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Pierre Douville

Médecin clinicien enseignant titulaire

pierre.douville@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Oncologie
Santé cardiovasculaire, respiratoire et métabolisme
Santé des populations et pratiques optimales en santé

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Diagnostic et détection du cancer
  • Cancer de l'appareil reproducteur
  • Cancer la prostate
Nutrition et métabolisme
  • Maladies lipidiques
  • Diabète
  • Métabolisme
  • Désordres métaboliques
  • Maladies métaboliques
  • Maladies rénales
  • Métabolisme énergétique
Santé circulatoire et respiratoire
  • Athérosclérose
  • Maladie coronarienne
  • Maladies cardiovasculaires

Publications

  • Nomogram to select optimal length of break-in period for new control lots, Douville, P, Carey, RN, Cembrowski, GS, Clinical Chemistry, 2000
  • Serum Prognostic Markers in Head and Neck Cancer, Bairati, Isabelle, Liu, Geoffrey, Duchesne, Thierry, Douville, Pierre, Samson, Elodie, Meyer, Francois, Clinical Cancer Research, 2010, 10.1158/1078-0432.CCR-09-2014
  • EVALUATION OF THE AUTOMATIC ANALYZER HITACHI 705, DOUVILLE, P, FOREST, JC, Clinical Biochemistry, 1982, 10.1016/S0009-9120(82)95809-X
  • THE RELATIONSHIP BETWEEN SERUM FRUCTOSAMINE AND ALBUMIN, COULOMBE, R, SIMARD, S, DOUVILLE, P, SENECAL, PE, Clinica Chimica Acta, 1988, 10.1016/0009-8981(88)90263-X
  • HDL cholesterol and TaqIB cholesteryl ester transfer protein gene polymorphism in renal transplant recipients, Bergeron, J, Douville, P, Despres, JP, Lachance, JG, Noel, R, Houde, I, Vohl, MC, Radeau, T, Nephron, 2000, 10.1159/000045608
  • The impact of warfarin on the rate of progression of aortic stiffness in hemodialysis patients: a longitudinal study, Agharazii, Mohsen, Lebel, Marcel, Lariviere, Richard, Desmeules, Simon, Douville, Pierre, Marquis, Karine, De Serres, Sacha A., Utescu, Mihai Silviu, Poulin, Aurelie, Mac-Way, Fabrice, Nephrology Dialysis Transplantation, 2014, 10.1093/NDT/GFU224
  • Performance of preoperative plasma tumor markers HE4 and CA125 in predicting ovarian cancer mortality in women with epithelial ovarian cancer, Bairati, Isabelle, Douville, Pierre, Tetu, Bernard, Trudel, Dominique, Bachvarov, Dimcho, Plante, Marie, Turcotte, Stephane, Gregoire, Jean, Furrer, Daniela, Plos One, 2019, 10.1371/JOURNAL.PONE.0218621
  • QUALITY-CONTROL FOR AUTOMATED IMMUNOASSAYS - (RANDOM AND BATCH METHODS), DOUVILLE, P, NATIONAL MEETING, CLINICAL LIGAND ASSAY SOCIETY, APRIL 19-23, DETROIT, MICHIGAN, 1993
  • PERFORMANCE OF 3 NEW BLOOD-GLUCOSE REFLECTOMETERS EVALUATED BY NURSING AND LABORATORY STAFFS, GOSSELIN, M, GAUVIN, R, DOUVILLE, P, TALBOT, J, ROUSSEAU, F, FOREST, JC, Clinical Chemistry, 1987
  • Captopril suppression versus salt loading in confirming primary aldosteronism, Lebel, M, Grose, JH, Douville, P, Agharazii, M, Hypertension, 2001, 10.1161/01.HYP.37.6.1440
  • HLA-A, HLA-B AND HLA-DR MATCHING IN CORNEAL TRANSPLANTATION, HEBERT, J, DOUVILLE, P, MICHAUD, R, LAUGHREA, PA, DUBE, I, ROY, R, BOISJOLY, HM, Ophthalmology, 1986, 10.1016/S0161-6420(86)33578-4
