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Jean-François Bilodeau

Professeur titulaire

Jean-François Bilodeau
jean-francois.bilodeau@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Pédagogie des sciences de la santé
Reproduction, génétique, périnatalité et développement
Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Nutrition et métabolisme
  • Maladies lipidiques
  • Désordres métaboliques
  • Diabète
  • Métabolisme
  • Obésité
Santé circulatoire et respiratoire
  • Hypertension artérielle
  • Maladies cardiovasculaires
  • Athérosclérose
  • Système cardiovasculaire
Santé de la mère, des enfants et des adolescents
  • Prééclampsie
  • Dépistage prénatal et néonatal
  • Périnatalité
  • Prématurité

Projets de recherche

  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2017-04-01 au 2022-03-31

Publications

  • Increased placental phospholipase A2 gene expression and free F2-isoprostane levels in response to oxidative stress in preeclampsia, Bilodeau, J.F., Julien, P., Greffard, K., Larose, J., Brien, M., Placenta, 2017, 10.1016/j.placenta.2017.05.004
  • Altered placental glutathione peroxidase mRNA expression in preeclampsia according to the presence or absence of labor, Bilodeau, J.-F., St-Pierre, I., Moisan, V., Roland-Zejly, L., Placenta, 2011, 10.1016/j.placenta.2010.11.005
  • Sex-specific perinatal expression of glutathione peroxidases during mouse lung development, Bilodeau, J.-F., Tremblay, Y., Simard, M., Boucher, E., Tondreau, M.Y., Molecular and Cellular Endocrinology, 2012, 10.1016/j.mce.2012.01.022
  • Estrogen selectively up-regulates the phospholipid hydroperoxide glutathione peroxidase in the oviducts, Bilodeau, J.-F., MacLaren, L.A., Kimmins, S., Lapointe, J., Endocrinology, 2005, 10.1210/en.2004-1373
  • Epithelial and stromal uterine cells cultured in vitro protect bovine sperm from hydrogen peroxide, Sirard, M.-A., Fortier, M., Asselin, E., Lemieux, D., Bilodeau, J.-F., Lapointe, S., Theriogenology, 2000, 10.1016/S0093-691X(00)00354-X
  • Specific systemic antioxidant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood, Bilodeau, J.-F., Thomas, N., Roland, L., Boutet, M., American Journal of Obstetrics and Gynecology, 2009, 10.1016/j.ajog.2008.12.031
  • Thiols prevent H2O2-mediated loss of sperm motility in cryopreserved bull semen, Sirard, M.-A., Gagnon, C., Blanchette, S., Bilodeau, J.-F., Theriogenology, 2001, 10.1016/S0093-691X(01)00562-3
  • Impact of dairy intake on plasma f2-isoprostane profiles in overweight subjects with hyperinsulinemia: A randomized crossover trial, Rudkowska, I., Larose, J., Greffard, K., Bilodeau, J.-F., Khorraminezhad, L., Nutrients, 2021, 10.3390/nu13062088
  • Reactive oxygen species-mediated loss of bovine sperm motility in egg yolk Tris extender: Protection by pyruvate, metal chelators and bovine liver or oviductal fluid catalase, Sirard, M.-A., Cormier, N., Blanchette, S., Bilodeau, J.-F., Theriogenology, 2002, 10.1016/S0093-691X(01)00702-6
  • F 2 -isoprostanes and fatty acids profile in early pregnancy complicated by pre-existing diabetes, Rudkowska, I., Julien, P., Fraser, W.D., Audibert, F., Berthiaume, L., Greffard, K., Larose, J., Bilodeau, J.-F., Taschereau-Charron, A., Prostaglandins Leukotrienes and Essential Fatty Acids, 2018, 10.1016/j.plefa.2018.07.008
