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Sheng-Xiang Lin

Professeur titulaire

Sheng-Xiang.Lin@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Cancer du sein
  • Cancers hormonaux-dépendants
  • Chimiothérapie
Maladies infectieuses et immunitaires
  • Antiviraux

Projets de recherche

  • Pre-clinical pharmacokinetic and efficacy assays with an efficient 17beta-hydroxysteroid dehydrogenase type 7 inhibitor for breast cancer therapy - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2024-03-01 au 2025-02-28
  • 3alpha-hydroxysteroid dehydrogenase type 3 as a modulator of human adipose tissue function and distribution - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2020-04-01 au 2024-03-31
  • Innovative therapeutic approaches for the 2019-novel coronavirus - Instituts de recherche en santé du Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), co-chercheur - 2021-03-01 au 2022-02-28

Publications

  • Erratum: 3D-structure of human estrogenic 17β-HSD1: Binding with various steroids (Journal of Steroid Biochemistry and Molecular Biology 69 (1999) (425-429) PII: S096007609900062X), Campbell, R.L., Gangloff, A., Zhu, D.-W., Azzi, A., Han, Q., Lin, S.X., Journal of Steroid Biochemistry and Molecular Biology, 2000, 10.1016/S0960-0760(00)00072-8
  • Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity, Poirier, D., Lin, S.-X., Thériault, J.-F., Perreault, M., Lagüe, P., Barbeau, X., Trottier, A., Maltais, R., Journal of Steroid Biochemistry and Molecular Biology, 2016, 10.1016/j.jsbmb.2015.10.020
  • Arginyl-tRNA synthetase from Escherichia coli affinity labeling with 3'-oxidized tRNA(Arg)., Wang, Y.L., Shi, J.P., Lin, S.X., Cheng, X.D., Science in China. Series B, Chemistry, life sciences & earth sciences, 1991
  • Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17β-hydroxysteroid dehydrogenase. C-18/C-19 steroid discrimination and enzyme-induced strain, Lin, S.-X., Huang, Y.-W., Gangloff, A., Campbell, R.L., Han, Q., Journal of Biological Chemistry, 2000, 10.1074/jbc.275.2.1105
  • Human 17β-hydroxysteroid dehydrogenase: overproduction using a baculovirus expression system and characterization, Lin, S.-X., Labrie, F., Li, B., Jin, J.-Z., Yang, F., Breton, R., Journal of Steroid Biochemistry and Molecular Biology, 1994, 10.1016/0960-0760(94)90132-5
  • Binary and ternary crystal structure analyses of a novel inhibitor with 17β-HSD type 1: A lead compound for breast cancer therapy, Lin, S.-X., Poirier, D., Cadot, C., Zhu, D.-W., Fournier, D., Mazumdar, M., Biochemical Journal, 2009, 10.1042/BJ20091020
  • Mapping of steroids binding to 17β-hydroxysteroid dehydrogenase type 1 using Monte Carlo energy minimization reveals alternative binding modes, Zhorov, B.S., Lin, S.-X., Blanchet, J., Biochemistry, 2005, 10.1021/bi047553x
  • Critical residues for the specificity of cofactors and substrates in human estrogenic 17β-hydroxysteroid dehydrogenase 1: Variants designed from the three-dimensional structure of the enzyme, Lin, S.-X., Laberge, S., Bellemare, V., Azzi, A., Chang, H.-J., Pineau, I., Huang, Y.-W., Molecular Endocrinology, 2001, 10.1210/me.15.11.2010
  • Two non-reactive ternary complexes of estrogenic 17β-hydroxysteroid dehydrogenase: Crystallization and preliminary structural analysis, Lin, S.-X., Poirier, D., Qi, H., Campbell, R.L., Azzi, A., Zhu, D.-W., Qiu, W., Journal of Steroid Biochemistry and Molecular Biology, 1999, 10.1016/S0960-0760(99)00036-9
  • Demonstration of a slow conformational change in liver glucokinase by fluorescence spectroscopy, Neet, K.E., Lin, S.-X., Journal of Biological Chemistry, 1990
  • Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1), Lin, S.-X., Wang, R., Li, T., Gauri, M., He, W., Gene, 2016, 10.1016/j.gene.2016.04.031
  • Stoichiometry of slow binding of palmitoyl‐CoA to liver glucokinase, NEET, K.E., VOGEL, W.K., LIN, S.‐X., International Journal of Peptide and Protein Research, 1989, 10.1111/j.1399-3011.1989.tb01583.x
