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Jorge Soliz

Professeur titulaire

jorge.soliz@criucpq.ulaval.ca
Centre thématique de recherche en neurosciences
Groupe de recherche en santé respiratoire
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec
Centre de recherche de l'IUCPQ
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Neurosciences et santé mentale
Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Santé circulatoire et respiratoire
  • Appareil respiratoire
  • Environnement et maladies respiratoires
Santé différentielle des sexes
  • Stéroïdes
Maladies infectieuses et immunitaires
Subcellulaire

Projets de recherche

  • Hyperactive mitochondria: a novel mechanism to explain early life stress-related sleep apneas in adult mice - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-10-01 au 2027-09-30
  • Collaboration avec l’Institut bolivien de biologie de haute altitude - Affaires mondiales Canada - Programme de mobilité enseignante pour la création de partenariats, chercheur principal - 2024-04-11 au 2025-05-31
  • Estradiol receptor alpha mediates sex-specific responses in an animal model of sleep apnea - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-04-01 au 2024-03-31

Publications

  • Impaired ventilatory acclimatization to hypoxia in female mice overexpressing erythropoietin: unexpected deleterious effect of estradiol in carotid bodies., Soliz J, Johannes Vogel, Doan VD, Pfistner C, Max Gassmann, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2010, 10.1152/ajpregu.00205.2010
  • Pharmacological, but not genetic, alteration of neural Epo modifies the CO2/H+ central chemosensitivity in postnatal mice., Soliz J, nicolas voituron, Laurence BODINEAU, Tam R, Elliot-Portal E, Jeton F, Perrin-Terrin AS, Laouafa S, Jorge Soliz, Respiratory physiology & neurobiology, 2017, 10.1016/j.resp.2017.04.003
  • Diabetes increases the risk of COVID-19 in an altitude dependent manner: An analysis of 1,280,806 Mexican patients., Gonzales GF, Soliz J, Roberto Accinelli, Ruiz-Sánchez C, Mayte Bryce-Alberti, Arianna Portmann, Juan Alonso Leon-Abarca, Jorge Soliz, PloS one, 2021, 10.1371/journal.pone.0255144
  • Brain-derived erythropoietin protects from intermittent hypoxia-induced cardiorespiratory dysfunction and oxidative stress in mice. , Soliz J, Joseph V, Janes TA, Arias-Reyes C, Laouafa S, Elliot-Portal E, Jorge Soliz, Sleep, 2018, 10.1093/sleep/zsy072
  • Efficient breathing at neonatal ages: A sex and Epo-dependent issue., Soliz J, Aida Bairam, Iturri P, Jorge Soliz, Respiratory physiology & neurobiology, 2016, 10.1016/j.resp.2016.12.004
  • Malat1 deficiency prevents hypoxia-induced lung dysfunction by protecting the access to alveoli., Picard F, Bossé Y, Soliz J, Joseph V, Morissette MC, Marsolais D, Jubinville É, Lechasseur A, Aubin S, Beaulieu MJ, Marcouiller F, Arias-Reyes C, Henry C, Miard S, Sallé-Lefort S, Jorge Soliz, Frontiers in physiology, 2022, 10.3389/fphys.2022.949378
  • Dopaminergic metabolism in carotid bodies and high-altitude acclimatization in female rats., Pequignot JM, Spielvogel H, Favier R, Pequignot J, Soria R, Soliz J, Joseph V, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2002, 10.1152/ajpregu.00398.2001
  • Enhanced erythropoietin expression in the brainstem of newborn rats at high altitude., Soliz J, Soria R, Grenacher B, Villalpando G, Gonzales M, Seaborn T, Jorge Soliz, Neuroscience letters, 2011, 10.1016/j.neulet.2011.07.019
  • Erythropoietin and respiratory control at adulthood and during early postnatal life., Soliz J, Jorge Soliz, Respiratory physiology & neurobiology, 2012, 10.1016/j.resp.2012.07.018
  • Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice., Edith Marianne Schneider Gasser, Max Gassmann, Soliz J, Markus Thiersch, Christian Arias Reyes, Laouafa S, Muttathukunnel P, Koester-Hegmann C, Mostafa A. Aboouf, Robert Jacobs, Jorge Soliz, Communications biology, 2021, 10.1038/s42003-021-02465-8
  • Re: "Mortality Attributed to COVID-19 in High-Altitude Populations" by Woolcott and Bergman., Maravi E, Epstein M, Calle-Aracena JM, López-Bascope A, Carmona-Suazo JA, Escalante-Kanashiro R, Arias-Reyes C, Soliz J, Armijo-Subieta NF, Zubieta-DeUrioste N, Alfredo Merino-Luna, Gustavo Zubieta-Calleja, Jorge Soliz, High altitude medicine & biology, 2021, 10.1089/ham.2020.0195
  • Does the pathogenesis of SARS-CoV-2 virus decrease at high-altitude?, , Respiratory physiology & neurobiology, 2020, 10.1016/j.resp.2020.103443
  • Divergent Mitochondrial Antioxidant Activities and Lung Alveolar Architecture in the Lungs of Rats and Mice at High Altitude., Joseph V, Soliz J, Laouafa S, Gonzales M, Valverde I, Villalpando G, Revollo S, Jochmans-Lemoine A, Jorge Soliz, Frontiers in physiology, 2018, 10.3389/fphys.2018.00311
  • Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?, , Respiratory physiology & neurobiology, 2020, 10.1016/j.resp.2020.103476
  • The central chemosensitivity is not altered by cerebral erythropoietin., Soliz J, Joseph V, nicolas voituron, Tam R, Elliot-Portal E, Laouafa S, Ballot O, Jorge Soliz, Neuroscience letters, 2015, 10.1016/j.neulet.2015.10.026
  • Clinical evolution of COVID-19 during pregnancy at different altitudes: a population-based study, Roberto Accinelli, Jorge Soliz, Maria Teresa Peña-Gallardo, Juan Alonso Leon-Abarca, 2020, 10.1101/2020.09.14.20193177
  • Respiratory plasticity in response to changes in oxygen supply and demand., Katherine A. Wilkinson, Tikkanen HO, Rusko HK, Reid SG, Paul RJ, Ken O'Halloran, Miller BM, McGuire M, Maurer J, Kim CB, Max Gassmann, Fu Z, Fergusson EK, Zeis B, Soliz J, Peltonen JE, Hsia CC, Bradford A, Powell FL, Bavis RW, Jorge Soliz, Integrative and comparative biology, 2007, 10.1093/icb/icm070
  • Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis., David Marsolais, Soliz J, Halayko AJ, Janette Burgess, Joseph V, Santos WL, Arias-Reyes C, Laouafa S, Blais-Lecours P, Jorge Soliz, American journal of respiratory cell and molecular biology, 2020, 10.1165/rcmb.2018-0397oc
  • NADH-linked mitochondrial respiration in the developing mouse brain is sex-, age- and tissue-dependent., Soliz J, Furrer D, Gonzales M, Karen Marlene Losantos-Ramos, Arias-Reyes C, Jorge Soliz, Respiratory physiology & neurobiology, 2019, 10.1016/j.resp.2019.05.011
  • Non-erythroid functions of erythropoietin., , Advances in experimental medicine and biology, 2003, 10.1007/978-1-4419-8997-0_22
  • Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice., Max Gassmann, van Patot MT, Borter E, Christophe Soulage, Soliz J, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2008, 10.1152/ajpregu.00876.2007
  • Erythropoietin and its antagonist regulate hypoxic fictive breathing in newborn mice., Soliz J, Christian Gestreau, Seaborn T, Khemiri H, Jorge Soliz, Respiratory physiology & neurobiology, 2012, 10.1016/j.resp.2012.05.027
  • Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats., Vincent Joseph, Aida Bairam, Gozal D, Soliz J, Marcouiller F, Damien Roussel, Laouafa S, Jorge Soliz, Acta physiologica (Oxford, England), 2019, 10.1111/apha.13255
  • Using plethysmography to determine erythropoietin's impact on neural control of ventilation., Soliz J, Max Gassmann, Seaborn T, Jorge Soliz, Methods in molecular biology (Clifton, N.J.), 2013, 10.1007/978-1-62703-308-4_18
