Découvrez nos professeurs et professeures!

Revenir au répertoire
Fiche précédente
Fiche suivante

François Bordeleau

Professeur agrégé

François Bordeleau
francois.bordeleau@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en organogenèse expérimentale
Partager la fiche :

Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Oncologie
Bioinformatique / données massives (big data)
Médecine régénératrice et médecine moléculaire

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Cancer la prostate
  • Cancer du sein
  • Carcinogénèse
  • Diagnostic et détection du cancer
  • Signalisation cellulaire et cancer
  • Facteurs de croissance
  • Génétique du cancer
Cellulaire
  • Cellule
Subcellulaire
Génomique et protéomique
  • Bio-informatique
  • Biotechnologie
  • Mécanismes biologiques et biochimiques
  • Technologies biomédicales
Organisation et fonctions biologiques
Organismes vivants (êtres humains - Psychologie/aspects biologiques)
Outils mathématiques et informatiques
  • Analyse mathématique
  • Analyse numérique
  • Modélisation et simulation
  • Approche théorique
Outils de caractérisation
  • Imagerie
  • Propriétés rhéologiques

Projets de recherche

  • Protein glycation acts as a substrate-dependent tumorigenic molecular switch in prostate cancer - Instituts de recherche en santé du Canada - Subvention Projet, Institut de recherche du Centre universitaire de santé McGill, co-chercheur - 2022-04-01 au 2027-03-31
  • Creating a biomimetic 3D engineered model of the liver metastatic niche - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, chercheur principal - 2024-03-31 au 2026-03-30
  • Canada Research Chair in Tumor Mechanoregulation - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2025-06-30
  • Mise en place de la plateforme d'ingénierie tissulaire en cancer - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux, Advanced Solutions - Fonds d'innovation (FI), chercheur principal - 2023-07-01 au 2025-03-31
  • Programme de soutien aux nouveaux détenteurs de CRC - Université Laval - Fonds internes - Fonds de soutien aux professeurs-chercheurs bénéficiant d’une Chaire de recherche du Canada, chercheur principal - 2022-05-01 au 2024-04-30
  • Hepatic stellate cells as a driver of the pre-metastatic niche in uveal melanoma - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-03-01 au 2024-02-29
  • Thérapie photodynamique véctorisée du cancer de la vessie: étude sur un modèle 3D reconstruit par génie tissulaire - Fonds de recherche du Québec - Nature et technologies - Programme Samuel-De Champlain, chercheur principal - 2021-04-01 au 2023-03-31
  • The combined role of cellular force dynamics and extracellular matrix mechanical properties in driving angiogenesis - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2018-04-01 au 2023-03-31
  • Exploration of a novel therapeutic strategy impeding triple-negative breast cancer growth and progression - Fondation de l'Université Laval, co-chercheur - 2022-04-01 au 2023-03-31
  • Toward elucidating the interplay between cell contractility state, mechanotransduction and alternative splicing during tumor progression - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-03-01 au 2023-02-28

