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Martin Pelletier

Professeur agrégé

Martin Pelletier
martin.pelletier.21@ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie
Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
  • Arthrite/arthrose
Maladies infectieuses et immunitaires
  • Maladies auto-immunes
  • Maladies du système immunitaire
  • Médiateurs immunologiques : cytokines et chimiokines
  • Système immunitaire
Nutrition et métabolisme
  • Maladie de Crohn
  • Métabolisme
  • Métabolisme énergétique
  • Toxicologie

Projets de recherche

  • Metabolic mechanisms of pro-resolutive neutrophils in chronic inflammatory diseases - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2024-04-01 au 2029-03-31
  • Mechanisms Involved in the Modulation of Cellular Metabolism and Functional Responses by EndocrineDisrupting - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2023-04-01 au 2028-03-31
  • Surveillance des réponses immunitaires au vaccin contre la COVID-19 chez les personnes vivant avec le VIH-1 - Instituts de recherche en santé du Canada - Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-12-01 au 2022-11-30

Publications

  • Platelet extracellular vesicles and their mitochondrial content improve the mitochondrial bioenergetics of cellular immune recipients, Eric Boilard, Tom Benson, Yann Becker, Isabelle Allaeys, Yann Breton, Martin Pelletier, Transfusion, 2023, 10.1111/trf.17524
  • Activation of human neutrophils in vitro and dieldrin-induced neutrophilic inflammation in vivo, Girard, D., Tessier, P.A., Vandal, K., Gauthier, M., Roberge, C.J., Pelletier, M., Journal of Leukocyte Biology, 2001
  • S100A9 induces differentiation of acute myeloid leukemia cells through TLR4, Frédéric Barabé, Philippe A. Tessier, Martin Pelletier, Asmaa Lachhab, Marie-Astrid Raquil, Laurine Gil, Mélanie R. Tardif, Malika Laouedj, Blood, 2017, 10.1182/blood-2016-09-738005
  • Impact of Endocrine Disruptors on the Genitourinary Tract, Martin Pelletier, Stéphane Bolduc, François Bordeleau, Stéphane Chabaud, Felix-Antoine Pellerin, Sarah-Maude Goulet, Elena Lonina, Laurence Carignan, Christophe Caneparo, Journal of Xenobiotics, 2024, 10.3390/jox14040099
  • Metabolic regulation of neutrophil functions in homeostasis and diseases, Martin Pelletier, Philippe A Tessier, Patrice E Poubelle, Sylvain G Bourgoin, Pier-Olivier Leblanc, Journal of Leukocyte Biology, 2024, 10.1093/jleuko/qiae025
  • Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects, Sack, M.N., Siegel, R.M., Sauve, A.A., Pelletier, M., Han, K., Waclawiw, M.A., Bray, A., Huffstutler, R.D., Li, J., Okoli, T.C., Kwarteng-Siaw, M., Traba, J., Journal of Clinical Investigation, 2015, 10.1172/JCI83260
  • Functional responses of human neutrophils to sodium sulfite (Na2SO3) in vitro, Girard, D., Omara, F.O., Pelletier, M., Labbé, P., Human and Experimental Toxicology, 1998, 10.1177/096032719801701103
  • The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells, Siegel, R.M., McKenzie, A.N.J., Wynn, T.A., Paul, W.E., Chen, X., Gomez-Rodriguez, J., Hayes, E.T., Richard, A.C., Sciumè, G., Pelletier, M., Penumetcha, P., Barlow, J.L., Barron, L., Hawley, E.T., Meylan, F., Mucosal Immunology, 2014, 10.1038/mi.2013.114
  • Le profil de sécrétion de cytokines par les leucocytes sanguins aide au diagnostic et au traitement des patients atteints de maladies auto-inflammatoires, Pelletier, M., Tessier, P., Leclerc, M., Pagé, N., Longchamps, M.P., Nézondet-Chetaille, A.L., Revue du Rhumatisme (Edition Francaise), 2016, 10.1016/S1169-8330(16)30609-3
