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Patrick Rochette
Professeur titulaire
Centre de recherche en organogenèse expérimentale
Centre de recherche du CHU de Québec - Université Laval
Contribution à la recherche
Thématiques de recherche de la Faculté de médecine
- Médecine régénératrice et médecine moléculaire
- Neurosciences et santé mentale
- Oncologie
Projets de recherche en cours
- Effect of compound TAED017 on telomere lengths and oxidation-related consequences of rabbit corneas and on Fuchs endothelial corneal dystrophy explants. - TelomEye Pharmaceuticals, chercheur principal - 2024-12-23 au 2029-12-25
- Toxicité des rayons ultraviolets sous l’angle de la mitochondrie - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2023-04-01 au 2028-03-31
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Financements des 2 dernières années
- Fuchs endothelial corneal dystrophy and corneal transplantation: The traditional paradigm revisited - Instituts de recherche en santé du Canada - Subvention Projet, Université de Montréal, co-chercheur - 2019-10-01 au 2024-09-30
- Toxicité de la lumière et dysfonctionnement mitochondrial dans l’oeil humain - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2021-07-01 au 2024-06-30
- Journée annuelle de la recherche en ophtalmologie - Allergan inc., Bausch Health, Canada Inc., chercheur principal - 2019-04-23 au 2021-03-31
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Publications
- Restoration of Mitochondrial Integrity, Telomere Length, and Sensitivity to Oxidation by In Vitro Culture of Fuchs' Endothelial Corneal Dystrophy Cells., , Investigative ophthalmology & visual science, 2016, 10.1167/iovs.16-20551
- Influence of a pre-stimulation with chronic low-dose UVB on stress response mechanisms in human skin fibroblasts., , PloS one, 2017, 10.1371/journal.pone.0173740
- The T414G mitochondrial DNA mutation: a biomarker of ageing in human eye, Patrick J Rochette, Marie M Dorr, Anne-Sophie Gary, Mutagenesis, 2021, 10.1093/mutage/geab003
- Chronic UVA1 Irradiation of Human Dermal Fibroblasts: Persistence of DNA Damage and Validation of a Cell Cultured-Based Model of Photoaging., , The Journal of investigative dermatology, 2019, 10.1016/j.jid.2019.02.022
- Absorption of blue light by cigarette smoke components is highly toxic for retinal pigmented epithelial cells., , Archives of toxicology, 2018, 10.1007/s00204-018-2344-3
- MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication., , The EMBO journal, 2009, 10.1038/emboj.2009.235
- Impact of ultraviolet radiation on dermal and epidermal DNA damage in a human pigmented bilayered skin substitute., , Journal of tissue engineering and regenerative medicine, 2019, 10.1002/term.2959
- UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells., , Nucleic acids research, 2003, 10.1093/nar/gkg402
- Faster DNA Repair of Ultraviolet-Induced Cyclobutane Pyrimidine Dimers and Lower Sensitivity to Apoptosis in Human Corneal Epithelial Cells than in Epidermal Keratinocytes., , PloS one, 2016, 10.1371/journal.pone.0162212
- Function-Related Protein Expression in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Models., , The American journal of pathology, 2018, 10.1016/j.ajpath.2018.03.014
- Modifications in stromal extracellular matrix of aged corneas can be induced by ultraviolet A irradiation., , Aging cell, 2015, 10.1111/acel.12324
- Contribution of Sp1 to Telomerase Expression and Activity in Skin Keratinocytes Cultured With a Feeder Layer., , Journal of cellular physiology, 2015, 10.1002/jcp.24706
- Potential of sub-microsecond laser pulse shaping for controlling microcavitation in selective retinal therapies., , Biomedical optics express, 2019, 10.1364/boe.11.000109
- Bcl-2 is the target of a UV-inducible apoptosis switch and a node for UV signaling., , Proceedings of the National Academy of Sciences of the United States of America, 2007, 10.1073/pnas.0701318104
- Wavelength-dependent ultraviolet induction of cyclobutane pyrimidine dimers in the human cornea., , Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2013, 10.1039/c3pp25408a
- Ultraviolet A-induced oxidation in cornea: Characterization of the early oxidation-related events., , Free radical biology & medicine, 2017, 10.1016/j.freeradbiomed.2017.03.022
- Implication of ultraviolet light in the etiology of uveal melanoma: A review., , Photochemistry and photobiology, 2013, 10.1111/php.12161
- Enhancement of UVB-induced DNA damage repair after a chronic low-dose UVB pre-stimulation., , DNA repair, 2018, 10.1016/j.dnarep.2018.01.008
- Ultraviolet light-induced cyclobutane pyrimidine dimers in rabbit eyes., , Photochemistry and photobiology, 2011, 10.1111/j.1751-1097.2011.00977.x
- Short wavelengths filtering properties of sunglasses on the Canadian market: are we protected?, , Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2017, 10.1016/j.jcjo.2017.09.006
- Extracellular Matrix and Integrin Expression Profiles in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Model., , Tissue engineering. Part A, 2017, 10.1089/ten.tea.2017.0128
