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Jacques-P. Tremblay

Professeur titulaire

jacques-p.tremblay@fmed.ulaval.ca

Site personnel

Département de médecine moléculaire

Centre thématique de recherche en neurosciences

Centre de recherche du CHU de Québec - Université Laval

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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

Médecine régénératrice et médecine moléculaire
Neurosciences et santé mentale

Domaines de recherche

Thérapie génique et moléculaire
Biotechnologies médicales, n.c.a.

Projets de recherche en cours

Correction by Prime editing of point mutations responsible for Cystic fibrosis in Quebec province - Génome Québec - Cibler des mutations rares, orphelines de CFTR, McGill University, co-chercheur - 2025-04-01 au 2028-03-30
In vivo correction by CRISPR PRIME editing of mutations responsible for Duchenne Muscular Dystrophy - Vaincre Duchenne Canada, chercheur principal - 2023-12-01 au 2026-11-30
Correction of point mutations responsible for Dysferlinopathy using Prime Editing Renouvellement 2025-2026 - Jain Foundation Inc., chercheur principal - 2025-02-01 au 2026-01-31

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Financements des 2 dernières années

Removal of the GAA repeat with the CRISPR/Cas9 system in Friedreich patient cells and in the YG8sR mouse model - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-10-01 au 2024-09-30
Correcting point mutations responsible for Dysferlinopathy using Prime Editing - Jain Foundation Inc., chercheur principal - 2023-08-01 au 2024-07-31
Développement de microdispositifs transdermiques peu invasifs pour l’administration d'acides nucléiques : vaccination et thérapie génique - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, Université de Montréal, co-chercheur - 2023-04-01 au 2024-03-31
Development of an AAV library - Conseil national de recherches du Canada - Programmes et initiatives de R&D collaboratifs, chercheur principal - 2022-04-01 au 2024-03-31
Développement d'un traitement pour prévenir ou ralentir la progression de la maladie d'Alzheimer - Fondation Famille Lemaire, chercheur principal - 2023-11-08 au 2024-03-31
Correction with the Prime editing technology of point mutations responsible for Duchenne Muscular Dystrophy - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-03-01 au 2024-02-29
PRIME editing correction of the T1709M mutation responsible for some cases of Ryanodine receptor type I-related myopathies - RYR-1 Foundation, chercheur principal - 2021-07-01 au 2023-06-30
Development of a rapid and simple test to detect the COVID-19 variants that can be used in remote areas and developing countries - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, chercheur principal - 2021-06-01 au 2022-05-31