  • Effects of nonsteroidal antiinflammatory drugs on oxidative pathways in A/J mice, Castonguay, A., Chung, F.-L., Wang, M., Bilodeau, J.-F., Free Radical Biology and Medicine, 1995, 10.1016/0891-5849(94)00099-6
  • Effect of dietary organic and inorganic selenium on antioxidant status, embryo development, and reproductive performance in hyperovulatory first-parity gilts, Matte, J.J., Quesnel, H., Bilodeau, J.-F., Laforest, J.-P., Giguère, A., Audet, I., Fortier, M.-E., Journal of Animal Science, 2012, 10.2527/jas.2010-3340
  • Current concepts in the use of antioxidants for the treatment of preeclampsia., Hubel, C.A., Bilodeau, J.F., Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC, 2003, 10.1016/S1701-2163(16)31003-9
  • Levels of antioxidant defenses are decreased in bovine spermatozoa after a cycle of freezing and thawing, Gagnon, C., Sirard, M.-A., Chatterjee, S., Bilodeau, J.-F., Molecular Reproduction and Development, 2000, 10.1002/(SICI)1098-2795(200003)55:3<282::AID-MRD6>3.0.CO;2-7
  • The polyol pathway in the bovine oviduct, Bilodeau, J.-F., Sullivan, R., Frenette, G., Lapointe, J., Côté, I., Laflamme, J., Larose, J., Molecular Reproduction and Development, 2012, 10.1002/mrd.22067
  • Review: Maternal and placental antioxidant response to preeclampsia - Impact on vasoactive eicosanoids, Bilodeau, J.-F., Placenta, 2014, 10.1016/j.placenta.2013.11.013
  • Maternal vitamin D, oxidative stress, and pre-eclampsia, Fraser, W.D., Audibert, F., Leduc, L., Nuyt, A.M., Bi, W.G., Abenhaim, H.A., Luo, Z.-C., Julien, P., Bilodeau, J.-F., Wei, S.Q., International Journal of Gynecology and Obstetrics, 2021, 10.1002/ijgo.13559
  • Plasma F2-isoprostane class VI isomers at 12-18 weeks of pregnancy are associated with later occurrence of preeclampsia, Julien, P., Fraser, W.D., Audibert, F., Moisan, V., Greffard, K., Larose, J., Qin Wei, S., Bilodeau, J.-F., Free Radical Biology and Medicine, 2015, 10.1016/j.freeradbiomed.2015.05.012
  • Semen characteristics of genetically identical quadruplet bulls, Sullivan, R., Leclerc, P., Bailey, J.L., Twagiramungu, H., Kroetsch, T., Bilodeau, J.-F., Masseau, I., Lessard, C., Theriogenology, 2003, 10.1016/S0093-691X(02)01256-6
  • Plasma interleukin-18 (IL-18) levels are correlated with antioxidant vitamin coenzyme Q10 in preeclampsia, Bilodeau, J.-F., Julien, P., Boutet, M., Bélanger, M.-C., Gagné, A., Roland, L., Acta Obstetricia et Gynecologica Scandinavica, 2010, 10.3109/00016340903576020
  • Analysis of F2 -isoprostanes in plasma of pregnant women by HPLC-MS/MS using a column packed with core-shell particles, Bilodeau, J.-F., Julien, P., Larose, J., Journal of Lipid Research, 2013, 10.1194/jlr.D034553
  • Existence of compensatory defense mechanisms against oxidative stress and hypertension in preeclampsia., Bilodeau, J.F., Julien, P., Fraser, W.D., Berthiaume, L., Boutet, M., Bélanger, M.C., Gagné, A., Roland, L., Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy, 2010, 10.3109/10641950902777689
  • Alterations of fatty acid profiles in gestational diabetes and influence of the diet, Rudkowska, I., Julien, P., Morisset, A.-S., Bilodeau, J.-F., Da Silva, M.S., Taschereau-Charron, A., Maturitas, 2017, 10.1016/j.maturitas.2017.01.014
