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Frédéric Bretzner
Professeur titulaire
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
Contribution à la recherche
Thématiques de recherche de la Faculté de médecine
- Médecine régénératrice et médecine moléculaire
- Neurosciences et santé mentale
Domaines de recherche
- Neurosciences, aspects médicaux, physiologiques, et de la santé, n.c.a.
- Neurogenèse et plasticité, aspects médicaux et de la santé
- Troubles neurologiques (sauf les maladies neuromusculaires)
- Neurosciences sensorimotrices
- Neurodéveloppement
- Neurophysiologie
- Neurobiologie animale
- Électrophysiologie
- Excitabilité neuronale et synapses
- Animaux génétiquement modifiés
Projets de recherche en cours
- Role of DSCAM in the development and maintenance of motor circuits - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2024-04-01 au 2029-03-31
- Genetic dissection of propriospinal interneuronal pathways and their reticulospinal inputs pertaining to locomotor control and recovery after spinal cord injury - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-10-01 au 2028-09-30
- Functional contribution of mesencephalic locomotor region nuclei to locomotor recovery after spinal cord injury - Brain Canada Foundation - 2020 Turnbull-Tator Award in Spinal Cord Injury and Concussion Research, chercheur principal - 2025-01-01 au 2026-12-31
- Functional contribution of Mesencephalic Locomotor Region nuclei in chronic Parkinson’s disease - Parkinson Canada - Pilot Project Grant, chercheur principal - 2025-01-01 au 2025-12-31
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Financements des 2 dernières années
- Distinct functional contribution of Sub-Thalamic Locomotor Region nuclei to motor control before and after spinal cord injury - Wings for Life Spinal Cord Research Foundation - Research Grant, chercheur principal - 2023-07-01 au 2025-03-31
- Plasticité et développement du contrôle moteur - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2020-07-01 au 2024-06-30
- Plasticity of midbrain nuclei after spinal cord injury - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-04-01 au 2024-03-31
- Deep brain photometry of spatially distinct brain areas using a single optical fiber - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, chercheur principal - 2022-03-31 au 2024-03-30
- Role of DSCAM in the development of motor circuits - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2018-04-01 au 2023-03-31
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Publications
- Functional plasticity of glutamatergic neurons of medullary reticular nuclei after spinal cord injury in mice, Bretzner, F., Karimi, N., Lemieux, M., Nature Communications, 2024, 10.1038/s41467-024-45300-4
- Focus-tunable microscope for imaging small neuronal processes in freely moving animals, Galstian, T., Bretzner, F., Karimi, N., Rastqar, A., Tabourin, L., Bagramyan, A., bioRxiv, 2020, 10.1101/2020.10.31.363507
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Disruption of estradiol regulation of orexin neurons: a novel mechanism in excessive ventilatory response to CO
2 inhalation in a female rat model of panic disorder, Kinkead, R., Bretzner, F., Henry, M.S., Fournier, S., Tenorio-Lopes, L., Translational Psychiatry, 2020, 10.1038/s41398-020-01076-x - The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice, Planel, E., Bretzner, F., Cicchetti, F., Samadi, P., Morin, F., Bezeau, F., Julien, J., Poitras, I., Truchetti, G., Eyoum Jong, L., Pflieger, M., Petry, F.R., Josset, N., Gratuze, M., Brain Research, 2019, 10.1016/j.brainres.2019.01.016