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Publications

Transplantation of normal or genetically modified myoblasts for the treatment of hereditary or acquired diseases, , Journal de la Societe de biologie, 2001
Clarifying misconceptions about myoblast transplantation in myology, , Molecular therapy : the journal of the American Society of Gene Therapy, 2014, 10.1038/mt.2014.57
Pretreatment of myoblast cultures with basic fibroblast growth factor increases the efficacy of their transplantation in mdx mice, , Muscle & nerve, 1995, 10.1002/mus.880180806
Baclofen modifies via the release of monoamines the synaptic depression, frequency facilitation, and posttetanic potentiation observed at an identified cholinergic synapse of Aplysia californica, , Canadian journal of physiology and pharmacology, 1981, 10.1139/y81-039
Growth factor coinjection improves the migration potential of monkey myogenic precursors without affecting cell transplantation success, , Cell transplantation, 2009, 10.3727/096368909X470900
Immune reactions after myoblast transplantation in mouse muscles, , Transplantation proceedings, 1992
A light and electron microscopic study of dystrophin localization at the mouse neuromuscular junction, , Synapse (New York, N.Y.), 1992, 10.1002/syn.890100202
Cell Therapy in Myology: Dynamics of Muscle Precursor Cell Death after Intramuscular Administration in Non-human Primates, , Molecular therapy. Methods & clinical development, 2017, 10.1016/j.omtm.2017.05.002
Mechanism of increasing dystrophin-positive myofibers by myoblast transplantation: study using mdx/beta-galactosidase transgenic mice, , Acta neuropathologica, 1996, 10.1007/s004010050456
Immunosuppression with FK 506 insures good success of myoblast transplantation in MDX mice, , Transplantation proceedings, 1994
In vivo stimulation of a cholinergic synapse of the chick ciliary ganglion induces a reduction in the number of dense core vesicles, , Neuroscience letters, 1981, 10.1016/0304-3940(81)90176-2
Myopathy in a rhesus monkey with biopsy findings similar to human sporadic inclusion body myositis, , Neuromuscular disorders : NMD, 2013, 10.1016/j.nmd.2012.10.020
Intraarterial injection of muscle-derived CD34(+)Sca-1(+) stem cells restores dystrophin in mdx mice, , The Journal of cell biology, 2001, 10.1083/jcb.152.2.335
Enzymatic activity and morphological differentiation in de novo innervated human muscle cultures, , European journal of histochemistry : EJH, 1994
Improved success of myoblast transplantation in mdx mice by blocking the myostatin signal, , Transplantation, 2005, 10.1097/01.tp.0000167379.27872.2b
Emerging Perspectives on Prime Editor Delivery to the Brain, Jacques P. Tremblay, Marc Lavertu, Avi Schroeder, Joël Rousseau, Yaoyao Lu, Sina Ramezanian, Eli BenDavid, Pharmaceuticals, 2024, 10.3390/ph17060763
Dysferlin expression after normal myoblast transplantation in SCID and in SJL mice, , Neuromuscular disorders : NMD, 2002, 10.1016/s0960-8966(01)00254-1
Electrotransfer of the full-length dog dystrophin into mouse and dystrophic dog muscles, , Human gene therapy, 2010, 10.1089/hum.2010.024
Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro, , Molecular therapy. Nucleic acids, 2021, 10.1016/j.omtn.2021.02.032
Use of fluorescent latex microspheres (FLMs) to follow the fate of transplanted myoblasts, , The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1993, 10.1177/41.10.8245416
Telomerase can extend the proliferative capacity of human myoblasts, but does not lead to their immortalization, , Molecular cancer research : MCR, 2003
Myoblast transplantation: a possible surgical treatment for a severe pediatric disease, , Surgery today, 2010, 10.1007/s00595-009-4242-z
Miniature endplate potential amplitudes corrected for spatial decay are not normally distributed, , Brain research, 1985, 10.1016/0006-8993(85)91339-3
Growth factors improve the in vivo migration of human skeletal myoblasts by modulating their endogenous proteolytic activity, , Transplantation, 2004, 10.1097/01.tp.0000131175.60047.eb
Morphological changes in presynaptic terminals of the chick ciliary ganglion after stimulation in vivo. A stereological study showing a net loss of total membrane, , Experimental brain research, 1981, 10.1007/BF00238388
Immunosuppression with monoclonal antibodies and CTLA4-Ig after myoblast transplantation in mice, , Transplantation, 1996, 10.1097/00007890-199610150-00015
