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Roger C. Levesque

Professeur titulaire

rclevesq@ibis.ulaval.ca
Institut de biologie intégrative et des systèmes
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Bioinformatique / données massives (big data)
  • Immunologie-infectiologie
  • Santé cardiovasculaire, respiratoire et métabolisme

Domaines de recherche

  • Génomique
  • Métagénomique environnementale
  • Algorithmes et informatique appliquée à la génomique
  • Microbiologie de l'environnement (y compris la microbiologie de l'air)
  • Microbiologie médicale, n.c.a.
  • Biogéochimie et microbiologie des sols

Projets de recherche en cours

  • Phycotoxins in the Arctic: an emerging climate change risk (PHATE) - Secrétariat des programmes interorganismes à l’intention des établissements - Fonds Nouvelle frontières en recherche - Volet Transformation, University of New Brunswick, co-chercheur - 2025-03-31 au 2029-03-30
  • MicroPaint: a pipeline for Meta and Genomics Real-Time Monitoring of Antibiotic Resistance Pathogens - Génome Québec - Solutions génomiques pour l’identification, la caractérisation et la surveillance de la résistance aux antimicrobiens et des pathogènes émergents, chercheur principal - 2023-10-01 au 2026-09-30
  • MICPathoScan-Ticks: Microbiome Pathogen Scanning Tick Species and Multiplex Diagnostics of Human Pathogens - Génome Québec - Programme d’intégration de la génomique, chercheur principal - 2023-10-01 au 2025-11-22
  • RosHAB: Rapid on-site detection of harmful algal blooms - Génome Québec, Génome Canada - Programme de partenariats pour les applications de la génomique (PPAG), Institut national de la recherche scientifique, Université du Québec - INRS, co-chercheur - 2022-10-01 au 2025-09-30

Financements des 2 dernières années

  • An evidence-based preclinical framework for the development of antimicrobial therapeutics in cystic fibrosis (PIPE-CF) - Cystic Fibrosis Trust, University of Liverpool, co-chercheur - 2021-10-01 au 2024-03-31
  • A Smart Surveillance Strategy for Carbapenem-resistant Pseudomonas aeruginosa - SAMPAN - Instituts de recherche en santé du Canada - Joint Programming Initiative on Antimicrobial Resistance JPIAMR, Université Érasme de Rotterdam, co-chercheur - 2019-10-01 au 2024-03-01
  • SENTINEL : Stopping Enteric Illnesses Early - Activité 1 - Génome Québec, Génome Canada - Programme de partenariats pour les applications de la génomique (PPAG), University of Guelph, co-chercheur - 2020-07-01 au 2023-06-30
  • SENTINEL : Stopping Enteric Illnesses Early - Activité 3 - Génome Canada, Génome Québec - Programme de partenariats pour les applications de la génomique (PPAG), University of Guelph, co-chercheur - 2020-07-01 au 2023-06-30
  • SENTINEL : Stopping Enteric Illnesses Early - Génome Canada, Ministère de l'agriculture, des pêcheries et de l'alimentation, Génome Québec - Programme de partenariats pour les applications de la génomique (PPAG), University of Guelph, co-chercheur - 2020-07-01 au 2023-06-30

Publications

  • Defined oligonucleotide tag pools and pcr screening in signature-tagged mutagenesis of essential genes from bacteria, Levesque, R.C., Sanschagrin, F., Lehoux, D.E., BioTechniques, 1999, 10.2144/99263st02
  • Antimicrobial resistance genes in enterotoxigenic Escherichia coli O149: K91 isolates obtained over a 23-year period from pigs, Harel, J., Larivière, S., Masson, L., Brousseau, R., Levesque, R.C., Sanschagrin, F., Bekal, S., Fairbrother, J.M., Maynard, C., Antimicrobial Agents and Chemotherapy, 2003, 10.1128/AAC.47.10.3214-3221.2003
  • A Pan-Genomic Approach to Understand the Basis of Host Adaptation in Achromobacter., , Genome biology and evolution, 2017, 10.1093/gbe/evx061
  • Molecular cloning and DNA homology of plasmid-mediated β-lactamase genes, Jacoby, G.A., Medeiros, A.A., Levesque, R.C., MGG Molecular & General Genetics, 1987, 10.1007/BF00333581
  • Letter to the editor: 1H, 13C and 15N backbone resonance assignments for TEM-1, a 28.9 kDa β-lactamase from E. coli [19], Gagné, S.M., Makinen, M.W., Levesque, R.C., Sosa-Peinado, A., Savard, P.-Y., Journal of Biomolecular NMR, 2004, 10.1023/B:JNMR.0000032503.96942.68
  • Insights into the Structure of the Spruce Budworm (Choristoneura fumiferana) Genome, as Revealed by Molecular Cytogenetic Analyses and a High-Density Linkage Map., , G3 (Bethesda, Md.), 2018, 10.1534/g3.118.200263
  • ASD-GFP vectors for in vivo expression technology in Pseudomonas aeruginosa and other gram-negative bacteria, Levesque, R.C., Hoang, T., Sanschagrin, F., Mahan, M.J., Schweizer, H.P., Handfield, M., BioTechniques, 1998, 10.2144/98242st02
  • A peptide inhibitor of MurA UDP-N-acetylglucosamine enolpyruvyl transferase: The first committed step in peptidoglycan biosynthesis, Levesque, R.C., Sanschagrin, F., Molina-López, J., Peptides, 2006, 10.1016/j.peptides.2006.08.023
  • Diabetes: A major co-morbidity of cystic fibrosis, Rabasa-Lhoret, R., Chiasson, J.L., Levesque, R., Lavoie, A., Jeanneret, A., Gauthier, L., Berthiaume, Y., Potvin, S., Costa, M., Diabetes and Metabolism, 2005, 10.1016/S1262-3636(07)70189-1
  • Cloning, over-expression and purification of Pseudomonas aeruginosa murC encoding uridine diphosphate N-acetylmuramate: L-alanine ligase, Levesque, R.C., Darveau, A., Lamoureux, J., Sanschagrin, F., El Zoeiby, A., FEMS Microbiology Letters, 2000, 10.1016/S0378-1097(00)00003-3
  • Preface, Levesque, R.C., Ramos, J.-L., Pseudomonas, 2006, 10.1007/0-387-28881-3
  • Genomics of Banchine Ichnoviruses: Insights into their relationship to Bracoviruses and Campoplegine Ichnoviruses, Levesque, R.C., Maaroufi, H., Drezen, J.-M., Volkoff, A.-N., Nisole, A., Béliveau, C., Lapointe, R., Stoltz, D., Cusson, M., Parasitoid Viruses: Symbionts and Pathogens, 2012, 10.1016/B978-0-12-384858-1.00006-0
  • Reservoirs of resistance: polymyxin resistance in veterinary-associated companion animal isolates of Pseudomonas aeruginosa., , The Veterinary record, 2019, 10.1136/vr.105075
  • Comparative study of the beta-lactamase activity found in Achromobacter., Pechère, J.C., Letarte, R., Levesque, R., Canadian journal of microbiology, 1983, 10.1139/m83-133
  • Parallel solid synthesis of inhibitors of the essential cell division FtsZ enzyme as a new potential class of antibacterials, Levesque, R.C., Voyer, N., Sanschagrin, F., Beaumont, M., Paradis-Bleau, C., Bioorganic and Medicinal Chemistry, 2007, 10.1016/j.bmc.2006.11.015
  • Development of gene probes and evolutionary relationships of the PSE-4 bla gene to plasmid-mediated β-lactamases of gram-negative bacteria, Levesque, R.C., Mercier, J., Huot, A., Boissinot, M., Molecular and Cellular Probes, 1989, 10.1016/0890-8508(89)90028-5
