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Serge Rivest

Professeur titulaire

Directeur(trice), Centre de recherche du CHU de Québec - Université Laval

Directeur(trice), Centres de recherche du CHU de Québec - UL

Serge Rivest
serge.rivest@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
Centres de recherche du CHU de Québec - UL
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Immunologie-infectiologie
Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Maladies infectieuses et immunitaires
  • Développement de vaccins
  • Immunothérapie
  • Maladies auto-immunes
  • Système immunitaire
Neurosciences, santé mentale et toxicomanies
  • Démences
  • Maladie d'Alzheimer
  • Maladies neurodégénératives
  • Maladies neuroimmunologiques
  • Sclérose en plaques
Vieillissement
  • Dégénérescence cellulaire
  • Vieillissement cellulaire

Projets de recherche

  • Chaire de recherche du Canada en neuroimmunologie - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2023-07-01 au 2030-06-30
  • Acquisition d’équipements pour les activités de recherche en oncologie de précision au Nouveau Complexe hospitalier - CHU de Québec – Université Laval – CHUL, Ministère de l'Économie et de l'Innovation - Programme de soutien aux organismes de recherche et d'innovation (PSO) - Volet 4: Soutien au financement d'infrastructures de recherche et d'innovation, chercheur principal - 2022-03-24 au 2027-03-23
  • Chercheur d'un jour - Conseil de recherches en sciences naturelles et génie Canada - PromoScience, chercheur principal - 2023-01-01 au 2025-12-31
  • Therapeutic properties of innate immune cells and system for brain diseases - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-04-01 au 2025-03-31
  • Chaire de recherche du Canada en neuroimmunologie - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2016-07-01 au 2023-06-30
  • Chercheur d'un jour - Conseil de recherches en sciences naturelles et génie Canada - PromoScience, chercheur principal - 2021-01-01 au 2022-12-31
  • Programme chercheur-e d'un jour - Fonds de recherche du Québec - Société et culture - Subventions générales de recherche et projets spéciaux (non partageable au prorata), co-chercheur - 2018-04-01 au 2021-03-31
  • Développement de marqueurs génétiques de maladies rares. - Fondation du CHU de Québec, chercheur principal - 2016-02-11 au 2020-02-10

Publications

  • Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS, , Journal of neurochemistry, 2001, 10.1046/j.1471-4159.2001.00603.x
  • Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/JNEUROSCI.3016-07.2007
  • A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease, , Journal of molecular cell biology, 2013, 10.1093/jmcb/mjt028
  • Alzheimer's disease: microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation, , Expert opinion on therapeutic targets, 2020, 10.1080/14728222.2020.1738391
  • IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults, , Frontiers in cellular neuroscience, 2013, 10.3389/fncel.2013.00009
  • Microglia Purinoceptor P2Y6: An Emerging Therapeutic Target in CNS Diseases, , Cells, 2020, 10.3390/cells9071595
  • Stimulation of monocytes, macrophages, and microglia by amphotericin B and macrophage colony-stimulating factor promotes remyelination, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, 10.1523/JNEUROSCI.1797-14.2015
  • Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, 10.1096/fj.00-0339com
  • The hematopoietic cytokine M-CSF as a cure for Alzheimer's disease, , Medecine sciences : M/S, 2009, 10.1051/medsci/2009258-9666
  • Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease, , Neuropharmacology, 2011, 10.1016/j.neuropharm.2011.01.035
  • A functional analysis of EP4 receptor-expressing neurons in mediating the action of prostaglandin E2 within specific nuclei of the brain in response to circulating interleukin-1beta, , Journal of neurochemistry, 2000, 10.1046/j.1471-4159.2000.0742134.x
  • Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain, , Journal of innate immunity, 2009, 10.1159/000225990
