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Jean-Philippe Lambert

Professeur agrégé

Jean-Philippe Lambert
jean-philippe.lambert.2@ulaval.ca
Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Signalisation cellulaire et cancer
Génomique et protéomique
  • Mécanismes biologiques et biochimiques
  • Protéomique fonctionnelle et structurale
Organisation et fonctions biologiques

Projets de recherche

  • Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines - Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université du Québec à Montréal - UQAM , co-chercheur - 2024-04-01 au 2030-03-31
  • Chromatin structure and function as a readout of physical interactions - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2024-04-01 au 2029-03-31
  • Régulation dynamique de la couronne fibreuse dans l'espace et le temps - Fonds de recherche du Québec - Nature et technologies - Projet de recherche en équipe, co-chercheur - 2024-04-01 au 2027-03-31
  • Étude des interactions bromodomain-dépendantes et de leurs impacts sur le cycle de transcription - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2022-07-01 au 2026-06-30
  • Mitochondria bound to lipid droplets as new regulators of insulin resistance - Diabète Canada - Subvention de fonctionnement : Mettre fin au diabète prix 2022, co-chercheur - 2022-12-01 au 2025-11-30
  • Elucidation of bromodomain functions within SWI/SNF complexes - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
  • Tetrahymena thermophila - un model évolutionnaire divergent pour découvrir de nouveau modes de régulation transcriptionnelle - Conseil de recherches en sciences naturelles et génie Canada, Fonds de recherche du Québec - Nature et technologies - Programme NOVA- FRQNT-CRSNG pour chercheurs et chercheuses en début de carrière (PILOTE), chercheur principal - 2022-03-15 au 2025-03-14
  • Structural characterization of full-length BET proteins and their functional implications to cancer - Société de recherche sur le cancer - Subvention de fonctionnement, chercheur principal - 2022-09-01 au 2024-08-31
  • TBC1D9: therapeutic target of the aggressiveness of triple negative breast cancer - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-03-01 au 2024-02-29
  • Caractérisation du protéome mitochondrial de la prostate - CHU de Québec – Université Laval – CHUL - Subvention de fonctionnement de centre, co-chercheur - 2022-09-21 au 2023-03-31
  • Investigating TBC1D9 therapeutic potential for triple negative breast cancer - CHU de Québec – Université Laval – CHUL - Subvention de fonctionnement de centre, chercheur principal - 2022-09-21 au 2023-03-31
  • Predict to prevent: Advanced proteomics profiling for precision medicine - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), co-chercheur - 2021-03-23 au 2022-09-30
  • Using BET bromodomain inhibitors to create phenotypic lethality in melanoma - Société de recherche sur le cancer, Génome Québec - Subvention de fonctionnement, chercheur principal - 2020-09-01 au 2022-08-31
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-06-01 au 2022-05-31
  • Characterization of the scaffolding roles of bromodomain containing proteins at the level of chromatin - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2017-04-01 au 2022-03-31

Publications

  • Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia, Filippakopoulos, P., Knapp, S., Vassiliou, G., Schwaller, J., Gingras, A.-C., Samsonova, A., Muller, S., Brennan, P., Ley, S.V., Ingham, R., Guetzoyan, L., Nikbin, N., Tallant, C., Lingard, H., Wang, C.-Y., Fujisawa, T., Monteiro, O., Fedorov, O., Wells, C., Dovey, O., Lambert, J.-P., Leonards, K., Picaud, S., Science Advances, 2016, 10.1126/sciadv.1600760