  • Proteomic, microarray, and signature-tagged mutagenesis analyses of anaerobic Pseudomonas aeruginosa at pH 6.5, likely representing chronic, late-stage cystic fibrosis airway conditions, Hassett, D.J., Hunt, D.F., Kjelleberg, S., Webb, J., Barraud, N., Lieberman, M.A., Rowe, J.J., Limbach, P.A., Lau, G.W., Hwang, S.-H., Schurr, J., Brinkman, F.S.L., Fedynak, A., Levesque, R.C., Potvin, E., Kukavica-Ibrulj, I., Vazquez, G., Sauer, K., Schurr, M.J., Platt, M.D., Journal of Bacteriology, 2008, 10.1128/JB.01683-07
  • Detection of the pathogenic parasite Toxoplasma gondii by specific amplification of ribosomal sequences using comultiplex polymerase chain reaction, Levesque, R.C., Mercier, J., Gagnon, S., Morency, M.-J., Dubois, D., Guay, J.-M., Journal of Clinical Microbiology, 1993, 10.1128/jcm.31.2.203-207.1993
  • Draft genome sequence of triclosan-resistant cystic fibrosis isolate Achromobacter xylosoxidans CF304, Levesque, R.C., Nguyen, D., Kukavica-Ibrulj, I., Freschi, L., Jeukens, J., Genome Announcements, 2015, 10.1128/genomeA.00865-15
  • In vitro reconstruction of the biosynthetic pathway of peptidoglycan cytoplasmic precursor in Pseudomonas aeruginosa, Levesque, R.C., Garnier, A., Havugimana, P.C., Sanschagrin, F., El Zoeiby, A., FEMS Microbiology Letters, 2001, 10.1016/S0378-1097(01)00268-3
  • Comparative analysis of mitochondrial genomes of geographic variants of the gypsy moth, Lymantria dispar, reveals a previously undescribed genotypic entity., , Scientific reports, 2017, 10.1038/s41598-017-14530-6
  • Pseudomonas aeruginosa MurE amide ligase: Enzyme kinetics and peptide inhibitor, Levesque, R.C., Bugg, T.D., Roper, D.I., Dowson, C., Blewett, A., Clarke, T., Maaroufi, H., Sanschagrin, F., Lloyd, A., Paradis-Bleau, C., Biochemical Journal, 2009, 10.1042/BJ20081395
  • A plasmid-mediated cepbalosporinase from achromobacter species, Pechere, J.-C., Letarte, R., Levesque, R., Roy, P.H., Journal of Infectious Diseases, 1982, 10.1093/infdis/145.2.753
  • Genomic characterisation of environmental Pseudomonas aeruginosa isolated from dental unit waterlines revealed the insertion sequence ISPa11 as a chaotropic element., , FEMS microbiology ecology, 2017, 10.1093/femsec/fix106
  • Discovering essential and infection-related genes, Levesque, R.C., Sanschagrin, F., Lehoux, D.E., Current Opinion in Microbiology, 2001, 10.1016/S1369-5274(00)00244-7
  • Complete genome sequences of three Pseudomonas aeruginosa isolates with phenotypes of polymyxin B adaptation and inducible resistance, Levesque, R.C., Hancock, R.W., Mendes, C.M.F., Kukavica-Ibrulj, I., Laroche, J., Fernandez, L., Boyle, B., Journal of Bacteriology, 2012, 10.1128/JB.06246-11
  • Primary structure of OXA-3 and phylogeny of oxacillin-hydrolyzing class D β-lactamases, Levesque, R.C., Couture, F., Sanschagrin, F., Antimicrobial Agents and Chemotherapy, 1995, 10.1128/AAC.39.4.887
  • Characterization of the blaCARB-3 gene encoding the carbenicillinase-3 β-lactamase of Pseudomonas aeruginosa, Levesque, R.C., Dufresne, J., Lachapelle, J., Gene, 1991, 10.1016/0378-1119(91)90530-O
  • Broad-host-range mobilizable suicide vectors for promoter trapping in gram-negative bacteria, Antoun, H., Broughton, W.J., Perret, X., Levesque, R.C., Izallalen, M., BioTechniques, 2002, 10.2144/02335st04
  • An Organ System-Based Synopsis of Pseudomonas aeruginosa Virulence., , Virulence, 2021, 10.1080/21505594.2021.1926408
  • Peptide inhibitors of the essential cell division protein FtsA, Levesque, R.C., Sanschagrin, F., Paradis-Bleau, C., Protein Engineering, Design and Selection, 2005, 10.1093/protein/gzi008
  • Identification of in vivo essential genes from Pseudomonas aeruginosa by PCR-based signature-tagged mutagenesis, Levesque, R.C., Sanschagrin, F., Lehoux, D.E., FEMS Microbiology Letters, 2002, 10.1016/S0378-1097(02)00597-9
  • PCR screening in signature-tagged mutagenesis of essential genes., Levesque, R.C., Lehoux, D.E., Methods in molecular biology (Clifton, N.J.), 2002, 10.1385/1-59259-177-9:225
  • Erratum: 1H, 13C, and 15N backbone resonance assignments for PSE-4, a 29.5 kDa class A β-lactamase from Pseudomonas aeruginosa (Journal of Biomolecular NMR 10.1007/s10858-005-5343-7), Gagné, S.M., Levesque, R.C., Morin, S., Journal of Biomolecular NMR, 2006, 10.1007/s10858-006-9069-y
  • Draft genomes of 12 host-adapted and environmental isolates of Pseudomonas aeruginosa and their positions in the core genome phylogeny, Tucker, N.P., Levesque, R., Hoskisson, P.A., Crossman, L., Caim, S., Kukavica-Ibrulj, I., Boyle, B., Jeukens, J., Sangal, V., Ford, A., Stewart, L., Pathogens and Disease, 2014, 10.1111/2049-632X.12107
  • Decreased outer membrane permeability in imipenem-resistant mutants of Pseudomonas aeruginosa, Nikaido, H., Levesque, R.C., Dufresne, J., Trias, J., Antimicrobial Agents and Chemotherapy, 1989, 10.1128/aac.33.8.1202
  • AnCo3, a new member of the emerging family of phage-like plasmids, Goodridge, L., Levesque, R., Kukavica-Ibrulj, I., Edmond Rheault, J.-G., Freschi, L., Jeukens, J., Colavecchio, A., Genome Announcements, 2017, 10.1128/genomeA.00110-17
  • Characterization of a PSE-4 mutant with different properties in relation to penicillanic acid sulfones: Importance of residues 216 to 218 in class A β-lactamases, Levesque, R.C., Palzkill, T., Voyer, N., Sanschagrin, F., Thériault, E., Sabbagh, Y., Antimicrobial Agents and Chemotherapy, 1998, 10.1128/aac.42.9.2319
  • Increasing genomic diversity and evidence of constrained lifestyle evolution due to insertion sequences in Aeromonas salmonicida., , BMC genomics, 2016, 10.1186/s12864-016-2381-3
  • Prophage induction reduces Shiga toxin producing Escherichia coli (STEC) and Salmonella enterica on tomatoes and spinach: A model study, Goodridge, L.D., Bisha, B., Coleman, S.M., Chandler, J.C., Bekal, S., Kukavica-Ibrulj, I., Levesque, R.C., Emond-Rheault, J.-G., Freschi, L., Jeukens, J., Colavecchio, A., Cadieux, B., Food Control, 2018, 10.1016/j.foodcont.2018.02.001
  • In vivo functional genomics of Pseudomonas aeruginosa for high-throughput screening of new virulence factors and antibacterial targets, Levesque, R.C., Lau, G.W., Sanschagrin, F., Richard, K.L., Kukavica-Ibrulj, I., Lehoux, D.E., Potvin, E., Environmental Microbiology, 2003, 10.1046/j.1462-2920.2003.00542.x
  • Homology between the genes of octopine catabolism of Rhizobium meliloti A3 and corresponding genes from the Ti plasmid, Dion, P., Kondorosi, A., Levesque, R.C., Beaulieu, C., Bergeron, J., Canadian Journal of Microbiology, 1993, 10.1139/m93-158
  • Two's company, three's a crowd: new insights on spruce budworm species boundaries using genotyping-by-sequencing in an integrative species assessment (Lepidoptera: Tortricidae), Sperling, F.A.H., Cusson, M., LÉVESQUE, R.C., Boyle, B., Lumley, L.M., Muirhead, K., Blackburn, G.S., Brunet, B.M.T., Systematic Entomology, 2017, 10.1111/syen.12211
  • Comparative genomics of a drug-resistant Pseudomonas aeruginosa panel and the challenges of antimicrobial resistance prediction from genomes., , FEMS microbiology letters, 2017, 10.1093/femsle/fnx161