  • COPY NUMBER VARIATION OF SEX-STEROID METABOLIZING GENES AS BIOMARKERS OF PROSTATE CANCER RECURRENCE AFTER PROSTATECTOMY: LOOKING AT THE END OF THE ANDROGENIC SIGNAL, Levesque, Eric, Lacombe, Louis, Guillemette, Chantal, Fradet, Yves, Meyer, Francois, Douville, Pierre, Bellemare, Judith, Nadeau, Genevieve, The Journal of Urology, 2010, 10.1016/J.JURO.2010.02.2210
  • The Case vertical bar An unusual case of intoxication, Mac-Way, Fabrice, Douville, Pierre, Isenring, Paul, Lachance, Philippe, Kidney International, 2015, 10.1038/KI.2015.9
  • Bone turnover markers in the management of postmenopausal osteoporosis, Ste-Marie, Louis-Georges, Papaioaonnou, Alexandra, Ooi, Daylily S., Morin, Suzanne, Letendre, Elaine, Lepage, Raymond, Kremer, Richard, Krause, Richard, Krahn, John, Kaiser, Stephanie, Josse, Robert, Jamal, Sophie A., Hanley, David A., Douville, Pierre, Don-Wauchope, Andrew, Dooley, Kent C., Davison, K. Shawn, Cole, David, Adachi, Jonathan D., Nassar, Bassam A., Albert, Caroline, Brown, Jacques P., Clinical Biochemistry, 2009, 10.1016/J.CLINBIOCHEM.2009.04.001
  • 3 REFLECTOMETERS OF THE NEW GENERATION FOR MEASUREMENT OF BLOOD-GLUCOSE EVALUATED IN THE LABORATORY AND ON HOSPITAL WARDS, DOUVILLE, P, TALBOT, J, CARRIER, R, ROUSSEAU, F, FOREST, JC, Clinical Biochemistry, 1987
  • USE OF CLINICAL UTILITY IN EVALUATING VARIOUS QUALITY-CONTROL PROCEDURES, WILLIAMS, SV, LANG, CA, STRAUSS, JF, CEMBROWSKI, GS, DOUVILLE, P, Clinical Chemistry, 1984
  • Impact of dialysate calcium concentration on the progression of aortic stiffness in patients on haemodialysis, Agharazii, Mohsen, Lebel, Marcel, Desmeules, Simon, Douville, Pierre, De Serres, Sacha A., Utescu, Mihai Silviu, Mac-Way, Fabrice, LeBoeuf, Amelie, Nephrology Dialysis Transplantation, 2011, 10.1093/NDT/GFR138
  • Morning plasma aldosterone predicts the subtype of primary aldosteronism independant of sodium intake, Lebel, Marcel, Douville, Pierre, Agharazii, Mohsen, Plamondon, Isabelle, Clinical and Experimental Hypertension, 2007, 10.1080/10641960701195520
  • Performance of preoperative plasma tumor markers HE4 and CA125 in predicting ovarian cancer mortality in women with epithelial ovarian cancer, Bairati, Isabelle, Douville, Pierre, Tetu, Bernard, Trudel, Dominique, Bachvarov, Dimcho, Plante, Marie, Turcotte, Stephane, Gregoire, Jean, Furrer, Daniela, The FASEB Journal, 2019
  • Deletions of the Androgen-Metabolizing UGT2B Genes Have an Effect on Circulating Steroid Levels and Biochemical Recurrence after Radical Prostatectomy in Localized Prostate Cancer, Levesque, Eric, Guillemette, Chantal, Lacombe, Louis, Fradet, Yves, Caron, Patrick, Douville, Pierre, Bao, Bo-Ying, Huang, Shu-Pin, Flageole, Christine, Audet-Walsh, Etienne, Bellemare, Judith, Nadeau, Genevieve, The Journal of Clinical Endocrinology & Metabolism, 2011, 10.1210/JC.2011-1049
  • Performance of preoperative plasma HE4 and CA-125 levels in predicting ovarian cancer mortality in women with epithelial ovarian cancer (EOC), Douville, Pierre, Plante, Marie, Gregoire, Jean, Bairati, Isabelle, Journal of Clinical Oncology, 2017, 10.1200/JCO.2017.35.15_SUPPL.E17076