  • Role of Estradiol Receptor Beta (ERβ) on Arterial Pressure, Respiratory Chemoreflex and Mitochondrial Function in Young and Aged Female Mice., Joseph V, Aida Bairam, Soliz J, Marcouiller F, Damien Roussel, Laouafa S, Jorge Soliz, Advances in experimental medicine and biology, 2018, 10.1007/978-3-319-91137-3_15
  • PI3K and MEK1/2 molecular pathways are involved in the erythropoietin-mediated regulation of the central respiratory command., Soliz J, Céline Caravagna, Jorge Soliz, Respiratory physiology & neurobiology, 2014, 10.1016/j.resp.2014.11.012
  • Low serum erythropoietin levels are associated with fatal COVID-19 cases at 4,150 meters above sea level., Jorge Soliz, Arias-Reyes C, Zubieta-Calleja G, Zubieta-DeUrioste N, JUAN AMILCAR TINOCO SOLORZANO, Molano-Franco D, Alfredo Merino-Luna, Rada-Barrera G, López-Dávalos MM, Viruez-Soto A, Respiratory physiology & neurobiology, 2021, 10.1016/j.resp.2021.103709
  • Acute and chronic exposure to hypoxia alters ventilatory pattern but not minute ventilation of mice overexpressing erythropoietin., Max Gassmann, Hermann DM, Christophe Soulage, Soliz J, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2007, 10.1152/ajpregu.00350.2007
  • Gestational stress promotes pathological apneas and sex-specific disruption of respiratory control development in newborn rat., Richard Kinkead, Aida Bairam, Soliz J, Céline Caravagna, Gulemetova R, Fournier S, Julien C, Steele S, Fournier S, Jorge Soliz, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/jneurosci.1214-12.2013
  • Gender differentiation of the chemoreflex during growth at high altitude: functional and neurochemical studies., Pequignot JM, Spielvogel H, Favier R, Dalmaz Y, Cottet-Emard JM, Semporé B, Pequignot J, Soliz J, Joseph V, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2000, 10.1152/ajpregu.2000.278.4.r806
  • Hypoxia tolerance in animals: biology and application., Gassmann M, Soliz J, Deten A, Nilsson GE, Morris S, Viney M, Wren JF, Terwilliger N, Welker, A.F., Marcelo Hermes-Lima, Hu J, Wichmann D, Thomas Gorr, Jorge Soliz, Physiological and biochemical zoology : PBZ, 2010, 10.1086/648581
  • The neuronal control of hypoxic ventilation: erythropoietin and sexual dimorphism., Soliz J, Martha C. Tissot van Patot, Max Gassmann, Jorge Soliz, Annals of the New York Academy of Sciences, 2009, 10.1111/j.1749-6632.2009.05028.x
  • Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins., Tanner FC, Lüscher TF, Watanabe T, Steffel J, Pål Johansen, Borén J, Mocharla P, Soliz J, Akhmedov A, Burkhard Becher, Hofmann J, Rohrer L, Susanna Sluka, Rozenberg I, Jorge Soliz, Arteriosclerosis, thrombosis, and vascular biology, 2010, 10.1161/atvbaha.109.201079
  • Cerebral Erythropoietin Prevents Sex-Dependent Disruption of Respiratory Control Induced by Early Life Stress., Soliz J, Kinkead R, Tam R, Laouafa S, Arias-Reyes C, Elliot-Portal E, Jorge Soliz, Frontiers in physiology, 2021, 10.3389/fphys.2021.701344
  • Brain-derived neurotrophic factor interacts with astrocytes and neurons to control respiration., Seaborn T, Soliz J, Céline Caravagna, Jorge Soliz, The European journal of neuroscience, 2013, 10.1111/ejn.12320
  • COVID-19 and Pneumolysis Simulating Extreme High-altitude Exposure with Altered Oxygen Transport Physiology; Multiple Diseases, and Scarce Need of Ventilators: Andean Condor's-eye-view., Soliz J, Kusal Das, Venkatesh T, Zubieta-DeUrioste N, Gustavo Zubieta-Calleja, Jorge Soliz, Reviews on recent clinical trials, 2020, 10.2174/1574887115666200925141108
  • Hypercapnic ventilatory response is decreased in a mouse model of excessive erythrocytosis., Soliz J, Max Gassmann, nicolas voituron, Joseph V, Edith Marianne Schneider Gasser, Revollo S, Elliot-Portal E, Laouafa S, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2016, 10.1152/ajpregu.00226.2016
