Jean Sévigny

Tricyclic coumarin sulphonate derivatives with alkaline phosphatase inhibitory effects: in vitro and docking studies, Oh, CH, Sevigny, J, Lecka, J, Ejaz, SA, El-Gamal, MI, Iqbal, J, Journal of enzyme inhibition and medicinal chemistry, 2018, 10.1080/14756366.2018.1428193

Synthesis, characterization, in vitro tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) inhibition studies and computational evaluation of novel thiazole derivatives, Iqbal, J, Sevigny, J, Pelletier, J, Shafiq, Z, Saeed, A, Zaib, S, Mahmood, A, Aziz, H, Bioorganic chemistry, 2020, 10.1016/j.bioorg.2020.104088

Structural elements and limited proteolysis of CD39 influence ATP diphosphohydrolase activity, Robson, SC, Beaudoin, AR, Koziak, K, Imai, M, Siegel, JB, Kaczmarek, E, Sévigny, J, Schulte am Esch, J, Biochemistry, 1999, 10.1021/bi982426k

Homocysteine modifies extracellular ATP availability in macrophages, Oliveira Battastini, Ana Maria, de Souza Wyse, Angela Terezinha, Sevigny, Jean, Braganhol, Elizandra, Bergamin, Leticia Scussel, Zanin, Rafael Fernandes, Toxicology in Vitro, 2013, 10.1016/J.TIV.2013.09.001

1. Role d'un HTF dans la replication. 2. Role de c-myc dans la recombinaison, Sevigny, Jean, 1992

Generation and characterization of a monoclonal antibody as the first specific inhibitor of human NTPDase3, Sevigny, J., Kirley, T. L., Kuenzli, B., Tremblay, A., Pelletier, J., Ivanenkov, V. V., Fausther, M., Munkonda, M. N., 2010

Synthesis and computational studies of highly selective inhibitors of human recombinant tissue non-specific alkaline phosphatase (h-TNAP): A therapeutic target against vascular calcification, Hameed, S, Iqbal, J, Zhang, J, Yasinzai, M, Farman, M, Sevigny, J, Abida Ejaz, S, Hussain, M, Andleeb, H, Bioorganic chemistry, 2020, 10.1016/j.bioorg.2020.103999

Inhibition of ATPDase/CD30 in human vascular endothelial cells by antisense oligonucleotides, Sévigny, Jean, 1999

Atp-diphosphohydrolases, process of purification thereof and process of producing thereof by recombinant technology, Beaudoin Adrien, R., Jean Sévigny, 1996

CD39/vascular ATP diphosphohydrolase modulates xenograft survival, Robson, SC, Rosenberg, RD, Bach, FH, Enjyoji, K, Goepfert, C, Kaczmarek, E, Sevigny, J, Lin, Y, Guckelberger, O, Takigami, K, Imai, M, Transplantation proceedings, 2000, 10.1016/s0041-1345(00)01065-4

Neutrophils: fast and furious-the nucleotide pathway, Braganhol, E, Sevigny, J, Lenz, GS, Omizzollo, N, de Souza, PO, Rubenich, DS, Purinergic signalling, 2021, 10.1007/s11302-021-09786-7

Extracellular ectonucleotidases are differentially regulated in murine tissues and human polymorphonuclear leukocytes during sepsis and inflammation, Haskó, G, Braganhol, E, Németh, Z, Sévigny, J, Leite, RO, Pelletier, J, de Souza, PO, Pacher, P, Lovászi, M, Haas, CB, Purinergic signalling, 2021, 10.1007/s11302-021-09819-1

Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonists, Jacobson, K. A., Iqbal, J., Sévigny, J., Pelletier, J., Gopinatth, V., Pramanik, A., Lewicki, S. A., Shah, Q., Jung, Y. H., Bioorganic & medicinal chemistry letters, 2022, 10.1016/j.bmcl.2022.128981

Localization of nucleoside triphosphate diphosphohydrolase-1 (NTPDase1) and NTPDase2 in pancreas and salivary gland, Sévigny, J, Robson, SC, Braun, N, Kordás, K, Guckelberger, O, Bigonnesse, F, Pelletier, J, Kittel, A, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2004, 10.1369/jhc.3A6167.2004

2-Alkoxy-3-(sulfonylarylaminomethylene)-chroman-4-ones as potent and selective inhibitors of ectonucleotidases, Iqbal, J, Hameed, A, Sevigny, J, Lecka, J, Khan, S, Ejaz, SA, Sattar, A, Batool, G, Al-Rashida, M, European journal of medicinal chemistry, 2016, 10.1016/j.ejmech.2016.02.073

Identification of thienopyrimidine glycinates as selective inhibitors for h-NTPDases, Abbas Hassan, Jamshed Iqbal, Jean Sévigny, Julie Pelletier, Ahsanullah, Farman Ullah, Muhammad Uzair, Muhammad Akram, Saif Ullah, Zahra Begum, Bioorganic Chemistry, 2022, 10.1016/j.bioorg.2022.106196

Endothelial P2Y(2) receptor regulates LPS-induced neutrophil transendothelial migration in vitro, Sevigny, Jean, Tremblay, Alain, Fausther, Michel, Bahrami, Fariborz, Ben Yebdri, Fethia, Kukulski, Filip, Molecular Immunology, 2010, 10.1016/J.MOLIMM.2009.11.020

Identification of hydrolytically stable and selective P2Y(1) receptor agonists, Fischer, Bilha, Gelinas, Sylvie, Sevigny, Jean, Weisman, Gary A., Lecka, Joanna, Camden, Jean, Elyahu, Shay, 2008

Altered lipid and salt taste responsivity in ghrelin and GOAT null mice, Maudsley, S, Martin, B, Sevigny, J, Tschop, MH, Wang, R, Daimon, CM, Cong, WN, Cai, H, PloS one, 2013, 10.1371/journal.pone.0076553

Canalicular ecto-ATPase is a novel member of the GDA 1/CD39 NTPase family., Sévigny, Jean, 1999

Epidermal melanocytes metabolize extracellular nucleotides by purinergic enzymes, Marcia Wink, Silvya Stuchi Maria-Engler, Tiago Franco de Oliveira, Jean Sévigny, Jéssica Gonçalves Azevedo, Liliana Sous Naasani, Biochemistry and Cell Biology, 2023, 10.1139/bcb-2022-0058

Ectonucleotidases in the digestive system: focus on NTPDase3 localization, Sevigny, J, Sharkey, KA, Aliagas, E, Martin-Satue, M, Gulbransen, BD, Lavoie, EG, American journal of physiology Gastrointestinal and liver physiology, 2011, 10.1152/ajpgi.00207.2010

New one-pot synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C-H arylation: potent inhibitors of nucleotide pyrophosphatase-1 and -3, Langer, P, Iqbal, J, Sevigny, J, Lecka, J, Villinger, A, Ehlers, P, Khan, SU, Ejaz, SA, Ausekle, E, Organic & biomolecular chemistry, 2016, 10.1039/c6ob02236g

Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants, Soares, MP, Bach, FH, Choi, AM, Vercellotti, G, Robson, SC, Sevigny, J, Csizmadia, E, Lin, Y, Brouard, S, Smith, RN, Otterbein, L, Balla, J, Sato, K, The Journal of Immunology, 2001, 10.4049/JIMMUNOL.166.6.4185

Purine-metabolizing ectoenzymes control IL-8 production in human colon HT-29 cells, Sevigny, J, Rockenbach, L, Pelletier, J, Tremblay, A, Lecka, J, Kukulski, F, Bahrami, F, Mediators of inflammation, 2014, 10.1155/2014/879895

Synthesis, characterization and biological evaluation of N-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)benzamides, Iqbal, J, Sevigny, J, Lecka, J, Latif, M, al-Rashida, M, Hassan, S, Khurshid, A, Ejaz, SA, Saeed, A, RSC advances, 2015

Mammalian ATP-diphosphohydrolases and process of purification thereof, Robson, Simon, Bach Fitz, H., Beaudoin Adrien, R., Jean Sévigny, 2001

Sulfonylhydrazones: Design, synthesis and investigation of ectonucleotidase (ALP & e5'NT) inhibition activities, Al-Rashida, M, Iqbal, J, Sevigny, J, Pelletier, J, Mohamad, H, Asari, A, Batool, F, Saeed, M, Khan, MS, Mahmood, A, Hameed, A, Younus, HA, Bioorganic chemistry, 2020, 10.1016/j.bioorg.2020.103827

Identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors, Bajorath, J, Sevigny, J, Lecka, J, Furtmann, N, Hameed, A, Matin, A, Raza, R, Saeed, A, Iqbal, J, European journal of medicinal chemistry, 2013, 10.1016/j.ejmech.2013.10.053

Assignment of ecto-nucleoside triphosphate diphosphohydrolase-1/cd39 expression to microglia and vasculature of the brain, Zimmermann, H, Di Virgilio, F, Hammer, K, Guckelberger, O, Enjyoji, K, Robson, SC, Sévigny, J, Braun, N, The European journal of neuroscience, 2000

Mutagenesis of N-glycosylation sites of human ecto-ATPase (E-NTPDase 2), Knowles, A. F., Sevigny, J., Shindo, K., 2004

Vascular ATP diphosphohydrolase (CD39/ATPDase), Robson, S. C., Bach, F. H., Beaudoin, A., Hancock, W. W., Koziak, K., Sevigny, J., Siegel, J. B., Kaczmarek, E., Ecto-ATPases : recent progress on structure and function : [proceedings of the First International workshop on ecto-ATPases, held August 26-30, 1996, in Mar de Plata, Argentina], 1997, 10.1007/978-1-4615-5955-9_22

TREATMENT OF INFLAMMATORY BOWEL DISEASE WITH NUCLEOSIDE TRIPHOSPHATE DISPHOSHOHYDROLASE, P2Y2 ANTAGONIST AND/OR P2Y6 ANTAGONIST, Salem, Mabrouka, Jean Sévigny, 2018

Characterization of ecto-nucleotidases in human oviducts with an improved approach simultaneously identifying protein expression and in situ enzyme activity, Martin-Satue, M, Matias-Guiu, X, Sevigny, J, a, I, Gomez de Ar, Vidal, A, Trapero, C, Rodriguez-Martinez, A, Torrejon-Escribano, B, Villamonte, ML, Histochemistry and cell biology, 2018, 10.1007/s00418-017-1627-8

Synthesis and biological evaluation of sulfamate derivatives as inhibitors of carbonic anhydrases II and IX, Mohammed El-Gamal, Jamshed Iqbal, Taleb H. Al-Tel, Jean Sévigny, Julie Pelletier, Bilal O. AlKubaisi, Afnan I. Shahin, Rawan M. Sbenati, Seyed-Omar Zaraei, Saif Ullah, Saquib Jalil, Medicinal Chemistry Research, 2023, 10.1007/s00044-023-03043-9

The ectonucleotidase NTPDase1 controls IL-8 production by human neutrophils, Sevigny, Jean, Levesque, Sebstien, Martin-Satue, Mireia, Lecka, Joanna, Ben Yebdri, Fethia, Bahrami, Fariborz, Kukulski, Filip, 2010

P21(Waf1/Cip1) in endothelial cell survival, Sévigny, J, Aoudjit, F, Cardiovascular research, 2004, 10.1016/j.cardiores.2004.01.003

Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo, Sevigny, J, Tessier, PA, Warny, M, Lefebvre, J, Ben Yebdri, F, Kukulski, F, Journal of leukocyte biology, 2007, 10.1189/jlb.1206758

The nucleotide triphosphate dihydrolases CD39 and CD39L1 are expressed in distinct compartments within the rat liver, Sevigny, J., Robson, S. C., Kruglov, E., Dranoff, J. A., 2001, 10.1016/S0016-5085(08)80449-0

Involvement of purinergic system in the release of cytokines by macrophages exposed to glioma-conditioned medium, Battastini, AM, Sevigny, J, Zanin, RF, Casali, E, Figueiro, F, Braganhol, E, Bergamin, LS, Journal of cellular biochemistry, 2015, 10.1002/jcb.25018

Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3, Muller, CE, Fiene, A, Sevigny, J, Pelletier, J, Malik, EM, Schakel, L, Rashed, M, Baqi, Y, Frontiers in pharmacology, 2020, 10.3389/fphar.2020.01282

Characterization of soluble CD39 (SolCD39/NTPDase1) from PiggyBac nonviral system as a tool to control the nucleotides level, Wink, MR, Lenz, G, Sevigny, J, Bertoni, APS, Fontoura, DM, Onzi, GR, Iser, IC, Beckenkamp, LR, The Biochemical journal, 2019, 10.1042/BCJ20190040

Synthesis of 2-arylated thiadiazolopyrimidones by Suzuki–Miyaura cross-coupling: a new class of nucleotide pyrophosphatase (NPPs) inhibitors, Langer, P, Iqbal, J, Ehlers, P, Rahman, Q, Sévigny, J, Lecka, J, Safarov, S, Kalugin, SN, Turmukhanova, MZ, Abilov, ZA, Khan, SU, Afzal, S, Ejaz, SA, Ospanov, M, Yelibayeva, N, Jafari, B, RSC advances, 2016, 10.1039/c6ra22750c

Identification of the long-known canalicular ecto-ATPase as the novel ecto-nucleotidase NTPDase8, Sevigny, J., Dranoff, J., Pelletier, J., Levesque, S. A., Lecka, J., Fausther, M., 2005

Efficient one-pot synthesis of 5-perfluoroalkylpyrazoles by cyclization of hydrazone dianions, Langer, P, Sevigny, J, Lecka, J, Iqbal, J, Dang, TT, Hung, TQ, Ejaz, SA, Ngo, TN, Organic & biomolecular chemistry, 2015, 10.1039/c5ob01151e

Effect of P2 receptor antagonists and potential inhibitors on plasma membrane NTPDases., Sevigny, J., Lecka, J., Legendre, C., Levesque, S. A., 2005

Cochlear distribution of NTPDase1 and 2., Housley, Gary D., Robson, Simon C., Sevigny, Jean, Thorne, Peter R., Vlajkovic, Srdjan M., 2002

Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists, Sevigny, J, Lecka, J, Lavoie, EG, Pelletier, J, Legendre, C, Levesque, SA, Kukulski, F, Kauffenstein, G, Munkonda, MN, Biochemical pharmacology, 2007, 10.1016/j.bcp.2007.07.033

Characterization of a novel E-NTPDase, Lemmens, R., Csizmadia, E., Beaudoin, A. R., Robson, S. C., Sévigny, J., Ecto-ATPases and related ectonucleotidases : proceedings of the Second International Workshop on Ecto-ATPases and Related Ecotonucleotidases, held in Diepenbeek, Belgium, June 14-18, 1999, 1999

2-Hexylthio-β,γ-CH2-ATP is an effective and selective NTPDase2 inhibitor, Fischer, B, Sevigny, J, Senderowitz, H, Martin-Satue, M, Fausther, M, Munkonda, MN, Simhaev, L, Lecka, J, Gillerman, I, Journal of medicinal chemistry, 2014, 10.1021/jm401933c

Concomitant activation of P2Y(2) and P2Y(6) receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion, Sevigny, Jean, Tremblay, Alain, Kukulski, Filip, Ben Yebdri, Fethia, European Journal of Immunology, 2009, 10.1002/EJI.200939347

