Découvrez nos professeurs et professeures!
Serge Rivest
Professeur titulaire
Directeur(trice), Centre de recherche du CHU de Québec - Université Laval
Directeur(trice), Centres de recherche du CHU de Québec - UL
![Serge Rivest](https://api.professeur.fmed.ulaval.ca/image/chercheurs/Rivest_Serge3.jpg)
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de médecine :
Bioinformatique / données massives (big data)
Immunologie-infectiologie
Neurosciences et santé mentale
Domaines et intérêts de recherche du (de la) professeur(e) :
Maladies infectieuses et immunitaires
- Développement de vaccins
- Immunothérapie
- Maladies auto-immunes
- Système immunitaire
Neurosciences, santé mentale et toxicomanies
- Démences
- Maladie d'Alzheimer
- Maladies neurodégénératives
- Maladies neuroimmunologiques
- Sclérose en plaques
Vieillissement
- Dégénérescence cellulaire
- Vieillissement cellulaire
Projets de recherche
- Chaire de recherche du Canada en neuroimmunologie - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2023-07-01 au 2030-06-30
- Acquisition d’équipements pour les activités de recherche en oncologie de précision au Nouveau Complexe hospitalier - CHU de Québec – Université Laval – CHUL, Ministère de l'Économie et de l'Innovation - Programme de soutien aux organismes de recherche et d'innovation (PSO) - Volet 4: Soutien au financement d'infrastructures de recherche et d'innovation, chercheur principal - 2022-03-24 au 2027-03-23
- Chercheur d'un jour - Conseil de recherches en sciences naturelles et génie Canada - PromoScience, chercheur principal - 2023-01-01 au 2025-12-31
- Therapeutic properties of innate immune cells and system for brain diseases - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-04-01 au 2025-03-31
- Chaire de recherche du Canada en neuroimmunologie - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2016-07-01 au 2023-06-30
- Chercheur d'un jour - Conseil de recherches en sciences naturelles et génie Canada - PromoScience, chercheur principal - 2021-01-01 au 2022-12-31
- Programme chercheur-e d'un jour - Fonds de recherche du Québec - Société et culture - Subventions générales de recherche et projets spéciaux (non partageable au prorata), co-chercheur - 2018-04-01 au 2021-03-31
- Développement de marqueurs génétiques de maladies rares. - Fondation du CHU de Québec, chercheur principal - 2016-02-11 au 2020-02-10
Publications
- Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei, , Journal of neuroscience research, 1999
- Glucocorticoids: protectors of the brain during innate immune responses, , The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2004, 10.1177/1073858404263494
- Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, 10.1096/fj.04-1517fje
- QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis, , Cell reports, 2020, 10.1016/j.celrep.2020.108560
- Influence of the estrous cycle on c-fos and CRH gene transcription in the brain of endotoxin-challenged female rats, , Neuroendocrinology, 1997, 10.1159/000127162
- A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease, , Journal of molecular cell biology, 2013, 10.1093/jmcb/mjt028
- Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor, , Journal of immunology (Baltimore, Md. : 1950), 2000, 10.4049/jimmunol.165.4.2232
- Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain, , The European journal of neuroscience, 2002, 10.1046/j.1460-9568.2002.02057.x
- Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli, , Journal of neurochemistry, 2005, 10.1111/j.1471-4159.2005.03480.x
- Effects of corticotropin-releasing factor on energy balance in rats are sex dependent, , The American journal of physiology, 1989, 10.1152/ajpregu.1989.257.6.R1417
- Ovulatory cycle influences the stimulatory effect of stress on the expression of corticotropin-releasing factor receptor messenger ribonucleic acid in the paraventricular nucleus of the female rat hypothalamus, , Endocrinology, 1995, 10.1210/endo.136.9.7649116
- Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, 10.1523/JNEUROSCI.4937-05.2006
- Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief, , Pain, 2014, 10.1016/j.pain.2014.01.026