  • The CRAPome: A contaminant repository for affinity purification-mass spectrometry data, Nesvizhskii, A.I., Gingras, A.-C., Ewing, R.M., Raught, B., Washburn, M.P., Bennett, K.L., Cristea, I.M., Gstaiger, M., Mohammed, S., Heck, A.J.R., Choi, H., Colinge, J., Superti-Furga, G., Aebersold, R., Coulombe, B., Durocher, D., Pawson, T., Badillo, B.G., Lin, Z.-Y., Goudreault, M., Dunham, W.H., Fermin, D., Faubert, D., Bouchard, A., Al-Hakim, A., Hubner, N.C., Bagshaw, R.D., Halim, V.A., Low, T.Y., Sardiu, M.E., Hauri, S., Miteva, Y.V., Li, T., St-Denis, N.A., Lambert, J.-P., Couzens, A.L., Wright, Z., Mellacheruvu, D., Nature Methods, 2013, 10.1038/nmeth.2557
  • Functional proteomics characterization of the human acetyl lysine machinery, , 3rd Canadian Conference on Epigenetics. Epigenomics in Development and Disease, 2016
  • Stir bar sorptive extraction based on restricted access material for the direct extraction of caffeine and metabolites in biological fluids, Dieter Lubda, Elizabeth Kwong, Wayne M. Mullett, Jean-Philippe Lambert, Journal of Chromatography A, 2005, 10.1016/j.chroma.2005.03.119
  • Physical Interplay Between Histone H3/H4 Chaperones Revealed Through mChIP Characterization of Chromatin in Budding Yeast, , Chromatin Structure & Function, 2009
  • Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry, Figeys, D., Smith, J.C., Lambert, J.-P., Vasilescu, J., Denis, N.J., Proteomics, 2007, 10.1002/pmic.200600410
  • Data Independent Acquisition analysis in ProHits 4.0, Gingras, A.-C., Choi, H., Nesvizhskii, A.I., Bandeira, N., Raught, B., Tyers, M., Larsen, B., Lambert, J.-P., Wang, J., Tsou, C.-C., Zhang, J.P., Knight, J.D.R., Liu, G., Journal of Proteomics, 2016, 10.1016/j.jprot.2016.04.042
  • AIRE is a critical spindle-associated protein in embryonic stem cells, Rossant, J., Gingras, A.-C., Cockburn, K., Lambert, J.-P., Gu, B., eLife, 2017, 10.7554/eLife.28131
  • Exploring the rewiring of BET protein interactome following bromodomain inhibition, , 10th annual symposium of the Canadian National Proteomics Network, 2018
  • A Novel Approach for the Analysis of Histone H2A and Htz1 Interaction Partners by Modified Chromatin Immunoprecipitation and Mass Spectrometry, , 5th Annual World Congress Human Proteome Organization (HUPO), 2006
  • Molecular dissection of the mode of resistance to BET bromodomain inhibitors in melanoma, , 5th Canadian Cancer Research Conference, 2019
  • Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor, Baetz, K., Bryan, J., Bennett, S.A.L., Figeys, D., Ahmed, F., Swayne, L.A., Lambert, J.-P., Kabbani, N., Kennedy, M.A., PLoS Genetics, 2011, 10.1371/journal.pgen.1001299
  • Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7, Sicheri, F., Durocher, D., Gingras, A.-C., Caudy, A.A., Laister, R., Huang, H., Manczyk, N., Ng, T.F., Lambert, J.-P., Szilard, R.K., Maisonneuve, P., Wan, L.C.K., Nucleic Acids Research, 2017, 10.1093/nar/gkw1181
  • Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2, Leach, M.D., Cowen, L.E., Khalimonchuk, O., Gingras, A.-C., Lambert, J.-P., Wong, E.O.Y., Bohovych, I., Xie, J.L., Microbial Cell, 2017, 10.15698/mic2017.10.594
  • Regulation of septin dynamics by the saccharomyces cerevisiae lysine acetyltransferase NuA4, Baetz, K., Figeys, D., Couture, J.-F., Fong, Y., Zhou, H., Lambert, J.-P., Lau, A., Mitchell, L., PLoS ONE, 2011, 10.1371/journal.pone.0025336