  • Crystallization and preliminary X-ray diffraction analysis of E. coli arginyl-tRNA synthetase in complex form with a tRNAArg, Lin, S.-X., Wang, E.-D., Xia, X., Azzi, A., Zhou, M., Amino Acids, 2007, 10.1007/s00726-006-0436-5
  • Analysis and statistics of crystallisation success increase by composition modification of protein and precipitant mixing ratio, Lin, S.-X., Yin, D.-C., Zhu, D.-W., Mazumdar, M., Zhang, C.-Y., Protein and Peptide Letters, 2011
  • Fluorescence-energy transfer in human estradiol 17β-dehydrogenase-NADPH complex and studies on the coenzyme binding, Lin, S.-X., Li, B., European Journal of Biochemistry, 1996
  • 3D-structure of human estrogenic 17β-HSD1: Binding with various steroids, Campbell, R.L., Gongloff, A., Zhu, D.-W., Azzi, A., Han, Q., Lin, S.X., Journal of Steroid Biochemistry and Molecular Biology, 1999, 10.1016/S0960-0760(99)00062-X
  • A challenge for medicinal chemistry by the 17β-hydroxysteroid dehydrogenase superfamily: An integrated biological function and inhibition study, Adamski, J., Poirier, D., Lin, S., Current Topics in Medicinal Chemistry, 2013, 10.2174/15680266113139990004
  • Pterin and folate reduction by the Leishmania tarentolae H locus short- chain dehydrogenase/reductase PTR1, Ouellette, M., Lin, S.-X., Whiteley, J.M., Bray, T., Papadopoulou, B., Chang, C.-F., Leblanc, E., Wang, J., Archives of Biochemistry and Biophysics, 1997, 10.1006/abbi.1997.0126
  • Structural basis of the multispecificity demonstrated by 17β-hydroxysteroid dehydrogenase types 1 and 5, Zhou, M., Dabbagh, H.A., Zhu, D.-W., Azzi, A., Qiu, W., Shi, R., Lin, S.-X., Molecular and Cellular Endocrinology, 2006, 10.1016/j.mce.2005.11.035
  • How estrogen-specific proteins discriminate estrogens from androgens: a common steroid binding site architecture., Lin, S.X., Shi, R., Gangloff, A., Nahoum, V., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003
  • Cinnamomin: Separation, crystallization and preliminary X-ray diffraction study, Lin, S.-X., Liu, W.-Y., Azzi, A., Zhu, D.-W., Zou, Y.-S., Wang, T., Amino Acids, 2008, 10.1007/s00726-006-0490-z
  • Attempts to rationalize protein crystallization using relative crystallizability, Lin, S.-X., Xu, G.-J., Zhou, M., Mazumdar, M., Garneau, A., Zhu, D.-W., Journal of Structural Biology, 2006, 10.1016/j.jsb.2006.02.010
  • The crystallogenesis of a human estradiol dehydrogenase-substrate complex, Lin, S.-X., Rehse, P., Azzi, A., Zhu, D.-W., Journal of Crystal Growth, 1996
  • Rapid purification of the over-expressed membrane 3β-hydroxysteroid dehydrogenase in the presence of detergents, Lin, S.-X., Azzi, A., Breton, R., Zhou, M., Journal of Crystal Growth, 1996
  • 17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration, Lin, S.-X., Huot, J., Houle, F., Zerradi, M., Aka, J.A., Breast Cancer Research, 2012, 10.1186/bcr3207
  • Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenase., Lin, S.X., Nahoum, V., Shi, R., Gangloff, A., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003
  • Arginyl-tRNA synthetase from Escherichia coli affinity labeling with 3′-oxidized tRNAArg, Wang, Y.-l., Shi, J.-p., Lin, S.-x., Cheng, X.-d., Science in China (Scientia Sinica) Series B, 1991
  • Progress in macromolecular crystallogenesis, Bergfors, T., Giegé, R., Lin, S.-X., Crystal Growth and Design, 2007, 10.1021/cg700940x
  • Structural Insight into NS5 of Zika Virus Leading to the Discovery of MTase Inhibitors, Lin, S.-X., Boivin, G., Baz, M., Stephen, P., Journal of the American Chemical Society, 2016, 10.1021/jacs.6b10399
  • The Glutamyl-tRNA Synthetase of Escherichia coli Contains One Atom of Zinc Essential for Its Native Conformation and Its Catalytic Activity, Pézolet, M., Blochet, J.-E., Lin, S.-X., Lapointe, J., Liu, J., Biochemistry, 1993, 10.1021/bi00093a016
  • Monoclonal antibodies assisting refolding of firefly luciferase, Xu, G., Lin, S.-X., Ding, J., Xie, Z., Xu, Q., Protein Science, 2004, 10.1110/ps.04699904
  • CRIF1-CDK2 Interface Inhibitors Enhance Taxol Inhibition of the Lethal Triple-Negative Breast Cancer, Sheng-Xiang Lin, Preyesh, Ruixuan Wang, Nassira Belmessabih, Xiaoye Sang, Cancers, 2022, 10.3390/cancers14040989
  • Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78, Lin, S.-X., Doillon, C.J., Xu, D., Li, T., Aka, J.A., Wang, X.-Q., Journal of Steroid Biochemistry and Molecular Biology, 2017, 10.1016/j.jsbmb.2017.06.009
  • Membrane-bound human 3β-hydroxysteroid dehydrogenase: Overexpression with His-tag using a baculovirus system and single-step purification, Lin, S.-X., Qi, H., Lu, M.-L., Huang, Y.-W., Protein Expression and Purification, 2000, 10.1006/prep.1999.1180
  • Human estrogenic 17β-hydroxysteroid dehydrogenase: Predominance of estrone reduction and its induction by NADPH, Lin, S.-X., Jin, J.-Z., Biochemical and Biophysical Research Communications, 1999, 10.1006/bbrc.1999.0704
  • Monte Carlo-Minimized energy profile of estradiol in the ligand- binding tunnel of 17β-hydroxysteroid dehydrogenase: Atomic mechanisms of steroid recognition, Lin, S.X., Zhorov, B.S., Proteins: Structure, Function and Genetics, 2000, 10.1002/(SICI)1097-0134(20000301)38:4<414::AID-PROT7>3.0.CO;2-X
  • Crystal structures of the multispecific 17β-hydroxysteroid dehydrogenase type 5: Critical androgen regulation in human peripheral tissues, Lin, S.-X., Labrie, F., Zhou, M., Qiu, W., Molecular Endocrinology, 2004, 10.1210/me.2004-0032
  • Structure of the Human 3α-Hydroxysteroid Dehydrogenase Type 3 in Complex with Testosterone and NADP at 1.25-Å Resolution, Lin, S.-X., Breton, R., Labrie, F., Luu-The, V., Zhorov, B.S., Cantin, L., Zhu, D.-W., Legrand, P., Gangloff, A., Nahoum, V., Journal of Biological Chemistry, 2001, 10.1074/jbc.M105610200
  • Role of 17β-hydroxysteroid dehydrogenases in sex steroid formation in peripheral intracrine tissues, Labrie, C., Simard, J., Lin, S.-X., Luu-The, V., Labrie, F., Trends in Endocrinology and Metabolism, 2000, 10.1016/S1043-2760(00)00342-8
  • The second space experiment of protein crystallization with domestic facilities, Bi, R., Lin, S., He, H., Teng, M., Liu, Y., Li, H., Han, Q., Wu, S., Xu, Q., Hua, Z., Zhou, Y., Niu, X., Pan, J., Wang, Y., Science in China, Series C: Life Sciences, 1996
  • The zinc-binding site of a class I aminoacyl-tRNA synthetase is a SWIM domain that modulates amino acid binding via the tRNA acceptor arm, Lapointe, J., Roy, S., Lin, S.-X., Gauthier, J., Dubois, D.Y., Banerjee, R., European Journal of Biochemistry, 2004, 10.1111/j.1432-1033.2003.03976.x
  • Magnet used for protein crystallization: Novel attempts to improve the crystal quality, Ataka, M., Wakayama, N.I., Xu, G.-J., Azzi, A., Zhou, M., Lin, S.-X., Biochemical and Biophysical Research Communications, 2000, 10.1006/bbrc.2000.3294
  • Higher specific activity of the Escherichia coli glutamylt-RNA synthetase purified to homogeneity by a six-hour procedure, Lapointe, J., Roy, P.H., Liu, J., Brisson, A., Lin, S.-x., Protein Expression and Purification, 1992, 10.1016/1046-5928(92)90058-5
  • Human 17β-hydroxysteroid dehydrogenase-ligand complexes: Crystals of different space groups with various cations and combined seeding and co-crystallization, Lin, S.-X., Azzi, A., Xie, B.-X., Campbell, R.L., Qiu, W., Han, Q., Zhu, D.-W., Journal of Crystal Growth, 1999
  • Preparation of the apoenzyme and holoenzyme forms of human 17β-hydroxysteroid dehydrogenase, Lin, S.-X., Wang, J.-Y., Azzi, A., Jin, J.-Z., Journal of Chromatography B: Biomedical Sciences and Applications, 1993, 10.1016/0378-4347(93)80236-W
  • Synthesis of a first estradiol-adenosine hybrid compound, Lin, S.-X., Bérubé, M., Boivin, R.P., Poirier, D., Synthetic Communications, 2003, 10.1081/SCC-120023440
  • Genomic data on breast cancer transcript profile modulation by 17beta-hydroxysteroid dehydrogenase type 1 and 17-beta-estradiol, Lin, S.-X., Calvo, E.-L., Aka, J.A., Data in Brief, 2016, 10.1016/j.dib.2016.11.010
  • Crystallization and preliminary X-ray diffraction analysis of arginyl- tRNA synthetase from Escherichia coli, Lin, S.-X., Wang, Y.-L., Campbell, R.L., Wang, E.-D., Zhou, M., Protein Science, 1997
