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Laetitia Michou

Médecin clinicienne enseignante agrégée

Laetitia Michou
laetitia.michou@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Pédagogie des sciences de la santé
Perte d’autonomie et réadaptation
Reproduction, génétique, périnatalité et développement
Transfert des connaissances

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
  • Tissu osseux
  • Ostéoporose
  • Maladies du tissu osseux
  • Déformation musculosquelettique
Génétique humaine
  • Maladies génétiques
  • Marqueurs génétiques
  • Génomique
  • Phénotype
  • Gènes de susceptibilité
  • Mutation (processus)
  • Polymorphisme
  • Interactions gènes et environnement

Projets de recherche

  • Multifaceted Intervention using Telehealth to Reduce the risk of Falls and Fractures in Older Men (MisterFit study): a Pilot Study - Instituts de recherche en santé du Canada, University of Waterloo, co-chercheur - 2021-10-01 au 2025-09-30
  • Étude des évènements cardiovasculaires et des calcifications vasculaires dans la maladie osseuse de Paget - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, chercheur principal - 2024-01-31 au 2025-02-28
  • Transgenic rats overexpressing HDAC9 to explore the missing link between osteoporosis and vascular disease in chronic kidney disease - CHU de Québec – Université Laval – CHUL - Aide à la recherche, co-chercheur - 2023-06-21 au 2024-03-31
  • Rôle de SUPT20H dans la pathogénie de la polyarthrite rhumatoïde - Société Française de Rhumatologie (France), chercheur principal - 2022-03-10 au 2023-02-28
  • Financement pour projet de recherche clinique en rhumatologie, mai 2020 - Fondation du CHU de Québec, chercheur principal - 2020-05-14 au 2021-03-31
  • Clinical validity and clinical utility of a screening test for Paget's disease of bone - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-03-01 au 2020-03-31

Publications

  • Assessment of femur geometrical parameters using EOS™ imaging technology in patients with atypical femur fractures; preliminary results, Brown, J.P., Rahme, E., de Guise, J.A., Ste-Marie, L.-G., Michou, L., Moser, T.P., Godbout, B., Belzile, E.L., Wall, M., Morin, S.N., Bone, 2016, 10.1016/j.bone.2015.10.016
  • The changing countenance of Paget's Disease of bone, Orcel, P., Michou, L., Joint Bone Spine, 2016, 10.1016/j.jbspin.2016.02.011
  • Rapid efficacy of highly active antiretroviral therapy in a case of HIV myelitis, Sereni, D., Maillard, A., Lamotte, C., Sereni, C., Sauve, C., Michou, L., European Journal of Internal Medicine, 2002, 10.1016/S0953-6205(01)00193-5
  • Environmental factors associated with familial or non-familial forms of Paget's disease of bone,Facteurs environnementaux associés aux formes familiales et non familiales de maladie osseuse de Paget, Michou, L., Brown, J.P., Dumont, J., Guay-Bélanger, S., Beaudoin, C., Jean, S., Audet, M.-C., Revue du Rhumatisme (Edition Francaise), 2018, 10.1016/j.rhum.2017.09.006
  • Granulomatous synovitis after intraarticular Hylan GF-20. A report of two cases, Kahan, A., De Pinieux, G., Job-Deslandre, C., Michou, L., Joint Bone Spine, 2004, 10.1016/j.jbspin.2003.09.006
  • A novel nonsense variant in SUPT20H gene associated with Rheumatoid Arthritis identified by Whole Exome Sequencing of multiplex families, Valérie Chaudru, Elisabeth Petit-Teixeira, François Cornelis, Jean-François Deleuze, Robert Olaso, Robert Olaso, Christophe Caloustian, Anne Boland, Laetitia Michou, Javier Perea, Maëva Veyssiere, 2018, 10.1101/430223