  • The LPS receptor (CD14) links innate immunity with Alzheimer's disease, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, 10.1096/fj.03-0364fje
  • PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system, , Life science alliance, 2022, 10.26508/lsa.202201467
  • Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains, , Infection and immunity, 2002, 10.1128/IAI.70.4.1997-2009.2002
  • Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain: anatomical evidence of distinct roles of each subtype, , Journal of neurobiology, 1998, 10.1002/(sici)1097-4695(19980905)36:33.0.co;2-v
  • Inefficient clearance of myelin debris by microglia impairs remyelinating processes, , The Journal of experimental medicine, 2015, 10.1084/jem.20141656
  • Arachidonate Metabolites in the Neurophysiological System: The Fever Pathway, , 2004
  • QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis, , Cell reports, 2020, 10.1016/j.celrep.2020.108560
  • Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 10.1523/JNEUROSCI.1146-08.2008
  • Effect of dexfenfluramine on the transcriptional activation of CRF and its type 1 receptor within the paraventricular nucleus of the rat hypothalamus, , British journal of pharmacology, 1996, 10.1111/j.1476-5381.1996.tb16692.x
  • Hypothalamic paraventricular nucleus lesions do not prevent anorectic effect of exercise in male rats, , The American journal of physiology, 1990, 10.1152/ajpregu.1990.259.3.R579
  • Role of Macrophage Colony-Stimulating Factor Receptor on the Proliferation and Survival of Microglia Following Systemic Nerve and Cuprizone-Induced Injuries, , Frontiers in immunology, 2020, 10.3389/fimmu.2020.00047
  • Role of cyclo-oxygenase pathways in the stimulatory influence of immune challenge on the transcription of a specific CRF receptor subtype in the rat brain, , Journal of chemical neuroanatomy, 1996, 10.1016/0891-0618(95)00106-9
  • Effects of corticotropin-releasing factor on energy balance in rats are sex dependent, , The American journal of physiology, 1989, 10.1152/ajpregu.1989.257.6.R1417
  • Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis, , The Journal of general virology, 2012, 10.1099/vir.0.041046-0
  • Triggering Innate Immune Receptors as New Therapies in Alzheimer's Disease and Multiple Sclerosis, , Cells, 2021, 10.3390/cells10082164
  • Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection, , Journal of immunology (Baltimore, Md. : 1950), 2007, 10.4049/jimmunol.179.3.1842
  • Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation, , The European journal of neuroscience, 1999, 10.1046/j.1460-9568.1999.00682.x
  • Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, 10.1007/s13311-020-00998-0
  • The role of exercise in thermogenesis and energy balance, , Canadian journal of physiology and pharmacology, 1989, 10.1139/y89-064
  • An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
  • Differential effects of central and peripheral injection of interleukin-1 beta on brain c-fos expression and neuroendocrine functions, , Brain research, 1992, 10.1016/0006-8993(92)91424-d
  • Immune receptors involved in Streptococcus suis recognition by dendritic cells, , PloS one, 2012, 10.1371/journal.pone.0044746
  • Regulation of innate immune responses in the brain, , Nature reviews. Immunology, 2009, 10.1038/nri2565
  • Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis, , Behavioural brain research, 2011, 10.1016/j.bbr.2011.07.034
  • Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke, , Nature medicine, 2009, 10.1038/nm.1927
  • Role of the chemokine receptors CCR2 and CX3CR1 in an experimental model of thrombotic stroke, , Brain, behavior, and immunity, 2018, 10.1016/j.bbi.2018.03.008
  • CX3CR1 in multiple sclerosis, , Oncotarget, 2015, 10.18632/oncotarget.4650
  • Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer's Disease and Multiple Sclerosis, , Frontiers in cellular neuroscience, 2019, 10.3389/fncel.2019.00355
  • An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, 10.1096/fj.04-2030fje