  • Molecular cloning, complete sequence of the small subunit ribosomal RNA coding region and phylogeny of Toxoplasma gondii, Gajadhar, A.A., Sogin, M.L., Levesque, R.C., Gagnon, S., Molecular and Biochemical Parasitology, 1993, 10.1016/0166-6851(93)90037-X
  • Comparative genomics of isolates of a Pseudomonas aeruginosa epidemic strain associated with chronic lung infections of cystic fibrosis patients, Levesque, R.C., Winstanley, C., Tucker, N.P., Fothergill, J.L., Charette, S.J., Aaron, S.D., Ouellet, M.M., Kukavica-Ibrulj, I., Boyle, B., Jeukens, J., PLoS ONE, 2014, 10.1371/journal.pone.0087611
  • Novel anionic cecropins from the spruce budworm feature a poly-L-aspartic acid C-terminus, Levesque, R.C., Cusson, M., Maaroufi, H., bioRxiv, 2018, 10.1101/307702
  • For the Safety of Fresh Produce: Regulatory Considerations for Canada on the Use of Whole Genome Sequencing to Subtype Salmonella, Joly, Y., Levesque, R.C., Goodridge, L., Farber, J., Song, L., Dalpé, G., Ngueng Feze, I., Frontiers in Sustainable Food Systems, 2018, 10.3389/fsufs.2018.00021
  • Molecular structure and interrelationships of multiresistance β-lactamase transposons, Jacoby, G.A., Levesque, R.C., Plasmid, 1988, 10.1016/0147-619X(88)90059-5
  • Identification of Pseudomonas aeruginosa FtsZ peptide inhibitors as a tool for development of novel antimicrobials [8], Levesque, R.C., Sanschagrin, F., Paradis-Bleau, C., Journal of Antimicrobial Chemotherapy, 2004
  • Signature-tagged mutagenesis, Levesque, R.C., Kukavica-Ibrulj, I., Methods in Molecular Biology, 2014, 10.1007/978-1-4939-0473-0_41
  • A needle in a haystack: a multigene TaqMan assay for the detection of Asian gypsy moths in bulk pheromone trap samples, Cusson, M., Hamelin, R.C., Levesque, R.C., Lamarche, J., Zahiri, R., Djoumad, A., Nisole, A., Stewart, D., Biological Invasions, 2019, 10.1007/s10530-019-01943-9
  • Site-saturation mutagenesis and three-dimensional modelling of rob-1 define a substrate binding role of ser 130 in class a β-lactamases, Levesque, R.C., Knox, J.R., Billings, E., Juteau, J.-M., Protein Engineering, Design and Selection, 1992, 10.1093/protein/5.7.693
  • Gene-Gene Interactions Dictate Ciprofloxacin Resistance in Pseudomonas aeruginosa and Facilitate Prediction of Resistance Phenotype from Genome Sequence Data., , Antimicrobial agents and chemotherapy, 2021, 10.1128/aac.02696-20
  • Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa., , Frontiers in chemistry, 2020, 10.3389/fchem.2020.00204
  • Functional annotation of the ophiostoma novo-ulmi genome: Insights into the phytopathogenicity of the fungal agent of Dutch elm disease, Bernier, L., Levesque, R.C., Laroche, J., Henrissat, B., Nigg, M., Jacobi, V., Bouvet, G.F., Dufour, J., Comeau, A.M., Genome Biology and Evolution, 2015, 10.1093/gbe/evu281
  • Complete genome sequence of multidrug-resistant Enterobacter roggenkampii 0-E, Roger C. Levesque, Chantal Brisson, Jimmy Bernier, Vani Mohit, Laure Cockenpot, Irena Kukavica-Ibrulj, Jeff Gauthier, Microbiology Resource Announcements, 2024, 10.1128/mra.01149-23
  • Cloning of SHV-2, OHIO-1, and OXA-6 β-lactamases and cloning and sequencing of SHV-1 β-lactamase, Levesque, R.C., Mercier, J., Antimicrobial Agents and Chemotherapy, 1990, 10.1128/AAC.34.8.1577
  • Application of a High-Throughput Targeted Sequence AmpliSeq Procedure to Assess the Presence and Variants of Virulence Genes in Salmonella, Dele Ogunremi, Lawrence D. Goodridge, Roger C. Levesque, Jérémie Hamel, Hongsheng Huang, Ruimin Gao, Microorganisms, 2022, 10.3390/microorganisms10020369
  • The biology of Mur ligases as an antibacterial target, Paradis-Bleau, C., Levesque, R.C., Kouidmi, I., Molecular Microbiology, 2014, 10.1111/mmi.12758
  • In vivo-induced genes in Pseudomonas aeruginosa, Levesque, R.C., Woods, D.E., Mahan, M.J., Sanschagrin, F., Lehoux, D.E., Handfield, M., Infection and Immunity, 2000, 10.1128/IAI.68.4.2359-2362.2000
  • Structural and functional characterization of tnpI, a recombinase locus in Tn21 and related β-lactamase transposons, Levesque, R.C., Boissinot, M., Vezina, G., Lafond, M., Couture, F., Lachapelle, J., Mercier, J., Journal of Bacteriology, 1990, 10.1128/jb.172.7.3745-3757.1990
  • Physical mapping of 32 genetic markers on the Pseudomonas aeruginosa PAO1 chromosome, Levesque, R.C., Hancock, R.E.W., Lam, J.S., Schweizer, H., Siehnel, R., Foster, J., Lightfoot, J., Dewar, K., Morency, M.-J., Ouellet, C., Charlebois, I., Liao, X., Microbiology, 1996, 10.1099/13500872-142-1-79
  • Identification of novel pathogenicity genes by PCR signature-tagged mutagenesis and related technologies., Levesque, R.C., Potvin, E., Kukavica-Ibrulj, I., Sanschagrin, F., Lehoux, D.E., Methods in molecular biology (Clifton, N.J.), 2004, 10.1385/1-59259-763-7:289
  • Cell culture tracking by multivariate analysis of raw LCMS data, Garnier, A., Levesque, R.C., Bernier, A., Sanschagrin, F., Duchesne, C., Havugimana, P.C., Michaud, F.-T., Applied Biochemistry and Biotechnology, 2012, 10.1007/s12010-012-9661-4
  • Roles of amino acids 161 to 179 in the PSE-4 Ω loop in substrate specificity and in resistance to ceftazidime, Levesque, R.C., Palzkill, T., Sanschagrin, F., Therrien, C., Antimicrobial Agents and Chemotherapy, 1998, 10.1128/aac.42.10.2576
  • Combinatorial enzymatic assay for the screening of a new class of bacterial cell wall inhibitors, Levesque, R.C., Voyer, N., Sanschagrin, F., Dubuc, E., Beaumont, M., Zoeiby, A.E., Bioorganic and Medicinal Chemistry, 2003, 10.1016/S0968-0896(02)00447-9
  • Draft genome sequences of six Pseudomonas spp. and one Rheinheimera sp. isolated from oil sands process-affected water from Alberta, Canada, Roger C. Levesque, Shawn Lewenza, Irena Kukavica-Ibrulj, Tyson Bookout, Steven M. Shideler, Jeff Gauthier, Kira L. Goff, Microbiology Resource Announcements, 2023, 10.1128/MRA.00589-23
  • In vivo growth of Pseudomonas aeruginosa strains PAO1 and PA14 and the hypervirulent strain LESB58 in a rat model of chronic lung infection, Levesque, R.C., O'Toole, G.A., Sanschagrin, F., Winstanley, C., Paroni, M., Bragonzi, A., Kukavica-Ibrulj, I., Journal of Bacteriology, 2008, 10.1128/JB.01572-07
  • The flagellum of Pseudomonas aeruginosa is required for resistance to clearance by surfactant protein A, Lau, G.W., O'Toole, G.A., Levesque, R.C., McCormack, F.X., Zhang, S., PLoS ONE, 2007, 10.1371/journal.pone.0000564
  • A New Whole Genome Culture-Independent Diagnostic Test (WG-CIDT) for Rapid Detection of Salmonella in Lettuce., , Frontiers in microbiology, 2020, 10.3389/fmicb.2020.00602
  • Secondary structures and features of the 18S, 5.8S and 26S ribosomal RNAs from the Apicomplexan parasite Toxoplasma gondii, Levesque, R.C., Bourbeau, D., Gagnon, S., Gene, 1996, 10.1016/0378-1119(96)00215-6
