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Serge Rivest

Professeur titulaire

Directeur(trice), Centre de recherche du CHU de Québec - Université Laval

Directeur(trice), Centres de recherche du CHU de Québec - UL

Serge Rivest
serge.rivest@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
Centres de recherche du CHU de Québec - UL
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Immunologie-infectiologie
Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Maladies infectieuses et immunitaires
  • Développement de vaccins
  • Immunothérapie
  • Maladies auto-immunes
  • Système immunitaire
Neurosciences, santé mentale et toxicomanies
  • Démences
  • Maladie d'Alzheimer
  • Maladies neurodégénératives
  • Maladies neuroimmunologiques
  • Sclérose en plaques
Vieillissement
  • Dégénérescence cellulaire
  • Vieillissement cellulaire

Projets de recherche

  • Chaire de recherche du Canada en neuroimmunologie - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2023-07-01 au 2030-06-30
  • Acquisition d’équipements pour les activités de recherche en oncologie de précision au Nouveau Complexe hospitalier - CHU de Québec – Université Laval – CHUL, Ministère de l'Économie et de l'Innovation - Programme de soutien aux organismes de recherche et d'innovation (PSO) - Volet 4: Soutien au financement d'infrastructures de recherche et d'innovation, chercheur principal - 2022-03-24 au 2027-03-23
  • Chercheur d'un jour - Conseil de recherches en sciences naturelles et génie Canada - PromoScience, chercheur principal - 2023-01-01 au 2025-12-31
  • Therapeutic properties of innate immune cells and system for brain diseases - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-04-01 au 2025-03-31
  • Chaire de recherche du Canada en neuroimmunologie - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2016-07-01 au 2023-06-30
  • Chercheur d'un jour - Conseil de recherches en sciences naturelles et génie Canada - PromoScience, chercheur principal - 2021-01-01 au 2022-12-31
  • Programme chercheur-e d'un jour - Fonds de recherche du Québec - Société et culture - Subventions générales de recherche et projets spéciaux (non partageable au prorata), co-chercheur - 2018-04-01 au 2021-03-31
  • Développement de marqueurs génétiques de maladies rares. - Fondation du CHU de Québec, chercheur principal - 2016-02-11 au 2020-02-10

Publications

  • Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis, , Journal of neuroimmunology, 2011, 10.1016/j.jneuroim.2011.02.005
  • Stress and interleukin-1 beta-induced activation of c-fos, NGFI-B and CRF gene expression in the hypothalamic PVN: comparison between Sprague-Dawley, Fisher-344 and Lewis rats, , Journal of neuroendocrinology, 1994, 10.1111/j.1365-2826.1994.tb00559.x
  • Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.4901-12.2013
  • Neuronal activity and neuropeptide gene transcription in the brains of immune-challenged rats, , Journal of neuroendocrinology, 1995, 10.1111/j.1365-2826.1995.tb00788.x
  • The impact of Ly6Clow monocytes after cerebral hypoxia-ischemia in adult mice, , Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, 10.1038/jcbfm.2014.80
  • Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, 10.1096/fj.04-1517fje
  • Bone marrow-derived macrophages and the CNS: An update on the use of experimental chimeric mouse models and bone marrow transplantation in neurological disorders, , Biochimica et biophysica acta, 2016, 10.1016/j.bbadis.2015.09.017
  • The role of corticotropin-releasing factor and interleukin-1 in the regulation of neurons controlling reproductive functions, , Endocrine reviews, 1995, 10.1210/edrv-16-2-177
  • Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/JNEUROSCI.3016-07.2007
  • Triggering of NOD2 Receptor Converts Inflammatory Ly6C into Ly6C Monocytes with Patrolling Properties, , Cell reports, 2017, 10.1016/j.celrep.2017.08.009
  • Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer's disease, , Journal of neuroinflammation, 2020, 10.1186/s12974-020-01893-3
  • Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
