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Jacques Côté

Professeur titulaire

Jacques Côté
jacques.cote.8@ulaval.ca
Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Oncologie
Reproduction, génétique, périnatalité et développement

Domaines et intérêts de recherche du (de la) professeur(e) :

Subcellulaire
  • Acides nucléiques
  • Enzymes et protéines
Cancer
  • Carcinogénèse
  • Division cellulaire
  • Gène suppresseur
  • Génétique du cancer
  • Oncogènes
  • Signalisation cellulaire et cancer
Génomique et protéomique
  • Mécanismes biologiques et biochimiques
  • Protéomique fonctionnelle et structurale
Organisation et fonctions biologiques

Projets de recherche

  • Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines - Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université du Québec à Montréal - UQAM , co-chercheur - 2024-04-01 au 2030-03-31
  • Functional analysis of the NuA4/TIP60 complex in epigenetic mechanisms linked to genome expression and stability - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-10-01 au 2027-09-30
  • Role of MYST-ING acetyltransferase complexes in transcription regulation, cell fate and disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-07-01 au 2027-06-30
  • Functional analysis of the NuA4/TIP60 complex in epigenetic mechanisms linked to genome expression and stability - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-03-01 au 2027-03-31
  • Defining nucleosome features regulating the function of chromatin modifiers and remodelers - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2022-04-01 au 2027-03-31
  • Mécanismes moléculaires orchestrant la transition épithélio-mésenchymateuse - Fonds de recherche du Québec - Nature et technologies - Projet de recherche en équipe, co-chercheur - 2023-04-01 au 2026-03-31
  • Cell Signaling in Cancer (9-10 oct. 2024) - Fondation Gairdner (La), chercheur principal - 2023-11-27 au 2025-04-30
  • Tetrahymena thermophila - un model évolutionnaire divergent pour découvrir de nouveau modes de régulation transcriptionnelle - Conseil de recherches en sciences naturelles et génie Canada, Fonds de recherche du Québec - Nature et technologies - Programme NOVA- FRQNT-CRSNG pour chercheurs et chercheuses en début de carrière (PILOTE), co-chercheur - 2022-03-15 au 2025-03-14
  • Understanding the molecular determinants of high-grade endometrial stromal sarcomas - Société de recherche sur le cancer - Subvention de fonctionnement, chercheur principal - 2022-09-01 au 2024-08-31
  • Plateforme de culture cellulaire pour l'analyse fonctionnelle de modificateurs épigénétiques liés aux maladies humaines - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2022-04-01 au 2023-09-28
  • Gene Application to engage a Model Organism Researcher – ING3 - Instituts de recherche en santé du Canada - Réseau catalyseur de la recherche : maladies rares, chercheur principal - 2021-09-01 au 2022-08-31

Publications

  • A Chromatin Switch for Chromosome Condensation, Côté, J., Bilodeau, S., Developmental Cell, 2012, 10.1016/j.devcel.2012.11.016
  • Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription, Côté, J., Stillman, D.J., Lane, W.S., Savard, J., Allard, S., Héliot, L., Zhang, Y., Boudreault, A.A., Nourani, A., Galarneau, L., Molecular Cell, 2000, 10.1016/S1097-2765(00)80258-0
  • Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes, Asturias, F.J., Côté, J., Tan, S., Fried, M.G., Workman, J.L., Cai, G., Allard, S., Cramet, M., Utley, R.T., Huang, J., Selleck, W., Sapountzi, V., Carrozza, M.J., Monnet-Saksouk, J., Chaban, Y., Chittuluru, J.R., Nature Structural and Molecular Biology, 2011, 10.1038/nsmb.2128
  • Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection, Jacques Cote, Structure, 2022, 10.1016/j.str.2022.05.020
  • HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail, Côté, J., Kutateladze, T.G., Gozani, O., Yang, X.-J., Côté, V., Landry, A.-J., Ullah, M., Paquet, E., Cayrou, C., Doyon, Y., Hung, T., Champagne, K.S., Avvakumov, N., Saksouk, N., Molecular Cell, 2009, 10.1016/j.molcel.2009.01.007
  • Stimulation of transcription factor binding and histone displacement by nucleosome assembly protein 1 and nucleoplasmin requires disruption of the histone octamer, Workman, J.L., Côté, J., Owen-Hughes, T.A., Walter, P.P., Molecular and Cellular Biology, 1995, 10.1128/MCB.15.11.6178
  • Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9, Kron, S.J., Côté, J., Sha, F., Allard, S., Javaheri, A., Wysocki, R., Molecular and Cellular Biology, 2005, 10.1128/MCB.25.19.8430-8443.2005
  • [7] Experimental analysis of transcription factor-nucleosome interactions, Workman, J.L., Walter, P., Côté, J., Adams, C.C., Vettese-Dadey, M., Methods in Molecular Genetics, 1995, 10.1016/S1067-2389(06)80010-5
  • Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping, Kron, S.J., Côté, J., Altaf, M., Nnakwe, C.C., DNA Repair, 2009, 10.1016/j.dnarep.2009.09.010
  • Regulation of histone and beta A-globin gene expression during differentiation of chicken erythroid cells., Ruiz-Carrillo, A., Renaud, J., Côté, J., Affolter, M., Molecular and Cellular Biology, 1987
  • MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair, Pandita, T.K., Cote, J., Chen, D.J., Porteus, M.H., Pandita, R.K., Bhadra, U., Avvakumov, N., Cayrou, C., Kumar, R., Gupta, A., So, S., Sharma, G.G., Molecular and Cellular Biology, 2010, 10.1128/MCB.01476-09
  • Measurement and Analysis of Lysine Acetylation by KAT Complexes In Vitro and In Vivo., , Methods in molecular biology (Clifton, N.J.), 2019, 10.1007/978-1-4939-9434-2_5
  • Recognition of Histone H3K14 Acylation by MORF., , Structure, 2017, 10.1016/j.str.2017.02.003
  • Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans, Côté, J., Tan, S., Lane, W.S., Selleck, W., Doyon, Y., Molecular and Cellular Biology, 2004, 10.1128/MCB.24.5.1884-1896.2004
  • Signal transducers and activators of transcription-3/Pim1 Axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension, Bonnet, S., Sussman, M.A., Provencher, S., Côté, J., Saksouk, N., Dumas De La Roque, E., Mainguy, V., Meloche, J., Courboulin, A., Paulin, R., Circulation, 2011, 10.1161/CIRCULATIONAHA.110.963314
  • A family of chromatin remodeling factors related to Williams syndrome transcription factor, Shiekhattar, R., Côté, J., Moore, P., Lafleur, D.W., Wang, W., Savard, J., Bochar, D.A., Proceedings of the National Academy of Sciences of the United States of America, 2000, 10.1073/pnas.97.3.1038
  • Epigenetic modifications in double-strand break DNA damage signaling and repair, Côté, J., Kron, S.J., Truman, A.W., Rossetto, D., Clinical Cancer Research, 2010, 10.1158/1078-0432.CCR-10-0513
  • Histone Chaperones: Modulators of Chromatin Marks, Côté, J., Nourani, A., Avvakumov, N., Molecular Cell, 2011, 10.1016/j.molcel.2011.02.013
  • The Candida glabrata Amt1 copper-sensing transcription factor requires Swi/Snf and Gcn5 at a critical step in copper detoxification, Thiele, D.J., Côté, J., Santoro, N., Allard, S., Koch, K.A., Molecular Microbiology, 2001, 10.1046/j.1365-2958.2001.02458.x
  • The diverse functions of histone acetyltransferase complexes, Côté, J., Workman, J.L., Utley, R.T., Carrozza, M.J., Trends in Genetics, 2003, 10.1016/S0168-9525(03)00115-X
  • Eaf1 Links the NuA4 Histone Acetyltransferase Complex to Htz1 Incorporation and Regulation of Purine Biosynthesis, Côté, J., Robert, F., Utley, R. T., Paquet, E., Drouin, S., Altaf, M., Auger, A., Cheng, X., Eukaryot Cell, 2015, 10.1128/EC.00004-15
  • NuA4 and SAGA acetyltransferase complexes cooperate for repair of DNA breaks by homologous recombination, Jacques Côté, Valérie Côté, Xue Cheng, PLOS Genetics, 2021, 10.1371/journal.pgen.1009459
  • NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex, Côté, J., Gaudreau, L., Utley, R.T., Lacoste, N., Bouchard, N., Cramet, M., Piquet, S., Brodeur, J., Monnet-Saksouk, J., Auger, A., Altaf, M., Journal of Biological Chemistry, 2010, 10.1074/jbc.M110.117069
  • Purification and biochemical heterogeneity of the mammalian SWI-SNF complex, Crabtree, G.R., Workman, J.L., Yaniv, M., Goff, S.P., Kalpana, G.V., Muchardt, C., Biggar, S.R., Khavari, P.A., Zhou, S., Xue, Y., Côté, J., Wang, W., EMBO Journal, 1996
  • New Nomenclature for Chromatin-Modifying Enzymes, Zhang, Y., Workman, J., Shilatifard, A., Shiekhattar, R., Shi, Y., Reinberg, D., Pillus, L., Kouzarides, T., Jenuwien, T., Dent, S., Cote, J., Berger, S.L., Allis, C.D., Cell, 2007, 10.1016/j.cell.2007.10.039
  • Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex, , Cell Reports, 2020, 10.1016/j.celrep.2020.03.003
  • Differential remodeling of the HIV-1 nucleosome upon transcription activators and SWI/SNF complex binding, Dimitrov, S., Khochbin, S., Côté, J., Seve, M., Charra, M., Angelov, D., Journal of Molecular Biology, 2000, 10.1006/jmbi.2000.4069
  • Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection, , PNAS, 2018, 10.1073/pnas.1806513115
  • Preparation and Analysis of Native Chromatin-Modifying Complexes, Côté, J., Doyon, Y., Methods in Enzymology, 2016, 10.1016/bs.mie.2016.01.017
  • ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation, Côté, J., Yang, X.-J., Tan, S., Lane, W.S., Selleck, W., Côté, V., Landry, A.-J., Ullah, M., Cayrou, C., Doyon, Y., Molecular Cell, 2006, 10.1016/j.molcel.2005.12.007
  • Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex, Cai, G., Côté, J., Zhang, Z., Ahmad, S., Wang, X., Nature Communications, 2018, 10.1038/s41467-018-03504-5
  • TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes, Brandl, C.J., Cote', J., Allard, S., Genereaux, J., Martens, J.A., Collart, M., Saleh, A., Journal of Molecular Biology, 1998, 10.1006/jmbi.1998.2036
  • Identification and Analysis of Native HAT Complexes, Grant, P.A., Côté, J., Doyon, Y., McMahon, S.J., Methods in Enzymology, 2004, 10.1016/S0076-6879(03)77008-6
  • Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation, Côté, J., Kutateladze, T.G., Yang, X.-J., Richard, D.E., Robitaille, G.A., Cayrou, C., Doyon, Y., Landry, A.-J., Glass, K.C., Paquet, E., Saksouk, N., Lalonde, M.-E., Avvakumov, N., Molecular and Cellular Biology, 2012, 10.1128/MCB.06455-11
  • Regulation of NuA4 histone acetyltransferase activity in transcription and DNA repair by phosphorylation of histone H4, Côté, J., Allard, S., Jobin-Robitaille, O., Lacoste, N., Utley, R.T., Molecular and Cellular Biology, 2005, 10.1128/MCB.25.18.8179-8190.2005
  • (de)MYSTification and INGenuity of tumor suppressors, Côté, J., Avvakumov, N., Saksouk, N., Cellular and Molecular Life Sciences, 2008, 10.1007/s00018-008-7459-x
  • Precise deposition of histone H2A.Z in chromatin for genome expression and maintenance, Côté, J., Billon, P., Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 2012, 10.1016/j.bbagrm.2011.10.004
  • Histone target selection within chromatin: An exemplary case of teamwork, Côté, J., Cheng, X., Lalonde, M.-E., Genes and Development, 2014, 10.1101/gad.236331.113
  • Tandem PHD aingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin, Kutateladze, T.G., Yang, X.-J., Côté, J., Strahl, B.D., Rothbart, S.B., Degerny, C., Lalonde, M.-E., Yan, K., Ali, M., Journal of Molecular Biology, 2012, 10.1016/j.jmb.2012.10.004
  • The highly conserved and multifunctional NuA4 HAT complex, Côté, J., Doyon, Y., Current Opinion in Genetics and Development, 2004, 10.1016/j.gde.2004.02.009
  • The Yeast NuA4 and Drosophila MSL Complexes Contain Homologous Subunits Important for Transcription Regulation, Côté, J., Lucchesi, J.C., Lanell, W.S., Schmidt, P., Allard, S., Nourani, A., Utley, R.T., Eisen, A., Journal of Biological Chemistry, 2001, 10.1074/jbc.M008159200
  • Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation., , Nature communications, 2019, 10.1038/s41467-019-12551-5
  • The immediate-early protein 1 of human herpesvirus 6B interacts with NBS1 and inhibits ATM signaling, Amélie Fradet-Turcotte, Louis Flamand, Jacques Côté, Julien Dessapt, Anahita Lashgari, Maxime Galloy, Annie Gravel, Andréanne Blondeau, Élise G Lavoie, Vincent Tremblay, Élise Biquand, Vanessa Collin, EMBO Reports, 2024, 10.1038/s44319-023-00035-z
  • Site specificity analysis of Piccolo NuA4-mediated acetylation for different histone complexes, Andrews, A. J., Côté, J., Tan, S., Henry, R. A., Kuo, Y. M., Biochem J, 2015, 10.1042/BJ20150654
  • MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain., Tatiana Kutateladze, Akihiko Yokoyama, Jacques Cote, Poirier MG, Yawen Bai, Martha Bulyk, Amelie Fradet-Turcotte, Galloy M, Lachance C, CHRISTOPHER EBMEIER, Chen RW, Yi Zhang, Phanor SK, Bing-Rui Zhou, Cox KL, Jang SM, Akinori Kanai, Brianna Klein, Dustin C. Becht, Nature communications, 2023, 10.1038/s41467-023-36368-5
  • Regulation of transcription by multisubunit complexes that alter nucleosome structure, Workman, J.L., Ikeda, K., Owen-Hughes, T., Côté, J., Eberharter, A., John, S., Grant, P.A., Utley, R.T., Steger, D.J., Cold Spring Harbor Symposia on Quantitative Biology, 1998
  • Novel mechanism of PCNA control through acetylation of its sliding surface, Jacques Côté, Pierre Billon, Molecular & Cellular Oncology, 2017, 10.1080/23723556.2017.1279724