  • (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells, Arrowsmith, C.H., Vedadi, M., Zaph, C., Owen, D.R., Bunnage, M.E., Brown, P.J., Sudol, M., Rossi, F.M.V., Braam, M.J.S., Grimley, R.L., Benn, C.L., Roberts, L., Gerstenberger, B.S., Fish, P.V., Al-Awar, R., Gingras, A.-C., Aman, A., Couzens, A.L., Lambert, J.-P., Kennedy, S., Allali-Hassani, A., Marcellus, R., Kuznetsova, E., Senisterra, G.A., Schapira, M., Freeman, S.A., Wu, H., Zeng, H., Dong, A., Tatlock, J.H., Oudhoff, M.J., Li, F., Barsyte-Lovejoy, D., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1407358111
  • A Novel Approach for the Analysis of Chromatin Bound Protein Complex Applied to the Study of Htz1p and Yta7p, , 50th Canadian Society of Biochemistry, Molecular and Cellular Biology conference, 2007
  • Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation, Knapp, S., Birnbaum, M.J., Odgren, P.R., Gingras, A.C., Müller, S., Brennan, P.E., Buffa, F., Oppermann, U.C.T., Haendler, B., Bayle, E.D., Igoe, N.M., Fish, P.V., Owen, D.R., Daniels, D.L., Heidenreich, D., Savitsky, P., Fedele, V., Gerstenberger, B.S., Yapp, C., Rogers, C., Lambert, J.-P., Van Stiphout, R.G., Hwang, S.-Y., Witwicka, H., Fedorov, O., Tallant, C., Meier, J.C., ACS Chemical Biology, 2017, 10.1021/acschembio.7b00481
  • Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination, Côté, J., Couture, J.-F., Sugiyama, T., Verreault, A., Gingras, A.-C., Brunzelle, J.S., Tremblay, V., Chen, Y., Lambert, J.-P., Li, J., Billon, P., Molecular Cell, 2017, 10.1016/j.molcel.2016.10.033
  • Large-Scale Proteomics Characterization of the Budding Yeast Chromatin by mChIP, , 8th annual world congress of the human proteome organization (HUPO), 2009
  • Machine learning analysis identifies genes differentiating triple negative breast cancers, Durocher, F., Diorio, C., Lambert, J.-P., Corbeil, J., Laviolette, F., Déraspe, M., Ouellette, G., Agbo, L., Osseni, M.A., Kothari, C., Scientific Reports, 2020, 10.1038/s41598-020-67525-1
  • Proximity biotinylation and CRISPR-Cas9, two approaches working together for defining the chromatin environment at specific genomic locus, , 23è journée scientifique des étudiants du CRC, 2019
  • Incorporating DNA shearing in standard affinity purification allows simultaneous identification of both soluble and chromatin-bound interaction partners, Gingras, A.-C., Pawson, T., Tucholska, M., Lambert, J.-P., Journal of Proteomics, 2014, 10.1016/j.jprot.2013.12.022
  • The tale of two domains: Proteomics and genomics analysis of SMYD2, a new histone methyltransferase, Figeys, D., Skerjanc, I.S., Elisma, F., Al-Madhoun, A.S., Lambert, J.-P., Abu-Farha, M., Molecular and Cellular Proteomics, 2008, 10.1074/mcp.M700271-MCP200
  • BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation, Groth, A., Côté, J., Gingras, A.-C., Yang, X.-J., Paquet, E., Johansen, J.V., Alabert, C., Zhao, X., Lee, S.-B., Lambert, J.-P., González-Aguilera, C., Lalonde, M.-E., Roques, C., Vlassis, A., Feng, Y., EMBO Journal, 2016, 10.15252/embj.201591293
  • Toward a System View of Acetyl Lysine Signaling, , 2011 Scientific Retreat of the Lunenfeld-Tanenbaum Research Institute, 2011
  • Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition, Gingras, A.-C., Tate, S., Bonner, R., Pawson, T., Aebersold, R., Vidal, M., Lindquist, S., Zhong, Q., Lin, Z.-Y., Taipale, M., Larsen, B., Couzens, A.L., Ivosev, G., Lambert, J.-P., Nature Methods, 2013, 10.1038/nmeth.2702
  • Revisiting the budding yeast protein interactome: histones, their chaperones and beyond, , 2009 Progress in Systems Biology Symposium, 2009