- Inefficient clearance of myelin debris by microglia impairs remyelinating processes, , The Journal of experimental medicine, 2015, 10.1084/jem.20141656
- PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis, , Frontiers in immunology, 2022, 10.3389/fimmu.2022.862316
- Centrally injected interleukin-1 beta inhibits the hypothalamic LHRH secretion and circulating LH levels via prostaglandins in rats, , Journal of neuroendocrinology, 1993, 10.1111/j.1365-2826.1993.tb00506.x
- Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis, , The Journal of infectious diseases, 2007, 10.1086/520094
- The HPA - Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain, , Frontiers in immunology, 2014, 10.3389/fimmu.2014.00136
- Role of adaptor protein MyD88 in TLR-mediated preconditioning and neuroprotection after acute excitotoxicity, , Brain, behavior, and immunity, 2015, 10.1016/j.bbi.2015.02.019
- Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer's disease, , Journal of neuroinflammation, 2020, 10.1186/s12974-020-01893-3
- Case Report: Two Families With HPDL Related Neurodegeneration, , Frontiers in genetics, 2022, 10.3389/fgene.2022.780764
- Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease, , Neuropharmacology, 2011, 10.1016/j.neuropharm.2011.01.035
- The role of corticotropin-releasing factor and interleukin-1 in the regulation of neurons controlling reproductive functions, , Endocrine reviews, 1995, 10.1210/edrv-16-2-177
- Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer's Disease and Multiple Sclerosis, , Frontiers in cellular neuroscience, 2019, 10.3389/fncel.2019.00355
- MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation, , Molecular psychiatry, 2008, 10.1038/sj.mp.4002122
- Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice, , Neurobiology of aging, 2013, 10.1016/j.neurobiolaging.2012.06.025
- A functional analysis of EP4 receptor-expressing neurons in mediating the action of prostaglandin E2 within specific nuclei of the brain in response to circulating interleukin-1beta, , Journal of neurochemistry, 2000, 10.1046/j.1471-4159.2000.0742134.x
- MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease, , Molecular neurodegeneration, 2011, 10.1186/1750-1326-6-5
- Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression, , Brain, behavior, and immunity, 2022, 10.1016/j.bbi.2021.07.016
- Differential effects of central and peripheral injection of interleukin-1 beta on brain c-fos expression and neuroendocrine functions, , Brain research, 1992, 10.1016/0006-8993(92)91424-d
- Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/JNEUROSCI.4901-12.2013
- Modulation of the innate immune response by NMDA receptors has neuropathological consequences, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
- Stimulation of monocytes, macrophages, and microglia by amphotericin B and macrophage colony-stimulating factor promotes remyelination, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, 10.1523/JNEUROSCI.1797-14.2015
- Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease, , Molecular psychiatry, 2006, 10.1038/sj.mp.4001809
- Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1, , European journal of immunology, 2005, 10.1002/eji.200526037
- The combination of valacyclovir with an anti-TNF alpha antibody increases survival rate compared to antiviral therapy alone in a murine model of herpes simplex virus encephalitis, , Antiviral research, 2013, 10.1016/j.antiviral.2013.10.007
- Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity, , Brain structure & function, 2015, 10.1007/s00429-014-0759-z
- CRF alters the infundibular LHRH secretory system from the medial preoptic area of female rats: possible involvement of opioid receptors, , Neuroendocrinology, 1993, 10.1159/000126365
- Role of the innate immune response in the brain, , Medecine sciences : M/S, 2003, 10.1051/medsci/20031910981
- Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors, , Endocrine reviews, 2012, 10.1210/er.2011-1049
- Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta, , Cell reports, 2013, 10.1016/j.celrep.2013.10.010