  • The LPS receptor (CD14) links innate immunity with Alzheimer's disease, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, 10.1096/fj.03-0364fje
  • Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation, , Acta neuropathologica communications, 2013, 10.1186/2051-5960-1-75
  • Involvement of serotonergic pathways in mediating the neuronal activity and genetic transcription of neuroendocrine corticotropin-releasing factor in the brain of systemically endotoxin-challenged rats, , Neuroscience, 1999, 10.1016/s0306-4522(98)00369-8
  • C-fos mRNA pattern and corticotropin-releasing factor neuronal activity throughout the brain of rats injected centrally with a prostaglandin of E2 type, , Journal of neuroimmunology, 1996, 10.1016/s0165-5728(96)00114-2
  • Tissue-Plasminogen Activator Attenuates Alzheimer's Disease-Related Pathology Development in APPswe/PS1 Mice, , Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, 10.1038/npp.2015.279
  • Stress-induced genetic expression of a selective corticotropin-releasing factor-receptor subtype within the rat ovaries: an effect dependent on the ovulatory cycle, , Biology of reproduction, 1995, 10.1095/biolreprod53.6.1417
  • The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease, , The European journal of neuroscience, 2012, 10.1111/j.1460-9568.2012.08126.x
  • Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease, , Genes, brain, and behavior, 2009, 10.1111/j.1601-183X.2008.00453.x
  • Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta, , Journal of neurochemistry, 1997, 10.1046/j.1471-4159.1997.69041668.x
  • C-C chemokine receptor type 2 (CCR2) signaling protects neonatal male mice with hypoxic-ischemic hippocampal damage from developing spatial learning deficits, , Behavioural brain research, 2015, 10.1016/j.bbr.2015.02.053
  • Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta, , Cell reports, 2013, 10.1016/j.celrep.2013.10.010
  • Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice, , Frontiers in cellular neuroscience, 2012, 10.3389/fncel.2012.00051
  • Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/JNEUROSCI.3027-07.2007
  • Differential effects of central and peripheral injection of interleukin-1 beta on brain c-fos expression and neuroendocrine functions, , Brain research, 1992, 10.1016/0006-8993(92)91424-d
  • Role of inflammation in the neurobiology of stem cells, , Neuroreport, 2004, 10.1097/00001756-200410250-00001
  • Effect of immobilization stress on transcriptional activity of inducible immediate-early genes, corticotropin-releasing factor, its type 1 receptor, and enkephalin in the hypothalamus of borderline hypertensive rats, , Journal of neurochemistry, 1998, 10.1046/j.1471-4159.1998.70041556.x
  • Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology, , Neuron, 2015, 10.1016/j.neuron.2015.01.021
  • mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis, , Frontiers in cellular neuroscience, 2018, 10.3389/fncel.2018.00178
  • Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 10.1523/JNEUROSCI.4786-03.2004
  • Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury, , Journal of neurochemistry, 2007, 10.1111/j.1471-4159.2007.04524.x
  • Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease, , Brain : a journal of neurology, 2009, 10.1093/brain/awn331
  • Luteinizing hormone secretion and corticotropin-releasing factor gene expression in the paraventricular nucleus of rhesus monkeys following cortisol synthesis inhibition, , Endocrinology, 1997, 10.1210/endo.138.6.5171
  • Effects of myeloablation, peripheral chimerism, and whole-body irradiation on the entry of bone marrow-derived cells into the brain, , Cell transplantation, 2012, 10.3727/096368911X593154
  • Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology, , Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1215165110
  • Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14, , Journal of immunology (Baltimore, Md. : 1950), 2002, 10.4049/jimmunol.169.6.3370
