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Patrice Brassard

Professeur titulaire

Patrice.Brassard@kin.ulaval.ca
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec
Centre de recherche de l'IUCPQ
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Santé circulatoire et respiratoire
  • Système cardiovasculaire
  • Maladies cardiovasculaires
  • Hypertension artérielle
  • Circulation et transfusion sanguine
Organismes vivants (êtres humains - Psychologie/aspects biologiques)

Projets de recherche

  • Cerebral blood flow regulation during acute increases in blood pressure: Can cerebral sympathetic nervous activity act as a gatekeeper? - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2020-04-01 au 2025-03-31
  • Séquenceur de gaz et moniteur non-invasif de pression artérielle pour la recherche et l'innovation en physiologie vasculaire cérébrale - Ministère de la Santé et des Services sociaux, Fondation Canadienne pour l'innovation (La), Fondation IUCPQ - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2022-07-01 au 2024-12-31
  • Comparing the effects of cognitive training and physical exercise on cognition, cerebral autoregulation and cerebral vasoreactivity in men and women with heart failure - Instituts de recherche en santé du Canada - Subvention Projet, Université Concordia, co-chercheur - 2019-04-01 au 2023-03-31

Publications

  • Regarding "The Effects of an Exercise and Lifestyle Intervention Program on Cardiovascular, Metabolic Factors and Cognitive Performance in Middle-Aged Adults with Type 2 Diabetes: A Pilot Study. Can J Diabetes 2013;37:214-9", Brassard, P., Paquette, M., Canadian Journal of Diabetes, 2014, 10.1016/j.jcjd.2013.12.004
  • Prevalence of risk factors for cardiovascular disease in paramedics, Corbeil, P., Tremblay, A., Poirier, P., Jauvin, N., Larouche, D., Prairie, J., Brassard, P., Hegg-Deloye, S., International Archives of Occupational and Environmental Health, 2015, 10.1007/s00420-015-1028-z
  • High-intensity interval exercise and cerebrovascular health: Curiosity, cause, and consequence, Bailey, D.M., Brassard, P., Cotter, J.D., Lucas, S.J.E., Journal of Cerebral Blood Flow and Metabolism, 2015, 10.1038/jcbfm.2015.49
  • Directional sensitivity of the cerebral pressure-flow relationship during forced oscillations induced by oscillatory lower body negative pressure, Brassard, P., Smirl, J.D., Taghizadeh, M., Soleimani Dehnavi, S., Roy, M.-A., Labrecque, L., Journal of Cerebral Blood Flow and Metabolism, 2024, 10.1177/0271678X241247633
  • Exercise Intolerance in Heart Failure: Did We Forget the Brain?, Gustafsson, F., Brassard, P., Canadian Journal of Cardiology, 2016, 10.1016/j.cjca.2015.12.021
  • Targeting optimal blood pressure monitoring: What’s next?, Halwagi, A.E., Jacquet-Lagrèze, M., Brassard, P., Denault, A.Y., Journal of Thoracic Disease, 2018, 10.21037/jtd.2018.08.115
  • Lower Dynamic Cerebral Autoregulation following Acute Bout of Low-Volume High-Intensity Interval Exercise in Chronic Stroke Compared to Healthy Adults, Billinger, S.A., Eickmeyer, S.M., Waghmare, S., Vidoni, E.D., Nguyen, K., Buchanan, J., Brassard, P., Chertoff, M., Aaron, S.E., Whitaker, A.A., medRxiv, 2023, 10.1101/2023.06.13.23291289
  • On the challenge of assessing dynamic cerebral autoregulation, Smirl, J.D., Labrecque, L., Roy, M.-A., Brassard, P., Experimental Physiology, 2024, 10.1113/EP091703
  • Continuous reduction in cerebral oxygenation during endurance exercise in patients with pulmonary arterial hypertension, Provencher, S., Bonnet, S., Chouinard, A., Le Blanc, O., Paquette, M., Brassard, P., Malenfant, S., Physiological Reports, 2020, 10.14814/phy2.14389
  • Cardiac remodeling after six weeks of high-intensity interval training to exhaustion in endurance-trained males, Brassard, P., Pibarot, P., Bédard, É., Poirier, P., Drapeau, A., Labrecque, L., Imhoff, S., Paquette, M., Le Blanc, O., Mahjoub, H., bioRxiv, 2019, 10.1101/582924
  • The role of the autonomic nervous system in cerebral blood flow regulation in dementia: A review, Panerai, R.B., Haunton, V., Robinson, T.G., Minhas, J.S., Brassard, P., Gurung, D., Hosford, P., Beishon, L.C., Autonomic Neuroscience: Basic and Clinical, 2022, 10.1016/j.autneu.2022.102985
  • Transfer function analysis of dynamic cerebral autoregulation: A CARNet white paper 2022 update, Simpson, D.M., Smirl, J.D., Rodrigues, G.D., Robertson, A.D., Rickards, C.A., Payne, S.J., Ogoh, S., Nogueira, R.C., Mitsis, G.D., Minhas, J.S., Lucas, S.J.E., Liu, J., van Lieshout, J.J., Claassen, J.A.H.R., Castro, P., Burma, J.S., Brassard, P., Panerai, R.B., Journal of Cerebral Blood Flow and Metabolism, 2023, 10.1177/0271678X221119760