  • Effects of exercise on energy balance in meal-fed mice, , Physiology & behavior, 1991, 10.1016/0031-9384(91)90043-n
  • Immunotherapy for neurological diseases, , Clinical immunology (Orlando, Fla.), 2008, 10.1016/j.clim.2008.04.003
  • Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
  • C-fos mRNA pattern and corticotropin-releasing factor neuronal activity throughout the brain of rats injected centrally with a prostaglandin of E2 type, , Journal of neuroimmunology, 1996, 10.1016/s0165-5728(96)00114-2
  • Luteinizing hormone secretion and corticotropin-releasing factor gene expression in the paraventricular nucleus of rhesus monkeys following cortisol synthesis inhibition, , Endocrinology, 1997, 10.1210/endo.138.6.5171
  • Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 10.1523/JNEUROSCI.1642-11.2011
  • How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli, , Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, 10.1046/j.1525-1373.2000.22304.x
  • Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease, , Brain : a journal of neurology, 2009, 10.1093/brain/awn331
  • Role of adaptor protein MyD88 in TLR-mediated preconditioning and neuroprotection after acute excitotoxicity, , Brain, behavior, and immunity, 2015, 10.1016/j.bbi.2015.02.019
  • Unraveling the molecular details involved in the intimate link between the immune and neuroendocrine systems, , Experimental biology and medicine (Maywood, N.J.), 2004, 10.1177/153537020422901003
  • Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, 10.1096/fj.04-1517fje
  • Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta, , Journal of neurochemistry, 1997, 10.1046/j.1471-4159.1997.69041668.x
  • Stress and interleukin-1 beta-induced activation of c-fos, NGFI-B and CRF gene expression in the hypothalamic PVN: comparison between Sprague-Dawley, Fisher-344 and Lewis rats, , Journal of neuroendocrinology, 1994, 10.1111/j.1365-2826.1994.tb00559.x
  • New Therapeutic Avenues of mCSF for Brain Diseases and Injuries, , Frontiers in cellular neuroscience, 2018, 10.3389/fncel.2018.00499
  • In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain, , Endocrinology, 2002, 10.1210/en.2002-220598
  • Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/JNEUROSCI.3027-07.2007
  • Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system, , The Journal of cell biology, 2003, 10.1083/jcb.200301097
  • Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.4901-12.2013
  • A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600, , The Journal of biological chemistry, 2013, 10.1074/jbc.M113.483107
  • Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994
  • Involvement of corticotropin-releasing factor in the anorexia induced by exercise, , Brain research bulletin, 1990, 10.1016/0361-9230(90)90270-a
  • Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain, , Journal of neurochemistry, 1998, 10.1046/j.1471-4159.1998.70020452.x
  • Whole-exome sequencing identifies homozygous mutation in TTI2 in a child with primary microcephaly: a case report, , BMC neurology, 2020, 10.1186/s12883-020-01643-1
  • Modulation of the innate immune response by NMDA receptors has neuropathological consequences, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
  • The role of microglial cell subsets in Alzheimer's disease, , Current Alzheimer research, 2011, 10.2174/156720511795256035
  • Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy, , Neurobiology of disease, 2004, 10.1016/j.nbd.2004.03.010
  • Microglia: Senescence Impairs Clearance of Myelin Debris, , Current biology : CB, 2016, 10.1016/j.cub.2016.06.066
  • High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice, , Oncotarget, 2016, 10.18632/oncotarget.12179
  • Lesions of hypothalamic PVN partially attenuate stimulatory action of alcohol on ACTH secretion in rats, , The American journal of physiology, 1994, 10.1152/ajpregu.1994.266.2.R553
  • Neuroprotective role of the innate immune system by microglia, , Neuroscience, 2007, 10.1016/j.neuroscience.2007.02.055