  • Association study of VDR gene with rheumatoid arthritis in the French population, Ayadi, H., Cornelis, F., Rebai, A., Michou, L., Petit-Teixeira, E., Maalej, A., Genes and Immunity, 2005, 10.1038/sj.gene.6364260
  • Environmental factors associated with familial or non-familial forms of Paget's disease of bone, Michou, L., Brown, J.P., Dumont, J., Guay-Bélanger, S., Beaudoin, C., Jean, S., Audet, M.-C., Joint Bone Spine, 2017, 10.1016/j.jbspin.2016.11.010
  • Has Paget's disease become a rare bone disease?,La maladie de Paget est-elle devenue une maladie osseuse rare ?, Orcel, P., Michou, L., Revue du Rhumatisme Monographies, 2019, 10.1016/j.monrhu.2018.11.008
  • What are the rheumatology educational preferences of family medicine residents? A descriptive study, Michou, L., Bessette, L., Rheault, C., Julien, A.-S., Lagacé, S., Clinical Rheumatology, 2020, 10.1007/s10067-020-05018-2
  • Prevalence and Characteristics of Atypical Periprosthetic Femoral Fractures, Belzile, E.L., Simonyan, D., Pelet, S., Vaillancourt, F., Michou, L., Leclerc, J.-T., Journal of Bone and Mineral Research, 2019, 10.1002/jbmr.3584
  • Genetics of bone diseases: Paget's disease, fibrous dysplasia, osteopetrosis, and osteogenesis imperfecta, Brown, J.P., Michou, L., Joint Bone Spine, 2011, 10.1016/j.jbspin.2010.07.010
  • Bilateral distal fibula fractures in a woman on long-term bisphosphonate therapy, Michou, L., Bédard, M., Audet, M.C., Murray, J.C., Osteoporosis International, 2016, 10.1007/s00198-015-3396-3
  • Epidemiogenetic study of French families with Paget's disease of bone,Étude épidémiogénétique de familles françaises avec maladie osseuse de Paget, Orcel, P., Brown, J.P., Laplanche, J.-L., Launay, J.-M., Gagnon, E., Thomas, T., Audran, M., Morissette, J., Collet, C., Michou, L., Revue du Rhumatisme (Edition Francaise), 2012, 10.1016/j.rhum.2011.07.007
  • High bone mass in adults, Guggenbuhl, P., Cortet, B., Debiais, F., Kolta, S., Michou, L., Paccou, J., Joint Bone Spine, 2018, 10.1016/j.jbspin.2018.01.007
  • Measuring the impact of an educational intervention in rheumatoid arthritis: An open-label, randomized trial, Paul R Fortin, Anne-Laure Chetaille, Louis Bessette, Isabelle Fortin, Jean-Luc Tremblay, Judith Trudeau, Alena Ikic, Rebecca Lui, Geneviève Boily, Suzanne Côté, Johanne Tardif, Alexandra Godbout, Lucie Ratelle, Jean Légaré, Holly O. Witteman, Anne-Sophie Julien, Laëtitia Michou, Archives of Rheumatology, 2022, 10.46497/ArchRheumatol.2022.8965
  • When to refer to genetic consultation?,Quand demander un avis génétique ?, Michou, L., Revue du Rhumatisme Monographies, 2010, 10.1016/j.monrhu.2010.06.003
  • Novel SQSTM1 mutations in patients with Paget's disease of bone in an unrelated multiethnic American population, Siris, E.S., Brown, J.P., Dellabadia, M., Marquis, A., Gagnon, E.R., Morissette, J., Michou, L., Bone, 2011, 10.1016/j.bone.2010.11.004
  • Change in fracture risk and fracture pattern after bariatric surgery: Nested case-control study, Gagnon, C., Michou, L., Biertho, L., Mac-Way, F., Lebel, S., Gamache, P., Jean, S., Rousseau, C., BMJ (Online), 2016, 10.1136/bmj.i3794
  • Detection of SQSTM1/P392L post-zygotic mutations in Paget’s disease of bone, , 1911
  • Paget's bone disease, an evanescent condition?,La maladie osseuse de Paget, une condition évanescente ?, Michou, L., Cormier, J.-G., Guay-Bélanger, S., Revue du Rhumatisme (Edition Francaise), 2015, 10.1016/j.rhum.2014.10.006