  • Insulin-like growth factor binding protein 2 is an independant predictor of prostate cancer survival, Fradet, Y, Douville, P, Meyer, F, Audet, JF, Lacombe, L, Inman, BA, The Journal of Urology, 2004
  • The Impact of Germline Genetic Variations in Hydroxysteroid (17-Beta) Dehydrogenases on Prostate Cancer Outcomes After Prostatectomy, Levesque, Eric, Guillemette, Chantal, Douville, Pierre, Fradet, Vincent, Fradet, Yves, Lacombe, Louis, Bellemare, Judith, Audet-Walsh, Etienne, European Urology, 2012, 10.1016/J.EURURO.2011.12.021
  • Monoclonal paraprotein may interfere with the Roche direct HDL-C Plus assay, Lachance, P, Douville, P, Kadri, N, Clinical Chemistry, 2002, 10.1093/CLINCHEM/48.6.964
  • Dietary fibers increase the threshold for discomfort and pain perception during colonic distension in IBS patients, Douville, P, Pare, P, Bradette, M, Marchand, E, Gastroenterology, 1997
  • Impact of age on glomerular filtration estimates, Agharazii, Mohsen, Langlois, Serge, Desmeules, Simon, Talbot, Jean, Martel, Ariane R., Douville, Pierre, Nephrology Dialysis Transplantation, 2009, 10.1093/NDT/GFN473
  • THE REUSE OF SINGLE-USE CARDIAC CATHETERS - SAFETY, ECONOMICAL ETHICAL AND LEGAL ISSUES, MCGREGOR, M, NOOTENS, S, ROY, D, STGEORGES, G, ROBERGE, F, GIROUARD, Y, CHOQUET, Y, BERTRAND, JP, LANIEL, P, GILBERT, G, BOUCHARD, M, ALLARD, L, TREMBLAY, C, PELLETIER, R, LEVESQUE, P, GAUDET, D, DOUVILLE, P, PELLETIER, J, BERGERON, L, BERGERON, D, DESCHAMPS, P, LEROUX, T, BENTOLILA, P, JACOB, R, Canadian Journal of Cardiology, 1994
  • Dietary vitamin D intake and serum 25-hydroxyvitamin D level in relation to disease outcomes in head and neck cancer patients, Bairati, Isabelle, Adjei, Araba, Xu, Wei, Samson, Elodie, Douville, Pierre, Liu, Geoffrey, Meyer, Francois, International Journal of Cancer, 2011, 10.1002/IJC.25496
  • PREDICTION AND VALIDATION OF HEMODIALYSIS DURATION IN INTENTIONAL METHANOL POISONING, Agharazii, Mohsen, Douville, Pierre, De Serres, Sacha A., Desmeules, Simon, Mac-Way, Fabrice, Lachance, Philippe, Nephrology Dialysis Transplantation, 2015, 10.1093/NDT/GFV179.4
  • Comparison of the captopril suppression test with salt loading in confirming the diagnosis of primary aldosteronism, Lebel, M, Grose, J, Douville, P, Agharazii, M, Journal of Hypertension, 2000
  • Effects of acute variation of dialysate calcium concentrations on arterial stiffness and aortic pressure waveform, Agharazii, Mohsen, Desmeules, Simon, Douville, Pierre, Chbinou, Nadia, Utescu, Mihai Silviu, Mac-Way, Fabrice, LeBeouf, Amelie, Nephrology Dialysis Transplantation, 2009, 10.1093/NDT/GFP351
  • Active renin concentration and the aldosterone/renin ratio in screening primary aldosteronism, Douville, P, Lebel, M, American Journal of Hypertension, 2003, 10.1016/S0895-7061(03)00765-9
  • Insulin-like growth factor binding protein 2: An androgen-dependent predictor of prostate cancer survival, Lacombe, L, Fradet, Y, Douville, P, Meyer, F, Audet, JF, Harel, F, Inman, BA, European Urology, 2005, 10.1016/J.EURURO.2004.12.015
  • Impact of the Martin/Hopkins modified equation for estimating LDL-C on lipid target attainment in a high risk patient population, Douville, Pierre, Lagace, Mathieu, Robin, Alex, St-Coeur, Simon, Cartier, Louis-Jacques, Clinical Biochemistry, 2020, 10.1016/J.CLINBIOCHEM.2019.12.002