  • Measurement and analysis of lysine acetylation by KAT complexes in vitro and in vivo, Côté, J., Lambert, J.-P., Lashgari, A., Methods in Molecular Biology, 2019, 10.1007/978-1-4939-9434-2_5
  • Two-Color Cell Array Screen Reveals Interdependent Roles for Histone Chaperones and a Chromatin Boundary Regulator in Histone Gene Repression, Andrews, B.J., Greenblatt, J., Hughes, T.R., Figeys, D., Nislow, C., Peña-Castillo, L., Tsui, K., van Bakel, H., Lambert, J.-P., Kainth, P., Fillingham, J., Molecular Cell, 2009, 10.1016/j.molcel.2009.06.023
  • Étude fonctionnelle des protéines à bromodomonaines des complexes SWI/SNF, , Séminaires Étudiants de l’axe endocrinologie et néphrologie, 2019
  • Of proteins and DNA - Proteomic role in the field of chromatin research, Figeys, D., Baetz, K., Lambert, J.-P., Molecular BioSystems, 2009, 10.1039/b907925b
  • Progress toward the therapeutic modulation of the human acetylome, , 2013 Scientific Retreat of the Lunenfeld-Tanenbaum Research Institute, 2013
  • CRISPR-based tools to interrogate a locus-specific proteome, , Séminaires Étudiants de l’axe endocrinologie et néphrologie, 2019
  • Histone recognition and large-scale structural analysis of the human bromodomain family, Knapp, S., Arrowsmith, C.H., Gingras, A.-C., Pawson, T., Müller, S., Volkmer, R., Felletar, I., Barsyte-Lovejoy, D., Lambert, J.-P., Keates, T., Mangos, M., Picaud, S., Filippakopoulos, P., Cell, 2012, 10.1016/j.cell.2012.02.013
  • Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity, Baetz, K., Figeys, D., Skerjanc, I.S., Al-Madhoun, A.S., Gerdes, M., Lambert, J.-P., Mitchell, L., Molecular and Cellular Biology, 2008, 10.1128/MCB.01653-07
  • The bromodomain-containing protein Ibd1 links multiple chromatin-related protein complexes to highly expressed genes in Tetrahymena thermophila, Fillingham, J., Pearlman, R.E., Gingras, A.-C., Thuppu Mudalige, C., Burtch, A., Ponce, M., Nabeel-Shah, S., Lambert, J.-P., Garg, J., Saettone, A., Epigenetics and Chromatin, 2018, 10.1186/s13072-018-0180-6
  • Conserved Asf1-importin β physical interaction in growth and sexual development in the ciliate Tetrahymena thermophila, Fillingham, J.S., Pearlman, R.E., Gingras, A.-C., Pawson, T., Radovani, E., Retnasothie, D.V., Bertucci, V., Nabeel-Shah, S., Marquez, S., Karsou, A., Lambert, J.-P., Garg, J., Journal of Proteomics, 2013, 10.1016/j.jprot.2013.09.018
  • Exploring the rewiring of BET protein interactome following bromodomain inhibition, , 10th annual symposium of the Canadian National Proteomics Network, 2018
  • Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling, Pawson, T., Iscove, N.N., Gingras, A.-C., Dick, J.E., Minden, M.D., Herrington, R., Milyavsky, M., Adissu, H.A., Lambert, J.-P., Kofler, M.M., Jin, J., Gish, G., Ruston, J., Frelin, C., Louria-Hayon, I., Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1319665110
  • Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains, Gingras, A.-C., Filippakopoulos, P., Wilson, M.D., Bandeira, N., Pelletier, L., Stucki, M., Newman, J.A., St-Denis, N., Gonzalez-Badillo, B., Knight, J.D.R., Tucholska, M., Lin, Z.-Y., Abdouni, H., Gupta, G.D., Uusküla-Reimand, L., Savitsky, P., Hou, H., Fujisawa, T., Picaud, S., Lambert, J.-P., Molecular Cell, 2019, 10.1016/j.molcel.2018.11.006
  • Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging, Poirier, D., Lambert, J.-P., Barbeau, X., Roy, J., Ngueta Djiemeny, A., Maltais, R., Bioorganic and Medicinal Chemistry, 2020, 10.1016/j.bmc.2020.115368