  • In vitro interactions between mammary fibroblasts (Hs 578Bst) and cancer epithelial cells (MCF-7) modulate aromatase, steroid sulfatase and 17β-hydroxysteroid dehydrogenases, Doillon, C.J., Lin, S.-X., Diorio, C., Sang, X., Wang, X., Molecular and Cellular Endocrinology, 2015, 10.1016/j.mce.2015.05.032
  • Interaction of Androst-5-ene-3β,17β-diol and 5α-androstane- 3β,17β-diol with estrogen and androgen receptors: A combined binding and cell study, Lin, S.-X., Wang, W.-Q., Chen, J., Journal of Steroid Biochemistry and Molecular Biology, 2013, 10.1016/j.jsbmb.2013.01.012
  • Is dehydroepiandrosterone a hormone?, Labrie, C., Pelletier, G., Simard, J., Lin, S.-X., Bélanger, A., Luu-The, V., Labrie, F., Journal of Endocrinology, 2005, 10.1677/joe.1.06264
  • An extensive study of protein phase diagram modification: Increasing macromolecular crystallizability by temperature screening, Lin, S.-X., Zhang, Y.-L., Zou, Y.-S., Song, J., Wang, T., Zhu, D.-W., Lin, Y.-B., Crystal Growth and Design, 2008, 10.1021/cg800698p
  • Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway, Lin, S.-X., Xu, G., Shan, Y., Li, C., Zhu, D.-W., Chen, Z.-Y., Shi, R., PLoS ONE, 2013, 10.1371/journal.pone.0071242
  • Molecular therapy of breast cancer: Progress and future directions, Zhou, M., Azzi, A., Wang, C., Poirier, D., Mazumdar, M., Chen, J., Lin, S.-X., Nature Reviews Endocrinology, 2010, 10.1038/nrendo.2010.92
  • Human oestrogenic 17β-hydroxysteroid dehydrogenase specificity: Enzyme regulation through an NADPH-dependent substrate inhibition towards the highly specific oestrone reduction, Lin, S.-X., Yang, F., Huang, Y.-W., Garneau, A., Gangloff, A., Biochemical Journal, 2001, 10.1042/0264-6021:3560269
  • Subunit identity of the dimeric 17β-hydroxysteroid dehydrogenase from human placenta, Labrie, F., Luu-The, V., Zhu, D.-W., Breton, R., Jin, J.-Z., Yang, F., Lin, S.-X., Journal of Biological Chemistry, 1992
  • Intracrinology: Role of the family of 17β-hydroxysteroid dehydrogenases in human physiology and disease, Belanger, A., Pelletier, G., El-Alfy, M., Labrie, C., Simard, J., Lin, S.X., Luu-The, V., Labrie, F., Journal of Molecular Endocrinology, 2000
  • Molecular Mechanism of Inhibition of Steroid Dehydrogenases by Licorice‐Derived Steroid Analogs in Modulation of Steroid Receptor Function, LIN, S.‐X., LABRIE, F., ZHU, D.‐W., PANGBORN, W., DUAX, W.L., ERMAN, M., PLETNEV, V., WAWRZAK, Z., GHOSH, D., Annals of the New York Academy of Sciences, 1995, 10.1111/j.1749-6632.1995.tb31388.x
  • Arginyl-tRNA Synthetase from Escherichia coli, Purification by Affinity Chromatography, Properties, and Steady-State Kinetics, Wang, Y.L., Shi, X D Cheng, J.P., Lin, S.X., Biochemistry, 1988, 10.1021/bi00417a022
  • Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: Structure of the enzyme-ADT complex, Lin, S.-X., Rehse, P., Shi, R., Chang, H.-J., Journal of Biological Chemistry, 2004, 10.1074/jbc.M310446200
  • Purification, reconstitution, and steady-state kinetics of the trans-membrane 17β-hydroxysteroid dehydrogenase 2, Lin, S.-X., Huang, Y.-W., Lu, M.-L., Journal of Biological Chemistry, 2002, 10.1074/jbc.M111726200
  • Crystal structure of chloramphenicol acetyltransferase B2 encoded by the multiresistance transposon Tn2424, Lin, S.-X., Lapointe, J., Roy, P.H., Zhou, M., Lu, M.-L., Shi, R., Qiu, W., Proteins: Structure, Function and Genetics, 2004, 10.1002/prot.20250
  • Crystallization of human estrogenic 17β-hydroxysteroid dehydrogenase under microgravity, Lin, S.-X., Labrie, F., Mao, Y., Zhou, M., Zhu, D.-W., Journal of Crystal Growth, 1995, 10.1016/0022-0248(95)00252-9
  • Human 3α-hydroxysteroid dehydrogenase type 3: Structural clues of 5α-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth, Lin, S.-X., Labrie, F., Shang, P., Zhu, D.-W., Thériault, J.-F., Wang, X.-Q., Hu, X.-J., Zhang, B., Biochemical Journal, 2016, 10.1042/BCJ20160083
  • Fast Kinetic Study of Yeast Phenylalanyl-tRNA Synthetase: Role of tRNAp in the Discrimination between Tyrosine and Phenylalanine, Remy, P., Baltzinger, M., Lin, S.X., Biochemistry, 1984, 10.1021/bi00313a015
