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Frédéric Bretzner

Professeur titulaire

Frédéric Bretzner
frederic.bretzner.1@ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Médecine régénératrice et médecine moléculaire
  • Neurosciences et santé mentale

Domaines de recherche

  • Neurosciences, aspects médicaux, physiologiques, et de la santé, n.c.a.
  • Neurogenèse et plasticité, aspects médicaux et de la santé
  • Troubles neurologiques (sauf les maladies neuromusculaires)
  • Neurosciences sensorimotrices
  • Neurodéveloppement
  • Neurophysiologie
  • Neurobiologie animale
  • Électrophysiologie
  • Excitabilité neuronale et synapses
  • Animaux génétiquement modifiés

Projets de recherche en cours

  • Role of DSCAM in the development and maintenance of motor circuits - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2024-04-01 au 2029-03-31
  • Genetic dissection of propriospinal interneuronal pathways and their reticulospinal inputs pertaining to locomotor control and recovery after spinal cord injury - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-10-01 au 2028-09-30
  • Functional contribution of mesencephalic locomotor region nuclei to locomotor recovery after spinal cord injury - Brain Canada Foundation - 2020 Turnbull-Tator Award in Spinal Cord Injury and Concussion Research, chercheur principal - 2025-01-01 au 2026-12-31
  • Functional contribution of Mesencephalic Locomotor Region nuclei in chronic Parkinson’s disease - Parkinson Canada - Pilot Project Grant, chercheur principal - 2025-01-01 au 2025-12-31

Financements des 2 dernières années

  • Distinct functional contribution of Sub-Thalamic Locomotor Region nuclei to motor control before and after spinal cord injury - Wings for Life Spinal Cord Research Foundation - Research Grant, chercheur principal - 2023-07-01 au 2025-03-31
  • Plasticité et développement du contrôle moteur - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2020-07-01 au 2024-06-30
  • Plasticity of midbrain nuclei after spinal cord injury - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-04-01 au 2024-03-31
  • Deep brain photometry of spatially distinct brain areas using a single optical fiber - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, chercheur principal - 2022-03-31 au 2024-03-30
  • Role of DSCAM in the development of motor circuits - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2018-04-01 au 2023-03-31