Publications

  • Subcellular regulation of cancer cell mechanics, Reinhart-King, C.A., Bordeleau, F., Zanotelli, M.R., Current Opinion in Biomedical Engineering, 2017, 10.1016/j.cobme.2017.02.001
  • ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression, Sabine Elowe, François Bordeleau, Laurence Descombes, Alexsandro Dos Santos, Suparba Roy, Romain Devillers, Chantal Garand, Annie Lauzier, Eva Calvo, Diogjena Katerina Prifti, 2024, 10.1101/2024.04.14.589449
  • Matrix stiffness regulates vascular integrity through focal adhesion kinase activity, Reinhart-King, C.A., Bordeleau, F., Lollis, E.M., Wang, W., FASEB Journal, 2019, 10.1096/fj.201800841R
  • Phenotypic heterogeneity and metastasis of breast cancer cells, Reinhart-King, C.A., King, M.R., Li, J., Richardson, I.M., Marshall, J.R., Bordeleau, F., Lampi, M.C., Goldblatt, Z.E., McArdle, T.J., Ortiz-Otero, N., Mosier, J.A., Wang, W., Taufalele, P.V., Schwager, S.C., Carey, S.P., Hapach, L.A., Cancer Research, 2021, 10.1158/0008-5472.CAN-20-1799
  • Energetic regulation of coordinated leader–follower dynamics during collective invasion of breast cancer cells, Reinhart-King, C.A., Bordeleau, F., Taufalele, P.V., Wang, W., Goliwas, K.F., Zhang, J., Proceedings of the National Academy of Sciences of the United States of America, 2019, 10.1073/pnas.1809964116
  • Cancer-Associated Fibroblasts in a 3D Engineered Tissue Model Induce Tumor-like Matrix Stiffening and EMT Transition, François Bordeleau, Stéphane Bolduc, Frédéric Pouliot, Marc-Étienne Huot, Stéphane Chabaud, Geneviève Bernard, Cassandra Ringuette Goulet, Enola Bollmann, Martial Millet, Cancers, 2022, 10.3390/cancers14153810
  • Coordination of non-professional efferocytosis and actomyosin contractility during epithelial tissue morphogenesis, Bouchard, M., Khadra, A., Bordeleau, F., Côté, J.-F., Tran, V., Schindler, M., Homsy, K., Luthold, C., Graham-Paquin, A.-L., Ponsin, K., Tang, Y.C., Cell Reports, 2023, 10.1016/j.celrep.2023.112202
  • Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility, Reinhart-King, C.A., Cerione, R.A., Lampi, M.C., Antonyak, M.A., Chan, B., Bordeleau, F., Journal of Biomechanics, 2016, 10.1016/j.jbiomech.2015.10.003
  • Adenoviral protein E4orf4 interacts with the polarity protein par3 to induce nuclear rupture and tumor cell death, Lavoie, J.N., Huot, M.-É., Bordeleau, F., Richard, D.E., Laprise, P., Lambert, H., Fuchs, M., Bergeman, J., Boulanger, M.-C., Jacquet, K., Caillier, A., Rodrigue, M.-A., Dziengelewski, C., Journal of Cell Biology, 2020, 10.1083/JCB.201805122
  • Coupling Microfluidic Platforms, Microfabrication, and Tissue Engineered Scaffolds to Investigate Tumor Cells Mechanobiology, Francois Bordeleau, Carole Luthold, Raoua Ben Messaoud, Martial Millet, Micromachines, 2019, 10.3390/mi10060418
  • Substrate stiffness regulates focal adhesion kinase alternative splicing in breast cancer, Bordeleau, F., Hussein, S., Khelifi, G., Bourriquen, G., Luthold, C., Pic, E., Millet, M., Biophysical journal, 2023, 10.1016/j.bpj.2022.11.1533
  • Beneficial Effects of Exercise on Subendothelial Matrix Stiffness are Short-Lived, Reinhart-King, C.A., Putnam, D., Azar, J., Ma, J., Modi, S., Watkins, H.C., Miller, J., Bordeleau, F., Kohn, J.C., Journal of Biomechanical Engineering, 2018, 10.1115/1.4039579
  • Tuning cell migration: Contractility as an integrator of intracellular signals from multiple cues [version 1; referees: 2 approved], Reinhart-King, C.A., Bordeleau, F., F1000Research, 2016, 10.12688/F1000RESEARCH.7884.1
  • High type I collagen density fails to increase breast cancer stem cell phenotype, Vanessa M. Freitas, Cynthia A. Reinhart-King, Murilo V. Geraldo, Karen S.C. Borbely, Luciana M. Dzik, François Bordeleau, Ana Carolina L. Ralph, Iuri C. Valadão, PeerJ, 2020, 10.7717/peerj.9153