Laminin-111: a potential therapeutic agent for Duchenne muscular dystrophy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2010, 10.1038/mt.2010.165
Synaptic depression at a synapse in Aplysia californica: analysis in terms of a material flow model of neurotransmitter, , Brain research, 1976, 10.1016/0006-8993(76)90379-6
Targeted Gene Addition of Microdystrophin in Mice Skeletal Muscle via Human Myoblast Transplantation, , Molecular therapy. Nucleic acids, 2013, 10.1038/mtna.2012.55
Antibody formation after myoblast transplantation in Duchenne-dystrophic patients, donor HLA compatible, , Transplantation proceedings, 1993
Effects of vitamin C on cytotherapy-mediated muscle regeneration, , Cell transplantation, 2013, 10.3727/096368912X657846
Gene Therapy in Duchenne’s Muscular Dystrophy, , 2009
The CRISPR system can correct or modify the expression of genes responsible for hereditary diseases, , Medecine sciences : M/S, 2015, 10.1051/medsci/20153111016
In vitro bromodeoxyuridine labeling of nuclei: application to myotube hybridization, , The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1991, 10.1177/39.10.1940314
Myogenesis: where and how can we get skeletal myoblasts?, , Dialogues in cardiovascular medicine : DCM, 2003
Macrophages improve survival, proliferation and migration of engrafted myogenic precursor cells into MDX skeletal muscle, , PloS one, 2012, 10.1371/journal.pone.0046698
Scale-up of a myoblast culture process, , Journal of biotechnology, 2001, 10.1016/s0168-1656(01)00291-7
AG490 improves the survival of human myoblasts in vitro and in vivo, , Cell transplantation, 2012, 10.3727/096368912X655028
Human myoblast transplantation between immunohistocompatible donors and recipients produces immune reactions, , Transplantation proceedings, 1992
Section VI - Novel Genetic Technologies. 6.2 Gene Therapy, , 2009
Mosaic expression of dystrophin in the cerebellum of heterozygote dystrophic (mdx) mice, , Neuromuscular disorders : NMD, 1992, 10.1016/s0960-8966(06)80002-7
Generation of human endometrial knockout cell lines with the CRISPR/Cas9 system confirms the prostaglandin F2α synthase activity of aldo-ketoreductase 1B1, , Molecular human reproduction, 2014, 10.1093/molehr/gau023
Percutaneous versus surgical delivery of autologous myoblasts after chronic myocardial infarction: an in vivo cardiovascular magnetic resonance study, , Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2010, 10.1002/ccd.22204
Reduction of postjunctional fold density and depth in dystrophic mice, , Synapse (New York, N.Y.), 1988, 10.1002/syn.890020206
An AAV9 coding for frataxin clearly improved the symptoms and prolonged the life of Friedreich ataxia mouse models, , Molecular therapy. Methods & clinical development, 2014, 10.1038/mtm.2014.44
The protective mutation A673T in amyloid precursor protein gene decreases Aβ peptides production for 14 forms of Familial Alzheimer's Disease in SH-SY5Y cells, , PloS one, 2020, 10.1371/journal.pone.0237122
Myoblast transplantation: a brief review of the problems and of some solutions, , Basic and applied myology : BAM, 1997
Expression of human dystrophin following the transplantation of genetically modified mdx myoblasts, , Gene therapy, 1998, 10.1038/sj.gt.3300753
Non-uniform distribution of miniature endplate potential amplitudes along the length of the frog neuromuscular junction, , Neuroscience letters, 1987, 10.1016/0304-3940(87)90147-9
Polymerase chain reaction-based assay to assess the success of myoblast transplantation in mdx mice, , Transplantation proceedings, 1994
Online Manuscript Processing for Cell Transplantation, , Cell transplantation, 2006, 10.3727/000000006783981738
Myoblast transplantations lead to the expression of the laminin alpha 2 chain in normal and dystrophic (dy/dy) mouse muscles, , Gene therapy, 1999, 10.1038/sj.gt.3300889
Anti-inflammatory effect of transforming growth factor-beta1 in myoblast transplantation, , Transplantation, 1998, 10.1097/00007890-199803270-00005
CSCI/RCPSC Henry Friesen Lecture: Cell therapy for Duchenne muscular dystrophy, , Clinical and investigative medicine. Medecine clinique et experimentale, 2006
Successful myoblast allotransplantation in mdx mice using rapamycin, , Transplantation, 1995
Non monotonic morphometric changes produced at mouse neuromuscular junctions following in vivo stimulation at various frequencies, , Experimental brain research, 1986, 10.1007/BF00237590