  • Triggering Innate Immune Receptors as New Therapies in Alzheimer's Disease and Multiple Sclerosis, , Cells, 2021, 10.3390/cells10082164
  • Microglia Ontology and Signaling, , Frontiers in cell and developmental biology, 2016, 10.3389/fcell.2016.00072
  • Perspective: how to make microarray, serial analysis of gene expression, and proteomic relevant to day-to-day endocrine problems and physiological systems, , Endocrinology, 2002, 10.1210/endo.143.6.8868
  • Immune System–Neuroendocrine Interactions, , 2009
  • Modulation of the innate immune response by NMDA receptors has neuropathological consequences, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
  • Immune response and brain gene expression in relation to stress, , 1999
  • The complement system is an integrated part of the natural innate immune response in the brain, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, 10.1096/fj.00-0709fje
  • Neuronal activation of the hypothalamic magnocellular system in response to oropharyngeal stimuli in the rat, , Journal of neuroendocrinology, 1997, 10.1046/j.1365-2826.1997.00573.x
  • PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system, , Life science alliance, 2022, 10.26508/lsa.202201467
  • Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor kappaB alpha within specific cellular populations of the rat brain, , Journal of neurochemistry, 1999, 10.1046/j.1471-4159.1999.0730309.x
  • IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults, , Frontiers in cellular neuroscience, 2013, 10.3389/fncel.2013.00009
  • Arachidonate Metabolites in the Neurophysiological System: The Fever Pathway, , 2004
  • Reduced Melatonin Levels May Facilitate Glioblastoma Initiation in the Subventricular Zone, , Expert reviews in molecular medicine, 2022, 10.1017/erm.2022.15
  • Context-dependent transcriptional regulation of microglial proliferation, , Glia, 2022, 10.1002/glia.24124
  • Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration, , The Journal of comparative neurology, 2013, 10.1002/cne.23363
  • A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease, , Journal of molecular cell biology, 2013, 10.1093/jmcb/mjt028
  • The HPA - Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain, , Frontiers in immunology, 2014, 10.3389/fimmu.2014.00136
  • Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.0535-13.2013
  • Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease, , Neuropharmacology, 2011, 10.1016/j.neuropharm.2011.01.035
  • GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease, , Brain, behavior, and immunity, 2015, 10.1016/j.bbi.2015.01.010
  • Tissue specificity of SNS response to exercise in mice exposed to low temperatures, , The American journal of physiology, 1992, 10.1152/ajpregu.1992.262.5.R921
  • Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains, , Infection and immunity, 2002, 10.1128/IAI.70.4.1997-2009.2002
  • Role of the chemokine receptors CCR2 and CX3CR1 in an experimental model of thrombotic stroke, , Brain, behavior, and immunity, 2018, 10.1016/j.bbi.2018.03.008
  • Neuroprotective role of the innate immune system by microglia, , Neuroscience, 2007, 10.1016/j.neuroscience.2007.02.055
  • Innate immunity in the CNS: redefining the relationship between the CNS and Its environment, , Neuron, 2013, 10.1016/j.neuron.2013.04.005
  • The dynamics of monocytes and microglia in Alzheimer's disease, , Alzheimer's research & therapy, 2015, 10.1186/s13195-015-0125-2
  • Interactions between the immune and neuroendocrine systems, , Progress in brain research, 2010, 10.1016/S0079-6123(08)81004-7
  • Molecular insights on the cerebral innate immune system, , Brain, behavior, and immunity, 2003, 10.1016/s0889-1591(02)00055-7
  • Regulation of corticotropin-releasing factor type 1 (CRF1) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF, , Endocrinology, 1996, 10.1210/endo.137.11.8895325
  • Cannabinoids in microglia: a new trick for immune surveillance and neuroprotection, , Neuron, 2006, 10.1016/j.neuron.2005.12.004
  • Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain, , Journal of innate immunity, 2009, 10.1159/000225990