  • Measurement of dynamic cell-induced 3D displacement fields in vitro for traction force optical coherence microscopy, Adie, S.G., Reinhartking, C.A., Bordeleau, F., Mulligan, J.A., Biomedical Optics Express, 2017, 10.1364/BOE.8.001152
  • Regulation of ATP utilization during metastatic cell migration by collagen architecture, Reinhart-King, C.A., King, M.R., Lampi, M.C., VanderBurgh, J.A., Li, J., Bordeleau, F., Miller, J.P., Goldblatt, Z.E., Zanotelli, M.R., Molecular Biology of the Cell, 2018, 10.1091/mbc.E17-01-0041
  • Photonic force microscopy of local tension at cell surface focal adhesions, Sheng, Y., Marceau, N., Bessard, J., Bordeleau, F., Proceedings of SPIE - The International Society for Optical Engineering, 2006, 10.1117/12.706573
  • Keratin 8/18 regulation of cell stiffness-extracellular matrix interplay through modulation of rho-mediated actin cytoskeleton dynamics, Marceau, N., Sheng, Y., Lapierre, M.-E., Bordeleau, F., PLoS ONE, 2012, 10.1371/journal.pone.0038780
  • Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis, Cynthia A. Reinhart-King, Richard A. Cerione, Marc A. Antonyak, Francois Bordeleau, Anissa L. Jayathilake, Wenjun Wang, Tanner J. McArdle, Jenna A. Mosier, Caroline M. Carlson, Lauren A. Hapach, Samantha C. Schwager, 2021, 10.1101/2021.10.27.466095
  • Topographical guidance of 3D tumor cell migration at an interface of collagen densities, Reinhart-King, C.A., Tang, L.N., Bordeleau, F., Physical Biology, 2013, 10.1088/1478-3975/10/6/065004
  • Matrix stiffening promotes a tumor vasculature phenotype, Reinhart-King, C.A., Weiss, R.S., Butcher, J.T., Bonassar, L.J., Hassane, D.C., Abril, Y.L.N., Mencia-Trinchant, N., Huynh, J., LaValley, D.J., Montague, C., Califano, J.P., Somasegar, S., Zanotelli, M.R., Mazzola, M., Lollis, E.M., Mason, B.N., Bordeleau, F., Proceedings of the National Academy of Sciences of the United States of America, 2017, 10.1073/pnas.1613855114
  • Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization, Huang, X.-Y., Zhang, J.J., Reinhart-King, C.A., Bordeleau, F., Liu, B., Huang, J., Xing, B., Han, S., Huang, F.-K., Nature Communications, 2015, 10.1038/ncomms8465
  • Substrate stiffness regulates PDGF-induced circular dorsal ruffle formation through MLCK, Reinhart-King, C.A., Kraning-Rush, C.M., Bordeleau, F., Huynh, J., Cellular and Molecular Bioengineering, 2013, 10.1007/s12195-013-0278-7
  • Probing the Biophysical Properties of Primary Breast Tumor-Derived Fibroblasts, Reinhart-King, C.A., Shin, S.J., Varma, S., Somasegar, S., Kowal, D.R., Lampi, M.C., Carey, S.P., Bordeleau, F., Alcoser, T.A., Cellular and Molecular Bioengineering, 2015, 10.1007/s12195-014-0360-9
  • Vinculin regulates directionality and cell polarity in two-And three-dimensional matrix and three-dimensional microtrack migration, Reinhart-King, C.A., García, A.J., Lin, D.Y., Lampi, M.C., Bordeleau, F., Goldblatt, Z.E., Kraning-Rush, C.M., Carey, S.P., Rahman, A., Molecular Biology of the Cell, 2016, 10.1091/mbc.E15-06-0432
  • Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors, Anseth, K.S., Reinhart-King, C.A., Weiss, R.S., Shin, S.J., LaValley, D.J., Mason, B.N., Abril, Y.L.N., Califano, J.P., Bordeleau, F., Proceedings of the National Academy of Sciences of the United States of America, 2015, 10.1073/pnas.1505421112
  • Extent of Cell Confinement in Microtracks Affects Speed and Results in Differential Matrix Strains, Cynthia A. Reinhart-King, Brenton D. Hoffman, Francois Bordeleau, Jacob A. VanderBurgh, Matthew R. Zanotelli, Aniqua Rahman-Zaman, Jenna A. Mosier, Biophysical Journal, 2019, 10.1016/j.bpj.2019.09.024