Human Muscle Precursor Cells Form Human-Derived Myofibers in Skeletal Muscles of Nonhuman Primates: A Potential New Preclinical Setting to Test Myogenic Cells of Human Origin for Cell Therapy of Myopathies, , Journal of neuropathology and experimental neurology, 2020, 10.1093/jnen/nlaa110
Inhibiting myostatin with follistatin improves the success of myoblast transplantation in dystrophic mice, , Cell transplantation, 2008, 10.3727/096368908784153913
A monoclonal antibody to beta-tubulin distinguishes a subset of neurons and axons in the chick ciliary ganglion, , Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 1985, 10.1139/o85-065
Frequency facilitation and post-tetanic potentiation of a unitary synaptic potential in Aplysia californica are limited by different processes, , Brain research, 1976, 10.1016/0006-8993(76)90377-2
Generation of lentiviral vectors for use in skeletal muscle research, , Methods in molecular biology (Clifton, N.J.), 2012, 10.1007/978-1-61779-343-1_16
Control of inflammatory damage by anti-LFA-1: increase success of myoblast transplantation, , Cell transplantation, 1997
Benzodiazepines modify synaptic depression, frequency facilitation and PTP an identified cholinergic synapse of Aplysia, , Life sciences, 1980, 10.1016/0024-3205(80)90130-7
Cytomegalovirus and myoblast transplantation, , Lancet (London, England), 1991, 10.1016/0140-6736(91)93090-v
Fibrin gel improves the survival of transplanted myoblasts, , Cell transplantation, 2012, 10.3727/096368911X576018
Tubulyzine, a novel tri-substituted triazine, prevents the early cell death of transplanted myogenic cells and improves transplantation success, , Biochemistry and cell biology = Biochimie et biologie cellulaire, 2003, 10.1139/o03-054
A synthetic mechano growth factor E Peptide enhances myogenic precursor cell transplantation success, , American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2007, 10.1111/j.1600-6143.2007.01927.x
Ex vivo modification of cells to induce a muscle-based expression, , Current gene therapy, 2006, 10.2174/156652306779010651
Inflammatory damage following first-generation replication-defective adenovirus controlled by anti-LFA-1, , Journal of leukocyte biology, 1997, 10.1002/jlb.61.4.533
Increased Frataxin Expression Induced in Friedreich Ataxia Cells by Platinum TALE-VP64s or Platinum TALE-SunTag, , Molecular therapy. Nucleic acids, 2018, 10.1016/j.omtn.2018.04.009
Interrelation between MEPP amplitude and MEPP frequency in different regions along the frog neuromuscular junction, , Brain research, 1987, 10.1016/0006-8993(87)90404-5
Current Clinical Applications of In Vivo Gene Therapy with AAVs, , Molecular therapy : the journal of the American Society of Gene Therapy, 2021, 10.1016/j.ymthe.2020.12.007
CRISPR-SCReT (CRISPR-Stop Codon Read Through) method to control Cas9 expression for gene editing, , Gene therapy, 2022, 10.1038/s41434-021-00297-z
Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases, , Molecular therapy : the journal of the American Society of Gene Therapy, 2013, 10.1038/mt.2013.4
Transplantation of normal and DMD myoblasts expressing the telomerase gene in SCID mice, , Biochemical and biophysical research communications, 2000, 10.1006/bbrc.2000.2735
Ischemic central necrosis in pockets of transplanted myoblasts in nonhuman primates: implications for cell-transplantation strategies, , Transplantation, 2007, 10.1097/01.tp.0000288322.94252.22
CRISPR-induced deletion with SaCas9 restores dystrophin expression in dystrophic models in vitro and in vivo, , 2018, 10.1101/378331
Lymphocyte infiltration following allo- and xenomyoblast transplantation in mice, , Transplantation proceedings, 1994
Electrotransfer of naked DNA in the skeletal muscles of animal models of muscular dystrophies, , Gene therapy, 2001, 10.1038/sj.gt.3301484
Dystrophin expression in myofibers of Duchenne muscular dystrophy patients following intramuscular injections of normal myogenic cells, , Molecular therapy : the journal of the American Society of Gene Therapy, 2004, 10.1016/j.ymthe.2003.11.023
Transplanted myoblasts can migrate several millimeters to fuse with damaged myofibers in nonhuman primate skeletal muscle, , Journal of neuropathology and experimental neurology, 2011, 10.1097/NEN.0b013e31822a6baa
A new pro-migratory activity on human myogenic precursor cells for a synthetic peptide within the E domain of the mechano growth factor, , Experimental cell research, 2007, 10.1016/j.yexcr.2006.10.032
