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Madeleine Carreau

Professeure titulaire

Madeleine.Carreau@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine :

Oncologie
Médecine régénératrice et médecine moléculaire
Reproduction, génétique, périnatalité et développement

Financements des 2 dernières années

  • To understand the molecular basis of carcinogenesis in FA. - Fanconi Anemia Research Fund, Inc., chercheur principal - 2020-12-01 au 2023-11-30

Publications

  • Lack of self-renewal capacity in Fancc-/- stem cells after ex vivo expansion, Carreau, M., Messier, N., Delisle, M.-C., Habi, O., Stem Cells, 2005, 10.1634/stemcells.2004-0356
  • Fanconi's anemia: What have we learned from the genes so far?, Buchwald, M., Carreau, M., Molecular Medicine Today, 1998, 10.1016/S1357-4310(98)01243-X
  • Erratum: Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA (Nature Genetics (1996) 14 (320-323)), Joenje, H., Buchwald, M., Arwert, F., Pronk, J.C., Kruyt, F.A.E., Pals, G., Gille, J.J.P., Strunk, M.H.P., Van Berkel, C.G.M., Cheng, N.C., Savoia, A., Callen, D.F., Carreau, M., Lightfoot, J., Parker, L., Wijker, M., Alon, N., Bosnoyan-Collins, L., Rooimans, M.A., Foe, J.R.L.T., Nature Genetics, 1996, 10.1038/ng1296-488b
  • HES1 is a novel interactor of the Fanconi anemia core complex, Carreau, M., Lévesque, G., Godin, C., Huard, C.C., Habi, O., Huang, F.F., Tremblay, C.S., Blood, 2008, 10.1182/blood-2008-04-152710
  • Modulating Dickkopf-1: A strategy to monitor or treat cancer?, Carreau, M., Masi, D., Mazon, M., Cancers, 2016, 10.3390/cancers8070062
  • Development of a new easy complementation assay for DNA repair deficient human syndromes using cloned repair genes, Mezzina, M., Sarasin, A., Hoeijmakers, J.H.J., Vermeulen, W., Stefanini, M., Tanganelli, B., Benoit, A., Chevalier-lagente, O., Quilliet, X., Eveno, E., Carreau, M., Carcinogenesis, 1995, 10.1093/carcin/16.5.1003
  • Fanconi Anemia Proteins and Their Interacting Partners: A Molecular Puzzle, Madeleine Carreau, Tagrid Kaddar, Anemia, 2012, 10.1155/2012/425814
  • The Fanconi anemia C protein binds to and regulates stathmin-1 phosphorylation, Carreau, M., Elowe, S., Magron, A., PLoS ONE, 2015, 10.1371/journal.pone.0140612
  • Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia, Buchwald, M., Joyner, A.L., Dick, J.E., Percy, D.H., Cross, J., Freedman, M.H., Guidos, C.J., Groves, T., Auerbach, A., Carreau, M., Gan, O., Liu, L., Youssoufian, H., McKerlie, C., Auerbach, W., Tomkins, D.J., Chen, M., Nature Genetics, 1996, 10.1038/ng0496-448
  • Fanconi anemia core complex-dependent HES1 mono-ubiquitination regulates its transcriptional activity, Carreau, M., Lévesque, G., Huang, F.F., Tremblay, C.S., BMC Research Notes, 2018, 10.1186/s13104-018-3243-7
  • Bone marrow failure in the fanconi anemia group C mouse model after DNA damage, Buchwald, M., Dick, J.E., McKerlie, C., Doedens, M., Liu, L., Gan, O.I., Carreau, M., Blood, 1998, 10.1182/blood.v91.8.2737.2737_2737_2744
  • FANCC localizes with UNC5A at neurite outgrowth and promotes neuritogenesis, Carreau, M., Lévesque, G., Ben Aissa, M., Huang, F., BMC Research Notes, 2018, 10.1186/s13104-018-3763-1
  • Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1), Lévesque, G., Carreau, M., Ferland, M., Godin, C., Bourdages, V., Hébert, S.S., Neurobiology of Disease, 2003, 10.1016/S0969-9961(03)00035-4
  • Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1, Carreau, M., Ĺevesque, G., Schindler, D., Delisle, M.-C., Helsper, K., Tremblay, C.S., Huard, C.C., Blood, 2013, 10.1182/blood-2012-02-408997
  • Development and characterization of immortalized fibroblastoid cell lines from an FA(C) mouse model, Buchwald, M., Carreau, M., Care, M., Tomkins, D.J., Mutation Research - DNA Repair, 1998, 10.1016/S0921-8777(98)00015-9
  • Expression cloning of a cdna for the major fanconi anaemia gene, FAA, Joenje, H., Buchwald, M., Arwert, F., Pronk, J.C., Kruyt, F.A.E., Pals, G., Gille, J.J.P., Strunk, M.H.P., Van Berkel, C.C.M., Cheng, N.C., Savoia, A., Callen, D.F., Carreau, M., Lightfoot, J., Parker, L., Wijker, M., Alon, N., Bosnoyan-Collins, L., Rooimans, M.A., Ten Foe, J.R.L., Nature Genetics, 1996, 10.1038/ng1196-320
  • Naturally occurring FANCF-Hes1 complex inhibitors from Wrightia religiosa, Ishibashi, M., Carreau, M., Kaddar, T., Kowithayakorn, T., Koyano, T., Ishikawa, N., Hamahiga, N., Uemura, K., Arai, M.A., MedChemComm, 2015, 10.1039/c4md00495g
  • Hematopoietic compartment of Fanconi anemia group C null mice contains fewer lineage-negative CD34+ primitive hematopoietic cells and shows reduced reconstitution ability, Buchwald, M., Dick, J.E., Doedens, M., Liu, L., Gan, O.I., Carreau, M., Experimental Hematology, 1999, 10.1016/S0301-472X(99)00102-2
  • Correction by the ercc2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells, Sarasin, A., A. Weber, C., Lehmann, A.R., Stefanini, M., Hoeijmakers, J.H.J., Vermeulen, W., Carreau, M., Benoit, A., Chevallier-lagente, O., Eveno, E., Mezzina, M., Carcinogenesis, 1994, 10.1093/carcin/15.8.1493
  • The Fanconi anaemia group G gene FANCG is identical with XRCC9, Joenje, H., Buchwald, M., Digweed, M., Hoehn, H., Arwert, F., Pronk, J.C., Schindler, D., Demuth, I., Bender, O., Carreau, M., Alon, N., Bosnoyan-Collins, L., Van Berkel, C.G.M., Rooimans, M.A., Waisfisz, Q., De Winter, J.P., Nature Genetics, 1998, 10.1038/3093
  • The fanconi anemia group C protein interacts with uncoordinated 5A and delays apoptosis, Carreau, M., Lévesque, G., Godin, C., Huard, C.C., Magron, A., Aissa, M.B., Huang, F., PLoS ONE, 2014, 10.1371/journal.pone.0092811
  • Drug sensitivity spectra in Fanconi anemia lymphoblastoid cell lines of defined complementation groups, Buchwald, M., Joenje, H., Bosnoyan-Collins, L., Alon, N., Carreau, M., Mutation Research - DNA Repair, 1999, 10.1016/S0921-8777(99)00041-5
  • The Caenorhabditis elegans FancD2 ortholog is required for survival following DNA damage, Desnoyers, S., Carreau, M., Gagnon, S.N., St-Laurent, J.-F., Dequen, F., Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2005, 10.1016/j.cbpc.2005.05.010
  • Fanconi anemia genes are highly expressed in primitive CD34+ hematopoietic cells, Carreau, M., Delisle, M.-C., Brodeur, I., Lafrance, M., Aubé, M., BMC Blood Disorders, 2003, 10.1186/1471-2326-3-1
  • Not-so-novel phenotypes in the Fanconi anemia group D2 mouse model [3], Carreau, M., Blood, 2004, 10.1182/blood-2003-11-3946
  • Presenilin-I is indirectly implicated in Notchl cleavage, Lévesque, G., Carreau, M., Hébert, S.S., Ferland, M., Auclair, A., Godin, C., NeuroReport, 2003, 10.1097/00001756-200308260-00014
