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Jacques J. Tremblay

Professeur titulaire

Jacques J. Tremblay
jacques-j.tremblay@fmed.ulaval.ca
Centre de recherche en reproduction, développement et santé intergénérationnelle
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Reproduction, génétique, périnatalité et développement

Domaines et intérêts de recherche du (de la) professeur(e) :

Génétique humaine
  • Expression et régulation génique
  • Gènes
  • Interactions gènes et environnement
  • Micropuces d'ADN et d'ARN
  • Génétique moléculaire
  • Modèle transgénique
  • Génomique
  • Protéines
  • Protéomique
  • Thérapie génique
Santé de la mère, des enfants et des adolescents
  • Anomalies congénitales
  • Développement embryonnaire
Cellulaire
  • Cellule
Subcellulaire
  • Acides nucléiques
  • Enzymes et protéines
Génomique et protéomique
  • Bio-informatique
  • Mécanismes biologiques et biochimiques
Organisation et fonctions biologiques
  • Glandes et tissus
  • Métabolisme
  • Reproduction et croissance
Cancer
  • Cancers hormonaux-dépendants
  • Différenciation cellulaire
Nutrition et métabolisme
  • Hormones et facteurs de croissance
  • Pathologies urogénitales
  • Régulation hormonale
  • Système endocrinien
  • Système génito-urinaire

Projets de recherche

  • Réseau Québécois en Reproduction - Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2024-04-01 au 2030-03-31
  • Defining the role of GATA4 in steroidogenic cells and sex differentiation in males using novel mouse models - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-04-01 au 2028-03-31
  • Probing the origins and crosstalk between the different Leydig cell populations in the mammalian gonad - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2022-04-01 au 2027-03-31
  • Rôle du facteur de transcription GATA4 dans la différenciation sexuelle masculine - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2022-07-01 au 2023-06-30
  • Réseau Québécois en Reproduction (RQR) - Fonds de recherche du Québec - Nature et technologies, Université de Sherbrooke, Université Laval - Fonds internes, Université de Montréal, Université du Québec à Trois-Rivières, Institut national de recherche scientifique (INRS) - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2017-04-01 au 2023-03-31

Publications

  • THE NUCLEAR RECEPTOR COUP-TFII ACTIVATES STAR GENE TRANSCRIPTION IN COOPERATION WITH CAMKI IN LEYDIG CELLS, Tremblay, Jacques J., Brousseau, Catherine, Martin, Luc J., Mendoza, Raifish, Journal of Andrology, 2011
  • Pitx1 in vivo promoter activity and mechanisms of positive autoregulation., Jacques Drouin, Gauthier Y, Christian Lanctôt, Marcil A, Paradis FW, Jacques J. Tremblay, Goodyer CG, Neuroendocrinology, 2003, 10.1159/000072794
  • Transcriptional properties of Ptx1 and Ptx2 isoforms., Jacques Drouin, Goodyer CG, Jacques J. Tremblay, Neuroendocrinology, 2000, 10.1159/000054547
  • A 35-bp Conserved Region Is Crucial for Insl3 Promoter Activity in Mouse MA-10 Leydig Cells, Jacques J. Tremblay, Nicholas M. Robert, Kenley Joule Pierre, Xavier C. Giner, International Journal of Molecular Sciences, 2022, 10.3390/ijms232315060
  • Glucocorticoids antagonize cAMP-induced Star transcription in Leydig cells through the orphan nuclear receptor NR4A1., Jacques J. Tremblay, Luc J. Martin, Journal of molecular endocrinology, 2008, 10.1677/jme-07-0145
  • The orphan nuclear receptor Nur77 is a novel regulator of cAMP-mediated StAR gene expression, Tremblay, JJ, Martin, LJ, Biology of Reproduction, 2004
  • Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A(2)-IIA, Boilard, Eric, Gelb, Michael H., Soulet, Denis, Provost, Patrick, Pouliot, Marc, Lambeau, Gerard, Poubelle, Patrice E., Tremblay, Jacques J., Allaeys, Isabelle, Rousseau, Matthieu, Rollet-Labelle, Emmanuelle, Levesque, Tania, Mendoza-Villarroel, Raifish E., Laffont, Benoit, Cloutier, Nathalie, Belleannee, Clemence, Bollinger, James, Boudreau, Luc H., Duchez, Anne-Claire, Proceedings of the National Academy of Sciences, 2015, 10.1073/PNAS.1507905112
  • The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells., Jacques J. Tremblay, Girard MJ, Robert NM, Pierre KJ, Di-Luoffo M, Reproduction (Cambridge, England), 2022, 10.1530/rep-22-0109
  • The ladybird-like homeobox 2 (Lbx2) gene shows region-specific expression within the mouse epididymis, Tremblay, JJ, Moisan, V, Biology of Reproduction, 2004
  • The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2+/calmodulin-dependent protein kinase I., Jacques J. Tremblay, Brousseau C, Boucher N, Luc J. Martin, Molecular endocrinology (Baltimore, Md.), 2008, 10.1210/me.2007-0370
  • Transcriptional cooperation between NF-kappaB p50 and CCAAT/enhancer binding protein beta regulates Nur77 transcription in Leydig cells., Jacques J. Tremblay, Giner XC, El-Asmar B, Journal of molecular endocrinology, 2009, 10.1677/jme-08-0016
  • Differential Response of Transcription Factors to Activated Kinases in Steroidogenic and Non-Steroidogenic Cells, Jacques J. Tremblay, Kenley Joule Pierre, International Journal of Molecular Sciences, 2022, 10.3390/ijms232113153
  • Antagonistic effects of testosterone and the endocrine disruptor mono-(2-ethylhexyl) phthalate on INSL3 transcription in Leydig cells., Laguë E, Jacques J. Tremblay, Endocrinology, 2008, 10.1210/en.2008-0310
  • Mechanisms of MEHP Inhibitory Action and Analysis of Potential Replacement Plasticizers on Leydig Cell Steroidogenesis, Jacques J. Tremblay, Annick N. Enangue Njembele, International Journal of Molecular Sciences, 2021, 10.3390/ijms222111456
  • The human 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase type 2 promoter is a novel target for the immediate early orphan nuclear receptor Nur77 in steroidogenic cells., Jacques J. Tremblay, Luc J. Martin, Endocrinology, 2005, 10.1210/en.2004-0859
  • Isolation of the rat Nur77 promoter and characterization of its regulatory elements in testicular Leydig cells, Tremblay, JJ, Boucher, N, Biology of Reproduction, 2005
  • The pan-pituitary activator of transcription, Ptx1 (pituitary homeobox 1), acts in synergy with SF-1 and Pit1 and is an upstream regulator of the lim-homeodomain gene Lim3/Lhx3, Drouin, J, Lanctot, C, Tremblay, JJ, Molecular Endocrinology, 1998, 10.1210/ME.12.3.428
  • Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins Syndrome, Drouin, J, Beatty, B, Copeland, N, Gilbert, D, Jenkins, N, Tremblay, JJ, Lanctot, C, Crawford, MJ, Mammalian Genome, 1997, 10.1007/S003359900589
  • Role of nuclear receptors in INSL3 gene transcription in Leydig cells., Robert NM, Jacques J. Tremblay, Annals of the New York Academy of Sciences, 2005, 10.1196/annals.1336.020
  • DOES ENDOCRINE DISRUPTION CAUSE CRYPTORCHIDISM: WHERE DO WE STAND?, Lague, Eric, Tyre, Madeline, Tremblay, Jacques J., Journal of Andrology, 2011
  • IL-6 downregulates transcription of NTPDase2 via specific promoter elements., Dranoff JA, Jean Sévigny, Jacques J. Tremblay, Sheung N, Lavoie EG, Yu J, American journal of physiology. Gastrointestinal and liver physiology, 2008, 10.1152/ajpgi.00208.2007
