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Patrick Rochette

Professeur titulaire

Patrick Rochette
Patrick.Rochette@orlo.ulaval.ca
Centre de recherche en organogenèse expérimentale
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire
Neurosciences et santé mentale
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Cancer de la peau
  • Carcinogénèse
  • Environnement et cancer
  • Apoptose et cancer
Génétique humaine
  • Génétique moléculaire
  • Mutation (processus)
Neurosciences, santé mentale et toxicomanies
  • Maladies de l'oeil et du système visuel
  • Système visuel
Vieillissement
  • Dégénérescence cellulaire
  • Âge et facteurs de risques

Projets de recherche

  • Toxicité des rayons ultraviolets sous l’angle de la mitochondrie - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2023-04-01 au 2028-03-31
  • Fuchs endothelial corneal dystrophy and corneal transplantation: The traditional paradigm revisited - Instituts de recherche en santé du Canada - Subvention Projet, Université de Montréal, co-chercheur - 2019-10-01 au 2024-09-30
  • Toxicité de la lumière et dysfonctionnement mitochondrial dans l’oeil humain - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2021-07-01 au 2024-06-30
  • Journée annuelle de la recherche en ophtalmologie - Allergan inc., Bausch Health, Canada Inc., chercheur principal - 2019-04-23 au 2021-03-31