  • Is cerebral oxygenation negatively affected by infusion of norepinephrine in healthy subjects?, Secher, N.H., Seifert, T., Brassard, P., British Journal of Anaesthesia, 2009, 10.1093/bja/aep065
  • Maternal and Fetal Cardiovascular Responses to Acute High-Intensity Interval and Moderate-Intensity Continuous Training Exercise During Pregnancy: A Randomized Crossover Trial, Davenport, M.H., Brassard, P., Labrecque, L., Berg, E.R.V., Hazell, T.J., Wowdzia, J.B., Sports Medicine, 2023, 10.1007/s40279-023-01858-5
  • Sex-specific effects of cardiorespiratory fitness on age-related differences in cerebral hemodynamics, Barnes, J.N., Billinger, S.A., Brassard, P., Aaron, S.E., Labrecque, L., Howery, A.J., Zea, R.D., Miller, K.B., Zeller, N.P., Journal of Applied Physiology, 2022, 10.1152/japplphysiol.00782.2021
  • Is hypotension or tissue oxygenation responsible for morbidity and mortality after cardiopulmonary bypass?, Brassard, P., Journal of Thoracic and Cardiovascular Surgery, 2014, 10.1016/j.jtcvs.2013.10.075
  • Current state of knowledge of post-traumatic stress, sleeping problems, obesity and cardiovascular disease in paramedics, Corbeil, P., Tremblay, A., Poirier, P., Larouche, D., Prairie, J., Jauvin, N., Brassard, P., Hegg-Deloye, S., Emergency Medicine Journal, 2014, 10.1136/emermed-2012-201672
  • Evidence for hysteresis in the cerebral pressure-flow relationship in healthy men, Ainslie, P.N., Malenfant, S., Blanc, O.L., Paquette, M., Smirl, J.D., Ferland-Dutil, H., Brassard, P., American Journal of Physiology - Heart and Circulatory Physiology, 2017, 10.1152/ajpheart.00790.2016
  • Determinants of Improvement in Left Ventricular Diastolic Function Following a 1-Year Lifestyle Modification Program in Abdominally Obese Men with Features of the Metabolic Syndrome, Poirier, P., Denault-Bissonnette, S., Ross, M.-K., Auclair, A., Tremblay, A., Alméras, N., Bergeron, J., Gaudreault, V., Brassard, P., Després, J.-P., Arsenault, M., Leclerc, J., Metabolic Syndrome and Related Disorders, 2016, 10.1089/met.2016.0021
  • Uncoupling between cerebral perfusion and oxygenation during incremental exercise in an athlete with postconcussion syndrome: a case report, Brassard, P., Bailey, D.M., Poirier, P., Nadreau, É., Malenfant, S., Imhoff, S., Physiological Reports, 2017, 10.14814/phy2.13131
  • Time-course recovery of cerebral blood velocity metrics post aerobic exercise: a systematic review, Smirl, J.D., Brassard, P., Newel, K.T., Burma, J.S., Kennedy, C.M., Journal of Applied Physiology, 2022, 10.1152/japplphysiol.00630.2021
  • A Practical Approach to Cerebro-Somatic Near-Infrared Spectroscopy and Whole-Body Ultrasound, Deschamps, A., Lamarche, Y., Jacquet-Lagrèze, M., Mailhot, T., Brassard, P., Bouabdallaoui, N., Beaubien-Souligny, W., Couture, E.J., Shaaban Ali, M., Denault, A., Journal of Cardiothoracic and Vascular Anesthesia, 2019, 10.1053/j.jvca.2019.03.039
  • Directional sensitivity of the cerebral pressure-flow relationship in middle and posterior cerebral arteries using the repeated squat-stand model: Within-day reproducibility and impact of diurnal variation in young healthy men and women, Brassard, P., Smirl, J.D., Roy, M.-A., Burma, J.S., Labrecque, L., bioRxiv, 2021, 10.1101/2021.07.30.454396
  • Exercise capacity and impact of exercise training in patients after a Fontan procedure: A review, Poirier, P., Rodés-Cabau, J., Jobin, J., Bédard, É., Brassard, P., Canadian Journal of Cardiology, 2006, 10.1016/S0828-282X(06)70266-5
  • Effects of submaximal and supramaximal interval training on determinants of endurance performance in endurance athletes, Brassard, P., Bailey, D.M., Thibault, G., Lucas, S.J.E., Le Blanc, O., Paquette, M., Scandinavian Journal of Medicine and Science in Sports, 2017, 10.1111/sms.12660
  • Cerebral non-oxidative carbohydrate consumption in humans driven by adrenaline, Nielsen, H.B., Secher, N.H., Quistorff, B., Rasmussen, P., Hamada, A.J., Jørgensen, T.B., Brassard, P., Seifert, T.S., Journal of Physiology, 2009, 10.1113/jphysiol.2008.162073
  • Dysfonction diastolique ventriculaire gauche, Lévesque, A., Brassard, P., Leclerc, J., Perspective infirmiere : revue officielle de l'Ordre des infirmieres et infirmiers du Quebec, 2018
  • Sympathetic control of the brain circulation: Appreciating the complexities to better understand the controversy, Ainslie, P.N., Tymko, M.M., Brassard, P., Autonomic Neuroscience: Basic and Clinical, 2017, 10.1016/j.autneu.2017.05.003
  • Evidence for a release of brain-derived neurotrophic factor from the brain during exercise, Pilegaard, H., Pedersen, B.K., Secher, N.H., Hart, E., Leick, L., Pedersen, M.V., Adser, H., Brassard, P., Rasmussen, P., Experimental Physiology, 2009, 10.1113/expphysiol.2009.048512