  • Proteomics investigation of bromodomains functional roles in SWI/SNF complexes, , 11th annual symposium of the Canadian National Proteomics Network, 2019
  • Proteomics contribution to the elucidation of the steroid hormone receptors functions, Lambert, J.-P., Agbo, L., Journal of Steroid Biochemistry and Molecular Biology, 2019, 10.1016/j.jsbmb.2019.105387
  • A Targeted Proteomic Approach for the Study of the Human Acetylome, , 4th annual Canadian National Proteomics Network. , 2012
  • Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes, Gingras, A.-C., Knight, J.D.R., Go, C., Tucholska, M., Lambert, J.-P., Journal of Proteomics, 2015, 10.1016/j.jprot.2014.09.011
  • Using proximity biotinylation at defined genomic locus to investigate the scaffolding roles of bromodomain containing proteins, , Journée de la recherche du CHU de Québec – Université Laval 2019, 2019
  • MChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases, Baetz, K., Figeys, D.A., Côté, J., Basu, A., Ning, Z., Zhou, H., Lambert, J.-P., Hamza, A., Steunou, A.-L., Pourhanifeh-Lemeri, R., Cotrut, M., Huard, S., Mitchell, L., Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1218515110
  • Revisiting the budding yeast protein interactome: histones, their chaperones and beyond, , 2009 Progress in Systems Biology Symposium, 2009
  • Étude fonctionnelle des protéines à bromodomonaines des complexes SWI/SNF, , Journée de la recherche du CHU de Québec – Université Laval, 2019
  • Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution, Goding, C.R., Mazza, D., Steingrímsson, E., Wilmanns, M., Lambert, J.-P., Davidson, I., Patton, E.E., Lu, X., Middleton, M., Filippakopoulos, P., Schuster-Böckler, B., Thomas, B., Lisle, R., Suer, E., Freter, R., Strub, T., Lu, M., Zeng, Z., Schepsky, A., Friedrichsen, H., Pogenberg, V., Loffreda, A., Siddaway, R., Louphrasitthiphol, P., Molecular Cell, 2020, 10.1016/j.molcel.2020.05.025
  • A Novel Approach for the Analysis of Histone H2A and Htz1 Interaction Partners by Modified Chromatin Immunoprecipitation and Mass Spectrometry, , 2nd Annual Progress in Systems Biology at Ottawa, 2006
  • Use of data dependent and independent mass spectrometry acquisition for the systematic study of the human acetylome components, , 9th annual US HUPO meeting, 2013
  • Using proximity biotinylation at defined genomic locus to investigate the scaffolding roles of bromodomain containing proteins, , 11th annual symposium of the Canadian National Proteomics Network, 2019
  • Emerging tools to investigate bromodomain functions, Lambert, J.-P., Filippakopoulos, P., Kougnassoukou Tchara, P.-E., Methods, 2020, 10.1016/j.ymeth.2019.11.003
  • Defining the budding yeast chromatin-associated interactome, Figeys, D., Baetz, K., Greenblatt, J., Siahbazi, M., Fillingham, J., Lambert, J.-P., Molecular Systems Biology, 2010, 10.1038/msb.2010.104
  • JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage, Canitrot, Y., Trouche, D., Cote, J., Lambert, J.-P., Loehr, J., Jang, S.-M., Humbert, J., Chailleux, C., Fages, J., PLoS Genetics, 2020, 10.1371/journal.pgen.1008511
  • Losing a BET in the nucleolus – unexpected consequences of bromodomain inhibition, , 6th annual Canadian National Proteomics Network, 2014
  • Targeted proteomics analyses of phosphorylation-dependent signalling networks, Bisson, N., Lambert, J.-P., Dionne, U., Banerjee, S.L., Journal of Proteomics, 2018, 10.1016/j.jprot.2018.02.004
  • BETting on the therapeutic modulation of the epigenome – a systematic proteomic study of the acetylome components, , 2013 Chromatin Structure & Function conference, 2013