- Facilitation of locomotor spinal networks activity by buspirone after a complete spinal cord lesion in mice, Leblond, H., Bretzner, F., Josset, N., Jeffrey-Gauthier, R., Journal of Neurotrauma, 2018, 10.1089/neu.2017.5476
- Contribution of the motor cortex to the structure and the timing of hindlimb locomotion in the cat: A microstimulation study, Drew, T., Bretzner, F., Journal of Neurophysiology, 2005, 10.1152/jn.01245.2004
- Age- and speed-dependent modulation of gaits in DSCAM 2J mutant mice, Bretzner, F., Lemieux, M., Thiry, L., Journal of Neurophysiology, 2018, 10.1152/jn.00471.2017
- Motion-less depth-selective optogenetic probe using tapered fiber and an electrically tuneable liquid crystal steering element, Galstian, T., Bretzner, F., Lemieux, M., Boissonneault, W., Biomedical Optics Express, 2025, 10.1364/BOE.544388
- Focus-tunable microscope for imaging small neuronal processes in freely moving animals, Galstian, T., Bretzner, F., Karimi, N., Rastqar, A., Tabourin, L., Bagramyan, A., Photonics Research, 2021, 10.1364/PRJ.418154
- Distinct dampening effects of progesterone on the activity of nucleus tractus solitarii neurons in rat pups, Kinkead, R., Joseph, V., Bretzner, F., Chamberland, S., Boukari, R., Fournier, S., Experimental Physiology, 2019, 10.1113/EP087461
- Speed-dependent modulation of the locomotor behavior in adult mice reveals attractor and transitional gaits, Bretzner, F., Couraud, S., Roussel, M., Josset, N., Lemieux, M., Frontiers in Neuroscience, 2016, 10.3389/fnins.2016.00042
- Using mouse genetics to investigate supraspinal pathways of the brain important to locomotion, Frederic Bretzner, Maxime Lemieux, Marie Roussel, The Neural Control of Movement, 2020, 10.1016/b978-0-12-816477-8.00012-0
- Nogo-A inactivation improves visual plasticity and recovery after retinal injury, Pernet, V., Joly, S., Bretzner, F., Rodriguez, L., Jordi, N., Mdzomba, J.B., Cell Death and Disease, 2018, 10.1038/s41419-018-0780-x
- Motor cortical modulation of cutaneous reflex responses in the hindlimb of the intact cat, Drew, T., Bretzner, F., Journal of Neurophysiology, 2005, 10.1152/jn.01247.2004
- Respiratory manifestations of panic disorder in animals and humans: A unique opportunity to understand how supramedullary structures regulate breathing, Gargaglioni, L., Bretzner, F., Drolet, G., Tenorio, L., Kinkead, R., Respiratory Physiology and Neurobiology, 2014, 10.1016/j.resp.2014.06.013
- Effects of excitation and inactivation in area 17 on paired cells in area 18, Molotchnikoff, S., Shumikhina, S., Itaya, S., Lepore, F., Bretzner, F., Tan, Y.-F., NeuroReport, 2004, 10.1097/00001756-200410050-00006
- Functional characterization of cardiac progenitor cells and their derivatives in the embryonic heart post-chamber formation, Pasumarthi, K.B.S., Brownstone, R.M., Wafa, K., Hong, M., Wilson, J.M., Bretzner, F., Hotchkiss, A., Zhang, F., McMullen, N.M., Developmental Dynamics, 2009, 10.1002/dvdy.22112
- Influence of NO downregulation on oscillatory evoked responses in developing rat superior colliculus, Molotchnikoff, S., Shumikhina, S., Tan, Y.-F., Guillemot, J.-P., Chemtob, S., Bretzner, F., Itaya, S.K., Aïtoubah, J., Developmental Brain Research, 2002, 10.1016/S0165-3806(02)00465-0
- Using mouse genetics to study the developing spinal locomotor circuit, Frederic Bretzner, Maxime Lemieux, Marie Roussel, Louise Thiry, The Neural Control of Movement, 2020, 10.1016/b978-0-12-816477-8.00011-9
- Towards a mini-endoscope design with spatially selective excitation and imaging, Galstian, T., Bretzner, F., Tabourin, L., Biomedical Optics Express, 2024, 10.1364/BOE.512124
- Functional Contribution of Mesencephalic Locomotor Region Nuclei to Locomotor Recovery After Spinal Cord Injury, Bretzner, F., Lemieux, M., Josset, N., Lafrance-Zoubga, D., Roussel, M., SSRN, 2022, 10.2139/ssrn.4201710
