Sébastien Thériault

Variability of High-Sensitivity Troponin T Concentrations in Emergency Settings, Thériault, S., Douville, P., American Journal of Clinical Pathology, 2018, 10.1093/ajcp/aqy025

Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis, Vol, S., Tichet, J., Rakotozafy, F., Moreau, J.G., Lantieri, O., Cailleau, M., Caces, E., Born, C., Cogneau, J., Rancière, F., Froguel, P., Bonnefond, A., Bonnet, F., Marre, M., Fumeron, F., Girault, A., Alhenc-Gelas, F., Eschwège, E., Ducimetière, P., Balkau, B., Schott, J.-J., Bossé, Y., Le Tourneau, T., Mathieu, P., Pibarot, P., Dagenais, F., Roussel, R., Probst, V., Baufreton, C., Philippe Verhoye, J., Roussel, J.-C., Fellah, I., Karakachoff, M., Charpentier, E., Bonnaud, S., Baron, E., Lecointe, S., Boureau, A.-S., Arsenault, B.J., Clavel, M.-A., Lamontagne, M., Simonet, F., Li, Z., Rigade, S., Gaudreault, N., Capoulade, R., Le Scouarnec, S., Messika-Zeitoun, D., Dina, C., Thériault, S., Schott, J.-J., Bossé, Y., Le Tourneau, T., Mathieu, P., Pibarot, P., Dagenais, F., Redon, R., Roussel, R., Probst, V., Baufreton, C., Philippe Verhoye, J., Roussel, J.-C., Fellah, I., Charpentier, E., Karakachoff, M., Bonnaud, S., Baron, E., Lecointe, S., Boureau, A.-S., Arsenault, B.J., Clavel, M.-A., Lamontagne, M., Simonet, F., Li, Z., Rigade, S., Gaudreault, N., Capoulade, R., Le Scouarnec, S., Messika-Zeitoun, D., Dina, C., Thériault, S., Circulation: Genomic and Precision Medicine, 2019, 10.1161/CIRCGEN.119.002617

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation, Ellinor, P.T., Lubitz, S.A., Lunetta, K.L., Tanaka, T., Benjamin, E.J., Heckbert, S.R., Chasman, D.I., Kääb, S., Roden, D.M., Alonso, A., Gudnason, V., Felix, S.B., Chung, M.K., Stricker, B.H., Lehtimäki, T., März, W., Rotter, J.I., Hayward, C., Jukema, J.W., Pereira, A., Kathiresan, S., Lokki, M.-L., Van Der Harst, P., Rosand, J., Conen, D., Laurikka, J., Loos, R.J.F., Melander, O., Kooperberg, C., Ingelsson, E., Dichgans, M., Guo, X., Lin, H.J., Sinner, M.F., Jöckel, K.-H., Völker, U., Franco, O.H., Hofman, A., Uitterlinden, A.G., Soliman, E.Z., Sotoodehnia, N., Huang, P.L., Almgren, P., Heilmann-Heimbach, S., Macfarlane, P.W., Shaffer, C., Newton-Cheh, C., Darbar, D., Kriebel, J., Denny, J.C., Heeringa, J., Hamsten, A., Orho-Melander, M., Nikus, K., Pedersen, N.L., Vlachopoulou, E., Hocking, L.J., Porteous, D., Magnusson, P.K., Campbell, A., Taylor, K.D., Anderson, C.D., Rost, N., Lannfelt, L., Eisele, L., Boerwinkle, E., Li, M., Sandhu, R.K., Chen, Y.-D.I., Chen, L.Y., Delgado, G., Reiner, A.P., Ford, I., Morris, A.P., Eskola, M., Huang, J., Wong, J.A., Lindgren, C.M., Hernesniemi, J., Bottinger, E.B., Lu, Y., Scott, S.A., Lind, L., Smith, B.H., Peters, A., Mansur, A.J., Risch, L., Kähönen, M., Arendt, M., Krieger, J.E., Lichtner, P., Waldenberger, M., Bartz, T.M., Haessler, J., Padmanabhan, S., Shoemaker, M.B., Launer, L.J., Harris, T.B., Magnani, J.W., Ridker, P.M., Psaty, B.M., Perz, S., Bis, J.C., Van Wagoner, D.R., Smith, J.D., Kubo, M., Siland, J.E., Verweij, N., Hagemeijer, Y.P., Kamatani, Y., Paré, G., Worrall, B.B., Yang, Q., Chauhan, G., Debette, S., Hopewell, J.C., Sun, A., Shah, S.H., Rader, D.J., Deo, R., Clauss, S., Weng, L.-C., Choi, S.H., Teumer, A., Weiss, S., Radmanesh, F., Yao, J., Thériault, S., Aeschbacher, S., Sinisalo, J., Perez, M., Horimoto, A.R.V.R., Malik, R., Seppälä, I., Lyytikäinen, L.-P., Kleber, M.E., Schurmann, C., Gustafsson, S., Huffman, J., Trompet, S., Dörr, M., Niemeijer, M.N., Brody, J.A., Smith, J.G., Müller-Nurasyid, M., Weeke, P.E., Low, S.-K., Bihlmeyer, N.A., Klarin, D., Li, M., Tucker, N.R., Chaffin, M., Albert, C.M., Smith, A.V., Arking, D.E., Lin, H., Barnard, J., Geelhoed, B., Yin, X., Roselli, C., Rienstra, M., Christophersen, I.E., Nature Genetics, 2017, 10.1038/ng.3843

Early prediction of gestational diabetes: A practical model combining clinical and biochemical markers, Forest, J.-C., Girouard, J., Massé, J., Giguère, Y., Thériault, S., Clinical Chemistry and Laboratory Medicine, 2016, 10.1515/cclm-2015-0537

Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids with Aortic Stenosis, Thanassoulis, G., Engert, J.C., Lathrop, M., Rader, D.J., Smith, J.G., Wells, Q.S., Bossé, Y., Söderberg, S., Clarke, R., Post, W.S., Tsai, M.Y., Rotter, J.I., O'Donnell, C.J., Gudnason, V., Mathieu, P., Arsenault, B.J., Pibarot, P., Wareham, N.J., Boekholdt, S.M., Stark, K.D., Damrauer, S.M., Harris, W.S., Larson, M.G., Vasan, R.S., Nguyen, A., Budoff, M.J., Whitmer, R.A., Ranatunga, D.K., Johansson, B., Näslund, U., Ljungberg, J., Dufresne, L., Sonestedt, E., Rong, J., Shaffer, C.M., Levinson, R.T., Zhang, R., Steffen, B., Munter, H.M., Thériault, S., Martinsson, A., Ambikkumar, A., Burr, H.A., Small, A.M., Cairns, B.J., Chen, H.Y., JAMA Cardiology, 2020, 10.1001/jamacardio.2020.0246

A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and drug candidates for human healthspan extension, Arsenault, B.J., Mathieu, P., Thériault, S., Bossé, Y., Ghodsian, N., Mitchell, P., Li, Z., Couture, C., Bourgault, J., Pelletier, W., Perrot, N., medRxiv, 2020, 10.1101/2020.07.06.20147520

Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses, Arsenault, B.J., Boekholdt, S.M., Clavel, M.-A., Thériault, S., Mathieu, P., Stroes, E.S.G., Pibarot, P., Bossé, Y., Wareham, N.J., Couture, C., Bourgeois, R., Perrot, N., Manikpurage, H., Kaiser, Y., Guertin, J., Circulation: Genomic and Precision Medicine, 2021, 10.1161/CIRCGEN.120.003271

Mendelian randomization analysis identifies blood tyrosine levels as a biomarker of non-alcoholic fatty liver disease, Arsenault, B.J., Tchernof, A., Esko, T., Thériault, S., Vohl, M.-C., Corbeil, J., Julien, F., Mathieu, P., Mitchell, P.L., Couture, C., Manikpurage, H.D., Gagnon, É., Bourgault, J., Abner, E., Ghodsian, N., Brière, F., Taba, N., Maltais-Payette, I., Gobeil, É., medRxiv, 2021, 10.1101/2021.11.26.21266879

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders, Elliott, P., Schumann, G., Desrivières, S., Rothenfluh, A., Matthews, P., Bell, J.D., Tzoulaki, I., Levy, D., Wilson, J.F., Weir, D.R., Verweij, N., Spector, T.D., Scott, L.J., Samani, N.J., Rudan, I., Raitakari, O.T., Psaty, B.M., Penninx, B.W.J., Oldehinkel, A.J., Martin, N.G., Morrison, A.C., Mohlke, K.L., McIntosh, A.M., Lehtimäki, T., Lahti, J., Laakso, M., Kuusisto, J., Kühne, M., Kardia, S.L.R., Kähönen, M., Jarvelin, M.-R., Heath, A.C., Hayward, C., Hartman, C.A., der Harst, P.V., Guo, X., Grabe, H.J., Eriksson, J.G., Conen, D., Campbell, H., Boehnke, M., Blakemore, A.I., Veijola, J., Snieder, H., Rotter, J.I., Risch, L., Männikkö, M., Liu, C., Auvinen, J., Arking, D.E., Zhao, W., Yu, B., Yao, J., Wood, A., Whitfield, J.B., Vangipurapu, J., Thériault, S., Tuominen, S., Teumer, A., Stančáková, A., Smith, J.A., Ratliff, S.M., Porteous, D., Polasek, O., Perälä, M.-M., Nolte, I.M., Nelson, C.P., Milaneschi, Y., Mangino, M., Lyytikäinen, L.-P., Lind, P.A., Lemaitre, R.N., Joshi, P.K., Kentistou, K.A., Homuth, G., Jackson, A.U., Faul, J.D., Dimou, N., Clarke, T.-K., Brody, J.A., Brown, M.R., Braund, P.S., Baumeister, S.E., Bartz, T.M., Aeschbacher, S., Elliott, J., Karaman, I., Yiorkas, A.M., Koskeridis, F., Suzuki, H., Pazoki, R., Butts, A.R., Blakeley, P., Ntritsos, G., Chu, C., Gao, H., Evangelou, E., bioRxiv, 2018, 10.1101/453332

Relationships of Measured and Genetically Determined Height with the Cardiac Conduction System in Healthy Adults, Conen, D., Paré, G., Albert, C.M., Risch, L., Risch, M., Blum, S., Krisai, P., Bernet, S., Aeschbacher, S., Bossard, M., Thériault, S., Kofler, T., Circulation: Arrhythmia and Electrophysiology, 2017, 10.1161/CIRCEP.116.004735

Clinical experience with SERPINA1 DNA sequencing to detect alpha-1 antitrypsin deficiency, Bossé, Y., Thériault, S., Racine, C., Gaudreault, N., Maltais, F., Annals of the American Thoracic Society, 2018, 10.1513/AnnalsATS.201708-694RL

Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights, Yohan Bossé, Philippe Joubert, Patrick Mathieu, Sébastien Thériault, Patrice Desmeules, Nathalie Gaudreault, Dominique K. Boudreau, Victoria Saavedra Armero, Sébastien Renaut, PLOS Genetics, 2024, 10.1371/journal.pgen.1011301

Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study, Benoit J. Arsenault, Patrick Mathieu, Sébastien Thériault, Nooshin Ghodsian, Tõnu Esko, Nele Taba, Erik Abner, Hasanga D. Manikpurage, Patricia L. Mitchell, Eloi Gagnon, Journal of Translational Medicine, 2023, 10.1186/s12967-022-03799-5

Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography, Arsenault, B.J., Clavel, M.-A., Pibarot, P., Thanassoulis, G., Tsimikas, S., Dweck, M.R., Mathieu, P., Couture, P., Witztum, J.L., Bossé, Y., Thériault, S., Engert, J.C., Nadeau, M., Guimond, J., Tessier, M., Trottier, M., Bourgeois, R., Chen, H.Y., Shen, M., Tastet, L., Poulin, A., Perrot, N., Després, A.-A., CJC Open, 2019, 10.1016/j.cjco.2019.03.004

Oximetry neither to prescribe long-term oxygen therapy nor to screen for severe hypoxaemia, Maltais, F., Bernatchez, H.J., Sériès, F., Bernard, S., St-Pierre, B., Thériault, S., Lacasse, Y., ERJ Open Research, 2021, 10.1183/23120541.00272-2021

Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis, Benoit J. Arsenault, Sébastien Thériault, Patrick Mathieu, Aida Eslami, Arnaud Girard, Audrey Paulin, Hasanga D. Manikpurage, Circulation: Genomic and Precision Medicine, 2023, 10.1161/CIRCGEN.123.004137

Validation of early risk-prediction models for gestational diabetes based on clinical characteristics, Giguère, Y., Massé, J., Forest, J.-C., Thériault, S., Diabetes Research and Clinical Practice, 2014, 10.1016/j.diabres.2013.12.009

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis, Bossé, Y., Mathieu, P., Pibarot, P., Dagenais, F., Capoulade, R., Clavel, M.-A., Messika-Zeitoun, D., Lamontagne, M., Gaudreault, N., Thériault, S., bioRxiv, 2017, 10.1101/184945

Greater adherence to the 2019 Canada’s Food Guide recommendations on healthy food choices reduces the risk of cardiovascular disease in adults: a prospective analysis of UK Biobank data, Benoît Lamarche, Benoît J Arsenault, Sébastien Thériault, Hasanga D Manikpurage, Didier Brassard, The American Journal of Clinical Nutrition, 2022, 10.1093/ajcn/nqac256

