur - 2022-04-01 au 2023-03-31
  • Étude de l'impact de l'innervation cutanée dans le Psoriasis - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-04-01 au 2023-03-31
  • Modélisation par génie tissulaire de la modulation de l'angiogenèse par l'innervation sensorielle - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2018-04-01 au 2023-03-31

Publications

  • Differential Expression of Collagens XII and XIV in Human Skin and in Reconstructed Skin, François A. Auger, Michel van der Rest, Odile Damour, Robert Garrone, Claire Lethias, Rina Guignard, Lucie Germain, François Berthod, Journal of Investigative Dermatology, 1997, 10.1111/1523-1747.ep12292122
  • Characterization of Skin Reconstructed on a Chitosan-Cross-Linked Collagen-Glycosaminoglycan Matrix, Christian Collombel, Odile Damour, François Berthod, Lili Shahabeddin, Skin Pharmacology and Physiology, 1990, 10.1159/000210857
  • Quantitative Method to Evaluate the Functionality of the Trigeminal Nerve, François Berthod, Marie-France Champigny, Robert Paquin, Pierre-Éric Landry, René Caissie, Journal of Oral and Maxillofacial Surgery, 2007, 10.1016/j.joms.2006.09.010
  • Tissue-engineered skin and the treatment of burns: Skin doctor, Berthod, F., Biochemist, 2007
  • Fibroblasts and endothelial cells: The basic angiogenic unit, Berthod, F., Angiogenesis: Insights from a Systematic Overview, 2013
  • Collagen-Based Biomaterials for Tissue Engineering Applications, François Berthod, Robert Gauvin, Rémi Parenteau-Bareil, Materials, 2010, 10.3390/ma3031863
  • Spontaneous fibroblast-derived pericyte recruitment in a human tissue-engineered angiogenesis model in vitro, François A. Auger, Jeffrey A. Medin, Nathalie Tremblay, Julie Symes, François Berthod, Journal of Cellular Physiology, 2012, 10.1002/jcp.22943
  • Inosculation of Tissue-Engineered Capillaries with the Host's Vasculature in a Reconstructed Skin Transplanted on Mice, Francois A. Auger, Lucie Germain, Francois Berthod, Valerie Hudon, Pierre-Luc Tremblay, American Journal of Transplantation, 2005, 10.1111/j.1600-6143.2005.00790.x
  • Potential of tissue engineering and neural stem cells in the understanding and treatment of neurodegenerative diseases, Berthod, F., Auclair-Daigle, C., Stem Cell and Tissue Engineering, 2011, 10.1142/9789814317061_0016
  • Collagen synthesis by fibroblasts cultured within a collagen sponge, Christian Collombel, Odile Damour, Dany Hayek, François Berthod, Biomaterials, 1993, 10.1016/0142-9612(93)90039-5
  • Nerve regeneration in a collagen–chitosan tissue-engineered skin transplanted on nude mice, François Berthod, Isabelle Paradis, Marie Gingras, Biomaterials, 2003, 10.1016/s0142-9612(02)00572-0
  • Improvement of Nerve Regeneration in Tissue-Engineered Skin Enriched with Schwann Cells, François Berthod, Myriam Grenier, Mathieu Blais, Journal of Investigative Dermatology, 2009, 10.1038/jid.2009.159
  • In vitro development of a tissue-engineered model of peripheral nerve regeneration to study neurite growth , FRANÇOIS BERTHOD, HEATHER D. DURHAM, JULIEN DÉRY, JULIE BERGERON, MARIE GINGRAS, The FASEB Journal, 2003, 10.1096/fj.02-1180fje
  • Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling, Saghatelyan, A., Parent, A., Barker, P.A., Götz, M., Berthod, F., Gravel, C., Ninkovic, J., Massouh, M., Blais, M., Brill, M.S., Lemasson, M., Snapyan, M., Journal of Neuroscience, 2009, 10.1523/JNEUROSCI.4956-08.2009
  • Principles of Living Organ Reconstruction by Tissue Engineering, Franc¸ois Auger, Francine Goulet, Véronique Moulin, François Berthod, Lucie Germain, Tissue Engineering And Novel Delivery Systems, 2003, 10.1201/9780203913338.ch10
  • Nerve Growth Factor, Brain-Derived Neurotrophic Factor, Neurotrophin-3 and Glial-Derived Neurotrophic Factor Enhance Angiogenesis in a Tissue-Engineered In Vitro Model, François Berthod, Sabrina Bellenfant, Philippe Lévesque, Mathieu Blais, Tissue Engineering Part A, 2013, 10.1089/ten.tea.2012.0745