- Mechanisms mediating the effects of cytokines on neuroendocrine functions in the rat, , Ciba Foundation symposium, 1993, 10.1002/9780470514368.ch10
- Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy, , Neurobiology of disease, 2004, 10.1016/j.nbd.2004.03.010
- Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice, , Oncotarget, 2016, 10.18632/oncotarget.7689
- Regulation of innate immune responses in the brain, , Nature reviews. Immunology, 2009, 10.1038/nri2565
- Bone marrow-derived macrophages and the CNS: An update on the use of experimental chimeric mouse models and bone marrow transplantation in neurological disorders, , Biochimica et biophysica acta, 2016, 10.1016/j.bbadis.2015.09.017
- Corticotropin-releasing factor and glucocorticoid receptor (GR) gene expression in the paraventricular nucleus of immune-challenged transgenic mice expressing type II GR antisense ribonucleic acid, , Journal of molecular neuroscience : MN, 1997, 10.1007/BF02736831
- Expression of corticotropin-releasing factor and its receptors in the brain of lean and obese Zucker rats, , Endocrinology, 1996, 10.1210/endo.137.11.8895348
- Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
- Immune System–Neuroendocrine Interactions, , 2009
- Is survival possible without arachidonate metabolites in the brain during systemic infection?, , News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society, 2003, 10.1152/nips.01415.2002
- Central mechanisms and sites of action involved in the inhibitory effects of CRF and cytokines on LHRH neuronal activity, , Annals of the New York Academy of Sciences, 1993, 10.1111/j.1749-6632.1993.tb49928.x
- Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain, , Journal of neurochemistry, 1998, 10.1046/j.1471-4159.1998.70020452.x
- Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge, , Journal of neuropathology and experimental neurology, 1999, 10.1097/00005072-199901000-00008
- Role of inflammation in the neurobiology of stem cells, , Neuroreport, 2004, 10.1097/00001756-200410250-00001
- Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/JNEUROSCI.3027-07.2007
- Selective involvement of interleukin-6 in the transcriptional activation of the suppressor of cytokine signaling-3 in the brain during systemic immune challenges, , Endocrinology, 2000, 10.1210/endo.141.10.7695
- Effect of exercise training on energy balance of orchidectomized rats, , The American journal of physiology, 1989, 10.1152/ajpregu.1989.257.3.R550
- Neuronal activity and neuropeptide gene transcription in the brains of immune-challenged rats, , Journal of neuroendocrinology, 1995, 10.1111/j.1365-2826.1995.tb00788.x
- A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600, , The Journal of biological chemistry, 2013, 10.1074/jbc.M113.483107
- Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, 10.1523/JNEUROSCI.4032-05.2006
- MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1, , The Journal of biological chemistry, 2009, 10.1074/jbc.M807530200
- The promise of anti-inflammatory therapies for CNS injuries and diseases, , Expert review of neurotherapeutics, 2011, 10.1586/ern.11.64
- Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke, , Nature medicine, 2009, 10.1038/nm.1927
- Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration, , The Journal of comparative neurology, 2013, 10.1002/cne.23363
- Molecular insights on the cerebral innate immune system, , Brain, behavior, and immunity, 2003, 10.1016/s0889-1591(02)00055-7
- Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation, , The European journal of neuroscience, 1999, 10.1046/j.1460-9568.1999.00682.x
- Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis, , European journal of immunology, 2001, 10.1002/1521-4141(200111)31:113.0.co;2-j
- Immunosenescence of microglia and macrophages: impact on the ageing central nervous system, , Brain : a journal of neurology, 2016, 10.1093/brain/awv395
- Innate immunity: the missing link in neuroprotection and neurodegeneration?, , Nature reviews. Neuroscience, 2002, 10.1038/nrn752
- Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease, , Pharmacological reviews, 2022, 10.1124/pharmrev.121.000400
- In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain, , Endocrinology, 2002, 10.1210/en.2002-220598
- Corticotropin-releasing factor (CRF) and stress-related reproductive failure: the brain as a state of the art or the ovary as a novel clue?, , Journal of endocrinological investigation, 1995, 10.1007/BF03349836
- PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system, , Life science alliance, 2022, 10.26508/lsa.202201467
- Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration, , Annals of neurology, 2001, 10.1002/ana.1256
- The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease, , The European journal of neuroscience, 2012, 10.1111/j.1460-9568.2012.08126.x
- Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease, , Neuron, 2006, 10.1016/j.neuron.2006.01.022
- Multifocal Cerebral Microinfarcts Modulate Early Alzheimer's Disease Pathology in a Sex-Dependent Manner, , Frontiers in immunology, 2021, 10.3389/fimmu.2021.813536
- Immunotherapy for neurological diseases, , Clinical immunology (Orlando, Fla.), 2008, 10.1016/j.clim.2008.04.003
- An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003
- The role of pericytes in neurovascular unit remodeling in brain disorders, , International journal of molecular sciences, 2014, 10.3390/ijms15046453
- MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis, , The Journal of cell biology, 2007, 10.1083/jcb.200705046
- A 'don't eat me' immune signal protects neuronal connections, , Nature, 2018, 10.1038/d41586-018-07165-8
- Inflammatory Monocytes and Neutrophils Regulate Streptococcus suis-Induced Systemic Inflammation and Disease but Are Not Critical for the Development of Central Nervous System Disease in a Mouse Model of Infection, , Infection and immunity, 2020, 10.1128/IAI.00787-19
- Effect of immune and metabolic challenges on the luteinizing hormone-releasing hormone neuronal system in cycling female rats: an evaluation at the transcriptional level, , Endocrinology, 1997, 10.1210/endo.138.4.5044
- Tissue-Plasminogen Activator Attenuates Alzheimer's Disease-Related Pathology Development in APPswe/PS1 Mice, , Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, 10.1038/npp.2015.279
- Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination, , Annals of neurology, 2012, 10.1002/ana.23599
- Innate immunity in the CNS: redefining the relationship between the CNS and Its environment, , Neuron, 2013, 10.1016/j.neuron.2013.04.005
- Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system, , Brain, behavior, and immunity, 2007, 10.1016/j.bbi.2006.12.004
- Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta, , Journal of neurochemistry, 1997, 10.1046/j.1471-4159.1997.69041668.x
- Lack of gestation-related changes of urocortin gene expression in human placenta, , Prenatal and neonatal medicine : the international journal of basic and clinical research and practice, 1999
- Interleukin-1 beta inhibits the endogenous expression of the early gene c-fos located within the nucleus of LH-RH neurons and interferes with hypothalamic LH-RH release during proestrus in the rat, , Brain research, 1993, 10.1016/0006-8993(93)90463-w
- The role of exercise in thermogenesis and energy balance, , Canadian journal of physiology and pharmacology, 1989, 10.1139/y89-064
- Triggering Innate Immune Receptors as New Therapies in Alzheimer's Disease and Multiple Sclerosis, , Cells, 2021, 10.3390/cells10082164
- Arachidonate Metabolites in the Neurophysiological System: The Fever Pathway, , 2004
- Stress-induced genetic expression of a selective corticotropin-releasing factor-receptor subtype within the rat ovaries: an effect dependent on the ovulatory cycle, , Biology of reproduction, 1995, 10.1095/biolreprod53.6.1417
- Fluoxetine induces the transcription of genes encoding c-fos, corticotropin-releasing factor and its type 1 receptor in rat brain, , Neuroscience, 1998, 10.1016/s0306-4522(98)00147-x
- Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis, , Journal of neuroimmunology, 2005, 10.1016/j.jneuroim.2005.06.016