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney, Ehret, G.B., Caulfield, M.J., Snieder, H., Tobin, M.D., Levy, D., Morris, A.P., Knight, J., Chakravarti, A., Chasman, D.I., Elliott, P., Munroe, P.B., Newton-Cheh, C., Bochud, M., Franco, O.H., Boomsma, D.I., Ingelsson, E., Metspalu, A., Palmas, W., Strachan, D.P., Jukema, J.W., James, A., Rettig, R., Psaty, B.M., Peters, A., Gudnason, V., van Duijn, C.M., Lehtimäki, T., Zhao, J.H., Schmidt, H., Wilson, J.F., Perola, M., Toniolo, D., Salomaa, V., Hartman, C.A., Watkins, H., Liu, Y., Laan, M., Gasparini, P., Hicks, A.A., Scott, R.A., Keavney, B.D., Elosua, R., Ciullo, M., Deary, I.J., Knekt, P., Gyllensten, U., Tuomilehto, J., Samani, N.J., Vitart, V., Lindgren, C.M., Kooner, J.S., Hayward, C., Girotto, G., Starr, J.M., Polasek, O., Loos, R.J.F., Vergnaud, A.-C., Palmer, C.N.A., van der Harst, P., Zeggini, E., Spector, T.D., Mook-Kanamori, D.O., Debette, S., Sever, P., John, A., Conen, D., Thériault, S., Yao, J., Wright, A.F., Willemsen, G., Wild, S., Vollenweider, P., Vöker, U., Uitterlinden, A.G., Tzourio, C., Tzoulaki, I., Thom, S., Taylor, K.D., Swertz, M., Sundström, J., Stott, D.J., Stanton, A., Sorice, R., Siscovick, D., Shields, D.C., Seelen, M.A., Scott, R., Schmidt, R., Sala, C.F., Sarin, A.-P., Pierre, A.S., Saba, Y., Rudan, I., Rotter, J.I., Robino, A., Ripatti, S., Riese, H., Ridker, P.M., Rice, K., Ren, M., Raitakari, O.T., Pramstaller, P.P., Poulter, N., Penninx, B.W.J.H., Pattie, A., Paré, G., Palotie, A., Padmanabhan, S., Org, E., Oldehinkel, A.J., Oostra, B.A., Nutile, T., Nguyen, Q.T., Nandakumar, P., Munson, P.J., Morrison, A.C., Morris, A.D., Morgan, A., Milaneschi, Y., Mifsud, B., Menni, C., Mamasoula, C., Mach, F., Lind, L., Lin, L., Liewald, D.C.M., Lehne, B., Larson, M., Launer, L.J., Langenberg, C., Koskinen, S., Kolcic, I., Khaw, K.-T., Kathiresan, S., Kähönen, M., Jula, A., Jousilahti, P., Johnson, A.D., Johansson, Å., Hui, J., Jarvelin, M.-R., Holliday, E.G., Hofman, A., Harris, T.B., Hamsten, A., Gow, A.J., Giulianini, F., Gieger, C., Giedraitis, V., Gao, H., Frånberg, M., Ferreira, T., Farrall, M., Dörr, M., Doney, A.S.F., Demirkale, Y., Deelen, J., de Mutsert, R., de Geus, E.J., Davies, G., Damman, J.J., Cordell, H.J., Connell, J., Collins, F., Cocca, M., Chambers, J.C., Campbell, H., Brumat, M., Brown, M., Braund, P.S., Bottinger, E.P., Boehnke, M., Blake, T., Beilby, J., Batini, C., Barnes, M.R., Barbieri, C.M., Abedi, M., Abecasis, G., Oldmeadow, C., Chauhan, G., Li-Gao, R., Campbell, A., Prins, B.P., Mangino, M., de Borst, M.H., Shah, N., Evangelou, E., Lu, Y., Zemonik, T., Harris, S.E., Gandin, I., Marten, J., Zhang, W., Huffman, J.E., Nelson, C.P., Jackson, A.U., Enroth, S., Niiranen, T., Lopez, L.M., Ruggiero, D., Marrugat, J., Ayers, K.L., Del Greco, F., Luan, J., Vuckovic, D., Sõber, S., Nalls, M.A., Goel, A., Traglia, M., Havulinna, A.S., Kristiansson, K., Joshi, P.K., Hofer, E., Wareham, N.J., Mahajan, A., Lyytikäinen, L.-P., Amin, N., Nolte, I.M., Smith, A.V., Bis, J.C., Ried, J.S., Teumer, A., Shrine, N., Trompet, S., Kutalik, Z., Guo, X., Hwang, S.-J., Arking, D.E., Esko, T., Strawbridge, R.J., Hottenga, J.-J., Verwoert, G.C., Rose, L.M., Warren, H.R., Cabrera, C.P., O'Reilly, P., Erzurumluoglu, A.M., van der Most, P.J., Joehanes, R., Jansen, R., Vaez, A., Wain, L.V., bioRxiv, 2017, 10.1101/110833

A false-positive troponin assay leading to the misdiagnosis of myopericarditis,Résultat de troponine faux positif à l'origine d'un diagnostic erroné de myopéricardite, Steinberg, C., Thériault, S., Turgeon, P.Y., Laguë, M., CMAJ. Canadian Medical Association Journal, 2022, 10.1503/cmaj.211842-f

Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targets, Benoit J. Arsenault, Patrick Mathieu, André Tchernof, Tõnu Esko, Marie-Claude Vohl, Sébastien Thériault, Dipender Gill, Erik Abner, Jérôme Bourgault, Arnaud Girard, Eloi Gagnon, 2023, 10.1101/2023.12.05.23299567

The journey towards identification of actionable molecular pathways in calcific aortic valve stenosis, Yohan Bossé, Patrick Mathieu, Sébastien Thériault, European Heart Journal, 2023, 10.1093/eurheartj/ehad134

Identification of circulating proteins associated with blood pressure using Mendelian randomization, Paré, G., Gerstein, H., Hess, S., Chong, M., Sjaarda, J., Thériault, S., Circulation: Genomic and Precision Medicine, 2020, 10.1161/CIRCGEN.119.002605

Elevated Lipoprotein(a) and Risk of Atrial Fibrillation: An Observational and Mendelian Randomization Study, Paré, G., Pigeyre, M., Lanktree, M.B., Bossé, Y., Roberts, J.D., Thériault, S., Conen, D., Perrot, N., Narula, S., Chong, M., Mohammadi-Shemirani, P., Journal of the American College of Cardiology, 2022, 10.1016/j.jacc.2022.02.018

PALMD as a novel target for calcific aortic valve stenosis, Thériault, S., Mathieu, P., Bossé, Y., Current Opinion in Cardiology, 2019, 10.1097/HCO.0000000000000605

Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population, Conen, D., Paré, G., Risch, L., Mueller, C., Risch, M., Todd, J., Estis, J., Kunz, S., von Rotz, M., Schoen, T., Aeschbacher, S., Thériault, S., Bossard, M., Clinical Research in Cardiology, 2017, 10.1007/s00392-016-1026-5

Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank, Bossé, Y., Thériault, S., Mathieu, P., Boulet, L.-P., Laviolette, M., Côté, A., Godbout, K., Labbé, C., Hao, K., Nickle, D.C., Sin, D.D., Timens, W., van den Berge, M., Obeidat, M., Joubert, P., Gaudreault, N., Lamothe, J., Eslami, A., Bérubé, J.-C., Chignon, A., Bon-Baret, V., Li, Z., Valette, K., Communications Biology, 2021, 10.1038/s42003-021-02227-6

Genetic analysis of over one million people identifies 535 novel loci for blood pressure., Caulfield, M.J., Elliott, P., Wain, L.V., Barnes, M.R., Tzoulaki, I., Psaty, B.M., Edwards, T.L., O’Donnell, C.J., Hung, A.M., Metspalu, A., Brown, M.J., Zeggini, E., Wareham, N.J., van der Harst, P., Spector, T.D., Sever, P., Scott, R.J., Scott, R.A., Risch, L., Munroe, P.B., Palmer, C.N.A., Mook-Kanamori, D.O., Melander, O., Langenberg, C., Lakatta, E.G., Laakso, M., Howson, J.M.M., Hayward, C., Danesh, J., Cucca, F., Conen, D., Chasman, D., Butterworth, A.S., Attia, J.R., Zhang, W., Zemunik, T., Yao, J., Wright, A.F., Wilson, J.F., Willemsen, G., Wild, S.H., Watkins, H., Vuckovic, D., Vollenweider, P., Völker, U., Vitart, V., Verwoert, G.C., Vergnaud, A.-C., van Duijn, C.M., van der Most, P.J., Vaez, A., Uitterlinden, A.G., Tzourio, C., Tuomilehto, J., Trompet, S., Traglia, M., Toniolo, D., Tobin, M.D., Teumer, A., Taylor, K.D., Swertz, M.A., Sundström, J., Strawbridge, R.J., Strachan, D.P., Stott, D.J., Starr, J.M., Sorice, R., Sõber, S., Snieder, H., Smith, A.V., Siscovick, D., Shrine, N., Schmidt, H., Schmidt, R., Sarin, A.-P., Samani, N.J., Salomaa, V., Sala, C.F., Saba, Y., Ruggiero, D., Rudan, I., Rotter, J.I., Rose, L.M., Robino, A., Ripatti, S., Riese, H., Ried, J.S., Ridker, P.M., Rice, K., Rettig, R., Ren, M., Raitakari, O.T., Tri, N.Q., Pramstaller, P.P., Polasek, O., Peters, A., Perola, M., Penninx, B.W.J.H., Pattie, A., Palotie, A., Palmas, W., Padmanabhan, S., Org, E., O'Reilly, P.F., Oostra, B.A., Oldehinkel, A.J., Nutile, T., Nolte, I.M., Niiranen, T., Newton-Cheh, C., Nelson, C.P., Nandakumar, P., Nalls, M.A., Munson, P.J., Morrison, A.C., Morris, A.P., Morgan, A., Milaneschi, Y., Marten, J., Marrugat, J., Mamasoula, C., Mahajan, A., Lyytikäinen, L.-P., Lu, Y., Lopez, L.M., Loos, R.J.F., Liu, Y., Lindgren, C.M., Lind, L., Lin, L., Liewald, D.C.M., Levy, D., Lehtimäki, T., Lehne, B.C., Launer, L.J., Larson, M., Laan, M., Kutalik, Z., Kristiansson, K., Koskinen, S., Kooner, J.S., Kolcic, I., Knight, J., Knekt, P., Khaw, K.-T., Keavney, B.D., Kathiresan, S., Kähönen, M., Jula, A., Wouter Jukema, J., Jousilahti, P., Joshi, P.K., Johnson, A.D., Johansson, Å., Joehanes, R., Jarvelin, M.-R., Jansen, R., James, A., Ingelsson, E., Hwang, S.-J., Huffman, J.E., Hottenga, J.-J., Hofman, A., Hofer, E., Hicks, A.A., Havulinna, A.S., Hartman, C.A., Harris, S.E., Harris, T.B., Hamsten, A., Gyllensten, U., Guo, X., Gudnason, V., Gow, A.J., Goel, A., Girotto, G., Gieger, C., Giedraitis, V., Gasparini, P., Gandin, I., Franco, O.H., Frånberg, M., Ferreira, T., Mesut Erzurumluoglu, A., Enroth, S., Elosua, R., Ehret, G.B., Dörr, M., Demirkale, C.Y., Del Greco, F.M., Deelen, J., Deary, I.J., de Geus, E.J., de Borst, M.H., Davies, G., Cordell, H.J., Collins, F., Cocca, M., Ciullo, M., Chauhan, G., Chambers, J.C., Chakravarti, A., Campbell, H., Campbell, A., Brumat, M., Braund, P.S., Bottinger, E.P., Boomsma, D.I., Boerwinkle, E., Boehnke, M., Bochud, M., Blake, T., Bis, J.C., Batini, C., Barbieri, C.M., Ayers, K.L., Arking, D.E., Amin, N., Abecasis, G., Thom, S., Stanton, A., Shields, D.C., Poulter, N.R., Paré, G., Noordam, R., Morris, A.D., Menni, C., Farrall, M., Doney, A.S.F., de Mutsert, R., Connell, J., Amouyel, P., Zhao, J.-H., Willems, S.M., Verweij, N., Thériault, S., Surendran, P., Shah, N., Sargurupremraj, M., Qian, Y., Prins, B., Oldmeadow, C., Mangino, M., Luan, J., Lin, W.-Y., Li-Gao, R., Jackson, A.U., Holliday, E.G., Giulianini, F., Ding, J., Debette, S., Boutin, T., Almgren, P., Milani, L., Mägi, R., Esko, T., Kovesdy, C.P., Tsao, P.S., Wilson, P.W.F., Michael Gaziano, J., Cho, K., Sun, Y.V., Velez-Edwards, D.R., Giri, A., Hellwege, J.N., Tzanis, E., Witkowska, K., Evangelou, M., Ng, F.L., Karaman, I., Cabrera, C.P., Dimou, N., Ntritsos, G., Gao, H., Pazoki, R., Mifsud, B., Mosen-Ansorena, D., Warren, H.R., Evangelou, E., bioRxiv, 2017, 10.1101/198234

A Multivariable Mendelian Randomization Analysis Disentangling The Causal Relations Between Abdominal Obesity, Non-Alcoholic Fatty Liver Disease and Cardiometabolic Diseases, Arsenault, B., Thériault, S., Tchernof, A., Vohl, M.-C., Després, J.-P., Ghodsian, N., Mitchell, P., Esko, T., Taba, N., Abner, E., Maltais-Payette, I., Manikpurage, H., Bourgault, J., Gobeil, É., Pelletier, W., Gagnon, E., ResearchSquare, 2022, 10.21203/rs.3.rs-1336425

Sex-specific impact of body weight on atherosclerotic cardiovascular disease incidence in individuals with and without ideal cardiovascular health, Benoit J. Arsenault, Sébastien Thériault, Jean-Pierre Després, Hasanga D. Manikpurage, Audrey Paulin, 2023, 10.1101/2023.01.16.23284627

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis, Bossé, Y., Mathieu, P., Pibarot, P., Dagenais, F., Capoulade, R., Clavel, M.-A., Messika-Zeitoun, D., Boulanger, M.-C., Rosa, M., Lamontagne, M., Gaudreault, N., Thériault, S., Nature Communications, 2018, 10.1038/s41467-018-03260-6

Genetic risk score for intracranial aneurysms to predict aneurysmal subarachnoid hemorrhage and identify associations with patient characteristics, Kamatani, Y., Woo, D., Werring, D.J., Broderick, J.P., Slowik, A., Pera, J., Worrall, B.B., Rinkel, G.J.E., Debette, S., Tatlisumak, T., Sargurupremraj, M., Dichgans, M., Malik, R., Walters, R.G., Bourcier, R., Palotie, A., Nyholt, D.R., Chasman, D.I., Olesen, J., Neale, B.M., Daly, M.J., Eriksson, N., Stefansson, K., Smith, G.D., Boomsma, D.I., Zwart, J.-A., van den Maagdenberg, A.M.J.M., Wessman, M., Dichgans, M., Belin, A.C., Ferrari, M.D., Strachan, D.P., Kubisch, C., Metspalu, A., Järvelin, M.-R., Spector, T., Ikram, M.A., Raitakari, O., Aromaa, A.J., Kaprio, J., Werge, T., Hansen, T.F., Christensen, A.F., Esserlind, A.-L., Göbel, H., Milani, L., Mihailov, E., Männikkö, M., Nielsen, C.S., Stubhaug, A., Pedersen, L.M., Cherkas, L., van Duijn, C.M., Hofman, A., Uitterlinden, A.G., Loehrer, E., Heikkilä, K., Salomaa, V., Eriksson, J.G., 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Frameshift mutation in the APOA5 gene causing hypertriglyceridemia in a Pakistani family: Management and considerations for cardiovascular risk, Paré, G., Morrison, K.M., Lali, R., Chong, M., Don-Wauchope, A., Thériault, S., Journal of Clinical Lipidology, 2016, 10.1016/j.jacl.2016.07.009