  • Purification of yeast native reagents for the analysis of chromatin function-I: Nucleosomes for reconstitution and manipulation of histone marks, Côté, J., Bhat, W., Lacoste, N., Methods in Molecular Biology, 2017, 10.1007/978-1-4939-6630-1_3
  • Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci, Jacques Cote, Genes & Development, 2022, 10.1101/gad.348982.121
  • The MYST family of histone acetyltransferases and their intimate links to cancer, Côté, J., Avvakumov, N., Oncogene, 2007, 10.1038/sj.onc.1210608
  • Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin, , Structure, 2020, 10.1016/j.str.2019.10.014
  • Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex, Panchenko, M.V., Côté, J., Vaziri, C., Cayrou, C., Saksouk, N., Cohen, H.T., Chitalia, V.C., Ihn, Y.S., Foy, R.L., Journal of Biological Chemistry, 2008, 10.1074/jbc.M801407200
  • Regulating chromatin by histone acetylation, Côté, J., Rossetto, D., Steunou, A.-L., Fundamentals of Chromatin, 2014, 10.1007/978-1-4614-8624-4_4
  • Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation, Kutateladze, T. G., Luger, K., Côté, J., Poirier, M. G., Kurumizaka, H., Yan, K., Machida, S., Hepler, M., Andrews, F. H., Gibson, M. D., Lalonde, M. E., Muthurajan, U. M., Klein, B. J., Nucleic Acids Res, 2016, 10.1093/nar/gkv1321
  • Characterization of multiple interactions between the envelope E protein of SARS-CoV-2 and human BRD4, Tatiana Kutateladze, Jacques Côté, Siddappa N. Byrareddy, Arpan Acharya, Catherine Lachance, Suk Min Jang, Mohamad Zandian, Jacques Cote, STAR Protocols, 2022, 10.1016/j.xpro.2022.101853
  • EP400 Deposits H3.3 into Promoters and Enhancers during Gene Activation, Carey, M. F., Kurdistani, S. K., Côté, J., Huang, C., Jacquet, K., Yen, L., Su, T., Pradhan, S. K., Mol Cell, 2016, 10.1016/j.molcel.2015.10.039
  • The MOZ-BRPF1 acetyltransferase complex in epigenetic crosstalk linked to gene regulation, development, and human diseases., Côté J, Viita T, Frontiers in cell and developmental biology, 2023, 10.3389/fcell.2022.1115903
  • Opposite role of yeast ING family members in p53-dependent transcriptional activation, Côté, J., Grant, P.A., Workman, J.L., Pray-Grant, M.G., Howe, L., Nourani, A., Journal of Biological Chemistry, 2003, 10.1074/jbc.C300036200
  • Molecular Architecture of the Essential Yeast Histone Acetyltransferase Complex NuA4 Redefines Its Multimodularity, Calvin K. Yip, Jacques Côté, Meng-Qiu Dong, James D. Ross, Shan Lu, Anne-Lise Steunou, Udit Dalwadi, Salar Ahmad, Dheva Setiaputra, Molecular and Cellular Biology, 2018, 10.1128/MCB.00570-17
  • Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1, Kutateladze, T.G., Côté, J., Yasui, A., Kulesza, C.A., Nickoloff, J., Nuñez, J.K., Roy, S., Allen, C., Hong, Z., Lalonde, M.-E., Abraham, C.G., Watanabe, R., Avvakumov, N., Musselman, C.A., Nature Structural and Molecular Biology, 2012, 10.1038/nsmb.2435
  • A Scalable Genome-Editing-Based Approach for Mapping Multiprotein Complexes in Human Cells, Doyon, Y., Côté, J., Herst, P., Roques, C., Huard, C. C., Jacquet, K., Loehr, J., Dalvai, M., Cell Rep, 2015, 10.1016/j.celrep.2015.09.009
  • Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex, Peterson, C.L., Workman, J.L., Quinn, J., Côté, J., Science, 1994, 10.1126/science.8016655
  • A new companion of elongating RNA Polymerase II: TINTIN, an independent sub-module of NuA4/TIP60 for nucleosome transactions, Côté, J., Cheng, X., Transcription, 2014, 10.1080/21541264.2014.995571
  • Structure/function analysis of the phosphatidylinositol-3-kinase domain of yeast Tra1, Brandl, C.J., Haniford, D.B., Andrews, B., Côté, J., Guzzo, J., Jobin-Robitaille, O., MacKenzie, K., Hannam, C., Genereaux, J., Hoke, S.M.T., Mutiu, A.I., Genetics, 2007, 10.1534/genetics.107.074476
  • Histone phosphorylation: A chromatin modification involved in diverse nuclear events, Côté, J., Avvakumov, N., Rossetto, D., Epigenetics, 2012, 10.4161/epi.21975
  • Perturbation of nucleosome core structure by the SWI/SNF complex persists after its detachment, enhancing subsequent transcription factor binding, Workman, J.L., Peterson, C.L., Côté, J., Proceedings of the National Academy of Sciences of the United States of America, 1998, 10.1073/pnas.95.9.4947
  • MRG proteins are shared by multiple protein complexes with distinct functions., , Molecular & cellular proteomics : MCP, 2022, 10.1016/j.mcpro.2022.100253
  • Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription, Moss, T., Côté, J., Rothblum, L.I., Savard, J., Hirschler-Laszkiewicz, I., Faubladier, M., Stefanovsky, V.Y., Pelletier, G., Molecular Cell, 2000, 10.1016/S1097-2765(00)00104-0
  • Transcriptional activators direct histone acetyltransferase complexes to nucleosomes, Workman, J.L., John, S., Eberharter, A., Steger, D.J., Côté, J., Grant, P.A., Ikeda, K., Utley, R.T., Nature, 1998, 10.1038/28886
  • Analysis of nucleosome disruption by ATP-driven chromatin remodeling complexes., Workman, J.L., Havas, K.M., Côté, J., John, S., West, J.M., Steger, D.J., Utley, R.T., Owen-Hughes, T., Methods in molecular biology (Clifton, N.J.), 1999
  • Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes, Kutateladze, T.G., Yang, X.-J., Côté, J., Lalonde, M.-E., Klein, B.J., Epigenetics, 2014, 10.4161/epi.26792
  • DNA damage-induced phosphorylation of histone H2A at serine 15 is linked to DNA end resection. , , Molecular and cellular biology, 2021, 10.1128/mcb.00056-21
  • NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p, Côté, J., Workman, J.L., Pillus, L., Brandl, C.J., Grant, P., Clarke, A., Savard, J., Utley, R.T., Allard, S., EMBO Journal, 1999, 10.1093/emboj/18.18.5108
  • Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures, , Mol Cell, 2018, 10.1016/j.molcel.2018.08.020
  • The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation, Côté, J., Durocher, D., Doyon, Y., Legube, G., Pandita, T.K., Gingras, A.-C., Herst, P., Paquet, E., Pandita, R.K., Roques, C., Lambert, J.-P., Avvakumov, N., Fradet-Turcotte, A., Jacquet, K., Molecular Cell, 2016, 10.1016/j.molcel.2016.03.031
  • Dynamics of chromatin during the repair of DNA double-strand breaks, Côté, J., Downs, J.A., Cell Cycle, 2005, 10.4161/cc.4.10.2108
  • A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans, Michael Kobor, Jacques Cote, Calvin Yip, Nevan Krogan, Frank Holstege, Groot Koerkamp MJA, Joris Benschop, Nikita Avvakumov, Dheva Setiaputra, Nancy Lévesque, Hilary Brewis, Maria Aristizabal, Alyssa C Kirlin, Phoebe Y.T. Lu, Genetics, 2022, 10.1093/genetics/iyac136
  • A novel H2A/H4 nucleosomal histone acetyltransferase in Tetrahymena thermophila, Allis, C.D., Workman, J.L., Côté, J., Cook, R.G., Mizzen, C.A., Brownell, J.E., Steger, D.J., Ohba, R., Molecular and Cellular Biology, 1999
  • Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex, Côté, J., Lane, W.S., Allard, S., Utley, R.T., Doyon, Y., Nourani, A., Molecular and Cellular Biology, 2001, 10.1128/MCB.21.22.7629-7640.2001
  • Eaf1 Is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants, Côté, J., Allard, S., Cronier, D., Utley, R.T., Doyon, Y., Nourani, A., Altaf, M., Galarneau, L., Auger, A., Molecular and Cellular Biology, 2008, 10.1128/MCB.01755-07
  • MChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases, Baetz, K., Figeys, D.A., Côté, J., Basu, A., Ning, Z., Zhou, H., Lambert, J.-P., Hamza, A., Steunou, A.-L., Pourhanifeh-Lemeri, R., Cotrut, M., Huard, S., Mitchell, L., Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1218515110
  • The SWI/SNF complex creates loop domains in DNA and polynucleosome arrays and can disrupt DNA-histone contacts within these domains, Workman, J.L., Peterson, C.L., Landel, C.C., Côté, J., Bazett-Jones, D.P., Molecular and Cellular Biology, 1999, 10.1128/MCB.19.2.1470
  • Role for miR-204 in human pulmonary arterial hypertension, Bonnet, S., Simard, M.J., Côté, J., Provencher, S., Biardel, S., Paquet, E.R., Meloche, J., Perreault, T., Saksouk, N., Giguère, N.J., Paulin, R., Courboulin, A., Journal of Experimental Medicine, 2011, 10.1084/jem.20101812
  • NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis, Jacques Cote, Nature Communications, 2022, 10.1038/s41467-021-27882-5
  • Recruitment of the NuA4 complex poises the PHO5 promoter for chromatin remodeling and activation, Côté, J., Allard, S., Utley, R.T., Nourani, A., EMBO Journal, 2004, 10.1038/sj.emboj.7600230
  • Primers for mitochondrial DNA replication generated by endonuclease G, Ruiz-Carrillo, A., Côté, J., Science, 1993, 10.1126/science.7688144
  • Connection between histone H2A variants and chromatin remodeling complexes, Côté, J., Covic, M., Auger, A., Altaf, M., Biochemistry and Cell Biology, 2009, 10.1139/O08-140