  • Fast Kinetic Study of Yeast Phenylalanyl-tRNA Synthetase: An Efficient Discrimination between Tyrosine and Phenylalanine at the Level of the Aminoacyladenylate·Enzyme Complex, Remy, P., Baltzinger, M., Lin, S.X., Biochemistry, 1983, 10.1021/bi00272a024
  • RNA-dependent RNA polymerase: Addressing Zika outbreak by a phylogeny-based drug target study, Lin, S.-X., Stephen, P., Chemical Biology and Drug Design, 2017, 10.1111/cbdd.13054
  • Deep Drug Discovery of Mac Domain of SARS-CoV-2 (WT) Spike Inhibitors: Using Experimental ACE2 Inhibition TR-FRET Assay, Screening, Molecular Dynamic Simulations and Free Energy Calculations, Sheng-Xiang Lin, Saleem Iqbal, Bioengineering, 2023, 10.3390/bioengineering10080961
  • Human SARS-coronavirus RNA-dependent RNA polymerase: Activity determinants and nucleoside analogue inhibitors, Lin, S.-X., Azzi, A., Proteins: Structure, Function and Genetics, 2004, 10.1002/prot.20194
  • The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology, Bélanger, A., Breton, R., Simard, J., Labrie, C., Lin, S.-X., Luu-The, V., Labrie, F., Steroids, 1997, 10.1016/S0039-128X(96)00174-2
  • Substrate inhibition of 17β-HSD1 in living cells and regulation of 17β-HSD7 by 17β-HSD1 knockdown, Lin, S.-X., Chen, G., Thériault, J.-F., Han, H., Journal of Steroid Biochemistry and Molecular Biology, 2017, 10.1016/j.jsbmb.2017.05.011
  • Preparative fast purification procedure of various proteins for crystallization, Zhou, M., Lapointe, J., Sailofsky, B., Lin, S.-X., Journal of Crystal Growth, 1992, 10.1016/0022-0248(92)90252-E
  • Mimicking postmenopausal steroid metabolism in breast cancer cell culture: Differences in response to DHEA or other steroids as hormone sources, Lin, S.-X., Xu, D., Journal of Steroid Biochemistry and Molecular Biology, 2016, 10.1016/j.jsbmb.2015.07.009
  • Comparison of functional proteomic analyses of human breast cancer cell lines T47D and MCF7, Lin, S.-X., Aka, J.A., PLoS ONE, 2012, 10.1371/journal.pone.0031532
  • Crystallization and preliminary crystallographic analysis of the snake muscle fructose 1,6-bisphosphatase, Lin, S.-X., Zhao, F.-K., Azzi, A., Rehse, P.H., Xu, G.-J., Zhu, D.-W., Acta Crystallographica Section D: Biological Crystallography, 1999, 10.1107/S0907444999004977
  • Purification, crystallization and preliminary X-ray diffraction results of human 17β-hydroxysteroid dehydrogenase type 5, Lin, S.-X., Gangloff, A., Chang, H.-J., Qiu, W., Zhou, M., Acta Crystallographica Section D: Biological Crystallography, 2002, 10.1107/S0907444902005255
  • A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity., Lin, S.X., Poirier, D., Tremblay, M.R., Boivin, R.P., Dupuis, P., Gangloff, A., Campbell, R.L., Qiu, W., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002
  • Synergistic control of sex hormones by 17β-HSD type 7: A novel target for estrogen-dependent breast cancer, Lin, S.-X., Doillon, C.J., Poirier, D., Thériault, J.-F., Gérard, C., Wang, X., Journal of Molecular Cell Biology, 2015, 10.1093/jmcb/mjv028
  • Chromatography of hydroxysteroid dehydrogenases, Zhou, M., Li, B., Xie, B., Lin, S.-X., Journal of Chromatography B: Biomedical Applications, 1996, 10.1016/0378-4347(96)00180-6
  • Current physico-biochemistry in steroid research and status of structural biology for steroid-converting enzymes, Penning, T.M., Hu, X.J., Shi, R., Lin, S.X., Journal of Steroid Biochemistry and Molecular Biology, 2016, 10.1016/j.jsbmb.2016.05.011
  • Crystallization and preliminary X-ray diffraction analysis of the chloramphenicol acetyltransferase from Tn2424, Lin, S.-X., Roy, P.H., Lapointe, J., Nahoum, V., Campbell, R.L., Qiu, W., Lu, M.-L., Zhou, M., Acta Crystallographica Section D: Biological Crystallography, 2001, 10.1107/S0907444900016802
  • A technique of protein addition for repeated enlargement of protein crystals in solution, Lin, S.-X., Han, Q., Techniques in Protein Chemistry, 1996, 10.1016/S1080-8914(96)80040-8
