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Pierre Leclerc

Professeur titulaire

pierre.leclerc.4@ulaval.ca
Centre de recherche en reproduction, développement et santé intergénérationnelle
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Reproduction, génétique, périnatalité et développement

Domaines de recherche

  • Différences sexuelles dans les cellules, les tissus et les animaux
  • Autres médecine fondamentale et sciences de la vie
  • Signalisation intracellulaire, transduction des signaux, biologie des récepteurs et des membranes

Projets de recherche en cours

  • Réseau Québécois en Reproduction - Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2024-04-01 au 2030-03-31
  • Intercellular communication networks and luminal acidification in the post-testicular male reproductive tract - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2022-10-01 au 2027-09-30
  • Mitochondrial signaling plays an important role in the regulation of sperm motility and fertilizing ability - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2021-10-01 au 2026-09-30
  • Elucidating the intracellular mechanisms that regulate mammalian sperm fertilizing ability and motility - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2021-04-01 au 2026-03-31

Financements des 2 dernières années

  • Importance de la protéine STAT3 dans la spermiogenèse, l’intégrité et la motilité des spermatozoïdes - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2022-07-01 au 2023-06-30
  • Réseau Québécois en Reproduction (RQR) - Fonds de recherche du Québec - Nature et technologies, Université de Sherbrooke, Université Laval - Fonds internes, Université de Montréal, Université du Québec à Trois-Rivières, Institut national de recherche scientifique (INRS) - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2017-04-01 au 2023-03-31