Blockade of P2Y receptors prevents cirrhosis due to carbon tetrachloride but not extrahepatic bile duct ligation, Sevigny, J, Robson, S, Kruglov, EA, Dranoff, JA, The FASEB Journal, 2004

Extracellular ATP Selectively Upregulates Ecto-Nucleoside Triphosphate Diphosphohydrolase 2 and Ecto-5'-Nucleotidase by Rat Cortical Astrocytes In Vitro, Nedeljkovic, N, Kipp, M, Sevigny, J, Bjelobaba, I, Lavrnja, I, Milosevic, M, Parabucki, A, Laketa, D, Adzic, M, Brisevac, D, Journal of molecular neuroscience : MN, 2015, 10.1007/s12031-015-0601-y

Homeostasis of extracellular ATP in uninfected RBCs from a Plasmodium falciparum culture and derived microparticles, Schwarzbaum, PJ, Ostuni, MA, Lauri, N, Denis, MFL, Sévigny, J, Hattab, C, Fader, CM, Lapouméroulie, C, Gamain, B, Semblat, JP, Chêne, A, Alvarez, CL, Biochimica et biophysica acta Biomembranes, 2022, 10.1016/j.bbamem.2022.183980

Investigation of new quinoline derivatives as promising inhibitors of NTPDases: Synthesis, SAR analysis and molecular docking studies, Hassan, A, Iqbal, J, Sevigny, J, Lecka, J, Zaib, S, Khan, KM, Ur Rahman, S, Murtaza, A, Saeed, A, Afzal, S, Hayat, K, Bioorganic chemistry, 2019, 10.1016/j.bioorg.2019.03.019

RPE cells express both NTPDasel and NTPDase2: resulting ADP can increase cell calcium, Mitchell, C. H., Stone, R. A., Laties, A. M., Sevigny, J., McGlinn, A., Pendrak, K., Reigada, D., Lu, W., 2004

A Simple and Efficient Genetic Immunization Protocol for the Production of Highly Specific Polyclonal and Monoclonal Antibodies against the Native Form of Mammalian Proteins, Sevigny, J, Babou Kammoe, RB, Luyindula, P, Salem, M, G Lavoie, E, Manica, F, Agonsanou, H, Pelletier, J, International journal of molecular sciences, 2020, 10.3390/ijms21197074

ATP diphosphohydrolase (CD39) gene therapy for inflammatory or thrombotic conditions and transplantation and means there for, Beaudoin Adrien, R., Robson, Simon, Jean Sévigny, Bach Fritz, H., 2006

Concentrates of two subsets of extracellular vesicles from cow's milk modulate symptoms and inflammation in experimental colitis, Provost, P, Sevigny, J, Gilbert, C, Michel, S, Salem, M, Diallo, I, Benmoussa, A, Scientific reports, 2019, 10.1038/s41598-019-51092-1

Expression of the ecto-ATPase NTPDase2 in the germinal zones of the developing and adult rat brain, Zimmermann, H, Hammer, K, Gerstberger, R, Barth, SW, Robson, SC, Mishra, SK, Sevigny, J, Braun, N, The European journal of neuroscience, 2003, 10.1046/j.1460-9568.2003.02567.x

Ticlopidine in its prodrug form is a selective inhibitor of human NTPDase1, Sevigny, J, Kunzli, B, Fausther, M, Lecka, J, Mediators of inflammation, 2014, 10.1155/2014/547480

A domino reaction of 3-chlorochromones with aminoheterocycles. Synthesis of pyrazolopyridines and benzofuropyridines and their optical and ecto-5'-nucleotidase inhibitory effects, Langer, P, Lochbrunner, S, Friedrich, A, Villinger, A, Sevigny, J, Lecka, J, Iqbal, J, Zaib, S, Hassan, S, Janke, J, Miliutina, M, Organic & biomolecular chemistry, 2018, 10.1039/c7ob02729j

Regional and sex-related differences in modulating effects of female sex steroids on ecto-5'-nucleotidase expression in the rat cerebral cortex and hippocampus, Grkovic, I, Nedeljkovic, N, Horvat, A, Sevigny, J, Zlatkovic, J, Stanojlovic, M, Drakulic, D, Gusevac, I, Mitrovic, N, General and comparative endocrinology, 2016, 10.1016/j.ygcen.2016.06.018

Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response, Schrader, J, Gödecke, A, Zimmermann, H, Ley, K, Ding, Z, Weber, C, Molojavyi, A, Weber, AA, Gear, A, Sevigny, J, Smith, ML, Decking, UK, Buchheiser, A, Braun, N, Flögel, U, Zernecke, A, Huo, Y, Ozüyaman, B, Koszalka, P, Circulation research, 2004, 10.1161/01.RES.0000144796.82787.6f

Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme., Battastini AMO, Figueiró F, Sévigny J, Campos JM, Conejo-García A, Cruz-López O, Morrone FB, Weber AF, de Fraga Dias A, Scholl JN, da Silva ÁC, Purinergic signalling, 2023, 10.1007/s11302-023-09975-6

Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors, Langer, P, Iqbal, J, Spannenberg, A, Ehlers, P, Sevigny, J, Lecka, J, Khan, SU, Afzal, S, Ejaz, SA, Kuhrt, D, European journal of medicinal chemistry, 2017, 10.1016/j.ejmech.2017.07.017

Editorial: Metalloenzymes: Potential Drug Targets, Sévigny, J, Jacob, C, Iqbal, J, Frontiers in pharmacology, 2021, 10.3389/fphar.2021.746925

A highly sensitive capillary electrophoresis method using p-nitrophenyl 5'-thymidine monophosphate as a substrate for the monitoring of nucleotide pyrophosphatase/phosphodiesterase activities, Muller, CE, Sevigny, J, Levesque, SA, Lee, SY, Journal of chromatography B, Analytical technologies in the biomedical and life sciences, 2012, 10.1016/j.jchromb.2012.10.044

Differential macrophage activation alters the expression profile of NTPDase and ecto-5'-nucleotidase, Battastini, AM, de Souza Wyse, AT, Schetinger, MR, Sevigny, J, Morrone, FB, Moreira, JC, Filho, AZ, Campesato, LF, Bergamin, LS, Braganhol, E, Zanin, RF, PloS one, 2012, 10.1371/journal.pone.0031205

Benzo[b]carbazolediones Synthesis and Inhibitory Effects on Nucleotide Pyrophosphatases/Phosphodiesterases, Langer, P, Ehlers, P, Iqbal, J, Sévigny, J, Lecka, J, Khan, SU, Villinger, A, Ohlendorf, L, Molenda, R, Ejaz, SA, Do, HH, ChemistrySelect, 2019, 10.1002/slct.201803061

The bovine aorta ATP-diphosphohydrolase, an ectoenzyme involved in the hydrolysis of P-2-purinoceptor agonists, Sévigny, Jean, 1995

Erratum: Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8. (Purinergic Signalling (2005) vol. 1 (2) (193-204)), Sevigny, J., Kirley, T. L., Robson, S. C., Knowles, A. F., Bigonnesse, F., Lecka, J., Lavoie, E. G., Levesque, S. A., Kukulski, F., Purinergic Signalling, 2005

Essential role of P2Y6 receptor in vascular contraction-lessons from P2Y6 knockout mice, Henrion, Daniel, Robaye, Bernard, Sevigny, Jean, Loufrani, Laurent, Kauffenstein, Gilles, 2010

Analysis of CD39/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytes, Kaczmarek, E, Siegel, JB, Robson, SC, Sévigny, J, Koziak, K, Thrombosis and haemostasis, 1999

Resistance training reduces platelet activation in hypertensive women: the role of purinergic signaling, Clodoaldo Antônio De Sá, Vanessa da Silva Corralo, Jean Sévigny, Sarah Franco Vieira de Oliveira Maciel, Daniela Zanini, Aline Mânica, Mônica Lammers, Nyasmin Mendes Aneli, Andréia Machado Cardoso, Journal of Hypertension, 2023, 10.1097/hjh.0000000000003529

NTPDase1 controls IL-8 production by human neutrophils, Sevigny, J, Levesque, SA, Martin-Satue, M, Lecka, J, Ben Yebdri, F, Bahrami, F, Kukulski, F, Journal of immunology (Baltimore, Md : 1950), 2011, 10.4049/jimmunol.1002680

Synthesis of new sulphonate derivatives containing adamantane and 4-chlorophenyl moieties as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors, Jamshed Iqbal, Peter Langer, Abdul Rehman Khan, Jean Sévigny, Julie Pelletier, Amna Batool, Kiran Hamid, Saif Ullah, Journal of Molecular Structure, 2023, 10.1016/j.molstruc.2022.134494

Extracellular nucleotides mediate LPS -induced IL -8 release from monocytes and neutrophil migration., Sévigny, Jean, Lvesque, Sbastien, Lefebvre, Julie, Yebdri, Fethia Ben, Kukulski, Filip, 2006, 10.1096/fasebj.20.4.a203-be

Adenine-(methoxy)-ethoxy-P-dithio-triphosphate inhibits pathologic calcium pyrophosphate deposition in osteoarthritic human chondrocytes, Fischer, B, Muller, CE, Sevigny, J, Pelletier, J, Zimmermann, H, Renn, C, Yaw Attah, I, Rafehi, M, Lee, S, Arad, U, Mirza, S, Nassir, M, Organic & biomolecular chemistry, 2019, 10.1039/c9ob02199j

NTPDASE1 (CD39) regulates extracellular nuclecitides-induced vasomotion, Sevigny, J., Kauffenstein, G., 2007

Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury, Battastini, AM, Robson, SC, Sevigny, J, Wink, MR, Edelweiss, MI, Calixto, JB, Campos, MM, Morrone, FB, Campesato, LF, Cappellari, AR, Bergamin, LS, Bernardi, A, Zanin, RF, Braganhol, E, Purinergic signalling, 2012, 10.1007/s11302-011-9276-1

IL-6 transcriptionally downregulates portal fibroblast Ntpdase2 expression via specific promoter elements, Dranoff, Jonathan A., Sevigny, Jean, Sheung, Nina, Lavoie, elise, Yu, Jin, 2007

Stimulation of the P2Y1 receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells, Mitchell, CH, Sevigny, J, Reigada, D, Lu, W, The Journal of pharmacology and experimental therapeutics, 2007, 10.1124/jpet.107.124545

Functional expression of the ecto-ATPase NTPDase2 and of nucleotide receptors by neuronal progenitor cells in the adult murine hippocampus, Braun, N, Robson, SC, Sévigny, J, Hammer, K, Raab, S, Kettenmann, H, Wang, L, Zimmermann, H, Shukla, V, Journal of neuroscience research, 2005, 10.1002/jnr.20508

Cochlear distribution of NTPDase1 and 2, Housley, GD, Robson, SC, Sevigny, J, Thorne, PR, Vlaikovic, SM, Drug Development Research, 2002

Role of Nucleotides, Ectonucleotidases and P2 Receptors in Vascular Contraction and Myogenic Tone, Henrion, D., Sevigny, J., Robaye, B., Thorin, E., Loufrani, L., Drouin, A., Kauffenstein, G., 2010

Synthesis, characterization and biological evaluation of thiadiazole amide derivatives as nucleoside triphosphate diphosphohydrolases (NTPDases) inhibitors, Iqbal, J, Ashraf, Z, Sévigny, J, Langer, P, Hussain, D, Nadeem, H, Afzal, S, Abbas, S, Bioorganic chemistry, 2022, 10.1016/j.bioorg.2021.105456

3-(5-(Benzylideneamino)thiazol-3-yl)-2Hchromen-2-ones: a new class of alkaline phosphatase and ecto-5'-nucleotidase inhibitors, Iqbal, J, Sévigny, J, Lecka, J, al-Rashida, M, Hassan, S, Shehzad, M, Ejaz, SA, Saeed, A, RSC advances, 2016

Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes, Hanif, M, Hartinger, CG, Iqbal, J, Asiri, AM, Zayed, MEM, Sevigny, J, Lecka, J, Arshad, MN, Siddiqui, WA, Rahman, SU, Ejaz, SA, Ashraf, A, European journal of medicinal chemistry, 2018, 10.1016/j.ejmech.2018.09.063

NTPDase1/CD39 Ectonucleotidase Is Necessary for Normal Arterial Diameter Adaptation to Flow, Gilles Kauffenstein, Daniel Henrion, Jean Sévigny, Eric Thorin, Simon C. Robson, Marc-Antoine Gillis, Manon Laprise, Annick Drouin, Anne-Laure Guihot, Charlotte Roy, Julie Favre, International Journal of Molecular Sciences, 2023, 10.3390/ijms242015038

The anti-inflammatory effect of resistance training in hypertensive women: the role of purinergic signaling, Cardoso, AM, Manfredi, LH, De Sa, CA, Sevigny, J, Bagatini, MD, de Resende E Silva, DT, Manica, A, Zanini, D, de Oliveira Maciel, SFV, de Oliveira, GG, Aneli, NM, Lammers, MD, Journal of hypertension, 2020, 10.1097/HJH.0000000000002578

Highly Potent and Selective Ectonucleoside Triphosphate Diphosphohydrolase (ENTPDase1, 2, 3 and 8) Inhibitors Having 2-substituted-7- trifluoromethyl-thiadiazolopyrimidones Scaffold, Iqbal, J, Lecka, J, Sevigny, J, Langer, P, Jafari, B, Zaib, S, Afzal, S, Medicinal chemistry (Shariqah (United Arab Emirates)), 2020, 10.2174/1573406415666190614095821

Synthesis and characterization of nucleotide mimetics as inhibitors of ecto-5 '-nucleotidase (CD73) and NTPDase1 (CD39), Mueller, C. E., Zimmermann, H., Sevigny, J., Munkonda, M. N., Lee, S. Y., Iqbal, J., Brunschweiger, A., 2008

Extracellular ATP hydrolysis in Caco-2 human intestinal cell line, Schwarzbaum, PJ, Ostuni, MA, Sévigny, J, Molineris, MP, Gonzalez-Lebrero, R, Rinaldi, DE, Hattab, C, Corradi, G, Faillace, MP, Bazzi, Z, Alvarez, CL, Schachter, J, Biochimica et biophysica acta Biomembranes, 2021, 10.1016/j.bbamem.2021.183679

CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 maintains vascular integrity in intestinal ischemia-reperfusion injury., Robson, S. C., Kaczmarek, E., Enjyoji, K., Imai, M., Sevigny, J., Sun, X. F., Guckelberger, O., 2004

Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach, Braganhol, E, Teixeira, HF, Battastini, AMO, Stefani, MA, Sevigny, J, Wink, MR, daCosta, JC, Greggio, S, Venturin, G, de Oliveira, FH, Lenz, GS, Iser, IC, Beckenkamp, LR, Gelsleichter, NE, Michels, LR, Schuh, RS, Azambuja, JH, Molecular neurobiology, 2020, 10.1007/s12035-019-01730-6

CD39 ist ein kritischer Modulator der Thrombozytenund Endothelzellaktivierung nach Ischämie-Reperfusion, S. C. Robson, P. Neuhaus, E. Kaczmarek, K. Enjyoji, J. B. Kruskal, M. Imai, J. Sévigny, O. Guckelberger, Deutsche Gesellschaft für Chirurgie, 2001, 10.1007/978-3-642-56698-1_79