  • Activation of the nuclear factor kappa B (NF-kappaB) and cyclooxygenase-2 (COX-2) genes in cerebral blood vessels in response to systemic inflammation, , Molecular psychiatry, 1999
  • Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice, , Neurobiology of aging, 2013, 10.1016/j.neurobiolaging.2012.06.025
  • Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain, , The European journal of neuroscience, 2002, 10.1046/j.1460-9568.2002.02057.x
  • Do pathogen exposure and innate immunity cause brain diseases?, , Neurological research, 2005, 10.1179/016164105X49526
  • Interleukin-1 and luteinizing hormone-releasing hormone system: a powerful interaction within the brain still lacking of anatomical and physiological links, , 1997
  • Immunosenescence of microglia and macrophages: impact on the ageing central nervous system, , Brain : a journal of neurology, 2016, 10.1093/brain/awv395
  • Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxicity in the mouse brain, , Journal of immunology (Baltimore, Md. : 1950), 2004, 10.4049/jimmunol.172.11.7043
  • The combination of valacyclovir with an anti-TNF alpha antibody increases survival rate compared to antiviral therapy alone in a murine model of herpes simplex virus encephalitis, , Antiviral research, 2013, 10.1016/j.antiviral.2013.10.007
  • L'interleukine-6 dans le système nerveux central, , Medecine sciences : M/S, 2000
  • Effect of exercise training on energy balance of orchidectomized rats, , The American journal of physiology, 1989, 10.1152/ajpregu.1989.257.3.R550
  • Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis, , The Journal of infectious diseases, 2008, 10.1086/590671
  • An Early Microglial Response Is Needed To Efficiently Control Herpes Simplex Virus Encephalitis, , Journal of virology, 2020, 10.1128/JVI.01428-20
  • Lesions of hypothalamic PVN partially attenuate stimulatory action of alcohol on ACTH secretion in rats, , The American journal of physiology, 1994, 10.1152/ajpregu.1994.266.2.R553
  • Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge, , Journal of neuropathology and experimental neurology, 1999, 10.1097/00005072-199901000-00008
  • Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis, , Behavioural brain research, 2011, 10.1016/j.bbr.2011.07.034
  • Role of Macrophage Colony-Stimulating Factor Receptor on the Proliferation and Survival of Microglia Following Systemic Nerve and Cuprizone-Induced Injuries, , Frontiers in immunology, 2020, 10.3389/fimmu.2020.00047
  • Selective involvement of interleukin-6 in the transcriptional activation of the suppressor of cytokine signaling-3 in the brain during systemic immune challenges, , Endocrinology, 2000, 10.1210/endo.141.10.7695
  • The 5-hydroxytryptamine agonist fenfluramine increases Fos-like immunoreactivity in the brain, , Brain research, 1992, 10.1016/0006-8993(92)91037-f
  • An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999
  • Hypothalamic paraventricular nucleus lesions do not prevent anorectic effect of exercise in male rats, , The American journal of physiology, 1990, 10.1152/ajpregu.1990.259.3.R579
  • Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity, , Brain structure & function, 2015, 10.1007/s00429-014-0759-z
  • Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide, , Journal of neurochemistry, 2001, 10.1046/j.1471-4159.2001.00080.x
  • Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS, , Journal of neurochemistry, 2001, 10.1046/j.1471-4159.2001.00603.x
  • Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression, , Brain, behavior, and immunity, 2022, 10.1016/j.bbi.2021.07.016
  • Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease, , Pharmacological reviews, 2022, 10.1124/pharmrev.121.000400
  • Sub-acute systemic erythropoietin administration reduces ischemic brain injury in an age-dependent manner, , Oncotarget, 2016, 10.18632/oncotarget.9652
  • Hematopoietic MyD88-adaptor protein acts as a natural defense mechanism for cognitive deficits in Alzheimer's disease, , Stem cell reviews and reports, 2012, 10.1007/s12015-012-9356-9