Publications

  • Proteomic comparison of detergent-extracted sperm proteins from bulls with different fertility indexes, Sullivan, R., Leclerc, P., Fortier, M., Frenette, G., D'Amours, O., Reproduction, 2010, 10.1530/REP-09-0375
  • Distribution and localization of calmodulin-binding proteins in bull spermatozoa, Goupil, S., Leclerc, P., Biology of Reproduction, 2000, 10.1095/biolreprod62.6.1875
  • Use of phosphoproteomics to study tyrosine kinase activity in capacitating boar sperm: Kinase activity and capacitation, Leclerc, P., Lefièvre, L., Reyes-Moreno, C., Beaulieu, M., Dubé, C., Tardif, S., Bailey, J.L., Theriogenology, 2005, 10.1016/j.theriogenology.2004.09.034
  • Regulation of the human sperm tyrosine kinase c-yes. Activation by cyclic adenosine 3′,5′-monophosphate and inhibition by Ca2+, Goupil, S., Leclerc, P., Biology of Reproduction, 2002, 10.1095/biolreprod67.1.301
  • Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization, Gagnon, C., Leclerc, P., De Lamirande, E., Molecular Human Reproduction, 1997, 10.1093/molehr/3.3.175
  • Expression of Hsp60 and Grp78 in the human endometrium and oviduct, and their effect on sperm functions, Leclerc, P., Bailey, J.L., Lachance, C., Human Reproduction, 2007, 10.1093/humrep/dem242
  • Papaverine-sensitive phosphodiesterase activity is measured in bovine spermatozoa, Richard, F.J., Vigneault, C., Blondin, P., Sullivan, R., Leclerc, P., Aragon, J.P., Poulin, M.-P., Laroche, A., Guillemette, C., Hébert, A., Bergeron, A., Andrology, 2017, 10.1111/andr.12290
  • Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium, Maccalman, C.D., Blaschuk, O.W., Leclerc, P., Stephenson, M.D., Chen, G.T.C., Getsios, S., Developmental Dynamics, 1998, 10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I
  • Mediators of the JAK/STAT signaling pathway in human spermatozoa, Leclerc, P., Lachance, C., Biology of Reproduction, 2011, 10.1095/biolreprod.111.092379
  • Identification and localisation of SERCA 2 isoforms in mammalian sperm, Leclerc, P., Goupil, S., Dorval, V., Lawson, C., Molecular Human Reproduction, 2007, 10.1093/molehr/gam012
  • The Importance of Calcium in the Appearance of p32, a Boar Sperm Tyrosine Phosphoprotein, during In Vitro Capacitation, Bailey, J.L., Leclerc, P., Tardif, S., Dubé, C., Journal of Andrology, 2003, 10.1002/j.1939-4640.2003.tb02734.x
  • Problems with the estimation of urine protein by automated assays, Douville, P., Leclerc, P., Girouard, J., Dube, J., Clinical Biochemistry, 2005, 10.1016/j.clinbiochem.2004.12.010
  • Effect of heparin on the expression of calmodulin-binding proteins in bull spermatozoa, Chafouleas, J.G., Sirard, M.A., Lambert, R.D., Langlais, J., Leclerc, P., Journal of Reproduction and Fertility, 1989, 10.1530/jrf.0.0850615
  • Cyclic nucleotide phosphodiesterases in human spermatozoa and seminal fluid: Presence of an active PDE10A in human spermatozoa, Richard, F.J., Leclerc, P., Blondin, P., Goupil, S., Guillemette, C., Maréchal, L., Biochimica et Biophysica Acta - General Subjects, 2017, 10.1016/j.bbagen.2016.11.006
  • Leukemia inhibitory factor regulates differentiation of trophoblastlike BeWo cells through the activation of JAK/STAT and MAPK3/1 MAP kinase-signaling pathways, Reyes-Moreno, C., Lafond, J., Leclerc, P., Asselin, É., Bourassa, V., Leduc, K., Biology of Reproduction, 2012, 10.1095/biolreprod.111.094334
  • Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway, Kopf, G.S., Olds-Clarke, P., Pan, D., Connors, S.A., Leclerc, P., Bailey, J.L., Moore, G.D., Visconti, P.E., Development, 1995
  • Investigation of MYST4 histone acetyltransferase and its involvement in mammalian gametogenesis, Sirard, M.-A., Leclerc, P., Vigneault, C., Morin, G., McGraw, S., BMC Developmental Biology, 2007, 10.1186/1471-213X-7-123
  • Localization of Hsp60 and Grp78 in the human testis, epididymis and mature spermatozoa, Leclerc, P., Bailey, J.L., Sullivan, R., Thimon, V., Fortier, M., Lachance, C., International Journal of Andrology, 2010, 10.1111/j.1365-2605.2008.00948.x
  • The proacrosin binding protein, sp32, is tyrosine phosphorylated during capacitation of pig sperm, Bailey, J.L., Reyes-Moreno, C., Baba, T., Leclerc, P., Dubé, C., Journal of Andrology, 2005, 10.2164/jandrol.04163