  • Quantitative assessment of cell contractility using polarized light microscopy, Francois Bordeleau, Cynthia A. Reinhart‐King, Susan C. Pannullo, Joseph P. Miller, Wenjun Wang, Journal of Biophotonics, 2018, 10.1002/jbio.201800008
  • Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation, Antonyak, M.A., Cerione, R.A., Reinhart-King, C.A., Bordeleau, F., Desrochers, L.M., Nature Communications, 2016, 10.1038/ncomms11958
  • Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis, Reinhart-King, C.A., Cerione, R.A., Antonyak, M.A., Bordeleau, F., Bates, M.E., Jayathilake, A.L., Schunk, C., Wang, W., McArdle, T.J., Mosier, J.A., Carlson, C.M., Hapach, L.A., Young, K.M., Schwager, S.C., eLife, 2022, 10.7554/ELIFE.74433
  • Vascular smooth muscle cell matrix-degradation by podosomes, Reinhart-King, C.A., Bordeleau, F., Kohn, J.C., Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, 2013, 10.1109/NEBEC.2013.151
  • Intermediate Filaments, Bordeleau, F., Gilbert, S., Loranger, A., Marceau, N., Cellular Domains, 2011, 10.1002/9781118015759.ch16
  • Improving fascin inhibitors to block tumor cell migration and metastasis, Huang, X.-Y., Zhang, J.J., Li, W., Reinhart-King, C.A., Bordeleau, F., Xing, B., Liu, B., Huang, J., Han, S., Molecular Oncology, 2016, 10.1016/j.molonc.2016.03.006
  • Author Correction: Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making, Cynthia A. Reinhart-King, Francois Bordeleau, David Erickson, Aadhar Jain, Paul V. Taufalele, Jacob A. VanderBurgh, Aniqua Rahman-Zaman, Matthew R. Zanotelli, Nature Communications, 2019, 10.1038/s41467-019-13655-8
  • Keratin contribution to cellular mechanical stress response at focal adhesions as assayed by laser tweezers, Marceau, N., Sheng, Y., Bessard, J., Bordeleau, F., Biochemistry and Cell Biology, 2008, 10.1139/O08-076
  • Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making, Cynthia A. Reinhart-King, Francois Bordeleau, David Erickson, Aadhar Jain, Paul V. Taufalele, Jacob A. VanderBurgh, Aniqua Rahman-Zaman, Matthew R. Zanotelli, Nature Communications, 2019, 10.1038/s41467-019-12155-z
  • Extracellular Vesicles from Ocular Melanoma Have Pro-Fibrotic and Pro-Angiogenic Properties on the Tumor Microenvironment, Solange Landreville, Alain Brisson, François Bordeleau, Julie Bérubé, Nathan Schoonjans, Enola Bollmann, Amel Ben Anes, Andrew Mitchell, Kelly Coutant, Léo Piquet, Cells, 2022, 10.3390/cells11233828
  • Chaperone-Assisted Mitotic Actin Remodeling by BAG3 and HSPB8 Involves the Deacetylase HDAC6 and Its Substrate Cortactin, Josée N. Lavoie, François Bordeleau, Herman Lambert, Alice-Anaïs Varlet, Carole Luthold, International Journal of Molecular Sciences, 2020, 10.3390/ijms22010142
  • The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance?, François Bordeleau, David P. Labbé, Tarek Hallal, Carole Luthold, Cancers, 2022, 10.3390/cancers14122887
  • Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA, Reinhart-King, C.A., Bordeleau, F., Rowe, M.M., Schunk, C.T., Berestesky, E.D., Smart, K., Homsy, K., Millet, M., Taufalele, P.V., Wang, W., Cell Reports, 2023, 10.1016/j.celrep.2023.112338
  • Traction force microscopy for noninvasive imaging of cell forces, Adie, S.G., Reinhart-King, C.A., Bordeleau, F., Mulligan, J.A., Advances in Experimental Medicine and Biology, 2018, 10.1007/978-3-319-95294-9_15
  • Synergic Interactions Between Hepatic Stellate Cells and Uveal Melanoma in Metastatic Growth, Solange Landreville, François Bordeleau, Peter R. A. Gerges, Julie Bérubé, Martial Millet, Nathan Schoonjans, Louise Dewit, Léo Piquet, Cancers, 2019, 10.3390/cancers11081043
  • Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior, Reinhart-King, C.A., King, M.R., Mitchell, M.J., Mason, B.N., Zhou, A.L., Bordeleau, F., Zhou, D.W., Kohn, J.C., Biophysical Journal, 2015, 10.1016/j.bpj.2014.12.023