  • Post-natal hypoxic activity of the central respiratory command is improved in transgenic mice overexpressing Epo in the brain., Soliz J, Richard Kinkead, Céline Caravagna, Jorge Soliz, Respiratory physiology & neurobiology, 2014, 10.1016/j.resp.2014.06.003
  • Soluble erythropoietin receptor is present in the mouse brain and is required for the ventilatory acclimatization to hypoxia., Joseph V, Max Gassmann, Soliz J, Jorge Soliz, The Journal of physiology, 2007, 10.1113/jphysiol.2007.133454
  • Erythropoietin modulates the neural control of hypoxic ventilation., Soliz J, Max Gassmann, Jorge Soliz, Cellular and molecular life sciences : CMLS, 2009, 10.1007/s00018-009-0142-z
  • Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways., Hermann DM, Max Gassmann, Claudio L.A. Bassetti, Soliz J, Kilic U, Kilic E, Jorge Soliz, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, 10.1096/fj.05-3941fje
  • Increased ventilation in female erythropoietin-deficient mouse line is not progesterone and estrous stage-dependent., nicolas voituron, Pichon A, Jean-Paul Richalet, Joseph V, Dominique Marchant, Soliz J, Jeton F, Jorge Soliz, Respiratory physiology & neurobiology, 2017, 10.1016/j.resp.2017.07.002
  • Inhibition of Protein Kinases AKT and ERK1/2 Reduce the Carotid Body Chemoreceptor Response to Hypoxia in Adult Rats., Soliz J, Aida Bairam, Rodrigo G, Joseph V, Iturri P, Jorge Soliz, Advances in experimental medicine and biology, 2015, 10.1007/978-3-319-18440-1_31
  • Long-term effects of neonatal cryoanesthesia on hypoxic ventilatory response in weanling rats depend on neonatal testosterone., Pequignot JM, Soliz J, Joseph V, Jorge Soliz, Advances in experimental medicine and biology, 2003, 10.1007/978-1-4419-9280-2_70
  • Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin., Max Gassmann, Lundby C, Christophe Soulage, Thomsen JJ, Soliz J, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2009, 10.1152/ajpregu.90967.2008
  • Neonatal Maternal Separation Augments Carotid Body Response to Hypoxia in Adult Males but Not Female Rats., Richard Kinkead, Tam R, Soliz J, Jorge Soliz, Frontiers in physiology, 2016, 10.3389/fphys.2016.00432
  • HIF1α and physiological responses to hypoxia are correlated in mice but not in rats., Vincent Joseph, Soliz J, Shahare M, Jochmans-Lemoine A, Jorge Soliz, The Journal of experimental biology, 2016, 10.1242/jeb.142869
  • Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies., Max Gassmann, Omolara Ogunshola, Pequignot JM, Johannes Vogel, Becskei C, Christophe Soulage, Joseph V, Soliz J, Jorge Soliz, The Journal of physiology, 2005, 10.1113/jphysiol.2005.093328
  • Chronic overexpression of cerebral Epo improves the ventilatory response to acute hypoxia during the postnatal development., Soliz J, Joseph V, Ballot O, Edith Marianne Schneider Gasser, Céline Caravagna, Jorge Soliz, International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2015, 10.1016/j.ijdevneu.2015.06.001
  • Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill COVID-19 patients at high altitudes., Soliz J, Arias-Reyes C, Zubieta-Calleja G, Zubieta-DeUrioste N, Danuzia Ambrozio Marques, JUAN AMILCAR TINOCO SOLORZANO, Molano-Franco D, Alfredo Merino-Luna, Rada-Barrera G, Casas-Mamani R, Arias S, Viruez-Soto A, Jorge Soliz, Respiratory physiology & neurobiology, 2022, 10.1016/j.resp.2022.103868
  • Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2., Hermann DM, Max Gassmann, Claudio L.A. Bassetti, Soliz J, Kilic E, Kilic U, Jorge Soliz, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, 10.1096/fj.04-2493fje