Publications

  • Target populations for first-in-human embryonic stem cell research in spinal cord injury, Brownstone, R.M., Baylis, F., Gilbert, F., Bretzner, F., Cell Stem Cell, 2011, 10.1016/j.stem.2011.04.012
  • Motor cortical modulation of cutaneous reflex responses in the hindlimb of the intact cat, Drew, T., Bretzner, F., Journal of Neurophysiology, 2005, 10.1152/jn.01247.2004
  • Glutamatergic neurons of the gigantocellular reticular nucleus shape locomotor pattern and rhythm in the freely behaving mouse, Bretzner, F., Lemieux, M., PLoS Biology, 2019, 10.1371/journal.pbio.2003880
  • DSCAM Mutation Impairs Motor Cortex Network Dynamic and Voluntary Motor Functions, Bretzner, F., Thiry, L., Lemieux, M., Laflamme, O.D., Cerebral Cortex, 2019, 10.1093/cercor/bhy097
  • Using mouse genetics to study the developing spinal locomotor circuit, Bretzner, F., Lemieux, M., Roussel, M., Thiry, L., The Neural Control of Movement: Model Systems and Tools to Study Locomotor Function, 2020, 10.1016/B978-0-12-816477-8.00011-9
  • Stimuli outside the classical receptive field modulate the synchronization of action potentials between cells in visual cortex of cats, Molotchnikoff, S., Tan, Y.-F., Shumikhina, S., Aïtoubah, J., Bretzner, F., NeuroReport, 2000, 10.1097/00001756-200004270-00033
  • Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype., Frederic Bretzner, Frederic Charron, Robert Brownstone, Fawcett JP, Beaumont E, Marie Roussel, Julien Ferent, Peng J, Lemieux M, Rastqar A, Lemaire C, Thiry L, eNeuro, 2022, 10.1523/eneuro.0216-18.2021
  • Undesired effects of a combinatorial treatment for spinal cord injury - Transplantation of olfactory ensheathing cells and BDNF infusion to the red nucleus, Tetzlaff, W., Roskams, A.J., Currie, E., Liu, J., Bretzner, F., European Journal of Neuroscience, 2008, 10.1111/j.1460-9568.2008.06462.x
  • Lightweight mini-endoscope for two color imaging of neural activities with large field of view, Galstian, T., Bretzner, F., Tabourin, L., Results in Optics, 2024, 10.1016/j.rio.2024.100732
  • Influence of NO downregulation on oscillatory evoked responses in developing rat superior colliculus, Molotchnikoff, S., Shumikhina, S., Tan, Y.-F., Guillemot, J.-P., Chemtob, S., Bretzner, F., Itaya, S.K., Aïtoubah, J., Developmental Brain Research, 2002, 10.1016/S0165-3806(02)00465-0
  • Effects of excitation and inactivation in area 17 on paired cells in area 18, Molotchnikoff, S., Shumikhina, S., Itaya, S., Lepore, F., Bretzner, F., Tan, Y.-F., NeuroReport, 2004, 10.1097/00001756-200410050-00006
  • Speed-dependent modulation of the locomotor behavior in adult mice reveals attractor and transitional gaits, Bretzner, F., Couraud, S., Roussel, M., Josset, N., Lemieux, M., Frontiers in Neuroscience, 2016, 10.3389/fnins.2016.00042
  • Functional Contribution of Mesencephalic Locomotor Region Nuclei to Locomotor Recovery After Spinal Cord Injury, Bretzner, F., Lemieux, M., Josset, N., Lafrance-Zoubga, D., Roussel, M., bioRxiv, 2022, 10.1101/2022.08.22.504420
  • Focus-tunable microscope for imaging small neuronal processes in freely moving animals, Galstian, T., Bretzner, F., Karimi, N., Rastqar, A., Tabourin, L., Bagramyan, A., Photonics Research, 2021, 10.1364/PRJ.418154
  • Functional contribution of mesencephalic locomotor region nuclei to locomotor recovery after spinal cord injury, Bretzner, F., Lemieux, M., Josset, N., Lafrance-Zoubga, D., Roussel, M., Cell Reports Medicine, 2023, 10.1016/j.xcrm.2023.100946
  • Functional Contribution of Mesencephalic Locomotor Region Nuclei to Locomotor Recovery After Spinal Cord Injury, Bretzner, F., Lemieux, M., Josset, N., Lafrance-Zoubga, D., Roussel, M., SSRN, 2022, 10.2139/ssrn.4201710
  • Impact of ovariectomy and CO2 inhalation on microglia morphology in select brainstem and hypothalamic areas regulating breathing in female rats, Kinkead, R., Fournier, S., Bícego, K.C., Bretzner, F., Joseph, V., Gargaglioni, L.H., Marques, D.A., Brain Research, 2021, 10.1016/j.brainres.2021.147276