  • Erratum: Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type i IFN production (Journal of Clinical Investigation (2015) 125:11 (4196-4211) DOI: 10.1172/JCI81260), Goldbach-Mansky, R., Aksentijevich, I., Krüger, E., Brogan, P., Hildebrand, P.W., Rother, K.I., Wesley, R., McCoy, P., Gadina, M., Moir, S., Zlotogorski, A., Torrelo, A., Kastner, D.L., Lee, C.-C.R., Sotzny, F., Chen, Y., Stone, D., Huang, Y., Chapelle, D., Gao, L., Casano, A.V., Brown, D., Castillo, R.D., Brady, J., Chae, J.J., Megarbane, A., Lachmann, H.J., Kim, H., Hill, S., Kardava, L., Remmers, E.F., Tsai, W.L., Pelletier, M., De Jesus, A.A., Reinhardt, A., Biancotto, A., Montealegre, G., Zhou, Q., Omoyinmi, E., Marrero, B., Sheikh, A., Liu, Y., Brehm, A., Journal of Clinical Investigation, 2016, 10.1172/JCI86020
  • The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity, Martin Pelletier, Cindy Peillex, Journal of Immunotoxicology, 2020, 10.1080/1547691X.2020.1804492
  • Interleukin-15 increases neutrophil adhesion onto human respiratory epithelial A549 cells and attracts neutrophils in vivo, Girard, D., Pelletier, M., Clinical and Experimental Immunology, 2005, 10.1111/j.1365-2249.2005.02861.x
  • Activation of human neutrophils by technical toxaphene, Girard, D., Tessier, P.A., Pelletier, M., Roberge, C.J., Gauthier, M., Clinical Immunology, 2001, 10.1006/clim.2000.4946
  • Bisphenol A, bisphenol S and their glucuronidated metabolites modulate glycolysis and functional responses of human neutrophils, Martin Pelletier, Asmaa Lachhab, Anthony Kerever, Cindy Peillex, Environmental Research, 2021, 10.1016/j.envres.2020.110336
  • Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations, Boilard, E., Fortin, P.R., Rauch, J., Dieudé, M., Hébert, M.-J., Belleannée, C., Tremblay, M.-È., Hajj, H.E., Pelletier, M., Wagner, É., Eder, L., Melki, I., Cloutier, N., Benk-Fortin, H., Rollet-Labelle, E., Lévesque, T., Allaeys, I., Marcoux, G., Julien, A.-S., Loignon, R.-C., Becker, Y., Scientific Reports, 2019, 10.1038/s41598-019-40900-3
  • Heat-Inactivation of Fetal and Newborn Sera Did Not Impair the Expansion and Scaffold Engineering Potentials of Fibroblasts, Stéphane Bolduc, Martin Pelletier, Stéphane Chabaud, Ève Pellerin, Christophe Caneparo, Félix-Antoine Pellerin, Bioengineering, 2021, 10.3390/bioengineering8110184
  • Molecular mechanisms involved in interleukin-4-induced human neutrophils: Expression and regulation of suppressor of cytokine signaling, Girard, D., Chiasson, S., Pelletier, M., Ratthé, C., Journal of Leukocyte Biology, 2007, 10.1189/jlb.0306209
  • Tumor-associated macrophages enhance tumor hypoxia and aerobic glycolysis, Ahn, G.-O., Jeon, Y.K., Chung, D.H., Weissman, I.L., Cheon, G.J., Lee, J.S., Lee, Y.-S., Park, J.-W., Kim, H.J., Kim, I.H., Kim, D.-W., Lee, Y.-J., Kim, S., Ju, J.H., Kim, K.H., Kim, B., Roh, T.-Y., Jeon, H., Pelletier, M., Tessier, P., Defrêne, J., Chung, S.-J., Lee, M.S., Yoo, M.Y., Gwak, S.-H., Oh, J.-M., Bok, S., Kim, Y.-E., Lee, C.-J., Hong, B.-J., Kim, S., Jeong, H., Cancer Research, 2019, 10.1158/0008-5472.CAN-18-2545
  • The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells, Meylan, F., Siegel, R.M., Gery, I., Kaplan, M.H., Al-Shamkhani, A., O'Shea, J.J., Choi, Y., Keane-Myers, A., Walsh, M., Ferdinand, J.R., Gabay, O., Pelletier, M., Hayes, E.T., Penumetcha, P., Cruz, A.C., Yang, X.-P., Goswami, R., Gomez-Rodriguez, J., Hawley, E.T., Tan, C., Richard, A.C., Journal of Immunology, 2015, 10.4049/jimmunol.1401220
  • Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS), Siegel, R.M., Kastner, D.L., Sack, M.N., Kim, K.-Y., Park, H., Pelletier, M., Maddipati, R., Simon, A., Bulua, A.C., Journal of Experimental Medicine, 2011, 10.1084/jem.20102049
  • Activation of human neutrophils by the pollutant sodium sulfite: Effect on cytokine production, chemotaxis, and cell surface expression of cell adhesion molecules, Girard, D., Roberge, C.J., Pelletier, M., Ratthé, C., Clinical Immunology, 2002, 10.1006/clim.2002.5282
