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Patrick Rochette

Professeur titulaire

Patrick Rochette
Patrick.Rochette@orlo.ulaval.ca
Centre de recherche en organogenèse expérimentale
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire
Neurosciences et santé mentale
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Cancer de la peau
  • Carcinogénèse
  • Environnement et cancer
  • Apoptose et cancer
Génétique humaine
  • Génétique moléculaire
  • Mutation (processus)
Neurosciences, santé mentale et toxicomanies
  • Maladies de l'oeil et du système visuel
  • Système visuel
Vieillissement
  • Dégénérescence cellulaire
  • Âge et facteurs de risques

Projets de recherche

  • Toxicité des rayons ultraviolets sous l’angle de la mitochondrie - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2023-04-01 au 2028-03-31
  • Fuchs endothelial corneal dystrophy and corneal transplantation: The traditional paradigm revisited - Instituts de recherche en santé du Canada - Subvention Projet, Université de Montréal, co-chercheur - 2019-10-01 au 2024-09-30
  • Toxicité de la lumière et dysfonctionnement mitochondrial dans l’oeil humain - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2021-07-01 au 2024-06-30
  • Journée annuelle de la recherche en ophtalmologie - Allergan inc., Bausch Health, Canada Inc., chercheur principal - 2019-04-23 au 2021-03-31