  • Deposition of collagen fibril bundles by long-term culture of fibroblasts in a collagen sponge, Collombel, C., Damour, O., Hayek, D., Sahuc, F., Berthod, F., Journal of Biomedical Materials Research, 1996, 10.1002/(SICI)1097-4636(199609)32:1<87::AID-JBM10>3.0.CO;2-F
  • Modélisation in vitro du système nerveux par génie tissulaire, , médecine/sciences, 2009, 10.1051/medsci/2009253288
  • Le génie tissulaire au service de la compréhension du vivant, François A. Auger, Lucie Germain, François Berthod, Francine Goulet, Véronique Moulin, médecine/sciences, 2003, 10.1051/medsci/200319101003
  • Tissue-engineered human skin substitutes developed from collagen-populated hydrated gels: Clinical and fundamental applications, Germain, L., Moulin, V., Berthod, F., Goulet, F., Rouabhia, M., Auger, F.A., Medical and Biological Engineering and Computing, 1998, 10.1007/BF02518887
  • Neuropeptide Substance P Released from a Nonswellable Laponite-Based Hydrogel Enhances Wound Healing in a Tissue-Engineered Skin In Vitro, François Berthod, Catia Ornelas, Carolyne B. Braga, Tiago B. Becher, Thiéry De Serres-Bérard, ACS Applied Polymer Materials, 2020, 10.1021/acsapm.0c01034
  • High yield extraction of pure spinal motor neurons, astrocytes and microglia from single embryo and adult mouse spinal cord, François Berthod, François Gros-Louis, Sabrina Bellenfant, Mathieu Blais, Sébastien Cadau, Qiurui Yang, Marie-Josée Beaudet, Scientific Reports, 2015, 10.1038/srep16763
  • Engineering human tissues for in vivo applications, Auger, F.A., Berthod, F., Moulin, V., Goulet, F., Germain, L., Annals of the New York Academy of Sciences, 2002, 10.1111/j.1749-6632.2002.tb03099.x
  • Extracellular matrix deposition by fibroblasts is necessary to promote capillary-like tube formation in vitro, François A. Auger, Nathalie Tremblay, Lucie Germain, François Berthod, Journal of Cellular Physiology, 2006, 10.1002/jcp.20584
  • Tissue‐engineered in vitro modeling of the impact of Schwann cells in amyotrophic lateral sclerosis, François Berthod, François Gros‐Louis, Marie‐Josée Beaudet, Aurélie Louit, Biotechnology and Bioengineering, 2022, 10.1002/bit.28083
  • A Longitudinal Low Dose μCT Analysis of Bone Healing in Mice: A Pilot Study, , Advances in Orthopedics, 2014, 10.1155/2014/791539
  • Mesenchymal-epithelial interactions regulate gene expression of type VII collagen and kalinin in keratinocytes and dermal-epidermal junction formation in a skin equivalent model, Christian Collombel, Odile Damour, Francois Berthod, Keiko Nakazawa, Florent Sahuc, Wound Repair and Regeneration, 1996, 10.1046/j.1524-475x.1996.40116.x
  • Use of in Vitro Reconstructed Skin To Cover Skin Flap Donor Site, , Journal of Surgical Research, 1997, 10.1006/jsre.1997.5229
  • Prevascularized Tissue-Engineered Human Vaginal Mucosa: In Vitro Optimization and In Vivo Validation, , Tissue Engineering Part A, 2020, 10.1089/ten.tea.2020.0036
  • Collagen fibril network and elastic system remodeling in a reconstructed skin transplanted on nude mice, François A. Auger, Odile Damour, Wen Xu, Hui Li, Lucie Germain, François Berthod, Matrix Biology, 2001, 10.1016/s0945-053x(01)00162-7
  • The Relation between ALS and the Skin: A Novel Human In Vitro Model to Identify New Biomarkers, Francois Gros Louis, Francois Berthod, Bastien Pare, Journal of Molecular Biomarkers & Diagnosis, 2015, 10.4172/2155-9929.1000e121
  • Tissue-engineered skin substitutes: From in vitro constructs to in vivo applications, Germain, L., Pouliot, R., Moulin, V., Berthod, F., Auger, F.A., Biotechnology and Applied Biochemistry, 2004
  • Cutaneous nociception: Role of keratinocytes, , Experimental Dermatology, 2019, 10.1111/exd.13975
  • In Vitro 3D Modeling of Neurodegenerative Diseases, François Berthod, Todd Galbraith, Aurélie Louit, Bioengineering, 2023, 10.3390/bioengineering10010093
  • Modélisation tridimensionnelle in vitro des systèmes nerveux et immunitaire de la peau, Vincent Flacher, François Berthod, Quentin Muller, médecine/sciences, 2021, 10.1051/medsci/2020260
  • Hair Follicles Guide Nerve Migration In Vitro and In Vivo in Tissue-Engineered Skin, François Berthod, Lucie Germain, Marie Gingras, Rémi Parenteau-Bareil, Danielle Larouche, Vicky Gagnon, Journal of Investigative Dermatology, 2011, 10.1038/jid.2011.34