Male-specific competitive PCR for the quantification of transplanted cells in mice, , BioTechniques, 1999, 10.2144/99273bm05
Successful histocompatible myoblast transplantation in dystrophin-deficient mdx mouse despite the production of antibodies against dystrophin, , The Journal of cell biology, 1995, 10.1083/jcb.131.4.975
The paracrine effect: pivotal mechanism in cell-based cardiac repair, , Journal of cardiovascular translational research, 2010, 10.1007/s12265-010-9198-2
Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients, , Molecular therapy : the journal of the American Society of Gene Therapy, 2013, 10.1038/mt.2013.111
Use of normal and genetically modified myoblasts for the treatment of myopathies, , 2000
Localization of dystrophin in the Purkinje cells of normal mice, , Neuroscience letters, 1992, 10.1016/0304-3940(92)90309-u
Fast turnover of clear vesicle membrane in frog sympathetic ganglion, , Neuroscience, 1986, 10.1016/0306-4522(86)90093-x
Cyclophosphamide immunosuppression does not permit successful myoblast allotransplantation in mouse, , Neuromuscular disorders : NMD, 1995, 10.1016/0960-8966(95)00011-b
Non-uniform release at the frog neuromuscular junction: evidence of morphological and physiological plasticity, , Brain research, 1987, 10.1016/0165-0173(87)90019-1
FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer, , Human gene therapy, 1995, 10.1089/hum.1995.6.11-1391
Nucleofection of muscle-derived stem cells and myoblasts with phiC31 integrase: stable expression of a full-length-dystrophin fusion gene by human myoblasts, , Molecular therapy : the journal of the American Society of Gene Therapy, 2004, 10.1016/j.ymthe.2004.05.034
Successful Correction by Prime Editing of a Mutation in the RYR1 Gene Responsible for a Myopathy, Jacques P. Tremblay, Joël Rousseau, Kelly Godbout, Cells, 2023, 10.3390/cells13010031
Myotubes can be formed within implanted adipose tissue, , Transplantation proceedings, 1992
Increased Expression of Laminin Subunit Alpha 1 Chain by dCas9-VP160, , Molecular therapy. Nucleic acids, 2017, 10.1016/j.omtn.2016.11.004
Is dystrophin present in the nerve terminal at the neuromuscular junction? An immunohistochemical study of the heterozygote dystrophic (mdx) mouse, , Synapse (New York, N.Y.), 1991, 10.1002/syn.890070207
Development of a web course on gene therapy by the international consortium of gene therapy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2014, 10.1038/mt.2014.11
Efficacy and site-specificity of adenoviral vector integration mediated by the phage φC31 integrase, , Human gene therapy methods, 2012, 10.1089/hgtb.2012.122
Successive injections in mdx mice of myoblasts grown with bFGF, , Neuromuscular disorders : NMD, 1996, 10.1016/0960-8966(96)00004-1
Cell therapy in muscular dystrophies: many promises in mice and dogs, few facts in patients, , Expert opinion on biological therapy, 2015, 10.1517/14712598.2015.1057564
Resting and stimulated values of model parameters governing transmitter release at a synapse in Aplysia californica, , Brain research, 1976, 10.1016/0006-8993(76)90378-4
Increased interferon-gamma mRNA expression following alloincompatible myoblast transplantation is inhibited by FK506, , Muscle & nerve, 1996, 10.1002/(SICI)1097-4598(199607)19:73.0.CO;2-B
Cholinergic agents affect two receptors that modulate transmitter release at a central synapse in Aplsia californica, , Brain research, 1975, 10.1016/0006-8993(75)90657-5
Myoblasts derived from normal hESCs and dystrophic hiPSCs efficiently fuse with existing muscle fibers following transplantation, , Molecular therapy : the journal of the American Society of Gene Therapy, 2012, 10.1038/mt.2012.188
Gene therapy: a strategy for the treatment of inherited muscle diseases?, , Current opinion in pharmacology, 2001, 10.1016/s1471-4892(01)00052-2
Modulation of synapse RC1-R15 of Aplysia californica by fiber(s) of the right connective, , Canadian journal of physiology and pharmacology, 1982, 10.1139/y82-094
Current status of pharmaceutical and genetic therapeutic approaches to treat DMD, , Molecular therapy : the journal of the American Society of Gene Therapy, 2011, 10.1038/mt.2011.59
Therapeutic Strategies for Dystrophin Replacement in Duchenne Muscular Dystrophy, , Frontiers in medicine, 2022, 10.3389/fmed.2022.859930
Utilization of myoblasts from transgenic mice to evaluate the efficacy of myoblast transplantation, , Muscle & nerve, 1994, 10.1002/mus.880170903