- Chronology of cellular events related to mitochondrial burnout leading to cell death in Fuchs endothelial corneal dystrophy. , , Scientific reports, 2020, 10.1038/s41598-020-62602-x
- Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL., , Mechanisms of ageing and development, 2008, 10.1016/j.mad.2007.12.007
- Indenopyrene and Blue-Light Co-Exposure Impairs the Tightly Controlled Activation of Xenobiotic Metabolism in Retinal Pigment Epithelial Cells: A Mechanism for Synergistic Toxicity, Patrick J. Rochette, Corinne Zinflou, International Journal of Molecular Sciences, 2023, 10.3390/ijms242417385
- Apple extract (Malus sp.) and rutin as photochemopreventive agents: Evaluation of UVB-induced alterations on skin biopsies and tissue-engineered skin. , , Rejuvenation research, 2020, 10.1089/rej.2019.2219
- [Mapping DNA damage to understand somatic mutagenesis]., , Medecine sciences : M/S, 2010, 10.1051/medsci/2010262193
- The Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case–Control Study, Patrick J Rochette, Serge Bourgault, David Simonyan, Justine Rheault, Thierry Hamel, Clinical Ophthalmology, 2021, 10.2147/OPTH.S300461
- Telomere Length Measurement in Different Ocular Structures: A Potential Implication in Corneal Endothelium Pathogenesis., , Investigative ophthalmology & visual science, 2016, 10.1167/iovs.16-19878
- Persistence and Tolerance of DNA Damage Induced by Chronic UVB Irradiation of the Human Genome., , The Journal of investigative dermatology, 2017, 10.1016/j.jid.2017.08.044
- Rescue of the transcription factors Sp1 and NFI in human skin keratinocytes through a feeder-layer-dependent suppression of the proteasome activity., , Journal of molecular biology, 2012, 10.1016/j.jmb.2012.01.021
- Human cells bearing homozygous mutations in the DNA mismatch repair genes hMLH1 or hMSH2 are fully proficient in transcription-coupled nucleotide excision repair., , Oncogene, 2002, 10.1038/sj.onc.1205641
- Reduction of DNA damage repair efficiency and accumulation of residual damage following chronic UVB-irradiation of HaCaT cells, Patrick J. Rochette, Marie M. Dorr, PLOS ONE, 2023, 10.1371/journal.pone.0283572
- Association of Telomere Length with Breast Cancer Prognostic Factors., , PloS one, 2016, 10.1371/journal.pone.0161903
- Pyrimidine (6-4) pyrimidone photoproduct mapping after sublethal UVC doses: nucleotide resolution using terminal transferase-dependent PCR., , Photochemistry and photobiology, 2006, 10.1562/2004-12-01-ra-390
- Influence of cytosine methylation on ultraviolet-induced cyclobutane pyrimidine dimer formation in genomic DNA., , Mutation research, 2009, 10.1016/j.mrfmmm.2009.02.008
- SW480, a p53 double-mutant cell line retains proficiency for some p53 functions., , Journal of molecular biology, 2005, 10.1016/j.jmb.2005.06.033
- MLKL, a new actor of UVB-induced apoptosis in human diploid dermal fibroblasts, Patrick J. Rochette, Alicia Montoni, Sophie Amouret, Anne-Sophie Gary, Cell Death Discovery, 2024, 10.1038/s41420-024-02004-4
- Lipid Peroxidation as the Mechanism Underlying Polycyclic Aromatic Hydrocarbons and Sunlight Synergistic Toxicity in Dermal Fibroblasts, Patrick J. Rochette, Laurent Marrot, Valérie Haydont, Alicia Montoni, Eloïse Larnac, International Journal of Molecular Sciences, 2024, 10.3390/ijms25031905
- Human telomeres are hypersensitive to UV-induced DNA Damage and refractory to repair., , PLoS genetics, 2010, 10.1371/journal.pgen.1000926
- The 3895-bp mitochondrial DNA deletion in the human eye: a potential involvement in corneal ageing and macular degeneration., , Mutagenesis, 2013, 10.1093/mutage/ges071
- Mitochondrial DNA common deletion in the human eye: a relation with corneal aging., , Mechanisms of ageing and development, 2012, 10.1016/j.mad.2012.01.002
- The use of tissue-engineered skin to demonstrate the negative effect of CXCL5 on epidermal UV radiation-induced CPD repair efficiency. , , The British journal of dermatology, 2020, 10.1111/bjd.19117
- Synergistic Toxicity of Pollutant and Ultraviolet Exposure from a Mitochondrial Perspective, Patrick J. Rochette, Laurent Marrot, Valérie Haydont, Christian Salesse, Alicia Montoni, Marc-Antoine Millette, Frédéric Pelchat, Sébastien Méthot, Eloïse Larnac, International Journal of Molecular Sciences, 2024, 10.3390/ijms25179146
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2020/04- Sophie Amouret - Doctorat - En cours
- Eloïse Larnac - Doctorat - En cours
- Anne-Sophie Gary - Doctorat - 2021/05
- Corinne Zinflou - Doctorat - 2021/09
- Alexe Grenier - Doctorat - 2022/09
- Marie-Christine Lambert - Doctorat - 2023/01
- Sébastien Méthot - Doctorat - 2023/05
Encadrement d'étudiant(e)s
Direction de recherche dans les domaines suivants :
- Biologie cellulaire et moléculaire
- Sciences cliniques et biomédicales
En savoir plus sur les programmes
Disponibilité d'encadrement d'étudiant(e)s
Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.
Envoyer un courriel*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.