- A Homozygous Deep Intronic Mutation Alters the Splicing of Nebulin Gene in a Patient With Nemaline Myopathy, , Frontiers in neurology, 2021, 10.3389/fneur.2021.660113
- New Therapeutic Avenues of mCSF for Brain Diseases and Injuries, , Frontiers in cellular neuroscience, 2018, 10.3389/fncel.2018.00499
- Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease, , Physiology & behavior, 2011, 10.1016/j.physbeh.2011.05.023
- Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14, , Journal of immunology (Baltimore, Md. : 1950), 2002, 10.4049/jimmunol.169.6.3370
- A founder mutation in the gene in families from Saguenay-Lac-St-Jean region affected by a pyridoxine-dependent epilepsy, , JIMD reports, 2021, 10.1002/jmd2.12196
- Cloning of murine TReP-132, a novel transcription factor expressed in brain regions involved in behavioral and psychiatric disorders, , Molecular psychiatry, 2003, 10.1038/sj.mp.4001201
- Microglia Purinoceptor P2Y6: An Emerging Therapeutic Target in CNS Diseases, , Cells, 2020, 10.3390/cells9071595
- TREM2 enables amyloid β clearance by microglia, , Cell research, 2015, 10.1038/cr.2015.37
- Microglia: Senescence Impairs Clearance of Myelin Debris, , Current biology : CB, 2016, 10.1016/j.cub.2016.06.066
- Alcohol-induced inhibition of LH secretion in intact and gonadectomized male and female rats: possible mechanisms, , Alcoholism, clinical and experimental research, 1992, 10.1111/j.1530-0277.1992.tb01896.x
- Lesions of hypothalamic PVN partially attenuate stimulatory action of alcohol on ACTH secretion in rats, , The American journal of physiology, 1994, 10.1152/ajpregu.1994.266.2.R553
- Effect of stress on the activity of the hypothalamic-pituitary-gonadal axis: peripheral and central mechanisms, , Biology of reproduction, 1991, 10.1095/biolreprod45.4.523
- Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, 10.1096/fj.00-0339com
- Corticotropin-releasing hormone and its receptors; an evaluation at the transcription level in vivo, , Peptides, 2001, 10.1016/s0196-9781(01)00389-8
- Involvement of serotonergic pathways in mediating the neuronal activity and genetic transcription of neuroendocrine corticotropin-releasing factor in the brain of systemically endotoxin-challenged rats, , Neuroscience, 1999, 10.1016/s0306-4522(98)00369-8
- Tissue specificity of SNS response to exercise in mice exposed to low temperatures, , The American journal of physiology, 1992, 10.1152/ajpregu.1992.262.5.R921
- Effects of exercise on energy balance in meal-fed mice, , Physiology & behavior, 1991, 10.1016/0031-9384(91)90043-n
- Role of Macrophage Colony-Stimulating Factor Receptor on the Proliferation and Survival of Microglia Following Systemic Nerve and Cuprizone-Induced Injuries, , Frontiers in immunology, 2020, 10.3389/fimmu.2020.00047
- Do pathogen exposure and innate immunity cause brain diseases?, , Neurological research, 2005, 10.1179/016164105X49526
- Correction to: Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, 10.1007/s13311-021-01035-4
- Innate immune receptor expression in normal brain aging, , Neuroscience, 2007, 10.1016/j.neuroscience.2007.01.004
- Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease, , Molecular medicine (Cambridge, Mass.), 2012, 10.2119/molmed.2011.00306
- The role of microglial cell subsets in Alzheimer's disease, , Current Alzheimer research, 2011, 10.2174/156720511795256035
- The dynamics of monocytes and microglia in Alzheimer's disease, , Alzheimer's research & therapy, 2015, 10.1186/s13195-015-0125-2
- The hematopoietic cytokine M-CSF as a cure for Alzheimer's disease, , Medecine sciences : M/S, 2009, 10.1051/medsci/2009258-9666
- Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain, , Journal of innate immunity, 2009, 10.1159/000225990
- CX3CR1 in multiple sclerosis, , Oncotarget, 2015, 10.18632/oncotarget.4650
- Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice, , Frontiers in cellular neuroscience, 2012, 10.3389/fncel.2012.00051
- Luteinizing hormone secretion and corticotropin-releasing factor gene expression in the paraventricular nucleus of rhesus monkeys following cortisol synthesis inhibition, , Endocrinology, 1997, 10.1210/endo.138.6.5171