Physical exercise prevents alterations in purinergic system and oxidative status in lipopolysaccharide-induced sepsis in rats, Cardoso, AM, Schetinger, MRC, Morsch, VM, Sevigny, J, da Cruz, IBM, Lopes, TF, da Silva, AD, Reichert, KP, Pelinson, LP, da Costa, P, Stefanello, N, Assmann, CE, Bottari, NB, Miron, VV, Journal of cellular biochemistry, 2019, 10.1002/jcb.27590

Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism, Perez-Matos, MC, Jiang, ZG, Robson, SC, Maratos-Flier, E, Sévigny, J, Enjyoji, K, Tiwari-Heckler, S, Csizmadia, E, Huang, J, Yalcin, Y, Mitsuhashi, S, Pelletier, J, Feldbrügge, L, Syed, I, Singhal, G, Tran, S, hu, B, S, Metabolism: clinical and experimental, 2021, 10.1016/j.metabol.2021.154731

Identification and isolation of a novel liver cell type expressing the ecto-nucleotidase NTPDase 2, Zimmerman, H., Braun, N., Robson, S. C., Sevigny, J., Kruglov, E. A., Dranoff, J. A., 2002

The endothelial P2Y2 receptor mediates LPS-induced neutrophil transendothelial migration, Sevigny, Jean, Tremblay, Alain, Fausther, Michel, Ben Yebdri, Fethia, Kukulski, Filip, 2008

METHOD OF REDUCING ANGIOGENESIS, Hoshi, Tomokazu, Sundberg, Christian, Robson Simon, C., Jean Sévigny, 2003

Synthesis, characterization, alkaline phosphatase inhibition assay and molecular modeling studies of 1-benzylidene-2-(4-tert- butylthiazol-2-yl) hydrazines, Iqbal, J, Sévigny, J, Pelletier, J, El-Seedi, HR, Saeed, A, Zaib, S, Mahmood, A, Aziz, H, Journal of biomolecular structure & dynamics, 2021, 10.1080/07391102.2020.1802336

Localization and role of ecto-5'-nucleotidase (CD73) in the basal ganglia - Relation to adenosine A2A receptors, Chen, J. F., Cunha, R. A., Sevigny, J., Matos, M., Augusto, E., 2012

Purification, characterization, and localization of two ATP diphosphohydrolase isoforms in bovine heart, Levesque, FP, Daoud, S, Grondin, G, Sévigny, J, Beaudoin, AR, The American journal of physiology, 1997, 10.1152/ajpheart.1997.273.2.H673

Disordered cellular migration and angiogenesis in cd39-null mice, Robson, S, Csizmadia, E, Hoshi, T, Enjyoji, K, Sévigny, J, Sundberg, C, Goepfert, C, Circulation, 2001, 10.1161/hc5001.100663

Nucleoside triphosphate diphosphohydrolase-1 ectonucleotidase is required for normal vas deferens contraction and male fertility through maintaining P2X1 receptor function, Sevigny, J, Vial, C, Sullivan, R, Henrion, D, Toutain, B, Sereda, MJ, Ribas Furstenau, C, Frenette, J, Dufresne, SS, Martin-Satue, M, Kukulski, F, Lavoie, EG, Pelletier, J, Kauffenstein, G, The Journal of biological chemistry, 2014, 10.1074/jbc.M114.604082

NUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE (NTPDASE 8) AND USES THEREOF, Jean Sévigny, 2004

Synthesis and structure–activity relationships of ticlopidine derivatives and analogs as inhibitors of ectonucleotidase CD39, Christa E. Müller, Jean Sévigny, Thanigaimalai Pillaiyar, Sang-Yong Lee, Julie Pelletier, Katharina Sylvester, Salahuddin Mirza, Laura Schäkel, Chunyang Bi, Bioorganic Chemistry, 2023, 10.1016/j.bioorg.2023.106460

Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors., Iqbal J, Shafiq Z, Negm S, Taslimi P, El-Kott AF, Al-Harrasi A, Ajmal M, Hussain Z, Sévigny J, Pelletier J, Tasleem M, International journal of biological macromolecules, 2024, 10.1016/j.ijbiomac.2024.131068

Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents, El-Gamal, MI, Iqbal, J, Sevigny, J, Pelletier, J, Zaib, S, Al-Rashida, M, Zaraei, SO, Ullah, S, El-Gamal, R, Anbar, HS, Bioorganic chemistry, 2020, 10.1016/j.bioorg.2020.104305

Cloning of the hepatic canalicular ecto-atpase: Identification as a novel nucleoside triphosphate diphosphohydrolase., Sévigny, Jean, 2002

Modulation of extracellular nucleotide-mediated signaling by CD39/nucleoside triphosphate diphosphohydrolase-1, Warny, M, Sévigny, J, Lin, Y, Kaczmarek, E, Imai, M, Goepfert, C, Enjyoji, K, Robson, SC, Drug development research, 2001, 10.1002/ddr.1188

Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes, Fischer, B, Muller, CE, Sevigny, J, Pelletier, J, Zimmermann, H, Renn, C, Mirza, S, Journo, S, Lee, SY, Arad, U, Nassir, M, Purinergic signalling, 2019, 10.1007/s11302-019-09649-2

Extracellular nucleotides and ectonucleotidases control IL-8 production in human colon HT-29 cells, Sevigny, Jean, Pelletier, Julie, Lecka, Joanna, Kukulski, Filp, Bahrami, Fariborz, 2010

Localization of plasma membrane bound NTPDases in the murine reproductive tract, Sevigny, J, Robson, SC, Guckelberger, O, Csizmadia, E, Fausther, M, Pelletier, J, Lavoie, EG, Martin-Satue, M, Histochemistry and cell biology, 2009, 10.1007/s00418-008-0551-3

Characterization and mutagenesis of CD39/vascular ATP diphosphohydrolase, Sévigny, Jean, 1997

Identification of Potent and Selective Human Ecto-Nucleotide Pyrophos- phatase/Phosphodiesterase-3 (hNPP3) Inhibitors, Sévigny, J, Iqbal, J, Lecka, J, Hameed, S, Akhtar, T, Raza, R, Open Enzyme Inhibition Journal, 2011

P2Y2 receptor transcription is increased by NF-kappa B and stimulates cyclooxygenase-2 expression and PGE2 released by intestinal epithelial cells, Gendron, FP, Sevigny, J, Weisman, GA, Jain, N, Langlois, C, Lavoie, EG, Dupuis, AA, Grbic, DM, Degagne, E, Journal of immunology (Baltimore, Md : 1950), 2009, 10.4049/jimmunol.0803977

Establishment and characterization of rat portal myofibroblast cell lines, Dranoff, JA, Sevigny, J, Graham, AL, Lavoie, EG, Goree, JR, Fausther, M, PloS one, 2015, 10.1371/journal.pone.0121161

Supplement comprising of laccase and citric acid as an alternative for antibiotics: In vitro triggers of melanin production, Avalos-Ramirez, A, Sévigny, J, ez-Galan, L, Hern, Brar, SK, Salem, M, Suresh, G, Lecka, J, Chaali, M, Engineering in life sciences, 2018, 10.1002/elsc.201700160

IL-6 downregulates transcription of NTPDase2 via specific promoter elements, Dranoff, JA, Sevigny, J, Tremblay, JJ, Sheung, N, Lavoie, EG, Yu, J, American journal of physiology Gastrointestinal and liver physiology, 2008, 10.1152/ajpgi.00208.2007

NTPDase2 is necessary for regulation of bile duct epithelial proliferation by portal fibroblasts, Sevigny, Jean, Kruglov, Emma A., ier, Muhammad N., Jh, Dranoff, Jonathan A., 2004

CD73 Downregulation Decreases In Vitro and In Vivo Glioblastoma Growth, Braganhol, E, Teixeira, HF, Stefani, MA, Wink, MR, Sevigny, J, Spanevello, RM, de Oliveira, FH, Scholl, JN, Battastini, AMO, Figueiro, F, es, MC, Fern, Iser, IC, Beckenkamp, LR, Gelsleichter, NE, Azambuja, JH, Molecular neurobiology, 2019, 10.1007/s12035-018-1240-4

NTPDase2 is necessary for regulation of bile duct epithelial proliferation by portal fibroblasts, Sevigny, J, Kruglov, EA, Jhandier, MN, Dranoff, JA, The FASEB Journal, 2004

Prevention and reversal of thrombotic and inflammatory processes, Leclerc, MC, St George, M, Gendron, FP, Sévigny, J, Beaudoin, AR, Emerging therapeutic targets, 1998, 10.1517/14728222.2.1.61

Synthesis, In-vitro evaluation and molecular docking studies of oxoindolin phenylhydrazine carboxamides as potent and selective inhibitors of ectonucleoside triphosphate diphosphohydrolase (NTPDase), Iqbal, J, Sévigny, J, Pelletier, J, Hameed, A, Al-Rashida, M, Afzal, S, Bioorganic chemistry, 2021, 10.1016/j.bioorg.2021.104957

Distinctive inhibition of alkaline phosphatase isozymes by thiazol-2-ylidene-benzamide derivatives: Functional insights into their anticancer role, Iqbal, J, Sevigny, J, Lecka, J, Hameed, A, Shah, SJA, Saeed, A, Ejaz, SA, Journal of cellular biochemistry, 2018, 10.1002/jcb.26692

Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception, Molliver, DC, Sevigny, J, Lavoie, EG, Vongtau, HO, Neuroscience, 2011, 10.1016/j.neuroscience.2011.07.044

Suppression of ATP diphosphohydrolase/CD39 in human vascular endothelial cells, Robson, SC, Schulte am Esch, J, Csizmadia, E, Guckelberger, O, Goepfert, C, Sévigny, J, Koziak, K, Kaczmarek, E, Imai, M, Biochemistry, 1999, 10.1021/bi990543p

Rat submandibular glands secrete nanovesicles with NTPDase and 5'-nucleotidase activities, van Haaster, MM, Ostuni, MA, Sevigny, J, Pelletier, J, Hattab, C, Egido, P, Balcarcel, NB, Gonzalez, DA, Purinergic signalling, 2015, 10.1007/s11302-014-9437-0

Canalicular ecto-ATPase is a novel member of the GDA 1/CD39 NTPase family, Robson, SC, Smith, NR, Csizmadia, E, Lemmens, R, Sevigny, J, Hepatology, 1999

Purification, characterization, and localization of an ATP diphosphohydrolase in porcine kidney, V, uffel, L, Waelkens, E, Kittel, A, Grondin, G, Beaudoin, AR, Sévigny, J, Kupers, L, Lemmens, R, American journal of physiology Renal physiology, 2000, 10.1152/ajprenal.2000.278.6.F978

The ecto-ATPase NTPDase2 is expressed by astrocytic type-B cells of the adult neurogenic subventricular zone and in germinal zones of the developing rat brain, Zimmermann, H., Hammer, K., Gerstberger, R., Barth, S. W., Robson, S. C., Mishra, S. K., Sevigny, J., Braun, N., 2003

Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors, Paulo Correia-de-Sá, Jean Sévigny, Julie Pelletier, António Oliveira, Adélio Vilaça, Rui Lemos, Rolando Freitas, José Marinhas, Maria Adelina Costa, Fátima Ferreirinha, Maria Teresa Magalhães-Cardoso, Catarina Bessa-Andrês, Rui Pinto-Cardoso, José Bernardo Noronha-Matos, Stem Cell Research & Therapy, 2023, 10.1186/s13287-023-03315-6

Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling, Robson, SC, Sevigny, J, Zimmermann, H, Braun, N, Gill, PS, Shi, H, Tripp, SR, Fausther, M, Isaac, J, Kishore, BK, American journal of physiology Renal physiology, 2005, 10.1152/ajprenal.00108.2004

Ecto-5'-nucleotidase/CD73 contributes to the radiosensitivity of T24 human bladder cancer cell line, Battastini, AMO, Morrone, FB, Sevigny, J, Filho, AB, Roesler, R, de Paula, PB, Tremblay, A, Rockenbach, L, Cappellari, AR, Filippi-Chiela, EC, Figueiro, F, Dietrich, F, Journal of cancer research and clinical oncology, 2018, 10.1007/s00432-017-2567-3

Novel and specific inhibitors of ectonucleotidases, Fischer, Bilha, Sevigny, Jean, Munkonda, Mercedes, Lecka, Joanna, Gillerman, Irina, 2008

Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8, Sévigny, J, es, MJ, Fern, Robson, SC, Lecka, J, Kukulski, F, Lévesque, SA, Bigonnesse, F, Biochemistry, 2004, 10.1021/bi0362222

Nucleoside triphosphate diphosphohydrolases role in the pathophysiology of cognitive impairment induced by seizure in early age, Bonan, CD, Sevigny, J, Souza, DO, Bogo, MR, Casali, E, Bellaver, B, Savio, LE, Vuaden, FC, Cognato, GD, Neuroscience, 2011, 10.1016/j.neuroscience.2011.01.065

Physical exercise prevents memory impairment in an animal model of hypertension through modulation of CD39 and CD73 activities and A2A receptor expression, Schetinger, MRC, Sevigny, J, Morsch, VM, Rubin, MA, Bello-Klein, A, Tremblay, A, Carvalho, F, Gutierres, JM, Bagatini, MD, Zanini, D, Manfredi, LH, Cardoso, AM, Journal of hypertension, 2019, 10.1097/HJH.0000000000001845

Tumor-neutrophil crosstalk promotes in vitro and in vivo glioblastoma progression, Elizandra Braganhol, Nils Ludwig, Niels O. S. Câmara, Jean Sévigny, Anelise B. Araújo, Paulo V. Worm, Marcia R. Wink, Marcelo L. Lamers, Fernanda Visioli, Ana H. Paz, Giselle M. Kroeff, Aline M. de Abreu, Gabriela S. Lenz, Aline S. Rubenich, Nicolly E. Gelsleichter, Leonardo F. Diel, Kerolainy A. Gadelha, Maico T. Cunha, Jordana L. Domagalski, Gabriela F.S. Gentil, Fernanda C. Teixeira, Eloisa M. da Silva, Luisa M. Silva, Paulo J. Basso, Mariana R. Aubin, Natalia Omizzollo, Priscila O. de Souza, Dominique S. Rubenich, Frontiers in Immunology, 2023, 10.3389/fimmu.2023.1183465

Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis, Laketa, D, Nedeljkovic, N, Sevigny, J, Pekovic, S, Bjelobaba, I, Savic, D, Bozic, I, Lavrnja, I, Jakovljevic, M, Frontiers in cellular neuroscience, 2017, 10.3389/fncel.2017.00333

Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases, Iqbal, Jamshed, Papatriantafyllopoulou, Constantina, Muddassar, Muhammad, Sevigny, Jean, Lecka, Joanna, Kostakis, George E., Shah, Muhammad Shakil, Abbas, Ghulam, Raza, Rabia, al-Rashida, Mariya, European Journal of Medicinal Chemistry, 2013, 10.1016/J.EJMECH.2013.06.015

Hydrolysis of P2-purinoceptor agonists by a purified ectonucleotidase from the bovine aorta, the ATP-diphosphohydrolase, Beaudoin, AR, D'Orléans-Juste, P, Sévigny, J, Picher, M, Biochemical pharmacology, 1996, 10.1016/0006-2952(96)00086-x

Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis, Sévigny, J, Knowles, AF, Jain, D, Zimmermann, H, Braun, N, Toure, J, Kruglov, EA, Dranoff, JA, Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2004, 10.1136/jim-52-07-42