  • Modulation of human neutrophil survival and antigen expression by activated CD4+ and CD8+ T cells, Cassatella, M.A., Micheletti, A., Pelletier, M., Journal of Leukocyte Biology, 2010, 10.1189/jlb.0310172
  • Mechanisms involved in spontaneous and Viscum album agglutinin-I-induced human neutrophil apoptosis: Viscum album agglutinin-I accelerates the loss of antiapoptotic Mcl-1 expression and the degradation of cytoskeletal paxillin and vimentin proteins via caspases, Girard, D., Hostanska, K., Saller, R., Pelletier, M., Lavastre, V., Journal of Immunology, 2002, 10.4049/jimmunol.168.3.1419
  • In vivo and in vitro roles of IL-21 in inflammation, Girard, D., Bouchard, A., Pelletier, M., Journal of Immunology, 2004, 10.4049/jimmunol.173.12.7521
  • S100A9 potentiates the activation of neutrophils by the etiological agent of gout, monosodium urate crystals, Fernandes, M., Pelletier, M., Tessier, P., Marceau, F., Naccache, P.H., Lachhab, A., Paré, G., Rousseau, L.-S., Journal of Leukocyte Biology, 2017, 10.1189/jlb.3MA0117-020R
  • Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type i IFN production, Goldbach-Mansky, R., Aksentijevich, I., Krüger, E., Brogan, P., Hildebrand, P.W., Rother, K., Wesley, R., McCoy, P., Gadina, M., Moir, S., Zlotogorski, A., Torrelo, A., Kastner, D.L., Lee, C.-C.R., Sotzny, F., Chen, Y., Stone, D., Huang, Y., Chapelle, D., Gao, L., Casano, A.V., Brown, D., Castillo, R.D., Brady, J., Chae, J.J., Megarbane, A., Lachmann, H.J., Kim, H., Hill, S., Kardava, L., Remmers, E.F., Tsai, W.L., Pelletier, M., De Jesus, A.A., Reinhardt, A., Biancotto, A., Montealegre, G., Zhou, Q., Omoyinmi, E., Marrero, B., Sheikh, A., Liu, Y., Brehm, A., Journal of Clinical Investigation, 2015, 10.1172/JCI81260
  • Biological functions of interleukin-21 and its role in inflammation, Girard, D., Pelletier, M., TheScientificWorldJournal, 2007, 10.1100/tsw.2007.275
  • Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease, Hanson, E.P., Siegel, R.M., Orange, J.S., Ashwell, J.D., Cheng, L., Lee, Y., Vonortas, S., Tsai, W.L., Pelletier, M., Luo, Y., Wessel, A.W., Shawver, L.M., Zilberman-Rudenko, J., Proceedings of the National Academy of Sciences of the United States of America, 2016, 10.1073/pnas.1518163113
  • Sodium sulfite increases the production of interleukin-8 (IL-8) but not tumor necrosis factor-alpha (TNF-α) in human neutrophils, Girard, D., Pelletier, M., Savoie, A., Journal of Investigative Medicine, 1999
  • Glucuronidated Metabolites of Bisphenols A and S Alter the Properties of Normal Urothelial and Bladder Cancer Cells, Stéphane Bolduc, Martin Pelletier, Frédéric Pouliot, Stéphane Chabaud, Félix-Antoine Pellerin, Ève Pellerin, International Journal of Molecular Sciences, 2022, 10.3390/ijms232112859
  • Mechanisms involved in interleukin-15-induced suppression of human neutrophil apoptosis: Role of the anti-apoptotic Mcl-1 protein and several kinases including Janus kinase-2, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2, Girard, D., Ratthé, C., Pelletier, M., FEBS Letters, 2002, 10.1016/S0014-5793(02)03668-2
  • Activation of human epithelial lung A549 cells by the pollutant sodium sulfite: Enhancement of neutrophil adhesion, Girard, D., Lavastre, V., Pelletier, M., Toxicological Sciences, 2002, 10.1093/toxsci/69.1.210
  • Activation of human neutrophils by the plant lectin Viscum album agglutinin-I: Modulation of de novo protein synthesis and evidence that caspases are involved in induction of apoptosis, Girard, D., Hostanska, K., Hajto, T., Pelletier, M., Lavastre, V., Savoie, A., Journal of Leukocyte Biology, 2000