Prevention by anti-LFA-1 of acute myoblast death following transplantation, , Journal of immunology (Baltimore, Md. : 1950), 1997
Not an inside job: how can transplantation of relatively few exogenous satellite cells do what thousands of endogenous cells cannot?, , Molecular therapy : the journal of the American Society of Gene Therapy, 2011, 10.1038/mt.2010.276
Removal of the GAA repeat in the heart of a Friedreich’s ataxia mouse model using CjCas9, Jacques P. Tremblay, Nathalie Majeau, Catherine Gérard, Pouiré Yaméogo, Gene Therapy, 2023, 10.1038/s41434-023-00387-0
1,25-dihydroxyvitamin D3 increases the transplantation success of human muscle precursor cells in SCID mice, , Cell transplantation, 2007, 10.3727/000000007783464876
Scanning electron microscopic study of the neuromuscular junction of dystrophic mice, , Experimental neurology, 1988, 10.1016/0014-4886(88)90200-2
Losartan enhances the success of myoblast transplantation, , Cell transplantation, 2012, 10.3727/096368911X576045
Induction of tolerance across fully mismatched barriers by a nonmyeloablative treatment excluding antibodies or irradiation use, , Cell transplantation, 2006, 10.3727/000000006783981521
Base editing strategy allows insertion of the A673T mutation in APP gene to prevent the development of Alzheimer’s disease, Jacques P. Tremblay, Gabriel Lamothe, Tom Bertin, Francis-Gabriel Bégin, Joël Rousseau, Antoine Guyon, 2020, 10.1101/2020.10.27.357830
Human myoblast transplantation: a simple assay for tumorigenicity, , Neuromuscular disorders : NMD, 1991, 10.1016/0960-8966(91)90120-h
A case for immunosuppression for myoblast transplantation in duchenne muscular dystrophy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2009, 10.1038/mt.2009.125
CD56+ Muscle Derived Cells but Not Retinal NG2+ Perivascular Cells of Nonhuman Primates are Myogenic after Intramuscular Transplantation in Immunodeficient Mice, , Journal of stem cell research & therapy, 2017, 10.4172/2157-7633.1000377
Another new super muscle stem cell leaves unaddressed the real problems of cell therapy for duchenne muscular dystrophy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2008, 10.1038/mt.2008.243
A Potential New Therapeutic Approach for Friedreich Ataxia: Induction of Frataxin Expression With TALE Proteins, , Molecular therapy. Nucleic acids, 2013, 10.1038/mtna.2013.41
Intramuscular transplantation of myogenic cells in primates: importance of needle size, cell number, and injection volume, , Cell transplantation, 2014, 10.3727/096368912X661337
Heterogeneous labeling of mitochondrial membrane, endoplasmic reticulum, neurofilaments and synaptic vesicles with a lectin (DBA-peroxidase), , Neuroscience letters, 1982, 10.1016/0304-3940(82)90003-9
Synaptic contacts on glial cells in the abdominal ganglion of Aplysia californica, , The Journal of comparative neurology, 1979, 10.1002/cne.901880304
Meganucleases can restore the reading frame of a mutated dystrophin, , Gene therapy, 2010, 10.1038/gt.2010.26
Therapeutic effects of exon skipping and losartan on skeletal muscle of mdx mice, , Pathology international, 2014, 10.1111/pin.12190
In Vitro Correction of Point Mutations in the DYSF Gene Using Prime Editing, Jacques P. Tremblay, Sina Ramezani, Laura Bastrenta, Marie Dubost, Gabriel Lamothe, Joël Rousseau, Camille Bouchard, International Journal of Molecular Sciences, 2025, 10.3390/ijms26125647
Telomerase allows the immortalization of T antigen-positive DMD myoblasts: a new source of cells for gene transfer application, , Gene therapy, 2000, 10.1038/sj.gt.3301132
Necrosis, sarcolemmal damage and apoptotic events in myofibers rejected by CD8+ lymphocytes: Observations in nonhuman primates, , Neuromuscular disorders : NMD, 2012, 10.1016/j.nmd.2012.05.005
Myoblast transplantation in monkeys: control of immune response by FK506, , Journal of neuropathology and experimental neurology, 1996, 10.1097/00005072-199606000-00002
Rapid selection of donor myoblast clones for muscular dystrophy therapy using cell surface expression of NCAM, , European journal of histochemistry : EJH, 1993
Prime Editing for Human Gene Therapy: Where Are We Now?, Jacques P. Tremblay, Kelly Godbout, Cells, 2023, 10.3390/cells12040536
Role of non-major histocompatibility complex antigens in the rejection of transplanted myoblasts, , Transplantation, 1997, 10.1097/00007890-199703270-00016