  • The Transcription Factor MEF2 Is a Novel Regulator of Gsta Gene Class in Mouse MA-10 Leydig Cells, Tremblay, Jacques J., Bergeron, Francis, Brousseau, Catherine, Di-Luoffo, Mickael, Endocrinology, 2015, 10.1210/EN.2015-1500
  • Novel transcriptional cooperation between the orphan nuclear receptor Nur77 and AP-1 family members on the star promoter, Tremblay, JJ, Martin, LJ, Biology of Reproduction, 2005
  • Characterization of the platelet-derived growth factor receptor alpha (PDGF-R alpha) promoter in mouse Leydig cells, Tremblay, Jacques, Dube, Charlotte, Biology of Reproduction, 2007
  • Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA (vol 112, pg E3564, 2015), Boilard, Eric, Gelb, Michael H., Soulet, Denis, Provost, Patrick, Pouliot, Marc, Lambeau, Gerard, Poubelle, Patrice E., Tremblay, Jacques J., Allaeys, Isabelle, Rousseau, Matthieu, Rollet-Labelle, Emmanuelle, Levesque, Tania, Mendoza-Villarroel, Raifish E., Laffont, Benoit, Cloutier, Nathalie, Belleannee, Clemence, Bollinger, James, Naika, Gajendra S., Boudreau, Luc H., Duchez, Anne-Claire, Proceedings of the National Academy of Sciences, 2015, 10.1073/PNAS.1522504112
  • The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells, Tremblay, Jacques J., Brousseau, Catherine, Giner, Xavier C., Camire, Etienne, Di-Luoffo, Mickael, Mendoza-Villarroel, Raifish E., Journal of Molecular Endocrinology, 2014, 10.1530/JME-13-0290
  • A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons, Burbach, JPH, Drouin, J, Wolterink, G, vanderKleij, AAM, Cox, JJ, Tremblay, JJ, Lanctot, C, vanSchaick, HSA, Smidt, MP, Proceedings of the National Academy of Sciences, 1997, 10.1073/PNAS.94.24.13305
  • Protein kinase A-dependent cooperation between GATA and CCAAT/enhancer-binding protein transcription factors regulates steroidogenic acute regulatory protein promoter activity., Viger RS, Hamel F, Jacques J. Tremblay, Endocrinology, 2002, 10.1210/en.2002-220413
  • Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH, Simeone, A, Brulet, P, Drouin, J, Macchia, V, Corte, G, Macchia, PE, Mariano, A, di Carlo, A, Lazzaro, D, Tremblay, JJ, Avantaggiato, V, Tuorto, F, Mazan, S, Acampora, D, Development, 1998, 10.1242/DEV.125.7.1229
  • Estradiol represses insulin-like 3 expression and promoter activity in MA-10 Leydig cells., Jacques J. Tremblay, Laguë E, Toxicology, 2009, 10.1016/j.tox.2009.01.013
  • MEF2 Cooperates With Forskolin/cAMP and GATA4 to Regulate Star Gene Expression in Mouse MA-10 Leydig Cells, Tremblay, Jacques J., Paradis, Elise, Di-Luoffo, Mickael, Daems, Caroline, Endocrinology, 2015, 10.1210/EN.2014-1964
  • Modulation of endogenous GATA-4 activity reveals its dual contribution to Mullerian inhibiting substance gene transcription in sertoli cells, Viger, RS, Robert, NM, Tremblay, JJ, Molecular Endocrinology, 2001, 10.1210/ME.15.9.1636
  • FOXA3 Is Expressed in Postnatal Leydig Cells and Regulates Pdgfra Gene Transcription, Tremblay, Jacques J., Brousseau, Catherine, Bergeron, Francis, Garon, Gabriel, Biology of Reproduction, 2011
  • FOXA3 Is Expressed in Multiple Cell Lineages in the Mouse Testis and Regulates Pdgfra Expression in Leydig Cells, Tremblay, Jacques J., Robert, Nicholas M., Brousseau, Catherine, Bergeron, Francis, Garon, Gabriel, Endocrinology, 2017, 10.1210/EN.2016-1736
  • GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements., Viger RS, Jacques J. Tremblay, Endocrinology, 2001, 10.1210/endo.142.3.7995