  • Habitual exercise in youth: A ʻbrainyʼ idea, Brassard, P., Baynard, T., Barnes, J.N., Experimental Physiology, 2023, 10.1113/EP091534
  • Trans-cerebral HCO3− and PCO2 exchange during acute respiratory acidosis and exercise-induced metabolic acidosis in humans, Ainslie, P.N., MacLeod, D.B., Sekhon, M.S., Drapeau, A., Bailey, D.M., Stacey, B.S., Carr, J.M.J.R., Howe, C.A., Tymko, M.M., Bain, A.R., Brassard, P., Smith, K.J., Hoiland, R.L., Caldwell, H.G., Journal of Cerebral Blood Flow and Metabolism, 2022, 10.1177/0271678X211065924
  • Impact of diabetes, chronic heart failure, congenital heart disease and chronic obstructive pulmonary disease on acute and chronic exercise responses, Poirier, P., Jobin, J., Maltais, F., Marquis, K., Ferland, A., Brassard, P., Canadian Journal of Cardiology, 2007, 10.1016/s0828-282x(07)71018-8
  • Hemodynamic stress echocardiography in patients supported with a continuous-flow left ventricular assist device, Møller, J.E., Nordsborg, N., Hassager, C., Secher, N., Jensen, A.S., Brassard, P., Madsen, P.L., Gustafsson, F., Andersen, M., JACC: Cardiovascular Imaging, 2010, 10.1016/j.jcmg.2010.06.007
  • Individual Patient Data Meta-Analysis of Dynamic Cerebral Autoregulation and Functional Outcome after Ischemic Stroke, Nogueira, R.C., Panerai, R.B., Robinson, T.G., Simpson, D., Robertson, A.D., Payne, S., Nasr, N., Mueller, M., Liu, J., Jara, J.L., Gommer, E.D., Goettel, N., Brassard, P., Castro, P., Minhas, J.S., Gkargkoula, P., Ramesh, P., Hills, E., Barnes, S., Levis, B., Salinet, A.S.M., Vasilopoulos, T., Beishon, L., Stroke, 2024, 10.1161/STROKEAHA.123.045700
  • Early Detection and Correction of Cerebral Desaturation with Noninvasive Oxy-Hemoglobin, Deoxy-Hemoglobin, and Total Hemoglobin in Cardiac Surgery: A Case Series, Denault, A.Y., Deschamps, A., Courbe, A., Martins, M.R., Ayoub, C., Lebon, J.-S., Rochon, A., Matta, B., Shaaban-Ali, M., Lamarche, Y., Liszkowski, M., Momeni, M., Beaubien-Souligny, W., Brassard, P., Couture, E.J., Jarry, S., Calderone, A., Anesthesia and Analgesia, 2022, 10.1213/ANE.0000000000006155
  • What recording duration is required to provide physiologically valid and reliable dynamic cerebral autoregulation transfer functional analysis estimates?, Smirl, J.D., Macaulay, A., Copeland, P., Brassard, P., Drapeau, A., Labrecque, L., Newel, K.T., Miutz, L.N., Burma, J.S., Physiological Measurement, 2021, 10.1088/1361-6579/abf1af
  • Transfer function analysis of dynamic cerebral autoregulation: A white paper from the International Cerebral Autoregulation Research Network, Novak, V., Marmarelis, V., Zhang, R., Serrador, J., Rickards, C.A., Shin, D., Puppo, C., Yelicich, B., Bailey, D., Payne, S., Czosnyka, M., Liu, X., Smielewski, P., Potter, J., Aliev, V., Semenyuti, V., Van Lieshout, J.J., Aries, M., Karemaker, J.M., Gommer, E., Meel-Van Den Abeelen, A.S.S., Hu, H.H., Wang, C.-Y., Müller, M., Tzeng, Y.-C., Ragauskas, A., Iwasaki, K., Summers, P., Ainslie, P.N., Brassard, P., Mitsis, G.D., Alexander Caicedo Dorado, Panerai, R.B., Simpson, D.M., Meel-Van Den Abeelen, A.S., Claassen, J.A., Journal of Cerebral Blood Flow and Metabolism, 2015, 10.1177/0271678X15626425
  • Lower dynamic cerebral autoregulation following acute bout of low-volume high-intensity interval exercise in chronic stroke compared to healthy adults, Billinger, S.A., Montgomery, R.N., Eickmeyer, S.M., Waghmare, S., Vidoni, E.D., Nguyen, K., Buchanan, J., Brassard, P., Chertoff, M., Aaron, S.E., Whitaker, A.A., Journal of Applied Physiology, 2024, 10.1152/japplphysiol.00635.2023
  • Dynamic cerebral autoregulation is attenuated in young fit women, Brassard, P., Bailey, D.M., Smirl, J.D., Drapeau, A., Malenfant, S., Le Blanc, O., Paquette, M., Imhoff, S., Rahimaly, K., Labrecque, L., Physiological Reports, 2019, 10.14814/phy2.13984
  • Impact of bariatric surgery-induced weight loss on heart rate variability, Poirier, P., Richard, D., Lebel, S., Hould, F., Biron, S., Marceau, S., Marceau, P., Brassard, P., Paquet, C., Nadreau, E., Nault, I., Metabolism: Clinical and Experimental, 2007, 10.1016/j.metabol.2007.06.006
  • Diabetes and exercise-induced hemodynamic responses, Poirier, P., Brassard, P., Diabetes Research and Clinical Practice, 2007, 10.1016/j.diabres.2007.03.003
  • Near Infrared Spectroscopy for Poor Grade Aneurysmal Subarachnoid Hemorrhage—A Concise Review, Turgeon, A.F., Brassard, P., Lauzier, F., Francoeur, C.L., Frontiers in Neurology, 2022, 10.3389/fneur.2022.874393
  • Sympathetic activity and cerebral oxygenation, Secher, N.H., Seifert, T., Brassard, P., Moppett, I.K., British Journal of Anaesthesia, 2009, 10.1093/bja/aep281
