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Silvia Pozzi
Professeure adjointe
Centre thématique de recherche en neurosciences
Centre de recherche CERVO
Ce profil n’a pas encore été complété.
Contribution à la recherche
Projets de recherche
- Canada Research Chair in Central and Peripheral Cellular Networks in ALS - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2023-02-01 au 2028-01-31
- Molecular regulators of extracellular matrix remodeling during Amyotrophic Lateral Sclerosis - Brain Canada Foundation - Futurs leaders canadiens de la recherche sur le cerveau 2020, chercheur principal - 2024-09-01 au 2026-08-31
- Unravelling the functions of Peptidyl-Prolyl Isomerase A in axonal transport and neuromuscular junction development and maintenance - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2021-04-01 au 2026-03-31
- Internation Brain Research Organization Award - International Brain Research Organization, chercheur principal - 2022-10-01 au 2024-09-30
- Fonds de démarrage Centre de recherches CERVO - Fondation CERVO, chercheur principal - 2020-09-01 au 2023-09-01
- Extracellular PPIA: a new target for an antibody-based therapeutic approach for ALS - Société canadienne de la sclérose latérale amyotrophique - Career transition award program 2015, chercheur principal - 2020-09-01 au 2023-06-30
- Programme de soutien aux nouveaux chercheurs - Université Laval - Fonds internes - Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, chercheur principal - 2021-07-01 au 2023-06-30
- Unraveling the role of PPIA/EMMPRIN pathway in the communication between Schwann cells and motor neurons in ALS - The Banting research foundation - Discovery Award, chercheur principal - 2022-07-01 au 2023-06-30
- La communication cellulaire dans le système nerveux central et périphérique: des mécanismes aux thérapies pour la SLA - Ministère de la Santé et des Services sociaux, Stoelting Co., Fondation Canadienne pour l'innovation (La), CIUSSS - CN - CERVO - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2022-04-01 au 2023-03-31
- Use of optogenetic-TDP43 to shed light on the dying-back hypothesis in ALS - Université Laval - Fonds internes - BDR - Contributions, chercheur principal - 2022-04-01 au 2023-03-31
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Publications
- Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology, Jean-Pierre Julien, Claude Gravel, Jasna Kriz, Daniel Phaneuf, Christine Bareil, Geneviève Soucy, Karine Valérie Plourde, Reza Rahimian, Philippe Codron, Sai Sampath Thammisetty, Silvia Pozzi, Journal of Clinical Investigation, 2019, 10.1172/JCI123931
- Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: Implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis, Bonetto, V., Bendotti, C., Battaglia, E., Gensano, F., Lidonnici, D., Spaltro, G., Pasetto, L., Bisighini, C., Fiordaliso, F., Tortarolo, M., Pozzi, S., Basso, M., Journal of Biological Chemistry, 2013, 10.1074/jbc.M112.425066
- Nitroproteomics of peripheral blood mononuclear cells from patients and a rat model of ALS, Bonetto, V., Bendotti, C., Mora, G., Basso, M., Marinou, K., Garbelli, S., Mantovani, S., Pozzi, S., Nardo, G., Antioxidants and Redox Signaling, 2009, 10.1089/ars.2009.2548
- Monoclonal full-length antibody against TAR DNA binding protein 43 reduces related proteinopathy in neurons, Jean-Pierre Julien, Christine Bareil, Kallol Dutta, Pierre Junior Cordeau, Laurence Renaud, Geneviève Soucy, Philippe Codron, Silvia Pozzi, JCI Insight, 2020, 10.1172/jci.insight.140420
