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Madeleine Carreau

Professeure titulaire

Madeleine.Carreau@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Oncologie
Médecine régénératrice et médecine moléculaire
Reproduction, génétique, périnatalité et développement

Domaines et intérêts de recherche du (de la) professeur(e) :

Santé de la mère, des enfants et des adolescents
  • Anomalies congénitales
Cancer
  • Apoptose et cancer
  • Cancer de la tête et du cou
  • Signalisation cellulaire et cancer
Cellulaire
  • Cellule
Organisation et fonctions biologiques

Projets de recherche

  • To understand the molecular basis of carcinogenesis in FA. - Fanconi Anemia Research Fund, Inc., chercheur principal - 2020-12-01 au 2023-11-30
  • Understanding Head and Neck Squamous Cell Carcinoma onset in young adults - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-10-01 au 2023-03-31

Publications

  • The Caenorhabditis elegans FancD2 ortholog is required for survival following DNA damage, Desnoyers, S., Carreau, M., Gagnon, S.N., St-Laurent, J.-F., Dequen, F., Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2005, 10.1016/j.cbpc.2005.05.010
  • Regulation of the Fanconi Anemia Group C Protein through Proteolytic Modification, Carreau, M., Lévesque, G., Buchwald, M., Khandjian, E.W., Huard, C., Godin, C., Delisle, M.-C., Charbonneau, C., Tremblay, C.S., Goulet, I., Brodeur, I., Journal of Biological Chemistry, 2004, 10.1074/jbc.M301291200
  • Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1, Carreau, M., Ĺevesque, G., Schindler, D., Delisle, M.-C., Helsper, K., Tremblay, C.S., Huard, C.C., Blood, 2013, 10.1182/blood-2012-02-408997
  • Presenilin-I is indirectly implicated in Notchl cleavage, Lévesque, G., Carreau, M., Hébert, S.S., Ferland, M., Auclair, A., Godin, C., NeuroReport, 2003, 10.1097/00001756-200308260-00014
  • Elevated blood levels of Dickkopf-1 are associated with acute infections, Carreau, M., Schindler, D., St-Louis, M., Larouche, V., Mazon, M., Immunity Inflammation and Disease, 2018, 10.1002/iid3.232
  • Not-so-novel phenotypes in the Fanconi anemia group D2 mouse model [3], Carreau, M., Blood, 2004, 10.1182/blood-2003-11-3946
  • Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac(-/-) mice, Clapp, D.W., Buchwald, M., Carreau, M., Hangoc, G., Cooper, S., Broxmeyer, H.E., Haneline, L.S., Blood, 1998
  • The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling, Carreau, M., Lévesque, G., Bourdages, V., Habi, O., Huang, F.-F., Huard, C.C., Tremblay, C.S., Journal of Biological Chemistry, 2009, 10.1074/jbc.M807921200
  • Correction of Fanconi Anemia Group C Hematopoietic Stem Cells Following Intrafemoral Gene Transfer, Madeleine Carreau, Marie-Chantal Delisle, Valérie Bourdages, Johanne Girard, Ouassila Habi, Anemia, 2010, 10.1155/2010/947816
  • Loss of FancC function results in decreased hematopoietic stem cell repopulating ability, Clapp, D.W., Yoder, M.C., Buchwald, M., Carreau, M., Ramani, R., Gobbett, T.A., Haneline, L.S., Blood, 1999, 10.1182/blood.v94.1.1.413k03_1_8
  • Deletion of the Fanconi Anemia C Gene in Mice Leads to Skeletal Anomalies and Defective Bone Mineralization and Microarchitecture, Carreau, M., Mac-Way, F., Frenette, J., Filiatrault, J., Tam, R., Hamoudi, D., Picard, S., Ung, R.-V., Julien, J., Mazon, M., Journal of Bone and Mineral Research, 2018, 10.1002/jbmr.3546
  • The Fanconi anemia C protein binds to and regulates stathmin-1 phosphorylation, Carreau, M., Elowe, S., Magron, A., PLoS ONE, 2015, 10.1371/journal.pone.0140612
  • Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1), Lévesque, G., Carreau, M., Ferland, M., Godin, C., Bourdages, V., Hébert, S.S., Neurobiology of Disease, 2003, 10.1016/S0969-9961(03)00035-4
  • Erratum: Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA (Nature Genetics (1996) 14 (320-323)), Joenje, H., Buchwald, M., Arwert, F., Pronk, J.C., Kruyt, F.A.E., Pals, G., Gille, J.J.P., Strunk, M.H.P., Van Berkel, C.G.M., Cheng, N.C., Savoia, A., Callen, D.F., Carreau, M., Lightfoot, J., Parker, L., Wijker, M., Alon, N., Bosnoyan-Collins, L., Rooimans, M.A., Foe, J.R.L.T., Nature Genetics, 1996, 10.1038/ng1296-488b
  • The Fanconi anemia genes, Buchwald, M., Carreau, M., Current Opinion in Pediatrics, 1998, 10.1097/00008480-199802000-00013
  • The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression, Carreau, M., Lévesque, G., Magron, A., Tremblay, C.S., Huard, C.C., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1314226111
  • Drug sensitivity spectra in Fanconi anemia lymphoblastoid cell lines of defined complementation groups, Buchwald, M., Joenje, H., Bosnoyan-Collins, L., Alon, N., Carreau, M., Mutation Research - DNA Repair, 1999, 10.1016/S0921-8777(99)00041-5
  • Hematopoietic compartment of Fanconi anemia group C null mice contains fewer lineage-negative CD34+ primitive hematopoietic cells and shows reduced reconstitution ability, Buchwald, M., Dick, J.E., Doedens, M., Liu, L., Gan, O.I., Carreau, M., Experimental Hematology, 1999, 10.1016/S0301-472X(99)00102-2
  • Bone marrow failure in the fanconi anemia group C mouse model after DNA damage, Buchwald, M., Dick, J.E., McKerlie, C., Doedens, M., Liu, L., Gan, O.I., Carreau, M., Blood, 1998, 10.1182/blood.v91.8.2737.2737_2737_2744
  • Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia, Buchwald, M., Joyner, A.L., Dick, J.E., Percy, D.H., Cross, J., Freedman, M.H., Guidos, C.J., Groves, T., Auerbach, A., Carreau, M., Gan, O., Liu, L., Youssoufian, H., McKerlie, C., Auerbach, W., Tomkins, D.J., Chen, M., Nature Genetics, 1996, 10.1038/ng0496-448
  • Fanconi's anemia: What have we learned from the genes so far?, Buchwald, M., Carreau, M., Molecular Medicine Today, 1998, 10.1016/S1357-4310(98)01243-X
  • HES1 is a novel interactor of the Fanconi anemia core complex, Carreau, M., Lévesque, G., Godin, C., Huard, C.C., Habi, O., Huang, F.F., Tremblay, C.S., Blood, 2008, 10.1182/blood-2008-04-152710
  • Short-term granulocyte colony-stimulating factor and erythropoietin treatment enhances hematopoiesis and survival in the mitomycin C-conditioned Fancc-/- mouse model, while long-term treatment is ineffective, Buchwald, M., Dick, J.E., Hitzler, J.K., Gan, O.I., Liu, L., Carreau, M., Blood, 2002, 10.1182/blood-2001-11-0007
  • Fanconi Anemia Proteins and Their Interacting Partners: A Molecular Puzzle, Madeleine Carreau, Tagrid Kaddar, Anemia, 2012, 10.1155/2012/425814
  • Hematopoietic stem cells from Fancc-/- mice have lower growth and differentiation potential in response to growth factors, Carreau, M., Goulet, I., Charbonneau, C., Lafrance, M., Aub́, M., Stem Cells, 2002, 10.1634/stemcells.20-5-438
  • The Fanconi anaemia group G gene FANCG is identical with XRCC9, Joenje, H., Buchwald, M., Digweed, M., Hoehn, H., Arwert, F., Pronk, J.C., Schindler, D., Demuth, I., Bender, O., Carreau, M., Alon, N., Bosnoyan-Collins, L., Van Berkel, C.G.M., Rooimans, M.A., Waisfisz, Q., De Winter, J.P., Nature Genetics, 1998, 10.1038/3093
