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Guy Poirier

Professeur titulaire

Guy Poirier
Centre de recherche sur le cancer
Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Projets de recherche

  • Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines - Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université du Québec à Montréal - UQAM , co-chercheur - 2024-04-01 au 2030-03-31
  • Emerging roles of Zinc Finger PAR-Interacting Proteins (ZIPPs) in DNA double-strand break (DSB) repair: implications in PARPi therapy - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2024-04-01 au 2029-03-31
  • Poly(ADP-ribose) writers, readers, and erasers: Functions in DNA double-strand break repair and synthetic lethality - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-10-01 au 2024-09-30
  • Solution d'imagerie cellulaire en temps réel pour améliorer la létalité synthétique des inhibiteurs de PARP dans le traitement du cancer - Ministère de la Santé et des Services sociaux, Fondation Canadienne pour l'innovation (La) - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2021-04-01 au 2022-03-31
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO) - Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, co-chercheur - 2015-04-01 au 2022-03-31

Publications

  • Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1., , Nucleic acids research, 2000, 10.1093/nar/28.20.3887
  • Association of poly(ADP-ribose) polymerase with the nuclear matrix: the role of intermolecular disulfide bond formation, RNA retention, and cell type., , Experimental cell research, 1991, 10.1016/0014-4827(91)90072-3
  • Rearrangements of the nucleosome structure in chromatin by poly(ADP-ribose)., , Biochimica et biophysica acta, 1992, 10.1016/0167-4838(92)90163-8
  • Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells., , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1889
  • Modulation of caspase-3 activity by zinc ions and by the cell redox state., , Experimental cell research, 2001, 10.1006/excr.2001.5222
  • DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair., , Nucleic acids research, 2015, 10.1093/nar/gku1307
  • Aurora-A phosphorylates splicing factors and regulates alternative splicing, Claude Prigent, Erwan Watrin, Juan Valcárcel, Guy G. Poirier, Agnès Mereau, Justine Cailloce, Thibault Courtheoux, Estefania Mancini, Malgorzata Ewa Rogalska, Jean-Philippe Gagné, Olivia Gavard, Arun Prasath Damodaran, 2020, 10.1101/2020.11.04.368498
  • Liver poly(ADP-ribose)polymerase is resistant to cleavage by caspases., , Biochemical and biophysical research communications, 1999, 10.1006/bbrc.1999.0313
  • Proteolytic cleavage of poly(ADP-ribose) polymerase in human leukemia cells treated with etoposide and other cytotoxic agents, , ADP-ribosylation Reactions, 1992
  • Transcriptional regulation of the rat poly(ADP-ribose) polymerase gene by Sp1., , European journal of biochemistry, 1997, 10.1111/j.1432-1033.1997.0342a.x
  • Rapid assay of poly(ADP-ribose) glycohydrolase., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1987, 10.1139/o87-088
  • Determination of Poly(ADP-Ribose) polymerase activation and cleavage during cell death, , Cell death. The role of PARP, 2000
  • The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice., , Nature cell biology, 2015, 10.1038/ncb3259
  • Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair., , Proceedings of the National Academy of Sciences of the United States of America, 2021, 10.1073/pnas.2019408118
  • Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions., , Canadian journal of gastroenterology & hepatology, 2018, 10.1155/2018/8096314
  • Structural analysis of the putative regulatory region of the rat gene encoding poly(ADP-ribose) polymerase., , FEBS letters, 1992, 10.1016/0014-5793(92)80457-r
  • Chromosomal protein poly(ADP-ribosyl)ation in pancreatic nucleosomes., , Canadian journal of biochemistry, 1982, 10.1139/o82-036
  • Poly(ADP-ribosyl)ation reactions and modulation of chromatin structure, , DNA repair mechanisms and their biological implications in mammalian cells, 1990