Feed-forward inhibition of CD73 and upregulation of adenosine deaminase contribute to the loss of adenosine neuromodulation in postinflammatory ileitis, Correia-de-Sa, P, Sevigny, J, Pelletier, J, Dias, AS, Silva, I, Ferreirinha, F, Magalhaes-Cardoso, MT, Vieira, C, Mediators of inflammation, 2014, 10.1155/2014/254640

CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness, Takashima, A, Enjyoji, K, Matsue, H, Sévigny, J, Robson, SC, Kumamoto, T, Mizumoto, N, Nature medicine, 2002, 10.1038/nm0402-358

Synthesis, biological evaluation, and docking studies of new pyrazole-based thiourea and sulfonamide derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase, Iqbal, J, Oh, CH, Sevigny, J, Pelletier, J, Sbenati, RM, Zaraei, SO, Anbar, HS, Zaib, S, El-Gamal, MI, Ullah, S, Bioorganic chemistry, 2020, 10.1016/j.bioorg.2020.103783

Regulation of liver fibrosis by P2Y nucleotide receptors, Wells, R. G., Gaca, M., Robson, S. C., Sevigny, J., Kruglov, E. A., Dranoff, J. A., 2004

The expression of NTPDase1 and -2 of Leishmania infantum chagasi in bacterial and mammalian cells: Comparative expression, refolding and nucleotidase characterization, Fietto, JLR, Sevigny, J, Almeida, MR, Bressan, GC, Silva-Junior, A, Lecka, J, Pelletier, J, Barreto, LP, Rabelo, ILA, Agripino, JM, Tremblay, A, Bastos, MS, Protein expression and purification, 2017, 10.1016/j.pep.2016.11.004

Thromboregulatory potential of endothelial CD39/nucleoside triphosphate diphosphohydrolase: modulation of purinergic signalling in platelets, Enjyoji, K, Guckelberger, O, Imai, M, Sévigny, J, Robson, SC, Emerging therapeutic targets, 2000, 10.1517/14728222.4.2.155

Localization of the ecto-NTPDases in the murine reproductive tract, Sevigny, Jean, Robson, Simon C., Guckelberger, Olaf, Czismadia, Eva, Fausther, Michel, Pelletier, Julie, Lavoie, Elise G., Martin-Satue, Mireia, 2008

Dual role of P2Y6 receptors in the human urinary bladder: On the role of ATP released from the urothelium, Correia-de-S, Paulo, Sévigny, Jean, Silva-Ramos, Miguel, Ferreirinha, Ftima, Correia, Joana, rina, Timteo, M. Alex, Silva, Isabel, 2013, 10.1016/j.autneu.2013.08.021

Disordered hemostasis and thromboregulation in cd39-deficient mice, Sévigny, Jean, 1999

Domino reactions of chromone-3-carboxylic acids with aminoheterocycles: synthesis of heteroannulated pyrido[2,3-c]coumarins and their optical and biological activity, Langer, P, Lecka, J, Sévigny, J, Villinger, A, Ivanov, A, Lochbrunner, S, Friedrich, A, Iqbal, J, Khan, SU, Ejaz, SA, Hassan, S, Chirkina, E, Janke, J, Miliutina, M, European journal of organic chemistry, 2017, 10.1002/ejoc.201701276

ATP-diphosphohydrolases, Beaudoin Adrien, R., Jean Sévigny, 1998

Blue blocker glasses impede the capacity of bright light to suppress melatonin production, Hébert, M, Sévigny, J, Paquet, N, Sasseville, A, Journal of pineal research, 2006, 10.1111/j.1600-079X.2006.00332.x

Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors, Fischer, B, Sevigny, J, Pelletier, J, Levesque, SA, Bigonnesse, F, Haas, M, Reiser, G, Lecka, J, Eliahu, S, Journal of medicinal chemistry, 2010, 10.1021/jm100597c

Is Failure to Regulate Neutrophil Recruitment in Cystic Fibrosis Caused by the Loss of Airway Ntpdasei?, Sevigny, J., Boucher, R. C., Ribeiro, C. M., Pelletier, J., Fausther, M., Picher, M., 2009

Ecto-nucleotidases: Multiplicity and role in the nervous system, Robson, S. C., Sevigny, J., Failer, B. U., Vollmayer, P., Braun, N., Zimmermann, H. I., 2002

The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver, Sévigny, J, Zimmermann, H, Braun, N, Robson, SC, Kruglov, EA, Dranoff, JA, Hepatology (Baltimore, Md ), 2002, 10.1053/jhep.2002.36823

Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 - a promising target for cancer immunotherapy, Müller, CE, Tolosa, E, Sévigny, J, Pelletier, J, Al-Hroub, H, Idris, R, Lopez, V, Winzer, R, Mirza, S, Schäkel, L, Journal for immunotherapy of cancer, 2022, 10.1136/jitc-2022-004660

Le monde des nucléotides extracellulaires, Beaudoin, AR, Sévigny, J, Medecine sciences : M/S, 1994

High expression and activity of ecto-5'-nucleotidase/CD73 in the male murine reproductive tract, Sevigny, J, Kukulski, F, Aliagas, E, Lecka, J, Fausther, M, Lavoie, EG, Martin-Satue, M, Histochemistry and cell biology, 2010, 10.1007/s00418-010-0704-z

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis, Powers, AC, Sevigny, J, Dai, C, Carnahan, RH, Levy, SE, Prasad, N, Shultz, LD, Greiner, DL, Dean, ED, Shostak, A, Virostko, J, Goff, MT, Cooper, T, Pelletier, J, Weller, KP, Flaherty, DK, Poffenberger, G, la, R, Aram, Walker, JT, Shrestha, S, Phillips, N, Brissova, M, Saunders, DC, Cell metabolism, 2019, 10.1016/j.cmet.2018.10.007

NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD, Jobin, C, Sévigny, J, Robaye, B, Brochu, G, Vallières, L, Dumas, A, Gomes Marconato, D, Pelletier, J, Lecka, J, Salem, M, Gut, 2022, 10.1136/gutjnl-2020-320937

Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies, Iqbal, J, Sevigny, J, Pelletier, J, Saeed, A, Zaib, S, Mahmood, A, Saeed, K, Mumtaz, A, Bioorganic chemistry, 2020, 10.1016/j.bioorg.2020.103996

Changes in ecto-nucleotidases in murine and human endometria along the female cycle, Martin Satue, Mireia, Sevigny, J., Torrejon-Escribano, B., Lavoie, E. G., Ponce, J., Vidal, A., Taco-Sanchez, M. R., Aliagas Marin, Elisabet, Purinergic Signalling, 2010

Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers, Correia-de-Sa, P, Sevigny, J, Pelletier, J, Ribeiro, S, Magalhaes-Cardoso, T, Ferreirinha, F, Costa, MA, Paramos-de-Carvalho, D, Pinheiro, AR, Herman-de-Sousa, C, Cells, 2020, 10.3390/cells9030651

Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2, Dranoff, JA, Sevigny, J, Lavoie, EG, Kruglov, EA, Jh, ier, MN, The Journal of biological chemistry, 2005, 10.1074/jbc.M412371200

Perturbations in hemostasis and thrombosis in cd39-mutant mice: implications for experimental therapeutics of CD39/NTPDase-1, Enjyoji, K., Lambert, R. D., Kaczmarek, E., Gaciong, Z., Schulte am Esch, J., 2nd, Guckelberger, O., Sévigny, J., Imai, M., Robson, S. C., Ecto-ATPases and related ectonucleotidases : proceedings of the Second International Workshop on Ecto-ATPases and Related Ecotonucleotidases, held in Diepenbeek, Belgium, June 14-18, 1999, 1999

From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease, Robson, SC, Friess, H, Csizmadia, E, Enjyoji, K, Berberat, PO, Sevigny, J, A-Rahim, YI, Kunzli, BM, Friedman, DJ, Proceedings of the National Academy of Sciences of the United States of America, 2009, 10.1073/pnas.0902869106

Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8, Sevigny, J, Dranoff, JA, Zimmermann, H, Pelletier, J, Levesque, SA, Kukulski, F, Lecka, J, Fausther, M, American journal of physiology Gastrointestinal and liver physiology, 2007, 10.1152/ajpgi.00293.2006

17β-Estradiol-Induced Synaptic Rearrangements Are Accompanied by Altered Ectonucleotidase Activities in Male Rat Hippocampal Synaptosomes, Grkovic, I, Nedeljkovic, N, Stanojlovic, M, Sevigny, J, Martinovic, J, Drakulic, D, Zaric, M, Mitrovic, N, Journal of molecular neuroscience : MN, 2017, 10.1007/s12031-016-0877-6

Polyoxometalates--potent and selective ecto-nucleotidase inhibitors, Muller, CE, Stephan, H, Kortz, U, Sevigny, J, Zimmermann, H, Pietzsch, HJ, Haider, A, Lecka, J, Fedorov, VE, Brylev, KA, Hanck, T, Li, W, Fiene, A, Lee, SY, Biochemical pharmacology, 2015, 10.1016/j.bcp.2014.11.002

Demonstration and immunolocalization of ATP diphosphohydrolase in the pig digestive system, Beaudoin, AR, Roy, J, Gendron, FP, Grondin, G, Sévigny, J, The American journal of physiology, 1998, 10.1152/ajpgi.1998.275.3.G473

ATP-DIPHOSPHOHYDROLASES, PROCESS OF PURIFICATION THEREOF AND PROCESS OF PRODUCING THEREOF BY RECOMBINANT TECHNOLOGY, Beaudoin Adrien, R., Jean Sévigny, 1996

NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression, Battastini, AM, Sevigny, J, Morrone, FB, Edelweiss, MI, Pugliese, M, Figueiro, F, Dietrich, F, Braganhol, E, Rockenbach, L, Purinergic signalling, 2014, 10.1007/s11302-014-9405-8

Blockade of P2Y receptors prevents cirrhosis due to carbon tetrachloride but not extrahepatic bile duct ligation, Sevigny, Jean, Robson, Simon, Kruglov, Emma A., Dranoff, Jonathan A., 2004

Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae, Robson, SC, Qawi, I, Goepfert, C, Guckelberger, O, Imai, M, Schulte am Esch, J, Blusztajn, JK, Sévigny, J, Kittel, A, Kaczmarek, E, Koziak, K, The Journal of biological chemistry, 2000, 10.1074/jbc.275.3.2057

Transient changes in the localization and activity of ecto-nucleotidases in rat hippocampus following lipopolysaccharide treatment, Kirley, Terence L., Sevigny, Jean, Pelletier, Julie, Sperlagh, Beata, Kittel, Agnes, International Journal of Developmental Neuroscience, 2007, 10.1016/J.IJDEVNEU.2007.05.007

Expanding the Alkaline Phosphatase Inhibition, Cytotoxic and Proapoptotic Profile of Biscoumarin‐Iminothiazole and Coumarin‐Triazolothiadiazine Conjugates, Saeed, A, Sévigny, J, Lecka, J, Umar, MI, Ibrar, A, Ejaz, SA, Iqbal, J, ChemistrySelect, 2018, 10.1002/slct.201801863

Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium, a, IG, de Ar, Martin-Satue, M, Condom, E, Sevigny, J, Ponce, J, Taco, MD, Torrejon-Escribano, B, Vidal, A, Aliagas, E, Purinergic signalling, 2013, 10.1007/s11302-012-9345-0

Impact of Ectoenzymes on P2 and P1 Receptor Signaling, Sevigny, Jean, Levesque, Sebastien A., Kukulski, Filip, Advances in Pharmacology, 2011, 10.1016/B978-0-12-385526-8.00009-6

Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors, Jamshed Iqbal, Jean Sévigny, Julie Pelletier, Muhammad Siraj Khan Jadoon, RSC Advances, 2023, 10.1039/D3RA04266A

2-MeS-beta,gamma-CCl2-ATP is a potent agent for reducing intraocular pressure, Fischer, B, Sevigny, J, Lecka, J, Weisman, GA, Camden, J, Pintor, J, Perez de Lara, MJ, Martin-Gil, A, Eliahu, S, Journal of medicinal chemistry, 2010, 10.1021/jm100030u

Schiff bases of tryptamine as potent inhibitors of nucleoside triphosphate diphosphohydrolases (NTPDases): Structure-activity relationship, Iqbal, J, Sevigny, J, Lecka, J, Khan, H, Perveen, S, Taha, M, Wadood, A, Afzal, S, Salar, U, Mohammed Khan, K, Kanwal, Kanwal, Bioorganic chemistry, 2019, 10.1016/j.bioorg.2018.10.046

NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS colitis, Gulbransen, BD, Galligan, JJ, Robson, SC, Sevigny, J, Fried, DE, Perez-Medina, AL, Grubisic, V, American journal of physiology Gastrointestinal and liver physiology, 2019, 10.1152/ajpgi.00104.2019

Targeting platelet aggregation: CD39 gene transfer augments nucleoside triphosphate diphosphohydrolase activity in injured rabbit arteries, Conte, MS, Robson, SC, Sévigny, J, Rhynhart, KK, Imai, M, Gangadharan, SP, Surgery, 2001, 10.1067/msy.2001.116032

Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation, Rosenberg, RD, Robson, SC, Wagner, DD, Csizmadia, E, Beeler, DL, Lech, M, Rayburn, H, Edelberg, JM, Imai, M, Esch, JS, Christie, PD, Frenette, PS, Lin, Y, Sévigny, J, Enjyoji, K, Nature medicine, 1999, 10.1038/12447

Comparative hydrolysis of extracellular adenine nucleotides and adenosine in synaptic membranes from porcine brain cortex, hippocampus, cerebellum and medulla oblongata, Komoszynski, M, Sévigny, J, Kukulski, F, Brain research, 2004, 10.1016/j.brainres.2004.09.044

Trafficking and intracellular ATPase activity of human ecto-nucleotidase NTPDase3 and the effect of ER-targeted NTPDase3 on protein folding, Kirley, TL, Sevigny, J, Ivanenkov, VV, Biochemistry, 2008, 10.1021/bi800402q

Erratum: Changes in expression and activity levels of ecto-5'-nucleotidase/ CD73 along the mouse female estrous cycle, Martín-Satué, M., Solsona, C., Sévigny, J., a, I., Gómez De Ar, Lavoie, E. G., Torrejón-Escribano, B., Aliagas, E., Acta Physiologica, 2010

Characterization and antiproliferative activity of glioma-derived extracellular vesicles, Battastini, AMO, Figueiro, F, Guterres, SS, Pohlmann, AR, Sevigny, J, Rohden, F, Colombo, M, Souto, GD, J, rey, EHF, Moritz, CEJ, Pizzato, PR, Lopes, DV, de Fraga Dias, A, Scholl, JN, Nanomedicine (London, England), 2020, 10.2217/nnm-2019-0431

Generation and characterization of a monoclonal antibody as the first specific inhibitor of human NTPDase3, Sevigny, Jean, Kirley, Terence, Kuenzli, Beat, Tremblay, Alain, Pelletier, Julie, Ivanenkov, Vasily, Fausther, Michel, Munkonda, Mercedes, 2008

Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis", Barrachina, M, Martin-Satue, M, Ferrer, I, Romeu, M, Roca, M, Sevigny, J, Villar-Menendez, I, Aliagas, E, Purinergic signalling, 2013, 10.1007/s11302-013-9370-7

Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3, Sévigny, J, Lecka, J, Lévesque, SA, Kukulski, F, Lavoie, EG, Biochemical pharmacology, 2004, 10.1016/j.bcp.2004.02.012

NUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE (NTPDASE 8) AND USES THEREOF, Jean Sévigny, 2004

IDENTIFICATION OF THE CATALYTIC SUBUNIT OF THE BOVINE LUNG ATP-DIPHOSPHOHYDROLASE, BEAUDOIN, AR, PICHER, M, SEVIGNY, J, Molecular Biology of the Cell, 1995

Light, Adenosine Transporters, And Ecto-nucleotidases Contribute To Adenosine Levels In The Outer Retina, Sevigny, Jean, Dale, Nicholas, Stella, Salvatore L., Jr., 2011

Synthesis and Nucleotide Pyrophosphatase/Phosphodiesterase Inhibition Studies of Carbohydrazides Based on Benzimidazole-Benzothiazine Skeleton, Iqbal, J, Iqbal, M, Sevigny, J, Sultan, S, Aslam, S, Pelletier, J, Ahmad, M, Ullah, S, Kanwal, A, ChemistrySelect, 2020, 10.1002/slct.202003479

Identification of Small Molecule Sulfonic Acids as Ecto-5 '-Nucleotidase Inhibitors, Iqbal, Jamshed, Sevigny, Jean, Lecka, Joanna, Saeed, Aamer, Raza, Rabia, Medicinal Chemistry, 2012

Carbon monoxide can fully substitute heme oxygenase-1 in suppressing the rejection of mouse to rat cardiac transplants, Soares, Miguel P., Bach, Fritz H., Choi, Augustine M., Vercellotti, Gregory, Robson, Simon C., Sevigny, Jean, Anrather, Josef, Csizmadia, Eva, Lin, Yuan, Brouard, Sophie, Smith, Neal, Otterbein, Leo, Balla, Jozsef, Sato, Koichiro, 2000

Quinazoline-4-piperidine sulfamides are specific inhibitors of human NPP1 and prevent pathological mineralization of valve interstitial cells, Mathieu, P, Paquin, JF, Sevigny, J, Lague, P, Barbeau, X, Dautrey, S, Mahmut, A, Boulanger, MC, Forcellini, E, Shayhidin, EE, British journal of pharmacology, 2015, 10.1111/bph.13204

Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells, Wells, RG, Robson, SC, Sevigny, J, Gaca, MD, Kruglov, EA, Ogawa, M, Dranoff, JA, American journal of physiology Gastrointestinal and liver physiology, 2004, 10.1152/ajpgi.00294.2003

CD39 is a caveolar-associated ectonucleotidase, Sévigny, Jean, 1999

Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture, Wells, Rebecca G., Sevigny, Jean, Uemura, Masayuki, Chan, Erick P., Dranoff, Jonathan A., Li, Zhaodong, Hepatology, 2007, 10.1002/HEP.21792

Characterization of CD39/vascular ATP diphosphohydrolase (ATPDase), Bach, F. H., Beaudoin, A. R., Sevigny, J., Siegel, J., Koziak, K., Kaczmarek, E., Robson, S. C., 1997

Distribution, cloning, and characterization of porcine nucleoside triphosphate diphosphohydrolase-1, Sévigny, J, Benrezzak, O, Beaudoin, AR, Kittel, A, uffel, L, V, Lemmens, R, European journal of biochemistry, 2000, 10.1046/j.1432-1327.2000.01462.x

Blockade of CD73 delays glioblastoma growth by modulating the immune environment, Braganhol, E, Teixeira, HF, Figueiro, F, Battastini, AMO, Stefani, MA, Wink, MR, Sevigny, J, Scholl, JN, Lenz, GS, Roliano, GG, Beckenkamp, LR, Iser, IC, Michels, LR, Schuh, RS, Azambuja, JH, Cancer immunology, immunotherapy : CII, 2020, 10.1007/s00262-020-02569-w

Purinergic Signalling in Immune System Regulation in Health and Disease, Pintor, J, Martin-Satue, M, Sevigny, J, Mediators of inflammation, 2015, 10.1155/2015/106863

Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes, Martin-Satue, M, Ponce, J, Matias-Guiu, X, ez-Montoli, ME, Fern, a, I, Sevigny, J, Gomez de Ar, Piulats, JM, Vidal, A, Trapero, C, Rodriguez-Martinez, A, Journal of personalized medicine, 2021, 10.3390/jpm11050331

ATP-diphosphohydrolases, apyrases, and nucleotide phosphohydrolases: Biochemical properties and functions, Picher, M., Sévigny, J., Beaudoin, A. R., Biomembranes: A Multi-Volume Treatise, volume 5 : ATPases, 1996, 10.1016/S1874-5342(06)80015-2

Nucleotide signaling in adult neurogenesis, Robson, S. C., Sevigny, J., Kettenmann, H., Korf, H. W., Schomerus, C., Delic, J., Grimm, Y., Gampe, K., Braun, N., Shukla, V., Mishra, S. K., Langer, D., Zimmermann, H., 2007

Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-β-phosphate scaffold, Fischer, B, Senderowitz, H, Sevigny, J, Gendron, FP, Khazanov, N, Arguin, G, Arad, U, Pelletier, J, Nassir, M, European journal of medicinal chemistry, 2019, 10.1016/j.ejmech.2019.111754

Distribution of ectonucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea, Housley, GD, Robson, SC, Sevigny, J, Thorne, PR, Vlajkovic, SM, Hearing Research, 2002, 10.1016/S0378-5955(02)00460-4

Generation and characterization of a monoclonal antibody as the first specific inhibitor of human NTPDase3, Sevigny, J., Kirley, T. L., Kuenzli, B., Tremblay, A., Pelletier, J., Ivanenkov, V. V., Fausther, M., Munkonda, M. N., The FEBS Journal, 2010

NUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE (NTPDASE 8) AND USES THEREOF, Jean Sévigny, 2004

Ecto-5'-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model, Ulrich, H, Battastini, AM, Sevigny, J, Lecka, J, Roesler, R, Abujamra, AL, Figueiro, F, Oliveira, FH, Dietrich, F, Souza, HD, Pillat, MM, Cappellari, AR, PloS one, 2015, 10.1371/journal.pone.0140996

Immunocytochemical localization of NTPDases1 and 2 in the neural retina of mouse and zebrafish, Faillace, MP, Schwarzbaum, PJ, Sevigny, J, Lavoie, EG, Alfie, LD, Ricatti, MJ, Synapse (New York, N Y ), 2009, 10.1002/syn.20605

Diacylhydrazine Derivatives of 2-(5-(Pyridin-3-yl)-2H-Tetrazol-2-yl)Acetohydrazide and 2-(5-(Pyridin-4-yl)-2H-Tetrazol-2-yl)Acetohydrazide as Potential Inhibitors of Nucleotide Pyrophosphatase, J. Iqbal, J. Sévigny, J. Lecka, S. U. Khan, A. Saeed, S. A. Ejaz, G. Shabir, M. Arif, Russian Journal of Bioorganic Chemistry, 2022, 10.1134/s1068162022050053

Antenatal Dexamethasone Treatment Induces Sex-dependent Upregulation of NTPDase1/CD39 and Ecto-5'-nucleotidase/CD73 in the Rat Fetal Brain, Laketa, D, Nedeljkovic, N, Sevigny, J, Nestorovic, N, Ristic, N, Trifunovic, S, Stevanovic, I, Lavrnja, I, Manojlovic-Stojanoski, M, Cellular and molecular neurobiology, 2021, 10.1007/s10571-021-01081-8

E-NTPDase family, Sévigny, J, Book E-NTPDase family, 2013, 10.1007/978-1-4419-0461-4_197

Localization of CD39L1/vascular NTP diphosphohydrolase (NTPDase2) in murine kidney, Robson, S. C., Sevigny, J., Isaac, J., Kishore, B. K., 2002

Changes in expression and activity levels of ecto-5'-nucleotidase/CD73 along the mouse female estrous cycle, Martin-Satue, M., Solsona, C., Sevigny, J., Gomez de Aranda, I., Lavoie, E. G., Torrejon-Escribano, B., Aliagas, E., Acta Physiologica, 2010, 10.1111/J.1748-1716.2010.02095.X

Development and characterization of CD73-siRNA-loaded nanoemulsion: effect on C6 glioma cells and primary astrocytes, Braganhol, E, Teixeira, HF, Battastini, AMO, Spanevello, RM, Sevigny, J, Stefani, MA, Berenguer, AM, Azambuja, JH, Bruxel, F, Teixeira, FC, Pharmaceutical development and technology, 2020, 10.1080/10837450.2019.1705485

Thienopyridines as specific inhibitors of NTPDase1, Sevigny, Jean, Fausther, Michel, Lecka, Joanna, 2008

Synthesis of biphenyl oxazole derivatives via Suzuki coupling and biological evaluations as nucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors, Iqbal, J, Hassan, A, Sevigny, J, Pelletier, J, Saeed, A, Rahman, F, Ullah, S, Ahmad, H, European journal of medicinal chemistry, 2020, 10.1016/j.ejmech.2020.112759

Generation and Characterization of Specific Antibodies to the Murine and Human Ectonucleotidase NTPDase8, Sevigny, J, Bigonnesse, F, Fausther, M, Lecka, J, Salem, M, Pelletier, J, Frontiers in pharmacology, 2017, 10.3389/fphar.2017.00115

P2Y Receptors Regulate CXCL10 Expression and Secretion in Mouse Intestinal Epithelial Cells, Sevigny, J, Robaye, B, Pelletier, J, Tremblay, A, Salem, M, Frontiers in pharmacology, 2018, 10.3389/fphar.2018.00149

Identification, characterization, and immunolocalization of a nucleoside triphosphate diphosphohydrolase in pig liver, Beaudoin, AR, Sévigny, J, Gendron, FP, Grondin, G, Leclerc, MC, Archives of biochemistry and biophysics, 2000, 10.1006/abbi.2000.1800

NTPDase1 (CD39) controls nucleotide dependent vasomotion in mouse, Thorin, Eric, Marceau, Francois, D'Orleans-Juste, Pedro, Robaye, Bernard, Thorin-Trescases, Nathalie, Drouin, Annick, Fuerstenau, Cristina Ribas, Kauffenstein, Gilles, Sevigny, Jean, 2010

NTPDase1 (cd39) regulates extracellular nucleotides-induced vasomotion, Sevigny, J., Kauffenstein, G., 2008

Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds, Finger, Thomas E., Sevigny, Jean, Lavoie, Elise G., Sullivan, Susan L., Bartel, Dianna L., Journal of Comparative Neurology, 2006, 10.1002/CNE.20954

NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse, Sevigny, J, Thorin, E, Marceau, F, D'Orleans-Juste, P, Robaye, B, Bachelard, H, Thorin-Trescases, N, Drouin, A, Kauffenstein, G, Cardiovascular research, 2010, 10.1093/cvr/cvp265

E-NTPDase family, Sévigny, J, Book E-NTPDase family, 2018, 10.1007/978-1-4614-6438-9_197-1

Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions, Chen, JF, Cunha, RA, Muller, CE, Bynoe, MS, El-Tayeb, A, Sevigny, J, Matos, M, Augusto, E, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.5817-12.2013

Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitor, Hassan, A, Iqbal, J, Sévigny, J, Pelletier, J, Saeed, A, Zaman, G, Afzal, S, Murtaza, A, Bioorganic chemistry, 2021, 10.1016/j.bioorg.2021.105240

Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors, Iqbal, J, Sévigny, J, Pelletier, J, Ullah, S, ACS omega, 2022, 10.1021/acsomega.2c03473

Functionalized Oxoindolin Hydrazine Carbothioamide Derivatives as Highly Potent Inhibitors of Nucleoside Triphosphate Diphosphohydrolases, Iqbal, J, Sevigny, J, Pelletier, J, Hameed, A, Al-Rashida, M, Afzal, S, Frontiers in pharmacology, 2020, 10.3389/fphar.2020.585876

Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth, Figueiró, F, Battastini, AMO, Sévigny, J, Scholl, JN, Silva, LFL, de Fraga Dias, A, Lopes, DV, Purinergic signalling, 2021, 10.1007/s11302-021-09775-w

NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female, Sevigny, J, Robaye, B, Pelletier, J, Kauffenstein, G, Babou Kammoe, RB, Biomolecules, 2021, 10.3390/biom11020147

Localization of CD39/vascular NTP diphosphohydrolase (NTPDase) in rat kidney., Robson, S. C., Sevigny, J., Tripp, S. R., Isaac, J., Kishore, B. K., 2002

Ecto-nucleotidases: Multiplicity and role in the nervous system, Robson, S. C., Sevigny, J., Failer, B. U., Vollmayer, P., Braun, N., Zimmermann, H. I., 2002

2‐Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors, Christa E. Müller, Michael Gütschow, Vigneshwaran Namasivayam, Thanigaimalai Pillaiyar, Jean Sévigny, Julie Pelletier, Katharina Sylvester, Tim Keuler, Sang‐Yong Lee, Markus Pietsch, Salahuddin Mirza, Laura Schäkel, Archiv der Pharmazie, 2021, 10.1002/ardp.202100300

Identification and characterization of membrane-associated hepatic NTP diphosphohydrolases., Robson, S. C., Kirley, T., Zimmermann, H., Smith, R. N., Csizmadia, E., Kruglov, E., Lemmens, R., Braun, N., Dranoff, J. A., Sevigny, J., 2001

Nonhydrolyzable ATP analogues as selective inhibitors of human NPP1: a combined computational/experimental study, Sevigny, J, Senderowitz, H, Fischer, B, Pelletier, J, Luyindula, P, Oscar, Jr, Eliahu, S, Simhaev, L, Ben-David, G, Lecka, J, Journal of medicinal chemistry, 2013, 10.1021/jm400918s

Structural and post-translational modifications of ATP diphosphohydrolase/CD39, Robson, S. C., Kaczmarek, E., Esch, J. S. A., Sevigny, J., 1998

2-Substituted 7-trifluoromethyl-thiadiazolopyrimidones as alkaline phosphatase inhibitors. Synthesis, structure activity relationship and molecular docking study, Langer, P, Iqbal, J, Sevigny, J, Lecka, J, Ehlers, P, Kalugin, SN, Turmukhanova, MZ, Abilov, ZA, Safarov, S, Amjad, ST, Khan, SU, Yelibayeva, N, Ejaz, SA, Ospanov, M, Jafari, B, European journal of medicinal chemistry, 2018, 10.1016/j.ejmech.2017.11.068

Deazapurine Analogues Bearing a 1H-Pyrazolo[3,4-b]pyridin- 3(2H)-one Core: Synthesis and Biological Activity, Langer, P, Iqbal, J, Sévigny, J, Lecka, J, Iaroshenko, VO, Hein, M, Ejaz, SA, Mahmood, A, Afzal, S, European journal of organic chemistry, 2018, 10.1002/ejoc.201800163

Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors, Muller, CE, Namasivayam, V, Sevigny, J, Pelletier, J, Vu, TH, Mirza, S, Lopez, V, Lee, SY, Luo, X, Idris, RM, Schmies, CC, Schakel, L, Frontiers in pharmacology, 2020, 10.3389/fphar.2020.01294

Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration, Sevigny, J, Martin-Satue, M, Levesque, SA, Kauffenstein, G, Lecka, J, Ben Yebdri, F, Kukulski, F, Cytokine, 2009, 10.1016/j.cyto.2009.02.011

The molecular and functional properties of E-NTPDasex/1, E-NTPDase2 and ecto-5’-nucleotidase in nervous tissue, Robson, S. C., Sévigny, J., Marxen, M., Kohring, K., Heine, P., Braun, N., Zimmermann, H., Ecto-ATPases and related ectonucleotidases : proceedings of the Second International Workshop on Ecto-ATPases and Related Ecotonucleotidases, held in Diepenbeek, Belgium, June 14-18, 1999, 1999

Influence of the diversified structural variations at the imine functionality of 4-bromophenylacetic acid derived hydrazones on alkaline phosphatase inhibition: synthesis and molecular modelling studies, Iqbal, J, Sévigny, J, Lecka, J, Simpson, J, Hameed, S, Ali Shah, SJ, Khan, SU, Ejaz, SA, Ibrar, A, Khan, I, RSC advances, 2015, 10.1039/c5ra14836g

Erratum to: 17β-Estradiol-Induced Synaptic Rearrangements Are Accompanied by Altered Ectonucleotidase Activities in Male Rat Hippocampal Synaptosomes, Grkovic, I, Nedeljkovic, N, Stanojlovic, M, Sevigny, J, Martinovic, J, Drakulic, D, Zaric, M, Mitrovic, N, Journal of molecular neuroscience : MN, 2017, 10.1007/s12031-016-0879-4

Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: potential role of NTPDase3 in insulin secretion, Sevigny, J, Friess, H, Kunzli, BM, Kukulski, F, Kauffenstein, G, Fausther, M, Lavoie, EG, American journal of physiology Endocrinology and metabolism, 2010, 10.1152/ajpendo.00126.2010

Regulatory T Cells Negatively Affect IL-2 Production of Effector T Cells through CD39/Adenosine Pathway in HIV Infection, Levy, Yves, Lelievre, Jean-Daniel, Sevigny, Jean, Tremblay, Alain, Routy, Jean-Pierre, Koek, Ayrin, Ghadimi, Elnaz, Younas, Mehwish, Hulin, Anne, Carriere, Matthieu, Yatim, Ahmad, Seddiki, Nabila, Jenabian, Mohammad-Ali, PLOS Pathogens, 2013, 10.1371/JOURNAL.PPAT.1003319

Probing the high potency of pyrazolyl pyrimidinetriones and thioxopyrimidinediones as selective and efficient non-nucleotide inhibitors of recombinant human ectonucleotidases, Iqbal, J, Sevigny, J, Lecka, J, Zaib, S, Khan, I, Ejaz, SA, Hameed, S, Andleeb, H, Bioorganic chemistry, 2019, 10.1016/j.bioorg.2019.03.067

Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase, Iqbal, J, Saeed, A, Bajorath, J, Sevigny, J, Lecka, J, Nisa, ZU, Hassan, S, Shah, SJ, Channar, PA, Chemical biology & drug design, 2017, 10.1111/cbdd.12861

ATP-DIPHOSPHOHYDROLASES AND PROCESS OF PURIFICATION THEREOF, Beaudoin Adrien, R., Jean Sévigny, 1996

4-Aminopyridine based amide derivatives as dual inhibitors of tissue non-specific alkaline phosphatase and ecto-5'-nucleotidase with potential anticancer activity, Iqbal, J, Shabir, G, Sevigny, J, Lecka, J, Ullah Khan, S, Shehzad, M, Saeed, A, Ejaz, SA, Hassan, S, Bioorganic chemistry, 2018, 10.1016/j.bioorg.2017.11.013

Impact of ectonucleotidases in autonomic nervous functions, Sevigny, J, Correia-de-Sa, P, Schetinger, MR, Cardoso, AM, Autonomic neuroscience : basic & clinical, 2015, 10.1016/j.autneu.2015.04.014

The C-terminal cysteine-rich region dictates specific catalytic properties in chimeras of the ectonucleotidases NTPDase1 and NTPDase2, Zimmermann, H, Servos, J, Robson, SC, Sévigny, J, Braun, N, Heine, P, European journal of biochemistry, 2001, 10.1046/j.1432-1033.2001.01896.x

Design and synthesis of new adamantyl derivatives as promising antiproliferative agents., El-Gamal MI, Al-Tel TH, Iqbal J, Sévigny J, Pelletier J, Gelsleichter NE, El-Awady R, Oh CH, Abdel-Maksoud MS, Menon V, Hanan S. Anbar, El-Gamal R, Ullah S, AlKubaisi BO, Zaraei SO, Shahin AI, European journal of medicinal chemistry, 2022, 10.1016/j.ejmech.2022.114958

Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation, Zimmermann, H, Robson, SC, Sévigny, J, Ikehara, Y, Gachet, C, Korf, HW, Schomerus, C, Füllgrabe, M, Shukla, V, Braun, N, Mishra, SK, Development (Cambridge, England), 2006, 10.1242/dev.02233

Sequencing, cloning and expression of porcine cd39, uffel, L., V, Sévigny, J., Kittel, A., Lemmens, R. A., Ecto-ATPases and related ectonucleotidases : proceedings of the Second International Workshop on Ecto-ATPases and Related Ecotonucleotidases, held in Diepenbeek, Belgium, June 14-18, 1999, 1999

Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase, Lemmens, R, Smith, RN, Csizmadia, E, Waelkens, E, Robson, SC, Sévigny, J, The Journal of biological chemistry, 2000, 10.1074/jbc.275.8.5640

The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance, Zimmermann, H, Sevigny, J, Robson, SC, Purinergic signalling, 2006, 10.1007/s11302-006-9003-5

Adenosine A receptor and ecto-5'-nucleotidase/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE), Correia-de-Sa, P, Cordeiro, JM, Sevigny, J, Pelletier, J, Rangel, R, Santos, A, Lobo, MG, Mendes, M, Oliveira, A, Ferreirinha, F, Barros-Barbosa, AR, Purinergic signalling, 2016, 10.1007/s11302-016-9535-2

Exploring chromone sulfonamides and sulfonylhydrazones as highly selective ectonucleotidase inhibitors: Synthesis, biological evaluation and in silico study, Mariya al-Rashida, Jamshed Iqbal, Jean Sévigny, Julie Pelletier, Habsah Mohamad, Asnuzilawati Asari, Abdul Hameed, Muhammad Siraj Khan Jadoon, Abid Mahmood, Muhammad Saeed, Hafiza Amna Younus, Bioorganic Chemistry, 2023, 10.1016/j.bioorg.2023.106450

Bioscaffold developed with decellularized human amniotic membrane seeded with mesenchymal stromal cells: assessment of efficacy and safety profiles in a second-degree burn preclinical model, Marcia Wink, Jean Sévigny, Marilda Da Cruz Fernandes, Pablo Fagundes Pase, Aline Francielle Damo Souza, Thaís Casagrande Paim, Carla Zanatelli, Luiza Pretto, Liliana Ivet Sous Naasani, Biofabrication, 2023, 10.1088/1758-5090/ac9ff4

Purification and identification by immunological techniques of different isoforms of mammalian ATP diphosphohydrolases, Beaudoin, A. R., Dumas, F., Sevigny, J., Ecto-ATPases : recent progress on structure and function : [proceedings of the First International workshop on ecto-ATPases, held August 26-30, 1996, in Mar de Plata, Argentina], 1996, 10.1007/978-1-4615-5955-9_18

NTPDase7, Sévigny, J, UCSD-Nature Molecule Pages, 2006, 10.1038/mp.a003166.01

Characterization of a monoclonal antibody as the first specific inhibitor of human NTP diphosphohydrolase-3, Sevigny, Jean, Kirley, Terence L., Kuenzli, Beat, Tremblay, Alain, Fausther, Michel, Ivanenkov, Vasily V., Pelletier, Julie, Munkonda, Mercedes N., The FEBS Journal, 2009, 10.1111/J.1742-4658.2008.06797.X

NTPDase8, Sévigny, J, UCSD-Nature Molecule Pages, 2007, 10.1038/mp.a003955.01

CD39 may impact clopidrogrel pharmacodynamics, Sévigny, J, Martin-Satué, M, Fausther, M, Lecka, J, Austin journal of clinical immunology, 2014

NTPDase moduliert die Thrombusbildung und Typ1-Endothelzellaktivierung im experimentellen Ischämie-Reperfusions-Schaden des Dünndarmes*, S. C. Robson, P. Neuhaus, E. Kaczmarek, M. Imai, K. Enjyoji, J. B. Kruskal, J. Sévigny, Olaf Guckelberger, Deutsche Gesellschaft für Chirurgie, 2000, 10.1007/978-3-642-57295-1_53

Hydrolytically stable and selective P2Y(1/6) receptor agonists, Reiser, Georg, Sevigny, Jean, Lecka, Joanna, Weisman, Gary, Camden, Jean, Nahum, Vicky, Yelovitch, Shir, Eliahu, Shay E., Fischer, Bilha, 2008

Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors, Iqbal, J, Sevigny, J, Lecka, J, Khan, S, Nisa, ZU, Siddique, MN, Saeed, A, Ejaz, SA, Bioorganic chemistry, 2017, 10.1016/j.bioorg.2017.01.003

Synthesis and structure-activity relationship of uracil nucleotide derivatives towards the identification of human P2Y6 receptor antagonists, Fischer, B, Gendron, FP, Sevigny, J, Lecka, J, Danino, O, Nadel, Y, Arguin, G, Ethan, O, Meltzer, D, Bioorganic & medicinal chemistry, 2015, 10.1016/j.bmc.2015.07.004

Extracellular nucleosides and nucleotides regulate liver functions via a complex system of membrane proteins, Sevigny, J, Fausther, M, Comptes rendus biologies, 2011, 10.1016/j.crvi.2010.12.005

Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5'-(α or γ)-thio-(α,β- or β,γ)-methylenetriphosphate scaffold, Fischer, B, Sevigny, J, Senderowitz, H, Weisman, GA, Camden, J, Kenigsberg, S, Reiser, G, Forster, D, Gilad, Y, Ben-David, G, Lecka, J, Nadel, Y, Journal of medicinal chemistry, 2014, 10.1021/jm500196c

Expression of Plasma Membrane Bound Ectonucleotidases in the Male Murine Reproductive Tract, Sevigny, Jean, Robson, Simon, Fausther, Michel, Lavoie, Elise, Martin Satue, Mireia, 2009

P2Y(6)-induced release of ATP from the urothelium exerts a dual role in the human urinary bladder, Correia-de-Sa, P., Sevigny, J., Silva-Ramos, M., Ferreirinha, F., Correia, J., Silva, I., 2013

Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease, Jiang, ZG, Robson, SC, Sévigny, J, Müller, CE, Cheifetz, AS, Wu, Y, Stephan, H, hu, B, S, Longhi, MS, Mitsuhashi, S, Csizmadia, E, Yee, EU, Moss, AC, Feldbrügge, L, Journal of Crohn's & colitis, 2017, 10.1093/ecco-jcc/jjx058

UTP increases wound healing in the self assembled skin substitute (SASS), Marcia Wink, Véronique J. Moulin, Jean Sévigny, Liliana I. Sous Naasani, Journal of Cell Communication and Signaling, 2023, 10.1007/s12079-023-00725-2

Intestinal inflammation up-regulates the expression of the G protein-coupled receptor P2Y2 at the transcriptional level, -Pierre, Gendron, Fern, Sevigny, Jean, Dupuis, Andree-Anne, Lavoie, Elyse, Grbic, Djordje, Degagne, Emilie, 2008

Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous system, Zimmermann, H, Hanani, M, Hammer, K, Robson, SC, Sevigny, J, Braun, N, Glia, 2004, 10.1002/glia.10309

Fluorescent N2,N3-epsilon-adenine nucleoside and nucleotide probes: synthesis, spectroscopic properties, and biochemical evaluation, Fischer, B, Reiser, G, Ecke, D, Sévigny, J, Munkonda, MN, Lévesque, SA, Sharon, E, Chembiochem : a European journal of chemical biology, 2006, 10.1002/cbic.200600070

Induction of NTPDase1/CD39 by Reactive Microglia and Macrophages Is Associated With the Functional State During EAE, Laketa, D, Nedeljkovic, N, Pekovic, S, Sevigny, J, Savic, D, Bjelobaba, I, Milosevic, A, Lavrnja, I, Bozic, I, Jakovljevic, M, Frontiers in neuroscience, 2019, 10.3389/fnins.2019.00410

Epitope mapping in cell surface proteins by site-directed masking: defining the structural elements of NTPDase3 inhibition by a monoclonal antibody, Kirley, TL, Sevigny, J, Toyama, A, Crawford, PA, Ivanenkov, VV, Protein engineering, design & selection : PEDS, 2010, 10.1093/protein/gzq027

Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3, Picher, M, Sevigny, J, Ribeiro, CM, Pelletier, J, Fausther, M, American journal of physiology Lung cellular and molecular physiology, 2010, 10.1152/ajplung.00019.2010

Identification and immunolocalization of two isoforms of ATP-diphosphohydrolase (ATPDase) in the pig immune system, Beaudoin, AR, D'Orléans-Juste, P, Rousseau, E, Gendron, FP, Sévigny, J, Grondin, G, Benrezzak, O, Archives of biochemistry and biophysics, 1999, 10.1006/abbi.1999.1401

New insights into cytotoxic mechanisms of bozepinib against glioblastoma, Fabrício Figueiró, Joaquin María Campos, Ana Maria Oliveira Battastini, Jean Sévigny, Ana Conejo-García, Olga Cruz-López, Vera Lúcia Eifler-Lima, Gustavo Machado das Neves, Luciano Porto Kagami, Cesar Eduardo Jacintho Moritz, Juliete Nathali Scholl, Amanda de Fraga Dias, European Journal of Pharmaceutical Sciences, 2021, 10.1016/j.ejps.2021.105823

Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity, Muller, CE, Sevigny, J, Lecka, J, Baqi, Y, Fiene, A, The Analyst, 2015, 10.1039/c4an01694g

Expression of ecto-nucleoside triphosphate diphosphohydrolase 2 (NTPDase2) in non-myelinating Schwann cells, Zimmermann, H., Robson, S. C., Sevigny, J., Braun, N., 2001

Synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors, Iqbal, J, Sevigny, J, Lecka, J, Anbar, HS, Zaib, S, Jalil, S, Ullah, S, El-Gamal, MI, Semreen, MH, Bioorganic & medicinal chemistry, 2019, 10.1016/j.bmc.2019.04.031

Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer, Sévigny, J, Pelletier, J, Abid, SMA, Bano, S, Basharat, A, Iqbal, J, Medicinal chemistry (Shariqah (United Arab Emirates)), 2021, 10.2174/1573406416666200925141703

Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells, Ben Yebdri, F, Sevigny, J, Battastini, AM, Fonseca Moreira, JC, Bahrami, F, Pelletier, J, Bergamin, LS, Zanotto-Filho, A, Lavoie, EG, Fausther, M, Levesque, SA, Kukulski, F, Braganhol, E, Biochimica et biophysica acta, 2015, 10.1016/j.bbadis.2014.10.014

Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) – a promising target for the immunotherapy of cancer, Christa E. Müller, Gerd Bendas, Sang-Yong Lee, Björn Scheffler, Annamaria Naggi, Jean Sévigny, Julie Pelletier, Laura Schäkel, Christian Renn, Riham M. Idris, Katharina Sylvester, Michael S. Schmidt, Victoria J. Vaaßen, Salahuddin Mirza, H. J. Maximilian Schuh, Vittoria Lopez, Frontiers in Immunology, 2023, 10.3389/fimmu.2023.1173634

Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye, Mitchell, CH, Laties, AM, Zhang, X, Sheffield, VC, Zode, GS, Morrison, JC, Johnson, EC, Kaufman, PL, Gabelt, BT, Sevigny, J, Hu, H, Lu, W, Investigative ophthalmology & visual science, 2015, 10.1167/iovs.14-15891

Attenuated allergic airway inflammation in Cd39 null mice, Baudiß, K, Robson, SC, Sevigny, J, Pelletier, J, Sorichter, S, Zech, A, Boehlke, C, Cicko, S, Vieira, RP, Grimm, M, Durk, T, Muller, T, K Ayata, C, Idzko, M, Allergy, 2013, 10.1111/all.12119

Immortalization of Mesenchymal Stromal Cells by TERT Affects Adenosine Metabolism and Impairs their Immunosuppressive Capacity, Wink, MR, Lenz, G, Sévigny, J, Bertoni, APS, Iser, IC, Onzi, GR, de Campos, RP, Korb, VG, da Fontoura, DMS, Beckenkamp, LR, Stem cell reviews and reports, 2020, 10.1007/s12015-020-09986-5

Design, synthesis and biological evaluation of trinary benzocoumarin-thiazoles-azomethines derivatives as effective and selective inhibitors of alkaline phosphatase, Iqbal, J, Sevigny, J, Lecka, J, Larik, FA, Ashraf, Z, Saeed, A, Zaib, S, Shabir, G, Mahmood, A, Irum, H, Channar, PA, Bioorganic chemistry, 2019, 10.1016/j.bioorg.2019.103137

The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse, Finger, TE, Kinnamon, JC, Sevigny, J, Matsunami, H, Ishimaru, Y, Yang, R, Kataoka, S, Chemical senses, 2008, 10.1093/chemse/bjm083

Localization of CD39/vascular NTP diphosphohydrolase (NTPDase) in rat kidney, Robson, S. C., Sevigny, J., Tripp, S. R., Isaac, J., Kishore, B. K., 2002

The physiological role of NTPDases (ATP diphosphohydrolases) in mammals, Gendron, F. P., Fischer, B., Sévigny, J., Robson, S. C., Enjyoji, K., Grondin, G., Beaudoin, A. R., Ecto-ATPases and related ectonucleotidases : proceedings of the Second International Workshop on Ecto-ATPases and Related Ecotonucleotidases, held in Diepenbeek, Belgium, June 14-18, 1999, 1999

The ecto-nucleotidase NTPDase2 is selectively down-regulated in biliary fibrosis., Sévigny, Jean, 2003

Exacerbated intestinal inflammation in P2Y deficient mice is associated with Th17 activation, Sevigny, J, Aoudjit, F, Robaye, B, Pelletier, J, El Azreq, MA, Salem, M, Biochimica et biophysica acta Molecular basis of disease, 2019, 10.1016/j.bbadis.2019.06.019

Modulation of nucleoside [correction of nucleotide] triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection, Robson, SC, Bach, FH, Rosenberg, RD, Sévigny, J, Csizmadia, E, Lin, Y, Smith, RN, Enjyoji, K, Guckelberger, O, Takigami, K, Imai, M, Molecular medicine (Cambridge, Mass ), 1999

Synthesis, biological evaluation, and docking studies of new raloxifene sulfonate or sulfamate derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase, Iqbal, J, Sevigny, J, Pelletier, J, Anbar, HS, Omar, HA, Zaher, DM, Zaib, S, Jalil, S, Zaraei, SO, Ullah, S, El-Gamal, MI, European journal of medicinal chemistry, 2019, 10.1016/j.ejmech.2019.07.063

Synthesis of novel ()-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5'-nucleotidase inhibitors, Iqbal, J, Sevigny, J, Lecka, J, Shah, HS, Saeed, A, Larik, FA, Channar, PA, Hassan, S, Royal Society open science, 2018, 10.1098/rsos.180837

HIGHLY SELECTIVE AND POTENT NPP1 INHIBITORS BASED ON URIDINE-5'-P,-DITHIOPHOSPHATE ANALOGUES, Muller, Christa, Arad Uri, Moshe, Zelikman, Vadim, Nassir, Molhm, Fischer Hana, Bilha, Jean Sévigny, 2020

Purification of pancreas type-I ATP diphosphohydrolase and identification by affinity labelling with the 5'-p-fluorosulphonylbenzoyladenosine ATP analogue, Beaudoin, AR, Côté, YP, Sévigny, J, The Biochemical journal, 1995, 10.1042/bj3120351

Opposite deregulations of NTPDase1 (CD39) and NTPDase3 by cystic fibrosis, Sevigny, Jean, Ribeiro, Carla M., Pelletier, Julie, Fausther, Michel, Picher, Maryse, 2010

The ecto-ATPase NTPDase2 is associated with a subset of astrocytic cells in the germinal zones of the adult rodent brain., Sévigny, Jean, 2003

Impaired Expression of Ectonucleotidases in Ectopic and Eutopic Endometrial Tissue Is in Favor of ATP Accumulation in the Tissue Microenvironment in Endometriosis, Martin-Satue, M, Matias-Guiu, X, Ponce, J, Sevigny, J, a, I, Gomez de Ar, Barri, P, Tresserra, F, Coroleu, B, ez-Montoli, ME, Fern, Vidal, A, Trapero, C, International journal of molecular sciences, 2019, 10.3390/ijms20225532

Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5'-P-Dithiophosphate Analogues, Fischer, B, Sevigny, J, Senderowitz, H, Arguin, G, Gendron, FP, Sela, A, Simhaev, L, Pelletier, J, Zelikman, V, Journal of medicinal chemistry, 2018, 10.1021/acs.jmedchem.7b01906

Ca2+ responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice, Gulbransen, BD, Parpura, V, Sevigny, J, Leinninger, GM, Gomez-Suarez, RA, Fried, D, Grubisic, V, McClain, J, Gastroenterology, 2014, 10.1053/j.gastro.2013.10.061

Identification of small molecule sulfonic acids as ecto-5'-Nucleotidase inhibitors, Iqbal, J, Lecka, J, Sevigny, J, Saeed, A, Raza, R, Medicinal chemistry (Shariqah (United Arab Emirates)), 2012, 10.2174/1573406411208061133

Synthesis and biological evaluation of sulfamoyl benzamide derivatives as selective inhibitors for h-NTPDases, Abbas Hassan, Jamshed Iqbal, Jean Sévigny, Julie Pelletier, Saif Ullah, Zahid Hussain Zaigham, RSC Advances, 2023, 10.1039/D3RA03874B

Synthesis of Thieno[3,2-d]pyrimidine Derivatives through Sequential SNAr and Suzuki Reactions as Selective h-NTPDases Inhibitors, Abbas Hassan, Jamshed Iqbal, Jean Sévigny, Julia Pelletier, Farman Ullah, Haseen Ahmad, Sania Batool, Muhammad Uzair, Saif Ullah, Gohar Zaman, ChemMedChem, 2023, 10.1002/cmdc.202300165

Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents, Iqbal, J, Anbar, HS, Shehata, MK, Sevigny, J, Pelletier, J, El-Gamal, R, El-Gamal, MI, Ullah, S, European journal of medicinal chemistry, 2021, 10.1016/j.ejmech.2021.113339

Methotrexate up-regulates ecto-5'-nucleotidase/CD73 and reduces the frequency of T lymphocytes in the glioblastoma microenvironment, Battastini, AM, Pohlmann, AR, Guterres, SS, Sevigny, J, Pettenuzzo, LF, Moritz, CE, rey, EH, J, Mendes, FB, Rockenbach, L, Bergamin, LS, de Oliveira, CP, Figueiro, F, Purinergic signalling, 2016, 10.1007/s11302-016-9505-8

Leishmania infantum NTPDase1 and NTPDase2 play an important role in infection and nitric oxide production in macrophages, Juliana Lopes Rangel Fietto, Barbara Papadopoulou, Jean Sévigny, Julie Pelletier, Carole Dumas, Raphael de Souza Vasconcellos, Gustavo Costa Bressan, Tatiana Aparecida Oliveira, Luciana Ângelo de Souza, Victor Hugo Ferraz da Silva, Joice de Melo Agripino, Isadora Cunha Ribeiro, Walmir da Silva, Acta Tropica, 2023, 10.1016/j.actatropica.2022.106732

Diadenosine and diuridine poly(borano)phosphate analogues: synthesis, chemical and enzymatic stability, and activity at P2Y1 and P2Y2 receptors, Fischer, B, Reiser, G, Sévigny, J, Lévesque, SA, Tulapurkar, M, Nahum, V, Journal of medicinal chemistry, 2006, 10.1021/jm050955y

Regulation of liver fibrosis by P2Y nucleotide receptors, Wells, R. G., Gaca, M., Robson, S. C., Sevigny, J., Kruglov, E. A., Dranoff, J. A., 2004

Impaired hepatic regeneration in liver-specific insulin receptor knockout, Sevigny, Jean, 2000

Role of ecto-NTPDases on UDP-sensitive P2Y(6) receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women, Correia-de-Sá, P, Sévigny, J, Neves, JM, Freitas, R, Pelletier, J, Ferreirinha, F, Magalhães-Cardoso, MT, Costa, MA, Noronha-Matos, JB, Journal of cellular physiology, 2012, 10.1002/jcp.23014

NTPDASE1 modulates P2X7 responses in murine peritoneal macrophages, Sevigny, Jean, Kukulski, Filip, Levesque, Sebastien A., 2008

8-BuS-ATP derivatives as specific NTPDase1 inhibitors, Sevigny, J, Fischer, B, Kunzli, B, Poirier, D, Rousseau, E, d'Orleans-Juste, P, Martin-Satue, M, Cadot, C, Brosseau, JP, Munkonda, MN, Salem, M, Fausther, M, Gillerman, I, Lecka, J, British journal of pharmacology, 2013, 10.1111/bph.12135

Localization of CD39L1/vascular NTP diphosphohydrolase (NTPDase2) in murine kidney., Robson, S. C., Sevigny, J., Isaac, J., Kishore, B. K., 2002

Immunolocalization of ectonucleotidases along the rat nephron, Unwin, RJ, Sévigny, J, Shirley, DG, Vekaria, RM, American journal of physiology Renal physiology, 2006, 10.1152/ajprenal.00151.2005

CD39 as a caveolar-associated ectonucleotidase, Robson, SC, Csizmadia, E, Lengyel, K, Sevigny, J, Kaczmarek, E, Kittel, A, Biochemical and biophysical research communications, 1999, 10.1006/bbrc.1999.1254

P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide, Kelly, CP, Soltoff, SP, Communi, D, Sévigny, J, Robson, SC, Aboudola, S, Warny, M, The Journal of biological chemistry, 2001, 10.1074/jbc.M102568200

Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators, Martin, B, Maudsley, S, Sevigny, J, de Cabo, R, Chirdon, P, Wang, R, Cong, WN, Daimon, CM, Cai, H, The journals of gerontology Series A, Biological sciences and medical sciences, 2014, 10.1093/gerona/glt129

Cloning and characterization of the ecto-nucleotidase NTPDase3 from rat brain: Predicted secondary structure and relation to other members of the E-NTPDase family and actin, Braun, N, Sevigny, J, Pelletier, J, Zimmermann, H, Vorhoff, T, Purinergic signalling, 2005, 10.1007/s11302-005-6314-x

METHOD OF REDUCING ANGIOGENESIS, Hoshi, Tomokazu, Sundberg, Christian, Robson Simon, C., Jean Sévigny, 2003

Nucleotide signaling in quiescent and activated hepatic stellate cells., Wells, Rebecca G., Gaca, Mariana D. A., Sevigny, Jean, Kruglov, Emma A., Dranoff, Jonathan Ankin, 2003

Udp-Sensitive P2y6 Receptors Play a Dual Role in the Human Urinary Bladder Indirectly Via the Release of Atp from Urothelium, Correia-de-Sa, P., Sevigny, J., Ferreirinha, F., Correia, J., Monteiro, D., Silva, N., Vieira, C., Carneiro, I., Timoteo, M. A., Silva, I., Silva-Ramos, M., 2012

Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5'-Nucleotidase Inhibitors, Iqbal, J, Yaqub, M, Sevigny, J, Pelletier, J, Tahir, MN, Khan Jadoon, MS, Shafiq, Z, Ashraf, A, ACS medicinal chemistry letters, 2020, 10.1021/acsmedchemlett.0c00343

Ectonucleotidases in the kidney, Sevigny, J, Vekaria, RM, Shirley, DG, Purinergic signalling, 2009, 10.1007/s11302-009-9152-4

Mutagenesis of vascular ATP diphosphohydrolase, Robson, S. C., Bach, F. H., Beaudoin, A. R., Imai, M., Sevigny, J., Koziak, K., Siegel, J. B., Kaczmarek, E., Esch, J. S. A., 1997

Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile, Iqbal, J, Erben, MF, Sevigny, J, Lecka, J, Mahesar, PA, Larik, FA, Saeed, A, Ejaz, SA, Afzal, S, Channar, PA, European journal of medicinal chemistry, 2018, 10.1016/j.ejmech.2018.07.002

Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide, Muller, CE, Knowles, AF, Sevigny, J, Munkonda, MN, Scheiff, AB, Umbach, F, Iqbal, J, Brunschweiger, A, Journal of medicinal chemistry, 2008, 10.1021/jm800175e

Identification of a novel ecto-nucleoside triphoshphate diphosphohydrolase from the liver of the little skate Raja erinacea, Sevigny, J., Zarrella, K., Petell, L., Kruglov, E., Dranoff, J. A., 2002

Identification and isolation of a novel liver cell type expressing the ecto-nucleotidase NTPDase 2, Zimmerman, H., Braun, N., Robson, S. C., Sevigny, J., Kruglov, E. A., Dranoff, J. A., 2002

The nucleoside triphosphate diphosphohydrolase-1/CD39 is incorporated into human immunodeficiency type 1 particles, where it remains biologically active, Tremblay, MJ, Sevigny, J, Beaudoin, AR, Martin, G, Barat, C, Journal of molecular biology, 2007, 10.1016/j.jmb.2007.05.012

Ectonucleotidase Inhibitory and Redox Activity of Imidazole‐Based Organic Salts and Ionic Liquids, Fliur Macaev, Denis Prodius, Jean Sévigny, Joanna Lecka, Mariana Neamtu, Jamshed Iqbal, Sidra Hassan, Natalia Sucman, Veaceslav Boldescu, ChemMedChem, 2018, 10.1002/cmdc.201800520

Chemoselective Synthesis and Human Ecto‐5′‐nucleotidase Inhibitory Activity of 2‐Trifluoromethyl‐4,6‐diarylquinolines, Langer, P, Iqbal, J, Rodríguez, ET, Sévigny, J, Lecka, J, Ehlers, P, Hassan, S, Rivera, RP, ChemistrySelect, 2018, 10.1002/slct.201800917