- Taking advantage of the systemic immune system to cure brain diseases, , Neuron, 2009, 10.1016/j.neuron.2009.09.035
- Stress and interleukin-1 beta-induced activation of c-fos, NGFI-B and CRF gene expression in the hypothalamic PVN: comparison between Sprague-Dawley, Fisher-344 and Lewis rats, , Journal of neuroendocrinology, 1994, 10.1111/j.1365-2826.1994.tb00559.x
- Inhibitory action of nitric oxide on circulating tumor necrosis factor-induced NF-kappaB activity and COX-2 transcription in the endothelium of the brain capillaries, , Journal of neuropathology and experimental neurology, 2001, 10.1093/jnen/60.9.893
- Sub-acute systemic erythropoietin administration reduces ischemic brain injury in an age-dependent manner, , Oncotarget, 2016, 10.18632/oncotarget.9652
- Perspective: how to make microarray, serial analysis of gene expression, and proteomic relevant to day-to-day endocrine problems and physiological systems, , Endocrinology, 2002, 10.1210/endo.143.6.8868
- Microglia, , Current biology : CB, 2008, 10.1016/j.cub.2008.04.047
- Role of cyclo-oxygenase pathways in the stimulatory influence of immune challenge on the transcription of a specific CRF receptor subtype in the rat brain, , Journal of chemical neuroanatomy, 1996, 10.1016/0891-0618(95)00106-9
- C-C chemokine receptor type 2 (CCR2) signaling protects neonatal male mice with hypoxic-ischemic hippocampal damage from developing spatial learning deficits, , Behavioural brain research, 2015, 10.1016/j.bbr.2015.02.053
- Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis, , Journal of neuroimmunology, 2011, 10.1016/j.jneuroim.2011.02.005
- Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology, , Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1215165110
- Microglia Ontology and Signaling, , Frontiers in cell and developmental biology, 2016, 10.3389/fcell.2016.00072
- Getting Too Old Too Quickly for Their Job: Senescent Glial Cells Promote Neurodegeneration, , Neuron, 2018, 10.1016/j.neuron.2018.11.006
- Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain: anatomical evidence of distinct roles of each subtype, , Journal of neurobiology, 1998, 10.1002/(sici)1097-4695(19980905)36:33.0.co;2-v
- GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease, , Brain, behavior, and immunity, 2015, 10.1016/j.bbi.2015.01.010
- Interactions between microglia and T cells in multiple sclerosis pathobiology, , Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2014, 10.1089/jir.2014.0019
- Interactions between the immune and neuroendocrine systems, , Progress in brain research, 2010, 10.1016/S0079-6123(08)81004-7
- Bone Marrow Chimeras to Study Neuroinflammation, , Current protocols in immunology, 2018, 10.1002/cpim.56
- Activation of the nuclear factor kappa B (NF-kappaB) and cyclooxygenase-2 (COX-2) genes in cerebral blood vessels in response to systemic inflammation, , Molecular psychiatry, 1999
- Microglia in Alzheimer's disease: A multifaceted relationship, , Brain, behavior, and immunity, 2016, 10.1016/j.bbi.2015.07.021
- Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021, 10.1007/s13311-020-00998-0
- Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain, , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 10.1523/JNEUROSCI.2840-11.2011
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Ayanna Arneaud - Maîtrise avec mémoire - En cours
- Laura Martínez Drudis - Doctorat - En cours
- Lina Lapeyre - Doctorat - En cours
- Majid Ghareghani - Post-doctorat - En cours
- Peter Thériault - Maîtrise avec mémoire - 2014/05
- Marc-André Bellavance - Doctorat - 2014/09
- Jean-Philippe Michaud - Doctorat - 2015/01
- Maude Bordeleau - Maîtrise avec mémoire - 2016/01
- Yannick Tremblay - Maîtrise avec mémoire - 2016/09
- Vincent Pons - Doctorat - 2020/09
- Adham Fani Maleki - Doctorat - 2021/01
- Pierre-Alexandre Piec - Maîtrise avec mémoire - 2022/05
- Morgan McLaughlin - Maîtrise avec mémoire - 2022/05
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- Médecine moléculaire
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