Circulating Galectin-3 Levels Are Not Associated with Nonalcoholic Fatty Liver Disease: A Mendelian Randomization Study, Arsenault, B.J., Thériault, S., Mitchell, P.L., Couture, C., Gobeil, É., Ghodsian, N., Perrot, N., Tremblay, M., Journal of Clinical Endocrinology and Metabolism, 2021, 10.1210/clinem/dgab144

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction, Munroe, P.B., Lubitz, S.A., Jamshidi, Y., Ellinor, P.T., Stefansson, K., Tinker, A., Benjamin, E.J., Thorsteinsdottir, U., Thorolfsdottir, R.B., Thorleifsson, G., Sulem, P., Holm, H., Gudbjartsson, D.F., Arnar, D.O., Van Duijvenboden, S., Ramirez, J., Orini, M., Lambiase, P.D., Yldau van der Ende, M., Abdullah Said, M., Assa, S., Stilp, A., Seyerle, A.A., Laurie, C.C., Kerr, K.F., Gogarten, S.M., Avery, C.L., Soliman, E.Z., Ehret, G.B., Boerwinkle, E., Arking, D.E., Alonso, A., Whitsel, E.A., Reiner, A.P., Peters, U., Kooperberg, C., Jackson, R.D., Haessler, J., van den Berg, M.E., Uitterlinden, A., Stricker, B.H., Smith, B.H., Porteous, D.J., Murray, A.D., Lunetta, K.L., Newton-Cheh, C.H., Lin, H., Levy, D., Tarasov, K.V., Qian, Y., Lakatta, E.G., Ding, J., Cucca, F., Noordam, R., Mook-Kanamori, D.O., Maan, A.C., de Mutsert, R., Yao, J., Taylor, K.D., Rotter, J.I., Lin, H.J., Heckbert, S.R., Guo, X., Salomaa, V., Sääksjärvi, K., Jula, A., Havulinna, A.S., Weiss, S., Völker, U., Felix, S.B., Dörr, M., Trompet, S., Macfarlane, P.W., Wouter Jukema, J., Ford, I., Pramstaller, P.P., Pattaro, C., Fuchsberger, C., De Grandi, A., Sotoodehnia, N., Rice, K., Psaty, B.M., Brody, J.A., Bis, J.C., Biggs, M.L., Gustav Smith, J., Benjamin Shoemaker, M., Roden, D.M., Olesen, M., London, B., Fatkin, D., Cutler, M.J., Strauch, K., Sinner, M.F., Schramm, K., Kääb, S., Verweij, N., van der Harst, P., van de Vegte, Y.J., Rienstra, M., Spector, T.D., Mangino, M., Waldenberger, M., Peters, A., Müller-Nurasyid, M., Meitinger, T., Wilson, J., Mei, H., Correa, A., Preuss, M.H., Nadkarni, G.N., Loos, R.J.F., Bottinger, E.P., Smith, A.V., Launer, L.J., Harris, T.B., Gudnason, V., Huang, P.L., van Duijn, C.M., Kors, J.A., Isaacs, A., Wilson, J.F., Joshi, P.K., Campbell, H., Barnes, C.L.K., Raitakari, O.T., Lyytikäinen, L.-P., Lehtimäki, T., Hutri-Kähönen, N., Thériault, S., Risch, L., Conen, D., Aeschbacher, S., Shuldiner, A.R., Ryan, K., O’Connell, J.R., Montasser, M.E., Padmanabhan, S., Dominiczak, A., Caulfield, M.J., Nikus, K., Mononen, N., Mishra, P.P., Kähönen, M., Ulivi, S., Sinagra, G., Samani, N.J., Riaz, M.B., Nelson, C.P., Sundström, J., Lindgren, C.M., Lind, L., Cook, J.P., Hicks, A.A., Gögele, M., Foco, L., Del Greco M, F., Morris, A.P., Mahajan, A., Ingelsson, E., Giedraitis, V., Tarazona-Santos, E., Souza, R.P., Ribeiro, A.L.P., Lima-Costa, M.F., Araujo, N.M., Rudan, I., Polasek, O., Kolcic, I., Boutin, T., Gasparini, P., Concas, M.P., Cranley, J.J., Marten, J., Hayward, C., Warren, H.R., Mifsud, B., Barnes, M.R., Roselli, C., Chaffin, M.D., Choi, S.H., Tucker, N.R., Sveinbjornsson, G., Hall, A.W., Cartwright, J.H., Weng, L.-C., Ntalla, I., Nature Communications, 2020, 10.1038/s41467-020-15706-x

Polygenic Contribution in Individuals with Early-Onset Coronary Artery Disease, Paré, G., Natarajan, M.K., Velianou, J.L., Chong, M., Lali, R., Thériault, S., Circulation: Genomic and Precision Medicine, 2018, 10.1161/CIRCGEN.117.001849

A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity, Mathieu, P., Thériault, S., Bossé, Y., Arsenault, B.J., Boulanger, M.-C., Li, Z., Chignon, A., Rosa, M., npj Genomic Medicine, 2019, 10.1038/s41525-019-0097-4

Long-Term Exposure to Elevated Lipoprotein(A) Levels Influences Human Longevity, Boekholdt, S.M., Thériault, S., Mathieu, P., Stroes, E.S.G., Pibarot, P., Bossé, Y., Wareham, N.J., Khaw, K.-T., Couture, C., Perrot, N., Kaiser, Y., Pelletier, W., Arsenault, B., SSRN, 2019, 10.2139/ssrn.3404259

Gene expression profiles for the identification of prevalent atrial fibrillation, Paré, G., Yusuf, S., Vincent, J., Raman, K., Whitlock, R., Thériault, S., Journal of the American Heart Association, 2017, 10.1161/JAHA.117.006057

Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease, Arsenault, B.J., Esko, T., Khera, A.V., Thériault, S., Tchernof, A., Vohl, M.-C., Mathieu, P., Bossé, Y., Mitchell, P.L., Couture, C., St-Amand, A., Bourgault, J., Gagnon, É., Manikpurage, H.D., Perrot, N., Haas, M.E., Taba, N., Gobeil, É., Emdin, C.A., Abner, E., Ghodsian, N., Cell Reports Medicine, 2021, 10.1016/j.xcrm.2021.100437

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium, Lubitz, S.A., Albert, C.M., Felix, S.B., Stricker, B.H., Jukema, J.W., Van Der Harst, P., Rotter, J.I., Smith, J.G., März, W., Lehtimäki, T., Benjamin, E.J., Heckbert, S.R., Chung, M.K., Roden, D.M., Conen, D., Arking, D.E., Gudnason, V., Kääb, S., Rose, L.M., Teumer, A., Völker, U., Uitterlinden, A.G., Franco, O.H., Heeringa, J., Ford, I., Macfarlane, P., Verweij, N., Geelhoed, B., Ellinor, P.T., Christophersen, I.E., Guo, X., Yao, J., Engström, G., Melander, O., Delgado, G.E., Nikus, K., Kähönen, M., Taylor, K.D., Sotoodehnia, N., Psaty, B.M., Smith, J.D., Van Wagoner, D.R., Shoemaker, M.B., Denny, J.C., Teixeira, P.L., Paré, G., Alonso, A., Soliman, E.Z., Harris, T.B., Launer, L.J., Waldenberger, M., Sinner, M.F., Chasman, D.I., Klarin, D., Dörr, M., Krijthe, B.P., Trompet, S., Rienstra, M., Lin, H.J., Martinsson, A., Kleber, M.E., Lyytikäinen, L.-P., Bis, J.C., Barnard, J., Weeke, P.E., Thériault, S., Smith, A.V., Müller-Nurasyid, M., Lunetta, K.L., Weng, L.-C., Scientific Reports, 2017, 10.1038/s41598-017-09396-7

Genetic inhibition of PCSK9, atherogenic lipoprotein concentrations, and calcific aortic valve stenosis, Arsenault, B.J., Poggio, P., Thériault, S., Camera, M., Smith, J.G., Pibarot, P., Bossé, Y., Mathieu, P., Thanassoulis, G., Engert, J.C., Chen, H.Y., Dina, C., Wareham, N.J., Clavel, M.-A., Mass, E., Capoulade, R., Martinsson, A., Valerio, V., Boekholdt, S.M., Moschetta, D., Perrot, N., bioRxiv, 2019, 10.1101/560458

Absence of association between serum folate and preeclampsia in women exposed to food fortification., Forest, J.C., Bujold, E., Girouard, J., Lavoie, S.B., Massé, J., Giguère, Y., Thériault, S., Obstetrics and gynecology, 2013, 10.1097/aog.0b013e31829b2f7c

Soluble Fms-like tyrosine kinase-1 to placental growth factor ratio in mid-pregnancy as a predictor of preterm preeclampsia in asymptomatic pregnant women, Giguère, Y., Bujold, E., Massé, J., Thériault, S., Forest, J.-C., Clinical Chemistry and Laboratory Medicine, 2014, 10.1515/cclm-2013-0955

System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan, Patrick Mathieu, Yohan Bossé, Sébastien Thériault, Benoit J. Arsenault, Deborah Argaud, Zhonglin Li, Marie-Chloé Boulanger, Arnaud Chignon, Valentin Bon-Baret, Circulation: Genomic and Precision Medicine, 2021, 10.1161/CIRCGEN.120.003196

Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis, Mathieu, P., Bossé, Y., Thériault, S., Gosselin, D., Gaudreault, N., Rufiange, A., Li, Z., Mkannez, G., Bon-Baret, V., Devillers, R., Argaud, D., Boulanger, M.-C., Rosa, M., Chignon, A., iScience, 2021, 10.1016/j.isci.2021.102241

Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin, Devuyst, O., Hayward, C., Köttgen, A., Bochud, M., Wilson, J.F., Olinger, E., Wuehl, E., Conen, D., Ulivi, S., Girotto, G., Awadalla, P., Madore, F., Deary, I.J., Porteous, D.J., Polasek, O., Olden, M., Campbell, H., Bergmann, S., Schaefer, F., Aeschbacher, S., Sala, C., Concas, M.P., Bruat, V., Black, C., Kolcic, I., Corre, T., Cheng, Y., Wuttke, M., Eckardt, K.-U., Thériault, S., Robino, A., Cocca, M., Troyanov, S., Harris, S.E., Campbell, A., Huffman, J.E., Richmond, A., Marten, J., Lake, J., Schiano, G., Yoshifuji, A., Mariniello, M., Joseph, C.B., Journal of the American Society of Nephrology, 2022, 10.1681/ASN.2021040491

Screening for pre-eclampsia early in pregnancy: Performance of a multivariable model combining clinical characteristics and biochemical markers, Forest, J.-C., Rousseau, F., Lafond, J., Bujold, E., Thériault, S., Massé, J., Giguère, Y., BJOG: An International Journal of Obstetrics and Gynaecology, 2015, 10.1111/1471-0528.13050

A multivariable Mendelian randomization analysis disentangling the causal relations between abdominal obesity, non-alcoholic fatty liver disease and cardiometabolic diseases, Arsenault, B.J., Thériault, S., Tchernof, A., Vohl, M.-C., Després, J.-P., Ghodsian, N., Mitchell, P.L., Esko, T., Taba, N., Abner, E., Maltais-Payette, I., Manikpurage, H.D., Bourgault, J., Gobeil, É., Gagnon, É., Pelletier, W., medRxiv, 2021, 10.1101/2021.09.28.21264201

Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization, Munroe, P.B., Newton-Cheh, C., Mifsud, B., Sotoodehnia, N., Lambiase, P.D., Ramirez, J., Arking, D.E., Wilson, J.F., Verweij, N., van Duijn, C.M., van der Harst, P., Stricker, B., Rotter, J.I., Psaty, B.M., Peters, A., Pattaro, C., Padmanabhan, S., Orini, M., Olesen, M.S., O'Connell, J.R., Morris, A.P., Mook-Kanamori, D.O., Lubitz, S.A., Loos, R.J.F., Liu, Y., Lima-Costa, M.F., Lehtimäki, T., Kooperberg, C., Kanters, J.K., Kähönen, M., Kääb, S., Jukema, J.W., Järvelin, M.-R., Jamshidi, Y., Hayward, C., Grarup, N., Girotto, G., Gharib, S.A., Dörr, M., Cucca, F., Correa, A., Conen, D., Avery, C.L., Wilson, J.G., Whitsel, E.A., Weng, L.-C., Waldenberger, M., Völzke, H., Völker, U., Uitterlinden, A., Trompet, S., Tinker, A., Taylor, K.D., Tarasov, K., Strauch, K., Stoll, M., Soliman, E.Z., Sinner, M.F., Sinagra, G., Shoemaker, M.B., Shen, X., Schurmann, C., Schotten, U., Schlessinger, D., Risch, L., Rice, K.M., Ribeiro, A.L.P., Reiner, A.P., Raitakari, O.T., Preuss, M.H., Pramstaller, P.P., Porteous, D.J., Pittman, A., Pelliccione, G., Patton, K.K., Pare, G., Nikus, K., Navarro, P., Nauffal, V., Nauck, M., Morrison, A.C., Montasser, M.E., Mononen, N., Mitchell, R.N., Mishra, P.P., Mezzavilla, M., Meitinger, T., Mangino, M., MacFarlane, P.W., Liu, S., Linneberg, A., Lin, H.J., Lind, L., Lemaitre, R.N., Leal, T.P., Kors, J.A., Kavousi, M., Junttila, J., Jackson, R.D., Ikram, M.A., Hutri-Kähönen, N., Huikuri, H.V., Huang, P.L., Heckbert, S.R., Hansen, T., Guo, X., Graff, M., Graff, C., Gögele, M., Fuchsberger, C., Froguel, P., Felix, S.B., Ellinor, P.T., Ellervik, C., Ding, J., de Luca, A., de Grandi, A., Darbar, D., Cutler, M.J., Cocca, M., Catamo, E., Campbell, A., Boerwinkle, E., Bis, J.C., Andreasen, L., Alonso, A., Ahlberg, G., Aeschbacher, S., Raza, D., Yao, J., Warren, H.R., van Duijvenboden, S., Thériault, S., Tarazona-Santos, E., Ryan, K.A., Roselli, C., Richmond, A., Qian, Y., Nursyifa, C., Müller-Nurasyid, M., Moscati, A., Mei, H., Lin, H., Isaksen, J.L., Hines, O., Freudling, R., Evans, D.S., Cook, J.P., Bartz, T.M., Baldassari, A.R., Weiss, S., van den Berg, M.E., Concas, M.P., Repetto, L., Lyytikäinen, L.-P., Haessler, J., Benjamins, J.-W., Noordam, R., Salman, R., Brody, J.A., Ahmed, F., Foco, L., Duong, T., Isaacs, A., Lahrouchi, N., Young, W.J., medRxiv, 2021, 10.1101/2021.11.04.21265866

