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Jean-Yves Masson

Professeur titulaire

Jean-Yves Masson
jean-yves.masson@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Cancer du sein
  • Cancer héréditaire
  • Chimiothérapie
Génétique humaine
  • Dépistage génétique des maladies
  • Dommages et réparation du génome
Cellulaire
Organisation et fonctions biologiques

Projets de recherche

  • Roles of the tumor suppressor PALB2 at the intersection of DNA repair and synthetic lethal strategies in cancer - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2024-10-01 au 2029-09-30
  • Characterization of novel breast cancer susceptibility genes through large-scale targeted sequencing and functional assays. - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-04-01 au 2029-03-31
  • Emerging roles of Zinc Finger PAR-Interacting Proteins (ZIPPs) in DNA double-strand break (DSB) repair: implications in PARPi therapy - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-04-01 au 2029-03-31
  • Canada Research Chair in DNA repair and Cancer Therapeutics - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2027-06-30
  • Caractérisation de nouveaux gènes de susceptibilité au cancer du sein - Ministère de l'Économie et de l'Innovation et de l'énergie - Programme de soutien aux organismes de recherche et d’innovation (PSO) - International Volet 2C(Ancien PSR-SIIRI), co-chercheur - 2024-02-15 au 2027-04-01
  • Unveiling the roles of Poly(ADP)ribose Glycohydrolase (PARG) in DNA repair and cancer - Société de recherche sur le cancer - Subvention de fonctionnement, chercheur principal - 2024-09-01 au 2026-08-31
  • Réseau de recherche sur le cancer (RRCancer) - Fonds de recherche du Québec - Santé - ONCOPOLE EMC2: Équipes multi-institutionnelles contre le cancer, chercheur principal - 2023-04-01 au 2026-03-31
  • Decoding the DNA double-strand break repair pathways: from mechanistic insights to human genome instability diseases - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2018-07-01 au 2025-06-30
  • Poly(ADP-ribose) writers, readers, and erasers: Functions in DNA double-strand break repair and synthetic lethality - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-10-01 au 2024-09-30
  • Fonds de cancérologie et ses fonds liés - Fondation de l'Université Laval - 2005-04-01 au 2024-04-30
  • Tumor biobanking was supported by the Banque de tissus et de données en cancers solides of the Réseau de recherche sur le cancer (RRCancer)...The RRCancer is funded by the Oncopole...de l'Économie, de l'Innovation et de l'Énergie du Québec. - Fonds de recherche du Québec - Santé - ONCOPOLE EMC2: Équipes multi-institutionnelles contre le cancer, chercheur principal - 2023-04-01 au 2024-03-31
  • The contribution of RAD51C and RAD51D to breast and ovarian cancer - National Institute of Health (USA) - Subvention de recherche, Mayo Clinic Rochester, co-chercheur - 2021-05-01 au 2023-04-30
  • Grand prix scientifique - Fondation du cancer du sein du Québec - Prix d'excellence - Grand prix scientifique, chercheur principal - 2022-04-01 au 2023-03-31
  • Characterization of HR-Killer1 and identification of small molecules for cancer therapy and enhanced gene editing using CRISPR/Cas9-based DNA repair strategies - Instituts de recherche en santé du Canada - Subvention Projet, Dalhousie University, co-chercheur - 2018-04-01 au 2023-03-31
  • Investigating the Role of RECQL in Breast Cancer Susceptibility - Instituts de recherche en santé du Canada - Subvention Projet, University of Toronto, co-chercheur - 2017-04-01 au 2022-03-31
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II) - Regroupement de compagnies et corporations canadiennes, Fondation du CHU de Québec, Génome Québec, Ministère de la santé (Ontario), Ministère de l'Économie, de la Science et de l'Innovation, Instituts de recherche en santé du Canada, Fondation du cancer du sein du Québec, Génome Canada - Projets de recherche appliquée à grande échelle - Large-Scale Applied Research Project, co-chercheur - 2017-11-01 au 2022-03-31

Publications

  • DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions., , NAR cancer, 2020, 10.1093/narcan/zcaa028
  • ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair., , EMBO reports, 2012, 10.1038/embor.2011.243
  • SUMOylation mediates CtIP's functions in DNA end resection and replication fork protection., , Nucleic acids research, 2021, 10.1093/nar/gkaa1232
  • CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection., , Nucleic acids research, 2019, 10.1093/nar/gkz784
  • Identification and purification of two distinct complexes containing the five RAD51 paralogs., , Genes & development, 2001, 10.1101/gad.947001
  • Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids., , The EMBO journal, 2019, 10.15252/embj.2018100986
  • Role of BRCA2 in control of the RAD51 recombination and DNA repair protein., , Molecular cell, 2001, 10.1016/s1097-2765(01)00175-7
  • Missense PALB2 germline variant disrupts nuclear localization of PALB2 in a patient with breast cancer., , Familial cancer, 2020, 10.1007/s10689-020-00163-8
  • Schizosaccharomyces pombe apn1 encodes a homologue of the Escherichia coli endonuclease IV family of DNA repair proteins., , Biochimica et biophysica acta, 1998, 10.1016/s0167-4781(97)00160-7
  • A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene., , Genome medicine, 2021, 10.1186/s13073-021-00998-5
  • The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy., , Journal of cell science, 2012, 10.1242/jcs.114595
  • Addressing the dark matter of gene therapy: technical and ethical barriers to clinical application., , Human genetics, 2021, 10.1007/s00439-021-02272-5
  • Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection., , Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1806513115
  • Lysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress., , Oncotarget, 2017, 10.18632/oncotarget.18070
  • A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation., , EMBO molecular medicine, 2018, 10.15252/emmm.201809172
  • The identification of FANCD2 DNA binding domains reveals nuclear localization sequences., , Nucleic acids research, 2017, 10.1093/nar/gkx543
  • Deciphering the function of lactococcal phage ul36 Sak domains., , Journal of structural biology, 2009, 10.1016/j.jsb.2009.12.021
  • XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes., , Molecular cell, 2003, 10.1016/s1097-2765(03)00132-1
  • Double-strand break repair in human cells., , Cold Spring Harbor symposia on quantitative biology, 2000, 10.1101/sqb.2000.65.315
  • Human Dmc1 protein binds DNA as an octameric ring., , Proceedings of the National Academy of Sciences of the United States of America, 1999, 10.1073/pnas.96.19.10684
  • Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation., , Nature communications, 2019, 10.1038/s41467-019-08859-x
  • Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2., , Nature communications, 2019, 10.1038/s41467-019-13194-2
  • [A new role for arginine methylation in DNA repair]., , Medecine sciences : M/S, 2005, 10.1051/medsci/2005216-7579
  • Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities., , Methods in enzymology, 2018, 10.1016/bs.mie.2017.11.030
  • [Functions of PALB2 and BRCA2 tumor suppressors in DNA double-strand break repair]., , Medecine sciences : M/S, 2013, 10.1051/medsci/2013293017
  • The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair., , Molecular and cellular biology, 2006, 10.1128/mcb.26.2.402-412.2006
  • The transcriptional activator Imp2p maintains ion homeostasis in Saccharomyces cerevisiae., , Genetics, 1998, 10.1093/genetics/149.2.893
  • The meiosis-specific recombinase hDmc1 forms ring structures and interacts with hRad51., , The EMBO journal, 1999, 10.1093/emboj/18.22.6552
  • A requirement for polymerized actin in DNA double-strand break repair., , Nucleus (Austin, Tex.), 2012, 10.4161/nucl.21055
  • Functional mitochondria are essential for Saccharomyces cerevisiae cellular resistance to bleomycin., , Current genetics, 1996, 10.1007/s002940050133
  • Structure and function of phage p2 ORF34(p2), a new type of single-stranded DNA binding protein., , Molecular microbiology, 2009, 10.1111/j.1365-2958.2009.06844.x
  • Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells., , Nucleic acids research, 2021, 10.1093/nar/gkab1173