  • Transcription Factors as Regulators of Gene Expression During Leydig Cell Differentiation and Function, , The Leydig Cell in Health and Disease, 2007, 10.1007/978-1-59745-453-7_23
  • The transcription factor KLF6 is expressed in somatic cells and in a subpopulation of germ cells during mouse testicular development, Tremblay, Jacques, Tremblay, Maxime, Robert, Nicholas, Biology of Reproduction, 2007, 10.1093/BIOLREPROD/77.S1.224B
  • Comprehensive and Quantitative Analysis of the Changes in Proteomic and Phosphoproteomic Profiles during Stimulation and Repression of Steroidogenesis in MA-10 Leydig Cells, Jacques J. Tremblay, Zoheir B. Demmouche, International Journal of Molecular Sciences, 2022, 10.3390/ijms232112846
  • Mechanism of Action of an Environmentally Relevant Organochlorine Mixture in Repressing Steroid Hormone Biosynthesis in Leydig Cells , Jacques J. Tremblay, Janice Bailey, Zoheir B. Demmouche, annick niquaise enangue njembele, International Journal of Molecular Sciences, 2022, 10.3390/ijms23073997
  • Transcription factor GATA-4 is activated by phosphorylation of serine 261 via the cAMP/protein kinase a signaling pathway in gonadal cells., Viger RS, Jacques J. Tremblay, The Journal of biological chemistry, 2003, 10.1074/jbc.m213149200
  • A Cell-Autonomous Molecular Cascade Initiated by AMP-Activated Protein Kinase Represses Steroidogenesis, Tremblay, Jacques J., Bergeron, Francis, Abdou, Houssein S., Molecular and Cellular Biology, 2014, 10.1128/MCB.00734-14
  • Functional cooperation between GATA factors and cJUN on the star promoter in MA-10 Leydig cells., Jacques J. Tremblay, Viger RS, Bergeron F, Luc J. Martin, Journal of andrology, 2012, 10.2164/jandrol.110.012039
  • Phosphorylation of GATA4 serine 105 but not serine 261 is required for testosterone production in the male mouse, Viger, R. S., Pilon, N., Tremblay, J. J., Brousseau, C., Souchkova, O., Taniguchi, H., Bouchard, M. F., Sab, A. Boulende, Bergeron, F., Andrology, 2019, 10.1111/ANDR.12601
  • Transcription Factors in the Regulation of Leydig Cell Gene Expression and Function., Jacques J. Tremblay, Viger RS, de Mattos K, Frontiers in endocrinology, 2022, 10.3389/fendo.2022.881309
  • Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene Expression., Jacques J. Tremblay, de Mattos K, Viger RS, Frontiers in endocrinology, 2022, 10.3389/fendo.2022.902198
  • Upstream stimulatory factor 1 (USF1) and USF2 are expressed in the mouse testis: Implications for testicular gene expression, Pons, E, Tremblay, JJ, Biology of Reproduction, 2005
  • Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription, Drouin, J, Tremblay, JJ, Molecular and Cellular Biology, 1999, 10.1128/MCB.19.4.2567
  • Role of the GATA family of transcription factors in andrology., Jacques J. Tremblay, Robert NM, Hiroaki Taniguchi, Viger RS, Journal of andrology, 2004, 10.1002/j.1939-4640.2004.tb02813.x
  • A mutated form of steroidogenic factor 1 (SF-1 G35E) that causes sex reversal in humans fails to synergize with transcription factor GATA-4., Viger RS, Jacques J. Tremblay, The Journal of biological chemistry, 2003, 10.1074/jbc.m305485200
  • Transcriptional regulation of INSL3 expression in testicular Leydig cells, Tremblay, JJ, Robert, NM, Biology of Reproduction, 2005
  • What signals testis descent?, Jacques J. Tremblay, Biology of reproduction, 2010, 10.1095/biolreprod.110.087197
  • Nuclear receptor Dax-1 represses the transcriptional cooperation between GATA-4 and SF-1 in Sertoli cells., Viger RS, Tremblay JJ, Jacques J. Tremblay, Biology of reproduction, 2001, 10.1095/biolreprod64.4.1191
  • Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain, Drouin, J, Gauthier, Y, Marcil, A, Tremblay, JJ, The EMBO Journal, 1999, 10.1093/EMBOJ/18.12.3431
  • MEF2 Is Restricted to the Male Gonad and Regulates Expression of the Orphan Nuclear Receptor NR4A1, Tremblay, Jacques J., Brousseau, Catherine, Martin, Luc J., Daems, Caroline, Molecular Endocrinology, 2014, 10.1210/ME.2013-1407
  • A STAR for the ages: a 30-year historical perspective of the role of transcription factors in the regulation of steroidogenic acute regulatory gene expression, Jacques J Tremblay, Marie France Bouchard, Robert S Viger, Journal of Endocrinology, 2024, 10.1530/JOE-24-0087
  • Expression of the ladybird-like homeobox2 (Lbx2) factor during mouse testicular and epididymal development, Tremblay, JJ, Bomgardner, D, Moisan, V, Biology of Reproduction, 2005
  • Nuclear receptors in Leydig cell gene expression and function., Jacques J. Tremblay, Luc J. Martin, Biology of reproduction, 2010, 10.1095/biolreprod.110.083824
  • The Urokinase-Type Plasminogen Activator Contributes to cAMP-Induced Steroidogenesis in MA-10 Leydig Cells, Jacques J. Tremblay, Zoheir B. Demmouche, Endocrines, 2022, 10.3390/endocrines3030037
  • Friend of GATA (FOG)-1 and FOG-2 differentially repress the GATA-dependent activity of multiple gonadal promoters., Viger RS, Robert NM, Jacques J. Tremblay, Endocrinology, 2002, 10.1210/en.2002-220280
  • Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti‐Müllerian hormone receptor type 2 transcription in mouse MA‐10 Leydig cells, Jacques J. Tremblay, Robert S. Viger, Kenley Joule Pierre, Samir Mehanovic, Andrology, 2022, 10.1111/andr.13266
  • Nuclear receptors, testosterone, and posttranslational modifications in human INSL3 promoter activity in testicular Leydig cells., Laguë E, Robert NM, Jacques J. Tremblay, Annals of the New York Academy of Sciences, 2009, 10.1111/j.1749-6632.2008.03807.x
  • The nuclear receptors SF1 and LRH1 are expressed in endometrial cancer cells and regulate steroidogenic gene transcription by cooperating with AP-1 factors., Jacques J. Tremblay, Brousseau C, Robert NM, Vaillant MJ, Bergeron F, Dubé C, Cancer letters, 2009, 10.1016/j.canlet.2008.10.008
  • In Vitro Exposure of Leydig Cells to an Environmentally Relevant Mixture of Organochlorines Represses Early Steps of Steroidogenesis, Tremblay, Jacques J., Bailey, Janice L., Njembele, Annick N. Enangue, Biology of Reproduction, 2014, 10.1095/BIOLREPROD.113.116368
  • Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity., Turner TT, Palmer LA, Reardon MA, Woodson RI, Jacques J. Tremblay, Lysiak JJ, Kirby JL, Journal of andrology, 2009, 10.2164/jandrol.108.006155
  • New insights into the regulation of mammalian sex determination and male sex differentiation., Jacques J. Tremblay, Silversides DW, Viger RS, Vitamins and hormones, 2005, 10.1016/s0083-6729(05)70013-3
  • The nuclear receptors NUR77 and SF1 play additive roles with c-JUN through distinct elements on the mouse Star promoter., Jacques J. Tremblay, Luc J. Martin, Journal of molecular endocrinology, 2009, 10.1677/jme-08-0095
  • Molecular regulation of steroidogenesis in endocrine Leydig cells, Tremblay, Jacques J., Steroids, 2015, 10.1016/J.STEROIDS.2015.08.001
  • Transcription factor GATA-4 enhances Mullerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1, Viger, RS, Tremblay, JJ, Molecular Endocrinology, 1999, 10.1210/ME.13.8.1388
  • MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells, Tremblay, J. J., Brousseau, C., Di-Luoffo, M., Andrology, 2016, 10.1111/ANDR.12150
  • FOG-2 and DAX-1 are negative modulators of GATA-4/SF-1 synergism in Sertoli cells, Viger, RS, Tremblay, JJ, Biology of Reproduction, 2000
  • Expression of ladybird-like homeobox 2 (LBX2) during ovarian development and folliculogenesis in the mouse., Jacques J. Tremblay, Robert NM, Moisan V, Journal of molecular histology, 2010, 10.1007/s10735-010-9291-5
  • A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis, Robert S. Viger, Jacques J. Tremblay, Julia Picard, Marie France Bouchard, International Journal of Molecular Sciences, 2022, 10.3390/ijms231912009
  • The orphan nuclear receptor NR4A1 regulates insulin-like 3 gene transcription in Leydig cells., Jacques J. Tremblay, Luc J. Martin, Robert NM, Biology of reproduction, 2006, 10.1095/biolreprod.105.044560
  • Calcium-dependent Nr4a1 expression in mouse Leydig cells requires distinct AP1/CRE and MEF2 elements, Tremblay, Jacques J., Robert, Nicholas M., Abdou, Houssein S., Journal of Molecular Endocrinology, 2016, 10.1530/JME-15-0202
  • Transcription of platelet-derived growth factor receptor α in Leydig cells involves specificity protein 1 and 3., Jacques J. Tremblay, Bagu ET, Bergeron F, Journal of molecular endocrinology, 2011, 10.1530/jme-10-0145
  • The Calcium Signaling Pathway Regulates Leydig Cell Steroidogenesis through a Transcriptional Cascade Involving the Nuclear Receptor NR4A1 and the Steroidogenic Acute Regulatory Protein, Tremblay, Jacques J., Villeneuve, Gabrielle, Abdou, Houssein S., Endocrinology, 2013, 10.1210/EN.2012-1767
  • Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells†., Jacques J. Tremblay, Viger RS, Talbot P, de Mattos K, Mendoza-Villarroel RE, Mehanovic S, Biology of reproduction, 2021, 10.1093/biolre/ioab131
  • Expression of Nur77 and its target genes StAR and HSD3B2 in endometrial cancer cell lines: Implication for local steroid production, Tremblay, JJ, Vaillant, MJ, Biology of Reproduction, 2005
  • ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription in MA-10 and MLTC-1 Leydig Cells, Jacques J Tremblay, Robert S Viger, Clémence Belleannée, Gabriel Henrique Campolina-Silva, Félix-Olivier Dumas, Karine de Mattos, Endocrinology, 2023, 10.1210/endocr/bqad120
  • Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene, Drouin, J, Gauthier, Y, Therrien, M, Lanctot, C, Tremblay, JJ, Lamonerie, T, Genes & Development, 1996, 10.1101/GAD.10.10.1284
  • THE INSL3 GENE IS A DIRECT TARGET FOR THE NUCLEAR RECEPTOR COUP-TFII IN MA-10 LEYDIG CELLS, Tremblay, Jacques J., Brousseau, Catherine, Camire, Etienne, Mendoza, Raifish, Andrology, 2013
  • The PTX family of homeodomain transcription factors during pituitary developments, Tremblay, JJ, Lanctot, C, Lamonerie, T, Lamolet, B, Drouin, J, Molecular and Cellular Endocrinology, 1998, 10.1016/S0303-7207(98)00026-4
  • The Nuclear Receptor NR2F2 Activates Star Expression and Steroidogenesis in Mouse MA-10 and MLTC-1 Leydig Cells, Tremblay, Jacques J., Brousseau, Catherine, Martin, Luc J., Robert, Nicholas M., Mendoza-Villarroel, Raifish E., Biology of Reproduction, 2014, 10.1095/BIOLREPROD.113.115790
  • KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 leydig cells, Tremblay, Jacques J., Bergeron, Francis, Robert, Nicholas M., Mendoza-Villarroel, Raifish E., Tremblay, Maxime A., Journal of Molecular Endocrinology, 2016, 10.1530/JME-15-0139