  • Genetics of low back pain,Génétique des lombalgies, Michou, L., Revue du Rhumatisme Monographies, 2014, 10.1016/j.monrhu.2013.07.001
  • IRF5 rs2004640-T allele, the new genetic factor for systemic lupus erythematosus, is not associated with rheumatoid arthritis, Cornélis, F., Prum, B., Bardin, T., Lasbleiz, S., Tan, A., Barbet, S., Michou, L., Dieudé, P., Garnier, S., Annals of the Rheumatic Diseases, 2007, 10.1136/ard.2006.061390
  • Septic arthritis of the hip with psoas abscess caused by Non-typhi Salmonella infection in an immunocompetent patient, Richette, P., Hannouche, D., Orcel, P., Michou, L., Compain, C., Joint Bone Spine, 2008, 10.1016/j.jbspin.2007.01.042
  • Genetic study: Association of the CLEC12A gene with rheumatoid arthritis,Étude génétique: association du gène CLEC12A avec la polyarthrite rhumatoïde, Fernandes, M.J.G., Petit-Teixeira, É., Bardin, T., Migliorini, P., Van De Putte, L., Alves, H., Barrera, P., Westhovens, R., Balsa, A., Bombardieri, S., Levesque, J.-M., Cornélis, F., Michou, L., Revue du Rhumatisme (Edition Francaise), 2012, 10.1016/j.rhum.2012.02.009
  • Paget's Disease of Bone: Prognosis and Complications, Brown, J.P., Michou, L., Advances in Pathobiology and Management of Paget's Disease of Bone, 2016, 10.1016/B978-0-12-805083-5.00008-7
  • Paget's disease of bone: A disease with declining prevalence?,La maladie osseuse de Paget : une maladie en voie de disparition ?, Orcel, P., Michou, L., Revue du Rhumatisme (Edition Francaise), 2015, 10.1016/S1169-8330(16)30067-9
  • Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62P392L mutation to paget's disease, Roodman, G.D., Brown, J.P., Windle, J.J., Dempster, D.W., Zhou, H., Teramachi, J., Galson, D.L., Morissette, J., Rousseau, C., Michou, L., Yamana, K., Hiruma, Y., Kurihara, N., Cell Metabolism, 2011, 10.1016/j.cmet.2010.12.002
  • Septic arthritis of the hip with psoas abscess caused by non-typhi salmonella infection in an immunocompetent patient,Arthrite septique de hanche avec abcès du psoas due à une salmonelle non typhique chez un sujet immunocompétent, Richette, P., Hannouche, D., Orcel, P., Michou, L., Compain, C., Revue du Rhumatisme (Edition Francaise), 2008, 10.1016/j.rhum.2007.02.032
  • Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone, Cancela, M.L., Brown, J.P., Siris, E.S., Miltenberger-Miltenyi, G., Gagnon, E., Morissette, J., Conceição, N., Michou, L., Bone, 2012, 10.1016/j.bone.2012.06.028
  • Genetics of Paget's disease of bone, Cornélis, F., Orcel, P., Laplanche, J.-L., Collet, C., Michou, L., Joint Bone Spine, 2006, 10.1016/j.jbspin.2005.05.009
  • Genetics of digital osteoarthritis,Génétique de l'arthrose digitale, Michou, L., Revue du Rhumatisme (Edition Francaise), 2011, 10.1016/j.rhum.2010.08.002
  • Effect of a rare genetic variant of TM7SF4 gene on osteoclasts of patients with Paget’s disease of bone, Laëtitia Michou, Jacques P. Brown, Edith Gagnon, Nathalie Amiable, Emilie Laurier, BMC Medical Genetics, 2017, 10.1186/s12881-017-0495-3
  • Granulomatous synovitis after intra-articular Hylan GF-20. A report of two cases,Synovite granulomateuse après injection de hylane GF-20. À propos de deux cas, Kahan, A., de Pinieux, G., Job-Deslandre, C., Michou, L., Revue du Rhumatisme (Edition Francaise), 2004, 10.1016/j.rhum.2003.09.013
  • Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W allele., Cornélis, F., Prum, B., Bardin, T., Lasbleiz, S., Pierlot, C., Glikmans, E., Petit-Teixeira, E., Michou, L., Garnier, S., Dieudé, P., Arthritis research & therapy, 2005