  • Identification of mitofusin 1 and complement component 1q subcomponent-binding protein as mitochondrial targets in systemic lupus erythematosus., , Arthritis & rheumatology (Hoboken, N.J.), 2022, 10.1002/art.42082
  • Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 10.1523/JNEUROSCI.3461-04.2004
  • DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer., , Biomolecules, 2015, 10.3390/biom5043204
  • Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes., , Nucleic acids research, 2008, 10.1093/nar/gkn771
  • Poly(ADP-ribose) polymerase can bind melphalan damaged DNA., , Cancer research, 1993
  • Poly(ADP‐ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation, Shaida A. Andrabi, Ted M. Dawson, Valina L. Dawson, Peter H. King, Guy G. Poirier, Junaid Khan, Jean‐Philippe Gagné, Jun Hee Lee, M. Iqbal Hossain, The FASEB Journal, 2024, 10.1096/fj.202302559R
  • In-situ analysis of cellular poly(ADP-ribose) production in scrapie-infected mouse neuroblastoma cells., , The Histochemical journal, 2002, 10.1023/a:1023398130945
  • Drosophila Tubulin-Specific Chaperone E Recruits Tubulin around Chromatin to Promote Mitotic Spindle Assembly., , Current biology : CB, 2021, 10.1016/j.cub.2020.11.009
  • Polypeptide receptor mechanisms in anterior pituitary gland, , Anatomical neuroendocrinology: based on the International Conference on Neurobiology of CNS-Hormone Interactions, Chapel Hill, N. C., May 14-16, 1974, 1975
  • Structural biology. PARP-1 activation--bringing the pieces together., , Science (New York, N.Y.), 2012, 10.1126/science.1221870
  • Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor., , Science (New York, N.Y.), 2002, 10.1126/science.1072221
  • Hyperthermia and poly(ADP-ribose) metabolism, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • Delayed weaning and denial of solid food nibbling upon pancreatic acinar cell responsiveness to urecholine in neonatal rats., , Digestion, 1978, 10.1159/000198188
  • The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis., , The Journal of biological chemistry, 1995, 10.1074/jbc.270.28.16526
  • Separation of poly(ADP-ribosylated) nuclear proteins by polyacrylamide gel electrophoresis at acidic pH and low temperature., , Analytical biochemistry, 1981, 10.1016/0003-2697(81)90489-9
  • An approach to assessing peptide mass spectral quality without prior information, , International Journal of Functional Informatics and Personalised Medicine IJFIPM, 2008
  • Effects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains., , Brain research. Molecular brain research, 2000, 10.1016/s0169-328x(00)00122-4
  • Affinity-based assays for the identification and quantitative evaluation of noncovalent poly(ADP-ribose)-binding proteins., , Methods in molecular biology (Clifton, N.J.), 2011, 10.1007/978-1-61779-270-0_7
  • Erasable blot of poly(ADP-ribose) polymerase., , Analytical biochemistry, 1994, 10.1006/abio.1994.1212
  • Alteration of poly(ADP-ribose) glycohydrolase nucleocytoplasmic shuttling characteristics upon cleavage by apoptotic proteases., , Biology of the cell, 2003, 10.1016/j.biolcel.2003.10.003
  • Equilibrium model in an in vitro poly(ADP-ribose) turnover system., , Biochimica et biophysica acta, 1995, 10.1016/0167-4781(95)00143-5
  • Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro., , Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, 10.1158/1078-0432.CCR-11-2890
  • Muscarinic receptors of the pancreas: a correlation between displacement of (3 H)-quinuclidinyl benzilate binding and amylase secretion., , Pharmacology, 1979, 10.1159/000137262
  • Poly(adenosine diphosphoribose) polymerase activity and adenosine diphosphate ribosylation of proteins during pancreatic degeneration and regeneration., , Cancer research, 1981
  • Maturation of muscarinic agonist receptors in rat developing pancreas and its relation to maximal enzyme secretion., , Life sciences, 1981, 10.1016/0024-3205(81)90537-3
  • Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis., , The Journal of biological chemistry, 1999, 10.1074/jbc.274.7.4335
  • ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase., , The EMBO journal, 1997, 10.1093/emboj/16.19.6018
  • Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme., , Molecular cell, 2007, 10.1016/j.molcel.2007.06.027
  • Hypophysiotropic hormones, cyclic AMP and adenohypophyseal protein synthesis and release, , Hormones and brain function. [Proceedings of the second congress of the International Society of Psychoneuroendocrinology held in Budapest (Hungary) from July 1 to 3, 1971] Edited by K. Lissâak, 1973
  • Niacin deficiency increases the sensitivity of rats to the short and long term effects of ethylnitrosourea treatment., , Molecular and cellular biochemistry, 1999
  • Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms., , The American journal of pathology, 1997
  • Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum., , Nucleic acids research, 2015, 10.1093/nar/gkv118
  • Dynamic relocation of poly(ADP-ribose) glycohydrolase isoforms during radiation-induced DNA damage., , Biochimica et biophysica acta, 2006, 10.1016/j.bbamcr.2005.11.015
  • Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo., , Analytical biochemistry, 1995, 10.1006/abio.1995.1245
  • Inhibition of ICE-related proteases (caspases) and nuclear apoptosis by phenylarsine oxide., , Experimental cell research, 1997, 10.1006/excr.1996.3459
  • The effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin. A role of poly(ADP-ribosyl)ation on core nucleosome structure., , The Journal of biological chemistry, 1989
  • Properties of poly(ADP-ribose) synthetase from rat pancreas and poly(ADP-ribosylation) of basic nuclear proteins., , Canadian journal of biochemistry, 1978, 10.1139/o78-119
  • DNA replication and poly(ADP-ribosyl)ation of chromatin., , Cytobios, 1989
  • The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy., , Journal of cell science, 2013, 10.1242/jcs.114595
  • Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure., , Proceedings of the National Academy of Sciences of the United States of America, 1982, 10.1073/pnas.79.11.3423
  • Stimulation of poly(ADP-ribose) synthesis by free radicals in C3H10T1/2 cells: relationship with NAD metabolism and DNA breakage., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1990, 10.1139/o90-085
  • Transcription. Gene expression needs a break to unwind before carrying on., , Science (New York, N.Y.), 2006, 10.1126/science.1129808
  • Reconstitution of an in vitro poly(ADP)-ribose turnover system, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • A convenient method for the ATPase assay., , Analytical biochemistry, 1978, 10.1016/0003-2697(78)90277-4
  • Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis., , Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1405158111
  • Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry., , Proteome science, 2010, 10.1186/1477-5956-8-22
  • Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase., , Cell, 1995, 10.1016/0092-8674(95)90541-3
  • Effect of hyperthermia on poly(adenosine diphosphate-ribose) glycohydrolase., , Cancer research, 1988
  • Cloning of rodent cDNA coding the poly(ADP-ribose) polymerase catalytic domain and analysis of mRNA levels during the cell cycle., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1989, 10.1139/o89-097
  • Assessment of PARP-1 Distribution in Tissues of Cynomolgus Monkeys., , The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2020, 10.1369/0022155420926022
  • Rapid detection of poly(ADP-ribose) polymerase by enzyme-linked immunosorbent assay during its purification and improvement of its purification., , Molecular and cellular biochemistry, 1998, 10.1023/a:1006861015142
  • Proteomic characterization of mouse cytosolic and membrane prostate fractions: high levels of free SUMO peptides are androgen-regulated., , Journal of proteome research, 2008, 10.1021/pr8002497
  • Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage., , Biochemistry, 1994, 10.1021/bi00189a012
  • Poly(ADP-ribose)polymerase: a novel finger protein., , Nucleic acids research, 1989, 10.1093/nar/17.12.4689
  • ADP-ribosylation Reactions, , 1992
  • Poly(ADP-ribosylation) and apoptosis., , Molecular and cellular biochemistry, 1999, 10.1023/a:1006962716377