  • The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice, Planel, E., Bretzner, F., Cicchetti, F., Samadi, P., Morin, F., Bezeau, F., Julien, J., Poitras, I., Truchetti, G., Eyoum Jong, L., Pflieger, M., Petry, F.R., Josset, N., Gratuze, M., Brain Research, 2019, 10.1016/j.brainres.2019.01.016
  • Facilitation of locomotor spinal networks activity by buspirone after a complete spinal cord lesion in mice, Leblond, H., Bretzner, F., Josset, N., Jeffrey-Gauthier, R., Journal of Neurotrauma, 2018, 10.1089/neu.2017.5476
  • Disruption of estradiol regulation of orexin neurons: a novel mechanism in excessive ventilatory response to CO2 inhalation in a female rat model of panic disorder, Kinkead, R., Bretzner, F., Henry, M.S., Fournier, S., Tenorio-Lopes, L., Translational Psychiatry, 2020, 10.1038/s41398-020-01076-x
  • Functional plasticity of glutamatergic neurons of medullary reticular nuclei after spinal cord injury in mice, Bretzner, F., Karimi, N., Lemieux, M., Nature Communications, 2024, 10.1038/s41467-024-45300-4
  • Changes in corticospinal efficacy contribute to the locomotor plasticity observed after unilateral cutaneous denervation of the hindpaw in the cat, Drew, T., Bretzner, F., Journal of Neurophysiology, 2005, 10.1152/jn.00254.2005
  • Comparative computations of spike synchronization in visual cortex of cats, Guillemot, J.-P., Tan, Y.-F., Shumikhina, S., Bretzner, F., Aïtoubah, J., Molotchnikoff, S., Brain Research Protocols, 2001, 10.1016/S1385-299X(00)00050-7
  • Using mouse genetics to study the developing spinal locomotor circuit, Frederic Bretzner, Maxime Lemieux, Marie Roussel, Louise Thiry, The Neural Control of Movement, 2020, 10.1016/b978-0-12-816477-8.00011-9
  • Contribution of the motor cortex to the structure and the timing of hindlimb locomotion in the cat: A microstimulation study, Drew, T., Bretzner, F., Journal of Neurophysiology, 2005, 10.1152/jn.01245.2004
  • Schwann cells generated from neonatal skin-derived precursors or neonatal peripheral nerve improve functional recovery after acute transplantation into the partially injured cervical spinal cord of the rat, Tetzlaff, W., Miller, F.D., Liu, J., Borisoff, J., Plunet, W.T., Arisato, H., Jiang, Y., Assinck, P., Biernaskie, J., Bretzner, F., Sparling, J.S., Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.1070-14.2015
  • Using mouse genetics to investigate supraspinal pathways of the brain important to locomotion, Frederic Bretzner, Maxime Lemieux, Marie Roussel, The Neural Control of Movement, 2020, 10.1016/b978-0-12-816477-8.00012-0
  • Betacellulin regulates schwann cell proliferation and myelin formation in the injured mouse peripheral nerve, Lacroix, S., Bretzner, F., Côté, D., Filali, M., Schneider, M.R., Thiry, L., Bélanger, E., Wang, L.X., Barrette, B., Vallières, N., GLIA, 2017, 10.1002/glia.23119
  • Distinct Contributions of Mesencephalic Locomotor Region Nuclei to Locomotor Control in the Freely Behaving Mouse, Bretzner, F., Rastqar, A., Lafrance-Zoubga, D., Lemieux, M., Roussel, M., Josset, N., Current Biology, 2018, 10.1016/j.cub.2018.02.007
  • Motion-less depth-selective optogenetic probe using tapered fiber and an electrically tuneable liquid crystal steering element, Galstian, T., Bretzner, F., Lemieux, M., Boissonneault, W., Biomedical Optics Express, 2025, 10.1364/BOE.544388
  • Age- and speed-dependent modulation of gaits in DSCAM 2J mutant mice, Bretzner, F., Lemieux, M., Thiry, L., Journal of Neurophysiology, 2018, 10.1152/jn.00471.2017
  • Lhx3-Chx10 reticulospinal neurons in locomotor circuits, Brownstone, R.M., Bretzner, F., Journal of Neuroscience, 2013, 10.1523/JNEUROSCI.5231-12.2013
  • Role of DSCAM in the Development of Neural Control of Movement and Locomotion. , Frederic Bretzner, Olivier D. Laflamme, Thiry L, Lemieux M, International journal of molecular sciences, 2021, 10.3390/ijms22168511
  • Using mouse genetics to investigate supraspinal pathways of the brain important to locomotion, Bretzner, F., Lemieux, M., Roussel, M., The Neural Control of Movement: Model Systems and Tools to Study Locomotor Function, 2020, 10.1016/B978-0-12-816477-8.00012-0