  • The use of antioxidants in pre-eclampsia, Bilodeau, J.-F., Studies on Women's Health, 2013, 10.1007/978-1-62703-041-0_6
  • The plasma antioxidant vitamin status of the INTAPP cohort examined: The unsuspected importance of β-carotene and γ-tocopherol in preeclampsia, Julien, P., Fraser, W.D., Audibert, F., Greffard, K., Gagné, A., Bilodeau, J.-F., Pregnancy Hypertension, 2021, 10.1016/j.preghy.2021.06.009
  • Marginal Impact of Brown Seaweed Ascophyllum nodosum and Fucus vesiculosus Extract on Metabolic and Inflammatory Response in Overweight and Obese Prediabetic Subjects, Hélène Jacques, Jean-François Bilodeau, Stanley John Weisnagel, Nadine Leblanc, Valérie Guay, Julie Marois, Marlène Vodouhè, Marine Drugs, 2022, 10.3390/md20030174
  • Physical fitness is associated with prostaglandin F2α isomers during pregnancy, Marc, I., Greffard, K., Brien, M., Pronovost, E., Larose, J., Bisson, M., Bilodeau, J.-F., Prostaglandins Leukotrienes and Essential Fatty Acids, 2019, 10.1016/j.plefa.2019.05.001
  • Hormonal and spatial regulation of nitric oxide synthases (NOS) (Neuronal NOS, Inducible NOS, and Endothelial NOS) in the oviducts, Bilodeau, J.-F., MacLaren, L.A., Gauvreau, D., Kimmins, S., St-Pierre, I., Roy, M., Lapointe, J., Endocrinology, 2006, 10.1210/en.2005-1548
  • Modulation of the biomarkers of inflammation and oxidative stress by ruminant trans fatty acids and dairy proteins in vascular endothelial cells (HUVEC), Rudkowska, I., Barbier, O., Julien, P., Greffard, K., Larose, J., Bilodeau, J.-F., Da Silva, M.S., Prostaglandins Leukotrienes and Essential Fatty Acids, 2017, 10.1016/j.plefa.2017.09.016
  • Glutathione peroxidase-1 expression enhances recovery of human breast carcinoma cells from hyperoxic cell cycle arrest, Mirault, M.-E., Faure, R., Petrov, P., Carrier, C., Piedboeuf, B., Patenaude, A., Bilodeau, J.-F., Free Radical Biology and Medicine, 2002, 10.1016/S0891-5849(02)01013-4
  • Minireview: Semen cryopreservation in domestic animals: A damaging and capacitating phenomenon, Cormier, N., Bilodeau, J.-F., Bailey, J.L., Journal of Andrology, 2000
  • Antioxidant defenses are modulated in the cow oviduct during the estrous cycle, Bilodeau, J.-F., Lapointe, J., Biology of Reproduction, 2003, 10.1095/biolreprod.102.007476
  • Expression of superoxide dismutases in the bovine oviduct during the estrous cycle, Bilodeau, J.-F., Gauvreau, D., Roy, M., Theriogenology, 2008, 10.1016/j.theriogenology.2008.05.042
  • Effects of Labor on Placental Expression of Superoxide Dismutases in Preeclampsia, Bilodeau, J.-F., St-Pierre, I., Fradette, C., Acteau, G., Beauchemin, D., Roland, L., Placenta, 2010, 10.1016/j.placenta.2010.02.007
  • F2-isoprostanes are correlated with trans fatty acids in the plasma of pregnant women, Bilodeau, J.-F., Wei, S.Q., Audibert, F., Fraser, W.D., Greffard, K., Julien, P., Larose, J., Prostaglandins Leukotrienes and Essential Fatty Acids, 2014, 10.1016/j.plefa.2014.09.010
  • Expression of prostaglandin E synthases in the bovine oviduct, Bilodeau, J.-F., Fortier, M.A., Roy, M., Moisan, V., Gauvreau, D., Theriogenology, 2010, 10.1016/j.theriogenology.2009.08.006
  • Statistical and machine-learning analyses in nutritional genomics studies, Rudkowska, I., Bilodeau, J.-F., Droit, A., Leclercq, M., Khorraminezhad, L., Nutrients, 2020, 10.3390/nu12103140
