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Sébastien Hébert

Professeur titulaire

sebastien.hebert@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine :

Neurosciences et santé mentale

Projets de recherche en cours

  • Consortium pour l’identification précoce de la maladie d’Alzheimer (CIMA-Q) : renforcer l’intersectorialité, le rayonnement et le potentiel de découverte. - Fonds de recherche du Québec - Santé - Plateforme de financements de la recherche intersectorielle sur le vieillissement, co-chercheur - 2024-04-01 au 2028-03-31
  • Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-04-01 au 2027-03-31
  • Vascular MicroRNA-212 in CAA and Alzheimer's disease - National Institute of Health (USA), Temple University, co-chercheur - 2023-09-22 au 2025-08-31

Financements des 2 dernières années

  • Importance of non-canonical microRNAs in the mammalian brain - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2020-04-01 au 2025-03-31
  • Preclinical safety, pharmacokinetics, pharmacodynamics, and efficiency of microRNA oligonucleotides for Alzheimer's disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-03-01 au 2025-03-31

Publications

  • Memory formation and retention are affected in adult miR-132/212 knockout mice, Hébert, S.S., Goodman, R.H., Magill, S.T., Goupil, C., Planel, E., Filali, M., Smith, P.Y., Hernandez-Rapp, J., Behavioural Brain Research, 2015, 10.1016/j.bbr.2015.03.032
  • Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice, Planel, E., Marette, A., Hébert, S.S., Calon, F., Nicholls, S.B., Morin, F., Marcouiller, F., Julien, C., Papon, M.-A., Petry, F., Gratuze, M., El Khoury, N.B., Neurobiology of Disease, 2016, 10.1016/j.nbd.2016.01.005
  • Studying microRNAs in the brain: Technical lessons learned from the first ten years, Nelson, P.T., Hébert, S.S., Experimental Neurology, 2012, 10.1016/j.expneurol.2011.12.004
  • MicroRNAs underlying memory deficits in neurodegenerative disorders, Hébert, S.S., Rainone, S., Hernandez-Rapp, J., Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2017, 10.1016/j.pnpbp.2016.04.011
  • MicroRNAs and Alzheimer's disease mouse models: Current insights and future research avenues, Delay, C., Hébert, S.S., International Journal of Alzheimer's Disease, 2011, 10.4061/2011/894938
  • In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs, Hébert, S.S., Delay, C., Girard, J., Al Hashimi, A., Smith, P., Journal of Neurochemistry, 2011, 10.1111/j.1471-4159.2010.07097.x
  • Oligomerization of human presenilin-1 fragments, Lévesque, G., Godin, C., Hébert, S.S., FEBS Letters, 2003, 10.1016/S0014-5793(03)00813-5
  • MicroRNAs in Alzheimer's disease, Hébert, S.S., Mandemakers, W., Delay, C., Neurobiology of Disease, 2012, 10.1016/j.nbd.2012.01.003
  • Genetic ablation of dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration, de Strooper, B., Buée, L., Sergeant, N., Silahtaroglu, A.N., Planel, E., Galas, M.-C., Smith, P., Papadopoulou, A.S., Hébert, S.S., Human Molecular Genetics, 2010, 10.1093/hmg/ddq311
  • Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain, De Strooper, B., Notkins, A.L., Cai, T., Matta, S., Morais, V.A., Snellinx, A., Hébert, S.S., Caromile, L.A., Xu, H., Abuhatzira, L., Mandemakers, W., Diabetologia, 2013, 10.1007/s00125-013-2901-5
  • Striatal pre-enkephalin overexpression improves Huntington's disease symptoms in the R6/2 mouse model of Huntington's disease., Samadi, P., Drolet, G., Hébert, S.S., Vaillancourt, M., Bissonnette, S., PloS one, 2013
  • Hypothermia-induced hyperphosphorylation: A new model to study tau kinase inhibitors, Planel, E., Hébert, S.S., Lévesque, G., Mouginot, D., Poitras, I., Petry, F.R., El Khoury, N.B., Julien, C., Marcouiller, F., Bretteville, A., Scientific Reports, 2012, 10.1038/srep00480
  • Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription, Pietrzik, C.U., De Strooper, B., Weggen, S., Behl, C., Hébert, S.S., Martin, A.M., Jaeger, S., Kern, A., Isbert, S., Waldron, E., Experimental Cell Research, 2008, 10.1016/j.yexcr.2008.05.003
  • Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells, De Smedt, H., Missiaen, L., Parys, J.B., Callewaert, G., Hébert, S.S., Verbert, L., Kocks, S.L., Kasri, N.N., Cell Calcium, 2006, 10.1016/j.ceca.2006.03.005
  • A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls, Nelson, P.T., Zhu, Q., Wang, W.-X., Hébert, S.S., Journal of Alzheimer's Disease, 2013, 10.3233/JAD-122350
  • Alzheimer research forum live discussion: Non-coding RNAs in neurodegeneration, Xu, G., Wang, W.-X., Umansky, S., Turner, L., Townsend, M., Stanek, L., Smalheiser, N., Perry, R., Nelson, P., Neilson, J., Muresan, V., Mizumoto, L., Maloney, B., Long, J., Kosik, K., Kinoshita, J., Hebert, S., Hayashi, M., Frederikse, P., Cuellar, T., Chang, R., Chai, X., Cashikar, A., Breen, G., Albensi, B., Journal of Alzheimer's Disease, 2009, 10.3233/JAD-2009-1007
  • Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function, Hébert, S.S., Mathews, P., Calon, F., Delay, C., Molecular Neurodegeneration, 2011, 10.1186/1750-1326-6-70
  • The amyloid-β precursor protein: Integrating structure with biological function, De Strooper, B., Hébert, S.S., Reinhard, C., EMBO Journal, 2005, 10.1038/sj.emboj.7600860
  • Gene network and pathway analysis of mice with conditional ablation of dicer in post-mitotic neurons, Hébert, S.S., Buée, L., Zommer, N., Planel, E., Calvo, E., Delay, C., Smith, P.Y., Dorval, V., PLoS ONE, 2012, 10.1371/journal.pone.0044060
  • A simple method to avoid nonspecific signal when using monoclonal anti-tau antibodies in western blotting of mouse brain proteins, Planel, E., Hébert, S.S., Nicholls, S.B., Petry, F.R., Methods in Molecular Biology, 2017, 10.1007/978-1-4939-6598-4_15
  • MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy, Hébert, S.S., Buée, L., Sergeant, N., Planel, E., Papon, M.l., Girard, J., Delay, C., Smith, P.Y., Human Molecular Genetics, 2011, 10.1093/hmg/ddr330
  • Extracellular Na+ levels regulate formation and activity of the Nax/alpha1-Na+/K+ -ATPase complex in neuronal cells, Drolet, G., Mouginot, D., Toth, K., Hebert, S.S., Soulet, D., Henry, M., Smith, P.Y., Berret, E., Frontiers in Cellular Neuroscience, 2014, 10.3389/fncel.2014.00413
  • MicroRNA regulation of Alzheimer's Amyloid precursor protein expression, De Strooper, B., Delacourte, A., Papadopoulou, A.S., Bergmans, B., Nicolaï, L., Horré, K., Hébert, S.S., Neurobiology of Disease, 2009, 10.1016/j.nbd.2008.11.009
  • Specificity of anti-Tau antibodies when analyzing mice models of Alzheimer's disease: Problems and solutions, Planel, E., Whittington, R.A., H́ebert, S.S., Calon, F., Morin, F., Bretteville, A., Petry, F.R., Pelletier, J., PLoS ONE, 2014, 10.1371/journal.pone.0094251
  • Differential contribution of the three Aph1 genes to γ-secretase activity in vivo, De Strooper, B., Hartmann, D., Annaert, W., Zwijsen, A., Martens, G., Coolen, M., Hébert, S., Tousseyn, T., Jorissen, E., Horré, K., Craessaerts, K., Dejaegere, T., Serneels, L., Proceedings of the National Academy of Sciences of the United States of America, 2005, 10.1073/pnas.0408901102
  • MicroRNAs and the regulation of Tau metabolism, Buée, L., Sergeant, N., Hébert, S.S., International Journal of Alzheimer's Disease, 2012, 10.1155/2012/406561
  • The miR-15/107 group of MicroRNA genes: Evolutionary biology, cellular functions, and roles in human diseases, Nelson, P.T., Mao, G., Wilfred, B.R., Hébert, S.S., Wang, W.-X., Finnerty, J.R., Journal of Molecular Biology, 2010, 10.1016/j.jmb.2010.07.051
  • MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms, Hébert, S.S., Hsiung, G.-Y., Lambert, J.-C., Grenier-Boley, B., Fok, A., Dorval, V., Delay, C., Frontiers in Molecular Neuroscience, 2014, 10.3389/fnmol.2014.00067
  • LRRK2 in transcription and translation regulation: Relevance for Parkinson's disease, Hébert, S.S., Dorval, V., Frontiers in Neurology, 2012, 10.3389/fneur.2012.00012
  • MicroRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice, Hébert, S.S., Cicchetti, F., Calon, F., Droit, A., Planel, E., Vallée, M., Saint-Pierre, M., Smith, P.Y., Dorval, V., Goupil, C., Rainone, S., Hernandez-Rapp, J., Scientific Reports, 2016, 10.1038/srep30953
  • Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain, Hassan, B.A., De Strooper, B., Reeve, S., Hébert, S.S., Ayaz, D., Leyssen, M., EMBO Journal, 2005, 10.1038/sj.emboj.7600757
  • Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease, Zhu, L.-Q., Lu, Y., Chen, J.-G., Hébert, S.S., Wang, J.-Z., Fu, P., Wang, D.-Q., Wang, X., Zhou, Y.-F., Wei, N., Deng, M.-F., Li, X.-Y., Tang, H., Liu, D., Molecular Therapy, 2017, 10.1016/j.ymthe.2017.01.018
  • Dimethyl sulfoxide induces both direct and indirect Tau hyperphosphorylation, Planel, E., Hébert, S.S., Baillargeon, J., El Khoury, N.B., Bretteville, A., Marcouiller, F., Julien, C., PLoS ONE, 2012, 10.1371/journal.pone.0040020
  • Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice, Glatzel, M., De Strooper, B., D'Hooge, R., Liston, A., Silahtaroglu, A., Neumann, M., Hébert, S.S., Spinazzi, M., Radaelli, E., Ayoubi, T., Lau, P., Dooley, J., Callaerts-Vegh, Z., Mandemakers, W., Achsel, T., Serneels, L., Papadopoulou, A.S., Neurobiology of Disease, 2015, 10.1016/j.nbd.2014.10.006
  • Alterations of the microRNA network cause neurodegenerative disease, De Strooper, B., Hébert, S.S., Trends in Neurosciences, 2009, 10.1016/j.tins.2008.12.003
  • Gene and microRNA transcriptome analysis of Parkinson's related LRRK2 mouse models, Hébert, S.S., De Strooper, B., Mazroui, R., Coudert, L., Jolivette, F., Mandemakers, W., Dorval, V., PLoS ONE, 2014, 10.1371/journal.pone.0085510
  • The mixed lineage kinase DLK is oligomerized by tissue transglutaminase during apoptosis, Blouin, R., Aubin, R.A., Latreille, M., Grondin, G., Daviau, A., Hebert, S.S., Journal of Biological Chemistry, 2000
  • Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1), Lévesque, G., Carreau, M., Ferland, M., Godin, C., Bourdages, V., Hébert, S.S., Neurobiology of Disease, 2003, 10.1016/S0969-9961(03)00035-4
  • Dimerization of presenilin-1 in vivo: Suggestion of novel regulatory mechanisms leading to higher order complexes, Lévesque, G., Mori, H., Tomiyama, T., Godin, C., Hébert, S.S., Biochemical and Biophysical Research Communications, 2003, 10.1016/S0006-291X(02)02984-4
  • Coordinated and widespread expression of γ-secretase in vivo: Evidence for size and molecular heterogeneity, De Strooper, B., Hartmann, D., Annaert, W., Baert, V., Dabrowski, M., Horré, K., Dejaegere, T., Serneels, L., Hébert, S.S., Neurobiology of Disease, 2004, 10.1016/j.nbd.2004.08.002
  • Preclinical evaluation of miR-15/107 family members as multifactorial drug targets for Alzheimer's disease, Hébert, S.S., Dorval, V., Goupil, C., Smith, P.Y., Parsi, S., Molecular Therapy - Nucleic Acids, 2015, 10.1038/mtna.2015.33
  • Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy, Rovelet-Lecrux, A., Hébert, S.S., Tournier-Lasserve, E., Hannequin, D., Campion, D., Frebourg, T., Preux, P.-M., Lambert, J.-C., Dartigues, J.-F., Mbelesso, P., Ndamba-Bandzouzi, B., Guerchet, M., Amouyel, P., Hervé, D., Riant, F., Sarov-Rivière, M., Dorval, V., Pottier, C., Richard, A.-C., Goupil, C., Wallon, D., Nicolas, G., European Journal of Human Genetics, 2016, 10.1038/ejhg.2015.61
  • The schizophrenia risk gene MIR137 acts as a hippocampal gene network node orchestrating the expression of genes relevant to nervous system development and function, Aschrafi, A., Martens, G.J.M., Kaplan, B.B., Hébert, S.S., van Bokhoven, H., Glennon, J.C., Nadif Kasri, N., Olde Loohuis, N.F.M., Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2017, 10.1016/j.pnpbp.2016.02.009