  • Erratum to Gene expression profile in osteoclasts from patients with Paget's disease of bone [Bone 46, (2010), 598-603], Roux, S., Brown, J.P., Morissette, J., Couture, J., Chamoux, E., Michou, L., Bone, 2010, 10.1016/j.bone.2010.02.023
  • Replication of the tumor necrosis factor receptor-associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a european family-based study, Toes, R.E.M., Petit-Teixeira, E., Huizinga, T.W.J., Cornelis, F., Gut, I., Bardin, T., Prum, B., Lopes-Vaz, A., Van De Putte, L., Van Riel, P., Radstake, T., Bombardieri, S., Michou, L., Pascual-Salcedo, D., Fernandes, M., Vaz, C., Alves, H., Barrera, P., Westhovens, R., Balsa, A., Migliorini, P., Teixeira, V.H., Vrijmoet, S., Houwing-Duistermaat, J., Rocha, D., Kurreeman, F.A.S., Arthritis and Rheumatism, 2008, 10.1002/art.23793
  • Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis, Fernandes, M.J., Fortin, P.R., Michou, L., Bessette, L., Tessier, P.A., Pelletier, M., Amiable, N., Julien, A.-S., Kerever, A., Lachhab, A., Pagé, N., Paré, G., Desaulniers, P., Vaillancourt, M., Scientific Reports, 2021, 10.1038/s41598-021-90631-7
  • Genetics of Dupuytren's disease, Petit-Teixeira, E., Beaudreuil, J., Bardin, T., Teyssedou, J.-P., Lermusiaux, J.-L., Michou, L., Joint Bone Spine, 2012, 10.1016/j.jbspin.2011.05.027
  • Epidemiogenetic study of French families with Paget’s disease of bone, , 1911
  • Clinical peripheral enthesitis in the DESIR prospective longitudinal axial spondyloarthritis cohort, Dougados, M., Haraoui, P., Wendling, D., Claudepierre, P., D'Agostino, M.-A., Michou, L., Bessette, L., Etcheto, A., Moltó, A., Nadon, V., Clinical and experimental rheumatology, 2019
  • Identification of rare genetic variants in novel loci associated with Paget's disease of bone, Michou, L., Brown, J.P., Morissette, J., Guay-Bélanger, S., Gagnon, E., Beauregard, M., Human Genetics, 2014, 10.1007/s00439-013-1409-x
  • Genetics of bone diseases,Génétique des maladies osseuses, Brown, J.P., Michou, L., Revue du Rhumatisme Monographies, 2010, 10.1016/j.monrhu.2010.04.022
  • Gene-environment interactions in Paget's disease of bone, Michou, L., Brown, J.P., Amiable, N., Gagnon, E., Dessay, M., Jean, S., Numan, M.S., Joint Bone Spine, 2019, 10.1016/j.jbspin.2018.12.007
  • Clinical phenotype of adult offspring carriers of the p.Pro392Leu mutation within the SQSTM1 gene in Paget's disease of bone, Michou, L., Brown, J.P., Albert, C., Gagnon, E., Gleeton, G., Samson, A., Simonyan, D., Jobin Gervais, F., Dessay, M., Bone Reports, 2020, 10.1016/j.bonr.2020.100717
  • Sharing ongoing care with primary care physicians opens up opportunity for timelier and earlier care by rheumatologists for patients with new inflammatory polyarthritis, Michou, L., Fortin, P.R., Bessette, L., Julien, A.-S., Nguyen, P., Journal of Rheumatology, 2018, 10.3899/jrheum.170494
  • Has Paget's bone disease become rare?, Orcel, P., Michou, L., Joint Bone Spine, 2019, 10.1016/j.jbspin.2019.01.015
  • The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: A family-based study, Cornélis, F., Bardin, T., Prum, B., Mbarek, H., Petit-Teixeira, E., Teixeira, V.H., Hilliquin, P., Quillet, P., Lemaire, I., Lasbleiz, S., Barbet, S., Glikmans, E., Lopes-Vaz, A., van de Putte, L., Van Riel, P., Radstake, T.R., Dequeker, J., Bombardieri, S., Pascual-Salcedo, D., Fernandes, M., Vaz, C., Alves, H., Barrera, P., Westhovens, R., Balsa, A., Migliorini, P., Pierlot, C., Michou, L., Dieudé, P., Garnier, S., Jacq, L., Arthritis Research and Therapy, 2007, 10.1186/ar2221