  • PALB2 self-interaction controls homologous recombination., , Nucleic acids research, 2012, 10.1093/nar/gks807
  • The Rad51 and Dmc1 recombinases: a non-identical twin relationship., , Trends in biochemical sciences, 2001, 10.1016/s0968-0004(00)01742-4
  • Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution., , Life science alliance, 2020, 10.26508/lsa.202000762
  • E4F1 is a master regulator of CHK1-mediated functions., , Cell reports, 2015, 10.1016/j.celrep.2015.03.019
  • Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing., , Nucleic acids research, 2019, 10.1093/nar/gky519
  • A Saccharomyces cerevisiae mutant defines a new locus essential for resistance to the antitumour drug bleomycin., , Canadian journal of microbiology, 1996, 10.1139/m96-105
  • Coupling of Homologous Recombination and the Checkpoint by ATR., , Molecular cell, 2017, 10.1016/j.molcel.2016.12.007
  • A new chitosanase gene from a Nocardioides sp. is a third member of glycosyl hydrolase family 46., , Microbiology (Reading, England), 1995, 10.1099/13500872-141-10-2629
  • The Schizosaccharomyces pombe spqM gene is a new member of the Qm transcription factor family., , Gene, 1996, 10.1016/0378-1119(95)00853-5
  • Replication Protein A Availability during DNA Replication Stress Is a Major Determinant of Cisplatin Resistance in Ovarian Cancer Cells., , Cancer research, 2018, 10.1158/0008-5472.can-18-0618
  • Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I)., , Journal of personalized medicine, 2021, 10.3390/jpm11060511
  • Fission yeast rad51 and dmc1, two efficient DNA recombinases forming helical nucleoprotein filaments., , Molecular and cellular biology, 2005, 10.1128/mcb.25.11.4377-4387.2005
  • The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination., , Nature structural & molecular biology, 2005, 10.1038/nsmb923
  • FANCD2: A DNA binding protein regulated by MRE11-RAD50-NBS1., , Cell cycle (Georgetown, Tex.), 2010, 10.4161/cc.9.2.10492
  • Exploring the roles of PALB2 at the crossroads of DNA repair and cancer., , The Biochemical journal, 2014, 10.1042/bj20140208
  • Chromatin remodeling and the maintenance of genome integrity., , Biochimica et biophysica acta, 2004, 10.1016/j.bbaexp.2003.10.016
  • Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks., , Cell reports, 2014, 10.1016/j.celrep.2014.01.009
  • Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy., , Trends in molecular medicine, 2005, 10.1016/j.molmed.2005.08.003
  • Conformational changes modulate the activity of human RAD51 protein., , Journal of molecular biology, 2004, 10.1016/j.jmb.2004.02.022
  • Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase inhibitors (PARPis): targeted therapy., , Journal of translational medicine, 2020, 10.1186/s12967-020-02613-4
  • Saccharomyces cerevisiae DNA repair processes: an update., , Molecular and cellular biochemistry, 1996, 10.1007/bf00225884
  • Recovery of deficient homologous recombination in Brca2-depleted mouse cells by wild-type Rad51 expression., , DNA repair, 2008, 10.1016/j.dnarep.2008.10.002
  • Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair., , Proceedings of the National Academy of Sciences of the United States of America, 2021, 10.1073/pnas.2019408118
  • Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells., , Investigational new drugs, 2011, 10.1007/s10637-010-9626-9
  • The Tumor Suppressor PALB2: Inside Out., , Trends in biochemical sciences, 2019, 10.1016/j.tibs.2018.10.008
  • A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development., , PloS one, 2011, 10.1371/journal.pone.0015834
  • MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts., , Nature communications, 2019, 10.1038/s41467-019-12271-w
  • Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells., , eLife, 2019, 10.7554/elife.44063
  • RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability., , The Journal of cell biology, 2017, 10.1083/jcb.201703168
  • FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders., , Journal of Huntington's disease, 2021, 10.3233/jhd-200448