  • Identification of the proteins present in the bull sperm cytosolic fraction enriched in tyrosine kinase activity: A proteomic approach, Leclerc, P., Faure, R.L., Lalancette, C., Proteomics, 2006, 10.1002/pmic.200500578
  • Erratum: Decreased binding of calmodulin to bull sperm proteins during heparin-induced capacitation (Biol. Reprod. 1990; 42: 483-489), Lambert, R.D., Chefouleas, J.G., Sirard, M.-A., Leclerc, P., Biology of Reproduction, 1990
  • Increased activity of the human sperm tyrosine kinase SRC by the cAMP-dependent pathway in the presence of calcium, Leclerc, P., Goupil, S., Lawson, C., Biology of Reproduction, 2008, 10.1095/biolreprod.108.070367
  • Membranous and structural damage that occur during cryopreservation of human sperm may be time-related events, Sullivan, R., Leclerc, P., Légaré, C., Desrosiers, P., Fertility and Sterility, 2006, 10.1016/j.fertnstert.2005.11.046
  • Developmental expression of the fragile X-related 1 proteins in mouse testis: Association with microtubule elements, Khandjian, E.W., Leclerc, P., Mazroui, R., Huot, M.-E., Human Molecular Genetics, 2001, 10.1093/hmg/10.24.2803
  • Regulation of the phosphotyrosine content of human sperm proteins by intracellular Ca2+: Role of Ca2+-adenosine triphosphatases, Leclerc, P., Dufour, M., Dorval, V., Biology of Reproduction, 2002, 10.1095/biolreprod.102.004127
  • p95, the major phosphotyrosine-containing protein in mouse spermatozoa, is a hexokinase with unique properties, Kopf, G.S., Leclerc, P., Visconti, P., Kalab, P., Journal of Biological Chemistry, 1994
  • Semen characteristics of genetically identical quadruplet bulls, Sullivan, R., Leclerc, P., Bailey, J.L., Twagiramungu, H., Kroetsch, T., Bilodeau, J.-F., Masseau, I., Lessard, C., Theriogenology, 2003, 10.1016/S0093-691X(02)01256-6
  • Decreased binding of calmodulin to bull sperm proteins during heparin-induced capacitation, Lambert, R.D., Chafouleas, J.G., Sirard, M.-A., Leclerc, P., Biology of Reproduction, 1990, 10.1095/biolreprod42.3.483
  • Identification and localization of the cyclic nucleotide phosphodiesterase 10A in bovine testis and mature spermatozoa, Leclerc, P., Richard, F.J., Tremblay, M.-È., Hajj, H.E., Maréchal, L., Goupil, S., PLoS ONE, 2016, 10.1371/journal.pone.0161035
  • Interaction between Ca2+, cyclic 3',5' adenosine monophosphate, the superoxide anion, and tyrosine phosphorylation pathways in the regulation of human sperm capacitation, Gagnon, C., De Lamirande, E., Leclerc, P., Journal of Andrology, 1998
  • Localization of the chaperone proteins GRP78 and HSP60 on the luminal surface of bovine oviduct epithelial cells and their association with spermatozoa, Leclerc, P., Sirard, M.-A., Bailey, J.L., Massicotte, L., Lachance, C., Reyes-Moreno, C., Boilard, M., Biology of Reproduction, 2004, 10.1095/biolreprod.103.026849
  • Cyclic adenosine 3',5'monophosphate-dependent regulation of protein tyrosine phosphorylation in relation to human sperm capacitation and motility, Gagnon, C., De Lamirande, E., Leclerc, P., Biology of Reproduction, 1996, 10.1095/biolreprod55.3.684
  • Phosphorylation of triton X-100 soluble and insoluble protein substrates in a demembranated/reactivated human sperm model, Gagnon, C., Leclerc, P., Molecular Reproduction and Development, 1996, 10.1002/(SICI)1098-2795(199606)44:2<200::AID-MRD9>3.0.CO;2-R
  • Bull testicular haploid germ cells express a messenger encoding for a truncated form of the protein tyrosine kinase HCK, Leclerc, P., Faure, R.L., Bordeleau, L.-J., Lalancette, C., Molecular Reproduction and Development, 2006, 10.1002/mrd.20422
  • Regulation of protein-tyrosine phosphorylation and human sperm capacitation by reactive oxygen derivatives, Gagnon, C., De Lamirande, E., Leclerc, P., Free Radical Biology and Medicine, 1997, 10.1016/S0891-5849(96)00379-6
  • Implication of calmodulin-dependent phosphodiesterase type 1 during bovine sperm capacitation, Bailey, J.L., Cormier, N., Leclerc, P., Fournier, V., Journal of Andrology, 2003