Publications

  • Synergistic Toxicity of Pollutant and Ultraviolet Exposure from a Mitochondrial Perspective, Patrick J. Rochette, Laurent Marrot, Valérie Haydont, Christian Salesse, Alicia Montoni, Marc-Antoine Millette, Frédéric Pelchat, Sébastien Méthot, Eloïse Larnac, International Journal of Molecular Sciences, 2024, 10.3390/ijms25179146
  • SW480, a p53 double-mutant cell line retains proficiency for some p53 functions., , Journal of molecular biology, 2005, 10.1016/j.jmb.2005.06.033
  • Rescue of the transcription factors Sp1 and NFI in human skin keratinocytes through a feeder-layer-dependent suppression of the proteasome activity., , Journal of molecular biology, 2012, 10.1016/j.jmb.2012.01.021
  • [Mapping DNA damage to understand somatic mutagenesis]., , Medecine sciences : M/S, 2010, 10.1051/medsci/2010262193
  • Extracellular Matrix and Integrin Expression Profiles in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Model., , Tissue engineering. Part A, 2017, 10.1089/ten.tea.2017.0128
  • Impact of ultraviolet radiation on dermal and epidermal DNA damage in a human pigmented bilayered skin substitute., , Journal of tissue engineering and regenerative medicine, 2019, 10.1002/term.2959
  • Chronology of cellular events related to mitochondrial burnout leading to cell death in Fuchs endothelial corneal dystrophy. , , Scientific reports, 2020, 10.1038/s41598-020-62602-x
  • Influence of cytosine methylation on ultraviolet-induced cyclobutane pyrimidine dimer formation in genomic DNA., , Mutation research, 2009, 10.1016/j.mrfmmm.2009.02.008
  • The use of tissue-engineered skin to demonstrate the negative effect of CXCL5 on epidermal UV radiation-induced CPD repair efficiency. , , The British journal of dermatology, 2020, 10.1111/bjd.19117
  • Influence of a pre-stimulation with chronic low-dose UVB on stress response mechanisms in human skin fibroblasts., , PloS one, 2017, 10.1371/journal.pone.0173740
  • Indenopyrene and Blue-Light Co-Exposure Impairs the Tightly Controlled Activation of Xenobiotic Metabolism in Retinal Pigment Epithelial Cells: A Mechanism for Synergistic Toxicity, Patrick J. Rochette, Corinne Zinflou, International Journal of Molecular Sciences, 2023, 10.3390/ijms242417385
  • Telomere Length Measurement in Different Ocular Structures: A Potential Implication in Corneal Endothelium Pathogenesis., , Investigative ophthalmology & visual science, 2016, 10.1167/iovs.16-19878
  • Short wavelengths filtering properties of sunglasses on the Canadian market: are we protected?, , Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2017, 10.1016/j.jcjo.2017.09.006
  • Association of Telomere Length with Breast Cancer Prognostic Factors., , PloS one, 2016, 10.1371/journal.pone.0161903
  • Ultraviolet A-induced oxidation in cornea: Characterization of the early oxidation-related events., , Free radical biology & medicine, 2017, 10.1016/j.freeradbiomed.2017.03.022
  • UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells., , Nucleic acids research, 2003, 10.1093/nar/gkg402
  • Chronic UVA1 Irradiation of Human Dermal Fibroblasts: Persistence of DNA Damage and Validation of a Cell Cultured-Based Model of Photoaging., , The Journal of investigative dermatology, 2019, 10.1016/j.jid.2019.02.022
  • Bcl-2 is the target of a UV-inducible apoptosis switch and a node for UV signaling., , Proceedings of the National Academy of Sciences of the United States of America, 2007, 10.1073/pnas.0701318104
  • Human cells bearing homozygous mutations in the DNA mismatch repair genes hMLH1 or hMSH2 are fully proficient in transcription-coupled nucleotide excision repair., , Oncogene, 2002, 10.1038/sj.onc.1205641
  • Potential of sub-microsecond laser pulse shaping for controlling microcavitation in selective retinal therapies., , Biomedical optics express, 2019, 10.1364/boe.11.000109
  • Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL., , Mechanisms of ageing and development, 2008, 10.1016/j.mad.2007.12.007
  • Enhancement of UVB-induced DNA damage repair after a chronic low-dose UVB pre-stimulation., , DNA repair, 2018, 10.1016/j.dnarep.2018.01.008
  • The Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case–Control Study, Patrick J Rochette, Serge Bourgault, David Simonyan, Justine Rheault, Thierry Hamel, Clinical Ophthalmology, 2021, 10.2147/OPTH.S300461
  • Reduction of DNA damage repair efficiency and accumulation of residual damage following chronic UVB-irradiation of HaCaT cells, Patrick J. Rochette, Marie M. Dorr, PLOS ONE, 2023, 10.1371/journal.pone.0283572
  • Human telomeres are hypersensitive to UV-induced DNA Damage and refractory to repair., , PLoS genetics, 2010, 10.1371/journal.pgen.1000926
  • Ultraviolet light-induced cyclobutane pyrimidine dimers in rabbit eyes., , Photochemistry and photobiology, 2011, 10.1111/j.1751-1097.2011.00977.x
  • The 3895-bp mitochondrial DNA deletion in the human eye: a potential involvement in corneal ageing and macular degeneration., , Mutagenesis, 2013, 10.1093/mutage/ges071
  • Lipid Peroxidation as the Mechanism Underlying Polycyclic Aromatic Hydrocarbons and Sunlight Synergistic Toxicity in Dermal Fibroblasts, Patrick J. Rochette, Laurent Marrot, Valérie Haydont, Alicia Montoni, Eloïse Larnac, International Journal of Molecular Sciences, 2024, 10.3390/ijms25031905
  • Contribution of Sp1 to Telomerase Expression and Activity in Skin Keratinocytes Cultured With a Feeder Layer., , Journal of cellular physiology, 2015, 10.1002/jcp.24706
  • Mitochondrial DNA common deletion in the human eye: a relation with corneal aging., , Mechanisms of ageing and development, 2012, 10.1016/j.mad.2012.01.002
  • Apple extract (Malus sp.) and rutin as photochemopreventive agents: Evaluation of UVB-induced alterations on skin biopsies and tissue-engineered skin. , , Rejuvenation research, 2020, 10.1089/rej.2019.2219
  • Absorption of blue light by cigarette smoke components is highly toxic for retinal pigmented epithelial cells., , Archives of toxicology, 2018, 10.1007/s00204-018-2344-3
  • The T414G mitochondrial DNA mutation: a biomarker of ageing in human eye, Patrick J Rochette, Marie M Dorr, Anne-Sophie Gary, Mutagenesis, 2021, 10.1093/mutage/geab003
  • Persistence and Tolerance of DNA Damage Induced by Chronic UVB Irradiation of the Human Genome., , The Journal of investigative dermatology, 2017, 10.1016/j.jid.2017.08.044
  • Wavelength-dependent ultraviolet induction of cyclobutane pyrimidine dimers in the human cornea., , Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2013, 10.1039/c3pp25408a
  • Restoration of Mitochondrial Integrity, Telomere Length, and Sensitivity to Oxidation by In Vitro Culture of Fuchs' Endothelial Corneal Dystrophy Cells., , Investigative ophthalmology & visual science, 2016, 10.1167/iovs.16-20551
  • Faster DNA Repair of Ultraviolet-Induced Cyclobutane Pyrimidine Dimers and Lower Sensitivity to Apoptosis in Human Corneal Epithelial Cells than in Epidermal Keratinocytes., , PloS one, 2016, 10.1371/journal.pone.0162212
  • Modifications in stromal extracellular matrix of aged corneas can be induced by ultraviolet A irradiation., , Aging cell, 2015, 10.1111/acel.12324
  • MLKL, a new actor of UVB-induced apoptosis in human diploid dermal fibroblasts, Patrick J. Rochette, Alicia Montoni, Sophie Amouret, Anne-Sophie Gary, Cell Death Discovery, 2024, 10.1038/s41420-024-02004-4
  • Function-Related Protein Expression in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Models., , The American journal of pathology, 2018, 10.1016/j.ajpath.2018.03.014
  • Implication of ultraviolet light in the etiology of uveal melanoma: A review., , Photochemistry and photobiology, 2013, 10.1111/php.12161
  • MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication., , The EMBO journal, 2009, 10.1038/emboj.2009.235
  • Pyrimidine (6-4) pyrimidone photoproduct mapping after sublethal UVC doses: nucleotide resolution using terminal transferase-dependent PCR., , Photochemistry and photobiology, 2006, 10.1562/2004-12-01-ra-390

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Eloïse Larnac - Doctorat - En cours
  • Vida Omrani - Doctorat - En cours
  • Sophie Amouret - Doctorat - En cours
  • Sébastien Gendron - Maîtrise avec mémoire - 2014/01
  • Justin Mallet - Doctorat - 2016/01
  • Pascal Deladurantaye - Maîtrise avec mémoire - 2016/09
  • Roxanne Bérubé - Maîtrise avec mémoire - 2017/09
  • Marie Catherine Drigeard Desgarnier - Doctorat - 2017/09
  • Marie-Christine Lambert - Maîtrise avec mémoire - 2019/01
  • Marie Dorr - Doctorat - 2019/05
  • Sébastien Méthot - Maîtrise avec mémoire - 2020/01
  • Anne-Sophie Gary - Doctorat - 2021/05
  • Corinne Zinflou - Doctorat - 2021/09
  • Alexe Grenier - Doctorat - 2022/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Sciences cliniques et biomédicales

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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