  • ZNF768 links oncogenic RAS to cellular senescence., , Nature communications, 2021, 10.1038/s41467-021-24932-w
  • PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks., , Nucleic acids research, 2012, 10.1093/nar/gks798
  • Exploring the multiple facets of the meiotic recombinase Dmc1., , BioEssays : news and reviews in molecular, cellular and developmental biology, 2004, 10.1002/bies.20150
  • A glycine-arginine domain in control of the human MRE11 DNA repair protein., , Molecular and cellular biology, 2008, 10.1128/mcb.02025-07
  • DNA repair pathways in trypanosomatids: from DNA repair to drug resistance., , Microbiology and molecular biology reviews : MMBR, 2014, 10.1128/mmbr.00045-13
  • Special AT-rich Sequence-binding Protein 1 (SATB1) Functions as an Accessory Factor in Base Excision Repair., , The Journal of biological chemistry, 2016, 10.1074/jbc.m116.735696
  • Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis., , Nature communications, 2021, 10.1038/s41467-021-27306-4
  • Stimulation of fission yeast and mouse Hop2-Mnd1 of the Dmc1 and Rad51 recombinases., , Nucleic acids research, 2007, 10.1093/nar/gkm174
  • Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks., , Journal of medicinal chemistry, 2012, 10.1021/jm3006492
  • Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability., , The Journal of biological chemistry, 2002, 10.1074/jbc.m201402200
  • A DNA repair-independent role for alkyladenine DNA glycosylase in alkylation-induced unfolded protein response., , Proceedings of the National Academy of Sciences of the United States of America, 2022, 10.1073/pnas.2111404119
  • Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response., , Molecular and cellular biology, 2013, 10.1128/mcb.01256-12
  • Partners apart: Smc6-independent DNA binding activity of Smc5 on single-strand DNA., , Cell cycle (Georgetown, Tex.), 2011, 10.4161/cc.10.7.15212
  • BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma., , Genes & development, 2019, 10.1101/gad.314633.118
  • Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B., , European journal of medicinal chemistry, 2015, 10.1016/j.ejmech.2015.09.012
  • Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches., , Biochimie, 2019, 10.1016/j.biochi.2019.09.016
  • FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability., , Cell reports, 2021, 10.1016/j.celrep.2021.110078
  • A global functional analysis of missense mutations reveals two major hotspots in the PALB2 tumor suppressor., , Nucleic acids research, 2019, 10.1093/nar/gkz780
  • Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1., , Nature communications, 2018, 10.1038/s41467-018-06854-2
  • CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage., , Nucleic acids research, 2012, 10.1093/nar/gks222
  • Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation., , Journal of medical genetics, 2020, 10.1136/jmedgenet-2019-106368
  • Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks., , Nature communications, 2019, 10.1038/s41467-019-10741-9
  • Detection of the HIV-1 minus-strand-encoded antisense protein and its association with autophagy., , Journal of virology, 2013, 10.1128/jvi.00225-13
  • Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging., , Journal of visualized experiments : JoVE, 2021, 10.3791/62553
  • HELB Is a Feedback Inhibitor of DNA End Resection., , Molecular cell, 2016, 10.1016/j.molcel.2015.12.013
  • The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice., , Nature cell biology, 2015, 10.1038/ncb3259
  • Normal processing of AP sites in Apn1-deficient Saccharomyces cerevisiae is restored by Escherichia coli genes expressing either exonuclease III or endonuclease III., , Molecular microbiology, 1997, 10.1046/j.1365-2958.1997.3841748.x
  • Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair., , Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1309085110
  • Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum., , Nucleic acids research, 2015, 10.1093/nar/gkv118
  • MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends., , Cell reports, 2021, 10.1016/j.celrep.2020.108565
  • SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice., , The EMBO journal, 2018, 10.15252/embj.2018100158