  • Quantification of dynamic cerebral autoregulation: welcome to the jungle!, Smirl, J.D., Labrecque, L., Burma, J.S., Roy, M.-A., Brassard, P., Clinical Autonomic Research, 2023, 10.1007/s10286-023-00986-2
  • Why is the neural control of cerebral autoregulation so controversial, Brassard, P., Ainslie, P.N., F1000Prime Reports, 2014, 10.12703/P6-14
  • Utilization of the repeated squat-stand model for studying the directional behavior of the cerebral pressure-flow relationship, Brassard, P., Smirl, J.D., Labrecque, L., bioRxiv, 2020, 10.1101/2020.12.15.422722
  • Cerebral vs. Cardiovascular Responses to Exercise in Type 2 Diabetic Patients, van Lieshout, J.J., Secher, N.H., Brassard, P., van der Ster, B.J.P., Kim, Y.-S., Frontiers in Physiology, 2021, 10.3389/fphys.2020.583155
  • Phenylephrine decreases frontal lobe oxygenation at rest but not during moderately intense exercise, Secher, N.H., Hansen, C.K., Jensen, P.M., Wissenberg, M., Seifert, T., Brassard, P., Journal of Applied Physiology, 2010, 10.1152/japplphysiol.01206.2009
  • Six weeks of high-intensity interval training to exhaustion attenuates dynamic cerebral autoregulation without influencing resting cerebral blood velocity in young fit men, Brassard, P., Malenfant, S., Le Blanc, O., Paquette, M., Imhoff, S., Labrecque, L., Drapeau, A., Physiological Reports, 2019, 10.14814/phy2.14185
  • Impact of visceral obesity on cardiac parasympathetic activity in type 2 diabetics after coronary artery bypass graft surgery, Brassard, P., Costerousse, O., Alméras, N., Bertrand, O., Després, J.-P., Poirier, P., Pelletier, C., Salamin, G., Obesity, 2013, 10.1002/oby.20089
  • HIITing the brain with exercise: mechanisms, consequences and practical recommendations, Bailey, D.M., Wisløff, U., Ainslie, P.N., Roig, M., Cotter, J.D., Lucas, S.J.E., Brassard, P., Marchi, N., Steggall, M., Marley, C.J., Ogoh, S., Calverley, T.A., Journal of Physiology, 2020, 10.1113/JP275021
  • Impaired cerebral blood flow and oxygenation during exercise in type 2 diabetic patients, van Lieshout, J.J., Secher, N.H., Nielsen, H.B., Vaag, A., Rasmussen, P., Brassard, P., Seifert, T., Kim, Y.-S., Physiological Reports, 2015, 10.14814/phy2.12430
  • Impact of β-blocker treatment and nutritional status on glycemic response during exercise in patients with type 2 diabetes, Poirier, P., Fournier, L., Lacroix, S., Bergeron, J., Lemieux, S., Croteau, S., Brassard, P., Ferland, A., Clinical and Investigative Medicine, 2007
  • Reproducibility and diurnal variation of the directional sensitivity of the cerebral pressure-flow relationship in men and women, Brassard, P., Smirl, J.D., Roy, M.-A., Burma, J.S., Labrecque, L., Journal of Applied Physiology, 2022, 10.1152/japplphysiol.00653.2021
  • Blood Pressure Measurement in Severely Obese Patients: Validation of the Forearm Approach in Different Arm Positions, Poirier, P., Cloutier, L., Grenier, A., Godbout, C., Brassard, P., Marceau, S., Hould, F.-S., Agharazii, M., Bussières, J., Leclerc, J., Auclair, A., Leblanc, M.-E., American Journal of Hypertension, 2019, 10.1093/ajh/hpy152
  • eComment: Pharmacological agents increasing arterial pressure via total peripheral vasoconstriction should be avoided for maintaining brain oxygenation during cardiac displacement in off-pump cardiac surgery, Brassard, P., Interactive Cardiovascular and Thoracic Surgery, 2011, 10.1510/icvts.2011.272047B
  • Cardiac remodeling after six weeks of high-intensity interval training to exhaustion in endurance-trained men, Brassard, P., Pibarot, P., Bédard, E., Poirier, P., Drapeau, A., Labrecque, L., Imhoff, S., Paquette, M., Le Blanc, O.L., Mahjoub, H., American Journal of Physiology - Heart and Circulatory Physiology, 2019, 10.1152/ajpheart.00196.2019
  • Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke, Tzeng, Y.-C., Nasr, N., Page, M., Rickards, C.A., Brassard, P., Nogueira, R.C., Fan, J.-L., Journal of Cerebral Blood Flow and Metabolism, 2022, 10.1177/0271678X211033732
  • Integrative cerebral blood flow regulation in ischemic stroke, Tzeng, Y.-C., Fisher, J.P., McBryde, F.D., Nasr, N., Nogueira, R.C., Rickards, C.A., Brassard, P., Fan, J.-L., Journal of Cerebral Blood Flow and Metabolism, 2022, 10.1177/0271678X211032029
  • Physical activity counteracts the influence of mental work on blood pressure in healthy children, Perusse-Lachance, E., Rattray, B., Brassard, P., Lapointe, T., Physiology and Behavior, 2016, 10.1016/j.physbeh.2016.05.048
  • Implications of habitual endurance and resistance exercise for dynamic cerebral autoregulation, Lucas, S.J.E., Le Blanc, O., Paquette, M., Brassard, P., Labrecque, L., Lark, S., Korad, S., Cotter, J.D., Perry, B.G., Experimental Physiology, 2019, 10.1113/EP087675