  • Structure and function of the Mur enzymes: Development of novel inhibitors, Levesque, R.C., Sanschagrin, F., El Zoeiby, A., Molecular Microbiology, 2003, 10.1046/j.1365-2958.2003.03289.x
  • Major Release of 161 Whole-Genome Sequences from the International Pseudomonas Consortium Database., , Microbiology resource announcements, 2019, 10.1128/mra.00013-19
  • Genomics of the 35-kb pvd locus and analysis of novel pvdIJK genes implicated in pyoverdine biosynthesis in Pseudomonas aeruginosa, Levesque, R.C., Sanschagrin, F., Lehoux, D.E., FEMS Microbiology Letters, 2000, 10.1016/S0378-1097(00)00314-1
  • Structure of CARB-4 and AER-1 carbenicillin hydrolyzing β-lactamases, Levesque, R.C., Bejaoui, N., Sanschagrin, F., Antimicrobial Agents and Chemotherapy, 1998, 10.1128/aac.42.8.1966
  • Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa., , ACS infectious diseases, 2021, 10.1021/acsinfecdis.1c00175
  • PDP-Miner: an AI/ML tool to detect prophage tail proteins with depolymerase domains across thousands of bacterial genomes, Roger C. Levesque, Irena Kukavica-Ibrulj, Jeff Gauthier, 2025, 10.1101/2025.01.20.633936
  • A colposcopical lesion of the uterine cervix frequently associated with papillomavirus type 16 as detected by in situ and southern blot hybridization: A cytohistological correlation study, Meisels, A., Levesque, R., Fortier, M., Bouchard, C., Morin, C., International Journal of Cancer, 1988, 10.1002/ijc.2910410410
  • Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF, Levesque, R.C., Bugg, T.D.H., Blewett, A., Clarke, T., Sanschagrin, F., Lloyd, A., Paradis-Bleau, C., BMC Biochemistry, 2008, 10.1186/1471-2091-9-33
  • Transcription of foreign DNA in Escherichia coli, Holt, R.A., Flibotte, S., Smailus, D.E., Levesque, R.C., Freeman, J.D., Warren, R.L., Genome Research, 2008, 10.1101/gr.080358.108
  • Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan, Dowson, C.G., Roper, D.I., Bugg, T.D.H., Tomasz, A., Catherwood, A.C., Levesque, R.C., El Zoeiby, A., De Pascale, G., Blewett, A.M., Gilbey, A.M., Lloyd, A.J., Journal of Biological Chemistry, 2008, 10.1074/jbc.M708105200
  • Structure-function studies of Ser-289 in the class C β-lactamase from Enterobacter cloacae P99, Huletsky, A., Levesque, R.C., Sanschagrin, F., Clairoux, N., Knox, J.R., Trépanier, S., Antimicrobial Agents and Chemotherapy, 1999, 10.1128/aac.43.3.543
  • Construction of a DNA probe and detection of Actinobacillus pleuropneumoniae by using polymerase chain reaction, Levesque, R.C., Lemire, E.G., Sirois, M., Journal of Clinical Microbiology, 1991, 10.1128/jcm.29.6.1183-1187.1991
  • The Pseudomonas aeruginosa Population among Cystic Fibrosis Patients in Quebec, Canada: a Disease Hot Spot without Known Epidemic Isolates., , Journal of clinical microbiology, 2019, 10.1128/jcm.02019-18
  • Identification of endomycorrhizal fungi colonizing roots by fluorescent single-strand conformation polymorphism-polymerase chain reaction, Lalonde, M., Levesque, R.C., Simon, L., Applied and Environmental Microbiology, 1993, 10.1128/aem.59.12.4211-4215.1993
  • Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the liverpool epidemic strain of pseudomonas aeruginosa, Levesque, R.C., Brinkman, F.S.L., Hancock, R.E.W., Parkhill, J., Harris, D., Saunders, D., Seeger, K., Clarke, L., Bignell, A., Lennard, N., Quail, M.A., Winsor, G.L., Thomson, N.R., Sanschagrin, F., Paradis-Bleau, C., Kukavica-Ibrulj, I., Fothergill, J.L., Langille, M.G.I., Winstanley, C., Genome Research, 2009, 10.1101/gr.086082.108
  • Comparative analysis of the 16S to 23S ribosomal intergenic spacer sequences of Bacillus thuringiensis strains and subspecies and of closely related species, Levesque, R.C., Lavoie, M.C., Valero, J.R., Bourque, S.N., Applied and Environmental Microbiology, 1995, 10.1128/aem.61.4.1623-1626.1995
  • Development of natural and synthetic DNA probes for OXA-2 and TEM-1 β-lactamases, Levesque, R.C., Mercier, J., Boissinot, M., Antimicrobial Agents and Chemotherapy, 1987, 10.1128/AAC.31.5.728
  • Sequencing of the Dutch elm disease fungus genome using the Roche/454 GS-FLX titanium system in a comparison of multiple genomics core facilities, Dewar, K., Levesque, R., Bernier, L., Jacobi, V., Hintz, W., Adams, S., Bintzler, D., Perera, A., Steen, R., Kieleczawa, J., Zianni, M., Peterson, N., Singh, S., Wright, C., Genik, S., Lyons Jr., R., Grove, D., Dias, J., Leveque, G., Forgetta, V., Journal of Biomolecular Techniques, 2013, 10.7171/jbt.12-2401-005
  • A standard numbering scheme for the class A β-lactamases [1], Waley, S.G., Tiraby, G., Levesque, R.C., Forsman, M., Joris, B., Ghuysen, J.-M., Frere, J.-M., Coulson, A.F.W., Ambler, R.P., Biochemical Journal, 1991, 10.1042/bj2760269
  • Convergent herbivory on conifers by Choristoneura moths after boreal forest formation., , Molecular phylogenetics and evolution, 2018, 10.1016/j.ympev.2018.01.013
  • Phenomic and genomic approaches to studying the inhibition of multiresistant Salmonella enterica by microcin J25., , Environmental microbiology, 2020, 10.1111/1462-2920.15045
  • A Syst-OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis., , Frontiers in microbiology, 2017, 10.3389/fmicb.2017.00996
  • Pseudomonas aeruginosa PA01 Bacterial Artificial Chromosomes: Strategies for Mapping, Screening, and Sequencing 100 kb Loci of the 5.9 Mb Genome, Levesque, R.C., Birren, B., Sanschagrin, F., Veilleux, F., Cardinal, G., Sabbagh, L., Dewar, K., Microbial and Comparative Genomics, 1998, 10.1089/omi.1.1998.3.105
  • Multiplex polymerase chain reaction for detection and differentiation of the microbial insecticide Bacillus thuringiensis, Levesque, R.C., Lavoie, M.C., Mercier, J., Valero, J.R., Bourque, S.N., Applied and Environmental Microbiology, 1993, 10.1128/aem.59.2.523-527.1993
  • Comparative genomic analysis of 142 bacteriophages infecting Salmonella enterica subsp. enterica, Ogunremi, D., Goodridge, L., Levesque, R., Moineau, S., Naushad, S., Gao, R., BMC Genomics, 2020, 10.1186/s12864-020-6765-z
  • The Pseudomonas aeruginosa Pan-Genome Provides New Insights on Its Population Structure, Horizontal Gene Transfer, and Pathogenicity., , Genome biology and evolution, 2019, 10.1093/gbe/evy259
  • Evaluation of inhibition of the carbenicillin-hydrolyzing β-lactamase PSE-4 by the clinically used mechanism-based inhibitors, Levesque, R.C., Mobashery, S., Sanschagrin, F., Kotra, L.P., Therrien, C., FEBS Letters, 2000, 10.1016/S0014-5793(00)01342-9
  • Genomics of antibiotic-resistance prediction in Pseudomonas aeruginosa., , Annals of the New York Academy of Sciences, 2017, 10.1111/nyas.13358
  • Physical and genetic mapping of cloned ribosomal DNA from Toxoplasma gondii: primary and secondary structure of the 5S gene, Levesque, R.C., Tremblay, A., Gagnon, S., Huot, A., Guay, J.-M., Gene, 1992, 10.1016/0378-1119(92)90570-F