  • The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide, Kutateladze, T.G., Côté, J., Yang, X.-J., Ullah, M., Johnson, K., Peña, P.V., Saksouk, N., Champagne, K.S., Proteins: Structure, Function and Genetics, 2008, 10.1002/prot.22140
  • Purification of yeast native reagents for the analysis of chromatin function-II: Multiprotein complexes and biochemical assays, Côté, J., Bhat, W., Lacoste, N., Methods in Molecular Biology, 2017, 10.1007/978-1-4939-6630-1_4
  • DNA repair: Chromatin remodeling without H2A.Z?, Côté, J., Jacquet, K., Cell Cycle, 2014, 10.4161/cc.28383
  • BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation, Groth, A., Côté, J., Gingras, A. C., Yang, X. J., Paquet, E., Johansen, J. V., Alabert, C., Zhao, X., Lee, S. B., Lambert, J. P., González-Aguilera, C., Lalonde, M. E., Roques, C., Vlassis, A., Feng, Y., EMBO J, 2016, 10.15252/embj.201591293
  • Combined action of histone reader modules regulates NuA4 local acetyltransferase function but not its recruitment on the genome, Côté, J., Kobor, M.S., Robert, F., Krogan, N., Utley, R.T., Paquet, E., Côté, V., Drouin, S., Lacoste, N., Aristizabal, M.J., Rossetto, D., Cramet, M., Steunou, A.-L., Molecular and Cellular Biology, 2016, 10.1128/MCB.00112-16
  • The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres, Cairns, B.R., Côté, J., Tempst, P., Erdjument-Bromage, H., Utley, R., Roberts, D.N., Richardson, D.O., Zhang, H., Molecular and Cellular Biology, 2004, 10.1128/MCB.24.21.9424-9436.2004
  • The epigenetic code of histones | Le code épigénétique des histones, Côté, J., Lacoste, N., Medecine/Sciences, 2003, 10.1051/medsci/20031910955
  • Structural and biophysical characterization of the nucleosome-binding PZP domain., , STAR protocols, 2021, 10.1016/j.xpro.2021.100479
  • Rap1 regulates TIP60 function during fate transition between two-cell-like and pluripotent states., , Genes & development, 2022, 10.1101/gad.349039.121
  • The Saccharomyces cerevisiae Piccolo NuA4 histone acetyltransferase complex requires the enhancer of polycomb A domain and chromodomain to acetylate nucleosomes, Tan, S., Côté, J., Sermwittayawong, D., Fortin, I., Selleck, W., Molecular and Cellular Biology, 2005, 10.1128/MCB.25.13.5535-5542.2005
  • Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase, Tej K. Pandita, Clayton R. Hunt, Biana Godin, Jacques Cote, Sharmistha Chakraborty, Puja Gaur Khaitan, Nobuko T. Horikoshi, Shashank Hambarde, Vijaya K. Charaka, Raj K. Pandita, Fransisca Leonard, Dharmendra Sharma, Nobuo Horikoshi, Communications Biology, 2019, 10.1038/s42003-019-0498-z
  • Histone H3 tail clipping regulates gene expression, Kouzarides, T., Cote, J., Saksouk, N., Bartke, T., Nelson, C., Kirmizis, A., Santos-Rosa, H., Nature Structural and Molecular Biology, 2009, 10.1038/nsmb.1534
  • SWI/SNF stimulates the formation of disparate activator-nucleosome complexes but is partially redundant with cooperative binding, Workman, J.L., Owen-Hughes, T., Côté, J., Utley, R.T., Journal of Biological Chemistry, 1997, 10.1074/jbc.272.19.12642
  • Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes, Jacques Cote, Cell Reports, 2022, 10.1016/j.celrep.2022.110947
  • Mechanisms and consequences of transcription factor binding to nucleosomes, , The Nucleus, 1995
  • Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity, Côté, J., Kutateladze, T.G., Yang, X.-J., Tan, S., Klein, B.J., Tong, Q., Yan, K., Holliday, M., Paquet, E., Saksouk, N., Joncas, F.-H., Glass, K.C., Avvakumov, N., Lalonde, M.-E., Genes and Development, 2013, 10.1101/gad.223396.113
  • In vitro analysis of transcription factor binding to nucleosomes and nucleosome disruption/displacement, Workman, J.L., Adams, C.C., Côté, J., Juan, L.-J., Owen-Hughes, T.A., Utley, R.T., Methods in Enzymology, 1996, 10.1016/S0076-6879(96)74024-7
  • Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase, Côté, J., Poirier, G.G., Hunter, J.M., Utley, R.T., Lacoste, N., Journal of Biological Chemistry, 2002, 10.1074/jbc.C200366200
  • Chromatin remodeling and the maintenance of genome integrity, Côté, J., Masson, J.-Y., Allard, S., Biochimica et Biophysica Acta - Gene Structure and Expression, 2004, 10.1016/j.bbaexp.2003.10.016
  • NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities, Wang, W., Côté, J., Young, M.K., Moreno, G.T., Wong, J., Xue, Y., Molecular Cell, 1998, 10.1016/S1097-2765(00)80299-3