  • CrmA/SPI-2 inhibition of an endogenous ICE-related protease responsible for lamin A cleavage and apoptotic nuclear fragmentation., , The Journal of biological chemistry, 1996, 10.1074/jbc.271.51.32487
  • Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells., , Journal of virology, 1996, 10.1128/JVI.70.4.2215-2220.1996
  • Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7., , The Journal of biological chemistry, 1999, 10.1074/jbc.274.40.28379
  • Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes., , Journal of virology, 2008, 10.1128/JVI.01405-07
  • Proteolytic degradation of poly(ADP-ribose) polymerase by contaminating proteases in commercial preparations of DNAse I, , ADP-ribosylation Reactions, 1992
  • Purification of the death substrate poly(ADP-ribose) polymerase., , Analytical biochemistry, 1997, 10.1006/abio.1997.2153
  • The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives., , Current opinion in cell biology, 2006, 10.1016/j.ceb.2006.02.013
  • Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)., , Science signaling, 2011, 10.1126/scisignal.2000902
  • A novel approach to denoising ion trap tandem mass spectra., , Proteome science, 2009, 10.1186/1477-5956-7-9
  • Alteration in methyl-methanesulfonate-induced poly(ADP-ribosyl)ation by 2-butoxyethanol in Syrian hamster embryo cells., , Carcinogenesis, 1997, 10.1093/carcin/18.12.2333
  • Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities., , Oncotarget, 2016, 10.18632/oncotarget.13341
  • Characterization and purification of a calcium-sensitive ATP diphosphohydrolase from pig pancreas., , The Journal of biological chemistry, 1980
  • Drosophila dTBCE recruits tubulin around chromatin to promote mitotic spindle assembly, Régis Giet, Christelle Benaud, Laurent Richard-Parpaillon, Romain Gibeaux, Denis Chrétien, Guy G. Poirier, Jean-Philippe Gagné, Aude Pascal, Emmanuel Gallaud, Mathieu Métivier, 2020, 10.1101/2020.01.21.912428
  • Visualization of poly(ADP-ribose) synthetase associated with polynucleosomes by immunoelectron microscopy., , Biochimica et biophysica acta, 1986, 10.1016/0167-4889(86)90239-9
  • Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks., , Radiation research, 1997
  • Proteolysis of poly(ADP-ribose) polymerase by caspase 3: kinetics of cleavage of mono(ADP-ribosyl)ated and DNA-bound substrates., , Radiation research, 1998
  • PARP1 parylation promotes silent locus transmission in the nucleolus: the suspicion confirmed., , Molecular cell, 2012, 10.1016/j.molcel.2012.03.012
  • Niacin deficiency in rats increases the severity of ethylnitrosourea-induced anemia and leukopenia., , The Journal of nutrition, 2000, 10.1093/jn/130.5.1102
  • Overexpression of bcl-2 or bcl-XL fails to inhibit apoptosis mediated by a novel retinoid., , Oncology research, 1998
  • Ethoxyresorufin O-deethylase (EROD) activity in placental tissue from Inuit women exposed to organochlorines through the arctic food chain, , Organohalogen Compounds, 1996
  • Parallel maturation of the pancreatic secretory response to cholinergic stimulation and the muscarinic receptor population., , British journal of pharmacology, 1981, 10.1111/j.1476-5381.1981.tb10428.x
  • Muscarinic receptor of rat pancreatic acini: [3H]QNB binding and amylase., , European journal of pharmacology, 1981, 10.1016/0014-2999(81)90508-2
  • Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase., , The Journal of biological chemistry, 2002, 10.1074/jbc.C200366200
  • The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase, Anthony R. Fehr, Scott Lovell, Guy G. Poirier, Erik D. Holmstrom, David K. Johnson, Kevin P. Battaile, Louis Nonfoux, Philip Gao, Peter McDonald, Jean-Philippe Gagné, Anuradha Roy, Maithri M. Kashipathy, Yousef M.O. Alhammad, 2020, 10.1101/2020.05.11.089375
  • Adenosine diphosphoribosylation of certain basic chromosomal proteins in isolated trout testis nuclei., , European journal of biochemistry, 1977, 10.1111/j.1432-1033.1977.tb11635.x
  • Poly(ADP-ribosyl)ation of chromatin: kinetics of relaxation and its effect on chromatin solubility., , Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 1985, 10.1139/o85-096