  • Molecular analysis of Paget's disease of bone,Analyse moléculaire de la maladie osseuse de Paget, Orcel, P., Collet, C., Michou, L., Pathologie Biologie, 2007, 10.1016/j.patbio.2006.06.005
  • Expectations and educational needs of rheumatologists, rheumatology fellows and patients in the field of precision medicine in Canada, a quantitative cross-sectional and descriptive study, Laëtitia Michou, Maman Joyce Dogba, Diane Lacaille, Paul R. Fortin, Louis Bessette, Jean Légaré, David Simonyan, Sophie Ruel-Gagné, BMC Rheumatology, 2021, 10.1186/s41927-021-00222-2
  • Incidence and Characteristics of Atypical Femoral Fractures: Clinical and Geometrical Data, Michou, L., Belzile, É.L., Dumont, J., Grondin, C., Pelet, S., Boulet, D., Brown, J.P., Leclerc, J.-T., Jean, S., Mahjoub, Z., Journal of Bone and Mineral Research, 2016, 10.1002/jbmr.2748
  • Mutations of the cystic fibrosis gene in patients with bronchiectasis associated with rheumatoid arthritis, Dusser, D.J., Kahan, A., Cornélis, F., Michou, L., Lasbleiz, S., Marcelli, C., Gaudin, P., Sibilia, J., Berthelot, J.-M., Génin, E., Bienvenu, T., Puéchal, X., Annals of the Rheumatic Diseases, 2011, 10.1136/ard.2010.142760
  • Genetic association study of dickkopf-1 and sclerostin genes with paget disease of bone, Michou, L., Brown, J.P., Morissette, J., Siris, E.S., Guay-Bélanger, S., Gagnon, E., Beauregard, M., Calcified Tissue International, 2013, 10.1007/s00223-013-9762-2
  • Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene, Stravopoulos, C., Spyropoulou, M., Weissenbach, J., Prud'homme, J.-F., Martinez, M., Kuntz, D., Fauré, S., Charron, D., Cornélis, F., Dieudé, P., Bardin, T., Prum, B., Lopes-Vaz, A., Van De Putte, L., Van Riel, P., Radstake, T.R., Dequeker, J., Bombardieri, S., Pascual-Salcedo, D., Lemaire, I., Petit-Teixeira, E., Fernandes, M., Vaz, C., Dausset, J., Garnier, S., Glikmans, E., Pierlot, C., Alves, H., Barrera, P., Westhovens, R., Balsa, A., Migliorini, P., Rat, A.-C., Lasbleiz, S., Michou, L., Proceedings of the National Academy of Sciences of the United States of America, 2007, 10.1073/pnas.0610250104
  • Breast cancer and microcalcifications: An osteoimmunological disorder?, Durocher, F., Diorio, C., Michou, L., Clemenceau, A., International Journal of Molecular Sciences, 2020, 10.3390/ijms21228613
  • Assessment of the educational impact of an information leaflet on the knowledge of complications in systemic sclerosis,Évaluation de l'impact d'une brochure d'information sur la connaissance des complications dans la sclérodermie systémique, Michou, L., Fortin, P.R., Bessette, L., Brown, J.P., Beaudoin, C., Ikic, A., Revue du Rhumatisme (Edition Francaise), 2015, 10.1016/j.rhum.2015.04.001
  • ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor, Gianfrancesco, F., Gennari, L., Rendina, D., Michou, L., Benassi, M.S., Cancela, M.L., Strazzullo, P., Nuti, R., Brown, J.P., Orcel, P., Siris, E., Del Fattore, A., Pazzaglia, L., Merlotti, D., Esposito, T., Formicola, D., Divisato, G., American Journal of Human Genetics, 2016, 10.1016/j.ajhg.2015.12.016
  • New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility, Clerget-Darpoux, F., Cornelis, F., Prum, B., Bardin, T., Quillet, P., Pierlot, C., Lasbleiz, S., Lemaire, I., Osorio, J., Petit-Teixeira, E., Michou, L., Tezenas Du Montcel, S., Arthritis and Rheumatism, 2005, 10.1002/art.20989