  • Genomic characterisation of an international Pseudomonas aeruginosa reference panel indicates that the two major groups draw upon distinct mobile gene pools., , FEMS microbiology letters, 2018, 10.1093/femsle/fny120
  • The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa, Hancock, R.E.W., Levesque, R.C., Cosseau, C., Bains, M., McPhee, J.B., Sanschagrin, F., Gellatly, S.L., Gooderham, W.J., Microbiology, 2009, 10.1099/mic.0.024554-0
  • Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections., , Molecular pharmaceutics, 2020, 10.1021/acs.molpharmaceut.9b00968
  • Evolutionary perspectives on multiresistance β-lactamase transposons, Levesque, R.C., Vezina, G., Couture, F., Lafond, M., Journal of Bacteriology, 1989, 10.1128/jb.171.12.6423-6429.1989
  • Differential regulation of twitching motility and elastase production by Vfr in Pseudomonas aeruginosa, Mattick, J.S., Levesque, R.C., Sargent, J.L., Whitchurch, C.B., Beatson, S.A., Journal of Bacteriology, 2002, 10.1128/JB.184.13.3605-3613.2002
  • Requirement of the Pseudomonas aeruginosa CbrA sensor kinase for full virulence in a murine acute lung infection model, Hancock, R.E.W., Overhage, J., Levesque, R.C., Hilchie, A., Kukavica-Ibrulj, I., Neidig, A., Pena, O.M., Janot, L., Yeung, A.T.Y., Infection and Immunity, 2014, 10.1128/IAI.01527-13
  • A new approach to study attached biofilms and floating communities from Pseudomonas aeruginosa strains of various origins reveals diverse effects of divalent ions., , FEMS microbiology letters, 2018, 10.1093/femsle/fny155
  • Molecular distribution of ROB-1 β-lactamase in Actinobacillus pleuropneumoniae, Levesque, R.C., Medeiros, A.A., Sirois, M., Juteau, J.-M., Antimicrobial Agents and Chemotherapy, 1991, 10.1128/AAC.35.7.1397
  • Sigma factors in Pseudomonas aeruginosa, Levesque, R.C., Sanschagrin, F., Potvin, E., FEMS Microbiology Reviews, 2008, 10.1111/j.1574-6976.2007.00092.x
  • Origin and diversification of endomycorrhizal fungi and coincidence with vascular land plants, Lalonde, M., Lévesque, R.C., Bousquet, J., Simon, L., Nature, 1993, 10.1038/363067a0
  • Increase in the in vitro susceptibility of Staphylococcus aureus to antimicrobiol agents in the presence of Candida albicans, Mathieu, L.G., Levesque, R., DeRepentigny, J., Canadian Journal of Microbiology, 1979, 10.1139/m79-066
  • Rapid quantitation by PCR of endomycorrhizal fungi colonizing roots, Lalonde, M., Lévesque, R.C., Simon, L., Genome Research, 1992, 10.1101/gr.2.1.76
  • Strategy for genome sequencing analysis and assembly for comparative genomics of Pseudomonas genomes, Levesque, R.C., Tucker, N.P., Boyle, B., Jeukens, J., Methods in Molecular Biology, 2014, 10.1007/978-1-4939-0473-0_43
  • The Lon Protease Is Essential for Full Virulence in Pseudomonas aeruginosa, Hancock, R.E.W., Overhage, J., Levesque, R.C., Gellatly, S.L., Kukavica-Ibrulj, I., Taylor, P.K., Strehmel, J., Fernandez, L., Janot, L., Breidenstein, E.B.M., PLoS ONE, 2012, 10.1371/journal.pone.0049123
  • Sequence analysis and evolutionary perspectives of ROB-1 β-lactamase, Levesque, R.C., Juteau, J.-M., Antimicrobial Agents and Chemotherapy, 1990, 10.1128/AAC.34.7.1354
  • Bacteriophage-Induced Lipopolysaccharide Mutations in Escherichia coli Lead to Hypersensitivity to Food Grade Surfactant Sodium Dodecyl Sulfate, , Antibiotics, 2020, 10.3390/antibiotics9090552
  • Sequencing, assembly and annotation of the whole-insect genome of Lymantria dispar dispar, the European gypsy moth, Gundersen-Rindal, D.E., Levesque, R.C., Cusson, M., Hamelin, R.C., Johnston, J.S., Hebert, F.O., Sparks, M.E., G3: Genes, Genomes, Genetics, 2021, 10.1093/g3journal/jkab150
  • Polymerase chain reaction-based signature-tagged mutagenesis., Lehoux, D.E., Levesque, R.C., Methods in molecular biology (Clifton, N.J.), 2002, 10.1385/1-59259-194-9:127
  • Genome evolution drives transcriptomic and phenotypic adaptation in Pseudomonas aeruginosa during 20 years of infection, Iain L. Lamont, Roger C. Levesque, Ben Brockway, Marianne Potvin, Lois W. Martin, Jeff Gauthier, Samuel J.T. Wardell, Microbial Genomics, 2021, 10.1099/mgen.0.000681
  • Molecular characterization of the class II multiresistance transposable element Tn1403 from Pseudomonas aeruginosa, Levesque, R.C., Vezina, G., Antimicrobial Agents and Chemotherapy, 1991, 10.1128/AAC.35.2.313
  • Combinatorial biochemistry and shuffling of TEM, SHV and Streptomyces albus omega loops in PSE-4 class A β-lactamase, Levesque, R.C., Voyer, N., Sabbagh, Y., Thériault, E., Sanschagrin, F., Journal of Antimicrobial Chemotherapy, 2000, 10.1093/jac/45.4.517
  • Similar yet different: Phylogenomic analysis to delineate Salmonella and Citrobacter species boundaries, Tamber, S., Goodridge, L., Levesque, R.C., Bekal, S., Verster, A.J., Dussault, F.M., Petronella, N., Pilar, A.V.C., BMC Genomics, 2020, 10.1186/s12864-020-06780-y
  • Mutational spectra analysis reveals bacterial niche and transmission routes, Julian Parkhill, R. Andres Floto, Tom L. Blundell, Roger C. Lévesque, Gemma G. R. Murray, Marta Matuszewska, Arun Prasad Pandurangan, Gerry Tonkin-Hill, Aaron Weimann, Christopher Ruis, 2022, 10.1101/2022.07.13.499881
  • Genomic and Phenotypic Analysis of Salmonella enterica Bacteriophages Identifies Two Novel Phage Species, Lawrence Goodridge, Michelle Danyluk, Roger C. Levesque, Pascal Delaquis, Siyun Wang, Brian Boyle, Irena Kukavica-Ibrulj, Margot Amitrano, Elizabeth Tompkins, Zeyan Zhong, Yella Zahirovich-Jovich, Brigitte Cadieux, Anna Colavecchio, Opeyemi U Lawal, Dr. Sudhakar Bhandare, Microorganisms, 2024, 10.3390/microorganisms12040695
  • Characteristics and comparative study of five Rhizobium meliloti bacteriophages, Levesque, R.C., Ackermann, H.-W., Werquin, M., Current Microbiology, 1989, 10.1007/BF01575946
  • Composition of the spruce budworm (Choristoneura fumiferana) midgut microbiota as affected by rearing conditions, Levesque, R.C., Cusson, M., Derome, N., Comeau, A.M., Landry, M., PLoS ONE, 2015, 10.1371/journal.pone.0144077
  • Molecular basis of antibiotic resistance and β-lactamase inhibition by mechanism-based inactivators: Perspectives and future directions, Levesque, R.C., Therrien, C., FEMS Microbiology Reviews, 2000, 10.1016/S0168-6445(99)00039-X
  • Direct In Vivo Microbial Transcriptomics During Infection., , Trends in microbiology, 2018, 10.1016/j.tim.2018.07.002
  • β-lactamases: Clinical and genetic perspectives, Levesque, R., Pechère, J.-C., Journal of Antimicrobial Chemotherapy, 1983, 10.1093/jac/12.6.529
  • Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme, Levesque, R.C., Bugg, T.D.H., Sanschagrin, F., Lloyd, A., Boudreault, L., Beaumont, M., Paradis-Bleau, C., Peptides, 2006, 10.1016/j.peptides.2006.01.017
  • Liverpool Epidemic Strain Isolates of Pseudomonas aeruginosa Display High Levels of Antimicrobial Resistance during Both Planktonic and Biofilm Growth., , Microbiology spectrum, 2022, 10.1128/spectrum.01024-22