  • Diethylnitrosamine administration in vivo increases hepatic poly(ADP-ribose) levels in rats: results of a modified technique for poly(ADP-ribose) measurement., , Carcinogenesis, 1993, 10.1093/carcin/14.12.2513
  • Nuclear factor 1 interferes with Sp1 binding through a composite element on the rat poly(ADP-ribose) polymerase promoter to modulate its activity in vitro., , The Journal of biological chemistry, 2001, 10.1074/jbc.M010360200
  • An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain., , Development (Cambridge, England), 2010, 10.1242/dev.051052
  • Distribution of muscarinic receptors in the digestive tract organs., , Pharmacology, 1981, 10.1159/000137489
  • Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks., , Trends in biochemical sciences, 1995, 10.1016/s0968-0004(00)89089-1
  • ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion., , Cell reports, 2014, 10.1016/j.celrep.2014.08.036
  • Modulation of rat pancreatic muscarinic cholinergic receptors by caerulein., , Biochemical pharmacology, 1985, 10.1016/0006-2952(85)90609-4
  • Differential proteomic screen to evidence proteins ubiquitinated upon mitotic exit in cell-free extract of Xenopus laevis embryos., , Journal of proteome research, 2008, 10.1021/pr800250x
  • Expression of poly(ADP-ribose) polymerase in differentiating HL-60 cells, , ADP-ribosylation Reactions, 1992
  • Effect of potato suberin on Streptomyces scabies proteome., , Molecular plant pathology, 2008, 10.1111/j.1364-3703.2008.00493.x
  • Analysis of ADP-ribose polymer sizes in intact cells., , Molecular and cellular biochemistry, 2001, 10.1023/a:1011910329010
  • A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors., , Clinical cancer research : an official journal of the American Association for Cancer Research, 2018, 10.1158/1078-0432.CCR-17-1590
  • Regulation of poly(ADP-ribose) metabolism by poly(ADP-ribose) glycohydrolase: where and when?, , Cellular and molecular life sciences : CMLS, 2005, 10.1007/s00018-004-4505-1
  • Nucleosomal poly(ADP-ribose) polymerase: properties and relaxation of the chromatin structure., , Princess Takamatsu symposia., 1983
  • Identification of sequence-specific DNA-binding proteins by southwestern blotting., , Methods in molecular biology (Clifton, N.J.), 2001, 10.1385/1-59259-208-2:255
  • Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks., , Molecular cell, 2018, 10.1016/j.molcel.2018.05.013
  • Glycol ethers induce death and necrosis in human leukemia cells., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
  • Expression in E. coli of the catalytic domain of rat poly(ADP-ribose)polymerase., , FEBS letters, 1990, 10.1016/0014-5793(90)80770-j
  • High-performance electrophoresis chromatography., , Methods in molecular biology (Clifton, N.J.), 1996, 10.1385/0-89603-336-8:371
  • Rapid removal of nonspecific background in silver-stained polyacrylamide gel., , Analytical biochemistry, 1995, 10.1006/abio.1995.9947
  • Bioinformatics standards for mass spectrometry, , Current Proteomics: the journal for current and in-depth reviews on proteomics, 2006
  • The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver., , The Journal of biological chemistry, 2010, 10.1074/jbc.M109.073908
  • Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain., , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.0597
  • RT-PSM, a real-time program for peptide-spectrum matching with statistical significance., , Rapid communications in mass spectrometry : RCM, 2006, 10.1002/rcm.2435
  • Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation., , The Journal of biological chemistry, 1986
  • Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4., , Virology, 2007, 10.1016/j.virol.2006.08.035
  • ADP-ribosylation of pancreatic histone H1 and of other histones., , Canadian journal of biochemistry, 1980, 10.1139/o80-069
  • Association of poly(ADP-ribose) polymerase with nuclear subfractions catalyzed with sodium tetrathionate and hydrogene peroxide crosslinks., , Molecular and cellular biochemistry, 1996, 10.1007/BF00420918
  • Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death., , Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0606528103
  • Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption., , Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2000, 10.1016/s0278-6915(00)00089-2
  • Retinoid induced apoptosis in leukemia cells through a retinoic acid nuclear receptor-independent pathway., , Blood, 1997
  • Purification of plasma membranes from rat pancreas: a rapid method., , Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1977, 10.3181/00379727-155-39799
  • Extrusion of earthworm coelomocytes: comparison of the cell populations recovered from the species Lumbricus terrestris, Eisenia fetida and Octolasion tyrtaeum., , Laboratory animals, 1997, 10.1258/002367797780596068
  • Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE., , Nature, 1994, 10.1038/371346a0
  • Cell cycle regulation of poly(ADP-ribose) synthetase in FR3T3 cells., , Biochimica et biophysica acta, 1988, 10.1016/0167-4889(88)90018-3
  • Adenosine diphosphate ribosylation of proteins in rat pancreas [proceedings]., , Biochemical Society transactions, 1980, 10.1042/bst0080192
  • Characterization of anti-peptide antibodies directed towards the automodification domain and apoptotic fragment of poly (ADP-ribose) polymerase., , Biochimica et biophysica acta, 1997, 10.1016/s0304-4165(96)00077-3
  • Hyper(ADP-ribosyl)ation of histone H1., , Canadian journal of biochemistry, 1982, 10.1139/o82-139
  • Comparative study of DNA adducts levels in white sucker fish (Catostomus commersoni) from the basin of the St. Lawrence River (Canada)., , Molecular and cellular biochemistry, 1995, 10.1007/BF00928150
  • Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors., , Experimental cell research, 1996, 10.1006/excr.1996.0259
  • Germline mutations in BAP1 impair its function in DNA double-strand break repair., , Cancer research, 2014, 10.1158/0008-5472.CAN-13-3109
  • Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec., , Environmental health perspectives, 2002, 10.1289/ehp.02110607
  • Influence of duration of focal cerebral ischemia and neuronal nitric oxide synthase on translocation of apoptosis-inducing factor to the nucleus., , Neuroscience, 2007, 10.1016/j.neuroscience.2006.08.065
  • Poly(ADP-ribosyl)ated chromatin domains: access granted., , Journal of cell science, 2004, 10.1242/jcs.01080
  • Proteomic investigation of phosphorylation sites in poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase., , Journal of proteome research, 2009, 10.1021/pr800810n
  • Bcl-2 acts upstream of the PARP protease and prevents its activation., , Cell death and differentiation, 1997, 10.1038/sj.cdd.4400200
  • Poly(ADP-ribose) catabolism in mammalian cells., , Molecular and cellular biochemistry, 1994, 10.1007/BF00928442
  • Non-histone chromosomal protein acceptors for poly(ADP)-ribose in phorbol-12-myristate-13-acetate treated mouse embryo fibroblasts (C3H10T1/2)., , Carcinogenesis, 1985, 10.1093/carcin/6.10.1489
  • Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis., , Journal of cell science, 2001
  • Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis., , The Journal of biological chemistry, 1997, 10.1074/jbc.272.30.18530
  • Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis., , European journal of biochemistry, 1998, 10.1046/j.1432-1327.1998.2510295.x
  • Poly(ADP-ribose) (PAR) polymer is a death signal., , Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0606526103
  • Reconstitution of an in vitro poly(ADP-ribose) turnover system., , Biochimica et biophysica acta, 1990, 10.1016/0167-4781(90)90083-e
  • Human Proteinpedia enables sharing of human protein data., , Nature biotechnology, 2008, 10.1038/nbt0208-164
  • One-step protein purification using micropreparative electrophoresis fully compatible with protein microsequencing., , Analytical biochemistry, 1994, 10.1006/abio.1994.1437
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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Louis Marie Paul Michel Nonfoux - Doctorat - En cours
  • Olivia Gavard - Doctorat - 2016/01
  • Maria Tedim Ferreira - Doctorat - 2018/09
  • Julia O'Sullivan - Doctorat - 2021/09
*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.