  • Persistent site-specific remodeling of a nucleosome array by transient action of the SWI/SNF complex, Workman, J.L., Peterson, C.L., Côté, J., Utley, R.T., Owen-Hughes, T., Science, 1996, 10.1126/science.273.5274.513
  • De Novo KAT5 Variants Cause a Syndrome with Recognizable Facial Dysmorphisms, Cerebellar Atrophy, Sleep Disturbance, and Epilepsy, , The American Journal of Human Genetics, 2020, 10.1016/j.ajhg.2020.08.002
  • Interplay of Chromatin Modifiers on a Short Basic Patch of Histone H4 Tail Defines the Boundary of Telomeric Heterochromatin, Côté, J., Briggs, S.D., Tan, S., Lacoste, N., Utley, R.T., Altaf, M., Molecular Cell, 2007, 10.1016/j.molcel.2007.12.002
  • A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16, Lucchesi, J.C., Côté, J., Lane, W.S., Huang, R., Cayrou, C., Smith, E.R., Molecular and Cellular Biology, 2005, 10.1128/MCB.25.21.9175-9188.2005
  • The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3/H4 substrate., , J Biol Chem, 2018, 10.1074/jbc.RA117.000677
  • New insights into the DNA repair pathway choice with NuA4/TIP60., , DNA repair, 2022, 10.1016/j.dnarep.2022.103315
  • The Tumor Suppressor PALB2: Inside Out, Masson, J.-Y., Simard, J., Côté, J., Caron, M.-C., Margaillan, G., Rodrigue, A., Brahiti, N., Gao, Y., Lashgari, A., Guitton-Sert, L., Sesma-Sanz, L., Ducy, M., Trends in Biochemical Sciences, 2019, 10.1016/j.tibs.2018.10.008
  • Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling, Côté, J., Kobor, M. S., Nourani, A., Piquet, S., Monnet-Saksouk, J., Côté, V., Schulze, J. M., Lacoste, N., Steunou, A. L., Wang, A. Y., Cramet, M., Rossetto, D., EMBO J, 2014, 10.15252/embj.201386433
  • Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an ada complex and the saga (spt/ada) complex, Workman, J.L., Berger, S.L., Winston, F., Allis, C.D., Owen-Hughes, T., Ohba, R., Candau, R., Brownell, J.E., Roberts, S.M., Côté, J., Duggan, L., Grant, P.A., Genes and Development, 1997, 10.1101/gad.11.13.1640
  • Functions of MYST family histone acetyltransferases and their link to disease, Côté, J., Avvakumov, N., Sub-Cellular Biochemistry, 2007
  • JAZF1: A metabolic actor subunit of the NuA4/TIP60 chromatin modifying complex., Côté J, Mameri A, Frontiers in cell and developmental biology, 2023, 10.3389/fcell.2023.1134268
  • Approaches to Study Native Chromatin-Modifying Complex Activities and Functions, , Frontiers in Cell and Developmental Biology, 2021, 10.3389/fcell.2021.729338
  • Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination, Côté, J., Couture, J.-F., Sugiyama, T., Verreault, A., Gingras, A.-C., Brunzelle, J.S., Tremblay, V., Chen, Y., Lambert, J.-P., Li, J., Billon, P., Molecular Cell, 2017, 10.1016/j.molcel.2016.10.033
  • The MYST family of histone acetyltransferases, Côté, J., Utley, R.T., Current Topics in Microbiology and Immunology, 2003
  • TINTIN, at the interface of chromatin, transcription elongation, and mRNA processing, Côté, J., Ahmad, S., Bhat, W., RNA Biol, 2015, 10.1080/15476286.2015.1026032
  • Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes, Yang, X.-J., Côté, J., Champagne, N., Goh, S.-L., Doyon, Y., Cayrou, C., Tahmasebi, S., Degerny, C., Wang, K., Song, P.Z., Xiao, L., Pelletier, N., Ullah, M., Molecular and Cellular Biology, 2008, 10.1128/MCB.01297-08
  • Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription, Haico van Attikum, Peter A. van Veelen, Jacques Côté, Fabrizio Martino, Kees Vreeken, Xue Cheng, George M.C. Janssen, Anton J.L. de Groot, Leonie Kollenstart, Journal of Biological Chemistry, 2019, 10.1074/jbc.RA119.010302
  • MYST-family histone acetyltransferases: Beyond chromatin, Côté, J., Sapountzi, V., Cellular and Molecular Life Sciences, 2011, 10.1007/s00018-010-0599-9
  • The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling, Dimitrov, S., Bouvet, P., Khochbin, S., Côté, J., Hans, F., Perche, P.-Y., Molla, A., Angelov, D., Molecular Cell, 2003, 10.1016/S1097-2765(03)00100-X
  • Yeast Enhancer of Polycomb defines global Esa1-dependent acetylation of chromatin, Côté, J., Tan, S., Lane, W.S., Savard, J., Allard, S., Utley, R.T., Lacoste, N., Selleck, W., Cronier, D., Boudreault, A.A., Genes and Development, 2003
  • Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain., , Nucl Acids Res, 2018, 10.1093/nar/gkx1151
  • Cellular machineries for chromosomal DNA repair, Côté, J., Peterson, C.L., Genes and Development, 2004, 10.1101/gad.1182704