  • Rapid purification yielding highly active 17β-hydroxysteroid dehydrogenase: application of hydrophobic interaction and affinity fast protein liquid chromatography, Lin, S.-X., Wang, J.-Y., Zhu, D.-W., Yang, F., Journal of Chromatography B: Biomedical Sciences and Applications, 1992, 10.1016/0378-4347(92)80304-9
  • Cofactor Hydrogen Bonding onto the Protein Main Chain is Conserved in the Short Chain Dehydrogenase/Reductase Family and Contributes to Nicotinamide Orientation, Lin, S.-X., Shi, R., Journal of Biological Chemistry, 2004, 10.1074/jbc.M313156200
  • Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 å resolution, Lin, S.-X., Labrie, F., Pangborn, W., Duax, W.L., Wawrzak, Z., Zhu, D.-W., Pletnev, V.Z., Ghosh, D., Structure, 1995, 10.1016/S0969-2126(01)00183-6
  • Yeast Phenylalanyl-tRNA Synthetase: Symmetric Behavior of the Enzyme during Activation of Phenylalanine As Shown by a Rapid Kinetic Investigation, Remy, P., Lin, S.X., Baltzinger, M., Biochemistry, 1983, 10.1021/bi00272a023
  • 17β-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production, Lin, S.-X., Poirier, D., Chen, C.-Q., Mazumdar, M., Aka, J.A., Molecular Endocrinology, 2010, 10.1210/me.2009-0468
  • Endocrine and intracrine sources of androgens in women: Inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone, Pelletier, G., Lin, S.-X., Simard, J., Bélanger, A., Labrie, C., Luu-The, V., Labrie, F., Endocrine Reviews, 2003, 10.1210/er.2001-0031
  • Structure analysis of a new psychrophilic marine protease, Lin, S.-X., Zhou, M., Hu, X.-J., Han, Y., Hao, J.-H., Wang, Q.-H., Li, T., Sun, M., Zhang, S.-C., PLoS ONE, 2011, 10.1371/journal.pone.0026939
  • Human 17β-hydroxysteroid dehydrogenase: optical properties of its complex with NADP+, Lin, S.-X., Jin, J.-Z., Zhu, D.-W., Journal of Steroid Biochemistry and Molecular Biology, 1995, 10.1016/0960-0760(94)00144-B
  • Human dehydroepiandrosterone sulfotransferase: Purification and characterization of a recombinant protein, Lin, S.-X., Zhou, M., Chang, H.-J., Journal of Steroid Biochemistry and Molecular Biology, 2001, 10.1016/S0960-0760(01)00048-6
  • Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity, Lin, S.-X., Shang, P., Zhou, M., Hu, X.-J., Zhu, D.-W., Zhang, B., Journal of Steroid Biochemistry and Molecular Biology, 2014, 10.1016/j.jsbmb.2014.01.003
  • Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1, Lin, S.-X., Calvo, E.-L., Aka, J.A., Molecular and Cellular Endocrinology, 2017, 10.1016/j.mce.2016.08.026
  • Corrections: The Glutamyl-tRNA Synthetase of Escherichia coli Contains One Atom of Zinc Essential for Its Native Conformation and Its Catalytic Activity: (Biochemistry (1993) 32(42) (11390–11396) (10.1021/bi00093a016)), Lapointe, J., Pézolet, M., Blochet, J.-E., Lin, S.-X., Liu, J., Biochemistry, 1993, 10.1021/bi00214a023
  • Design and synthesis of bisubstrate inhibitors of type 1 17β-hydroxysteroid dehydrogenase: Overview and perspectives, Lin, S.-X., Mazumdar, M., Poirier, D., Fournier, D., European Journal of Medicinal Chemistry, 2008, 10.1016/j.ejmech.2008.01.044
  • Three-dimensional modeling of cytomegalovirus DNA polymerase and preliminary analysis of drug resistance, Lin, S.-X., Boivin, G., Gilbert, C., Azzi, A., Shi, R., Proteins: Structure, Function and Genetics, 2006, 10.1111/j.1365-2052.2006.01446.x
  • Crystallization and preliminary x-ray crystallographic analysis of the human type 3 3α-hydroxysteroid dehydrogenase at 1.8 Å resolution, Lin, S.-X., Breton, R., Labrie, F., Luu-The, V., Rehse, P., Nahoum, V., Cantin, L., Zhu, D.-W., Acta Crystallographica Section D: Biological Crystallography, 2001, 10.1107/S0907444901001160
  • Impact of intracrinology in the treatment and prevention of breast and prostate cancer, and menopause | Impact de l'intracrinologie dans la therapeutique et la prevention des cancers du sein et de la prostate, et de la menopause, Cusan, L., Candas, B., Lin, S.-X., Labrie, Cl., Luu-The, V., Simard, J., Belanger, A., Labrie, F., Revue Francaise d'Endocrinologie Clinique - Nutrition et Metabolisme, 1999
