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Martin Simard

Professeur titulaire

Martin Simard
martin.simard@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Oncologie

Domaines de recherche

  • Génétique moléculaire
  • Biologie cellulaire et moléculaire des animaux
  • Cibles moléculaires du cancer
  • Mécanismes de la carcinogenèse
  • Métastases et progression du cancer

Projets de recherche en cours

  • Toward understanding the role of tRNA-derived small RNAs in animals - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2025-04-01 au 2030-03-31
  • Deciphering cellular modulators of the microRNA pathway - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2024-10-01 au 2029-09-30
  • Understanding the regulation and implication of Argonaute in microRNA-mediated gene silencing. - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-10-01 au 2025-09-30

Financements des 2 dernières années

  • Genetic and molecular analysis of the siRNA-mediated gene regulation - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2019-04-01 au 2024-03-31
  • Deciphering cellular modulators of the microRNA pathway - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-03-01 au 2024-02-29
  • Canadian Developmental Biology Conference - Instituts de recherche en santé du Canada - Subventions de planification et dissémination – Programme d’appui communautaire des instituts, University of Toronto, co-chercheur - 2023-01-01 au 2023-12-31

Publications

  • A novel mutation in the neurofibromatosis type 1 (NF1) gene promotes skipping of two exons by preventing exon definition, Thirion, J.-P., Chabot, B., Vidaud, M., Lemieux, B., Assouline, B., Vidaud, D., Simard, M.J., Fang, L.J., Journal of Molecular Biology, 2001, 10.1006/jmbi.2001.4561
  • The Decapping Scavenger Enzyme DCS-1 Controls MicroRNA Levels in Caenorhabditis elegans, Simard, M.J., Großhans, H., Ambros, V.R., Rondeau, E.L., Vasquez-Rifo, A., Ow, M.C., Rüegger, S., Bossé, G.D., Molecular Cell, 2013, 10.1016/j.molcel.2013.02.023
  • Regulation and different functions of the animal microRNA‐induced silencing complex, Martin J. Simard, Pierre‐Marc Frédérick, WIREs RNA, 2022, 10.1002/wrna.1701
  • Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression, Huot, J., Royal, I., Simard, M.J., Paquet, É.R., Guillonneau, M., Fournier, P., Houle, F., Pin, A.-L., Journal of Biological Chemistry, 2012, 10.1074/jbc.M112.393561
  • Apoptosis-like programmed cell death induces antisense ribosomal RNA (rRNA) fragmentation and rRNA degradation in Leishmania, Papadopoulou, B., Simard, M.J., Cloutier, S., Samant, M., Padmanabhan, P.K., Cell Death and Differentiation, 2012, 10.1038/cdd.2012.85
  • Defining the contribution of microRNA-specific Argonautes with slicer capability in animals, Martin J Simard, Allison L Abbott, Miguel Quévillon Huberdeau, Katherine A Maniates, Michael Lantin, François Houle, Vaishnav Vasudevan, Anisha Pal, Nucleic Acids Research, 2024, 10.1093/nar/gkae173
  • Heterogeneous nuclear ribonucleoprotein particle A/B proteins and the control of alternative splicing of the mammalian heterogeneous nuclear ribonucleoprotein particle A1 pre-mRNA., Simard, M.J., Nasim, F.H., Hutchison, S., LeBel, C., Chabot, B., Progress in molecular and subcellular biology, 2003
  • TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells, Hansen, D., Simard, M.J., Wang, X., Bossé, G.D., Fressigne, L., Gupta, P., Wang, C., Nucleic acids research, 2017, 10.1093/nar/gkw836
  • The decapping scavenger enzyme DCS-1: A new modulator of miRNA turnover, Simard, M.J., Bossé, G.D., Meziane, O., Cell Cycle, 2013, 10.4161/cc.26076
  • A New Role for the GARP Complex in MicroRNA-Mediated Gene Regulation, Simard, M.J., Dallaire, A., Jannot, G., Rondeau, E.L., Bossé, G.D., Vasquez-Rifo, A., PLoS Genetics, 2013, 10.1371/journal.pgen.1003961
  • Argonaute proteins: Key players in RNA silencing, Simard, M.J., Hutvagner, G., Nature Reviews Molecular Cell Biology, 2008, 10.1038/nrm2321