  • Elevated peak exercise systolic blood pressure is not associated with reduced exercise capacity in subjects with Type 2 diabetes, Poirier, P., Jobin, J., Bonneville, N., Gaudreault, V., Ferland, A., Brassard, P., Journal of Applied Physiology, 2006, 10.1152/japplphysiol.00260.2006
  • Is aspartame really safer in reducing the risk of hypoglycemia during exercise in patients with type 2 diabetes? [1], Poirier, P., Brassard, P., Ferland, A., Diabetes Care, 2007, 10.2337/dc06-1888
  • Point/counterpoint: We should take the direction of blood pressure change into consideration for dynamic cerebral autoregulation quantification, Brassard, P., Tzeng, Y.-C., Smirl, J.D., Labrecque, L., Journal of Cerebral Blood Flow and Metabolism, 2022, 10.1177/0271678X221104868
  • Compromised cerebrovascular regulation and cerebral oxygenation in pulmonary arterial hypertension, Provencher, S., Bonnet, S., Simard, S., Tzeng, Y.-C., Allan, P.D., Nadeau, V., Chouinard, A., Blanc, O.L., Paquette, M., Brassard, P., Malenfant, S., Journal of the American Heart Association, 2017, 10.1161/JAHA.117.006126
  • Is elevated PCWP during exercise sufficient to reduce exercise capacity in diabetics?, Poirier, P., Brassard, P., Medicine and Science in Sports and Exercise, 2009, 10.1249/MSS.0b013e3181af25d3
  • Time-domain methods for quantifying dynamic cerebral blood flow autoregulation: Review and recommendations. A white paper from the Cerebrovascular Research Network (CARNet), Mitsis, G.D., Panerai, R.B., Smirl, J., Simpson, D., Shin, D.C., Payne, S.J., Marmarelis, V.Z., Liu, J., Labrecque, L., Hu, K., Elting, J.-W., Czosnyka, M., Claassen, J.A.H.R., Chacon, M., Brassard, P., Bello-Robles, F., Kostoglou, K., Journal of Cerebral Blood Flow and Metabolism, 2024, 10.1177/0271678X241249276
  • Comparable blood velocity changes in middle and posterior cerebral arteries during and following acute high-intensity exercise in young fit women, Brassard, P., Billaut, F., Imhoff, S., Rahimaly, K., Drapeau, A., Labrecque, L., Physiological Reports, 2020, 10.14814/phy2.14430
  • Letter to the editor: On the need of considering cardiorespiratory fitness when examining the influence of sex on dynamic cerebral autoregulation, Brassard, P., Smirl, J.D., Labrecque, L., American Journal of Physiology - Heart and Circulatory Physiology, 2019, 10.1152/ajpheart.00152.2019
  • Impact of sex on the cerebrovascular response to incremental aerobic exercise in moderately trained endurance athletes, Brassard, P., Rahimaly, K., Billaut, F., Roy, M.-A., Imhoff, S., Labrecque, L., Drapeau, A., Chamoun, N., Journal of Applied Physiology, 2023, 10.1152/JAPPLPHYSIOL.00749.2022
  • A proposed algorithm for combining transcranial Doppler ultrasound monitoring with cerebral and somatic oximetry: a case report,Proposition d’un algorithme combinant le monitorage échographique par Doppler transcrânien à l’oxymétrie cérébrale et somatique : une présentation de cas, Denault, A.Y., Gebhard, C.E., Brassard, P., Beaubien-Souligny, W., Couture, E.J., Azzam, M.A., Canadian Journal of Anesthesia, 2021, 10.1007/s12630-020-01832-z
  • Impact of high-fat/low-carbohydrate, high-, low-glycaemic index or low-caloric meals on glucose regulation during aerobic exercise in Type 2 diabetes, Poirier, P., Simard, S., Bertrand, F., Bogaty, P., Bergeron, J., Lemieux, S., Brassard, P., Ferland, A., Diabetic Medicine, 2009, 10.1111/j.1464-5491.2009.02734.x
  • Endotoxemia reduces cerebral perfusion but enhances dynamic cerebrovascular autoregulation at reduced arterial carbon dioxide tension, Rosenmeier, J.B., Secher, N.H., Van Lieshout, J., Kim, Y.-S., Brassard, P., Critical Care Medicine, 2012, 10.1097/CCM.0b013e3182474ca7
  • Diminished dynamic cerebral autoregulatory capacity with forced oscillations in mean arterial pressure with elevated cardiorespiratory fitness, Brassard, P., Smirl, J.D., Bailey, D.M., Lucas, S.J.E., Malenfant, S., Le Blanc, O., Paquette, M., Imhoff, S., Rahimaly, K., Labrecque, L., bioRxiv, 2017, 10.1101/190405
  • Reply from Drs. Brassard and Poirier [9], Poirier, P., Brassard, P., Journal of Applied Physiology, 2006, 10.1152/japplphysiol.01041.2006
  • On the use and misuse of cerebral hemodynamics terminology using transcranial Doppler ultrasound: a call for standardization, Brassard, P., Smirl, J.D., Rickards, C.A., Day, T.A., Claassen, J.A.H.R., Brothers, R.M., Skow, R.J., American Journal of Physiology - Heart and Circulatory Physiology, 2022, 10.1152/ajpheart.00107.2022