  • Recognition of (dG)n.(dC)n sequences by endonuclease G. Characterization of the calf thymus nuclease., Ruiz-Carrillo, A., Renaud, J., Côté, J., Journal of Biological Chemistry, 1989
  • Histone modifications in response to DNA damage, Côté, J., Saksouk, N., Altaf, M., Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2007, 10.1016/j.mrfmmm.2006.09.009
  • Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling, Kron, S.J., Côté, J., Altaf, M., Jobin-Robitaille, O., Wysocki, R., Javaheri, A., Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0511192103
  • Perceiving the epigenetic landscape through histone readers, Kutateladze, T.G., Côté, J., Lalonde, M.-E., Musselman, C.A., Nature Structural and Molecular Biology, 2012, 10.1038/nsmb.2436
  • JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage, Yvan Canitrot, Didier Trouche, Jacques Côté, Jean-Philippe Lambert, Jérémy Loehr, Suk-Min Jang, Jonathan Humbert, Catherine Chailleux, Jérémie Fages, PLOS Genetics, 2020, 10.1371/journal.pgen.1008511
  • ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression, Gozani, O., Chua, K.F., Côté, J., Shi, Y., Kutateladze, T.G., Ayer, D.E., Cairns, B.R., Saha, A., Davrazou, F., Cayrou, C., Lacoste, N., Kaadige, M.R., Lan, F., Peña, P., Carney, D., Hung, T., Michishita, E., Ewalt, M., Walter, K.L., Hong, T., Shi, X., Nature, 2006, 10.1038/nature04835
  • Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation, Didier Trouche, Jacques Côté, Estelle Nicolas, Xue Cheng, Marion Aguirrebengoa, Jonathan Humbert, Assala Lamaa, eLife, 2020, 10.7554/eLife.53375
  • MYST protein acetyltransferase activity requires active site lysine autoacetylation, Marmorstein, R., Côté, J., McMahon, S.B., Sternglanz, R., Berger, S.L., Johnson, F.B., Verreault, A., Thibault, P., Speicher, D.W., Zheng, Y.G., Yang, C., Wu, J., Perry, R., Abshiru, N., Speicher, K., Ding, E.C., Hodawadekar, S., Johnson, J., Srinivasan, M., Dang, W., Mellert, H., Rossetto, D., Yuan, H., EMBO Journal, 2012, 10.1038/emboj.2011.382
  • Antagonistic relationship of NuA4 with the non-homologous end-joining machinery at DNA damage sites, Jacques Côté, Mohammed Altaf, Vasileia Sapountzi, Gaëlle Bourriquen, Xue Cheng, Valérie Côté, Salar Ahmad, PLOS Genetics, 2021, 10.1371/journal.pgen.1009816
  • [6] Basic analysis of transcription factor binding to nucleosomes, Workman, J.L., Utley, R.T., Côté, J., Methods in Molecular Genetics, 1995, 10.1016/S1067-2389(06)80009-9
  • Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites, Côté, J., Jackson, S.P., Kron, S.J., Bouchard, N., Auger, A., Javaheri, A., Jobin-Robitaille, O., Allard, S., Downs, J.A., Molecular Cell, 2004, 10.1016/j.molcel.2004.12.003
  • The deubiquitylase Ubp15 couples transcription to mRNA export, François Robert, Jacques Côté, Célia Jeronimo, Fanny Eyboulet, eLife, 2020, 10.7554/eLife.61264
  • La mystification et l’ingéniosité de suppresseurs de tumeurs dans les fonctions nucléaires, Côté, J., Côté, V., Landry, A.-J., Doyon, Y., Cayrou, C., Medecine/Sciences, 2006, 10.1051/medsci/20062211919
  • Systematic identification of signal integration by protein kinase A, Landry, C. R., Stefan, E., Bisson, N., Côté, J., Dionne, U., Steunou, A. L., Chrétien, A., Gagnon-Arsenault, I., Bachmann, V. A., Schraffl, A., Dubé, A. K., Torres-Quiroz, F., Diss, G., Filteau, M., Proc Natl Acad Sci U S A, 2015, 10.1073/pnas.1409938112

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Emile Clerf - Doctorat - En cours
  • Mathieu Dugas - Maîtrise avec mémoire - En cours
  • Amel Mameri - Doctorat - En cours
  • Golareh Asgaritarghi - Doctorat - En cours
  • Erell Cadoret - Doctorat - En cours
  • Juan Carlos Yustis Rubio - Doctorat - En cours
  • Vasilisa Pozharskaia - Post-doctorat - En cours
  • Ke Xu - Doctorat - En cours
  • Marie-Eve Lalonde - Doctorat - 2014/05
  • Xue Cheng - Maîtrise avec mémoire - 2014/09
  • Pierre Billon - Doctorat - 2015/09
  • Karine Jacquet - Doctorat - 2016/05
  • Ibrahim Alharbi - Doctorat - 2020/01
  • Salar Ahmad - Doctorat - 2021/05
  • Maeva Devoucoux - Doctorat - 2021/09
  • Jonathan Humbert - Doctorat - 2022/09
  • Deepthi Sudarshan - Doctorat - 2024/01

Encadrement d'étudiant(e)s pour les programmes suivants :

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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