  • Role for miR-204 in human pulmonary arterial hypertension, Bonnet, S., Simard, M.J., Côté, J., Provencher, S., Biardel, S., Paquet, E.R., Meloche, J., Perreault, T., Saksouk, N., Giguère, N.J., Paulin, R., Courboulin, A., Journal of Experimental Medicine, 2011, 10.1084/jem.20101812
  • Somatic and Germline MicroRNAs Form Distinct Silencing Complexes to Regulate Their Target mRNAs Differently, Martin J. Simard, Pierre-Marc Frédérick, Alexandra Dallaire, Developmental Cell, 2018, 10.1016/j.devcel.2018.08.022
  • Function, targets, and evolution of Caenorhabditis elegans piRNAs, Miska, E.A., Simard, M.J., Lehrbach, N.J., Bouasker, S., Weick, E.-M., Sapetschnig, A., Goldstein, L.D., Bagijn, M.P., Science, 2012, 10.1126/science.1220952
  • SRp30c is a repressor of 3′ splice site utilization, Chabot, B., Simard, M.J., Molecular and Cellular Biology, 2002, 10.1128/MCB.22.12.4001-4010.2002
  • Tumour-related microRNAs functions in Caenorhabditis elegans, Simard, M.J., Jannot, G., Oncogene, 2006, 10.1038/sj.onc.1209921
  • Novel Features of a PIWI-Like Protein Homolog in the Parasitic Protozoan Leishmania, Papadopoulou, B., Simard, M.J., Rochette, A., Samant, M., Dumas, C., Padmanabhan, P.K., PLoS ONE, 2012, 10.1371/journal.pone.0052612
  • Sequence-specific inhibition of small RNA function, Zamore, P.D., Mello, C.C., Simard, M.J., Hutvágner, G., PLoS Biology, 2004, 10.1371/journal.pbio.0020098
  • GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis, Simard, M.J., Nakanishi, K., McJunkin, K., Piquet, S., Brackbill, J.A., Morel-Berryman, L., Quévillon Huberdeau, M., Michaud, P., Jannot, G., PLoS Genetics, 2016, 10.1371/journal.pgen.1006484
  • Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging, Lebel, M., Simard, M.J., de Cabo, R.D., Mitchell, S.J., Paquet, E.R., Garand, C., Dallaire, A., Aging, 2012
  • MIR-20a represses endothelial cell migration by targeting MKK3 and inhibiting p38 MAP kinase activation in response to VEGF, Huot, J., Simard, M.J., Paquet, E.R., Guillonneau, M., Houle, F., Pin, A.-L., Angiogenesis, 2012, 10.1007/s10456-012-9283-z
  • The human decapping scavenger enzyme DcpS modulates microRNA turnover, Simard, M.J., Tones, M.A., Robert, C., Paquet, E., Gagné, D., Bossé, G.D., Piquet, S., Meziane, O., Scientific Reports, 2015, 10.1038/srep16688
  • A guide to microRNA‐mediated gene silencing, Martin J. Simard, Miguel Quévillon Huberdeau, The FEBS Journal, 2019, 10.1111/febs.14666
  • Relationship between the development of bronchial hyperresponsiveness and the airway eosinophilia in guinea pigs following injection with Sephadex beads, Sirois, P., Arseneault, D., Cloutier, S., Simard, M.J., Maghni, K., Inflammation Research, 1995, 10.1007/BF01778318
  • Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA-guided gene silencing in vivo, Meister, G., Simard, M.J., Deutzmann, R., Jannot, G., Engelmann, J.C., Strieder, N., Piquet, S., Danner, J., Fressigné, L., Bruckmann, A., Hauptmann, J., Zeitler, D.M., Quévillon Huberdeau, M., EMBO Journal, 2017, 10.15252/embj.201696386
  • The slicing activity of miRNA-specific Argonautes is essential for the miRNA pathway in C. elegans, Simard, M.J., Bouasker, S., Nucleic Acids Research, 2012, 10.1093/nar/gks748
  • Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span, Lebel, M., Simard, M.J., Proulx, S., Dallaire, A., BMC Genomics, 2014, 10.1186/1471-2164-15-940
  • Biogenesis of small non-coding RNAs in animals | La biogenèse des ARN courts non codants chez les animaux, Simard, M.J., Fressigné, L., Medecine/Sciences, 2018, 10.1051/medsci/20183402011
  • A new twist in the microRNA pathway: Not dicer but argonaute is required for a microRNA production, Simard, M.J., Bossé, G.D., Cell Research, 2010, 10.1038/cr.2010.83
  • Interaction between a J-domain co-chaperone and a specific Argonaute protein contributes to microRNA function in animals, Martin J Simard, Isabelle Banville, Guillaume Jannot, Pierre-Marc Frédérick, Nucleic Acids Research, 2024, 10.1093/nar/gkae272
  • CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma, Martin J. Simard, Fátima Gebauer, Lucie Germain, Benjamin Goyer, Louis-Mathieu Harvey, Francois Houle, Tanit Guitart, Pavan Kumar Kakumani, Oncogene, 2021, 10.1038/s41388-021-01767-9
  • Casein kinase 1 and 2 phosphorylate Argonaute proteins to regulate miRNA‐mediated gene silencing, Martin J Simard, Gunter Meister, Astrid Bruckmann, Daniela M Zeitler, Miguel Quévillon Huberdeau, Julia Neumeier, Vivek Nilesh Shah, EMBO reports, 2023, 10.15252/embr.202357250
  • Structural biology: Tracing Argonaute binding, Simard, M.J., Bouasker, S., Nature, 2009, 10.1038/461743a
  • MicroRNA-19a enhances proliferation of bronchial epithelial cells by targeting TGFβR2 gene in severe asthma, Chakir, J., Bossé, Y., Simard, M.J., Plante, S., Jacques, E., Bérubé, J.-C., Fakhfakh, R., Haj-Salem, I., Allergy: European Journal of Allergy and Clinical Immunology, 2015, 10.1111/all.12551
  • Next-generation biobanking of metastases to enable multidimensional molecular profiling in personalized medicine, Batist, G., Têtu, B., Spatz, A., Rousseau, C., Qureshi, S., Przybytkowrski, E., Buchanan, M., Chabot, C., Lan, C., Dalfen, R., Alcindor, T., Kavan, P., Samson, B., Lespérance, B., Gagnon-Kugler, T., Klinck, R., Gologan, A., Chabot, B., Simard, M.J., Jannot, G., Bachvarov, D., Benlimame, N., Constantin, A., Camlioglu, E., Orain, M., Basik, M., Paquet, E.R., Aguilar-Mahecha, A., Diaz, Z., Modern Pathology, 2013, 10.1038/modpathol.2013.81
  • Developmental characterization of the microRNA-specific C. elegans argonautes alg-1 and alg-2, Simard, M.J., Miska, E.A., Rondeau, E.L., Bukhari, S.I.A., Labouesse, M., Armisen, J., Jannot, G., Vasquez-Rifo, A., PLoS ONE, 2012, 10.1371/journal.pone.0033750
  • The microRNA pathway controls germ cell proliferation and differentiation in C. elegans, Simard, M.J., Masson, J.-Y., Robert, C., Zetka, M., Paquet, E.R., Gagné, D., Vasquez-Rifo, A., Bukhari, S.I.A., Cell Research, 2012, 10.1038/cr.2012.31
  • Polypyrimidine tract binding protein (hnRNP I) is possibly a conserved modulator of miRNA-mediated gene regulation, Hutvagner, G., Simard, M.J., Remenyi, J., Jannot, G., Engels, B., PLoS ONE, 2012, 10.1371/journal.pone.0033144
  • Control of hnRNP A1 alternative splicing: An intron element represses use of the common 3' splice site, Chabot, B., Simard, M.J., Molecular and Cellular Biology, 2000, 10.1128/MCB.20.19.7353-7362.2000
  • The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans, Simard, M.J., Hutvagner, G., Piquet, S., Banville, I.H., Bouasker, S., Giguère, N.J., Bajan, S., Jannot, G., EMBO Reports, 2011, 10.1038/embor.2011.66
  • The R148.3 gene modulates Caenorhabditis elegans lifespan and fat metabolism, Picard, F., Taubert, S., Simard, M.J., Guillemette, C., Rondeau, É., Lee, K., Miard, S., Grants, J.M., Roy-Bellavance, C., G3: Genes, Genomes, Genetics, 2017, 10.1534/g3.117.041681
  • Argonaute pull-down and RISC analysis using 2'-O-methylated oligonucleotides affinity matrices., Simard, M.J., Vasquez-Rifo, A., Jannot, G., Methods in molecular biology (Clifton, N.J.), 2011
  • Kinetics of eosinophilia and eosinophil activation in the development of non-allergic bronchial hyperresponsiveness in guinea pigs injected with Sephadex beads, Sirois, P., Arseneault, D., Simard, M.J., Maghni, K., Inflammation, 1996, 10.1007/BF01487044
  • p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells, Martin J. Simard, Jacques Huot, Liang Zhong, Scientific Reports, 2018, 10.1038/s41598-018-20837-9
  • Defining the contribution of microRNA-specific slicing Argonautes in animals, Martin J. Simard, Allison L. Abbott, Katherine A. Maniates, Miguel Quévillon Huberdeau, François Houle, Michael Lantin, Vaishnav Vasudevan, Anisha Pal, 2023, 10.1101/2023.01.19.524781