  • A novel nonsense variant in SUPT20H gene associated with Rheumatoid Arthritis identified by Whole Exome Sequencing of multiplex families, Valérie Chaudru, Elisabeth Petit-Teixeira, François Cornelis, Jean-François Deleuze, Robert Olaso, Christophe Caloustian, Anne Boland, Laetitia Michou, Javier Perea, Maëva Veyssiere, PLOS ONE, 2019, 10.1371/journal.pone.0213387
  • HLA shared epitope and ACPA: Just a marker or an active player?, Migliorini, P., Cornelis, F., Sette, A., Puxeddu, I., Michou, L., Sidney, J., Petit Teixeira, E., Pratesi, F., Autoimmunity Reviews, 2013, 10.1016/j.autrev.2013.08.002
  • Identification of rare genetic variants in five novel loci associated with Paget’s disease of bone, , 1911
  • HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population, Cornélis, F., Petit-Teixeira, E., Mbarek, H., Hilliquin, P., Quillet, P., Lemaire, I., Pierlot, C., Rocha, D., Dieudé, P., Michou, L., Garnier, S., Teixeira, V.H., Jacq, L., Journal of Human Genetics, 2007, 10.1007/s10038-007-0201-y
  • Genetics of Paget's disease of bone {lozenge, open}{lozenge, open}Pour citer cet article, utiliser ce titre en anglais et sa référence dans le même volume de Joint Bone Spine.,Génétique de la maladie de Paget, Cornélis, F., Orcel, P., Laplanche, J.-L., Collet, C., Michou, L., Revue du Rhumatisme (Edition Francaise), 2006, 10.1016/j.rhum.2005.05.015
  • Paget’s disease of bone: An osteoimmunological disorder?, Michou, L., Brown, J.P., Amiable, N., Numan, M.S., Drug Design, Development and Therapy, 2015, 10.2147/DDDT.S88845
  • Measles virus nucleocapsid protein increases osteoblast differentiation in Paget's disease, Roodman, G.D., Kurihara, N., Windle, J.J., Brown, J.P., Michou, L., Guise, T., Ohata, Y., Inagaki, Y., Mohammad, K., Nagata, Y., Teramachi, J., Journal of Clinical Investigation, 2016, 10.1172/JCI82012
  • Effects of Biliopancreatic Diversion on Bone Turnover Markers and Association with Hormonal Factors in Patients with Severe Obesity, Gagnon, C., Marceau, S., Lebel, S., Biertho, L., Tchernof, A., Michou, L., Mac-Way, F., Carpentier, A.C., Carreau, A.-M., Simonyan, D., Ung, R.-V., Grenier-Larouche, T., Turcotte, A.-F., Obesity Surgery, 2019, 10.1007/s11695-018-3617-x
  • Lack of linkage and association of adrenomedulin and its receptor genes in French Caucasian rheumatoid arthritis trio families, Lioté, F., Cornélis, F., Bardin, T., Lasbleiz, S., Ah Kioon, M.-D., Asensio, C., Uzan, B., Ea, H.-K., Glikmans, E., Barbet, S., Garnier, S., Michou, L., Clinical and Experimental Rheumatology, 2008
  • Emerging strategies and therapies for treatment of paget's disease of bone, Brown, J.P., Michou, L., Drug Design, Development and Therapy, 2011, 10.2147/DDDT.S11306
  • Paget's disease of bone in the French population: Novel SQSTM1 mutations, functional analysis, and genotype-phenotype correlations, Laplanche, J.-L., Orcel, P., Launay, J.-M., Cornélis, F., Lemaire, I., Bardin, T., Hilliquin, P., Chasseigneaux, S., Audran, M., Michou, L., Collet, C., Journal of Bone and Mineral Research, 2007, 10.1359/jbmr.061106
  • High bone mass in adults,Les hyperdensités osseuses de l'adulte, Guggenbuhl, P., Cortet, B., Debiais, F., Kolta, S., Michou, L., Paccou, J., Revue du Rhumatisme (Edition Francaise), 2018, 10.1016/j.rhum.2017.11.010
  • Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis, Cornélis, F., Clerget-Darpoux, F., Prum, B., Bardin, T., Quillet, P., Lasbleiz, S., Frigui, W., Osorio, J., Pierlot, C., Lemaire, I., du Montcel, S.T., Petit-Teixeira, E., Croiseau, P., Michou, L., Arthritis Research and Therapy, 2006, 10.1186/ar1949