The urokinase plasminogen activator: an interesting way to improve myoblast migration following their transplantation, , Experimental cell research, 2002, 10.1006/excr.2002.5642
Prior culture with concanavalin A increases intramuscular migration of transplanted myoblast, , Muscle & nerve, 1998, 10.1002/(sici)1097-4598(199803)21:33.0.co;2-5
Myogenic progenitor cells derived from human induced pluripotent stem cell are immune-tolerated in humanized mice, , Stem cells translational medicine, 2021, 10.1002/sctm.19-0452
Muscle glucose-6-phosphate dehydrogenase deficiency: restoration of enzymatic activity in hybrid myotubes, , Muscle & nerve, 1993, 10.1002/mus.880160604
Early and massive death of myoblasts transplanted into skeletal muscle : responsible factors and potential solutions, , Current opinion in organ transplantation, 2007
Gene Editing for Duchenne Muscular Dystrophy Using the CRISPR/Cas9 Technology: The Importance of Fine-tuning the Approach, , Molecular therapy : the journal of the American Society of Gene Therapy, 2016, 10.1038/mt.2016.191
Myoblast survival enhancement and transplantation success improvement by heat-shock treatment in mdx mice, , Transplantation, 2004, 10.1097/01.tp.0000121503.01535.f5
Increase in the proliferative capacity of human myoblasts by using the T antigen under the vimentin promoter control, , Muscle & nerve, 1997, 10.1002/(sici)1097-4598(199704)20:43.0.co;2-b
Boutons originating from the same axon do not participate equally in synaptic transmission, , Neuroscience letters, 1982, 10.1016/0304-3940(82)90342-1
Endonucleases: tools to correct the dystrophin gene, , The journal of gene medicine, 2011, 10.1002/jgm.1611
High efficiency of muscle regeneration after human myoblast clone transplantation in SCID mice, , The Journal of clinical investigation, 1994, 10.1172/JCI117011
Confirmation of donor-derived dystrophin in a duchenne muscular dystrophy patient allotransplanted with normal myoblasts, , Muscle & nerve, 2016, 10.1002/mus.25129
Successful myoblast transplantation in primates depends on appropriate cell delivery and induction of regeneration in the host muscle, , Experimental neurology, 1999, 10.1006/exnr.1998.6973
Increased number per area of peptidergic and cholinergic vesicles in synapses of the chick ciliary ganglion following 10 Hz in vivo stimulation, , Neuroscience letters, 1983, 10.1016/0304-3940(83)90542-6
Muscle fibers of mdx mice are more vulnerable to exercise than those of normal mice, , Neuromuscular disorders : NMD, 1997, 10.1016/s0960-8966(97)00115-6
The effects of hemicholinium-3 on synaptic depression, facilitation, and post-tetanic potentiation at an identified synapse of Aplysia californica, , Canadian journal of physiology and pharmacology, 1980, 10.1139/y80-064
Meeting of the Cell Transplantation Society in Miami, , Cell transplantation, 1997
Transplantation of Myogenic Cells in Duchenne Muscular Dystrophy Patients: Clinical Findings, , 2014, 10.1016/b978-0-12-410396-2.00026-8
Overexpression of follistatin in human myoblasts increases their proliferation and differentiation, and improves the graft success in SCID mice, , Cell transplantation, 2009, 10.3727/096368909X470865
Expression of major histocompatibility complex antigens on human myoblasts, , Transplantation proceedings, 1991
Efficient myoblast transplantation in mice immunosuppressed with monoclonal antibodies and CTLA4 Ig, , Transplantation proceedings, 1997, 10.1016/s0041-1345(97)00166-8
Heterosynaptic inhibition modifies the presynaptic plasticities of the transmission process at the synapse in Aplysia californica, , Brain research, 1976, 10.1016/0006-8993(76)90381-4
CRISPR-Cas9 Gene Therapy for Duchenne Muscular Dystrophy, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2022, 10.1007/s13311-022-01197-9
Delivery of RNAs to Specific Organs by Lipid Nanoparticles for Gene Therapy, Jacques P. Tremblay, Kelly Godbout, Pharmaceutics, 2022, 10.3390/pharmaceutics14102129
Presynaptic modulating effects of GABA on depression, facilitation, and posttetanic potentiation of a cholinergic synapse in Aplysia californica, , Canadian journal of physiology and pharmacology, 1977, 10.1139/y77-174
Integration of a Raman spectroscopy system to a robotic-assisted surgical system for real-time tissue characterization during radical prostatectomy procedures, , Journal of biomedical optics, 2019, 10.1117/1.JBO.24.2.025001