  • Utilization of the repeated squat-stand model for studying the directional sensitivity of the cerebral pressure-flow relationship, Brassard, P., Smirl, J.D., Labrecque, L., Journal of Applied Physiology, 2021, 10.1152/japplphysiol.00269.2021
  • Impact of "noncaloric" activity-related factors on the predisposition to obesity in children, Brassard, P., Pérusse-Lachance, E., Tremblay, A., Risk Management and Healthcare Policy, 2010, 10.2147/rmhp.s7986
  • Comparison of the Buffalo Concussion Treadmill Test With a Physiologically Informed Cycle Test: Calgary Concussion Cycle Test, Smirl, J.D., Emery, C.A., Phillips, A.A., Brassard, P., Burma, J.S., Miutz, L.N., Sports Health, 2024, 10.1177/19417381231217744
  • Normalization of diastolic dysfunction in type 2 diabetics after exercise training, Poirier, P., Dumesnil, J.-G., Bogaty, P., Garneau, C., Legault, S., Brassard, P., Medicine and Science in Sports and Exercise, 2007, 10.1249/mss.0b013e318145b642
  • Directional sensitivity of the cerebral pressure–flow relationship in young healthy individuals trained in endurance and resistance exercise, Brassard, P., Smirl, J.D., Korad, S., Perry, B.G., Labrecque, L., Roy, M.-A., Experimental Physiology, 2022, 10.1113/EP090159
  • Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males, Nielsen, H.B., Secher, N.H., Stallknecht, B., Nordby, P., Wissenberg, M., Homann, P.H., Brassard, P., Rasmussen, P., Seifert, T., American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 2009, 10.1152/ajpregu.00277.2009
  • The beta-1 adrenergic antagonist, atenolol, decreases acylation stimulating protein, exercise capacity and plasma free fatty acids in men with type 2 diabetes, Cianflone, K., Poirier, P., Lacroix, S., Brassard, P., Méthot, J., Ferland, A., Smith, J., Nutrition, Metabolism and Cardiovascular Diseases, 2012, 10.1016/j.numecd.2010.08.008
  • The role of the autonomic nervous system in cerebral blood flow regulation in stroke: A review, Minhas, J.S., Beishon, L.C., Brassard, P., Robinson, T.G., Panerai, R.B., Davies, A., Roy, S., Mankoo, A., Autonomic Neuroscience: Basic and Clinical, 2023, 10.1016/j.autneu.2023.103082
  • Influence of norepinephrine and phenylephrine on frontal lobe oxygenation during cardiopulmonary bypass in patients with diabetes, Bussières, J.S., Caouette, M., Ainslie, P.N., Poirier, P., Gagné, N., Martin, M., Pelletier, C., Brassard, P., Journal of Cardiothoracic and Vascular Anesthesia, 2014, 10.1053/j.jvca.2013.09.006
  • The effect of supine cycling and progressive lower body negative pressure on cerebral blood velocity responses, Smirl, J.D., Brassard, P., Emery, C.A., Phillips, A.A., Johnson, N.E., Van Roessel, R.K., Burma, J.S., Miutz, L.N., Journal of Applied Physiology, 2023, 10.1152/japplphysiol.00758.2022
  • Impact of exercise training on muscle function and ergoreflex in Fontan patients: A pilot study, Jobin, J., Perron, J., Cloutier, A., Houde, C., Nadreau, E., Noël, M., Martin, J., Poirier, P., Brassard, P., International Journal of Cardiology, 2006, 10.1016/j.ijcard.2005.02.038
  • Effect of PPARγ agonist on aerobic exercise capacity in relation to body fat distribution in men with type 2 diabetes mellitus and coronary artery disease: A 1-yr randomized study, Piché, M.-E., Costerousse, O., Després, J.-P., Bertrand, O.F., Arsenault, B.J., Brassard, P., Poirier, P., Bastien, M., American Journal of Physiology - Endocrinology and Metabolism, 2019, 10.1152/ajpendo.00505.2018
  • Sympathetic Vasoconstrictor Responsiveness of the Leg Vasculature during Experimental Endotoxemia and Hypoxia in Humans, Rosenmeier, J.B., Secher, N.H., Thaning, P., Zaar, M., Brassard, P., Critical Care Medicine, 2016, 10.1097/CCM.0000000000001486
  • Maternal and Fetal Cardiovascular Responses to Acute High-Intensity Interval and Moderate-Intensity Continuous Training Exercise during Pregnancy: A Randomized Crossover Trial, Davenport, M.H., Brassard, P., Labrecque, L., Vanden Berg, E.R., Hazell, T.J., Wowdzia, J.B., Obstetrical and Gynecological Survey, 2023, 10.1097/OGX.0000000000001218
  • Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension, Secher, N.H., Jørgensen, T.B., Brassard, P., Nissen, P., Neurocritical Care, 2010, 10.1007/s12028-009-9313-x
  • Losing the dogmatic view of cerebral autoregulation, Ainslie, P.N., Couture, E.J., Denault, A.Y., Lucas, S.J.E., Hoiland, R.L., Caldwell, H.G., Tymko, M.M., Smirl, J.D., Labrecque, L., Brassard, P., Physiological Reports, 2021, 10.14814/phy2.14982
  • Exercise-induced potentiation of the acute hypoxic ventilatory response: Neural mechanisms and implications for cerebral blood flow, Silva, B.M., Brassard, P., Rashid, A., Oliveira, D.M., Experimental Physiology, 2024, 10.1113/EP091330