Lipoprotein Proteomics and Aortic Valve Transcriptomics Identify Biological Pathways Linking Lipoprotein(a) Levels to Aortic Stenosis, Benoit Arsenault, Yohan Bossé, Patrick Mathieu, Sébastien Thériault, Arnaud Droit, Philippe Pibarot, Marlys L. Koschinsky, Michael B. Boffa, Nathalie Gaudreault, Corey A. Scipione, Sylvie Bourassa, Clarisse Gotti, Patricia L. Mitchell, Arnaud Girard, Jakie Guertin, Nicolas Perrot, Audrey-Anne Despres, Jérôme Bourgault, Raphaëlle Bourgeois, Metabolites, 2021, 10.3390/metabo11070459

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways, Munroe, P.B., Newton-Cheh, C., Mifsud, B., Sotoodehnia, N., Lambiase, P.D., Ramirez, J., Arking, D.E., Wilson, J.F., Verweij, N., van Duijn, C.M., van der Harst, P., Stricker, B., Rotter, J.I., Psaty, B.M., Peters, A., Pattaro, C., Padmanabhan, S., Orini, M., Olesen, M.S., O’Connell, J.R., Morris, A.P., Mook-Kanamori, D.O., Lubitz, S.A., Loos, R.J.F., Liu, Y., Lima-Costa, M.F., Lehtimäki, T., Kooperberg, C., Kanters, J.K., Kähönen, M., Kääb, S., Jukema, J.W., Järvelin, M.-R., Jamshidi, Y., Hayward, C., Grarup, N., Girotto, G., Gharib, S.A., Dörr, M., Cucca, F., Correa, A., Conen, D., Avery, C.L., Wilson, J.G., Whitsel, E.A., Weng, L.-C., Waldenberger, M., Völzke, H., Völker, U., Uitterlinden, A., Trompet, S., Tinker, A., Taylor, K.D., Tarasov, K., Strauch, K., Stoll, M., Soliman, E.Z., Sinner, M.F., Sinagra, G., Shoemaker, M.B., Shen, X., Schurmann, C., Schotten, U., Schlessinger, D., Risch, L., Rice, K.M., Ribeiro, A.L.P., Reiner, A.P., Raitakari, O.T., Preuss, M.H., Pramstaller, P.P., Porteous, D.J., Pittman, A., Pelliccione, G., Pare, G., Patton, K.K., Nikus, K., Navarro, P., Nauffal, V., Nauck, M., Morrison, A.C., Montasser, M.E., Mononen, N., Mitchell, R.N., Mishra, P.P., Mezzavilla, M., Meitinger, T., Mangino, M., MacFarlane, P.W., Liu, S., Linneberg, A., Lind, L., Lin, H.J., Lemaitre, R.N., Leal, T.P., Kors, J.A., Kavousi, M., Junttila, J., Jackson, R.D., Ikram, M.A., Hutri-Kähönen, N., Huikuri, H.V., Huang, P.L., Heckbert, S.R., Hansen, T., Guo, X., Graff, M., Graff, C., Gögele, M., Fuchsberger, C., Froguel, P., Felix, S.B., Ellinor, P.T., Ellervik, C., Ding, J., De Luca, A., De Grandi, A., Darbar, D., Cocca, M., Cutler, M.J., Catamo, E., Campbell, A., Boerwinkle, E., Bis, J.C., Andreasen, L., Alonso, A., Ahlberg, G., Aeschbacher, S., Raza, D., Yao, J., Warren, H.R., van Duijvenboden, S., Thériault, S., Tarazona-Santos, E., Ryan, K.A., Roselli, C., Richmond, A., Qian, Y., Nursyifa, C., Moscati, A., Müller-Nurasyid, M., Mei, H., Lin, H., Isaksen, J.L., Hines, O., Freudling, R., Evans, D.S., Cook, J.P., Bartz, T.M., Baldassari, A.R., Weiss, S., van den Berg, M.E., Concas, M.P., Repetto, L., Lyytikäinen, L.-P., Haessler, J., Benjamins, J.-W., Noordam, R., Salman, R., Brody, J.A., Ahmed, F., Foco, L., Duong, T.V., Isaacs, A., Lahrouchi, N., Young, W.J., Nature Communications, 2022, 10.1038/s41467-022-32821-z

Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (Nature Genetics, (2018), 50, 10, (1412-1425), 10.1038/s41588-018-0205-x), Caulfield, M.J., Elliott, P., Wain, L.V., Barnes, M.R., Tzoulaki, I., Psaty, B.M., Edwards, T.L., O’Donnell, C.J., Hung, A.M., Metspalu, A., Brown, M.J., Newton-Cheh, C., Munroe, P.B., Levy, D., Zeggini, E., Wareham, N.J., van der Harst, P., Spector, T.D., Sever, P., Scott, R.J., Scott, R.A., Risch, L., Palmer, C.N.A., Mook-Kanamori, D.O., Melander, O., Langenberg, C., Lakatta, E.G., Laakso, M., Howson, J.M.M., Hayward, C., Danesh, J., Cucca, F., Conen, D., Chasman, D.I., Butterworth, A.S., Attia, J.R., Zhang, W., Zemunik, T., Yao, J., Wright, A.F., Wilson, J.F., Willemsen, G., Wild, S.H., Watkins, H., Vuckovic, D., Vollenweider, P., Völker, U., Vitart, V., Verwoert, G.C., Vergnaud, A.-C., van Duijn, C.M., van der Most, P.J., Vaez, A., Uitterlinden, A.G., Tzourio, C., Tuomilehto, J., Trompet, S., Traglia, M., Tomaszewski, M., Toniolo, D., Tobin, M.D., Teumer, A., Taylor, K.D., Swertz, M.A., Sundström, J., Strawbridge, R.J., Strachan, D.P., Stott, D.J., Starr, J.M., Sorice, R., Sõber, S., Snieder, H., Smith, A.V., Siscovick, D., Shrine, N., Schmidt, H., Schmidt, R., Sarin, A.-P., Samani, N.J., Salomaa, V., Sala, C.F., Saba, Y., Ruggiero, D., Rudan, I., Rotter, J.I., Rose, L.M., Robino, A., Ripatti, S., Riese, H., Ried, J.S., Ridker, P.M., Rice, K., Rettig, R., Ren, M., Raitakari, O.T., Nguyen, Q.T., Pramstaller, P.P., Polasek, O., Peters, A., Perola, M., Penninx, B.W.J.H., Pattie, A., Palotie, A., Palmas, W., Padmanabhan, S., Org, E., O’Reilly, P.F., Oostra, B.A., Oldehinkel, A.J., Nutile, T., Nolte, I.M., Niiranen, T., Nelson, C.P., Nandakumar, P., Nalls, M.A., Munson, P.J., Morrison, A.C., Morris, A.P., Morgan, A., Milaneschi, Y., Marten, J., Marrugat, J., Mamasoula, C., Mahajan, A., Lyytikäinen, L.-P., Lu, Y., Lopez, L.M., Loos, R.J.F., Liu, Y.M., Lindgren, C.M., Lind, L., Lin, L., Liewald, D.C.M., Lehtimäki, T., Lehne, B., Launer, L.J., Larson, M., Laan, M., Kutalik, Z., Kristiansson, K., Koskinen, S., Kooner, J.S., Kolcic, I., Knight, J., Knekt, P., Khaw, K.-T., Keavney, B.D., Kathiresan, S., Kähönen, M., Jula, A., Jukema, J.W., Jousilahti, P., Joshi, P.K., Johnson, A.D., Johansson, Å., Joehanes, R., Jarvelin, M.-R., Jansen, R., James, A., Ingelsson, E., Hwang, S.-J., Huffman, J.E., Hottenga, J.-J., Hofman, A., Hofer, E., Hicks, A.A., Havulinna, A.S., Hartman, C.A., Harris, S.E., Harris, T.B., Hamsten, A., Gyllensten, U., Guo, X., Gudnason, V., Gow, A.J., Goel, A., Girotto, G., Gieger, C., Giedraitis, V., Gasparini, P., Gandin, I., Franco, O.H., Frånberg, M., Ferreira, T., Erzurumluoglu, A.M., Enroth, S., Elosua, R., Ehret, G.B., Dörr, M., Demirkale, C.Y., Del Greco M, F., Deelen, J., Deary, I.J., de Geus, E.J., de Borst, M.H., Davies, G., Cordell, H.J., Collins, F., Cocca, M., Ciullo, M., Chauhan, G., Chambers, J.C., Chakravarti, A., Campbell, H., Campbell, A., Brumat, M., Braund, P.S., Bottinger, E.P., Boomsma, D.I., Boerwinkle, E., Boehnke, M., Bochud, M., Blake, T., Bis, J.C., Batini, C., Barbieri, C.M., Ayers, K.L., Arking, D.E., Amin, N., Abecasis, G., Thom, S., Stanton, A., Shields, D.C., Poulter, N.R., Paré, G., Noordam, R., Morris, A.D., Menni, C., Farrall, M., Doney, A.S.F., de Mutsert, R., Connell, J., Amouyel, P., Zhao, J.-H., Willems, S.M., Verweij, N., Thériault, S., Surendran, P., Shah, N., Sargurupremraj, M., Qian, Y., Prins, B.P., Oldmeadow, C., Mangino, M., Luan, J., Lin, W.-Y., Li-Gao, R., Jackson, A.U., Holliday, E.G., Giulianini, F., Ding, J., Debette, S., Boutin, T., Almgren, P., Milani, L., Mägi, R., Esko, T., Kovesdy, C.P., Tsao, P.S., Wilson, P.W.F., Gaziano, J.M., Cho, K., Sun, Y.V., Velez Edwards, D.R., Giri, A., Hellwege, J.N., Tzanis, E., Witkowska, K., Evangelou, M., Ng, F.L., Karaman, I., Cabrera, C.P., Dimou, N., Ntritsos, G., Gao, H., Pazoki, R., Mifsud, B., Mosen-Ansorena, D., Warren, H.R., Evangelou, E., Nature Genetics, 2018, 10.1038/s41588-018-0297-3

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals, Howson, J.M.M., Munroe, P.B., Newton-Cheh, C., Levy, D., Chasman, D.I., Boerwinkle, E., Stefansson, K., Saleheen, D., Psaty, B.M., O’Donnell, C.J., Morrison, A.C., Morris, A.P., Manning, A.K., Liu, C., Lindgren, C.M., Holm, H., Edwards, T.L., Danesh, J., Caulfield, M.J., Butterworth, A.S., Tomaszewski, M., Langenberg, C., O’Donnell, C.J., Hung, A.M., Edwards, T.L., Wilson, P.W.F., Tsao, P.S., Sun, Y.V., Kovesdy, C.P., Gaziano, J.M., Cho, K., Edwards, D.R.V., Giri, A., Hellwege, J.N., Charchar, F.J., Zeggini, E., Weir, D.R., Völker, U., Virtamo, J., Verweij, N., Ramachandran, V.S., van der Meer, P., van der Harst, P., Zeggini, E., Prins, B.P., Tobin, M.D., Timpson, N.J., Lakka, T.A., Taylor, K.D., Sebert, S., Starr, J.M., Spector, T.D., Soranzo, N., Smith, B.H., Sheu, W.H.-H., Sattar, N., Samani, N.J., Salomaa, V., Rudan, I., Rotter, J.I., Rosendaal, F.R., Rolandsson, O., Ridker, P.M., Rice, K., Relton, C.L., Province, M.A., Prentice, A.M., Porteous, D.J., Polasek, O., Palmas, W., Padmanabhan, S., Packard, C.J., Orho-Melander, M., Nordestgaard, B.G., Murray, A.D., Mohlke, K.L., Melander, O., McCarthy, M.I., Laakso, M., Majumder, A.S., Loos, R.J.F., Lind, L., Launer, L.J., Kooperberg, C., Kooner, J.S., Kee, F., Kardia, S.L.R., Jukema, J.W., Järvelin, M.-R., Tuomilehto, J., Ingelsson, E., Herzig, K.-H., Hennig, B.J., Hayward, C., Harris, T.B., Gudnason, V., Groop, L., Gaunt, T.R., Gambaro, G., Frossard, P., Franks, S., Franks, P.W., Fornage, M., Ford, I., Ferrières, J., Felix, S.B., Wareham, N.J., Rolandsson, O., Franks, P.W., McCarthy, M.I., Langenberg, C., Danesh, J., Butterworth, A.S., Elliott, P., Di Angelantonio, E., Deloukas, P., Dedoussis, G., Deary, I.J., Boer, R.A., Davey Smith, G., Correa, A., Conen, D., Chowdhury, R., Chen, Y.-D.I., Chambers, J.C., Buring, J.E., Bottinger, E.P., Bots, M.L., Boehnke, M., Blakemore, A.I., Barnes, M.R., Asselbergs, F.W., Amouyel, P., Almgren, P., Aliya, N., Zhang, H., Yonova-Doing, E., Witte, D.R., Willer, C.J., Wilson, P.W.F., Vergnaud, A.-C., Vaartjes, I., Tzoulaki, I., Turner, S.T., Tuomi, T., Tsao, P.S., Trabetti, E., Esko, T., Thorgeirsson, G., Sundstrom, J., Sun, Y.V., Skaaby, T., Sigurdsson, E.L., Sever, P.S., Schreiner, P.J., Rossouw, J., Rettig, R., Renström, F., Mägi, R., Rayner, N.W., Rasmussen, K.L., Rasheed, A., Poulter, N., Peters, J., Pedersen, O., Papanicolaou, G.J., Palmer, C.N.A., Neville, M.J., Nadkarni, G., Moitry, M., Martin, L.W., Linneberg, A., Verweij, N., van der Meer, P., van der Harst, P., de Boer, R.A., Lee, W.-J., Lee, I.-T., Lannfelt, L., Laatikainen, T., Kuulasmaa, K., Kovesdy, C.P., Koistinen, H.A., Karpe, F., Käräjämäki, A.M., Kamat, M., Kajantie, E., Jousilahti, P., Jørgensen, M.E., Heiss, G., Have, C.T., Hansen, T., Hallmans, G., Grove, M.L., Grarup, N., Gaziano, J.M., Farmaki, A.-E., Eiriksdottir, G., Dörr, M., Dominiczak, A.F., Mutsert, R., Connell, J., Christensen, C., Cho, K., Burgess, S., Braund, P.S., Brandslund, I., Bork-Jensen, J., Bonnycastle, L.L., Blankenberg, S., Asllanaj, E., Aeschbacher, S., Evangelou, E., Zhao, W., Zhao, W., Zhao, J.-H., Zhang, W., Yu, B., Young, R., Yao, J., Willems, S.M., Weiss, S., Veronesi, G., Velez Edwards, D.R., Varga, T.V., Trompet, S., Thorsteinsdottir, U., Thériault, S., Sulem, P., Stanáková, A., Staley, J.R., Smith, J.A., Smith, A.V., Sim, X., Sepúlveda, N., Richardson, T.G., Richard, M., Rauramaa, R., Poveda, A., Perola, M., Paul, D.S., Paré, G., Müller-Nurasyid, M., Mosen-Ansorena, D., Mook-Kanamori, D.O., Menni, C., Mei, H., Masca, N.G.D., Malerba, G., Mahajan, A., Luan, J., Lu, Y., Lotta, L.A., Lindström, J., Larson, M.G., Li-Gao, R., Kontto, J., Kanoni, S., Hwang, S.-J., Huffman, J.E., Helgadottir, A., Havulinna, A.S., Harris, S.E., Guo, X., Gudbjartsson, D.F., Giulianini, F., Giannakopoulou, O., Gao, H., Franceschini, N., Foley, C.N., Ferreira, T., Fava, C., Fauman, E.B., Faul, J.D., Nielsen, S.F., Drenos, F., Warren, H.R., Daw, E.W., Brody, J.A., Braithwaite, V.S., Bis, J.C., Bielak, L.F., Auer, P.L., Akbarov, A., Eales, J.M., Cabrera, C.P., Stewart, I.D., Prins, B.P., Liu, D.J., Thorleifsson, G., Tragante, V., Giri, A., Hellwege, J.N., Cartwright, J.H., Kraja, A.T., Yao, C., Mifsud, B., Chen, L., Cook, J., Karthikeyan, S., Ntalla, I., Lahrouchi, N., Feofanova, E.V., Surendran, P., Nature Genetics, 2020, 10.1038/s41588-020-00713-x