  • A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation., , eLife, 2017, 10.7554/elife.20922
  • Characterization of amino acid substitutions that severely alter the DNA repair functions of Escherichia coli endonuclease IV., , Biochemistry, 1999, 10.1021/bi9824083
  • Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins., , Journal of molecular biology, 2000, 10.1006/jmbi.2000.4180
  • GST-His purification: a two-step affinity purification protocol yielding full-length purified proteins., , Journal of visualized experiments : JoVE, 2013, 10.3791/50320
  • A Saccharomyces cerevisiae phleomycin-sensitive mutant, ph140, is defective in the RAD6 DNA repair gene., , Canadian journal of microbiology, 1996, 10.1139/m96-164
  • The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants., , Molecular and cellular biology, 1996, 10.1128/mcb.16.5.2091
  • Limiting the DNA Double-Strand Break Resectosome for Genome Protection., , Trends in biochemical sciences, 2020, 10.1016/j.tibs.2020.05.003
  • Functional characterization of 84 PALB2 variants of uncertain significance., , Genetics in medicine : official journal of the American College of Medical Genetics, 2019, 10.1038/s41436-019-0682-z
  • Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif., , Nucleic acids research, 2017, 10.1093/nar/gkx011
  • Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism., , PLoS genetics, 2016, 10.1371/journal.pgen.1006117
  • A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2., , Nucleic acids research, 2019, 10.1093/nar/gkz514
  • XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase., , Nucleic acids research, 2021, 10.1093/nar/gkab785
  • The microRNA pathway controls germ cell proliferation and differentiation in C. elegans., , Cell research, 2012, 10.1038/cr.2012.31
  • A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo., , Nature genetics, 2020, 10.1038/s41588-019-0575-8
  • Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination., , Nature structural & molecular biology, 2010, 10.1038/nsmb.1915
  • The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation., , Cell research, 2011, 10.1038/cr.2011.128
  • CRISPR/Cas9 Gene Editing: From Basic Mechanisms to Improved Strategies for Enhanced Genome Engineering In Vivo., , Current gene therapy, 2017, 10.2174/1566523217666171122094629
  • Complex formation by the human RAD51C and XRCC3 recombination repair proteins., , Proceedings of the National Academy of Sciences of the United States of America, 2001, 10.1073/pnas.111005698
  • DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells., , Nature, 2018, 10.1038/s41586-018-0670-5
  • Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction., , Nucleic acids research, 2016, 10.1093/nar/gkw921
  • Effect of regulatory sequence substitution on chitosanase production from a cloned gene in Streptomyces lividans, , In: Chitin World. Ed. Z. Karnicki, M.M. Brzezki, J. Dutkiewicz & A. Wojtasz-Pajak, Editors, Elsevier Applied Science, Amsterdam., 1995
  • PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites., , The Journal of biological chemistry, 2007, 10.1074/jbc.m706734200
  • Animal models of Fanconi anemia: A developmental and therapeutic perspective on a multifaceted disease., , Seminars in cell & developmental biology, 2021, 10.1016/j.semcdb.2020.11.010
  • Molecular Determinant of DIDS Analogs Targeting RAD51 Activity., , Molecules (Basel, Switzerland), 2021, 10.3390/molecules26185460
  • Reprogramming cellular events by poly(ADP-ribose)-binding proteins., , Molecular aspects of medicine, 2012, 10.1016/j.mam.2012.12.005
  • Lactococcal phage p2 ORF35-Sak3 is an ATPase involved in DNA recombination and AbiK mechanism., , Molecular microbiology, 2011, 10.1111/j.1365-2958.2011.07561.x
  • Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions., , The Journal of biological chemistry, 2013, 10.1074/jbc.m113.525345
  • Factors governing efficient chitosanase production by recombinant Streptomyces lividans strains carrying the cloned chs gene from Streptomyces N174., , In: Chitin Enzymology. Ed. R.A.A. Muzzarelli. European Chitin Society, Ancona, 1993