  • Normal Human Epithelial Cells Regulate the Size and Morphology of Tissue-Engineered Capillaries, Lucie Germain, François A. Auger, François Berthod, Charles J. Roberge, Kathleen Baker, Florence Tomasetig, Véronique Fortin, Julie Fradette, Marie-Hélène Rochon, Tissue Engineering Part A, 2010, 10.1089/ten.tea.2009.0090
  • Potential of tissue engineering and neural stem cells in the understanding and treatment of neurodegenerative diseases, Berthod, F., Auclair-Daigle, C., Engineering Stem Cells For Tissue Regeneration, 2017, 10.1142/10228
  • Concise Review: Tissue-Engineered Skin and Nerve Regeneration in Burn Treatment, François Berthod, Sébastien Cadau, Rémi Parenteau-Bareil, Mathieu Blais, STEM CELLS Translational Medicine, 2013, 10.5966/sctm.2012-0181
  • In vitro glycation of a tissue‐engineered wound healing model to mimic diabetic ulcers, François Berthod, Sébastien Cadau, Sabrina Bellenfant, Thiéry De Serres‐Bérard, Kiefer Thouin, Mathias Lemarchand, Biotechnology and Bioengineering, 2023, 10.1002/bit.28359
  • In vivo enhancement of sensory perception recovery in a tissue-engineered skin enriched with laminin, François Berthod, Marie-France Champigny, Marie Gingras, René Caissie, Biomaterials, 2006, 10.1016/j.biomaterials.2006.01.014
  • Moyamoya Disease Susceptibility Gene RNF213 Regulates Endothelial Barrier Function, , Stroke, 2022, 10.1161/strokeaha.120.032691
  • Repair of peripheral nerve injuries using a prevascularized cell-based tissue-engineered nerve conduit, François Berthod, Hélène T. Khuong, Chantal M. Fauvel, Todd Galbraith, Alexane Thibodeau, Biomaterials, 2022, 10.1016/j.biomaterials.2021.121269
  • Reconstructed skin from co-cultured human keratinocytes and fibroblasts on a chitosane cross-linked collagen-GAG matrix, Collombel, C., Saintigny, G., Rousselle, P., Berthod, F., Damour, O., Shahabeddin, L., Journal of Materials Science: Materials in Medicine, 1991, 10.1007/BF00703375
  • Comparative study of bovine, porcine and avian collagens for the production of a tissue engineered dermis, François Berthod, Lucie Germain, Claude Gariépy, Simon Cliche, Robert Gauvin, Rémi Parenteau-Bareil, Acta Biomaterialia, 2011, 10.1016/j.actbio.2011.06.020
  • In vitro study of axonal migration and myelination of motor neurons in a three-dimensional tissue-engineered model, François Berthod, Heather D. Durham, Vicky Gagnon, Marie-Michèle Beaulieu, Marie Gingras, Glia, 2007, 10.1002/glia.20617
  • In vitro reconstruction of a tissue-engineered endothelialized bladder from a single porcine biopsy, Stéphane Bolduc, Frédéric Soucy, Marie-France Champigny, François Berthod, Martine Magnan, Journal of Pediatric Urology, 2006, 10.1016/j.jpurol.2005.11.019
  • In Vitro Characterization of Motor Neurons and Purkinje Cells Differentiated from Induced Pluripotent Stem Cells Generated from Patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay, François Berthod, Nicolas Dupré, François Gros-Louis, Mathieu Blais, Marie-Josée Beaudet, Aurélie Louit, Stem Cells International, 2023, 10.1155/2023/1496597
  • A dermal substrate made of collagen-GA-chitosan for deep burn coverage: First clinical uses, Collombel, C., Sahuc, F., Berthod, F., Rousselle, P., Berthin-Maghit, M., Gueugniaud, P.Y., Damour, O., Clinical Materials, 1994, 10.1016/0267-6605(94)90057-4
  • In vitro reconstruction of a human capillary-like network in a tissue-engineered skin equivalent, François A. Auger, Lucie Germain, Nicolas L'heureux, François Berthod, Annie F. Black, The FASEB Journal, 1998, 10.1096/fasebj.12.13.1331
  • Optimized protocols for isolation of primary motor neurons, astrocytes and microglia from embryonic mouse spinal cord, François Berthod, Heather D. Durham, Sandra Minotti, Vicky Gagnon, Marie Gingras, Journal of Neuroscience Methods, 2007, 10.1016/j.jneumeth.2007.02.024
  • In vitro reconstructed skin models for wound coverage in deep burns, Damour, O., Berthod, F., British Journal of Dermatology, 1997, 10.1111/j.1365-2133.1997.tb03917.x