  • Corticotropin-releasing factor (CRF) and stress-related reproductive failure: the brain as a state of the art or the ovary as a novel clue?, , Journal of endocrinological investigation, 1995, 10.1007/BF03349836
  • CX3CR1 in multiple sclerosis, , Oncotarget, 2015, 10.18632/oncotarget.4650
  • Is survival possible without arachidonate metabolites in the brain during systemic infection?, , News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society, 2003, 10.1152/nips.01415.2002
  • The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS, , Brain pathology (Zurich, Switzerland), 2002, 10.1111/j.1750-3639.2002.tb00445.x
  • A 'don't eat me' immune signal protects neuronal connections, , Nature, 2018, 10.1038/d41586-018-07165-8
  • Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke, , Nature medicine, 2009, 10.1038/nm.1927
  • Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain, , Journal of neurochemistry, 1998, 10.1046/j.1471-4159.1998.70020452.x
  • MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1, , The Journal of biological chemistry, 2009, 10.1074/jbc.M807530200
  • Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation, , The European journal of neuroscience, 1999, 10.1046/j.1460-9568.1999.00682.x
  • Microglia in Alzheimer's disease: A multifaceted relationship, , Brain, behavior, and immunity, 2016, 10.1016/j.bbi.2015.07.021
  • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease, , Neuron, 2006, 10.1016/j.neuron.2006.01.022
  • Interleukin-1 beta inhibits the endogenous expression of the early gene c-fos located within the nucleus of LH-RH neurons and interferes with hypothalamic LH-RH release during proestrus in the rat, , Brain research, 1993, 10.1016/0006-8993(93)90463-w
  • Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
  • Case Report: Two Families With HPDL Related Neurodegeneration, , Frontiers in genetics, 2022, 10.3389/fgene.2022.780764
  • A founder mutation in the gene in families from Saguenay-Lac-St-Jean region affected by a pyridoxine-dependent epilepsy, , JIMD reports, 2021, 10.1002/jmd2.12196
  • Cloning of murine TReP-132, a novel transcription factor expressed in brain regions involved in behavioral and psychiatric disorders, , Molecular psychiatry, 2003, 10.1038/sj.mp.4001201
  • Effect of immune and metabolic challenges on the luteinizing hormone-releasing hormone neuronal system in cycling female rats: an evaluation at the transcriptional level, , Endocrinology, 1997, 10.1210/endo.138.4.5044
  • Lack of gestation-related changes of urocortin gene expression in human placenta, , Prenatal and neonatal medicine : the international journal of basic and clinical research and practice, 1999
  • A functional analysis of EP4 receptor-expressing neurons in mediating the action of prostaglandin E2 within specific nuclei of the brain in response to circulating interleukin-1beta, , Journal of neurochemistry, 2000, 10.1046/j.1471-4159.2000.0742134.x
  • Effect of dexfenfluramine on the transcriptional activation of CRF and its type 1 receptor within the paraventricular nucleus of the rat hypothalamus, , British journal of pharmacology, 1996, 10.1111/j.1476-5381.1996.tb16692.x
  • A Homozygous Deep Intronic Mutation Alters the Splicing of Nebulin Gene in a Patient With Nemaline Myopathy, , Frontiers in neurology, 2021, 10.3389/fneur.2021.660113
  • Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, 10.1007/s13311-020-00998-0
  • Functional circuitry in the brain of immune-challenged rats: partial involvement of prostaglandins, , The Journal of comparative neurology, 1997, 10.1002/(sici)1096-9861(19971020)387:23.0.co;2-r
  • Immune receptors involved in Streptococcus suis recognition by dendritic cells, , PloS one, 2012, 10.1371/journal.pone.0044746
  • Inflammatory Monocytes and Neutrophils Regulate Streptococcus suis-Induced Systemic Inflammation and Disease but Are Not Critical for the Development of Central Nervous System Disease in a Mouse Model of Infection, , Infection and immunity, 2020, 10.1128/IAI.00787-19