  • Infertility in a beef bull due to a failure in the capacitation process, Palmer, C., Leclerc, P., Sullivan, R., D'Amours, O., Siqueira, L.G., Lessard, C., Theriogenology, 2011, 10.1016/j.theriogenology.2011.04.020
  • Characterization of an 80-kilodalton bull sperm protein identified as PH-20, Leclerc, P., Leblanc, V., Dorval, V., Lalancette, C., Biology of Reproduction, 2001, 10.1095/biolreprod65.2.628
  • Cryopreservation affects bovine sperm intracellular parameters associated with capacitation and acrosome exocytosis, Leclerc, P., Bailey, J.L., Pons-Rejraji, H., Reproduction, Fertility and Development, 2009, 10.1071/RD07170
  • Decrease in calmodulin concentrations during heparin-induced capacitation in bovine spermatozoa, Lambert, R.D., Chafouleas, J.G., Sirard, M.A., Leclerc, P., Journal of Reproduction and Fertility, 1992, 10.1530/jrf.0.0940023
  • Role of protein tyrosine phosphorylation in the thapsigargin-induced intracellular Ca2+ store depletion during human sperm acrosome reaction, Leclerc, P., Dufour, M., Dorval, V., Molecular Human Reproduction, 2003, 10.1093/molehr/gag017
  • Direct effect of macrophage migration inhibitory factor on sperm function: possible involvement in endometriosis-associated infertility, Akoum, A., Metz, C.N., Leclerc, P., Carli, C., Fertility and Sterility, 2007, 10.1016/j.fertnstert.2007.04.002
  • Recombinant human oviductin regulates protein tyrosine phosphorylation and acrosome reaction, Kan, F.W.K., Leclerc, P., Reid, R.L., Jia, Z., Yang, X., Zhao, Y., Reproduction, 2016, 10.1530/REP-16-0177
  • Estrogen sulfotransferase is highly expressed along the bovine epididymis and is secreted into the intraluminal environment, Sullivan, R., D'Amours, O., Leclerc, P., Frenette, G., Journal of Andrology, 2009, 10.2164/jandrol.108.006668
  • SPAM1 isoforms from two tissue origins are differentially localized within ejaculated bull sperm membranes and have different roles during fertilization., Leclerc, P., Robert, C., Laflamme, I., Sullivan, R., Morin, G., Biology of reproduction, 2010, 10.1095/biolreprod.109.079582
  • Binder of sperm 1 and epididymal sperm binding protein 1 are associated with different bull sperm subpopulations, Leclerc, P., Sullivan, R., Blondin, P., Frenette, G., Bordeleau, L.-J., D'Amours, O., Reproduction, 2012, 10.1530/REP-11-0392
  • Stattic V, a STAT3 inhibitor, affects human spermatozoa through regulation of mitochondrial activity, Leclerc, P., Goupil, S., Lachance, C., Journal of Cellular Physiology, 2013, 10.1002/jcp.24215
  • Induction of human sperm capacitation and protein tyrosine phosphorylation by endometrial cells and interleukin-6, Leclerc, P., Akoum, A., Laflamme, J., Molecular Human Reproduction, 2005, 10.1093/molehr/gah142
  • Developmental expression of Src-related tyrosine kinases in the mouse testis, Leclerc, P., Bordeleau, L.-J., Trasler, J.M., La Salle, S., Goupil, S., Journal of Andrology, 2011, 10.2164/jandrol.110.010462
  • SPAM1 and PH-20 are two gene products expressed in bovine testis and present in sperm, Leclerc, P., Saindon, A.-A., Reproduction, 2018, 10.1530/REP-18-0185
  • Evidence for the role of heterotrimeric guanine nucleotide-binding regulatory proteins in the regulation of the mouse sperm adenylyl cyclase by the egg's zona pellucida, Kopf, G.S., Leclerc, P., Journal of Andrology, 1999
  • Inhibitors of phosphoinositide 3-kinase, LY294002 and wortmannin, affect sperm capacitation and associated phosphorylation of proteins differently: Ca2+-dependent divergences, Gagnon, C., Leclerc, P., De Lamirande, E., Nauc, V., Journal of Andrology, 2004, 10.1002/j.1939-4640.2004.tb02828.x
  • Novel technical strategies to optimize cryopreservation of goat semen using cholesterol-loaded cyclodextrin, Bailey, J.L., Leclerc, P., Salmon, V.M., Cryobiology, 2017, 10.1016/j.cryobiol.2016.12.010
  • In vitro fertilization of bovine oocytes matured in vivo and collected at laparoscopy, Bedoya, M., Ménard, D.P., Leclerc, P., Rioux, J.E., Béland, R., Bernard, C., Sirard, M.a., Lambert, R.D., Theriogenology, 1986, 10.1016/0093-691X(86)90188-3
  • Cytogenetic study of parthenogenetically activated bovine oocytes matured in vivo and in vitro, Jacques, P., Lambert, R.D., Leclerc, P., Greve, T., Sirard, M.‐A., Xu, K.P., King, W.A., Gamete Research, 1988, 10.1002/mrd.1120200303