  • Epigenetics of bone diseases, Michou, L., Joint Bone Spine, 2018, 10.1016/j.jbspin.2017.12.003
  • Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease, Kurihara, N., Roodman, G.D., Windle, J.J., Dempster, D.W., Zhou, H., Subler, M.A., Galson, D.L., Cao, H., Michou, L., Brown, J.P., Ishizuka, H., Ishizuka, S., Hiruma, Y., Teramachi, J., Journal of Bone and Mineral Research, 2013, 10.1002/jbmr.1884
  • Associations between genetic factors, tobacco smoking and autoantibodies in familial and sporadic rheumatoid arthritis, Petit-Teixeira, E., Cornélis, F., Prum, B., Dieudé, P., Bardin, T., Lasbleiz, S., Pierlot, C., Teixeira, V.H., Michou, L., Annals of the Rheumatic Diseases, 2008, 10.1136/ard.2007.075622
  • Genetics of Dupuytren's disease,Génétique de la maladie de Dupuytren, Petit-Teixeira, E., Beaudreuil, J., Bardin, T., Teyssedou, J.-P., Lermusiaux, J.-L., Michou, L., Revue du Rhumatisme (Edition Francaise), 2011, 10.1016/j.rhum.2011.03.013
  • Paget's disease of bone, Orcel, P., Cornélis, F., Michou, L., Rousière, M., Best Practice and Research: Clinical Rheumatology, 2003, 10.1016/j.berh.2003.09.003
  • Can zebrafish be a valid model to study Paget's disease of bone?, Cancela, M.L., Michou, L., Conceição, N., Silva, I.A.L., Journal of Applied Ichthyology, 2014, 10.1111/jai.12523
  • Prevalence of Vertebral Fractures in Adults With Type 1 Diabetes: DenSiFy Study (Diabetes Spine Fractures), Claudia Gagnon, Rémi Rabasa-Lhoret, Suzanne N Morin, Caroline Albert, Fabrice Mac-Way, S John Weisnagel, Laëtitia Michou, Mathieu Genest, William D Leslie, Élodie Garceau, Julie-Catherine Coll, The Journal of Clinical Endocrinology & Metabolism, 2022, 10.1210/clinem/dgac031
  • Dense genome-wide linkage analysis of rheumatoid arthritis, including covariates, Cornélis, F., Olson, J.M., Prum, B., Bardin, T., Quillet, P., Alibert, O., Lasbleiz, S., Lemaire, I., Cailleau-Moindrault, S., Pierlot, C., Michou, L., Petit-Teixeira, E., Bukulmez, H., Osorio Y Fortéa, J., Arthritis and Rheumatism, 2004, 10.1002/art.20458
  • Prevalence and distribution of autoimmune diseases in 368 rheumatoid arthritis families, Cornélis, F., Bardin, T., Lasbleiz, S., Rat, A.-C., Michou, L., Journal of Rheumatology, 2008
  • Molecular effect of an OPTN common variant associated to Paget's disease of bone, Laëtitia Michou, M. Leonor Cancela, Jacques P. Brown, Édith Gagnon, Natércia Conceição, Iris A. L. Silva, PLOS ONE, 2018, 10.1371/journal.pone.0197543
  • A genetic association study of the CLEC12A gene in rheumatoid arthritis, Fernandes, M.J.G., Petit-Teixeira, E., Bardin, T., Migliorini, P., van de Putte, L., Alves, H., Barrera, P., Westhovens, R., Balsa, A., Bombardieri, S., Levesque, J.-M., Cornélis, F., Michou, L., Joint Bone Spine, 2012, 10.1016/j.jbspin.2011.12.012
  • Epidemiogenetic study of French families with Paget's disease of bone, Orcel, P., Brown, J.P., Laplanche, J.-L., Launay, J.-M., Gagnon, E., Thomas, T., Audran, M., Morissette, J., Collet, C., Michou, L., Joint Bone Spine, 2012, 10.1016/j.jbspin.2011.07.005
  • Impact of air pollutants on oxidative stress in common autophagy-mediated aging diseases, Michou, L., Brown, J.P., Numan, M.S., International Journal of Environmental Research and Public Health, 2015, 10.3390/ijerph120202289
  • Gene expression profile in osteoclasts from patients with Paget's disease of bone, Roux, S., Brown, J.P., Morissette, J., Couture, J., Chamoux, E., Michou, L., Bone, 2010, 10.1016/j.bone.2009.11.012