  • Effects of age and sex on middle cerebral artery blood velocity and flow pulsatility index across the adult lifespan, Billinger, S.A., Labrecque, L., Howery, A.J., Miller, K.B., Ward, J.L., Brassard, P., Barnes, J.N., Kaufman, C.S., Aaron, S.E., Alwatban, M.R., Journal of Applied Physiology, 2021, 10.1152/japplphysiol.00926.2020
  • Effects of noradrenaline and phenylephrine on cerebral oxygen saturation during cardiopulmonary bypass in cardiac surgery, Patrice Brassard, Manon Caouette, Pierre Voisine, Paul Poirier, Stephan Langevin, Jean S. Bussières, Etienne J. Couture, Edouard Marques, Experimental Physiology, 2025, 10.1113/EP092387
  • My sojourn with cerebral sympathetic nervous activity, Patrice Brassard, Experimental Physiology, 2024, 10.1113/EP092029
  • Acute isometric and dynamic exercise do not alter cerebral sympathetic nerve activity in healthy humans, Brassard, P., Ainslie, P.N., Châteauvert, N., Fortin, M., Langevin, S., Coombs, G.B., Imhoff, S., Labrecque, L., Vieira-Coelho, M.A., Drapeau, A., Tymko, M.M., Journal of Cerebral Blood Flow and Metabolism, 2024, 10.1177/0271678X241248228
  • Dynamic cerebral autoregulation of endurance-trained men following 6 weeks of high-intensity interval training to exhaustion, Brassard, P., Malenfant, S., Le Blanc, O., Paquette, M., Imhoff, S., Labrecque, L., Drapeau, A., bioRxiv, 2019, 10.1101/605667
  • Cerebral blood flow regulation, exercise and pregnancy: Why should we care?, Brassard, P., Marc, I., Bisson, M., Clinical Science, 2016, 10.1042/CS20150694
  • Endurance training enhances BDNF release from the human brain, Secher, N.H., Nielsen, H.B., Pilegaard, H., Jakobsen, A.H., Adser, H., Stallknecht, B., Nordby, P., Rasmussen, P., Wissenberg, M., Brassard, P., Seifert, T., American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 2010, 10.1152/ajpregu.00525.2009
  • Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain, Secher, N.H., Nielsen, H.B., Evans, K.A., Homann, P., Zaar, M., Brassard, P., Seifert, T., Bohm, A.M., Rasmussen, P., Overgaard, M., FASEB Journal, 2012, 10.1096/fj.11-191999
  • Left ventricular diastolic function and exercise capacity in diabetes, Poirier, P., Brassard, P., Diabetologia, 2009, 10.1007/s00125-009-1302-2
  • Functional implications of impaired dynamic cerebral autoregulation in young healthy women; A comparative investigation, Brassard, P., Bailey, D.M., Smirl, J.D., Drapeau, A., Malenfant, S., Blanc, O.L., Paquette, M., Imhoff, S., Rahimaly, K., Labrecque, L., bioRxiv, 2018, 10.1101/406827
  • Cerebral water and ion balance remains stable when humans are exposed to acute hypoxic exercise, Nordsborg, N.B., Secher, N.H., Krustrup, P., Overgaard, M., Seifert, T., Brassard, P., Rasmussen, P., Avnstorp, M.B., High Altitude Medicine and Biology, 2015, 10.1089/ham.2014.1075
  • Impact of type 2 diabetes on cardiorespiratory function and exercise performance, Brassard, P., Legault, S., Poirier, P., Ferland, A., Chouinard, A., Labrecque, L., duManoir, G.R., Caron, J., Physiological Reports, 2017, 10.14814/phy2.13145
  • Influence of an osteopathic manipulative intervention on cerebral blood velocity changes: Do we have the whole story to appropriately interpret the data?, Brassard, P., Imhoff, S., Drapeau, A., Journal of Osteopathic Medicine, 2021, 10.1515/jom-2021-0225
  • Diminished dynamic cerebral autoregulatory capacity with forced oscillations in mean arterial pressure with elevated cardiorespiratory fitness, Brassard, P., Smirl, J.D., Bailey, D.M., Lucas, S.J.E., Malenfant, S., Le Blanc, O., Paquette, M., Imhoff, S., Rahimaly, K., Labrecque, L., Physiological Reports, 2017, 10.14814/phy2.13486
  • Impact of Successive Sets of High-Intensity Leg Press on Cerebral Hemodynamics Across Menstrual Cycle Phases, Baraa K. Al-Khazraji, Stuart M. Phillips, Patrice Brassard, Yixue Mei, Brandan Wilson, Huseyn A. Ismayilov, Alysha C. D'Souza, Matin Borhani, Elric Y. Allison, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2025, 10.1152/ajpregu.00257.2024
  • Rosiglitazone lowers resting and blood pressure response to exercise in men with type 2 diabetes: A 1-year randomized study, Poirier, P., Costerousse, O., Després, J.-P., Bertrand, O.F., Arsenault, B.J., Brassard, P., Laberge, A.-S., Piché, M.-E., Diabetes, Obesity and Metabolism, 2018, 10.1111/dom.13293
  • Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis, Agharazii, M., Brassard, P., Drapeau, A., Labrecque, L., Obeid, H., Paré, M., Physiological Reports, 2023, 10.14814/phy2.15595
  • Cerebral oxygenation in health and disease, Secher, N.H., Ainslie, P.N., Brassard, P., Frontiers in Physiology, 2014, 10.3389/fphys.2014.00458