  • Neonatal maternal separation opposes the facilitatory effect of castration on the respiratory response to hypercapnia of the adult male rat: Evidence for the involvement of the medial amygdala, Kinkead, R., Bretzner, F., Drolet, G., Tremblay, M.-È., Marques, D., Henry, M.S., Tenorio-Lopes, L., Journal of Neuroendocrinology, 2017, 10.1111/jne.12550
  • Nogo-A inactivation improves visual plasticity and recovery after retinal injury, Pernet, V., Bretzner, F., Joly, S., Rodriguez, L., Jordi, N., Mdzomba, J.B., Cell Death and Disease, 2018, 10.1038/s41419-018-0780-x
  • Combination of olfactory ensheathing cells with local versus systemic cAMP treatment after a cervical rubrospinal tract injury, Tetzlaff, W., Roskams, A.J., Richter, M., Liu, J., Plemel, J.R., Bretzner, F., Journal of Neuroscience Research, 2010, 10.1002/jnr.22440
  • Respiratory manifestations of panic disorder in animals and humans: A unique opportunity to understand how supramedullary structures regulate breathing, Gargaglioni, L., Bretzner, F., Drolet, G., Tenorio, L., Kinkead, R., Respiratory Physiology and Neurobiology, 2014, 10.1016/j.resp.2014.06.013
  • Motor hypertonia and lack of locomotor coordination in mutant mice lacking DSCAM, Bretzner, F., Frenette, J., Boulanger-Piette, A., Thiry, L., Laflamme, O.D., Lemieux, M., Journal of Neurophysiology, 2016, 10.1152/jn.00556.2015
  • Functional characterization of cardiac progenitor cells and their derivatives in the embryonic heart post-chamber formation, Pasumarthi, K.B.S., Brownstone, R.M., Wafa, K., Hong, M., Wilson, J.M., Bretzner, F., Hotchkiss, A., Zhang, F., McMullen, N.M., Developmental Dynamics, 2009, 10.1002/dvdy.22112
  • Modulation of the synchronization between cells in visual cortex by contextual targets, Molotchnikoff, S., Tan, Y.-F., Aïtoubah, J., Shumikhina, S., Bretzner, F., European Journal of Neuroscience, 2001, 10.1046/j.0953-816X.2001.01776.x
  • Focus-tunable microscope for imaging small neuronal processes in freely moving animals, Galstian, T., Bretzner, F., Karimi, N., Rastqar, A., Tabourin, L., Bagramyan, A., bioRxiv, 2020, 10.1101/2020.10.31.363507
  • Distinct dampening effects of progesterone on the activity of nucleus tractus solitarii neurons in rat pups, Kinkead, R., Joseph, V., Bretzner, F., Chamberland, S., Boukari, R., Fournier, S., Experimental Physiology, 2019, 10.1113/EP087461
  • Role of DSCAM in the development of the spinal locomotor and sensorimotor circuits, Bretzner, F., Laflamme, O.D., Lemieux, M., Thiry, L., Journal of Neurophysiology, 2016, 10.1152/jn.00557.2015
  • Towards a mini-endoscope design with spatially selective excitation and imaging, Galstian, T., Bretzner, F., Tabourin, L., Biomedical Optics Express, 2024, 10.1364/BOE.512124
  • Myeloid dickkopf-1 fuels neurovascular and neuroimmune alterations in ischemic stroke, Gosselin, D., Bretzner, F., Haili, Y., Aldib, N., Manrique-Castano, D., Allain, A.-S., Seigneur, J., Distéfano-Gagné, F., Trudel, E., Lecordier, S., Bernard, M., Menet, R., ElAli, A., Research Square, 2023, 10.21203/rs.3.rs-3189112

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/04
  • Yasmine Zmantar - Maîtrise avec mémoire - En cours
  • Narges Karimi - Doctorat - En cours
  • Marie Roussel - Post-doctorat - En cours
  • Quentin Bourgeois - Post-doctorat - En cours
  • Kayvan Combadiere - Maîtrise avec mémoire - En cours
  • Marc-Antoine Bouchard - Maîtrise avec mémoire - En cours
  • Lïa Jeanne Marie Mayet - Maîtrise avec mémoire - En cours
  • Baptiste Pierre-Jean Hardoin - Maîtrise avec mémoire - En cours
  • Yacine Haili - Maîtrise avec mémoire - 2023/09
  • Loïc Tabourin - Doctorat - 2024/01
  • Abigaïl Chubwa Ndiku - Maîtrise avec mémoire - 2025/01

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Neurobiologie — Neurosciences

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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