  • Purification, refolding, crystallization and diffraction analysis of the native and selenomethionine-substituted rat epidymal-specific lipocalin, Lin, S.-X., Zhang, R.-G., Jin, Y.-X., Shi, Y., Azzi, A., Zou, Y.-S., Zhu, D.-W., Wang, T., Crystal Growth and Design, 2007, 10.1021/cg700945a
  • Crystallization and preliminary crystallographic data of fructose-1,6-bisphosphatase from human muscle, Lin, S.-X., Zhao, F.-K., Shi, R., Rehse, P.H., Xu, G.-J., Zhu, D.-W., Acta Crystallographica Section D: Biological Crystallography, 2001, 10.1107/S0907444901004371
  • Crystallization of the membrane-associated annexin B1: Ro y, Lin, S.-X., Sun, S.-H., Chen, C.-Q., Rehse, P., Zhu, D.-W., Azzi, A., Xu, Y.-F., Ding, F.-X., Crystal Growth and Design, 2010, 10.1021/cg901046f
  • Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet, Boivin, G., Lin, S.-X., Goyette, N., Azzi, A., Gilbert, C., Antimicrobial Agents and Chemotherapy, 2011, 10.1128/AAC.00334-11
  • Opposite effect of two cytomegalovirus DNA polymerase mutations on replicative capacity and polymerase activity, Boivin, G., Lin, S.-X., Azzi, A., Martin, M., Antiviral Therapy, 2010, 10.3851/IMP1565
  • Affinity labelling of E. coli leucyl-tRNA synthetase with 3'-oxidized tRNA(Leu)., Wang, Y.L., Shi, J.P., Lin, S.X., Huang, S.T., Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences / Chung-kuo k"o hsueh yuan, chu pan, 1987
  • Crystallogenesis of steroid-converting enzymes and their complexes: Enzyme-ligand interaction studies and inhibitor design facilitated by complex structures, Lin, S.-X., Azzi, A., Zhu, D.-W., Zhou, M., Mazumdar, M., Crystal Growth and Design, 2007, 10.1021/cg700709k
  • Crystallization and preliminary crystallographic results of apo and complex forms of human dehydroepiandrosterone sulfotransferase, Lin, S.-X., Luu-The, V., Chang, H.-J., Rehse, P., Zhou, M., Acta Crystallographica Section D: Biological Crystallography, 2001, 10.1107/S0907444901010964
  • Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells, Lin, S.-X., Chen, J., Wang, W.-Q., Zhang, C.-Y., Journal of Steroid Biochemistry and Molecular Biology, 2015, 10.1016/j.jsbmb.2014.09.017
  • The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells, Lin, S.-X., Yin, D.-C., Chen, J., Zhang, C.-Y., PLoS ONE, 2012, 10.1371/journal.pone.0029835
  • Estrone and estradiol C-16 derivatives as inhibitors of type 1 17β-hydroxysteroid dehydrogenase, Lin, S.-X., Boivin, R.P., Azzi, A., Chang, H.-J., Poirier, D., Molecular and Cellular Endocrinology, 2006, 10.1016/j.mce.2005.10.017
  • Protein crystal growth on board Shenzhou 3: A concerted effort improves crystal diffraction quality and facilitates structure determination, Lin, S.-X., Zhu, D.-W., Zhou, M., Shi, R., Nahoum, V., Delbaere, L.T.J., Colelesage, J., Bi, R.-C., Wang, Y.-P., Zhou, J.-X., Cang, H.-X., Han, Y., Biochemical and Biophysical Research Communications, 2004, 10.1016/j.bbrc.2004.09.166
  • Structure-based inhibitor design for an enzyme that binds different steroids: A potent inhibitor for human type 5 17β-hydroxysteroid dehydrogenase, Lin, S.-X., Labrie, F., Luu-The, V., Ghanmi, D., Azzi, A., Mazumdar, M., Zhou, M., Qiu, W., Journal of Biological Chemistry, 2007, 10.1074/jbc.M606784200
  • Reductive 17β-hydroxysteroid dehydrogenases in the sulfatase pathway: Critical in the cell proliferation of breast cancer, Lin, S.-X., Mazumdar, M., Aka, J.A., Molecular and Cellular Endocrinology, 2009, 10.1016/j.mce.2008.10.042
  • Studies on the three-dimensional structure of estrogenic 17β-hydroxysteroid dehydrogenase, Pangborn, W., Duax, W.L., Pletnev, V., Ghosh, D., Labrie, F., Breton, R., Campbell, R.L., Azzi, A., Zhu, D.-W., Lin, S.-X., Journal of Endocrinology, 1996
  • Chemical synthesis of 16β-propylaminoacyl derivatives of estradiol and their inhibitory potency on type 1 17β-hydroxysteroid dehydrogenase and binding affinity on steroid receptors, Poirier, D., Lin, S.-X., Tremblay, M.R., Steroids, 2001, 10.1016/S0039-128X(01)00116-7
  • Crystallization and preliminary crystal structure of the complex of 17β-hydroxysteroid dehydrogenase with a dual-site inhibitor, Lin, S.-X., Labrie, F., Campbell, R., Zhu, D.-W., Journal of Steroid Biochemistry and Molecular Biology, 1999, 10.1016/S0960-0760(99)00111-9