Publications

  • Pyrimidine (6-4) pyrimidone photoproduct mapping after sublethal UVC doses: nucleotide resolution using terminal transferase-dependent PCR., , Photochemistry and photobiology, 2006, 10.1562/2004-12-01-ra-390
  • Telomere Length Measurement in Different Ocular Structures: A Potential Implication in Corneal Endothelium Pathogenesis., , Investigative ophthalmology & visual science, 2016, 10.1167/iovs.16-19878
  • Function-Related Protein Expression in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Models., , The American journal of pathology, 2018, 10.1016/j.ajpath.2018.03.014
  • Bcl-2 is the target of a UV-inducible apoptosis switch and a node for UV signaling., , Proceedings of the National Academy of Sciences of the United States of America, 2007, 10.1073/pnas.0701318104
  • Extracellular Matrix and Integrin Expression Profiles in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Model., , Tissue engineering. Part A, 2017, 10.1089/ten.tea.2017.0128
  • Influence of a pre-stimulation with chronic low-dose UVB on stress response mechanisms in human skin fibroblasts., , PloS one, 2017, 10.1371/journal.pone.0173740
  • SW480, a p53 double-mutant cell line retains proficiency for some p53 functions., , Journal of molecular biology, 2005, 10.1016/j.jmb.2005.06.033
  • Contribution of Sp1 to Telomerase Expression and Activity in Skin Keratinocytes Cultured With a Feeder Layer., , Journal of cellular physiology, 2015, 10.1002/jcp.24706
  • Rescue of the transcription factors Sp1 and NFI in human skin keratinocytes through a feeder-layer-dependent suppression of the proteasome activity., , Journal of molecular biology, 2012, 10.1016/j.jmb.2012.01.021
  • MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication., , The EMBO journal, 2009, 10.1038/emboj.2009.235
  • Association of Telomere Length with Breast Cancer Prognostic Factors., , PloS one, 2016, 10.1371/journal.pone.0161903
  • The Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case–Control Study, Patrick J Rochette, Serge Bourgault, David Simonyan, Justine Rheault, Thierry Hamel, Clinical Ophthalmology, 2021, 10.2147/OPTH.S300461
  • Potential of sub-microsecond laser pulse shaping for controlling microcavitation in selective retinal therapies., , Biomedical optics express, 2019, 10.1364/boe.11.000109
  • Impact of ultraviolet radiation on dermal and epidermal DNA damage in a human pigmented bilayered skin substitute., , Journal of tissue engineering and regenerative medicine, 2019, 10.1002/term.2959
  • The T414G mitochondrial DNA mutation: a biomarker of ageing in human eye, Patrick J Rochette, Marie M Dorr, Anne-Sophie Gary, Mutagenesis, 2021, 10.1093/mutage/geab003
  • Modifications in stromal extracellular matrix of aged corneas can be induced by ultraviolet A irradiation., , Aging cell, 2015, 10.1111/acel.12324
  • Lipid Peroxidation as the Mechanism Underlying Polycyclic Aromatic Hydrocarbons and Sunlight Synergistic Toxicity in Dermal Fibroblasts, Patrick J. Rochette, Laurent Marrot, Valérie Haydont, Alicia Montoni, Eloïse Larnac, International Journal of Molecular Sciences, 2024, 10.3390/ijms25031905
  • Restoration of Mitochondrial Integrity, Telomere Length, and Sensitivity to Oxidation by In Vitro Culture of Fuchs' Endothelial Corneal Dystrophy Cells., , Investigative ophthalmology & visual science, 2016, 10.1167/iovs.16-20551
  • Synergistic Toxicity of Pollutant and Ultraviolet Exposure from a Mitochondrial Perspective, Patrick J. Rochette, Laurent Marrot, Valérie Haydont, Christian Salesse, Alicia Montoni, Marc-Antoine Millette, Frédéric Pelchat, Sébastien Méthot, Eloïse Larnac, International Journal of Molecular Sciences, 2024, 10.3390/ijms25179146
  • Human cells bearing homozygous mutations in the DNA mismatch repair genes hMLH1 or hMSH2 are fully proficient in transcription-coupled nucleotide excision repair., , Oncogene, 2002, 10.1038/sj.onc.1205641
  • Reduction of DNA damage repair efficiency and accumulation of residual damage following chronic UVB-irradiation of HaCaT cells, Patrick J. Rochette, Marie M. Dorr, PLOS ONE, 2023, 10.1371/journal.pone.0283572
  • Absorption of blue light by cigarette smoke components is highly toxic for retinal pigmented epithelial cells., , Archives of toxicology, 2018, 10.1007/s00204-018-2344-3
  • UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells., , Nucleic acids research, 2003, 10.1093/nar/gkg402
  • The 3895-bp mitochondrial DNA deletion in the human eye: a potential involvement in corneal ageing and macular degeneration., , Mutagenesis, 2013, 10.1093/mutage/ges071
  • MLKL, a new actor of UVB-induced apoptosis in human diploid dermal fibroblasts, Patrick J. Rochette, Alicia Montoni, Sophie Amouret, Anne-Sophie Gary, Cell Death Discovery, 2024, 10.1038/s41420-024-02004-4
  • Chronic UVA1 Irradiation of Human Dermal Fibroblasts: Persistence of DNA Damage and Validation of a Cell Cultured-Based Model of Photoaging., , The Journal of investigative dermatology, 2019, 10.1016/j.jid.2019.02.022
  • Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL., , Mechanisms of ageing and development, 2008, 10.1016/j.mad.2007.12.007
  • Ultraviolet light-induced cyclobutane pyrimidine dimers in rabbit eyes., , Photochemistry and photobiology, 2011, 10.1111/j.1751-1097.2011.00977.x
  • Faster DNA Repair of Ultraviolet-Induced Cyclobutane Pyrimidine Dimers and Lower Sensitivity to Apoptosis in Human Corneal Epithelial Cells than in Epidermal Keratinocytes., , PloS one, 2016, 10.1371/journal.pone.0162212
  • Indenopyrene and Blue-Light Co-Exposure Impairs the Tightly Controlled Activation of Xenobiotic Metabolism in Retinal Pigment Epithelial Cells: A Mechanism for Synergistic Toxicity, Patrick J. Rochette, Corinne Zinflou, International Journal of Molecular Sciences, 2023, 10.3390/ijms242417385
  • [Mapping DNA damage to understand somatic mutagenesis]., , Medecine sciences : M/S, 2010, 10.1051/medsci/2010262193
  • Persistence and Tolerance of DNA Damage Induced by Chronic UVB Irradiation of the Human Genome., , The Journal of investigative dermatology, 2017, 10.1016/j.jid.2017.08.044
  • Influence of cytosine methylation on ultraviolet-induced cyclobutane pyrimidine dimer formation in genomic DNA., , Mutation research, 2009, 10.1016/j.mrfmmm.2009.02.008
  • Apple extract (Malus sp.) and rutin as photochemopreventive agents: Evaluation of UVB-induced alterations on skin biopsies and tissue-engineered skin. , , Rejuvenation research, 2020, 10.1089/rej.2019.2219
  • Enhancement of UVB-induced DNA damage repair after a chronic low-dose UVB pre-stimulation., , DNA repair, 2018, 10.1016/j.dnarep.2018.01.008
  • The use of tissue-engineered skin to demonstrate the negative effect of CXCL5 on epidermal UV radiation-induced CPD repair efficiency. , , The British journal of dermatology, 2020, 10.1111/bjd.19117
  • Implication of ultraviolet light in the etiology of uveal melanoma: A review., , Photochemistry and photobiology, 2013, 10.1111/php.12161
  • Wavelength-dependent ultraviolet induction of cyclobutane pyrimidine dimers in the human cornea., , Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2013, 10.1039/c3pp25408a
  • Human telomeres are hypersensitive to UV-induced DNA Damage and refractory to repair., , PLoS genetics, 2010, 10.1371/journal.pgen.1000926
  • Mitochondrial DNA common deletion in the human eye: a relation with corneal aging., , Mechanisms of ageing and development, 2012, 10.1016/j.mad.2012.01.002
  • Chronology of cellular events related to mitochondrial burnout leading to cell death in Fuchs endothelial corneal dystrophy. , , Scientific reports, 2020, 10.1038/s41598-020-62602-x
  • Short wavelengths filtering properties of sunglasses on the Canadian market: are we protected?, , Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2017, 10.1016/j.jcjo.2017.09.006
  • Ultraviolet A-induced oxidation in cornea: Characterization of the early oxidation-related events., , Free radical biology & medicine, 2017, 10.1016/j.freeradbiomed.2017.03.022

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Vida Omrani - Doctorat - En cours
  • Sophie Amouret - Doctorat - En cours
  • Eloïse Larnac - Doctorat - En cours
  • Sébastien Gendron - Maîtrise avec mémoire - 2014/01
  • Justin Mallet - Doctorat - 2016/01
  • Pascal Deladurantaye - Maîtrise avec mémoire - 2016/09
  • Roxanne Bérubé - Maîtrise avec mémoire - 2017/09
  • Marie Catherine Drigeard Desgarnier - Doctorat - 2017/09
  • Marie-Christine Lambert - Maîtrise avec mémoire - 2019/01
  • Marie Dorr - Doctorat - 2019/05
  • Sébastien Méthot - Maîtrise avec mémoire - 2020/01
  • Anne-Sophie Gary - Doctorat - 2021/05
  • Corinne Zinflou - Doctorat - 2021/09
  • Alexe Grenier - Doctorat - 2022/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Sciences cliniques et biomédicales

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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