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction, Munroe, P.B., Lubitz, S.A., Jamshidi, Y., Ellinor, P.T., Stefansson, K., Tinker, A., Benjamin, E.J., Thorsteinsdottir, U., Thorolfsdottir, R.B., Thorleifsson, G., Sulem, P., Holm, H., Gudbjartsson, D.F., Arnar, D.O., van Duijvenboden, S., Ramirez, J., Orini, M., Lambiase, P.D., Yldau van der Ende, M., Abdullah Said, M., Assa, S., Stilp, A., Seyerle, A.A., Laurie, C.C., Kerr, K.F., Gogarten, S.M., Avery, C.L., Soliman, E.Z., Ehret, G.B., Boerwinkle, E., Arking, D.E., Alonso, A., Whitsel, E.A., Reiner, A.P., Peters, U., Kooperberg, C., Jackson, R.D., Haessler, J., van den Berg, M.E., Uitterlinden, A., Stricker, B.H., Smith, B.H., Porteous, D.J., Murray, A.D., Lunetta, K.L., Newton-Cheh, C.H., Lin, H., Levy, D., Tarasov, K.V., Qian, Y., Lakatta, E.G., Ding, J., Cucca, F., Noordam, R., Mook-Kanamori, D.O., Maan, A.C., de Mutsert, R., Yao, J., Taylor, K.D., Rotter, J.I., Lin, H.J., Heckbert, S.R., Guo, X., Salomaa, V., Jula, A., Sääksjärvi, K., Havulinna, A.S., Weiss, S., Völker, U., Felix, S.B., Dörr, M., Trompet, S., Macfarlane, P.W., Wouter Jukema, J., Ford, I., Pramstaller, P.P., Pattaro, C., Fuchsberger, C., de Grandi, A., Sotoodehnia, N., Rice, K., Psaty, B.M., Brody, J.A., Bis, J.C., Biggs, M.L., Gustav Smith, J., Benjamin Shoemaker, M., Roden, D.M., Olesen, M., London, B., Fatkin, D., Cutler, M.J., Strauch, K., Sinner, M.F., Schramm, K., Kääb, S., Verweij, N., van der Harst, P., van de Vegte, Y.J., Rienstra, M., Spector, T.D., Mangino, M., Waldenberger, M., Müller-Nurasyid, M., Peters, A., Meitinger, T., Wilson, J., Mei, H., Correa, A., Preuss, M.H., Nadkarni, G.N., Loos, R.J.F., Bottinger, E.P., Smith, A.V., Launer, L.J., Harris, T.B., Gudnason, V., Huang, P.L., van Duijn, C.M., Kors, J.A., Isaacs, A., Wilson, J.F., Joshi, P.K., Campbell, H., Barnes, C.L.K., Raitakari, O.T., Lyytikäinen, L.-P., Lehtimäki, T., Hutri-Kähönen, N., Thériault, S., Risch, L., Conen, D., Aeschbacher, S., Shuldiner, A.R., Ryan, K., O'Connell, J.R., Montasser, M.E., Padmanabhan, S., Dominiczak, A., Caulfield, M.J., Nikus, K., Mononen, N., Mishra, P.P., Kähönen, M., Ulivi, S., Sinagra, G., Samani, N.J., Riaz, M.B., Nelson, C.P., Sundström, J., Lindgren, C.M., Lind, L., Cook, J.P., Hicks, A.A., Gögele, M., Foco, L., Fabiola Del Greco, M., Morris, A.P., Mahajan, A., Ingelsson, E., Giedraitis, V., Tarazona-Santos, E., Souza, R.P., Ribeiro, A.L.P., Lima-Costa, M.F., Araujo, N.M., Rudan, I., Polasek, O., Kolcic, I., Boutin, T., Gasparini, P., Concas, M.P., Cranley, J.J., Marten, J., Hayward, C., Warren, H.R., Mifsud, B., Barnes, M.R., Roselli, C., Chaffin, M.D., Choi, S.H., Tucker, N.R., Sveinbjornsson, G., Hall, A.W., Cartwright, J.H., Weng, L.-C., Ntalla, I., bioRxiv, 2019, 10.1101/712398

Mendelian Randomization of Circulating Proteome Identifies Actionable Targets in Heart Failure, Mathieu, P., Arsenault, B., Thériault, S., Bossé, Y., Mathieu, S., Moncla, L.-H.M., ResearchSquare, 2022, 10.21203/rs.3.rs-1547537

A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization, Arsenault, B.J., Mathieu, P., Koschinsky, M.L., Thériault, S., Boffa, M.B., Pibarot, P., Droit, A., Couture, P., Després, A.-A., Scipione, C.A., Capoulade, R., Mass, E., Poggio, P., Bourassa, S., Couture, C., Gotti, C., Mitchell, P.L., Guertin, J., Perrot, N., Girard, A., Bourgeois, R., CJC Open, 2021, 10.1016/j.cjco.2020.11.019

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets from Blood and the Kidney, Ehret, G.B., Caulfield, M.J., Snieder, H., Tobin, M.D., Levy, D., Morris, A.P., Knight, J., Chakravarti, A., Chasman, D.I., Elliott, P., Munroe, P.B., Newton-Cheh, C., Bochud, M., Franco, O.H., Boomsma, D.I., Ingelsson, E., Metspalu, A., Palmas, W., Strachan, D.P., Jukema, J.W., James, A., Rettig, R., Peters, A., Psaty, B.M., Gudnason, V., Van Duijn, C.M., Lehtimäki, T., Zhao, J.H., Schmidt, H., Wilson, J.F., Perola, M., Toniolo, D., Salomaa, V., Hartman, C.A., Watkins, H., Liu, Y., Laan, M., Gasparini, P., Scott, R.A., Hicks, A.A., Keavney, B.D., Elosua, R., Ciullo, M., Deary, I.J., Knekt, P., Gyllensten, U., Tuomilehto, J., Samani, N.J., Vitart, V., Lindgren, C.M., Kooner, J.S., Hayward, C., Girotto, G., Starr, J.M., Polasek, O., Loos, R.J.F., Vergnaud, A.-C., Palmer, C.N.A., Van Der Harst, P., Spector, T.D., Zeggini, E., Mook-Kanamori, D.O., Debette, S., Sever, P., Attia, J., Conen, D., Thériault, S., Yao, J., Wright, A.F., Willemsen, G., Wild, S., Vollenweider, P., Völker, U., Uitterlinden, A.G., Tzourio, C., Tzoulaki, I., Thom, S., Taylor, K.D., Swertz, M., Sundström, J., Stott, D.J., Stanton, A., Sorice, R., Siscovick, D., Shields, D.C., Seelen, M.A., Scott, R., Schmidt, R., Sarin, A.-P., Sala, C.F., Saint Pierre, A., Saba, Y., Rudan, I., Rotter, J.I., Robino, A., Ripatti, S., Riese, H., Ridker, P.M., Rice, K., Ren, M., Raitakari, O.T., Pramstaller, P.P., Poulter, N., Penninx, B.W.J.H., Pattie, A., Paré, G., Palotie, A., Padmanabhan, S., Org, E., Oostra, B.A., Oldehinkel, A.J., Nutile, T., Nguyen, Q.T., Nandakumar, P., Munson, P.J., Morrison, A.C., Morris, A.D., Morgan, A., Milaneschi, Y., Mifsud, B., Menni, C., Mamasoula, C., Mach, F., Lind, L., Lin, L., Liewald, D.C.M., Lehne, B., Launer, L.J., Larson, M., Langenberg, C., Koskinen, S., Kolcic, I., Khaw, K.-T., Kathiresan, S., Kähönen, M., Jula, A., Jousilahti, P., Johnson, A.D., Johansson, Å., Jarvelin, M.-R., Hui, J., Holliday, E.G., Hofman, A., Harris, T.B., Hamsten, A., Gow, A.J., Giulianini, F., Gieger, C., Giedraitis, V., Gao, H., Frånberg, M., Ferreira, T., Farrall, M., Dörr, M., Doney, A.S.F., Demirkale, Y., Deelen, J., De Mutsert, R., De Geus, E.J., Davies, G., Damman, J.J., Cordell, H.J., Connell, J., Collins, F., Cocca, M., Chambers, J.C., Campbell, H., Brumat, M., Brown, M., Braund, P.S., Bottinger, E.P., Boehnke, M., Blake, T., Beilby, J., Batini, C., Barnes, M.R., Barbieri, C.M., Abedi, M., Abecasis, G., Oldmeadow, C., Chauhan, G., Li-Gao, R., Campbell, A., Prins, B.P., Mangino, M., De Borst, M.H., Shah, N., Evangelou, E., Lu, Y., Zemunik, T., Harris, S.E., Gandin, I., Marten, J., Zhang, W., Huffman, J.E., Nelson, C.P., Jackson, A.U., Enroth, S., Niiranen, T., Lopez, L.M., Ruggiero, D., Marrugat, J., Ayers, K.L., Del Greco, F.M., Luan, J., Vuckovic, D., Sõber, S., Nalls, M.A., Goel, A., Havulinna, A.S., Traglia, M., Kristiansson, K., Joshi, P.K., Hofer, E., Wareham, N.J., Mahajan, A., Lyytikäinen, L.-P., Nolte, I.M., Amin, N., Smith, A.V., Bis, J.C., Ried, J.S., Teumer, A., Shrine, N., Trompet, S., Kutalik, Z., Guo, X., Hwang, S.-J., Arking, D.E., Esko, T., Strawbridge, R.J., Hottenga, J.-J., Verwoert, G.C., Rose, L.M., Warren, H.R., Cabrera, C.P., O'Reilly, P.F., Erzurumluoglu, A.M., Van Der Most, P.J., Joehanes, R., Jansen, R., Vaez, A., Wain, L.V., Hypertension, 2017, 10.1161/HYPERTENSIONAHA.117.09438

Mendelian Randomization Analysis Identifies Blood Tyrosine Levels as a Biomarker of Non-Alcoholic Fatty Liver Disease, Benoit Arsenault, André Tchernof, Tõnu Esko, Sébastien Thériault, Marie-Claude Vohl, Jacques Corbeil, François Julien, Patrick Mathieu, Patricia Mitchell, Christian Couture, Hasanga Dilshan Manikpurage, Eloi Gagnon, Jérôme Bourgault, Erik Abner, Nooshin Ghodsian, Francis Brière, Nele Taba, Ina Maltais-Payette, Émilie Gobeil, Metabolites, 2022, 10.3390/metabo12050440

Integrative Analysis of the Blood Proteome by Mendelian Randomization Reveals Regulatory Networks in Calcific Aortic Valve Disease, Patrick Mathieu, Yohan Bossé, Benoit Arsenault, Sébastien Thériault, Anne Rufiange, Samuel Mathieu, Valentine Duclos, Louis-Hippolyte Minvielle Moncla, Mewen Briend, 2023, 10.1101/2023.07.26.23293222

A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases, Arsenault, B.J., Mathieu, P., Thériault, S., Bossé, Y., Ghodsian, N., Mitchell, P.L., Li, Z., Couture, C., Bourgault, J., Pelletier, W., Perrot, N., Aging Cell, 2021, 10.1111/acel.13497

Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men, Sébastien Thériault, Benoit J. Arsenault, Yohan Bossé, Patrick Mathieu, Christian Couture, Zhonglin Li, Nicolas Perrot, Aida Eslami, Hasanga D. Manikpurage, Circulation: Genomic and Precision Medicine, 2021, 10.1161/CIRCGEN.121.003452

A multidimensional Mendelian randomization study on the impact of gut dysbiosis on chronic diseases and human longevity, Benoit J. Arsenault, Patrick Mathieu, Sébastien Thériault, Nooshin Ghodsian, Tõnu Esko, Nele Taba, Erik Abner, Hasanga Manikpurage, Patricia L. Mitchell, Éloi Gagnon, 2021, 10.1101/2021.08.20.21262026

Genetic association analyses highlight IL6, ALPL, and NAV1 as three new susceptibility genes underlying calcific aortic valve stenosis, Schott, J.-J., Bossé, Y., Le Tourneau, T., Mathieu, P., Pibarot, P., Dagenais, F., Redon, R., Roussel, R., Probst, V., Baufreton, C., Verhoye, J.P., Roussel, J.-C., Fellah, I., Charpentier, E., Karakachoff, M., Bonnaud, S., Baron, E., Lecointe, S., Boureau, A.-S., Arsenault, B.J., Clavel, M.-A., Lamontagne, M., Simonet, F., Rigade, S., Li, Z., Gaudreault, N., Capoulade, R., Le Scouarnec, S., Messika-Zeitoun, D., Dina, C., Thériault, S., bioRxiv, 2019, 10.1101/515494

Granularity of SERPINA1 alleles by DNA sequencing in CanCOLD, Bossé, Y., Bourbeau, J., Tan, W., Maltais, F., Kirby, M., Henry, C., Li, P.Z., Thériault, S., Gaudreault, N., Gupta, N., European Respiratory Journal, 2020, 10.1183/13993003.00958-2020

Genetic Susceptibility for Atrial Fibrillation in Patients Undergoing Atrial Fibrillation Ablation, Lubitz, S., Roden, D.M., Bollmann, A., Rienstra, M., Conen, D., Sinner, M.F., Cutler, M.J., Nazarian, S., Chung, M., Natale, A., Ellinor, P., Kaä¨b, S., Michaud, G., Darbar, D., Calkins, H., Barnard, J., Hindricks, G., Van Gelder, I.C., Jacobs, V., Weeke, P., Issa, T., Wells, Q., Yoneda, Z., Montgomery, J., Müller-Nurasyid, M., Freudling, R., Van Wagoner, D.R., Smith, J.D., Blum, S., Aeschbacher, S., Geelhoed, B., Büttner, P., Zardkoohi, O., Ueberham, L., Crawford, D.M., Siland, J.E., Rinke, L.L., Thériault, S., Shaffer, C., Mohanty, S., Sun, H., Knight, S., Neumann, B., Kühne, M., Chrispin, J., Al Jazairi, M., Roselli, C., Husser, D., Shoemaker, M.B., Circulation: Arrhythmia and Electrophysiology, 2020, 10.1161/CIRCEP.119.007676

Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases, Mathieu, P., Arsenault, B.J., Thériault, S., Bossé, Y., Argaud, D., Li, Z., Boulanger, M.-C., Bon-Baret, V., Chignon, A., Communications Biology, 2020, 10.1038/s42003-020-0937-x

Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk A Mendelian Randomization Analysis, Boekholdt, S.M., Thériault, S., Mathieu, P., Stroes, E.S.G., Pibarot, P., Bossé, Y., Wareham, N.J., Khaw, K.-T., Couture, C., Perrot, N., Kaiser, Y., Pelletier, W., Arsenault, B.J., JAMA Network Open, 2020, 10.1001/jamanetworkopen.2020.0129

Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans, Arsenault, B.J., Thanassoulis, G., Bosse, Y., Mathieu, P., Schott, J.J., Smith, J.G., Pibarot, P., Clavel, M.-A., Wareham, N.J., Engert, J.C., Messika-Zeitoun, D., Le Tourneau, T., Capoulade, R., Boekholdt, S.M., Martinsson, A., Dina, C., Chen, H.Y., Rigade, S., Theriault, S., Perrot, N., Heart, 2020, 10.1136/heartjnl-2020-316722

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk, Morris, A.P., Bochud, M., Franco, O.H., Boomsma, D.I., Ingelsson, E., Palmas, W., Strachan, D.P., Wouter Jukema, J., James, A., Rettig, R., Peters, A., Psaty, B.M., Gudnason, V., van Duijn, C.M., Lehtimäki, T., Zhao, J.H., Schmidt, H., Wilson, J.F., Perola, M., Toniolo, D., Salomaa, V., Hartman, C.A., Watkins, H., Liu, Y.M., Laan, M., Gasparini, P., Scott, R.A., Hicks, A.A., Elosua, R., Ciullo, M., Deary, I.J., Knekt, P., Gyllensten, U., Tuomilehto, J., Vitart, V., Girotto, G., Starr, J.M., Polasek, O., Loos, R.J.F., Vergnaud, A.-C., Palmer, C.N.A., Spector, T.D., Zeggini, E., Mook-Kanamori, D.O., Debette, S., John, A., Conen, D., Thériault, S., Yao, J., Wright, A.F., Willemsen, G., Wild, S., Vollenweider, P., Völker, U., Uitterlinden, A.G., Tzourio, C., Taylor, K.D., Swertz, M., Sundström, J., Stott, D.J., Sorice, R., Siscovick, D., Seelen, M.A., Scott, R., Schmidt, R., Sarin, A.-P., Sala, C.F., Saint Pierre, A., Saba, Y., Rudan, I., Rotter, J.I., Robino, A., Ripatti, S., Riese, H., Ridker, P.M., Rice, K., Raitakari, O.T., Pramstaller, P.P., Penninx, B.W.J.H., Pattie, A., Paré, G., Org, E., Palotie, A., Oostra, B.A., Oldehinkel, A.J., Nutile, T., Nguyen, Q.T., Nandakumar, P., Munson, P.J., Morrison, A.C., Morris, A.D., Morgan, A., Milaneschi, Y., Menni, C., Mamasoula, C., Mach, F., Lind, L., Lin, L., Liewald, D.C.M., Lehne, B., Launer, L.J., Larson, M., Langenberg, C., Koskinen, S., Kolcic, I., Khaw, K.-T., Kathiresan, S., Jula, A., Kähönen, M., Jousilahti, P., Johnson, A.D., Johansson, Å., Jarvelin, M.-R., Holliday, E.G., Hofman, A., Harris, T.B., Hamsten, A., Gow, A.J., Giulianini, F., Gieger, C., Giedraitis, V., Frånberg, M., Ferreira, T., Dörr, M., Doney, A.S.F., Demirkale, Y., Deelen, J., de Mutsert, R., de Geus, E.J., Davies, G., Damman, J.J., Cordell, H.J., Collins, F., Cocca, M., Campbell, H., Brumat, M., Braund, P.S., Bottinger, E.P., Boehnke, M., Blake, T., Batini, C., Barbieri, C.M., Abedi, M., Abecasis, G., Oldmeadow, C., Chauhan, G., Li-Gao, R., Campbell, A., Prins, B.P., Mangino, M., de Borst, M.H., Shah, N., Lu, Y., Zemonik, T., Harris, S.E., Gandin, I., Zhang, W., Huffman, J.E., Nelson, C.P., Jackson, A.U., Enroth, S., Niiranen, T., Lopez, L.M., Ruggiero, D., Marrugat, J., Ayers, K.L., Fabiola Del Greco, M., Luan, J., Vuckovic, D., Sõber, S., Nalls, M.A., Goel, A., Havulinna, A.S., Traglia, M., Kristiansson, K., Joshi, P.K., Hofer, E., Wareham, N.J., Mahajan, A., Lyytikäinen, L.-P., Amin, N., Nolte, I.M., Smith, A.V., Bis, J.C., Ried, J.S., Teumer, A., Shrine, N., Trompet, S., Kutalik, Z., Guo, X., Hwang, S.-J., Arking, D.E., Esko, T., Strawbridge, R.J., Hottenga, J.-J., Verwoert, G.C., Rose, L.M., O'Reilly, P., Mesut Erzurumluoglu, A., van der Most, P.J., Joehanes, R., Jansen, R., Vaez, A., Wain, V., Elliott, P., Caulfield, M.J., Tzoulaki, I., Barnes, M.R., Wain, L.V., Ehret, G.B., Munroe, P.B., Tobin, M.D., Howson, J.M.M., Samani, N.J., Tomaszewski, M., Keavney, B., Kooner, J.S., Levy, D., Lindgren, C.M., Newton-Cheh, C., Chakravarti, A., Chasman, D.I., Chambers, J.C., Chowdhury, R., Saleheen, D., van der Harst, P., Hayward, C., Esko, T., Sever, P., Brown, M., Thom, S., Shields, D.C., Metspalu, A., Bakker, S.J.L., Connell, J., Stanton, A., Mägi, R., Padmanabhan, S., Gansevoort, R.T., Farrall, M., Poulter, N., Alver, M., Porteous, D., Abdullah Said, M., Shyong Tai, E., He, J., Kato, N., Snieder, H., Knight, J., O'Reilly, P.F., Segura Lepe, M.P., Karaman, I., Marten, J., Verweij, N., Loh, M., Drenos, F., Kraja, A.T., Cook, J.P., Liu, C., Surendran, P., Ntalla, I., Mifsud, B., Ren, M., Gao, H., Cabrera, C.P., Evangelou, E., Warren, H.R., Nature Genetics, 2017, 10.1038/ng.3768

Long-Term Exposure to Elevated Lipoprotein(a) Levels, Parental Lifespan and Risk of Mortality, Boekholdt, S.M., Thériault, S., Mathieu, P., Stroes, E.S.G., Pibarot, P., Bossé, Y., Wareham, N.J., Khaw, K.-T., Couture, C., Perrot, N., Kaiser, Y., Pelletier, W., Arsenault, B.J., bioRxiv, 2019, 10.1101/615898

HDL Cholesterol, LDL Cholesterol, and Triglycerides as Risk Factors for CKD: A Mendelian Randomization Study, Paré, G., Walsh, M., Thériault, S., Lanktree, M.B., American Journal of Kidney Diseases, 2018, 10.1053/j.ajkd.2017.06.011

Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease, Mathieu, P., Thériault, S., Arsenault, B.J., Bossé, Y., Voisine, P., Argaud, D., Rufiange, A., Mathieu, S., Chignon, A., Human Genomics, 2022, 10.1186/s40246-022-00381-4

Polygenic risk score predicts prevalence of cardiovascular disease in patients with familial hypercholesterolemia, Baass, A., Paré, G., Dufour, R., Thériault, S., Chong, M., Paquette, M., Journal of Clinical Lipidology, 2017, 10.1016/j.jacl.2017.03.019

Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms, Mathieu, P., Arsenault, B.J., Esko, T., Thériault, S., Bossé, Y., Li, Z., Couture, C., Abner, E., Briend, M., Mathieu, S., iScience, 2022, 10.1016/j.isci.2022.104992

Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis, Sébastien Thériault, Yohan Bossé, Patrick Mathieu, Benoit J. Arsenault, Nathalie Gaudreault, Zhonglin Li, Communications Biology, 2020, 10.1038/s42003-020-01210-x