  • Inherited genetic variations at the UGT1A locus are associated with prostate cancer recurrence after radical prostatectomy, Guillemette, Chantal, Levesque, Eric, Douville, Pierre, Fradet, Yves, Lacombe, Louis, Bellemare, Judith, Audet-Walsh, Etienne, Flageole, Christine, Drug Metabolism Reviews, 2011
  • Effects of electric and magnetic fields from high-power lines on female urinary excretion of 6-sulfatoxymelatonin, Douville, P, Bourdages, M, Kroger, E, Gauvin, D, Masse, B, Gingras, S, Touitou, Y, Dumont, M, Levallois, P, American Journal of Epidemiology, 2001, 10.1093/AJE/154.7.601
  • PERFORMANCE OF THE HITACHI-705 EVALUATED, FOREST, JC, DOUVILLE, P, Clinical Chemistry, 1983
  • ADAPTATION OF A COMMERCIALLY AVAILABLE KIT FOR THE MEASUREMENT OF SERUM MYOGLOBIN FOR THE SIMPLE AND QUICK MEASUREMENT OF MYOGLOBIN IN URINE, TALBOT, J, GAUVIN, R, DOUVILLE, P, Clinical Biochemistry, 1987, 10.1016/S0009-9120(87)80040-1
  • Relationship between plasma endothelin-1, HDL-C and systolic blood pressure in renal transplant recipients, Bergeron, J, Douville, P, Noel, R, Lachance, JG, Lariviere, R, Kigma, I, Houde, I, Lebel, M, Radeau, T, Atherosclerosis, 1997, 10.1016/S0021-9150(97)88880-6
  • Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial, Hercberg, S, Estaquio, C, Bertrais, S, Kegle, P, Bairati, I, Douville, P, Galan, P, Meyer, F, International Journal of Cancer, 2005, 10.1002/IJC.21058
  • Comparison of fasting and non-fasting lipid profiles in a large cohort of patients presenting at a community hospital, Douville, Pierre, Lagace, Mathieu, Collins, Charlene, Cartier, Louis-Jacques, Clinical Biochemistry, 2018, 10.1016/J.CLINBIOCHEM.2017.11.007
  • Relationships Between Serum IL-6, Tobacco Consumption, and the Occurrence of Second Primary Cancers in Head and Neck Cancer Patients, Meyer, F., Douville, P., Talbot, D., Cottin, S. Carrondo, Bairati, I., International Journal of Radiation Oncology Biology Physics, 2018, 10.1016/J.IJROBP.2017.12.116
  • Variability of High-Sensitivity Troponin T Concentrations in Emergency Settings Impact for the Diagnosis of Myocardial Infarction, Theriault, Sebastien, Douville, Pierre, American Journal of Clinical Pathology, 2018, 10.1093/AJCP/AQY025
  • MEASUREMENT OF SERUM PLACENTAL ALKALINE-PHOSPHATASE, TALBOT, J, DOUVILLE, P, VANHAUTE, B, Annales de Biologie Clinique, 1991
  • Problems with the estimation of urine protein by automated assays, Douville, P, Leclerc, P, Girouard, J, Dube, J, Clinical Biochemistry, 2005, 10.1016/J.CLINBIOCHEM.2004.12.010
  • STIMULATION OF RAT PITUITARY AND HYPOTHALAMIC CYCLIC-AMP CONCENTRATIONS BY PROSTAGLANDINS INVIVO, BERGERON, L, DOUVILLE, P, BARDEN, N, Clinical Research, 1975
  • A NEW RAPID IMMUNOINHIBITION PANCREATIC AMYLASE ASSAY - DIAGNOSTIC-VALUE FOR PANCREATITIS, DELACLOS, BF, BERGERON, J, LECLERC, P, DOUVILLE, P, FOREST, JC, NADEAU, L, TURCOTTE, GE, Clinical Biochemistry, 1994, 10.1016/0009-9120(94)90023-X
  • EVALUATION OF THE AVERAGE OF PATIENTS - APPLICATION TO ENDOCRINE ASSAYS, STRAUSS, JF, CEMBROWSKI, GS, DOUVILLE, P, Clinica Chimica Acta, 1987, 10.1016/0009-8981(87)90370-6