  • New tricks from an old dog: Mitochondrial redox signaling in cellular inflammation, Siegel, R.M., Murphy, M.P., Billingham, L.K., Lepow, T.S., Pelletier, M., Seminars in Immunology, 2012, 10.1016/j.smim.2013.01.002
  • Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression, Stéphane Bolduc, Martin Pelletier, Frédéric Pouliot, Stéphane Chabaud, Ève Pellerin, Cancers, 2021, 10.3390/cancers13215461
  • Estrogens and endocrine-disrupting chemicals differentially impact the bioenergetic fluxes of mammary epithelial cells in two- and three-dimensional models, Étienne Audet-Walsh, Martin Pelletier, Lucas Germain, Sarah-Maude Goulet, Cindy Weidmann, Yann Breton, Aurélie Lacouture, Environment International, 2023, 10.1016/j.envint.2023.108132
  • Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial, , The Lancet Respiratory Medicine, 2021, 10.1016/s2213-2600(21)00222-8
  • The impact of the herbicide glyphosate and its metabolites AMPA and MPA on the metabolism and functions of human blood neutrophils and their sex-dependent effects on reactive oxygen species and CXCL8/IL-8 production, Martin Pelletier, Philippe A. Tessier, Florence Léveillé, Yann Breton, Pier-Olivier Leblanc, Environmental Research, 2024, 10.1016/j.envres.2024.118831
  • Dieldrin induces human neutrophil superoxide production via protein kinases C and tyrosine kinases, Girard, D., Pelletier, M., Human and Experimental Toxicology, 2002, 10.1191/0960327102ht272oa
  • Wishing away inflammation? New links between serotonin and TNF signaling, Siegel, R.M., Pelletier, M., Molecular Interventions, 2009, 10.1124/mi.9.6.5
  • Extracellular flux analysis to monitor glycolytic rates and mitochondrial oxygen consumption, Siegel, R.M., Ramaswamy, M., Billingham, L.K., Pelletier, M., Methods in Enzymology, 2014, 10.1016/B978-0-12-416618-9.00007-8
  • Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection, Yasmine Belkaid, Richard M. Siegel, Thirumalai R. Ramalingam, Michelle Ploch, Joseph F. Urban, Jr., Sean P. Spencer, Martin Pelletier, Vanessa Schmitt, Oliver J. Harrison, Christoph Wilhelm, Journal of Experimental Medicine, 2016, 10.1084/jem.20151448
  • Toxaphene, but not beryllium, induces human neutrophil chemotaxis and apoptosis via reactive oxygen species (ROS): Involvement of caspases and ROS in the degradation of cytoskeletal proteins, Girard, D., Gauthier, M., Roberge, C.J., Pelletier, M., Lavastre, V., Clinical Immunology, 2002, 10.1006/clim.2002.5226
  • Impacts of endocrine-disrupting chemicals on prostate function and cancer, Étienne Audet-Walsh, Martin Pelletier, Cindy Peillex, Camille Lafront, Aurélie Lacouture, Environmental Research, 2022, 10.1016/j.envres.2021.112085
  • Endocrine-disrupting effects of bisphenols on urological cancers, Martin Pelletier, Stéphane Bolduc, Stéphane Chabaud, Christophe Caneparo, Eve Pellerin, Environmental Research, 2021, 10.1016/j.envres.2020.110485
  • Activation of superoxide production by promyelocytic HL-60 cells with sodium sulfite, Girard, D., Pelletier, M., Journal of Investigative Medicine, 1999
  • Differential effects of IL-15 and IL-21 in myeloid (CD11b+) and lymphoid (CD11b-) bone marrow cells, Girard, D., Pelletier, M., Journal of Immunology, 2006, 10.4049/jimmunol.177.1.100
  • Expression of the myeloid inhibitory receptor CLEC12A correlates with disease activity and cytokines in early rheumatoid arthritis, Maria J. Fernandes, Paul R. Fortin, Laëtitia Michou, Louis Bessette, Philippe A. Tessier, Martin Pelletier, Nathalie Amiable, Anne-Sophie Julien, Anthony Kerever, Asmaa Lachhab, Nathalie Pagé, Guillaume Paré, Philippe Desaulniers, Myriam Vaillancourt, Scientific Reports, 2021, 10.1038/s41598-021-90631-7