Generation and characterization of polyclonal and monoclonal antibodies to human NTPDase2 including a blocking antibody, Sevigny, J, Gulbransen, B, Salem, M, Fausther, M, Delvalle, N, Agonsanou, H, Pelletier, J, Purinergic signalling, 2017, 10.1007/s11302-017-9561-8

P2Y(6)-induced release of ATP from the urothelium exerts a dual role in the human urinary bladder, Correia-de-Sa, P., Sevigny, J., Silva-Ramos, M., Ferreirinha, F., Correia, J., Silva, I., The FEBS Journal, 2013

Beneficial effects of CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 in murine intestinal ischemia-reperfusion injury, Robson, SC, Kruskal, JB, Enjyoji, K, Kaczmarek, E, Imai, M, Sévigny, J, Sun, XF, Guckelberger, O, Thrombosis and haemostasis, 2004, 10.1160/TH03-06-0373

Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques, Beaudoin, AR, Grondin, G, Levesque, FP, Sévigny, J, Biochimica et biophysica acta, 1997, 10.1016/s0304-4165(96)00079-7

The P2 receptor antagonist PPADS abrogates LPS-induced neutrophil migration in the murine air pouch via inhibition of MIP-2 and KC production, Sevigny, J, Martin-Satue, M, Levesque, SA, Bahrami, F, Ben Yebdri, F, Kukulski, F, Molecular immunology, 2010, 10.1016/j.molimm.2009.09.037

Stomach-derived human insulin-secreting organoids restore glucose homeostasis, Qiao Zhou, Jean Sévigny, David T. Breault, Jian Zhu, Hyunkee Kim, Jiaqi Lu, Christoph Pertl, Sanlan Li, Jonathan L. Colarusso, Ying Lan, Jiaoyue Zhang, Wei Gu, Xiaofeng Huang, Nature Cell Biology, 2023, 10.1038/s41556-023-01130-y

The Purinergic Receptor P2X4 Promotes Th17 Activation and the Development of Arthritis, Aoudjit, F, Sévigny, J, Fortin, PR, Salem, M, Abderrazak, A, Zhao, C, Hamoudi, C, Journal of immunology (Baltimore, Md : 1950), 2022, 10.4049/jimmunol.2100550

17β-Estradiol upregulates ecto-5'-nucleotidase (CD73) in hippocampal synaptosomes of female rats through action mediated by estrogen receptor-α and -β, Grkovic, I, Nedeljkovic, N, Horvat, A, Sevigny, J, Stanojlovic, M, Martinovic, J, Drakulic, D, Zaric, M, Mitrovic, N, Neuroscience, 2016, 10.1016/j.neuroscience.2016.03.022

Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants, Egan, JM, Maudsley, S, Tschop, MH, Sevigny, J, Smith, RG, Sun, Y, Ji, S, White, CM, Kim, W, Martin, B, Shin, YK, PloS one, 2010, 10.1371/journal.pone.0012729

Identification of hydrolytically stable and selective P2Y(1) receptor agonists, Fischer, Bilha, Gelinas, Sylvie, Sevigny, Jean, Weisman, Gary A., Lecka, Joanna, Camden, Jean, Elyahu, Shay, Purinergic Signalling, 2008, 10.1016/J.EJMECH.2008.07.015

NTPDase1 and NTPDase2 immunolocalization in mouse cochlea: Implications for regulation of P2 receptor signaling, Housley, GD, Robson, SC, Sevigny, J, Thorne, PR, Vlajkovic, SM, Journal of Histochemistry & Cytochemistry, 2002, 10.1177/002215540205001102

Development of a selective and highly sensitive fluorescence assay for nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39), Muller, CE, Sevigny, J, Stephan, H, Pelletier, J, Mirza, S, Geiss, J, Namasivayam, V, Luo, X, Lee, SY, The Analyst, 2018, 10.1039/c8an01108g

Changes in ecto-nucleotidases in murine and human endometria along the female cycle, Martin Satue, Mireia, Sevigny, J., Torrejon-Escribano, B., Lavoie, E. G., Ponce, J., Vidal, A., Taco-Sanchez, M. R., Aliagas Marin, Elisabet, 2010

Imatinib mesylate affects extracellular ATP catabolism and expression of NTPDases in a chronic myeloid leukemia cell line, Pilger, DA, Buffon, A, Wink, MR, Sevigny, J, Beckenkamp, LR, Beckenkamp, A, Vianna, DRB, Willig, JB, Purinergic signalling, 2020, 10.1007/s11302-019-09686-x

A highly sensitive CE-UV method with dynamic coating of silica-fused capillaries for monitoring of nucleotide pyrophosphatase/phosphodiesterase reactions, Muller, CE, Sevigny, J, Levesque, SA, Iqbal, J, Electrophoresis, 2008, 10.1002/elps.200800013

Distribution of different ATP-diphosphohydrolase isoforms in mammalian organs, Sevigny, J., Grondin, G., Beaudoin, A. R., Ecto-ATPases : recent progress on structure and function : [proceedings of the First International workshop on ecto-ATPases, held August 26-30, 1996, in Mar de Plata, Argentina], 1997, 10.1007/978-1-4615-5955-9_5

NTPDase1 governs P2X7-dependent functions in murine macrophages, Sevigny, J, Robson, SC, Enjyoji, K, Kukulski, F, Levesque, SA, European journal of immunology, 2010, 10.1002/eji.200939741

Identification of the catalytic subunit of the bovine lung ATP-diphosphohydrolase, Beaudoin, A. R., Picher, M., Sévigny, Jean, 1995

Expression of ecto-ATPase NTPDase2 in human dental pulp, Ren, YF, Dirksen, RT, Malmstrom, HS, Sevigny, J, Fausther, M, Pelletier, J, Wang, Q, Yu, L, Liu, X, Journal of dental research, 2012, 10.1177/0022034511431582

Identification and characterization of CD39/vascular ATP diphosphohydrolase, Robson, SC, Bach, FH, Beaudoin, AR, Anrather, J, Siegel, JB, Sévigny, J, Koziak, K, Kaczmarek, E, The Journal of biological chemistry, 1996, 10.1074/jbc.271.51.33116

Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers, Asahina, K, Sevigny, J, French, SW, Wang, KS, Zagory, JA, Li, Y, Lua, I, Journal of hepatology, 2016, 10.1016/j.jhep.2016.01.010

NTPDase3 is the principal ectonucleotidase in both nociceptors and low threshold mechanoreceptors, Molliver, D. C., Sevigny, J., Lavoie, E. G., Vongtau, H. O., 2011

Extracellular nucleotides in smooth muscle contraction, Jean Sévigny, Romuald Brice Babou Kammoe, Biochemical Pharmacology, 2024, 10.1016/j.bcp.2023.116005

The endothelial P2Y2 receptor mediates LPS-induced neutrophil transendothelial migration, Sevigny, Jean, Tremblay, Alain, Fausther, Michel, Ben Yebdri, Fethia, Kukulski, Filip, Purinergic Signalling, 2008

Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis, Robson, SC, Popov, YV, Schmelzle, M, Sevigny, J, Vaid, KA, Rothweiler, S, Yee, EU, Tran, S, Mitsuhashi, S, Csizmadia, E, Jiang, ZG, Feldbrugge, L, Purinergic signalling, 2018, 10.1007/s11302-017-9590-3

Palladium-catalyzed synthesis and nucleotide pyrophosphatase inhibition of benzo[4,5]furo[3,2-]indoles, Langer, P, Iqbal, J, Ehlers, P, Sevigny, J, Lecka, J, Villinger, A, Ullah, S, Do, HH, Beilstein journal of organic chemistry, 2019, 10.3762/bjoc.15.276

HIGHLY SELECTIVE AND POTENT NPP1 INHIBITORS BASED ON URIDINE-5'-P,-DITHIOPHOSPHATE ANALOGUES, Muller, Christa, Arad Uri, Moshe, Zelikman, Vadim, Nassir, Molhm, Fischer Hana, Bilha, Jean Sévigny, 2022

Nucleoside-(5'→P) methylenebisphosphonodithioate analogues: synthesis and chemical properties, Fischer, B, Sevigny, J, Amir, A, Lecka, J, Nadel, Y, Meltzer, D, The Journal of organic chemistry, 2013, 10.1021/jo400931n

Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes, Robson, SC, Battastini, AM, Sévigny, J, Libermann, TA, Zerbini, LF, Lenz, G, Tamajusuku, AS, Braganhol, E, Wink, MR, Neuroscience, 2006, 10.1016/j.neuroscience.2005.11.039

Histamine induces ATP release from human subcutaneous fibroblasts, via pannexin-1 hemichannels, leading to Ca2+ mobilization and cell proliferation, Correia-de-Sa, P, Sevigny, J, Ferreirinha, F, Magalhaes-Cardoso, MT, Costa, C, Costa, MA, Certal, M, Paramos-de-Carvalho, D, Pinheiro, AR, The Journal of biological chemistry, 2013, 10.1074/jbc.M113.460865

Co-expression of ecto-5 '-nucleotidase/CD73 with NTPDases in the liver distinctly regulates adenosine formation, Sevigny, Jean, Zimmermann, Herbert, Lecka, Joanna, Fausther, Michel, 2008

The ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in human endometrium: a novel marker of basal stroma and mesenchymal stem cells, Martin-Satue, M, Matias-Guiu, X, Coroleu, B, Ponce, J, Sevigny, J, Rodriguez-Martinez, A, Vidal, A, Trapero, C, Purinergic signalling, 2019, 10.1007/s11302-019-09656-3

C-terininal splicing of NTPDase2 provides distinctive catalytic properties, cellular distribution and enzyme regulation, Thorne, PR, Soeller, C, Sevigny, J, Robson, SC, Zimmermann, H, Braun, N, Housley, GD, Vlajkovic, SM, Wang, CJF, Biochemical Journal, 2005, 10.1042/BJ20040852

Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39, Muller, CE, Bendas, G, Alban, S, Sevigny, J, Lee, SY, Pelletier, J, Renn, C, Mirza, S, Schmidt, MS, Schuh, HJM, Schakel, L, Lopez, V, Marine drugs, 2021, 10.3390/md19020051

Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A receptor as potential antitumor agents, Colotta, V, Varani, K, Sevigny, J, Guilbaud, A, ie, M, Sarl, Espindola Gelsleichter, N, Lopes Rangel Fietto, J, Pelletier, J, Pasquini, S, Vincenzi, F, Catarzi, D, Varano, F, Bioorganic & medicinal chemistry letters, 2020, 10.1016/j.bmcl.2020.127067

The ecto-nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor-dependent vasorelaxation, Sevigny, J, D'Orleans-Juste, P, Furstenau, CR, Kauffenstein, G, British journal of pharmacology, 2010, 10.1111/j.1476-5381.2009.00566.x

Purification, caracterisation et localisation des ATP diphosphohydrolases de mammiferes, et clonage de l'ADNc, Sevigny, Jean, 1997

Noise exposure induces up-regulation of ecto-nucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea, Thorne, PR, Wang, CJH, Sevigny, J, Robson, SC, Munoz, DJB, Housley, GD, Vlajkovic, SM, Neuroscience, 2004, 10.1016/J.NEUROSCIENCE.2004.04.023

BORANOPHOSPHATE DERIVATIVES FOR THE TREATMENT OF OSTEOARTHRITIS, Lecka, Joanna, Eliahu, Shay, Fischer, Bilha, Jean Sévigny, 2012

ATP-diphosphohydrolases, process of purification thereof and process of producing thereof by recombinant technology, Beaudoin Adrien, R., Jean Sévigny, 2004

Nucleoside triphosphate diphosphohydrolase (NTPDASE 8) and uses thereof, Jean Sévigny, 2005

Loss of vascular expression of nucleoside triphosphate diphosphohydrolase-1/CD39 in hypertension, Kauffenstein, G, Henrion, D, Sevigny, J, Robson, SC, Ryffel, B, Nascimento, DC, Martin, L, Guihot, AL, Favre, J, Merot, J, Delneste, Y, Caillon, A, Tabiasco, J, Roy, C, Purinergic signalling, 2018, 10.1007/s11302-017-9597-9

ATP diphosphohydrolase (CD39) gene therapy for inflammatory or thrombotic conditions and transplantation and means therefor, BEAUDOIN ADRIEN R., ROBSON SIMON, BACH FRITZ H., Jean Sévigny, 2004

Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8, Sevigny, J, Kirley, TL, Robson, SC, Knowles, AF, Bigonnesse, F, Lecka, J, Lavoie, EG, Levesque, SA, Kukulski, F, Purinergic signalling, 2005, 10.1007/s11302-005-6217-x

Correction to: Identification of adenine-N9-(methoxy)ethyl-β-bisphosphonate as NPP1 inhibitor attenuates NPPase activity in human osteoarthritic chondrocytes, Fischer, B, Muller, CE, Sevigny, J, Pelletier, J, Zimmermann, H, Renn, SMC, Journo, S, Lee, SY, Arad, U, Nassir, M, Purinergic signalling, 2019, 10.1007/s11302-019-09671-4

Inhibition of vascular ectonucleotidase activities by the pro-drugs ticlopidine and clopidogrel favours platelet aggregation, Sevigny, J, Rana, MS, Lecka, J, British journal of pharmacology, 2010, 10.1111/j.1476-5381.2010.00951.x

Coexpression of ecto-5'-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver, Sevigny, J, Dranoff, JA, Sheung, N, Pelletier, J, Kauffenstein, G, Soliman, E, Lecka, J, Fausther, M, American journal of physiology Gastrointestinal and liver physiology, 2012, 10.1152/ajpgi.00165.2011

Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases, Sevigny, J, Bigonnesse, F, Lecka, J, Lavoie, EG, Levesque, SA, British journal of pharmacology, 2007, 10.1038/sj.bjp.0707361

Investigation of quinoline-4-carboxylic acid as a highly potent scaffold for the development of alkaline phosphatase inhibitors: synthesis, SAR analysis and molecular modelling studies, Iqbal, J, Sévigny, J, Millan, JL, Lecka, J, Hameed, S, Ibrar, A, Ejaz, SA, Ali Shah, SJ, Khan, I, RSC advances, 2015, 10.1039/c5ra12455g

Characterization of a novel ATP diphosphohydrolase/CD39-like protein, Sévigny, Jean, 1999

Purification and immunohistochemical localization of the ATP diphosphohydrolase in bovine lungs, Beaudoin, AR, Grondin, G, Picher, M, Sévigny, J, The American journal of physiology, 1997, 10.1152/ajplung.1997.272.5.L939

Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation, Robson, SC, Zimmermann, H, Imai, M, Qawi, I, Csizmadia, E, Guckelberger, O, Braun, N, Sundberg, C, Sévigny, J, Blood, 2002, 10.1182/blood.v99.8.2801

Regulation of insulin secretion by NTPDase3, Sevigny, Jean, Fausther, Michel, Lavoie, Elise G., 2008

Découvrez nos professeurs et professeures!

Jean Sévigny

Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie

Santé cardiovasculaire, respiratoire et métabolisme

Transfert des connaissances

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite

Maladies infectieuses et immunitaires

Nutrition et métabolisme

Santé circulatoire et respiratoire

Projets de recherche

Publications

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Encadrement d'étudiant(e)s pour les programmes suivants :

Biologie cellulaire et moléculaire

Médecine moléculaire

Microbiologie-immunologie

Sciences cliniques et biomédicales

Disponibilité d'encadrement d'étudiant(e)s

Direction et personnes-ressources