  • Molecular mechanisms and neural pathways mediating the influence of interleukin-1 on the activity of neuroendocrine CRF motoneurons in the rat, , International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1995, 10.1016/0736-5748(94)00063-9
  • A Homozygous Deep Intronic Mutation Alters the Splicing of Nebulin Gene in a Patient With Nemaline Myopathy, , Frontiers in neurology, 2021, 10.3389/fneur.2021.660113
  • Microglia Ontology and Signaling, , Frontiers in cell and developmental biology, 2016, 10.3389/fcell.2016.00072
  • The combination of valacyclovir with an anti-TNF alpha antibody increases survival rate compared to antiviral therapy alone in a murine model of herpes simplex virus encephalitis, , Antiviral research, 2013, 10.1016/j.antiviral.2013.10.007
  • A founder mutation in the gene in families from Saguenay-Lac-St-Jean region affected by a pyridoxine-dependent epilepsy, , JIMD reports, 2021, 10.1002/jmd2.12196
  • Fluoxetine induces the transcription of genes encoding c-fos, corticotropin-releasing factor and its type 1 receptor in rat brain, , Neuroscience, 1998, 10.1016/s0306-4522(98)00147-x
  • CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 10.1523/JNEUROSCI.0299-11.2011
  • Oncostatin M is a novel glucocorticoid-dependent neuroinflammatory factor that enhances oligodendrocyte precursor cell activity in demyelinated sites, , Brain, behavior, and immunity, 2010, 10.1016/j.bbi.2010.01.005
  • Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain, , The American journal of physiology, 1998, 10.1152/ajpregu.1998.275.5.R1438
  • What is the cellular source of prostaglandins in the brain in response to systemic inflammation? Facts and controversies, , Molecular psychiatry, 1999
  • Tissue-Plasminogen Activator Attenuates Alzheimer's Disease-Related Pathology Development in APPswe/PS1 Mice, , Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, 10.1038/npp.2015.279
  • Glucocorticoids play a fundamental role in protecting the brain during innate immune response, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
  • Reversible increase in energy deposition following castration induced by a gonadotropin releasing hormone agonist, , International journal of obesity, 1991
  • Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury, , Journal of neurochemistry, 2007, 10.1111/j.1471-4159.2007.04524.x
  • Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1, , European journal of immunology, 2005, 10.1002/eji.200526037
  • CRF alters the infundibular LHRH secretory system from the medial preoptic area of female rats: possible involvement of opioid receptors, , Neuroendocrinology, 1993, 10.1159/000126365
  • Molecular and cellular immune mediators of neuroprotection, , Molecular neurobiology, 2006, 10.1385/MN:34:3:221
  • Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 10.1523/JNEUROSCI.4786-03.2004
  • Immune System–Neuroendocrine Interactions, , 2009
  • Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis, , Journal of neuroimmunology, 2011, 10.1016/j.jneuroim.2011.02.005
  • Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor, , Journal of immunology (Baltimore, Md. : 1950), 2000, 10.4049/jimmunol.165.4.2232
  • The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease, , Frontiers in physiology, 2013, 10.3389/fphys.2013.00045
  • Inflammatory Monocytes and Neutrophils Regulate Streptococcus suis-Induced Systemic Inflammation and Disease but Are Not Critical for the Development of Central Nervous System Disease in a Mouse Model of Infection, , Infection and immunity, 2020, 10.1128/IAI.00787-19
  • Stress-induced genetic expression of a selective corticotropin-releasing factor-receptor subtype within the rat ovaries: an effect dependent on the ovulatory cycle, , Biology of reproduction, 1995, 10.1095/biolreprod53.6.1417
  • Role of inflammation in the neurobiology of stem cells, , Neuroreport, 2004, 10.1097/00001756-200410250-00001
  • MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1, , The Journal of biological chemistry, 2009, 10.1074/jbc.M807530200
  • Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination, , Annals of neurology, 2012, 10.1002/ana.23599
  • Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14, , Journal of immunology (Baltimore, Md. : 1950), 2002, 10.4049/jimmunol.169.6.3370
  • Expression of corticotropin-releasing factor and its receptors in the brain of lean and obese Zucker rats, , Endocrinology, 1996, 10.1210/endo.137.11.8895348
  • Alcohol-induced inhibition of LH secretion in intact and gonadectomized male and female rats: possible mechanisms, , Alcoholism, clinical and experimental research, 1992, 10.1111/j.1530-0277.1992.tb01896.x
  • Activation of the nuclear factor kappa B (NF-kappaB) and cyclooxygenase-2 (COX-2) genes in cerebral blood vessels in response to systemic inflammation, , Molecular psychiatry, 1999
  • Corticotropin-releasing factor activates c-fos, NGFI-B, and corticotropin-releasing factor gene expression within the paraventricular nucleus of the rat hypothalamus, , Molecular endocrinology (Baltimore, Md.), 1993, 10.1210/mend.7.10.8264665
  • Irradiation does not compromise or exacerbate the innate immune response in the brains of mice that were transplanted with bone marrow stem cells, , Stem cells (Dayton, Ohio), 2007, 10.1634/stemcells.2007-0508
  • Does circulating leptin have the ability to cross the blood-brain barrier and target neurons directly?, , Endocrinology, 2002, 10.1210/en.2002-220655
  • Characterization of the early neuroinflammation after spinal cord injury in mice, , Journal of neuropathology and experimental neurology, 2007, 10.1097/01.jnen.0000248552.07338.7f
  • Estradiol is required for a proper immune response to bacterial and viral pathogens in the female brain, , Journal of immunology (Baltimore, Md. : 1950), 2005, 10.4049/jimmunol.174.10.6391
  • Triggering of NOD2 Receptor Converts Inflammatory Ly6C into Ly6C Monocytes with Patrolling Properties, , Cell reports, 2017, 10.1016/j.celrep.2017.08.009
  • Central mechanisms and sites of action involved in the inhibitory effects of CRF and cytokines on LHRH neuronal activity, , Annals of the New York Academy of Sciences, 1993, 10.1111/j.1749-6632.1993.tb49928.x
  • Centrally injected interleukin-1 beta inhibits the hypothalamic LHRH secretion and circulating LH levels via prostaglandins in rats, , Journal of neuroendocrinology, 1993, 10.1111/j.1365-2826.1993.tb00506.x
  • The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations, , Brain pathology (Zurich, Switzerland), 1998, 10.1111/j.1750-3639.1998.tb00189.x
  • Immune Function and Regulation of the Autonomic Nervous System: A Molecular Point of View, , 2003
  • Case Report: Two Families With HPDL Related Neurodegeneration, , Frontiers in genetics, 2022, 10.3389/fgene.2022.780764
  • MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation, , Molecular psychiatry, 2008, 10.1038/sj.mp.4002122
  • Reduced Melatonin Levels May Facilitate Glioblastoma Initiation in the Subventricular Zone, , Expert reviews in molecular medicine, 2022, 10.1017/erm.2022.15
  • Immunosenescence of microglia and macrophages: impact on the ageing central nervous system, , Brain : a journal of neurology, 2016, 10.1093/brain/awv395
  • Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief, , Pain, 2014, 10.1016/j.pain.2014.01.026
  • Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta, , Cell reports, 2013, 10.1016/j.celrep.2013.10.010
  • Proinflammatory signal transduction pathways in the CNS during systemic immune response, , 2001
  • Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: a view from the blood-brain barrier, , Neuroscience, 1999, 10.1016/s0306-4522(99)00225-0
  • Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 10.1523/JNEUROSCI.2840-11.2011
  • Targeting innate immunity to protect and cure Alzheimer's disease: opportunities and pitfalls, , Molecular psychiatry, 2021, 10.1038/s41380-021-01083-4
  • Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram-negative and gram-positive bacteria, , European journal of immunology, 2003, 10.1002/eji.200323821