- Changes in corticospinal efficacy contribute to the locomotor plasticity observed after unilateral cutaneous denervation of the hindpaw in the cat, Drew, T., Bretzner, F., Journal of Neurophysiology, 2005, 10.1152/jn.00254.2005
- Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype., Frederic Bretzner, Frederic Charron, Robert Brownstone, Fawcett JP, Beaumont E, Marie Roussel, Julien Ferent, Peng J, Lemieux M, Rastqar A, Lemaire C, Thiry L, eNeuro, 2022, 10.1523/eneuro.0216-18.2021
- Comparative computations of spike synchronization in visual cortex of cats, Guillemot, J.-P., Tan, Y.-F., Shumikhina, S., Bretzner, F., Aïtoubah, J., Molotchnikoff, S., Brain Research Protocols, 2001, 10.1016/S1385-299X(00)00050-7
- Using mouse genetics to study the developing spinal locomotor circuit, Bretzner, F., Lemieux, M., Roussel, M., Thiry, L., The Neural Control of Movement: Model Systems and Tools to Study Locomotor Function, 2020, 10.1016/B978-0-12-816477-8.00011-9
- Functional contribution of mesencephalic locomotor region nuclei to locomotor recovery after spinal cord injury, Bretzner, F., Lemieux, M., Josset, N., Lafrance-Zoubga, D., Roussel, M., Cell Reports Medicine, 2023, 10.1016/j.xcrm.2023.100946
- Neonatal maternal separation opposes the facilitatory effect of castration on the respiratory response to hypercapnia of the adult male rat: Evidence for the involvement of the medial amygdala, Kinkead, R., Bretzner, F., Drolet, G., Tremblay, M.-È., Marques, D., Henry, M.S., Tenorio-Lopes, L., Journal of Neuroendocrinology, 2017, 10.1111/jne.12550
- Target populations for first-in-human embryonic stem cell research in spinal cord injury, Brownstone, R.M., Baylis, F., Gilbert, F., Bretzner, F., Cell Stem Cell, 2011, 10.1016/j.stem.2011.04.012
- Motor hypertonia and lack of locomotor coordination in mutant mice lacking DSCAM, Bretzner, F., Frenette, J., Boulanger-Piette, A., Thiry, L., Laflamme, O.D., Lemieux, M., Journal of Neurophysiology, 2016, 10.1152/jn.00556.2015
- Role of DSCAM in the Development of Neural Control of Movement and Locomotion. , Frederic Bretzner, Olivier D. Laflamme, Thiry L, Lemieux M, International journal of molecular sciences, 2021, 10.3390/ijms22168511
- Lightweight mini-endoscope for two color imaging of neural activities with large field of view, Galstian, T., Bretzner, F., Tabourin, L., Results in Optics, 2024, 10.1016/j.rio.2024.100732
- Functional Contribution of Mesencephalic Locomotor Region Nuclei to Locomotor Recovery After Spinal Cord Injury, Bretzner, F., Lemieux, M., Josset, N., Lafrance-Zoubga, D., Roussel, M., bioRxiv, 2022, 10.1101/2022.08.22.504420
- Betacellulin regulates schwann cell proliferation and myelin formation in the injured mouse peripheral nerve, Lacroix, S., Bretzner, F., Côté, D., Filali, M., Schneider, M.R., Thiry, L., Bélanger, E., Wang, L.X., Barrette, B., Vallières, N., GLIA, 2017, 10.1002/glia.23119
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Impact of ovariectomy and CO
2 inhalation on microglia morphology in select brainstem and hypothalamic areas regulating breathing in female rats, Kinkead, R., Fournier, S., Bícego, K.C., Bretzner, F., Joseph, V., Gargaglioni, L.H., Marques, D.A., Brain Research, 2021, 10.1016/j.brainres.2021.147276 - Myeloid dickkopf-1 fuels neurovascular and neuroimmune alterations in ischemic stroke, Gosselin, D., Bretzner, F., Haili, Y., Aldib, N., Manrique-Castano, D., Allain, A.-S., Seigneur, J., Distéfano-Gagné, F., Trudel, E., Lecordier, S., Bernard, M., Menet, R., ElAli, A., Research Square, 2023, 10.21203/rs.3.rs-3189112