  • Toll-like receptor-3-activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophils, Krampera, M., Pizzolo, G., Pelletier, M., Calzetti, F., Cont, C., Tamassia, N., Lisi, V., Micheletti, A., Mosna, F., Cassatella, M.A., Stem Cells, 2011, 10.1002/stem.651
  • Modulation of interleukin-15-induced human neutrophil responses by the plant lectin Viscum album agglutinin-I, Girard, D., Hostanska, K., Saller, R., Ratthé, C., Savoie, A., Lavastre, V., Pelletier, M., Clinical Immunology, 2001, 10.1006/clim.2001.5105
  • Evidence for a cross-talk between human neutrophils and Th17 cells, Cassatella, M.A., Romagnani, S., Annunziato, F., Lunardi, C., Cosmi, L., Costantini, C., Tamassia, N., Lazzeri, E., Micheletti, A., Maggi, L., Pelletier, M., Blood, 2010, 10.1182/blood-2009-04-216085
  • Bisphenols A and S Alter the Bioenergetics and Behaviours of Normal Urothelial and Bladder Cancer Cells, Martin Pelletier, Stéphane Bolduc, Frédéric Pouliot, Stéphane Chabaud, Félix-Antoine Pellerin, Ève Pellerin, Cancers, 2022, 10.3390/cancers14164011
  • Human neutrophils interact with both 6-sulfo LacNAc+ DC and NK cells to amplify NK-derived IFNγ: Role of CD18, ICAM-1, and ICAM-3, Cassatella, M.A., Albanesi, C., Vermi, W., Facchetti, F., Pizzolo, G., Schakel, K., Pelletier, M., Lonardi, S., Scarponi, C., Micheletti, A., Perbellini, O., Calzetti, F., Costantini, C., Blood, 2011, 10.1182/blood-2010-06-287243
  • Activation of human neutrophils by the air pollutant sodium sulfite (NA2SO3): Comparison with immature promyelocytic HL-60 and DMSO-differentiated HL-60 cells reveals that NA2SO3 is a neutrophil but not a HL-60 cell agonist, Girard, D., Savoie, A., Pelletier, M., Clinical Immunology, 2000, 10.1006/clim.2000.4883
  • The use of leukocytes’ secretome to individually target biological therapy in autoimmune arthritis: a case report, Martin Pelletier, Philippe A. Tessier, Ivona Aksentijevich, David B. Beck, Natalia Sampaio Moura, Marie‐Pier Longchamps, Nathalie Pagé, Patrice E. Poubelle, Clinical and Translational Medicine, 2019, 10.1186/s40169-019-0236-7
  • The evaluation of cytokines to help establish diagnosis and guide treatment of autoinflammatory and autoimmune diseases, Martin Pelletier, Patrice E Poubelle, Anne-Laure Chetaille Nézondet, Journal of Leukocyte Biology, 2020, 10.1002/JLB.5MR0120-218RRR
  • Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9, Philippe A. Tessier, Denis Girard, Jean-Christophe Simard, Martin Pelletier, Blood Advances, 2018, 10.1182/bloodadvances.2018016667
  • Angiopoietin chemotactic activities on neutrophils are regulated by PI-3K activation, Sirois, M.G., Girard, D., Pelletier, M., Brkovic, A., Journal of Leukocyte Biology, 2007, 10.1189/jlb.0906580
  • Human neutrophil gene expression could be modulated by chemicals of environmental concern, Girard, D., Savoie, A., Pelletier, M., Journal of Investigative Medicine, 1999

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Sarah-Maude Tremblay - Maîtrise avec mémoire - En cours
  • Sarah-Maude Goulet - Maîtrise avec mémoire - En cours
  • Elena Lonina - Maîtrise avec mémoire - En cours
  • Émilie Mercure - Maîtrise avec mémoire - En cours
  • Jules Gignac - Maîtrise avec mémoire - En cours
  • Louis-Simon Rousseau - Maîtrise avec mémoire - 2017/09
  • Anthony Kerever - Maîtrise avec mémoire - 2018/09
  • Marie-Pier Longchamps - Maîtrise avec mémoire - 2019/01
  • Eve Pellerin - Maîtrise avec mémoire - 2022/09
  • Pier-Olivier Leblanc - Maîtrise avec mémoire - 2024/05
  • Emma Bourgeault - Maîtrise avec mémoire - 2024/05

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Microbiologie-immunologie

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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