  • The immobilization of human spermatozoa by STAT3 inhibitory compound V results from an excessive intracellular amount of reactive oxygen species, Leclerc, P., Tremblay, R.R., Goupil, S., Lachance, C., Andrology, 2016, 10.1111/andr.12123
  • Mouse sperm adenylyl cyclase: General properties and regulation by the zona pellucida, Kopf, G.S., Leclerc, P., Biology of Reproduction, 1995, 10.1095/biolreprod52.6.1227
  • Cholesterol-loaded cyclodextrin increases the cholesterol content of goat sperm to improve cold and osmotic resistance and maintain sperm function after cryopreservation, Bailey, J.L., Leclerc, P., Salmon, V.M., Biology of Reproduction, 2016, 10.1095/biolreprod.115.128553
  • Study on the role of calmodulin in sperm function through the enrichment and identification of calmodulin-binding proteins in bovine ejaculated spermatozoa, Saindon, A.-A., Ruiz, J., Clark, M.-È., Lavoie-Ouellet, C., Rioux, J.-F., Goupil, S., Leclerc, P., Journal of Cellular Physiology, 2020, 10.1002/jcp.29421
  • Calreticulin Affects β-Catenin-associated Pathways, Opas, M., Michalak, M., Blaschuk, O., Symonds, J.M., Dziak, E., Leclerc, P., Szewczenko-Pawlikowski, M., Fadel, M.P., Journal of Biological Chemistry, 2001, 10.1074/jbc.M101676200
  • Epididymosomes transfer epididymal sperm binding protein 1 (ELSPBP1) to dead spermatozoa during epididymal transit in bovine, Sullivan, R., Blondin, P., Leclerc, P., Allard, N., Bordeleau, L.-J., Frenette, G., D'Amours, O., Biology of Reproduction, 2012, 10.1095/biolreprod.112.100990 1-11
  • Dr Claude Gagnon., Robaire, B., Lefievre, L., Leclerc, P., de Lamirande, E., O'Flaherty, C., Journal of andrology, 2012, 10.2164/jandrol.112.017426
  • Identification of the bull sperm p80 protein as a PH-20 ortholog and its modification during the epididymal transit, Leclerc, P., Sullivan, R., Lalancette, C., Morin, G., Molecular Reproduction and Development, 2005, 10.1002/mrd.20308
  • Cryopreservation alters the levels of the bull sperm surface protein P25b, Sullivan, R., Baileys, J.A.N.I.C.E.L., Leclerc, P., Parent, S., Lessard, C., Journal of Andrology, 2000, 10.1002/j.1939-4640.2000.tb02138.x
  • Modulation of bovine sperm signalling pathways: Correlation between intracellular parameters and sperm capacitation and acrosome exocytosis, Leclerc, P., Bailey, J.L., Pons-Rejraji, H., Reproduction, Fertility and Development, 2009, 10.1071/RD07169
  • Expression of hck-tr, a truncated form of the src-related tyrosine kinase hck, in bovine spermatozoa and testis, Leclerc, P., Bordeleau, L.-J., Molecular Reproduction and Development, 2008, 10.1002/mrd.20814
  • The protein phosphatase with EF-hand domain 1 is a calmodulin-binding protein that interacts with proteins involved in sperm capacitation, binding to the zona pellucida, and motility, Leclerc, P., Saindon, A.-A., Ruiz, J., Clark, M.-È., Lavoie-Ouellet, C., Molecular Reproduction and Development, 2021, 10.1002/mrd.23467
  • Implication of the human binder of SPerm Homolog 1 (BSPH1) protein in capacitation, Manjunath, P., Fan, J., Leclerc, P., Lachance, C., Thérien, I., Plante, G., Molecular Human Reproduction, 2014, 10.1093/molehr/gau006
  • Cholesterol-loaded cyclodextrin improves ram sperm cryoresistance in skim milk-extender, Bailey, J.L., Leclerc, P., Demers-Caron, V., Castonguay, F., Salmon, V.M., Animal Reproduction Science, 2017, 10.1016/j.anireprosci.2016.11.011

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/04
  • Samira Kanouni - Maîtrise avec mémoire - En cours
  • Tania Laperrière - Maîtrise avec mémoire - En cours
  • Edith Gosselin - Maîtrise avec mémoire - En cours
  • Jolianne Bernier - Maîtrise avec mémoire - En cours
  • Rohit Kumar Deshmukh - Doctorat - En cours
  • Camille Lavoie-Ouellet - Maîtrise avec mémoire - 2021/05
  • Ariane Lapointe-Belleau - Maîtrise avec mémoire - 2024/05
  • Sandrine Delisle - Maîtrise avec mémoire - 2024/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Médecine moléculaire

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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