  • Genetic association of Dickkopf 1 and Sclerostin genes with Paget’s disease of bone, , 1911
  • Epigenetics of bone diseases,Épigénétique des maladies osseuses, Michou, L., Revue du Rhumatisme (Edition Francaise), 2018, 10.1016/j.rhum.2017.11.008
  • Genetics of digital osteoarthritis, Michou, L., Joint Bone Spine, 2011, 10.1016/j.jbspin.2010.09.012
  • Association study of the platelet collagen receptor glycoprotein VI gene with rheumatoid arthritis, Boilard, E., Petit-Teixeira, E., Bardin, T., Migliorini, P., Radstake, T.R.D.J., Alves, H., Barrera, P., Westhovens, R., Balsa, A., Bombardieri, S., Baron, M., Cornélis, F., Michou, L., Clinical and Experimental Rheumatology, 2013
  • Alternative splicing in osteoclasts and Paget's disease of bone, Roux, S., Brown, J.P., Michou, L., McManus, S., Bisson, M., Laberge, G., Klinck, R., BMC Medical Genetics, 2014, 10.1186/s12881-014-0098-1
  • Detection of SQSTM1/P392L post-zygotic mutations in Paget’s disease of bone, Michou, L., Brown, J.P., Orcel, P., Siris, E.S., Morissette, J., Gagnon, E., Picard, S., Guay-Bélanger, S., Human Genetics, 2015, 10.1007/s00439-014-1488-3
  • Association study of the RANK locus in white European rheumatoid arthritis families, Petit-Teixeira, E., Cornélis, F., Bardin, T., Lopes-Vaz, A., Van De Putte, L., Van Riel, P., Radstake, T.R., Dequeker, J., Bombardieri, S., Pascual-Salcedo, D., Fernandes, M., Vaz, C., Alves, H., Barrera, P., Westhovens, R., Balsa, A., Migliorini, P., Michou, L., Dieudé, P., Teixeira, V.H., Annals of the Rheumatic Diseases, 2009, 10.1136/ard.2008.095380
  • Development of a molecular test of Paget's disease of bone, Michou, L., Brown, J.P., Orcel, P., Siris, E.S., Morissette, J., Gagnon, E., Albert, C., Bureau, A., Simonyan, D., Guay-Bélanger, S., Bone, 2016, 10.1016/j.bone.2016.01.007
  • Duration-Dependent Increase of Human Bone Matrix Mineralization in Long-Term Bisphosphonate Users with Atypical Femur Fracture, Boivin, G., Brown, J.P., Rao, S.D., Chapurlat, R.D., Chavassieux, P., Qiu, S., Morin, S.N., Michou, L., Ste-Marie, L.-G., Rizzo, S., Farlay, D., Journal of Bone and Mineral Research, 2021, 10.1002/jbmr.4244
  • Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone, Cancela, M.L., Michou, L., Gianfrancesco, F., Brown, J.P., Caiado, H., Gagnon, É., Conceição, N., Silva, I.A.L., Biochimica et Biophysica Acta - Molecular Basis of Disease, 2018, 10.1016/j.bbadis.2017.10.008
  • Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget’s disease of bone, , 1911
  • Assessment of the educational impact of an information leaflet on the knowledge of complications in systemic sclerosis, Michou, L., Fortin, P.R., Bessette, L., Brown, J.P., Beaudoin, C., Ikic, A., Joint Bone Spine, 2015, 10.1016/j.jbspin.2014.12.005
  • The TNFRSF1A R92Q mutation is frequent in rheumatoid arthritis but shows no evidence for association or linkage with the disease, Tchernitchko, D.O., Bardin, T., Michou, L., Cornélis, F., Goossens, M., Dieudé, P., Annals of the Rheumatic Diseases, 2007, 10.1136/ard.2006.060764

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Mariejka Beauregard - Maîtrise avec mémoire - 2013/05
  • Sabrina Guay-Bélanger - Doctorat - 2015/09
  • Mohamed Numan - Maîtrise avec mémoire - 2016/09
  • Mariam Dessay - Doctorat - 2020/05

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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