  • Do pathogen exposure and innate immunity cause brain diseases?, , Neurological research, 2005, 10.1179/016164105X49526
  • Inhibitory action of nitric oxide on circulating tumor necrosis factor-induced NF-kappaB activity and COX-2 transcription in the endothelium of the brain capillaries, , Journal of neuropathology and experimental neurology, 2001, 10.1093/jnen/60.9.893
  • Ovulatory cycle influences the stimulatory effect of stress on the expression of corticotropin-releasing factor receptor messenger ribonucleic acid in the paraventricular nucleus of the female rat hypothalamus, , Endocrinology, 1995, 10.1210/endo.136.9.7649116
  • The impact of Ly6Clow monocytes after cerebral hypoxia-ischemia in adult mice, , Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, 10.1038/jcbfm.2014.80
  • Interleukin-1 beta inhibits the endogenous expression of the early gene c-fos located within the nucleus of LH-RH neurons and interferes with hypothalamic LH-RH release during proestrus in the rat, , Brain research, 1993, 10.1016/0006-8993(93)90463-w
  • Microglia in Alzheimer's disease: A multifaceted relationship, , Brain, behavior, and immunity, 2016, 10.1016/j.bbi.2015.07.021
  • The neuroendocrine control of the innate immune system in health and brain diseases, , Immunological reviews, 2012, 10.1111/j.1600-065X.2012.01129.x
  • Neuroprotective effects of resident microglia following acute brain injury, , The Journal of comparative neurology, 2007, 10.1002/cne.21469
  • Delayed but not early glucocorticoid treatment protects the host during experimental herpes simplex virus encephalitis in mice, , The Journal of infectious diseases, 2007, 10.1086/511987
  • A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism, , The Journal of biological chemistry, 2004, 10.1074/jbc.M401287200
  • Lack of gestation-related changes of urocortin gene expression in human placenta, , Prenatal and neonatal medicine : the international journal of basic and clinical research and practice, 1999
  • Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis, , European journal of immunology, 2001, 10.1002/1521-4141(200111)31:113.0.co;2-j
  • Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease, , Alzheimer's research & therapy, 2021, 10.1186/s13195-020-00747-7
  • Bone marrow-derived macrophages and the CNS: An update on the use of experimental chimeric mouse models and bone marrow transplantation in neurological disorders, , Biochimica et biophysica acta, 2016, 10.1016/j.bbadis.2015.09.017
  • Immune response and brain gene expression in relation to stress, , 1999
  • Multifocal Cerebral Microinfarcts Modulate Early Alzheimer's Disease Pathology in a Sex-Dependent Manner, , Frontiers in immunology, 2021, 10.3389/fimmu.2021.813536
  • Effects of myeloablation, peripheral chimerism, and whole-body irradiation on the entry of bone marrow-derived cells into the brain, , Cell transplantation, 2012, 10.3727/096368911X593154
  • L'interleukine-6 dans le système nerveux central, , Medecine sciences : M/S, 2000
  • Cannabinoids in microglia: a new trick for immune surveillance and neuroprotection, , Neuron, 2006, 10.1016/j.neuron.2005.12.004
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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Ayanna Arneaud - Maîtrise avec mémoire - En cours
  • Lina Lapeyre - Doctorat - En cours
  • Majid Ghareghani - Post-doctorat - En cours
  • Peter Thériault - Maîtrise avec mémoire - 2014/05
  • Marc-André Bellavance - Doctorat - 2014/09
  • Jean-Philippe Michaud - Doctorat - 2015/01
  • Maude Bordeleau - Maîtrise avec mémoire - 2016/01
  • Yannick Tremblay - Maîtrise avec mémoire - 2016/09
  • Vincent Pons - Doctorat - 2020/09
  • Adham Fani Maleki - Doctorat - 2021/01
  • Pierre-Alexandre Piec - Maîtrise avec mémoire - 2022/05
  • Morgan McLaughlin - Maîtrise avec mémoire - 2022/05
  • Laura Martínez Drudis - Doctorat - 2024/09

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