  • Mechanisms mediating the effects of cytokines on neuroendocrine functions in the rat, , Ciba Foundation symposium, 1993, 10.1002/9780470514368.ch10
  • Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 10.1523/JNEUROSCI.1642-11.2011
  • Microglia Purinoceptor P2Y6: An Emerging Therapeutic Target in CNS Diseases, , Cells, 2020, 10.3390/cells9071595
  • Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain, , The American journal of physiology, 1998, 10.1152/ajpregu.1998.275.5.R1438
  • The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease, , Frontiers in physiology, 2013, 10.3389/fphys.2013.00045
  • Microglia: Senescence Impairs Clearance of Myelin Debris, , Current biology : CB, 2016, 10.1016/j.cub.2016.06.066
  • The role of microglial cell subsets in Alzheimer's disease, , Current Alzheimer research, 2011, 10.2174/156720511795256035
  • Bone marrow stem cells to the rescue of Alzheimer's disease, , Medecine sciences : M/S, 2006, 10.1051/medsci/20062210822
  • Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors, , Endocrine reviews, 2012, 10.1210/er.2011-1049
  • Central mechanisms and sites of action involved in the inhibitory effects of CRF and cytokines on LHRH neuronal activity, , Annals of the New York Academy of Sciences, 1993, 10.1111/j.1749-6632.1993.tb49928.x
  • Neuroprotective effects of resident microglia following acute brain injury, , The Journal of comparative neurology, 2007, 10.1002/cne.21469
  • Comparison of the susceptibilities of C57BL/6 and A/J mouse strains to Streptococcus suis serotype 2 infection, , Infection and immunity, 2008, 10.1128/IAI.00350-08
  • Glucocorticoids play a fundamental role in protecting the brain during innate immune response, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
  • Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 10.1523/JNEUROSCI.2840-11.2011
  • New Therapeutic Avenues of mCSF for Brain Diseases and Injuries, , Frontiers in cellular neuroscience, 2018, 10.3389/fncel.2018.00499
  • Effects of corticotropin-releasing factor on energy balance in rats are sex dependent, , The American journal of physiology, 1989, 10.1152/ajpregu.1989.257.6.R1417
  • Regulation of innate immune responses in the brain, , Nature reviews. Immunology, 2009, 10.1038/nri2565
  • Influence of cytokines on neuroendocrine functions during immune response. Mechanisms involved and neuronal pathways, , Annales d'endocrinologie, 1995
  • Reduced corticotropin-releasing factor and enhanced vasopressin gene expression in brains of mice with autoimmunity-induced behavioral dysfunction, , Journal of neuroimmunology, 1999, 10.1016/s0165-5728(99)00021-1
  • Stimulation of monocytes, macrophages, and microglia by amphotericin B and macrophage colony-stimulating factor promotes remyelination, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, 10.1523/JNEUROSCI.1797-14.2015
  • A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1, , Immunity, 2009, 10.1016/j.immuni.2009.03.020
  • Role of cyclo-oxygenase pathways in the stimulatory influence of immune challenge on the transcription of a specific CRF receptor subtype in the rat brain, , Journal of chemical neuroanatomy, 1996, 10.1016/0891-0618(95)00106-9
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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Lina Lapeyre - Doctorat - En cours
  • Majid Ghareghani - Post-doctorat - En cours
  • Ayanna Arneaud - Maîtrise avec mémoire - En cours
  • Peter Thériault - Maîtrise avec mémoire - 2014/05
  • Marc-André Bellavance - Doctorat - 2014/09
  • Jean-Philippe Michaud - Doctorat - 2015/01
  • Maude Bordeleau - Maîtrise avec mémoire - 2016/01
  • Yannick Tremblay - Maîtrise avec mémoire - 2016/09
  • Vincent Pons - Doctorat - 2020/09
  • Adham Fani Maleki - Doctorat - 2021/01
  • Morgan McLaughlin - Maîtrise avec mémoire - 2022/05
  • Pierre-Alexandre Piec - Maîtrise avec mémoire - 2022/05
  • Laura Martínez Drudis - Doctorat - 2024/09

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  • Médecine moléculaire

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