  • Lack of self-renewal capacity in Fancc-/- stem cells after ex vivo expansion, Carreau, M., Messier, N., Delisle, M.-C., Habi, O., Stem Cells, 2005, 10.1634/stemcells.2004-0356
  • FANCC localizes with UNC5A at neurite outgrowth and promotes neuritogenesis, Carreau, M., Lévesque, G., Ben Aissa, M., Huang, F., BMC Research Notes, 2018, 10.1186/s13104-018-3763-1
  • Functional Retroviral Vector for Gene Therapy of Xeroderma Pigmentosum Group D Patients, Sarasin, A., Mezzina, M., Heard, J.-M., Danos, O., Salvetti, A., Eveno, E., Quilliet, X., Carreau, M., Human Gene Therapy, 1995, 10.1089/hum.1995.6.10-1307
  • Mitomycin C-induced DNA damage in Fanconi anemia: Cross-linking or redox-mediated effects? [7] (multiple letters), Buchwald, M., Carreau, M., Korkina, L.G., Zatterale, A., Pagano, G., Blood, 1999, 10.1182/blood.v93.3.1116
  • Naturally occurring FANCF-Hes1 complex inhibitors from Wrightia religiosa, Ishibashi, M., Carreau, M., Kaddar, T., Kowithayakorn, T., Koyano, T., Ishikawa, N., Hamahiga, N., Uemura, K., Arai, M.A., MedChemComm, 2015, 10.1039/c4md00495g
  • Development and characterization of immortalized fibroblastoid cell lines from an FA(C) mouse model, Buchwald, M., Carreau, M., Care, M., Tomkins, D.J., Mutation Research - DNA Repair, 1998, 10.1016/S0921-8777(98)00015-9
  • Development of a new easy complementation assay for DNA repair deficient human syndromes using cloned repair genes, Mezzina, M., Sarasin, A., Hoeijmakers, J.H.J., Vermeulen, W., Stefanini, M., Tanganelli, B., Benoit, A., Chevalier-lagente, O., Quilliet, X., Eveno, E., Carreau, M., Carcinogenesis, 1995, 10.1093/carcin/16.5.1003
  • Correction by the ercc2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells, Sarasin, A., A. Weber, C., Lehmann, A.R., Stefanini, M., Hoeijmakers, J.H.J., Vermeulen, W., Carreau, M., Benoit, A., Chevallier-lagente, O., Eveno, E., Mezzina, M., Carcinogenesis, 1994, 10.1093/carcin/15.8.1493
  • Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity, Carreau, M., Lévesque, G., Huang, F.F., Tremblay, C.S., BMC Research Notes, 2018, 10.1186/s13104-018-3243-7
  • Modulating Dickkopf-1: A strategy to monitor or treat cancer?, Carreau, M., Masi, D., Mazon, M., Cancers, 2016, 10.3390/cancers8070062
  • The fanconi anemia group C protein interacts with uncoordinated 5A and delays apoptosis, Carreau, M., Lévesque, G., Godin, C., Huard, C.C., Magron, A., Aissa, M.B., Huang, F., PLoS ONE, 2014, 10.1371/journal.pone.0092811
  • Expression cloning of a cdna for the major fanconi anaemia gene, FAA, Joenje, H., Buchwald, M., Arwert, F., Pronk, J.C., Kruyt, F.A.E., Pals, G., Gille, J.J.P., Strunk, M.H.P., Van Berkel, C.C.M., Cheng, N.C., Savoia, A., Callen, D.F., Carreau, M., Lightfoot, J., Parker, L., Wijker, M., Alon, N., Bosnoyan-Collins, L., Rooimans, M.A., Ten Foe, J.R.L., Nature Genetics, 1996, 10.1038/ng1196-320
  • Fanconi anemia genes are highly expressed in primitive CD34+ hematopoietic cells, Carreau, M., Delisle, M.-C., Brodeur, I., Lafrance, M., Aubé, M., BMC Blood Disorders, 2003, 10.1186/1471-2326-3-1

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Audrey Magron - Doctorat - 2015/01
  • Delphine Masi - Doctorat - 2017/09
  • Mélody Mazon - Doctorat - 2018/01

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Médecine moléculaire
  • Sciences cliniques et biomédicales

En savoir plus sur les programmes

Disponibilité d'encadrement d'étudiant(e)s

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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