  • Mitomycin C-induced DNA damage in Fanconi anemia: Cross-linking or redox-mediated effects? [7] (multiple letters), Buchwald, M., Carreau, M., Korkina, L.G., Zatterale, A., Pagano, G., Blood, 1999, 10.1182/blood.v93.3.1116
  • Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac(-/-) mice, Clapp, D.W., Buchwald, M., Carreau, M., Hangoc, G., Cooper, S., Broxmeyer, H.E., Haneline, L.S., Blood, 1998
  • The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression, Carreau, M., Lévesque, G., Magron, A., Tremblay, C.S., Huard, C.C., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1314226111
  • Short-term granulocyte colony-stimulating factor and erythropoietin treatment enhances hematopoiesis and survival in the mitomycin C-conditioned Fancc-/- mouse model, while long-term treatment is ineffective, Buchwald, M., Dick, J.E., Hitzler, J.K., Gan, O.I., Liu, L., Carreau, M., Blood, 2002, 10.1182/blood-2001-11-0007
  • Deletion of the Fanconi Anemia C Gene in Mice Leads to Skeletal Anomalies and Defective Bone Mineralization and Microarchitecture, Carreau, M., Mac-Way, F., Frenette, J., Filiatrault, J., Tam, R., Hamoudi, D., Picard, S., Ung, R.-V., Julien, J., Mazon, M., Journal of Bone and Mineral Research, 2018, 10.1002/jbmr.3546
  • Correction of Fanconi Anemia Group C Hematopoietic Stem Cells Following Intrafemoral Gene Transfer, Madeleine Carreau, Marie-Chantal Delisle, Valérie Bourdages, Johanne Girard, Ouassila Habi, Anemia, 2010, 10.1155/2010/947816
  • Hematopoietic stem cells from Fancc-/- mice have lower growth and differentiation potential in response to growth factors, Carreau, M., Goulet, I., Charbonneau, C., Lafrance, M., Aub́, M., Stem Cells, 2002, 10.1634/stemcells.20-5-438
  • Loss of FancC function results in decreased hematopoietic stem cell repopulating ability, Clapp, D.W., Yoder, M.C., Buchwald, M., Carreau, M., Ramani, R., Gobbett, T.A., Haneline, L.S., Blood, 1999, 10.1182/blood.v94.1.1.413k03_1_8
  • Regulation of the Fanconi Anemia Group C Protein through Proteolytic Modification, Carreau, M., Lévesque, G., Buchwald, M., Khandjian, E.W., Huard, C., Godin, C., Delisle, M.-C., Charbonneau, C., Tremblay, C.S., Goulet, I., Brodeur, I., Journal of Biological Chemistry, 2004, 10.1074/jbc.M301291200
  • The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling, Carreau, M., Lévesque, G., Bourdages, V., Habi, O., Huang, F.-F., Huard, C.C., Tremblay, C.S., Journal of Biological Chemistry, 2009, 10.1074/jbc.M807921200
  • The Fanconi anemia genes, Buchwald, M., Carreau, M., Current Opinion in Pediatrics, 1998, 10.1097/00008480-199802000-00013
  • Elevated blood levels of Dickkopf-1 are associated with acute infections, Carreau, M., Schindler, D., St-Louis, M., Larouche, V., Mazon, M., Immunity Inflammation and Disease, 2018, 10.1002/iid3.232
  • Functional Retroviral Vector for Gene Therapy of Xeroderma Pigmentosum Group D Patients, Sarasin, A., Mezzina, M., Heard, J.-M., Danos, O., Salvetti, A., Eveno, E., Quilliet, X., Carreau, M., Human Gene Therapy, 1995, 10.1089/hum.1995.6.10-1307

Contribution à l'enseignement aux cycles supérieurs

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Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Médecine moléculaire
  • Sciences cliniques et biomédicales

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