  • Large-scale mapping of human protein-protein interactions by mass spectrometry, Figeys, D., Topaloglou, T., Morin, G.B., Moran, M.F., Adams, S.-L., Kinach, R., Muskat, B., Gladwish, K., Colwill, K., Hogue, K., Kuehl, B., Stewart, I.I., Duewel, H.S., Lambert, J.-P., Abu-Farha, M., Vasilescu, J., Sheng, Y., Ethier, M., Bukhman, Y.V., Ornatsky, O., Zhang, S., Moore, L., Heilbut, A., Ho, Y., Dharsee, M., Taylor, R., Li, M., O'Connor, L., Robinson, M.D., McBroom-Cerajewski, L., Climie, S., Taylor, P., Li, H., Elisma, F., Chu, P., Ewing, R.M., Molecular Systems Biology, 2007, 10.1038/msb4100134
  • A New Look at Protein Complexes; A Modified Chromatin Immunopurifcation Approach Applied to the Study of Histone Htz1 and Yta7, , 50th Canadian Society of Biochemistry, Molecular and Cellular Biology conference, 2007
  • Systematic study of human bromodomain specificity, , 55th annual meeting of the Canadian Society for Molecular BioSciences, 2012
  • Functional proteomics of nuclear proteins in Tetrahymena thermophila: A review, Fillingham, J., Pearlman, R.E., Lambert, J.-P., Garg, J., Nabeel-Shah, S., Saettone, A., Genes, 2019, 10.3390/genes10050333
  • New ammunition for the proteomic reactor: Strong anion exchange beads and multiple enzymes enhance protein identification and sequence coverage, Figeys, D., Hou, W., Lambert, J.-P., Zhou, H., Analytical and Bioanalytical Chemistry, 2010, 10.1007/s00216-010-3791-8
  • Invesitgation fonctionnelle des sous-unités à bromodomaines des complexes SWI/SNF chez l’humain, , 24è journée scientifique des étudiants du CRC, 2020
  • Using ProHits to store, annotate, and analyze Affinity purification-mass spectrometry (AP-MS) Data, Gingras, A.-C., Tyers, M., Raught, B., Nesvizhskii, A.I., Larsen, B., Srikumar, T., Lambert, J.-P., Choi, H., Zhang, J., Liu, G., Current Protocols in Bioinformatics, 2012, 10.1002/0471250953.bi0816s39
  • Mapping physical interactions within chromatin by proteomic approaches, Gingras, A.-C., Pawson, T., Lambert, J.-P., Proteomics, 2012, 10.1002/pmic.201100547
  • Proteomics in 2005/2006: Developments, applications and challenges, Figeys, D., Elisma, F., Lambert, J.-P., Smith, J.C., Analytical Chemistry, 2007, 10.1021/ac070741j
  • Betting on the therapeutic modulation of the epigenome – a systematic proteomic study of the acetylome components, , 2nd Canadian Conference on Epigenetics: Epigenetics, Eh!, 2014
  • Proteomic Analysis of Histones H2A/H2B and Variant Hv1 in Tetrahymena thermophila Reveals an Ancient Network of Chaperones, Fillingham, J., Pearlman, R.E., Lambert, J.-P., Gingras, A.-C., Derynck, J., Saettone, A., Garg, J., Nabeel-Shah, S., Ashraf, K., Molecular Biology and Evolution, 2019, 10.1093/molbev/msz039
  • Déployer des nouveaux outils de biotinylation de proximité pour disséquer les modes de résistance aux inhibiteurs de bromodomaines de la famille BET chez les mélanomes, , 23è journée scientifique des étudiants du CRC, 2019
  • Development of a multiplexed microfluidic proteomic reactor and its application for studying protein-protein interactions, Figeys, D., Veres, T., Pezacki, J.P., Lambert, J.-P., Hoa, X.D., Tian, R., Analytical Chemistry, 2011, 10.1021/ac200194d
  • Proteomics: From gel based to gel free, Figeys, D., Smith, J.C., Ethier, M., Lambert, J.-P., Analytical Chemistry, 2005, 10.1021/ac050586d