  • Matrix stiffness regulates microvesicle-induced fibroblast activation, Reinhart-King, C.A., Cerione, R.A., Antonyak, M.A., Zhang, J., Bordeleau, F., Schwager, S.C., American Journal of Physiology - Cell Physiology, 2019, 10.1152/ajpcell.00418.2018
  • Physical biology in cancer. 5. The rocky road of metastasis: The role of cytoskeletal mechanics in cell migratory response to 3D matrix topography, Reinhart-King, C.A., Alcoser, T.A., Bordeleau, F., American Journal of Physiology - Cell Physiology, 2014, 10.1152/ajpcell.00283.2013
  • Measuring integrated cellular mechanical stress response at focal adhesions by optical tweezers, Shenga, Y., Marceau, N., Bessard, J., Bordeleau, F., Journal of Biomedical Optics, 2011, 10.1117/1.3626864
  • Clinical doses of radiation reduce collagen matrix stiffness, Reinhart-King, C.A., Pannullo, S.C., Bonassar, L.J., Parker, D.J., Lavalley, D.J., Zanotelli, M.R., Bordeleau, F., Borde, B.H., Miller, J.P., APL Bioengineering, 2018, 10.1063/1.5018327
  • Simvastatin ameliorates matrix stiffness-mediated endothelial monolayer disruption, Reinhart-King, C.A., Zanotelli, M.R., Bordeleau, F., Huynh, J., Faber, C.J., Lampi, M.C., PLoS ONE, 2016, 10.1371/journal.pone.0147033
  • Using Machine Learning to Predict TP53 Mutation Status and Aggressiveness of Prostate Cancer from Routine Histology Images, François Bordeleau, Cancer Research, 2023, 10.1158/0008-5472.CAN-23-1856
  • Keratin 8/18 modulation of protein kinase C-mediated integrin-dependent adhesion and migration of liver epithelial cells, Marceau, N., Loranger, A., Gilbert, S., Galarneau, L., Bordeleau, F., Molecular Biology of the Cell, 2010, 10.1091/mbc.E09-05-0373
  • Tension directs cancer cell migration over fiber alignment through energy minimization, Cynthia A. Reinhart-King, Francois Bordeleau, Elise Tahon, Ismael Ortiz, Wenjun Wang, Joseph P. Milleri, Matthew R. Zanotelli, Biomaterials, 2024, 10.1016/j.biomaterials.2024.122682
  • Tissue transglutaminase 2 regulates tumor cell tensional homeostasis by increasing contractility, Cynthia A. Reinhart-King, Richard A. Cerione, Marc A. Antonyak, Alysha Simmons, Wenjun Wang, Francois Bordeleau, Journal of Cell Science, 2020, 10.1242/jcs.231134
  • Antigen detection at atomolar concentration using an optical tweezers, Sheng, Y., Marceau, N., Bordeleau, F., Laliberté, M., Proceedings of SPIE - The International Society for Optical Engineering, 2009, 10.1117/12.839769
  • Matrix stiffness enhances cancer-macrophage interactions and M2-like macrophage accumulation in the breast tumor microenvironment, Reinhart-King, C.A., Bordeleau, F., Hassane, D.C., Lau, K.S., King, M.R., Greenlee, J.D., Chen, B., Southard-Smith, A.N., Simmons, A.J., Wang, W., Taufalele, P.V., Acta Biomaterialia, 2023, 10.1016/j.actbio.2022.04.031

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Olivier Chancy - Doctorat - En cours
  • Kevin Homsy - Maîtrise avec mémoire - En cours
  • Juliette Gouhier - Doctorat - En cours
  • Laurence Carignan - Maîtrise avec mémoire - En cours
  • Félix-Antoine Pellerin - Maîtrise avec mémoire - En cours
  • Martial Millet - Doctorat - En cours
  • Mathilde Lavigne - Doctorat - En cours
  • Nafiseh Sadat Mousavi Maleki - Maîtrise avec mémoire - En cours
  • Elise Jeanne Marie Tahon - Doctorat - En cours
  • Seyed Mohammad Reza Rafieipour Alavi - Post-doctorat - En cours
  • Enola Bollmann - Maîtrise avec mémoire - 2023/01

Encadrement d'étudiant(e)s pour les programmes suivants :

Disponibilité d'encadrement d'étudiant(e)s

Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.

Envoyer un courriel
*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
Mettre à jour mon profil de professeur(e)