- Distinct Contributions of Mesencephalic Locomotor Region Nuclei to Locomotor Control in the Freely Behaving Mouse, Bretzner, F., Rastqar, A., Lafrance-Zoubga, D., Lemieux, M., Roussel, M., Josset, N., Current Biology, 2018, 10.1016/j.cub.2018.02.007
- Using mouse genetics to investigate supraspinal pathways of the brain important to locomotion, Bretzner, F., Lemieux, M., Roussel, M., The Neural Control of Movement: Model Systems and Tools to Study Locomotor Function, 2020, 10.1016/B978-0-12-816477-8.00012-0
- Stimuli outside the classical receptive field modulate the synchronization of action potentials between cells in visual cortex of cats, Molotchnikoff, S., Tan, Y.-F., Shumikhina, S., Aïtoubah, J., Bretzner, F., NeuroReport, 2000, 10.1097/00001756-200004270-00033
- Undesired effects of a combinatorial treatment for spinal cord injury - Transplantation of olfactory ensheathing cells and BDNF infusion to the red nucleus, Tetzlaff, W., Roskams, A.J., Currie, E., Liu, J., Bretzner, F., European Journal of Neuroscience, 2008, 10.1111/j.1460-9568.2008.06462.x
- DSCAM Mutation Impairs Motor Cortex Network Dynamic and Voluntary Motor Functions, Bretzner, F., Thiry, L., Lemieux, M., Laflamme, O.D., Cerebral Cortex, 2019, 10.1093/cercor/bhy097
- Glutamatergic neurons of the gigantocellular reticular nucleus shape locomotor pattern and rhythm in the freely behaving mouse, Bretzner, F., Lemieux, M., PLoS Biology, 2019, 10.1371/journal.pbio.2003880
- Combination of olfactory ensheathing cells with local versus systemic cAMP treatment after a cervical rubrospinal tract injury, Tetzlaff, W., Roskams, A.J., Richter, M., Liu, J., Plemel, J.R., Bretzner, F., Journal of Neuroscience Research, 2010, 10.1002/jnr.22440
- Role of DSCAM in the development of the spinal locomotor and sensorimotor circuits, Bretzner, F., Laflamme, O.D., Lemieux, M., Thiry, L., Journal of Neurophysiology, 2016, 10.1152/jn.00557.2015
- Modulation of the synchronization between cells in visual cortex by contextual targets, Molotchnikoff, S., Tan, Y.-F., Shumikhina, S., Aïtoubah, J., Bretzner, F., European Journal of Neuroscience, 2001, 10.1046/j.0953-816X.2001.01776.x
- Lhx3-Chx10 reticulospinal neurons in locomotor circuits, Brownstone, R.M., Bretzner, F., Journal of Neuroscience, 2013, 10.1523/JNEUROSCI.5231-12.2013
- Schwann cells generated from neonatal skin-derived precursors or neonatal peripheral nerve improve functional recovery after acute transplantation into the partially injured cervical spinal cord of the rat, Tetzlaff, W., Miller, F.D., Liu, J., Borisoff, J., Plunet, W.T., Arisato, H., Jiang, Y., Assinck, P., Biernaskie, J., Bretzner, F., Sparling, J.S., Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.1070-14.2015
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2020/07- Lïa Jeanne Marie Mayet - Maîtrise avec mémoire - En cours
- Abderraouf Redjem - Maîtrise avec mémoire - En cours
- Yasmine Zmantar - Maîtrise avec mémoire - En cours
- Kayvan Combadiere - Maîtrise avec mémoire - En cours
- Quentin Bourgeois - Post-doctorat - En cours
- Marc-Antoine Bouchard - Maîtrise avec mémoire - En cours
- Narges Karimi - Doctorat - En cours
- Marie Roussel - Post-doctorat - En cours
- Baptiste Pierre-Jean Hardoin - Maîtrise avec mémoire - En cours
- Yacine Haili - Maîtrise avec mémoire - 2023/09
- Loïc Tabourin - Doctorat - 2024/01
- Abigaïl Chubwa Ndiku - Maîtrise avec mémoire - 2025/01
Encadrement d'étudiant(e)s
Direction de recherche dans les domaines suivants :
- Neurobiologie — Neurosciences
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Disponibilité d'encadrement d'étudiant(e)s
Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.
Envoyer un courriel*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.