  • Increased resistance of GPx-1 transgenic mice to tumor promoter-induced loss of glutathione peroxidase activity in skin, Mirault, M.-E., Bilodeau, J.-F., International Journal of Cancer, 1999, 10.1002/(SICI)1097-0215(19990315)80:6<863::AID-IJC11>3.0.CO;2-9
  • Dietary fats and F2-isoprostanes: A review of the clinical evidence, Rudkowska, I., Julien, P., Bilodeau, J.-F., Da Silva, M.S., Critical Reviews in Food Science and Nutrition, 2017, 10.1080/10408398.2016.1196646
  • Perinatal oxidative stress may affect fetal ghrelin levels in humans, Levy, E., Garofalo, C., Xiao, L., Audibert, F., Julien, P., Fraser, W.D., Monique Nuyt, A., Bilodeau, J.-F., Luo, Z.-C., Scientific Reports, 2015, 10.1038/srep17881
  • Impact of cryopreservation and reactive oxygen species on DNA integrity, lipid peroxidation, and functional parameters in ram sperm, Bailey, J.L., Dufour, M., Bilodeau, J.-F., Peris, S.I., Molecular Reproduction and Development, 2007, 10.1002/mrd.20686
  • Hyperoxia induces S-phase cell-cycle arrest and p21(Cip1/Waf1)- independent Cdk2 inhibition in human carcinoma T47D-H3 cells, Mirault, M.-E., Piedboeuf, B., Faure, R., Bilodeau, J.-F., Experimental Cell Research, 2000, 10.1006/excr.2000.4844
  • Increased Dairy Product Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 Diabetes, Rudkowska, I., Bilodeau, J.-F., Droit, A., Gagnon, C., Weisnagel, S.J., Julien, P., Leclercq, M., Greffard, K., O'Connor, S., Molecular Nutrition and Food Research, 2019, 10.1002/mnfr.201900126
  • Industrial and Ruminant Trans-Fatty Acids-Enriched Diets Differentially Modulate the Microbiome and Fecal Metabolites in C57BL/6 Mice, Iwona Rudkowska, Nicolas Bertrand, Jane Foster, Arnaud Droit, Jean-François Bilodeau, Mickael Leclercq, Karine Greffard, Emma Tolsdorf, Miranda Green, Farzad Mohammadi, Nutrients, 2023, 10.3390/nu15061433
  • Trans Fatty Acids Suppress TNF-α-Induced Inflammatory Gene Expression in Endothelial (HUVEC) and Hepatocellular Carcinoma (HepG2) Cells, Rudkowska, I., Barbier, O., Bilodeau, J.-F., Julien, P., Da Silva, M.S., Lipids, 2017, 10.1007/s11745-017-4243-4
  • Long chain omega-3 fatty acids and their oxidized metabolites are associated with reduced prostate tumor growth, Fradet, V., Julien, P., Fradet, Y., Durand, T., Bergeron, A., Galano, J.-M., Oger, C., Roy, J., Robitaille, K., Larose, J., Gevariya, N., Bilodeau, J.-F., Prostaglandins Leukotrienes and Essential Fatty Acids, 2021, 10.1016/j.plefa.2020.102215
  • Placental dimethyl acetal fatty acid derivatives are elevated in preeclampsia, Bilodeau, J.F., Julien, P., Rudkowska, I., Berthiaume, L., Brien, M., Placenta, 2017, 10.1016/j.placenta.2017.01.129
  • Antioxidant requirements for bovine oocytes varies during in vitro maturation, fertilization and development, Sirard, M.A., Bilodeau, J.F., Ali, A.A., Theriogenology, 2003, 10.1016/S0093-691X(02)01125-1

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Maxime Tondreau - Maîtrise avec mémoire - 2011/05
  • Jessica Larose - Maîtrise avec mémoire - 2013/05
  • Mélanie Brien - Maîtrise avec mémoire - 2017/01
  • Leila Khorraminezhad - Doctorat - 2022/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Médecine moléculaire

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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