  • Nitrite and S-Nitrosohemoglobin Exchange Across the Human Cerebral and Femoral Circulation: Relationship to Basal and Exercise Blood Flow Responses to Hypoxia, Secher, N.H., Raven, P.B., Nielsen, H.B., Zaar, M., Brassard, P., Seifert, T., Bohm, A.M., Evans, K.A., Overgaard, M., Rasmussen, P., Bailey, D.M., Circulation, 2017, 10.1161/CIRCULATIONAHA.116.024226
  • Prenatal exercise and cardiovascular health (PEACH) study: Impact of acute and chronic exercise on cerebrovascular hemodynamics and dynamic cerebral autoregulation, Davenport, M.H., Steinback, C.D., Brassard, P., Rosenberger, J.A., Labrecque, L., Skow, R.J., Journal of Applied Physiology, 2022, 10.1152/japplphysiol.00446.2021
  • Influence of glycemic control on pulmonary function and heart rate in response to exercise in subjects with type 2 diabetes mellitus, Poirier, P., Jobin, J., Desmeules, M., Bogaty, P., Ferland, A., Brassard, P., Metabolism: Clinical and Experimental, 2006, 10.1016/j.metabol.2006.06.025
  • Hypoxia compounds exercise-induced free radical formation in humans; partitioning contributions from the cerebral and femoral circulation, Secher, N.H., McCord, J.M., Young, I.S., McEneny, J., Raven, P.B., Homann, P.H., Nordsborg, N.B., Brassard, P., Nielsen, H.B., Zaar, M., Bohm, A.M., Evans, K.A., Rasmussen, P., Bailey, D.M., Free Radical Biology and Medicine, 2018, 10.1016/j.freeradbiomed.2018.05.090
  • Dynamic cerebral autoregulation and cerebrovascular carbon dioxide reactivity in middle and posterior cerebral arteries in young endurance-trained women, Brassard, P., Imhoff, S., Rahimaly, K., Drapeau, A., Labrecque, L., Journal of Applied Physiology, 2021, 10.1152/japplphysiol.00963.2020
  • Influence of high-intensity interval training to exhaustion on the directional sensitivity of the cerebral pressure-flow relationship in young endurance-trained men, Brassard, P., Smirl, J.D., Imhoff, S., Drapeau, A., Labrecque, L., Roy, M.-A., Abbariki, F., Physiological Reports, 2022, 10.14814/phy2.15384
  • Rosiglitazone influences adipose tissue distribution without deleterious impact on heart rate variability in coronary heart disease patients with type 2 diabetes, Poirier, P., Alméras, N., Costerousse, O., Després, J.-P., Bertrand, O.F., Brassard, P., Grenier, A., Clinical Autonomic Research, 2016, 10.1007/s10286-016-0373-7
  • A systematic review, meta-analysis and meta-regression amalgamating the driven approaches used to quantify dynamic cerebral autoregulation, Smirl, J.D., Brassard, P., Labrecque, L., Kennedy, C.M., Roy, M.-A., Burma, J.S., Journal of Cerebral Blood Flow and Metabolism, 2024, 10.1177/0271678X241235878
  • Central and peripheral blood flow during exercise with a continuous-flow left ventricular assist device constant versus increasing pump speed: A pilot study, Madsen, P.L., Secher, N.H., Sander, K., Olsen, P.S., Hansen, P.B., Boesgaard, S., Hassager, C., Møller, J.E., Gustafsson, F., Nordsborg, N., Jensen, A.S., Brassard, P., Circulation: Heart Failure, 2011, 10.1161/CIRCHEARTFAILURE.110.958041
  • Skeletal muscle endurance and muscle metabolism in patients with chronic heart failure, Jobin, J., Poirier, P., Leblanc, M.-H., Simard, C., Allaire, J., LeBlanc, P., Doyon, J.-F., Noël, M., Maltais, F., Brassard, P., Canadian Journal of Cardiology, 2006, 10.1016/S0828-282X(06)70923-0
  • Dynamic cerebral autoregulation quantification with spontaneous arterial blood pressure oscillations: Is transfer function analysis our best option?, Smirl, J.D., Brassard, P., Experimental Physiology, 2024, 10.1113/EP091900
  • Multi-metrics assessment of dynamic cerebral autoregulation in middle and posterior cerebral arteries in young fit women, Brassard, P., Billaut, F., Imhoff, S., Rahimaly, K., Drapeau, A., Labrecque, L., bioRxiv, 2020, 10.1101/2020.05.25.114447

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Lawrence Labrecque - Doctorat - En cours
  • Audrey Drapeau - Doctorat - En cours
  • Shahrzad Soleimani Dehnavi - Doctorat - En cours
  • Mahmoudreza Taghizadeh - Doctorat - En cours
  • Marc-Antoine Roy - Doctorat - En cours
  • Guillaume Salamin - Maîtrise avec mémoire - 2011/05
  • Émilie Pérusse-Lachance - Doctorat - 2012/09
  • Claudine Pelletier - Maîtrise avec mémoire - 2012/09
  • Sandrine Hegg-Deloye - Doctorat - 2014/01
  • Myriam Paquette - Maîtrise avec mémoire - 2014/09
  • Olivier Le Blanc - Maîtrise avec mémoire - 2015/09
  • Faezeh Abbariki - Maîtrise avec mémoire - 2021/09
  • Nassif Chamoun - Maîtrise avec mémoire - 2023/05
  • Mathilde Paré - Maîtrise avec mémoire - 2023/09
  • Edouard Marques - Maîtrise avec mémoire - 2024/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Kinésiologie

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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