  • Decreased incidence, virus transmission capacity, and severity of COVID-19 at altitude on the American continent., Jorge Soliz, Mathias Dutschmann, Gustavo Zubieta-Calleja, Edith Marianne Schneider Gasser, Accinelli RA, Natalia Zubieta-DeUrioste, Danuzia Ambrozio Marques, Aliaga-Raduán F, Poma-Machicao L, Carvajal-Rodriguez F, Christian Arias Reyes, PloS one, 2021, 10.1371/journal.pone.0237294
  • Corrigendum: Testosterone Supplementation Induces Age-Dependent Augmentation of the Hypoxic Ventilatory Response in Male Rats With Contributions From the Carotid Bodies., Kinkead R, Soliz J, Joseph V, Fournier S, Ambrozio-Marques D, Janes TA, Jorge Soliz, Frontiers in physiology, 2022, 10.3389/fphys.2022.964673
  • PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons., Bayliss DA, Wagner CA, Guyenet PG, Seuwen K, Suply T, Max Gassmann, Bettoni C, Mohebbi N, Perez-Reyes E, Ludwig MG, Lazarenko RM, Stephen BG Abbott, Sen J, Janelle Weaver, Sheng Wang, Li K, Shi Y, Velic A, Soliz J, Natasha Kumar, Jorge Soliz, Science (New York, N.Y.), 2015, 10.1126/science.aaa0922
  • Erythropoietin and the sex-dimorphic chemoreflex pathway., , Advances in experimental medicine and biology, 2012, 10.1007/978-94-007-4584-1_8
  • Mice and Rats Display Different Ventilatory, Hematological, and Metabolic Features of Acclimatization to Hypoxia., Joseph V, Soliz J, Arias-Reyes C, Jorge Soliz, Frontiers in physiology, 2021, 10.3389/fphys.2021.647822
  • Testosterone Supplementation Induces Age-Dependent Augmentation of the Hypoxic Ventilatory Response in Male Rats With Contributions From the Carotid Bodies., Kinkead R, Soliz J, Joseph V, Fournier S, Ambrozio-Marques D, Janes TA, Jorge Soliz, Frontiers in physiology, 2021, 10.3389/fphys.2021.781662
  • Erythropoietin and caffeine exert similar protective impact against neonatal intermittent hypoxia: Apnea of prematurity and sex dimorphism., Soliz J, Aida Bairam, Joseph V, Gonzales M, Marcouiller F, Arias-Reyes C, Iturri P, Laouafa S, Jorge Soliz, Experimental neurology, 2019, 10.1016/j.expneurol.2019.112985
  • Developmental expression patterns of erythropoietin and its receptor in mouse brainstem respiratory regions., Soliz J, Khalid K, Omolara Ogunshola, Karen Marlene Losantos-Ramos, Arias-Reyes C, Elliot-Portal E, Edith Marianne Schneider Gasser, Jorge Soliz, Respiratory physiology & neurobiology, 2019, 10.1016/j.resp.2019.05.012
  • Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats., Luciane Gargaglioni, Soliz J, Tenorio-Lopes L, Vicente MC, Silva CA, Jorge Soliz, Respiratory physiology & neurobiology, 2016, 10.1016/j.resp.2016.10.011
  • Perinatal steroid exposure and respiratory control during early postnatal life., Joseph V, Soliz J, Jorge Soliz, Respiratory physiology & neurobiology, 2005, 10.1016/j.resp.2005.01.013
  • Endogenous brain erythropoietin is a potent sex-specific respiratory stimulant in adult and newborn mice., Soliz J, Joseph V, Ballot O, Jorge Soliz, Journal of applied physiology (Bethesda, Md. : 1985), 2015, 10.1152/japplphysiol.00143.2015

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Jaime Pablo Iturri Soliz - Doctorat - En cours
  • Fernanda Aliaga Raduan - Doctorat - En cours
  • Andres Bruno Rojas Ruiz - Doctorat - En cours
  • Céline Michelle Caravagna - Doctorat - 2015/01
  • Hanan Khemiri - Doctorat - 2015/05
  • Orlane Ballot - Maîtrise avec mémoire - 2016/01
  • Manju Shahare - Maîtrise avec mémoire - 2016/01
  • Charlotte Lemieux-Bourque - Maîtrise avec mémoire - 2021/05
  • Christian Luis Carlos Arias Reyes - Doctorat - 2023/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Neurobiologie — Neurosciences

En savoir plus sur les programmes

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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