  • MiR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo, Hébert, S.S., Calon, F., Tremblay, M.È., Buée, L., Sergeant, N., Fernandez-Gomez, F.-J., Bennett, D.A., Planel, E., Morin, F., Parsi, S., Dorval, V., Goupil, C., Bisht, K., Lecours, C., Jolivette, F., Hernandez-Rapp, J., Smith, P.Y., Human Molecular Genetics, 2015, 10.1093/hmg/ddv377
  • Circulating microRNAs in Alzheimer's disease: The search for novel biomarkers, Hébert, S.S., Nelson, P.T., Dorval, V., Frontiers in Molecular Neuroscience, 2013, 10.3389/fnmol.2013.00024
  • Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression, De Strooper, B., Delacourte, A., Kauppinen, S., Silahtaroglu, A.N., Mandemakers, W., Papadopoulou, A.S., Nicolaï, L., Horré, K., Hébert, S.S., Proceedings of the National Academy of Sciences of the United States of America, 2008, 10.1073/pnas.0710263105
  • Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis, Vassar, R., Bennett, D.A., Haass, C., De Strooper, B., Hébert, S.S., Lichtenthaler, S.F., Lammich, S., Bembinster, L.A., Hitt, B., Eimer, W.A., Cole, S.L., Zhao, J., Velliquette, R.A., Maus, E., Sadleir, K.R., O'Connor, T., Neuron, 2008, 10.1016/j.neuron.2008.10.047
  • Epigenetic control of aquaporin 1 expression by the amyloid precursor protein, Octave, J.-N., De Strooper, B., Brion, J.-P., Devuyst, O., Leroy, K., Tasiaux, B., Hébert, S., Kienlen-Campard, P., Huysseune, S., FASEB Journal, 2009, 10.1096/fj.09-140012
  • Presenilin-I is indirectly implicated in Notchl cleavage, Lévesque, G., Carreau, M., Hébert, S.S., Ferland, M., Auclair, A., Godin, C., NeuroReport, 2003, 10.1097/00001756-200308260-00014
  • The effect of striatal pre-enkephalin overexpression in the basal ganglia of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease, Samadi, P., Hébert, S.S., Calon, F., Bezeau, F., Vernoux, N., Muratot, S., Bissonnette, S., European Journal of Neuroscience, 2014, 10.1111/ejn.12596
  • High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology, Planel, E., Marette, A., Hébert, S.S., Calon, F., Morin, F., Julien, J., Gratuze, M., Neurobiology of Aging, 2016, 10.1016/j.neurobiolaging.2016.07.016
  • Molecular biology: miRNAs in neurodegeneration, De Strooper, B., Hébert, S.S., Science, 2007, 10.1126/science.1148530
  • Tau hyperphosphorylation and deregulation of calcineurin inmousemodels of Huntington's disease, Planel, E., Samadi, P., Parker, J.A., Cicchetti, F., Hébert, S.S., Whittington, R.A., Bissonnette, S., Poitras, i., Bezeau, F., Goupil, C., Dickler, M., Morin, F., Milot-Rousseau, P., Cisbani, G., Julien, C., Noël, A., Gratuze, M., Human Molecular Genetics, 2015, 10.1093/hmg/ddu456
  • Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes, De Strooper, B., Müller, U., Filippov, M.A., Derks, C., Craessaerts, K., Tolia, A., Serneels, L., Hébert, S.S., EMBO Reports, 2006, 10.1038/sj.embor.7400704
  • Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice, Planel, E., Hébert, S.S., Mathews, P.M., Amrani, A., Gaudreau, S., Petry, F.R., Bretteville, A., Morin, F., Julien, C., Marcouiller, F., El Khoury, N.B., Papon, M.-A., Diabetes, 2013, 10.2337/db12-0187
  • The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the golgi/endosomes protein network, Faure, R.L., Landry, C.R., Kelly, I., Hébert, S.S., Fortier, S., Collard-Simard, G., Boutchueng-Djidjou, M., Molecular and Cellular Proteomics, 2015, 10.1074/mcp.M114.047159

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/04
  • Mohamed Amir Kezai - Post-doctorat - En cours
  • Nasim Eskandari - Doctorat - En cours
  • Gabriel Boulay - Maîtrise avec mémoire - En cours
  • Mohamed Lala Bouali - Doctorat - En cours
  • Véronique Lévesque - Maîtrise avec mémoire - En cours
  • Boutheyna Khelaifia - Doctorat - En cours
  • Rémi Keraudren - Maîtrise avec mémoire - 2023/09
  • Behnaz Nateghi - Doctorat - 2024/05
  • Malia Bouaziz - Maîtrise avec mémoire - 2025/01

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Neurobiologie — Neurosciences

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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