Atrial fibrillation genetic risk differentiates cardioembolic stroke from other strokel subtypes, Sheth, K., Lee, J.-M., Heitsch, L., Bushnell, C., Langefeld, C., Fernandez-Cadenas, I., Montaner, J., Spence, D., Longstreth, W., Tirschwell, D., Bennett, S., Keene, K., Cushman, M., Majersik, J., Fornage, M., Giese, A.-K., Farrall, M., Attia, J., Maguire, J., Kalaria, R., Holliday, E., Brown, D., Brown, R., Chang, Y.-C., Dobbins, M., Chang, C., Nakagawa, K., Pedersen, A., Walters, M., McDonough, C., Silliman, S., Rannikmae, K., Sudlow, C., Doney, A., Kissela, B., Broderick, J., Saleheen, D., Fisher, M., Cramer, S., Padovani, A., Pezzini, A., Arnett, D., Perry, R., Macleod, M., Algra, A., van't Hof, F., Klijn, K., Thijs, V., Martin, J.J., Smith, G., Norrving, B., Hansen, B., Lindgren, A., Smalley, J., Sofat, R., Werring, D., Karaszewski, B., Stine, C., Illoh, K., Milewicz, D., O'Connell, J., Cole, J., Woo, D., Howard, G., Lam, O., Jain, V., Taqi, M., Giraldo, E., Chern, J., Chiou, H.Y., Sheu, W., Bevan, S., Peycke, J., Markus, H., Kilarski, L., Lee, C., Kim, H., Olsson, S., Jood, K., Jern, C., Mok, V., Lebedeva, E., Schilling, S., Rothwell, P., Olugbodi, A., Tan, E.K., Lee, W.L., Le, K.E., Chen, C., Waddy, S., Singleton, A., Corriveau, R., Gwinn, K., Barr, T., Deng, Z., Gschwendtner, A., Chan, Y.-F.Y., Sacco, R., Rundek, T., Bersano, A., Yamada, Y., Blanton, S., Seiler, S., Schmidt, R., Schmidt, H., Enzinger, C., Pichler, A., Brott, T., Meschia, J., Mueller-Myhsok, B., Battey, T., Kourkoulis, C., Du, R., Brouwers, B., Falcone, G., Anderson, C., Biffi, A., Romero, J., Sadr-Nabavi, A., Burri, P., Staals, J., Gonik, M., Duering, M., Opherk, C., Ahmadi, K., Lemmens, R., Kostulas, K., Crisby, M., Keller, L., Goncalves, A., Franca, P., Cabral, N., Cendes, I., Nyquist, P., Levi, C., Juchniewicz, K.J., Slowik, A., Pera, J., Olszanecki, R., Wnuk, M., Gasowski, J., Jagiella, J., Dziedzic, T., Urbanik, A., Mateusz, A., Parati, E., Ballabio, E., Boncoraglio, G., Korostynski, M., Hardy, J., Cotlarcius, I., Jimenez-Conde, J., Roquer, J., Giralt, E., Soriano, C., Bijlenga, P., Happola, O., Tatlisumak, T., Rich, S., Sharma, P., Olesen, J., Kidwell, C., Carty, C., Leys, D., O'Donnell, C., Breteler, M., James, M.L., Goldstein, L., Elkind, M., Chang, K.-C., Lee, T.-H., Luke, M., Sale, M., Chen, I., Rexrode, K., Seshadri, S., Wolf, P., Pikula, A., Selim, M., Wang, X., Sorkin, J., Smoller, S., Lunetta, K.L., Tanaka, T., Heckbert, S.R., Chasman, D.I., Kääb, S., Roden, D.M., Alonso, A., Gudnason, V., Felix, S.B., Chung, M.K., Stricker, B.H., Lehtimäki, T., März, W., Rotter, J.I., Hayward, C., Wouter Jukema, J., Pereira, A., Kathiresan, S., Lokki, M.-L., van der Harst, P., Conen, D., Laurikka, J., Loos, R.J.F., Melander, O., Kooperberg, C., Ingelsson, E., Dichgans, M., Guo, X., Lin, H.J., Sinner, M.F., Jöckel, K.-H., Völker, U., Franco, O.H., Hofman, A., Uitterlinden, A.G., Soliman, E.Z., Sotoodehnia, N., Huang, P.L., Almgren, P., Heilmann, S., Macfarlane, P.W., Shaffer, C., Newton-Cheh, C., Darbar, D., Kriebel, J., Denny, J.C., Heeringa, J., Hamsten, A., Orho-Melander, M., Nikus, K., Pedersen, N.L., Vlachopoulou, E., Hocking, L.J., Porteous, D., Magnusson, P.K., Campbell, A., Taylor, K.D., Rost, N., Lannfelt, L., Eisele, L., Boerwinkle, E., Li, M., Sandhu, R.K., Chen, Y.-D.I., Chen, L.Y., Delgado, G., Reiner, A.P., Ford, I., Morris, A.P., Eskola, M., Huang, J., Wong, J.A., Lindgren, C.M., Hernesniemi, J., Bottinger, E.B., Lu, Y., Scott, S.A., Lind, L., Smith, B.H., Peters, A., Mansur, A.J., Risch, L., Kähönen, M., Krieger, J.E., Arendt, M., Lichtner, P., Waldenberger, M., Bartz, T.M., Haessler, J., Padmanabhan, S., Benjamin Shoemaker, M., Launer, L.J., Harris, T.B., Magnani, J.W., Ridker, P.M., Psaty, B.M., Perz, S., Bis, J.C., Van Wagoner, D.R., Smith, J.D., Kubo, M., Siland, J.E., Verweij, N., Hagemeijer, Y.P., Kamatani, Y., Paré, G., Worrall, B.B., Yang, Q., Chauhan, G., Debette, S., Hopewell, J.C., Sun, A., Shah, S., Rader, D.J., Deo, R., Clauss, S., Teumer, A., Weiss, S., Radmanesh, F., Yao, J., Thériault, S., Aeschbacher, S., Sinisalo, J., Perez, M., Horimoto, A.R.V.R., Malik, R., Seppälä, I., Lyytikäinen, L.-P., Kleber, M.E., Schurmann, C., Gustafsson, S., Huffman, J., Trompet, S., Dörr, M., Niemeijer, M.N., Brody, J.A., Gustav Smith, J., Müller-Nurasyid, M., Weeke, P.E., Low, S.-K., Bihlmeyer, N.A., Klarin, D., Li, M., Tucker, N.R., Chaffin, M., Albert, C.M., Smith, A.V., Arking, D.E., Lin, H., Barnard, J., Geelhoed, B., Yin, X., Roselli, C., Rienstra, M., Christophersen, I.E., Anderson, C.D., Lubitz, S.A., Kittner, S.J., Ellinor, P.T., Benjamin, E.J., de Bakker, P.I.W., Rosand, J., Mitchell, B.D., Choi, S.H., Trinquait, L., McArdle, P.F., Weng, L.-C., Pulit, S.L., bioRxiv, 2017, 10.1101/239269

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits, Caulfield, M.J., Elliott, P., Wain, L.V., Barnes, M.R., Tzoulaki, I., Psaty, B.M., Edwards, T.L., O’Donnell, C.J., Hung, A.M., Metspalu, A., Brown, M.J., Newton-Cheh, C., Munroe, P.B., Levy, D., Zeggini, E., Wareham, N.J., van der Harst, P., Spector, T.D., Sever, P., Scott, R.J., Scott, R.A., Risch, L., Palmer, C.N.A., Mook-Kanamori, D.O., Melander, O., Langenberg, C., Lakatta, E.G., Laakso, M., Howson, J.M.M., Hayward, C., Danesh, J., Cucca, F., Conen, D., Chasman, D.I., Butterworth, A.S., Attia, J.R., Zhang, W., Zemunik, T., Yao, J., Wright, A.F., Wilson, J.F., Willemsen, G., Wild, S.H., Watkins, H., Vuckovic, D., Vollenweider, P., Völker, U., Vitart, V., Verwoert, G.C., Vergnaud, A.-C., van Duijn, C.M., van der Most, P.J., Vaez, A., Uitterlinden, A.G., Tzourio, C., Tuomilehto, J., Trompet, S., Traglia, M., Toniolo, D., Tomaszewski, M., Tobin, M.D., Teumer, A., Taylor, K.D., Swertz, M.A., Sundström, J., Strawbridge, R.J., Strachan, D.P., Stott, D.J., Starr, J.M., Sorice, R., Sõber, S., Snieder, H., Smith, A.V., Siscovick, D., Shrine, N., Schmidt, H., Schmidt, R., Sarin, A.-P., Samani, N.J., Salomaa, V., Sala, C.F., Saba, Y., Ruggiero, D., Rudan, I., Rotter, J.I., Rose, L.M., Robino, A., Ripatti, S., Riese, H., Ried, J.S., Ridker, P.M., Rice, K., Rettig, R., Ren, M., Raitakari, O.T., Nguyen, Q.T., Pramstaller, P.P., Polasek, O., Peters, A., Perola, M., Penninx, B.W.J.H., Pattie, A., Palotie, A., Palmas, W., Padmanabhan, S., Org, E., O’Reilly, P.F., Oostra, B.A., Oldehinkel, A.J., Nutile, T., Nolte, I.M., Niiranen, T., Nelson, C.P., Nandakumar, P., Nalls, M.A., Munson, P.J., Morrison, A.C., Morris, A.P., Morgan, A., Milaneschi, Y., Marten, J., Marrugat, J., Mamasoula, C., Mahajan, A., Lyytikäinen, L.-P., Lu, Y., Lopez, L.M., Loos, R.J.F., Liu, Y.M., Lindgren, C.M., Lind, L., Lin, L., Liewald, D.C.M., Lehtimäki, T., Lehne, B., Launer, L.J., Larson, M., Laan, M., Kutalik, Z., Kristiansson, K., Koskinen, S., Kooner, J.S., Kolcic, I., Knight, J., Knekt, P., Khaw, K.-T., Keavney, B.D., Kathiresan, S., Kähönen, M., Jula, A., Jukema, J.W., Jousilahti, P., Joshi, P.K., Johnson, A.D., Johansson, Å., Joehanes, R., Jarvelin, M.-R., Jansen, R., James, A., Ingelsson, E., Hwang, S.-J., Huffman, J.E., Hottenga, J.-J., Hofman, A., Hofer, E., Hicks, A.A., Havulinna, A.S., Hartman, C.A., Harris, S.E., Harris, T.B., Hamsten, A., Gyllensten, U., Guo, X., Gudnason, V., Gow, A.J., Goel, A., Girotto, G., Gieger, C., Giedraitis, V., Gasparini, P., Gandin, I., Franco, O.H., Frånberg, M., Ferreira, T., Erzurumluoglu, A.M., Enroth, S., Elosua, R., Ehret, G.B., Dörr, M., Demirkale, C.Y., Del Greco M, F., Deelen, J., Deary, I.J., Geus, E.J., Borst, M.H., Davies, G., Cordell, H.J., Collins, F., Cocca, M., Ciullo, M., Chauhan, G., Chambers, J.C., Chakravarti, A., Campbell, H., Campbell, A., Brumat, M., Braund, P.S., Bottinger, E.P., Boomsma, D.I., Boerwinkle, E., Boehnke, M., Bochud, M., Blake, T., Bis, J.C., Batini, C., Barbieri, C.M., Ayers, K.L., Arking, D.E., Amin, N., Abecasis, G., Thom, S., Stanton, A., Shields, D.C., Poulter, N.R., Paré, G., Noordam, R., Morris, A.D., Menni, C., Farrall, M., Doney, A.S.F., de Mutsert, R., Connell, J., Amouyel, P., Zhao, J.-H., Willems, S.M., Verweij, N., Thériault, S., Surendran, P., Shah, N., Sargurupremraj, M., Qian, Y., Prins, B.P., Oldmeadow, C., Mangino, M., Luan, J., Lin, W.-Y., Li-Gao, R., Jackson, A.U., Holliday, E.G., Giulianini, F., Ding, J., Debette, S., Boutin, T., Almgren, P., Milani, L., Mägi, R., Esko, T., Kovesdy, C.P., Tsao, P.S., Wilson, P.W.F., Gaziano, J.M., Cho, K., Sun, Y.V., Velez Edwards, D.R., Giri, A., Hellwege, J.N., Tzanis, E., Witkowska, K., Evangelou, M., Ng, F.L., Karaman, I., Cabrera, C.P., Dimou, N., Ntritsos, G., Gao, H., Pazoki, R., Mifsud, B., Mosen-Ansorena, D., Warren, H.R., Evangelou, E., Nature Genetics, 2018, 10.1038/s41588-018-0205-x

Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis, Arsenault, B.J., Poggio, P., Thériault, S., Camera, M., Bossé, Y., Schott, J.-J., Thanassoulis, G., Mathieu, P., Smith, J.G., Esko, T., Pibarot, P., Polvani, G., Engert, J.C., Wareham, N.J., Messika-Zeitoun, D., Le Tourneau, T., Clavel, M.-A., Mass, E., Capoulade, R., Rigade, S., Manikpurage, H.D., Martinsson, A., Abner, E., Chen, H.Y., Dina, C., Boekholdt, S.M., Moschetta, D., Valerio, V., Perrot, N., JACC: Basic to Translational Science, 2020, 10.1016/j.jacbts.2020.05.004

Multi-ethnic genome-wide association study for atrial fibrillation, Ellinor, P.T., Lunetta, K.L., Lubitz, S.A., Zeng, L., Zeller, T., Yoneda, Z.T., Yao, J., Yang, P.-S., Worrall, B.B., Woo, D., Wong, J.A., Wiggins, K.L., Wells, Q.S., Weiss, S., Weiss, R., Weijs, B., Weeke, P.E., Wang, B., Völker, U., Vlachopoulou, E., Verweij, N., Van Wagoner, D.R., Van Gelder, I.C., Van Der Harst, P., Uitterlinden, A.G., Tveit, A., Tucker, N.R., Trompet, S., Thériault, S., Teumer, A., Teder-Laving, M., Taylor, K.D., Tanriverdi, K., Tanaka, T., Svendsen, J.H., Sun, H., Sun, A., Stricker, B.H., Sotoodehnia, N., Soliman, E.Z., Smith, N.L., Smith, J.D., Smith, J.G., Smith, B.H., Smith, A.V., Slowik, A., Sinner, M.F., Sinisalo, J., Siland, J.E., Shoemaker, M.B., Shim, J., Shalaby, A.A., Shah, S., Shaffer, C., Seppälä, I., Scott, S.A., Schurman, C., Schunkert, H., Schramm, K., Schnabel, R.B., Sandhu, R.K., Saba, S., Rotter, J.I., Rost, N., Rosenberg, M.A., Rosand, J., Roden, D.M., Risch, L., Rienstra, M., Ridker, P.M., Ribasés, M., Refsgaard, L., Rader, D.J., Pullinger, C.R., Pulit, S.L., Psaty, B.M., Porteous, D., Pereira, A., Pera, J., Pedersen, N.L., Paré, G., Pak, H.-N., Padmanabhan, S., Orho-Melander, M., Olesen, M.S., Oellers, H., Noordam, R., Nilsson, P., Nikus, K., Niemeijer, M.N., Newton-Cheh, C., Neumann, B., Nazarian, S., Natale, A., Müller-Nurasyid, M., Morris, A.P., Morley, M.P., Montgomery, J.A., Mohanty, S., Melander, O., McManus, D.D., März, W., Margulies, K.B., Margolin, L., Marcus, G.M., Mansur, A.J., Malik, R., Mahajan, A., Magnusson, P.K., Macfarlane, P.W., Lyytikäinen, L.-P., Lu, Y., Low, S.-K., Loos, R.J.F., London, B., Lokki, M.-L., Lindgren, C.M., Lind, L., Lin, H., Lin, H.J., Lim, H.E., Li, M., Lemaitre, R.N., Leineweber, K., Lehtimäki, T., Laurikka, J., Launer, L.J., Kubo, M., Krieger, J.E., Knight, S., Kleber, M.E., Kirchhof, P., Kietselaer, B.L., Kessler, T., Kavousi, M., Katschnig-Winter, P., Kathiresan, S., Kastrati, A., Kane, J.P., Kamatani, Y., Kähönen, M., Kääb, S., Jukema, J.W., Johnson, R., Jimenez-Conde, J., Ito, K., Ipek, E.G., Ingelsson, E., Huffman, J., Huang, P.L., Huang, J., Horimoto, A.R.V.R., Hofman, A., Hocking, L.J., Hernesniemi, J., Heckbert, S.R., Hayward, C., Harris, T.B., Hamsten, A., Gutmann, R., Gustafsson, S., Gupta, N., Guo, X., Gudnason, V., Grewal, R.P., Geelhoed, B., Franco, O.H., Ford, I., Felix, S.B., Fatkin, D., Eskola, M., Esko, T., Esa, N., Dudley, S.C., Dudink, E.A., Dörr, M., Dichgans, M., Denny, J.C., Delgado, G., Darbar, D., Daniels, B.R., Damrauer, S.M., Cutler, M.J., Crijns, H.J., Cook, J., Conen, D., Cole, J.W., Chung, M.K., Christophersen, I.E., Choi, S.H., Choi, E.-K., Chen, Y.-D.I., Chen, L.Y., Chasman, D.I., Carlquist, J., Cappola, T.P., Campbell, A., Calkins, H., Brody, J.A., Bottinger, E.B., Boerwinkle, E., Bloom, H.L., Bis, J.C., Bihlmeyer, N.A., Benjamin, E.J., Bartz, T.M., Barnard, J., Arking, D.E., Aragam, K.G., Anderson, C.D., Alonso, A., Almgren, P., Ahlberg, G., Albert, C.M., Aeschbacher, S., Weng, L.-C., Chaffin, M.D., Roselli, C., Nature Genetics, 2018, 10.1038/s41588-018-0133-9

Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (Nature Genetics, (2020), 52, 12, (1314-1332), 10.1038/s41588-020-00713-x), Howson, J.M.M., Munroe, P.B., Newton-Cheh, C., Levy, D., Chasman, D.I., Boerwinkle, E., Stefansson, K., Saleheen, D., Psaty, B.M., O’Donnell, C.J., Morrison, A.C., Morris, A.P., Manning, A.K., Liu, C., Lindgren, C.M., Holm, H., Edwards, T.L., Danesh, J., Caulfield, M.J., Butterworth, A.S., Tomaszewski, M., Langenberg, C., Wareham, N.J., O’Donnell, C.J., Hung, A.M., Edwards, T.L., Wilson, P.W.F., Tsao, P.S., Sun, Y.V., Kovesdy, C.P., Gaziano, J.M., Cho, K., Edwards, D.R.V., Giri, A., Hellwege, J.N., Charchar, F.J., Zeggini, E., Weir, D.R., Völker, U., Virtamo, J., Verweij, N., Ramachandran, V.S., van der Meer, P., van der Harst, P., Zeggini, E., Prins, B.P., Tobin, M.D., Timpson, N.J., Lakka, T.A., Taylor, K.D., Sebert, S., Starr, J.M., Spector, T.D., Soranzo, N., Smith, B.H., Sheu, W.H.-H., Sattar, N., Samani, N.J., Salomaa, V., Rudan, I., Rotter, J.I., Rosendaal, F.R., Rolandsson, O., Ridker, P.M., Rice, K., Relton, C.L., Province, M.A., Prentice, A.M., Porteous, D.J., Polasek, O., Palmas, W., Padmanabhan, S., Packard, C.J., Orho-Melander, M., Nordestgaard, B.G., Murray, A.D., Mohlke, K.L., Melander, O., McCarthy, M.I., Laakso, M., Majumder, A.S., Loos, R.J.F., Lind, L., Launer, L.J., Kooperberg, C., Kooner, J.S., Kee, F., Kardia, S.L.R., Jukema, J.W., Järvelin, M.-R., Tuomilehto, J., Ingelsson, E., Herzig, K.-H., Hennig, B.J., Hayward, C., Harris, T.B., Gudnason, V., Groop, L., Gaunt, T.R., Gambaro, G., Frossard, P., Franks, S., Franks, P.W., Fornage, M., Ford, I., Ferrières, J., Felix, S.B., Wareham, N.J., Rolandsson, O., Franks, P.W., McCarthy, M.I., Langenberg, C., Danesh, J., Butterworth, A.S., Elliott, P., Di Angelantonio, E., Deloukas, P., Dedoussis, G., Deary, I.J., Boer, R.A., Davey Smith, G., Correa, A., Conen, D., Chowdhury, R., Chen, Y.-D.I., Chambers, J.C., Buring, J.E., Bottinger, E.P., Bots, M.L., Boehnke, M., Blakemore, A.I., Barnes, M.R., Asselbergs, F.W., Amouyel, P., Almgren, P., Aliya, N., Zhang, H., Yonova-Doing, E., Witte, D.R., Wilson, P.W.F., Willer, C.J., Vergnaud, A.-C., Vaartjes, I., Tzoulaki, I., Turner, S.T., Tuomi, T., Tsao, P.S., Trabetti, E., Esko, T., Thorgeirsson, G., Sundstrom, J., Sun, Y.V., Skaaby, T., Sigurdsson, E.L., Sever, P.S., Schreiner, P.J., Rossouw, J., Rettig, R., Renström, F., Mägi, R., Rayner, N.W., Rasmussen, K.L., Rasheed, A., Poulter, N., Peters, J., Pedersen, O., Papanicolaou, G.J., Palmer, C.N.A., Neville, M.J., Nadkarni, G., Moitry, M., Martin, L.W., Linneberg, A., Verweij, N., van der Meer, P., van der Harst, P., de Boer, R.A., Lee, W.-J., Lee, I.-T., Lannfelt, L., Laatikainen, T., Kuulasmaa, K., Kovesdy, C.P., Koistinen, H.A., Karpe, F., Käräjämäki, A.M., Kamat, M., Kajantie, E., Jousilahti, P., Jørgensen, M.E., Heiss, G., Have, C.T., Hansen, T., Hallmans, G., Grove, M.L., Grarup, N., Gaziano, J.M., Farmaki, A.-E., Eiriksdottir, G., Dörr, M., Dominiczak, A.F., Mutsert, R., Connell, J., Cho, K., Christensen, C., Burgess, S., Braund, P.S., Brandslund, I., Bork-Jensen, J., Bonnycastle, L.L., Blankenberg, S., Asllanaj, E., Aeschbacher, S., Evangelou, E., Zhao, W., Zhao, W., Zhao, J.-H., Zhang, W., Yu, B., Young, R., Yao, J., Willems, S.M., Weiss, S., Veronesi, G., Velez Edwards, D.R., Varga, T.V., Trompet, S., Thorsteinsdottir, U., Thériault, S., Sulem, P., Stanáková, A., Staley, J.R., Smith, J.A., Smith, A.V., Sim, X., Sepúlveda, N., Richardson, T.G., Richard, M., Rauramaa, R., Poveda, A., Perola, M., Paul, D.S., Paré, G., Müller-Nurasyid, M., Mosen-Ansorena, D., Mook-Kanamori, D.O., Menni, C., Mei, H., Masca, N.G.D., Malerba, G., Mahajan, A., Luan, J., Lu, Y., Lotta, L.A., Lindström, J., Li-Gao, R., Larson, M.G., Kontto, J., Kanoni, S., Hwang, S.-J., Huffman, J.E., Helgadottir, A., Havulinna, A.S., Harris, S.E., Guo, X., Gudbjartsson, D.F., Giulianini, F., Giannakopoulou, O., Gao, H., Franceschini, N., Foley, C.N., Ferreira, T., Fava, C., Fauman, E.B., Faul, J.D., Nielsen, S.F., Drenos, F., Warren, H.R., Daw, E.W., Brody, J.A., Braithwaite, V.S., Bis, J.C., Bielak, L.F., Auer, P.L., Akbarov, A., Eales, J.M., Cabrera, C.P., Stewart, I.D., Prins, B.P., Liu, D.J., Thorleifsson, G., Tragante, V., Giri, A., Hellwege, J.N., Cartwright, J.H., Kraja, A.T., Yao, C., Mifsud, B., Chen, L., Cook, J., Karthikeyan, S., Ntalla, I., Lahrouchi, N., Feofanova, E.V., Surendran, P., Nature Genetics, 2021, 10.1038/s41588-021-00832-z

Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification, Arsenault, B.J., Bossé, Y., Clavel, M.-A., Thanassoulis, G., Schott, J.-J., Pibarot, P., Mathieu, P., Dweck, M.R., Wareham, N.J., Khaw, K.-T., Engert, J.C., Nadeau, M., Guimond, J., Tessier, M., Trottier, M., Messika-Zeitoun, D., Le Tourneau, T., Capoulade, R., Poulin, A., Després, A.-A., Rigade, S., Boekholdt, S.M., Chen, H.Y., Dina, C., Thériault, S., Perrot, N., JAMA Cardiology, 2019, 10.1001/jamacardio.2019.1581

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals, Edwards, T.L., Hung, A.M., O’Donnell, C.J., Susztak, K., Velez Edwards, D.R., Tsao, P.S., Wilson, P.W.F., Concato, J., Gaziano, J.M., Elliott, P., Caulfield, M.J., Newton-Cheh, C., Munroe, P.B., Howson, J.M.M., Psaty, B.M., Denny, J.C., Dedoussis, G., Herzig, K.-H., Lindgren, C., Siew, E.E., Matheny, M.E., Xu, Y., Smith, J.C., Wei, W.-Q., Timpson, N.J., Hennig, B.J., Jarvelin, M.-R., Spector, T.D., Hayward, C., Schlessinger, D., Cucca, F., van der Harst, P., Mook-Kanamori, D.O., Melander, O., Ridker, P.M., Chasman, D.I., Attia, J., Palmer, C.N.A., Conen, D., Wareham, N.J., Langenberg, C., Scott, R.A., Sever, P., Zeggini, E., Laakso, M., Poulter, N.R., Farrall, M., Amouyel, P., Kraja, A., Richardson, T.G., Sepúlveda, N., Liu, C., Lahrouchi, N., Karthikeyan, S., Cook, J.P., Surendran, P., Feofanova, E., Ntalla, I., Mangino, M., Boutin, T.S., Verweij, N., Li-Gao, R., Almgren, P., Oldmeadow, C., Shah, N., Thériault, S., Willems, S.M., Zhao, J.-H., Luan, J., Scott, L.J., Boehnke, M., Debette, S., Sargurupremraj, M., Akwo, E.A., Mautz, B.S., Shrestha, R., Wain, L.V., Cabrera, C.P., Evangelou, E., Wang, Y., Cho, K., Klarin, D., DuVall, S.L., Damrauer, S.M., Birdwell, K.A., Chung, C.P., Roumie, C.L., Robinson-Cohen, C., Wilson, O.D., Sun, Y.V., Kovesdy, C.P., Torstenson, E.S., Warren, H.R., Qiu, C., Park, J., Keaton, J.M., Hellwege, J.N., Giri, A., Nature Genetics, 2019, 10.1038/s41588-018-0303-9

A false-positive troponin assay leading to the misdiagnosis of myopericarditis, Steinberg, C., Thériault, S., Turgeon, P.Y., Laguë, M., CMAJ, 2022, 10.1503/CMAJ.211842

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation, Yohan Bossé, Patrick Mathieu, Tõnu Esko, Nicholas J. Wareham, S. Matthijs Boekholdt, Benoit J. Arsenault, Philippe Pibarot, Marie-Annick Clavel, François Dagenais, Manel Dahmene, Déborah Argaud, Lily Frenette, Nathalie Gaudreault, Dominique K. Boudreau, Mewen Briend, Pardis Zamani, Ursula Houessou, Hasanga D. Manikpurage, Jian’an Luan, Erik Abner, Zhonglin Li, Sébastien Thériault, Nature Communications, 2024, 10.1038/s41467-024-46639-4

Mendelian randomization of circulating proteome identifies actionable targets in heart failure, Mathieu, P., Arsenault, B.J., Thériault, S., Bossé, Y., Sylla, M.S., Mathieu, S., Moncla, L.-H.M., BMC Genomics, 2022, 10.1186/s12864-022-08811-2

Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve, Patrick Mathieu, Yohan Bossé, Sébastien Thériault, Zhonglin Li, Valentin Bon-Baret, Ghada Mkannez, Marie-Chloé Boulanger, Déborah Argaud, Arnaud Chignon, PLOS Genetics, 2022, 10.1371/journal.pgen.1010010

Linking preeclampsia and cardiovascular disease later in life, Forest, J.-C., Lafond, J., Rousseau, F., Laroche, M., Bujold, E., Thériault, S., Charland, M., Giguère, Y., Clinical Chemistry and Laboratory Medicine, 2012, 10.1515/CCLM.2011.764

Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery ddisease, Mathieu, P., Thériault, S., Arsenault, B., Bossé, Y., Voisine, P., Argaud, D., Rufiange, A., Mathieu, S., Chignon, A., ResearchSquare, 2021, 10.21203/rs.3.rs-978033

A Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men, Sébastien Thériault, Benoit J. Arsenault, Yohan Bossé, Patrick Mathieu, Christian Couture, Zhonglin Li, Nicolas Perrot, Aida Eslami, Hasanga D. Manikpurage, 2021, 10.1101/2021.04.25.21256083

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders, Elliott, P., Schumann, G., Desrivières, S., Rothenfluh, A., Matthews, P.M., Bell, J.D., Tzoulaki, I., Levy, D., Wilson, J.F., Weir, D.R., Verweij, N., Spector, T.D., Scott, L.J., Samani, N.J., Rudan, I., Raitakari, O.T., Psaty, B.M., Penninx, B.W.J.H., Oldehinkel, A.J., Martin, N.G., Morrison, A.C., Mohlke, K.L., McIntosh, A.M., Lehtimäki, T., Lahti, J., Laakso, M., Kuusisto, J., Kühne, M., Kardia, S.L.R., Kähönen, M., Jarvelin, M.-R., Heath, A.C., Hayward, C., Hartman, C.A., van der Harst, P., Guo, X., Grabe, H.J., Eriksson, J.G., Conen, D., Campbell, H., Boehnke, M., Blakemore, A.I., Veijola, J., Snieder, H., Rotter, J.I., Risch, L., Männikkö, M., Liu, C., Auvinen, J., Arking, D.E., Zhao, W., Yu, B., Yao, J., Wood, A., Whitfield, J.B., Vangipurapu, J., Thériault, S., Tuominen, S., Teumer, A., Stančáková, A., Smith, J.A., Ratliff, S.M., Porteous, D., Polasek, O., Perälä, M.-M., Nolte, I.M., Nelson, C.P., Milaneschi, Y., Mangino, M., Lyytikäinen, L.-P., Lind, P.A., Lemaitre, R.N., Joshi, P.K., Kentistou, K.A., Jackson, A.U., Homuth, G., Faul, J.D., Dimou, N., Clarke, T.-K., Brody, J.A., Brown, M.R., Braund, P.S., Baumeister, S.E., Bartz, T.M., Aeschbacher, S., Luo, Q., Elliott, J., Karaman, I., Yiorkas, A.M., Koskeridis, F., Suzuki, H., Pazoki, R., Butts, A.R., Blakeley, P., Ntritsos, G., Chu, C., Gao, H., Evangelou, E., Nature Human Behaviour, 2019, 10.1038/s41562-019-0653-z

Découvrez nos professeurs et professeures!

Sébastien Thériault

Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)

Médecine régénératrice et médecine moléculaire

Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Génétique humaine

Santé circulatoire et respiratoire

Projets de recherche

Publications

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Encadrement d'étudiant(e)s pour les programmes suivants :

Médecine moléculaire

Sciences cliniques et biomédicales

Disponibilité d'encadrement d'étudiant(e)s

Direction et personnes-ressources