  • Functional tests for primary aldosteronism: Value of captopril suppression, Lebel, M, Douville, P, Racine, MC, Current Hypertension Reports, 2002, 10.1007/S11906-002-0014-5
  • Human epididymis protein 4 (HE4) and ovarian cancer prognosis, Bairati, Isabelle, Douville, Pierre, Bachvarov, Dimcho, Renaud, Marie-Claude, Plante, Marie, Gregoire, Jean, Tetu, Bernard, Trudel, Dominique, Gynecologic Oncology, 2012, 10.1016/J.YGYNO.2012.09.003
  • The Effect of Triglyceride Concentration on Attainment of Lipid Targets in Patients with Diabetes, Douville, Pierre, Lagace, Mathieu, Collins, Charlene, Cartier, Louis-Jacques, Canadian Journal of Diabetes, 2017, 10.1016/J.JCJD.2016.12.006
  • Predictive factors for sentinel lymph nodes and non-sentinel lymph nodes metastatic involvement: a database study of 1,041 melanoma patients, Claveau, Joel, Ouellet, Jean-Francois, Morin, Francis, Friede, Juan, Labonte, Sebastien, Gagne, Eric J., Douville, Pierre, Milot, Helene, Kibrite, Antoine, The American Journal of Surgery, 2016, 10.1016/J.AMJSURG.2015.05.016
  • Reversal of Severe and Refractory Humoral Hypercalcemia With 177Lu-Octreotate Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumor of the Pancreas, Mac-Way, Fabrice, Douville, Pierre, Couture, Felix, Beauregard, Jean-Mathieu, Iliuta, Ioan-Andrei, Clinical Nuclear Medicine, 2015, 10.1097/RLU.0000000000000862
  • Does salt loading alter results of postural stimulation test in subtyping patients with primary aldosteronism?, Douville, P., Agharazii, M., Plamondon, I., Lebel, M., Journal of Hypertension, 2006
  • Prediction and validation of the duration of hemodialysis sessions for the treatment of acute ethylene glycol poisoning, Agharazii, Mohsen, Douville, Pierre, Julien, Anne-Sophie, De Serres, Sacha A., Desmeules, Simon, Mac-Way, Fabrice, Begin, Yannick, Ghannoum, Marc, Lachance, Philippe, Iliuta, Ioan-Andrei, Kidney International, 2017, 10.1016/J.KINT.2017.02.018
  • VISCERAL PERCEPTION IN HEALTH AND FUNCTIONAL DYSPEPSIA - CROSSOVER STUDY OF GASTRIC DISTENSION WITH PLACEBO AND DOMPERIDONE, MORIN, A, DOUVILLE, P, PARE, P, BRADETTE, M, Digestive Diseases and Sciences, 1991, 10.1007/BF01300087
  • MATHEMATICAL OPTIMIZATION OF SERUM FLUORIDE MEASUREMENT BY KNOWN ADDITION WITH A SELECTIVE ELECTRODE, DOUVILLE, P, SENECAL, PE, Clinical Biochemistry, 1987, 10.1016/S0009-9120(87)80039-5
  • POTENTIAL USEFULNESS OF SERUM PRE-ALBUMIN IN TOTAL PARENTERAL-NUTRITION, BELANGER, L, LAPOINTE, R, TALBOT, J, DOUVILLE, P, Clinical Chemistry, 1982
  • Estimation of heparin leak into the systemic circulation after central venous catheter heparin lock, Desmeules, S, Douville, P, Lebel, M, Plamondon, I, Agharazii, M, Nephrology Dialysis Transplantation, 2005, 10.1093/NDT/GFH841
  • Nonfasting non-high-density lipoprotein cholesterol is adequate for lipid management in hemodialysis patients, Agharazii, M, Douville, P, Bergeron, J, Arcand-Bosse, JF, Desmeules, S, American Journal of Kidney Diseases, 2005, 10.1053/J.AJKD.2005.03.002