  • In vitro evaluation of the angiostatic potential of drugs using an endothelialized tissue-engineered connective tissue, Auger, F.A., Germain, L., Berthod, F., Tremblay, P.-L., Journal of Pharmacology and Experimental Therapeutics, 2005, 10.1124/jpet.105.089524
  • Cutaneous Myiasis: Diagnosis, Treatment, and Prevention, Pierre-Éric Landry, François Berthod, Marjolaine Giroux, Frédéric Beaulieu, René Caissie, Journal of Oral and Maxillofacial Surgery, 2008, 10.1016/j.joms.2007.09.005
  • Early detection of structural abnormalities and cytoplasmic accumulation of TDP-43 in tissue-engineered skins derived from ALS patients, François Gros-Louis, François Berthod, Nicolas Dupré, Guy A Rouleau, Peter Gould, Jean-Pierre Bouchard, Patrick A Dion, Hélène T Khuong, François-Dominique Scott, Marie-Soleil Lamarre, Rémy Lamontagne, Lydia Touzel-Deschênes, Bastien Paré, Acta Neuropathologica Communications, 2015, 10.1186/s40478-014-0181-z
  • Optimization of thickness, pore size and mechanical properties of a biomaterial designed for deep burn coverage, Damour, O., Collombel, C., Hayek, D., Chretien, F., Saintigny, G., Berthod, F., Clinical Materials, 1994, 10.1016/0267-6605(94)90055-8
  • Biotechnological Management of Skin Burn Injuries: Challenges and Perspectives in Wound Healing and Sensory Recovery, Desmoulière, A., Berthod, F., Lataillade, J.-J., Coulomb, B., Misery, L., Egles, C., Alexaline, M.M., Ghazi, K., Trouillas, M., Buhé, V., Laverdet, B., Girard, D., Tissue Engineering - Part B: Reviews, 2017, 10.1089/ten.teb.2016.0195
  • What is new in mechanical properties of tissue-engineered organs., Germain, L., Goulet, F., Berthod, F., Auger, F.A., Current topics in pathology. Ergebnisse der Pathologie, 1999
  • Lifting the veil on the keratinocyte contribution to cutaneous nociception, , Protein & Cell, 2020, 10.1007/s13238-019-00683-9
  • A tissue-engineered endothelialized dermis to study the modulation of angiogenic and angiostatic molecules on capillary-like tube formation in vitro, Auger, F.A., Germain, L., Damour, O., Black, A.F., Berthod, F., Hudon, V., British Journal of Dermatology, 2003, 10.1046/j.1365-2133.2003.05298.x
  • In vitro glycation of an endothelialized and innervated tissue-engineered skin to screen anti-AGE molecules, François Berthod, Valérie André-Frei, Nicolas Bechetoille, Sabine Pain, Sabrina Leoty-Okombi, Sébastien Cadau, Biomaterials, 2015, 10.1016/j.biomaterials.2015.01.066
  • Differentiation of human adult skin-derived neuronal precursors into mature neurons, François Berthod, Marie-France Champigny, Marie Gingras, Journal of Cellular Physiology, 2006, 10.1002/jcp.20889
  • Sensory neurons accelerate skin reepithelialization via substance P in an innervated tissue-engineered wound healing model, Berthod, F., Cadau, S., Bellenfant, S., Mottier, L., Germain, M.-A., Blais, M., Tissue Engineering - Part A, 2014, 10.1089/ten.tea.2013.0535
  • Development of an innervated tissue-engineered skin with human sensory neurons and Schwann cells differentiated from iPS cells, François Berthod, Vincent Flacher, Sabrina Bellenfant, Thiéry De Serres-Bérard, Marie-Josée Beaudet, Quentin Muller, Acta Biomaterialia, 2018, 10.1016/j.actbio.2018.10.011

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Gérald Guillebaud - Doctorat - En cours
  • Oumayma Hayouni - Doctorat - En cours
  • Rémy Pépin - Doctorat - En cours
  • Mathias Lemarchand - Doctorat - En cours
  • Alexane Thibodeau - Doctorat - En cours
  • Emilie Genin - Doctorat - En cours
  • Audrey Labarre - Maîtrise avec mémoire - 2014/09
  • Lorène Mottier - Maîtrise avec mémoire - 2014/09
  • Kiefer Thouin - Maîtrise avec mémoire - 2017/01
  • Thiéry De Serres-Bérard - Maîtrise avec mémoire - 2019/01
  • Quentin Muller - Doctorat - 2019/01
  • Bastien Paré - Doctorat - 2019/05
  • Julien Ringuet - Maîtrise avec mémoire - 2019/09
  • Aurélie Louit - Doctorat - 2021/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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