Increased myogenic potential and fusion of matrilysin-expressing myoblasts transplanted in mice, , Cell transplantation, 1999, 10.1177/096368979900800502
A Comment on Muscle Xenografts Reproduce Key Molecular Features of Facioscapulohumeral Muscular Dystrophy : What Is New and What Has Already been Done and Reported but Was Not Quoted?, , Cell transplantation, 2020, 10.1177/0963689720939120
Electroporation as a method to induce myofiber regeneration and increase the engraftment of myogenic cells in skeletal muscles of primates, , Journal of neuropathology and experimental neurology, 2013, 10.1097/NEN.0b013e31829bac22
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Myoblast transplantation in whole muscle of nonhuman primates, , Journal of neuropathology and experimental neurology, 2000, 10.1093/jnen/59.3.197
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Deletion of the GAA repeats from the human frataxin gene using the CRISPR-Cas9 system in YG8R-derived cells and mouse models of Friedreich ataxia, , Gene therapy, 2017, 10.1038/gt.2016.89
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Myotubes Formed De Novo by Myoblasts Injected into the Scar of Myocardial Infarction Persisted for 16 Years in a Patient: Importance for Regenerative Medicine in Degenerative Myopathies, , Stem cells translational medicine, 2019, 10.1002/sctm.18-0202
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Characterization of frataxin gene network in Friedreich's ataxia fibroblasts using the RNA-Seq technique, , Mitochondrion, 2016, 10.1016/j.mito.2016.06.003
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Assessment of a symptomatic Duchenne muscular dystrophy carrier 20 years after myoblast transplantation from her asymptomatic identical twin sister, , Neuromuscular disorders : NMD, 2013, 10.1016/j.nmd.2013.04.007
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Sarcolemmal Complement Membrane Attack Complex Deposits During Acute Rejection of Myofibers in Nonhuman Primates, , Journal of neuropathology and experimental neurology, 2019, 10.1093/jnen/nly106
Myoblast transplantation: techniques in nonhuman primates as a bridge to clinical trials, , 2011
Small-molecule inhibitors of proteasome increase CjCas9 protein stability, Jacques P. Tremblay, Cedric Happi Mbakam, Nathalie Majeau, Pouiré Yaméogo, PLOS ONE, 2023, 10.1371/journal.pone.0280353
Use of repeating dispensers to increase the efficiency of the intramuscular myogenic cell injection procedure, , Cell transplantation, 2006, 10.3727/000000006783981648
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Dynamics of the early immune cellular reactions after myogenic cell transplantation, , Cell transplantation, 2002, 10.3727/000000002783985378
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Human myoblast transplantation in immunodeficient and immunosuppressed mice: evidence of rejection, , Muscle & nerve, 1994, 10.1002/mus.880170214
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Development of an AAV9 coding for a 3XFLAG-TALEfrat#8-VP64 able to increase in vivo the human frataxin in YG8R mice, , Gene therapy, 2016, 10.1038/gt.2016.36
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Induction of Anoikis following myoblast transplantation into SCID mouse muscles requires the Bit1 and FADD pathways, , American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2007, 10.1111/j.1600-6143.2007.01830.x
Vascular endothelial growth factor reduced hypoxia-induced death of human myoblasts and improved their engraftment in mouse muscles, , Gene therapy, 2008, 10.1038/sj.gt.3303059
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Fatima El Husseiny - Doctorat - En cours
Sina Ramezani - Doctorat - En cours
Ayesha Siddika - Doctorat - En cours
Jing Jiang - Doctorat - En cours
Félix Veillette - Maîtrise avec mémoire - En cours
Gabriel Lamothe - Doctorat - En cours
Seyed Mohammadreza Mirinezhad - Post-doctorat - En cours
Camille Bouchard - Doctorat - En cours
Yaoyao Lu - Doctorat - En cours
Gege Zhao - Doctorat - En cours
Maheswaran Kesavan - Doctorat - En cours
Antoine Guyon - Doctorat - 2021/01
Malek Aloui - Maîtrise avec mémoire - 2021/09
Solange Gni-Fiene Yanyabe - Maîtrise avec mémoire - 2022/01
Guillaume Tremblay - Maîtrise avec mémoire - 2022/05
Annabelle Fortin-Archambault - Maîtrise avec mémoire - 2022/05
Pouiré Yameogo - Doctorat - 2023/01
Cedric Happi Mbakam - Doctorat - 2023/05
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