- Chronic Administration of Pimozide Fails to Attenuate Motor and Pathological Deficits in Two Mouse Models of Amyotrophic Lateral Sclerosis, Julien, J.-P., Thammisetty, S.S., Pozzi, S., Neurotherapeutics, 2018, 10.1007/s13311-018-0634-3
- Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition, Chantelle F. Sephton, Jean-Pierre Julien, Paul A. Dutchak, Silvia Pozzi, Daniel Phaneuf, Alicia Rodgers, Laetitia Marcadet, Bastien Glasson, Pauline A. Gelon, Antoine Desmeules, Mari Carmen Pelaez, Acta Neuropathologica Communications, 2023, 10.1186/s40478-023-01671-1
- Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1, Neil R. Cashman, W. Ted Allison, Jean-Pierre Julien, Anke Dijkstra, Steven S. Plotkin, Andrei Roman, Silvia Pozzi, Sarah Louadi, Luke McAlary, Michéle G. DuVal, Edward Pokrishevsky, Journal of Biological Chemistry, 2024, 10.1016/j.jbc.2024.107207
- Antibody-Based Therapeutic Interventions for Amyotrophic Lateral Sclerosis: A Systematic Literature Review, , Frontiers in Neuroscience, 2021, 10.3389/fnins.2021.790114
- Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia, , Brain, 2021, 10.1093/brain/awab333
- Targeting extracellular cyclophilin a reduces neuroinflammation and extends survival in a mouse model of amyotrophic lateral sclerosis, Bonetto, V., Bendotti, C., Tortarolo, M., Freschi, M., Fischer, G., Malešević, M., Callea, L., Monsurrò, M.R., Trojsi, F., Chiesa, R., Restelli, E., Bigini, P., Castellaneta, V., De Simoni, M.G., Fumagalli, S., Estevez, A.G., Basso, M., Castelnovo, M., Pozzi, S., Pasetto, L., Journal of Neuroscience, 2017, 10.1523/JNEUROSCI.2462-16.2016
- Estrogen action in neuroprotection and brain inflammation, Vegeto, E., Maggi, A., Benedusi, V., Pozzi, S., Annals of the New York Academy of Sciences, 2006, 10.1196/annals.1386.035
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A Mouse Model of Familial ALS Has Increased CNS Levels of Endogenous Ubiquinol
9/10 and Does Not Benefit from Exogenous Administration of Ubiquinol10 , Gobbi, M., Bendotti, C., Beghi, E., Caccia, S., Bonetto, V., Pozzi, S., Guiso, G., Tortarolo, M., Papa, S., Marino, M., Lucchetti, J., PLoS ONE, 2013, 10.1371/journal.pone.0069540 - Cyclophilin A knock-out mice develop a pure frontotemporal dementia phenotype with marked TDP-43 pathology, Bonetto, V., Forloni, G., Carli, M., Cerovic, M., Micotti, E., Pozzi, S., Pasetto, L., bioRxiv, 2020, 10.1101/2020.06.08.129528
- Amyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cells, Bonetto, V., Bendotti, C., Mora, G., Corbo, M., Lunetta, C., Bazzoni, G., Paris, L., Torri, V., Monteforte, M., Papetti, L., Marinou, K., Mantovani, S., Garbelli, S., Spano, G., Lauranzano, E., Pignataro, M., Pozzi, S., Nardo, G., PLoS ONE, 2011, 10.1371/journal.pone.0025545
- Tryptophan residues in TDP-43 and SOD1 mediate the cross-seeding and toxicity of SOD1, Neil R. Cashman, W. Ted Allison, Jean-Pierre Julien, Anke Dijkstra, Steven S Plotkin, Andrei Roman, Silvia Pozzi, Sarah Louadi, Luke McAlary, Michèle G. DuVal, Edward Pokrishevsky, 2020, 10.1101/2020.07.27.224188
- Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes, Bonetto, V., Bendotti, C., Mora, G., Corbo, M., Lunetta, C., Nardo, G., Mombrini, M., Paolella, K., Massignan, T., Stucchi, R., Pasetto, L., Pozzi, S., Lauranzano, E., Brain, 2015, 10.1093/brain/awv005
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Shanna Pigeyre - Maîtrise avec mémoire - En cours
- Angie Milena Bustos Rangel - Doctorat - En cours
- Marion Boyer - Doctorat - En cours
- Ariane Gosselin - Maîtrise avec mémoire - En cours
- Amélie Poulin-Brière - Doctorat - En cours
- Gloria Nwamaka Edozie - Maîtrise avec mémoire - 2023/09
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.