  • Dual action antifungal small molecule modulates multidrug efflux and TOR signaling, ECowen, L., Heitman, J., Gunatilaka, A., Gingras, A.-C., Coccetti, P., Nislow, C., Andes, D., Sanglard, D., PRoth, F., Loewith, R.J., Schmitt, L., Niewola-Staszkowska, K., Döhl, K., Ammar, R., Tripodi, F., Bahn, Y.-S., Kim, T., Lee, S.C., Averette, A.F., Lambert, J.-P., Wijeratne, E.M.K., Gunaherath, G.M.K.B., Shekhar-Guturja, T., Nature Chemical Biology, 2016, 10.1038/nchembio.2165
  • MSPLIT-DIA: Sensitive peptide identification for data-independent acquisition, Bandeira, N., Gingras, A.-C., Tate, S., Larsen, B., Lambert, J.-P., Knight, J.D.R., Tucholska, M., Wang, J., Nature Methods, 2015, 10.1038/nmeth.3655
  • Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching, Müller, S., Knapp, S., Gingras, A.-C., Burgess-Brown, N.A., Strain-Damerell, C., Lambert, J.-P., Wells, C., Yapp, C., Rogers, C.M., Philpott, M., Epigenetics and Chromatin, 2014, 10.1186/1756-8935-7-14
  • Myosin phosphatase modulates the cardiac cell fate by regulating the subcellular localization of Nkx2.5 in a Wnt/rho-associated protein kinase-dependent pathway, Skerjanc, I.S., Puri, P.L., Figeys, D., Ruel, M., Boisvenue, S., Malecova, B., Lambert, J.-P., Shelton, M., Ryan, T., Circulation Research, 2013, 10.1161/CIRCRESAHA.112.275818
  • The Med31 Conserved Component of the Divergent Mediator Complex in Tetrahymena thermophila Participates in Developmental Regulation, Fillingham, J., Pearlman, R.E., Lambert, J.-P., Greenblatt, J., Pu, S., Marquez, S., Ponce, M., Cadorin, M., Nabeel-Shah, S., Saettone, A., Garg, J., Current Biology, 2019, 10.1016/j.cub.2019.06.052
  • Yta7, a New Player in Saccharomyces Cerevisiae DNA Damage Response, , 51st Annual Meeting of the Canadian Society of Biochemistry and Molecular & Cellular Biology, 2008
  • S-nitrosation of disulfide-reduced oxytocin studied by mass spectrometry, , 87th Canadian Society for Chemistry Conference and Exhibition, 2004
  • The Identification of Nuclear FMRP Isoform Iso6 Partners, Rachid Mazroui, Jean-Philippe Lambert, Pauline Adjibade, Samer Hussein, Alexandre Simard, Emeline I. J. Lelong, Nassim Ledoux, Cells, 2023, 10.3390/cells12242807
  • Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation, Andrews, B., Fillingham, J., Gingras, A.-C., Rosebrock, A., Pawson, T., Friesen, H., Petschnigg, J., Lambert, J.-P., Kurat, C.F., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1414024111
  • Systematic proteomic study of the human acetylome components, , 13th International conference on Systems Biology, 2012
  • Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin, Filippakopoulos, P., Gingras, A.-C., Strahl, B.D., Samsonova, A., Schapira, M., Goding, C., Kanapin, A., Friedrichsen, H., Krajewski, K., Shanle, E.K., Wang, C.-Y., Picaud, S., Lambert, J.-P., Fujisawa, T., Krojer, T., Savitsky, P., Cell Reports, 2016, 10.1016/j.celrep.2016.11.014
  • A novel proteomics approach for the discovery of chromatinassociated protein networks, Figeys, D., Baetz, K., Rudner, A., Mitchell, L., Lambert, J.-P., Molecular and Cellular Proteomics, 2009, 10.1074/mcp.M800447-MCP200
  • Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila, Fillingham, J., Pearlman, R.E., Lambert, J.-P., Derynck, J., Garg, J., Saettone, A., Ashraf, K., Nabeel-Shah, S., Scientific Reports, 2020, 10.1038/s41598-019-56867-0
  • Functional interplay within the BET protein family impacts cell growth, , 8th Annual CNPN Symposium on proteomic advances in health and diseases, 2016
  • Functional proteomics characterization of the human acetyl lysine machinery, , The 3rd Canadian Conference on Epigenetics. Epigenomics in Development and Disease, 2016
