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Michaël Shum
Professeur sous octroi adjoint
Contribution à la recherche
Projets de recherche
- Fonds de démarrage pour chercheurs en debut de carrière – Bourse de recrutement étudiant - Université Laval - Fonds internes - Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, chercheur principal - 2023-07-01 au 2028-06-30
- L'hétérogénéité mitochondriale et sa reprogrammation dans les maladies métaboliques. - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2023-07-01 au 2027-06-30
- L'hétérogénéité mitochondriale et sa reprogrammation dans les maladies métaboliques - Subvention établissement de jeune chercheur - Fonds de recherche du Québec - Santé - Établissement de jeunes chercheurs - Juniors 1, chercheur principal - 2023-04-01 au 2027-03-31
- Diabetes and Healthy Liver- Unravelling the links between postprandial metabolism in type 2 diabetes and progression of metabolic fatty liver disease - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2022-04-01 au 2027-03-31
- Understanding mitochondria and lipids droplet interactions in cell biology - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2021-04-01 au 2026-03-31
- Mitochondria bound to lipid droplets as new regulators of insulin resistance - Diabète Canada - Subvention de fonctionnement : Mettre fin au diabète prix 2022, chercheur principal - 2022-12-01 au 2025-11-30
- Rôle de la bilirubine endogène dans l’inflammation et la résistance à l’insuline - Diabète Québec - Subventions pour la recherche, chercheur principal - 2023-04-01 au 2024-03-31
- Fonds de démarrage, Michael Shum - CHU de Québec – Université Laval – CHUL, Fondation du CHU de Québec - Fonds de démarrage, chercheur principal - 2021-01-11 au 2024-01-10
- The mTORC1/2 and DEPTOR pathway regulates a novel prolipogenic mitochondrial population in obese mice - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, chercheur principal - 2022-04-01 au 2023-03-31
- Caractérisation du protéome mitochondrial de la prostate - CHU de Québec – Université Laval – CHUL - Subvention de fonctionnement de centre, co-chercheur - 2022-09-21 au 2023-03-31
- ABCB10 reprograms mitochondria in pro-inflammatory macrophages of obese mice - CHU de Québec – Université Laval – CHUL - Subvention de fonctionnement de centre, chercheur principal - 2022-09-21 au 2023-03-31
Publications
- Sex-specific metabolic functions of adipose Lipocalin-2, Lusis, A.J., Liesa, M., Reue, K., Péterfy, M., Stiles, L., Pan, C., Anum, D.C., Nand, S.K., Jayasekera, D.W., Fuqua, B.K., Seldin, M.M., Vergnes, L., Floyd, R.R., Lang, J.M., Acín-Pérez, R., Meng, Y., Shum, M., Sabir, S., Chella Krishnan, K., Molecular Metabolism, 2019, 10.1016/j.molmet.2019.09.009
- Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion, Shirihai, O.S., Liesa, M., Corkey, B.E., Wohlschlegel, J.A., Barshop, W.D., Sztalryd, C., Cinti, S., Oliveira, M.F., Shum, M., Acín-Pérez, R., Assali, E.A., Wikstrom, J.D., Petcherski, A., Mahdaviani, K., Veliova, M., Benador, I.Y., Cell Metabolism, 2018, 10.1016/j.cmet.2018.03.003
- Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance, Marc Liesa, Orian S. Shirihai, Maike Sander, Vincent Gutierrez, Zhiqiang Zhou, Linsey Stiles, Laura Nocito, Samuel B. Sereda, Dane M. Wolf, Siyouneh Baghdasarian, Matthew Wortham, Ana Viñuela, Raffi Gharakhanian, Mayuko Segawa, Michael Shum, Molecular Metabolism, 2022, 10.1016/j.molmet.2021.101403
- Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice, Correa, S.M., Adhikari, A., Xu, Y., Ajijola, O.A., Liesa, M., Paul, K., Anderson, S., Massa, M.G., Nichols, I., Shum, M., Maesta-Pereira, S., van Veen, J.E., Sivakumar, N., DiVittorio, J.R., Park, J.W., He, Y., Reis, F.M.C.V., Zhang, Z., Nature Communications, 2020, 10.1038/s41467-020-20050-1
- Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure, Correa, S.M., Yang, X., Arnold, A.P., Liesa, M., Hrncir, H., Joseph, A.M., Zhang, Z., Park, J.W., Arneson, D.V., Massa, M.G., Reid, M.S., Shum, M., Kammel, L.G., Bunda, P.C., van Veen, J.E., Nature Metabolism, 2020, 10.1038/s42255-020-0189-6
- Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice, , Journal of Visualized Experiments, 2021, 10.3791/63066
- Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: Potential role of PPARγ, Marette, A., Beauchemin, N., Neel, B.G., Siminovitch, K.A., Lévy, E., Montoudis, A., Paquet, M., Voisin, G., Shum, M., Bellmann, K., Caron, A.Z., St-Amand, E., Avramoglu, R.K., Schwab, M., Forest, M.-P., Xu, E., Hepatology, 2014, 10.1002/hep.26957
- Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice, Marette, A., St-Pierre, P., Bellmann, K., Shum, M., Diabetologia, 2016, 10.1007/s00125-015-3839-6
- ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity, Marc Liesa, Elisabeth P. Carpenter, Maria E. Zoghbi, Andrea L. Hevener, Aldons J. Lusis, Jeff Abramson, Linsey Stiles, Laura Nocito, Jennifer Ngo, Dane M. Wolf, Michaela Veliova, Kiana Mahdaviani, Karthickeyan Chella Krishnan, Shi Su, Raffi Gharakhanian, Belinda Faust, Margaret R. Young, Roslin Adamson, Melissa Martinez, Alexandra D. Saxberg, Mayuko Segawa, Vincent Gutierrez, Thorsten Althoff, Chitra A. Shintre, Michael Shum, Science Translational Medicine, 2021, 10.1126/scitranslmed.abd1869
- AMPK in skeletal muscle function and metabolism, Lantier, L., Viollet, B., Wojtaszewski, J.F.P., Treebak, J.T., Mounier, R., Marette, A., Shum, M., Pehmøller, C., Sanz, M.-N., Foretz, M., Fentz, J., Hingst, J.R., Kjøbsted, R., FASEB Journal, 2018, 10.1096/fj.201700442R
- AT2 Receptor Agonists: Exploiting the Beneficial Arm of Ang II Signaling, , Current Hypertension Reviews, 2012
- AT2 receptor agonists: Exploiting the beneficial Arm of Ang II signaling, Carpentier, A.C., Hallberg, A., Alterman, M., Wallinder, C., Langlois, M.-F., Baillargeon, J.-P., Shum, M., Gallo-Payet, N., Current Hypertension Reviews, 2012, 10.2174/157340212800504990
- NCLX prevents cell death during adrenergic activation of the brown adipose tissue, Shirihai, O.S., Sekler, I., Liesa, M., Las, G., Oliveira, M.F., Shum, M., Miller, N., Taha, M., Acín-Pérez, R., Veliova, M., Jones, A.E., Assali, E.A., Nature Communications, 2020, 10.1038/s41467-020-16572-3
- Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2, Aldons J. Lusis, Marc Liesa, Markku Laakso, Johan L. M. Björkegren, Karen Reue, Casey E. Romanoski, Miklós Péterfy, Timothy M. Moore, Calvin Pan, Etienne Mouisel, Lijiang Ma, Michael Shum, Linsey Stiles, Rebeca Acín-Pérez, Laurent Vergnes, Karthickeyan Chella Krishnan, Nature Metabolism, 2021, 10.1038/s42255-021-00481-w
- Angiotensin II type 2 receptor promotes adipocyte differentiation and restores adipocyte size in high-fat/high-fructose diet-induced insulin resistance in rats, Gallo-Payet, N., Carpentier, A.C., Hallberg, A., Wallinder, C., Alterman, M., Langlois, M.-F., Baillargeon, J.-P., Roberge, C., Labbé, S.M., Guimond, M.-O., Pinard, S., Shum, M., American Journal of Physiology - Endocrinology and Metabolism, 2013, 10.1152/ajpendo.00149.2012
- Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells, Marette, A., Foretz, M., Viollet, B., St-Pierre, P., Bellmann, K., Moreira, R.J., Bellemare, V., Houde, V.P., Shum, M., Journal of Biological Chemistry, 2019, 10.1074/jbc.RA119.008488
- Loss of hepatic DEPTOR alters the metabolic transition to fasting, Laplante, M., Sabatini, D.M., Richard, D., Marette, A., Gélinas, Y., Shum, M., Lamoureux, G., Secco, B., Turcotte, L., Villot, R., Labbé, S.M., Gautier, N., Mouchiroud, M., Caron, A., Molecular Metabolism, 2017, 10.1016/j.molmet.2017.02.005
- Postprandial fatty acid uptake and adipocyte remodeling in angiotensin type 2 receptor-deficient mice fed a high-fat/high-fructose diet, Gallo-Payet, N., Carpentier, A.C., Lecomte, R., Phoenix, S., Chouinard, L., Bilodeau, L., Shum, M., Pinard, S., Labbé, S.M., Noll, C., Adipocyte, 2016, 10.1080/21623945.2015.1115582
- Mitochondrial oxidative function in NAFLD: Friend or foe?, Liesa, M., Shirihai, O.S., Ngo, J., Shum, M., Molecular Metabolism, 2020, 10.1016/j.molmet.2020.101134
- Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism, Marette, A., Abe, J.-I., Roux, P.P., Déléris, P., Shum, M., Smadja-Lamère, N., Journal of Biological Chemistry, 2013, 10.1074/jbc.M113.474148
Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Thomas Belmas - Doctorat - En cours
- Maxence Brouillette - Maîtrise avec mémoire - En cours
- Heitor Cappato Guerra Silva - Doctorat - En cours
- Thomas Guerbette - Post-doctorat - En cours