  • Structure function analysis of West Nile virus RNA dependent RNA polymerase: Molecular model and implications for drug design, Lin, S.-X., Azzi, A., Medicinal Chemistry, 2007, 10.2174/157340607781745438
  • Search of Novel Small Molecule Inhibitors for the Main Protease of SARS-CoV-2, Sheng-Xiang Lin, Wenfa Zhang, Viruses, 2023, 10.3390/v15020580
  • A microcrystal selection technique in protein crystallization, Lin, S.-X., Han, Q., Journal of Crystal Growth, 1996
  • 17beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation, Lin, S.-X., Wang, R., Aka, J.A., Xu, D., Journal of Steroid Biochemistry and Molecular Biology, 2017, 10.1016/j.jsbmb.2017.04.009
  • The study of crystallization of estrogenic 17β-hydroxysteroid dehydrogenase with DHEA and DHT at elevated temperature, Lin, S.-X., Han, Q., Biochemical and Biophysical Research Communications, 2000, 10.1006/bbrc.2000.3631
  • Interplay between catalysts and substrates for activity of class ib aminoacyl-trna synthetases and implications for pharmacology, Giegé, R., Lin, S.-X., Stephen, P., Current Topics in Medicinal Chemistry, 2016
  • Crystallization and preliminary X-ray diffraction analysis of the complex of human placental 17β-hydroxysteroid dehydrogenase with NADP+, Lin, S.-X., Duax, W.L., Pangborn, W., Ghosh, D., Breton, R., Lee, X., Zhu, D.-W., Journal of Molecular Biology, 1993, 10.1006/jmbi.1993.1578
  • Interactions between Escherichia coli Arginyl-tRNA Synthetase and Its Substrates, Wang, Y.L., Wang, Q., Lin, S.X., Biochemistry, 1988, 10.1021/bi00417a023
  • Dendritic Cell Immunoreceptor Is a New Target for Anti-AIDS Drug Development: Identification of DCIR/HIV-1 Inhibitors, Gilbert, C., Tremblay, M.J., St-Gelais, K.P., Allaire, G., Lin, S.-X., Azzi, A., Lambert, A.A., PLoS ONE, 2013, 10.1371/journal.pone.0067873
  • Crystal structure of human estrogenic 17β-hydroxysteroid dehydrogenase complexed with 17β-estradiol, Lin, S.-X., Labrie, F., Campbell, R.L., Zhu, D.-W., Rehse, P.H., Azzi, A., Nature Structural Biology, 1996, 10.1038/nsb0896-665
  • Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate, Lin, S.-X., Zhou, M., Rehse, P.H., Biochemical Journal, 2002
  • Electrophoresis of hydrophobic proteins, Xie, B., Huang, Y.-W., Gangloff, A., Lin, S.-X., Analytica Chimica Acta, 1999, 10.1016/S0003-2670(98)00491-7
  • The ternary structure of the double-headed arrowhead protease inhibitor API-A complexed with two trypsins reveals a novel reactive site conformation, Chen, Y., Chi, C.-W., Lin, S.-X., Jiang, C., Zhou, C.-Z., Bao, R., Journal of Biological Chemistry, 2009, 10.1074/jbc.M109.022095
  • Good crystals, still a challenge for structural biology, Giegé, R., McPherson, A., Lin, S.-X., Crystal Growth and Design, 2007, 10.1021/cg700745r
  • Crystal structure of native cinnamomin isoform III and its comparison with other ribosome inactivating proteins, Lin, S.-X., Liu, W.-Y., Zou, Y.-S., Zhu, D.-W., Wang, T., Azzi, A., Proteins: Structure, Function and Bioinformatics, 2009, 10.1002/prot.22251
  • Estradiol-adenosine hybrid compounds designed to inhibit type 1 17β-hydroxysteroid dehydrogenase, Lin, S.-X., Qiu, W., Bérubé, M., Tremblay, M.R., Boivin, R.P., Poirier, D., Journal of Medicinal Chemistry, 2005, 10.1021/jm058235e

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Ruixuan Wang - Doctorat - En cours
  • Nassim Lahdiri - Doctorat - En cours
  • Peng Su - Doctorat - En cours
  • Bo Zhang - Doctorat - 2014/05
  • Xiao Qiang Wang - Doctorat - 2015/01
  • Le Yi Lin - Maîtrise avec mémoire - 2015/05
  • Dan Xu - Doctorat - 2015/09
  • Hui Han - Doctorat - 2018/09
  • Tang Li - Doctorat - 2019/01
  • Xiaoye Sang - Doctorat - 2019/09
  • Nassira Belmessabih - Maîtrise avec mémoire - 2023/01
  • Wenfa Zhang - Doctorat - 2024/01

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Médecine moléculaire

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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