  • Characterization of Four Novel Bacteriophages Isolated from British Columbia for Control of Non-typhoidal Salmonella in Vitro and on Sprouting Alfalfa Seeds., , Frontiers in microbiology, 2017, 10.3389/fmicb.2017.02193
  • Animal models of chronic lung infection with Pseudomonas aeruginosa: Useful tools for cystic fibrosis studies, Levesque, R.C., Kukavica-Ibrulj, I., Laboratory Animals, 2008, 10.1258/la.2007.06014e
  • Insights into the molecular basis for the carbenicillinase activity of PSE-4 β-lactamase from crystallographic and kinetic studies, Strynadka, N.C.J., Levesque, R.C., De Castro, L., Passmore, L., Sanschagrin, F., Lim, D., Biochemistry, 2001, 10.1021/bi001653v
  • Reassessment of the status of Lymantria albescens and Lymantria postalba (Lepidoptera: Erebidae: Lymantriinae) as distinct ‘Asian gypsy moth’ species, using both mitochondrial and nuclear sequence data, Cusson, M., Hamelin, R.C., Levesque, R.C., Martemyanov, V.V., Inoue, M.N., Zahiri, R., Holden, D., Stewart, D., Nisole, A., Djoumad, A., Systematic Entomology, 2020, 10.1111/syen.12410
  • Comparative signature-tagged mutagenesis identifies Pseudomonas factors conferring resistance to the pulmonary collectin SP-A, Lau, G.W., McCormack, F.X., Levesque, R.C., Sanschagrin, F., Potvin, E., Chen, Y., Zhang, S., PLoS Pathogens, 2005, 10.1371/journal.ppat.0010031
  • Diversity and Host Specificity Revealed by Biological Characterization and Whole Genome Sequencing of Bacteriophages Infecting Salmonella enterica., , Viruses, 2019, 10.3390/v11090854
  • Temperate phages enhance pathogen fitness in chronic lung infection, Winstanley, C., Brockhurst, M.A., Levesque, R.C., Kukavica-Ibrulj, I., James, C.E., Davies, E.V., ISME Journal, 2016, 10.1038/ismej.2016.51
  • 1H, 13C, and 15N backbone resonance assignments for PSE-4, a 29.5 kDa class A beta-lactamase from Pseudomonas aeruginosa., Gagné, S.M., Levesque, R.C., Morin, S., Journal of biomolecular NMR, 2006, 10.1007/s10858-005-5343-7
  • Transmission, adaptation and geographical spread of the Pseudomonas aeruginosa Liverpool epidemic strain., , Microbial genomics, 2021, 10.1099/mgen.0.000511
  • Mutational spectra are associated with bacterial niche, Julian Parkhill, R. Andres Floto, Tom L. Blundell, Roger C. Lévesque, Gemma G. R. Murray, Marta Matuszewska, Arun Prasad Pandurangan, Gerry Tonkin-Hill, Aaron Weimann, Christopher Ruis, Nature Communications, 2023, 10.1038/s41467-023-42916-w
  • Peptidoglycan lytic activity of the Pseudomonas aeruginosa phage φKZ gp144 lytic transglycosylase, Levesque, R.C., Garnier, A., Auger, M., Laroche, J., Sanschagrin, F., Lemieux, L., Cloutier, I., Paradis-Bleau, C., FEMS Microbiology Letters, 2007, 10.1111/j.1574-6968.2006.00523.x
  • Glycoside hydrolase family 32 is present in Bacillus subtilis phages, Levesque, R.C., Maaroufi, H., Virology Journal, 2015, 10.1186/s12985-015-0373-6
  • Novel antimicrobial anionic cecropins from the spruce budworm feature a poly-L-aspartic acid C-terminus., , Proteins, 2021, 10.1002/prot.26142
  • Prophage Integrase Typing Is a Useful Indicator of Genomic Diversity in Salmonella enterica., , Frontiers in microbiology, 2017, 10.3389/fmicb.2017.01283
  • A multi-host approach to identify a transposon mutant of Pseudomonas aeruginosa LESB58 lacking full virulence., , BMC research notes, 2018, 10.1186/s13104-018-3308-7
  • Fate of 43 Salmonella Strains on Lettuce and Tomato Seedlings., , Journal of food protection, 2019, 10.4315/0362-028x.jfp-18-435
  • Assessing Pseudomonas aeruginosa virulence and the host response using Murine models of acute and chronic lung infection, Bragonzi, A., Levesque, R.C., Cigana, C., Facchini, M., Kukavica-Ibrulj, I., Methods in Molecular Biology, 2014, 10.1007/978-1-4939-0473-0_58
  • Single nucleotide variants in Pseudomonas aeruginosa populations from sputum correlate with baseline lung function and predict disease progression in individuals with cystic fibrosis, B. Jesse Shapiro, Dao Nguyen, Roger Levesque, Brian Boyle, Michael D. Parkins, Nicole Acosta, Inès Levade, Jannik Donner, Morteza M. Saber, 2021, 10.1101/2021.10.04.21264421
  • Discovery of new MurF inhibitors via pharmacophore modeling and QSAR analysis followed by in-silico screening, Levesque, R.C., Younis, K.S., Zalloum, H., Paradis-Bleau, C., Al-Bakri, A.G., Atallah, N., Taha, M.O., Bioorganic and Medicinal Chemistry, 2008, 10.1016/j.bmc.2007.10.076
  • Culture-Dependent Bioprospecting of Bacterial Isolates From the Canadian High Arctic Displaying Antibacterial Activity., , Frontiers in microbiology, 2019, 10.3389/fmicb.2019.01836
  • Draft genome sequences of two lipopeptide-producing strains of Bacillus methylotrophicus, Levesque, R.C., Jabaji, S., Freschi, L., Kukavica-Ibrulj, I., Jeukens, J., Genome Announcements, 2015, 10.1128/genomeA.01176-15
  • A megaplasmid family responsible for dissemination of multidrug resistance in Pseudomonas, Winstanley, C., Fothergill, J.L., Levesque, R.C., Santanirand, P., Pongchaikul, P., Wright, L.L., Emond-Rhéault, J.-G., Grimes, M., Moore, M.P., Cazares, A., bioRxiv, 2019, 10.1101/630780
  • Complete Genome Sequences of Two Phage-Like Plasmids Carrying the CTX-M-15 Extended-Spectrum β-Lactamase Gene., , Genome announcements, 2017, 10.1128/genomea.00102-17
  • Expansion of LINEs and species-specific DNA repeats drives genome expansion in Asian Gypsy Moths., , Scientific reports, 2019, 10.1038/s41598-019-52840-z
  • Genome-wide SNPs resolve phylogenetic relationships in the North American spruce budworm (Choristoneura fumiferana) species complex, Sperling, F.A.H., Powell, J.A., Cusson, M., Levesque, R., Boyle, B., Fagua, G., Lumley, L.M., Bird, H.M., Brunet, B.M.T., Dupuis, J.R., Molecular Phylogenetics and Evolution, 2017, 10.1016/j.ympev.2017.04.001
  • Functional genomics PycR, a LysR family transcriptional regulator essential for maintenance of Pseudomonas aeruginosa in the rat lung, Levesque, R.C., MacKay, J., Boyle, B., Whiteley, M., Peterson, A., Sanschagrin, F., Kukavica-Ibrulj, I., Microbiology, 2008, 10.1099/mic.0.2007/011239-0
  • Species interactions and distinct microbial communities in high Arctic permafrost affected cryosols are associated with the CH4 and CO2 gas fluxes, Whyte, L.G., Greer, C.W., Lévesque, R., Magnuson, E., Turney, S., Hamel, J., Altshuler, I., Environmental Microbiology, 2019, 10.1111/1462-2920.14715
  • Comparative genomics and biological characterization of sequential Pseudomonas aeruginosa isolates from persistent airways infection, Bragonzi, A., Levesque, R.C., Tümmler, B., Kukavica-Ibrulj, I., Molinaro, A., Boyle, B., Facchini, M., Alcalá-Franco, B., Freschi, L., Jeukens, J., Bianconi, I., BMC Genomics, 2015, 10.1186/s12864-015-2276-8
  • Identification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide libraries, Levesque, R.C., Brisson, J.-R., Darveau, A., Sanschagrin, F., El Zoeiby, A., Journal of Antimicrobial Chemotherapy, 2003, 10.1093/jac/dkg010