  • Serum Parathyroid Hormone and 25-Hydroxyvitamin D Concentrations Before and After Biliopancreatic Diversion, Gagnon, Claudia, Hould, Frederic-Simon, Marceau, Simon, Biertho, Laurent, Lebel, Stefane, Douville, Pierre, Julien, Anne-Sophie, Blais, Jean-Philippe, Tardio, Vanessa, Obesity Surgery, 2018, 10.1007/S11695-017-3101-Z
  • Prediction and validation of hemodialysis duration in acute methanol poisoning, Agharazii, Mohsen, Ghannoum, Marc, Douville, Pierre, Julien, Anne-Sophie, De Serres, Sacha A., Desmeules, Simon, Mac-Way, Fabrice, Lachance, Philippe, Kidney International, 2015, 10.1038/KI.2015.232
  • ADULT CELIAC SPRUE - CHANGES IN THE PATTERN OF CLINICAL RECOGNITION, LAGACE, R, CARON, D, DOUVILLE, P, PARE, P, Journal of Clinical Gastroenterology, 1988, 10.1097/00004836-198808000-00010
  • A prospective study of the insulin-like growth factor axis in relation with prostate cancer in the SU.VI.MAX trial, Hercberg, S, Czernichow, S, Bertrais, S, Kegle, P, Bairati, I, Douville, P, Galan, P, Meyer, F, Cancer Epidemiology Biomarkers & Prevention, 2005, 10.1158/1055-9965.EPI-05-0303
  • PERFORMANCE OF THE NEW HITACHI-705, FOREST, JC, DOUVILLE, P, Clinical Chemistry, 1982
  • Active renin mass concentration to determine aldosterone-to-renin ratio in screening for primary aldosteronism, Lebel, Marcel, Douville, Pierre, Corbin, Francois, International Journal of Nephrology and Renovascular Disease, 2011, 10.2147/IJNRD.S22245
  • PERFORMANCE OF GLUCOSE MEASUREMENTS WITH REFLECTOMETERS OUTSIDE THE LABORATORY IN RELATION TO THE FREQUENCE OF UTILIZATION, GAUVIN, R, ROUSSEAU, F, DOUVILLE, P, TALBOT, J, FOREST, JC, Clinical Biochemistry, 1987, 10.1016/S0009-9120(87)80026-7
  • DIAGNOSTIC-VALUE OF SEQUENTIAL READINGS WITH THE MINOLTA TRANS-CUTANEOUS BILIRUBINOMETER IN NORMAL AND LOW-BIRTHWEIGHT INFANTS, FOREST, JC, MASSON, M, DOUVILLE, P, Clinical Chemistry, 1983
  • Effect of terminal renal failure on the ratio of free to total prostate-specific antigen, Tiberi, M, Douville, P, Tumor Biology, 1998, 10.1159/000029981
  • SRD5A Polymorphisms and Biochemical Failure After Radical Prostatectomy, Levesque, Eric, Guillemette, Chantal, Girard, Hugo, Douville, Pierre, Bao, Bo-Ying, Huang, Shu-Pin, Fradet, Vincent, Fradet, Yves, Lacombe, Louis, Nadeau, Genevieve, Bellemare, Judith, Audet-Walsh, Etienne, European Urology, 2011, 10.1016/J.EURURO.2011.06.020
  • PROGNOSTIC IMPACT OF INHERITED GENETIC VARIATIONS IN SRD5A AND ANDROGEN INACTIVATING UGT2B GENES IN PROSTATE CANCER AFTER PROSTATECTOMY, Levesque, Eric, Guillemette, Chantal, Girard, Hugo, Douville, Pierre, Lacombe, Louis, Nadeau, Genevieve, Bellemare, Judith, Audet-Walsh, Etienne, Fradet, Yves, Journal of Urology, 2011, 10.1016/J.JURO.2011.02.2533
  • Active Vitamin D and Accelerated Progression of Aortic Stiffness in Hemodialysis Patients: A Longitudinal Observational Study, Agharazii, Mohsen, Lariviere, Richard, Desmeules, Simon, Douville, Pierre, Marquis, Karine, De Serres, Sacha A., Mac-Way, Fabrice, Fortier, Catherine, American Journal of Hypertension, 2014, 10.1093/AJH/HPU057
  • AN APPROACH TO THE USE OF CLINICAL-LIMITS FOR QUALITY-CONTROL, CEMBROWSKI, GS, DOUVILLE, P, Laboratory Medicine, 1989, 10.1093/LABMED/20.6.406

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