  • The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells, Jacques J Tremblay, Robert S Viger, Raifish E Mendoza-Villarroel, Samir Mehanovic, Journal of the Endocrine Society, 2019, 10.1210/js.2019-00266
  • GATA factors and the nuclear receptors, steroidogenic factor 1/liver receptor homolog 1, are key mutual partners in the regulation of the human 3beta-hydroxysteroid dehydrogenase type 2 promoter., Viger RS, Jacques J. Tremblay, Simard J, Robert NM, Hiroaki Taniguchi, Luc J. Martin, Molecular endocrinology, 2005, 10.1210/me.2004-0257
  • Novel roles for GATA transcription factors in the regulation of steroidogenesis., Viger RS, Jacques J. Tremblay, The Journal of steroid biochemistry and molecular biology, 2003, 10.1016/s0960-0760(03)00211-5
  • Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis., Jacques J. Tremblay, Bomgardner D, Moisan V, BMC developmental biology, 2008, 10.1186/1471-213x-8-22
  • Growth Hormone-induced STAT5B Regulates Star Gene Expression Through a Cooperation With cJUN in Mouse MA-10 Leydig Cells, Jacques J Tremblay, Catherine Brousseau, Karine de Mattos, Raifish E Mendoza-Villarroel, Kenley Joule Pierre, Samir Mehanovic, Nicholas M Robert, Francis Bergeron, Pierre-Olivier Hébert-Mercier, Endocrinology, 2022, 10.1210/endocr/bqab267
  • Dynamic Expression of the Homeobox Factor PBX1 during Mouse Testis Development, Jacques J. Tremblay, Catherine Brousseau, Vanessa Moisan, Endocrines, 2022, 10.3390/endocrines3010002
  • Expression of the ladybird-like homeobox 2 (LBX2) factor during ovarian development in the mouse, Tremblay, Jacques J., Bomgardner, Damela, Moisan, Vanessa, Biology of Reproduction, 2007, 10.1093/BIOLREPROD/77.S1.207C
  • The Ptx family of homeodomain transcription factors, Tremblay, JJ, Lanctot, C, Drouin, J, Medecine Sciences: M/S, 1998, 10.4267/10608/1040
  • Transcriptional properties of Pitx1 and its role in hindlimb specification, Tremblay, JJ, Poulin, G, Moreau, A, Marcil, A, Lanctot, C, Drouin, J, Developmental Dynamics, 2000
  • Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells, Tremblay, Jacques J., Bergeron, Francis, Daems, Caroline, Di-Luoffo, Mickael, Biology of Reproduction, 2015, 10.1095/BIOLREPROD.114.127761
  • Hormones and Signaling Pathways Involved in the Stimulation of Leydig Cell Steroidogenesis, Jacques J. Tremblay, Kenley Joule Pierre, Karine de Mattos, Endocrines, 2023, 10.3390/endocrines4030041
  • cAMP-induced expression of the orphan nuclear receptor Nur77 in MA-10 Leydig cells involves a CaMKI pathway., Jacques J. Tremblay, El-Asmar B, Boucher N, Luc J. Martin, Journal of andrology, 2009, 10.2164/jandrol.108.006387

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Léa Lafranchise - Maîtrise avec mémoire - En cours
  • Laurie Boudreau - Maîtrise avec mémoire - En cours
  • Kenley Joule Pierre - Doctorat - En cours
  • Raifish Eduardo Mendoza - Maîtrise avec mémoire - 2012/05
  • Madeline Tyre - Maîtrise avec mémoire - 2013/01
  • Gabriel Garon - Maîtrise avec mémoire - 2013/01
  • Caroline Daems - Doctorat - 2015/01
  • François Péloquin - Maîtrise avec mémoire - 2018/05
  • Samir Mehanovic - Doctorat - 2021/05
  • Oona Delmas - Maîtrise avec mémoire - 2021/05
  • Shirley Ferrier Tarin - Maîtrise avec mémoire - 2023/05
  • Zoheir Benaoumer Demmouche - Doctorat - 2023/09
  • Karine De Mattos - Doctorat - 2024/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Médecine moléculaire

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Disponibilité d'encadrement d'étudiant(e)s

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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