  • Genes required for free phage production are essential for pseudomonas aeruginosa chronic lung infections, Levesque, R.C., Winstanley, C., Tucker, N.P., Laroche, J., Boyle, B., Fothergill, J.L., Kukavica-Ibrulj, I., Jeukens, J., Lemieux, A.-A., Journal of Infectious Diseases, 2016, 10.1093/infdis/jiv415
  • Heterogeneity among virulence and antimicrobial resistance gene profiles of extraintestinal Escherichia coli isolates of animal and human origin, Harel, J., Larivière, S., Masson, L., Brousseau, R., Levesque, R.C., Sanschagrin, F., Bekal, S., Maynard, C., Journal of Clinical Microbiology, 2004, 10.1128/JCM.42.12.5444-5452.2004
  • Nucleotide sequence and phylogeny of SHV-2 β-lactamase, Levesque, R.C., Couture, F., Huletsky, A., Antimicrobial Agents and Chemotherapy, 1990, 10.1128/AAC.34.9.1725
  • Distinct sources of gene flow produce contrasting population genetic dynamics at different range boundaries of a Choristoneura budworm., , Molecular ecology, 2017, 10.1111/mec.14386
  • Mapping of a plasmid (pLQ3) from Achromobacter and cloning of its cephalosporinase gene in Escherichia coli, Roy, P.H., Levesque, R., Gene, 1982, 10.1016/0378-1119(82)90057-9
  • Cloning and expression of the imipenem-hydrolyzing β-lactamase operon from Pseudomonas maltophilia in Escherichia coli, Levesque, R.C., Vezina, G., Dufresne, J., Antimicrobial Agents and Chemotherapy, 1988, 10.1128/AAC.32.6.819
  • Structure-function analysis of α-helix H4 using PSE-4 as a model enzyme representative of class A β-lactamases, Levesque, R.C., Voyer, N., Palzkill, T., Sanschagrin, F., Savoie, A., Protein Engineering, 2000, 10.1093/protein/13.4.267
  • Genomic and Phenotypic Analysis of Salmonella enterica Bacteriophages Identifies Two Novel Phage Species, , 1911, 10.20944/preprints202403.0561.v2
  • Continent-wide population genomic structure and phylogeography of North America's most destructive conifer defoliator, the spruce budworm (Choristoneura fumiferana)., , Ecology and evolution, 2020, 10.1002/ece3.5950
  • Combined use of Oxford Nanopore and Illumina sequencing yields insights into soybean structural variation biology, François Belzile, Roger C. Levesque, Jérémie Hamel, Davoud Torkamaneh, Jonas A. Sibbesen, Marc-André Lemay, 2021, 10.1101/2021.08.26.457816
  • An animal source for the ROB-1 β-lactamase of Haemophilus influenzae type b, Jacoby, G.A., Levesque, R., Medeiros, A.A., Antimicrobial Agents and Chemotherapy, 1986, 10.1128/AAC.29.2.212
  • Molybdate transporter ModABC is important for Pseudomonas aeruginosa chronic lung infection., , BMC research notes, 2016, 10.1186/s13104-016-1840-x
  • A megaplasmid family driving dissemination of multidrug resistance in Pseudomonas., , Nature communications, 2020, 10.1038/s41467-020-15081-7
  • Structural insights into the putative bacterial acetylcholinesterase ChoE and its substrate inhibition mechanism., , The Journal of biological chemistry, 2020, 10.1074/jbc.ra119.011809
  • Genomic and Phenotypic Analysis of Salmonella enterica Bac-Teriophages Identifies Two Novel Phage Species, , 1911, 10.20944/preprints202403.0561.v1
  • A Multi-Species TaqMan PCR Assay for the Identification of Asian Gypsy Moths (Lymantria spp.) and Other Invasive Lymantriines of Biosecurity Concern to North America., , PloS one, 2016, 10.1371/journal.pone.0160878
  • The widespread multidrug-resistant serotype O12 pseudomonas aeruginosa clone emerged through concomitant horizontal transfer of serotype antigen and antibiotic resistance gene clusters, Jelsbaka, L., Lam, J.S., Lévesque, R.C., Pirnay, J.-P., Laroche, J., Boyle, B., Kukavica-Ibrulj, I., Freschi, L., Taylor, V.L., Thrane, S.W., mBio, 2015, 10.1128/mBio.01396-15
  • Erratum: Comparative analysis of the 16S to 23S ribosomal intergenic spacer sequences of Bacillus thuringiensis strains and subspecies and of closely related species (Applied and Environmental Microbiology 61:4 (1624- 1626)), Levesque, R.C., Lavoie, M.C., Valero, J.R., Bourque, S.N., Applied and Environmental Microbiology, 1995
  • Bacteriophage-Insensitive Mutants of Antimicrobial-Resistant Salmonella Enterica are Altered in their Tetracycline Resistance and Virulence in Caco-2 Intestinal Cells., , International journal of molecular sciences, 2020, 10.3390/ijms21051883
  • Complete genome sequence of persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73, Levesque, R.C., Bragonzi, A., Tümmler, B., Kukavica-Ibrulj, I., Bianconi, I., Boyle, B., Jeukens, J., Genome Announcements, 2013, 10.1128/genomeA.00568-13
  • Salmonella enterica subsp. enterica virulence potential can be linked to higher survival within a dynamic in vitro human gastrointestinal model., , Food microbiology, 2021, 10.1016/j.fm.2021.103877
  • Salmonella enterica Prophage Sequence Profiles Reflect Genome Diversity and Can Be Used for High Discrimination Subtyping., , Frontiers in microbiology, 2018, 10.3389/fmicb.2018.00836
  • Essential genes in the infection model of pseudomonas aeruginosa -PCR-based signature-tagged mutagenesis, Levesque, R.C., Kukavica-Ibrulj, I., Methods in Molecular Biology, 2015, 10.1007/978-1-4939-2398-4_7
  • Cloning, sequencing and expression in Escherichia coli of the ptsI gene encoding enzyme I of the phosphoenolpyruvate:sugar phosphotransferase transport system from Streptococcus salivarius, Frenette, M., Levesque, R.C., Vadeboncoeur, C., Gagnon, G., Gene, 1992, 10.1016/0378-1119(92)90163-J
  • Temporal variation in spatial genetic structure during population outbreaks: Distinguishing among different potential drivers of spatial synchrony., , Evolutionary applications, 2019, 10.1111/eva.12852
  • Phylogeny of LCR‐1 and OXA‐5 with class A and class D β‐lactamases, Levesque, R.C., Lachapelle, J., Couture, F., Molecular Microbiology, 1992, 10.1111/j.1365-2958.1992.tb00894.x
  • Molecular heterogeneity of the L-1 metallo-β-lactamase family from Stenotrophomonas maltophilia, Levesque, R.C., Dufresne, J., Sanschagrin, F., Antimicrobial Agents and Chemotherapy, 1998, 10.1128/aac.42.5.1245
  • Positive signature-tagged mutagenesis in Pseudomonas aeruginosa: Tracking patho-adaptive mutations promoting airways chronic infection, Bragonzi, A., Bertoni, G., Levesque, R.C., Paroni, M., Cigana, C., Milani, A., Bianconi, I., PLoS Pathogens, 2011, 10.1371/journal.ppat.1001270
  • Systematic site-saturation mutagenesis of ROB-1 β-lactamase: Efficiency of T4 polymerase and oligonucleotide synthesis, Levesque, R.C., Cote, S., Juteau, J.-M., BioTechniques, 1991
  • Monoclonal antibodies to TEM-1 plasmid-mediated β-lactamase, Letarte, R., Levesque, R.C., Patel, P.C., Morin, C.J., Antimicrobial Agents and Chemotherapy, 1987, 10.1128/AAC.31.11.1761
  • Identification of a ROB-1 β-lactamase in Haemophilus ducreyi, Ronald, A.R., Albritton, W.L., Levesque, R.C., Juteau, J.-M., Slaney, L., Maclean, I.W., Antimicrobial Agents and Chemotherapy, 1992, 10.1128/AAC.36.2.467