  • Twists and turns in the function of DNA damage signaling and repair proteins by post-translational modifications., , DNA repair, 2007, 10.1016/j.dnarep.2006.12.009
  • Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities., , Oncotarget, 2016, 10.18632/oncotarget.13341
  • [Fanconi anemia animal models - How differences can teach us as much as similarities…]., , Medecine sciences : M/S, 2016, 10.1051/medsci/20163206023
  • PALB2 Variants: Protein Domains and Cancer Susceptibility., , Trends in cancer, 2020, 10.1016/j.trecan.2020.10.002
  • The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms., , American journal of human genetics, 2020, 10.1016/j.ajhg.2020.01.009
  • PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation., , Molecular biology of the cell, 2019, 10.1091/mbc.e18-05-0330
  • Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum., , Nucleic acids research, 2012, 10.1093/nar/gks306
  • DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer., , Biomolecules, 2015, 10.3390/biom5043204
  • MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair., , The EMBO journal, 2009, 10.1038/emboj.2009.193
  • SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing., , Nucleic acids research, 2019, 10.1093/nar/gkz099
  • Functions of the CSB Protein at Topoisomerase 2 Inhibitors-Induced DNA Lesions., , Frontiers in cell and developmental biology, 2021, 10.3389/fcell.2021.727836
  • The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses., , Cell cycle (Georgetown, Tex.), 2009, 10.4161/cc.8.13.8925
  • Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage., , Scientific reports, 2015, 10.1038/srep10475
  • Interplay between human DNA repair proteins at a unique double-strand break in vivo., , The EMBO journal, 2006, 10.1038/sj.emboj.7600914
  • Investigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks., , Scientific reports, 2016, 10.1038/srep23302
  • Methylation of MRE11 regulates its nuclear compartmentalization., , Cell cycle (Georgetown, Tex.), 2005, 10.4161/cc.4.7.1830
  • Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines., , Oncotarget, 2017, 10.18632/oncotarget.10308
  • Multiple regulatory elements control the basal promoter activity of the human alpha 4 integrin gene., , DNA and cell biology, 1994, 10.1089/dna.1994.13.1071
  • Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control., , Genes & development, 2005, 10.1101/gad.1279805
  • A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-nitroquinoline 1-oxide., , The Journal of biological chemistry, 1998, 10.1074/jbc.273.34.21489
  • Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells., , Clinical epigenetics, 2021, 10.1186/s13148-021-01037-1
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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Sadaf Valeh Sheida - Doctorat - En cours
  • Adèle Beneyton - Doctorat - En cours
  • Louis Marie Paul Michel Nonfoux - Doctorat - En cours
  • Sara Berrada - Post-doctorat - En cours
  • Mélissa Thomas - Post-doctorat - En cours
  • Nurgul Atalay - Doctorat - En cours
  • Anuradha Sakhuja - Maîtrise avec mémoire - 2012/01
  • Karine Drapeau - Maîtrise avec mémoire - 2012/05
  • Marie-Michelle Genois - Maîtrise avec mémoire - 2013/05
  • Jana Krietsch - Doctorat - 2014/05
  • Ranjan Maity - Doctorat - 2014/05
  • Joris Pauty - Doctorat - 2015/01
  • Stéphanie Bérubé - Maîtrise avec mémoire - 2015/05
  • Elise Loie - Doctorat - 2016/01
  • Anthony Couturier - Doctorat - 2016/05
  • Niraj Gaurishankar Joshi - Doctorat - 2016/09
  • Emilie Dubois - Doctorat - 2018/01
  • Mandy Ducy - Doctorat - 2019/01
  • Nadine Brahiti - Maîtrise avec mémoire - 2019/09
  • Yuandi Gao - Maîtrise avec mémoire - 2020/09
  • Julia O'Sullivan - Doctorat - 2021/09
  • Thibaut Peterlini - Doctorat - 2022/05
  • Daryl Hyacinth Acuna Ronato - Doctorat - 2023/05

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Médecine moléculaire

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Disponibilité d'encadrement d'étudiant(e)s

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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