  • SAINTq: Scoring protein-protein interactions in affinity purification – mass spectrometry experiments with fragment or peptide intensity data, Choi, H., Gingras, A.-C., Knight, J.D.R., Lambert, J.-P., Fermin, D., Koh, H., Teo, G., Proteomics, 2016, 10.1002/pmic.201500499
  • IRX3/5 regulate mitotic chromatid segregation and limb bud shape, Hopyan, S., Hui, C.-C., Gingras, A.-C., Kawakami, Y., Iulianella, A., Sun, Y., Henkelman, R.M., Garry, D.J., Anderson, G., Chen, X.X., Gong, W., Zhang, X., Puviindran, V., Sturgeon, K., Lau, K., Li, D., Hahn, N.A., Zhu, M., Yung, T.M., Lambert, J.-P., Tao, H., Development (Cambridge, England), 2020, 10.1242/dev.180042
  • Analysis of protein interaction networks using mass spectrometry compatible techniques, Figeys, D., Vasilescu, J., Lambert, J.-P., Ethier, M., Analytica Chimica Acta, 2006, 10.1016/j.aca.2005.12.046
  • Analysis of low-abundance proteins using the proteomic reactor with pH fractionation, Figeys, D., Tian, R., Lambert, J.-P., Hou, W., Zhou, H., Talanta, 2010, 10.1016/j.talanta.2009.07.018
  • Molecular dissection of the mode of resistance to BET bromomdomain inhibitors in melanoma, , 11th annual symposium of the Canadian National Proteomics Network, 2019
  • Large-Scale Proteomics Characterization of the Budding Yeast Chromatin by mChIP, , 8th annual world congress of the human proteome organization (HUPO), 2009
  • Functional proteomics characterization of epigenetics regulators involved in melanoma, , Melanoma: From Basic Science to Clinical Applications, 2015
  • Exploring the yeast acetylome using functional genomics, Andrews, B., Figeys, D., Chong, Y.T., Lambert, J.-P., Baryshnikova, A., Friesen, H., Kaluarachchi Duffy, S., Cell, 2012, 10.1016/j.cell.2012.02.064
  • A Novel Proteomic Approach to Chromatin Immunopurification Uncovers a Role for Yta7 in DNA Damage Response, , Chromatin Structure & Function 2007, 2007
  • Restriction of histone gene transcription to S phase by phosphorylation of a chromatin boundary protein, Andrews, B.J., Fillingham, J., Figeys, D., Nislow, C., Kainth, P., Friesen, H., Kaluarachchi, S., van Bakel, H., Tsui, K., van Dyk, D., Lambert, J.-P., Kurat, C.F., Genes and Development, 2011, 10.1101/gad.173427.111
  • BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma, Goding, C.R., Falletta, P., Larue, L., Masson, J.-Y., Gingras, A.-C., Middleton, M.R., Roberts, N.D., Chauhan, J., Andrews, S., Suer, E., Sarkar, S., Robles-Espinoza, C.D., Sesma-Sanz, L., Kalkavan, H., Louphrasitthiphol, P., Lambert, J.-P., Binet, R., Herbert, K., Genes and Development, 2019, 10.1101/gad.314633.118
  • Proteomics investigation of bromodomain functions within SWI/SNF complexes, , 23è journée scientifique des étudiants du CRC, 2019
  • The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation, Côté, J., Durocher, D., Doyon, Y., Legube, G., Pandita, T.K., Gingras, A.-C., Herst, P., Paquet, E., Pandita, R.K., Roques, C., Lambert, J.-P., Avvakumov, N., Fradet-Turcotte, A., Jacquet, K., Molecular Cell, 2016, 10.1016/j.molcel.2016.03.031

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Jenifer Espinoza Romero - Maîtrise avec mémoire - En cours
  • Ismaël Saïdi - Maîtrise avec mémoire - En cours
  • Naomie Linteau - Doctorat - En cours
  • Sophie Anne Blanchet - Doctorat - En cours
  • Quentin Vincent Gabriel Destombes - Doctorat - En cours
  • Pata-Eting Kougnassoukou Tchara - Doctorat - En cours
  • Lynda Marie Clemence Agbo - Doctorat - 2022/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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