  • Toxoplasma gondii: Structure and characterization of the 26S ribosomal RNA and peptidyl transferase domain, Levesque, R.C., Bourbeau, D., Morency, M.-J., Gagnon, S., Experimental Parasitology, 1996, 10.1006/expr.1996.0082
  • Exacerbation induces a microbiota shift in sputa of COPD patients., , PloS one, 2018, 10.1371/journal.pone.0194355
  • BAC library construction, screening and clone sequencing of lake whitefish (Coregonus clupeaformis, Salmonidae) towards the elucidation of adaptive species divergence, Bernatchez, L., Lévesque, R.C., St-Cyr, J., Kukavica-Ibrulj, I., Boyle, B., Jeukens, J., Molecular Ecology Resources, 2011, 10.1111/j.1755-0998.2011.02982.x
  • The Pseudomonas aeruginosa whole genome sequence: A 20th anniversary celebration, Welch, M., Wang, M., Tümmler, B., Schweizer, H.P., Scurlock, M.W., Porter, S.L., Nikel, P.I., Lory, S., Levesque, R.C., Lamont, I.L., Klockgether, J., Häußler, S., Haney, C.H., Hancock, R.E.W., Han, K., Greenberg, E.P., Goldberg, J.B., Francis, V.I., Filloux, A., Done, R.E., Winsor, G.L., Brinkman, F.S.L., Advances in Microbial Physiology, 2021, 10.1016/bs.ampbs.2021.07.001
  • A specific peptide inhibitor of the class B metallo-β-lactamase L-1 from Stenotrophomonas maltophilia identified using phage display, Levesque, R.C., Sanschagrin, F., Journal of Antimicrobial Chemotherapy, 2005, 10.1093/jac/dkh550
  • Molecular cloning and expression of the imipenem-hydrolyzing β-lactamase gene from pseudomonas maltophilia in escherichia coli, Levesque, R.C., Vezina, G., Dufresne, J., Clinical Infectious Diseases, 1988, 10.1093/clinids/10.4.806
  • Role of Ser-238 and Lys-240 in the hydrolysis of third-generation cephalosporins by SHV-type β-lactamases probed by site-directed mutagenesis and three-dimensional modeling, Levesque, R.C., Knox, J.R., Huletsky, A., Journal of Biological Chemistry, 1993
  • Characterization of alanine catabolism in Pseudomonas aeruginosa and its importance for proliferation in vivo, Whiteley, M., Levesque, R.C., Barrera, K., Longoria, A., Kukavica-Ibrulj, I., Jorth, P.A., Baynham, P.J., Boulette, M.L., Journal of Bacteriology, 2009, 10.1128/JB.00817-09
  • Detection of genes essential in specific niches by signature-tagged mutagenesis, Levesque, R.C., Lehoux, D.E., Current Opinion in Biotechnology, 2000, 10.1016/S0958-1669(00)00124-5
  • Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium, Levesque, R.C., Winstanley, C., Tümmler, B., Tucker, N.P., Brinkman, F.S.L., Wright, G.D., Thrane, S.W., Williams, P., Waglechner, N., Turton, J.F., Taylor, V., Stephenson, A., Santos, P.M., Rousseau, S., Rainey, P.B., Pirnay, J.-P., Perron, G.G., Pereira, S.K., Nguyen, D., Naghra, H., Milot, J., McKeown, J., McArthur, A.G., Manos, J., Malouin, F., Loman, N., Lewenza, S., Lamont, I.L., Lam, J.S., Klockgether, J., Kidd, T.J., Kenna, D.T., Jia, B., Jelsbak, L., Heeb, S., Harrison, J.J., Hancock, R.E.W., Déziel, É., Grimwood, K., Dewar, K., Charette, S.J., Cantin, A., Camara, M., Burns, J.L., Bell, S.C., Barbeau, J., Aaron, S.D., Winsor, G.L., Moore, M., Fothergill, J.L., Maaroufi, H., Larose, S., Laroche, J., Dupont, M.-J., Boyle, B., Kukavica-Ibrulj, I., Jeukens, J., Freschi, L., Frontiers in Microbiology, 2015, 10.3389/fmicb.2015.01036
  • Draft Genome Sequences of Two Clostridium botulinum Group II Strains Carrying Phage-Like Plasmids., , Microbiology resource announcements, 2022, 10.1128/mra.00091-22
  • The Spruce Budworm Genome: Reconstructing the Evolutionary History of Antifreeze Proteins., , Genome biology and evolution, 2022, 10.1093/gbe/evac087
  • Essential genes in the infection model of Pseudomonas aeruginosa PCR-based signature-tagged mutagenesis, Levesque, R.C., Kukavica-Ibrulj, I., Sanschagrin, F., Methods in Molecular Biology, 2007
  • Complete Genome Sequence of a Pseudomonas Species Isolated from Tailings Pond Water in Alberta, Canada., , Microbiology resource announcements, 2021, 10.1128/mra.01174-20
  • In vivo functional genomics of pseudomonas: PCR-based signature-tagged mutagenesis, Levesque, R.C., Pseudomonas, 2006, 10.1007/0-387-28881-3_4
  • Inactivation of Salmonella enterica on post-harvest cantaloupe and lettuce by a lytic bacteriophage cocktail., , Current research in food science, 2019, 10.1016/j.crfs.2019.11.004
  • Assessing the potential of genotyping-by-sequencing-derived single nucleotide polymorphisms to identify the geographic origins of intercepted gypsy moth (Lymantria dispar) specimens: A proof-of-concept study, Cusson, M., Hamelin, R.C., Levesque, R.C., Boyle, B., Pouliot, E., Stewart, D., Havill, N., Keena, M., Picq, S., Evolutionary Applications, 2018, 10.1111/eva.12559
  • Reuse of voucher specimens provides insights into the genomic associations and taxonomic value of wing colour and genitalic differences in a pest group (Lepidoptera: Tortricidae: Choristoneura), Sperling, F.A.H., Levesque, R.C., Cusson, M., Lumley, L.M., Brunet, B.M.T., Lebunasin, P.N.A., French, R.L.K., Systematic Entomology, 2020, 10.1111/syen.12416
  • Combining Whole-Genome Sequencing and Multimodel Phenotyping To Identify Genetic Predictors of Salmonella Virulence., , mSphere, 2020, 10.1128/msphere.00293-20
  • Cyclic peptides identified by phage display are competitive inhibitors of the tRNA-dependent amidotransferase of Helicobacter pylori., , Peptides, 2016, 10.1016/j.peptides.2016.03.001
  • Strategies for isolation of in vivo expressed genes from bacteria, Levesque, R.C., Handfield, M., FEMS Microbiology Reviews, 1999, 10.1016/S0168-6445(98)00033-3
  • Nucleotide sequence of the PSE-4 carbenicillinase gene and correlations with Staphylococcus aureus PC1 β-lactamase crystal structure, Levesque, R.C., Boissinot, M., Journal of Biological Chemistry, 1990
  • The Salmonella enterica Plasmidome as a Reservoir of Antibiotic Resistance., , Microorganisms, 2020, 10.3390/microorganisms8071016
  • Whole-Genome Sequencing of Lactobacillus Species from Two Commercial Probiotic Products., , Genome announcements, 2017, 10.1128/genomea.01279-17
  • Biophysical studies of the interactions between the phage φ KZ gp144 lytic transglycosylase and model membranes, Auger, M., Levesque, R.C., Arseneault, M., Pigeon, X., Giroux, A.-M., Paradis-Bleau, C., Cloutier, I., European Biophysics Journal, 2010, 10.1007/s00249-009-0530-1
  • Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection., , Journal of pharmaceutical sciences, 2018, 10.1016/j.xphs.2018.09.017

Contribution à l'enseignement aux cycles supérieurs

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Depuis 2020/04
  • Anthony Piot - Post-doctorat - En cours

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  • Biologie cellulaire et moléculaire
  • Microbiologie-immunologie

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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