  • A member of the polymerase β nucleotidyltransferase superfamily is required for RNA interference in C. elegans, Mello, C.C., McCollough, J.A., Brownell, D.R., Tabara, H., Simard, M.J., Chen, C.-C.G., Current Biology, 2005, 10.1016/j.cub.2005.01.009
  • Human let-7a miRNA blocks protein production on actively translating polyribosomes, Richter, J.D., Simard, M.J., Nottrott, S., Nature Structural and Molecular Biology, 2006, 10.1038/nsmb1173
  • The implication of microRNAs and endo-siRNAs in animal germline and early development, Simard, M.J., Dallaire, A., Developmental Biology, 2016, 10.1016/j.ydbio.2016.06.007
  • Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans, Duchaine, T.F., Wohlschlegel, J., Simard, M.J., Keiper, B.D., Jannot, G., Vashisht, A., Wu, E., Flamand, M.N., Nucleic Acids Research, 2016, 10.1093/nar/gkw276
  • Mutations in Conserved Residues of the C. elegans microRNA Argonaute ALG-1 Identify Separable Functions in ALG-1 miRISC Loading and Target Repression, Ambros, V., Hammell, C.M., Simard, M.J., Bouasker, S., Zinovyeva, A.Y., PLoS Genetics, 2014, 10.1371/journal.pgen.1004286
  • Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi, Mello, C.C., Simard, M.J., Mitani, S., Joshua-Tor, L., Tolia, N.H., Chen, C.-C.G., Pang, K.M., Bei, Y., Batista, P.J., Yigit, E., Cell, 2006, 10.1016/j.cell.2006.09.033
  • An element in the 5' common exon of the NCAM alternative splicing unit interacts with SR proteins and modulates 5' splice site selection, Chabot, B., Simard, M.J., Côté, J., Nucleic Acids Research, 1999, 10.1093/nar/27.12.2529
  • CSDE1 controls gene expression through the miRNA-mediated decay machinery, Martin J Simard, Fátima Gebauer, Tanit Guitart, François Houle, Louis-Mathieu Harvey, Pavan Kumar Kakumani, Life Science Alliance, 2020, 10.26508/lsa.201900632
  • The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans, Martin J. Simard, Rachid Mazroui, Weifeng Gu, Camille Lavoie-Ouellet, Rachel Rioux, Miguel Quévillon Huberdeau, Francois Houle, Pauline Adjibade, Vivek Nilesh Shah, Pascale Michaud, PLOS Genetics, 2021, 10.1371/journal.pgen.1009511
  • Interaction between a J-domain co-chaperone and a specific Argonaute protein contributes to microRNA function in animals, Martin J. Simard, Isabelle Banville, Guillaume Jannot, Pierre-Marc Frédérick, 2024, 10.1101/2024.02.27.581607
  • Two molecular features contribute to the Argonaute specificity for the microRNA and RNAi pathways in C. elegans, Simard, M.J., Banville, I.H., Boisvert, M.-E.L., Jannot, G., RNA, 2008, 10.1261/rna.901908
  • RIP-chip-SRM - A new combinatorial large-scale approach identifies a set of translationally regulated bantam/miR-58 targets in C. elegans, Hengartner, M.O., Gerber, A.P., Aebersold, R., Miska, E.A., Simard, M.J., Wollscheid, B., Kaufman, E., Neukomm, L.J., Frei, A., Rehrauer, H., Picotti, P., Weiss, M., Reiter, L., Clark, A., Jovanovic, M., Genome Research, 2012, 10.1101/gr.133330.111
  • P38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription, Simard, M.J., Huot, J., Simoneau, B., Zhong, L., Oncotarget, 2017, 10.18632/oncotarget.13779
  • RNAi pathway in C. elegans: The argonautes and collaborators, Simard, M.J., Boisvert, M.-E.L., Current Topics in Microbiology and Immunology, 2008, 10.1007/978-3-540-75157-1_2

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/04
  • Vaishnav Vasudevan - Doctorat - En cours
  • Louis-Mathieu Harvey - Doctorat - En cours
  • Mathieu William Segonds - Doctorat - En cours
  • Mickael Lhuillier - Maîtrise avec mémoire - En cours
  • Pascale Michaud - Doctorat - 2020/09
  • Pierre-Marc Frédérick - Maîtrise avec mémoire - 2020/09
  • Michael Lantin - Maîtrise avec mémoire - 2022/05
  • Vincent Roy - Maîtrise avec mémoire - 2022/09
  • Vivek Nilesh Shah - Doctorat - 2024/01
  • Anisha Pal - Doctorat - 2024/05

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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