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Steve Lacroix
Professeur titulaire
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
Contribution à la recherche
Thématiques de recherche de la Faculté de médecine
- Immunologie-infectiologie
- Médecine régénératrice et médecine moléculaire
- Neurosciences et santé mentale
Domaines de recherche
- Neuro-inflammation
- Neuroscience cellulaire
- Neurodégénérescence
- Immunité innée
- Auto-immunité
- Étude des cellules gliales
- Thérapie génique et moléculaire
Projets de recherche en cours
- Identifying the role of inflammatory cytokines in pain after nervous system injury. - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2025-04-01 au 2030-03-31
- Identifying the role of proinflammatory cytokines in pain in multiple sclerosis - Société canadienne de la sclérose en plaques - Subventions axées sur les découvertes, chercheur principal - 2025-04-01 au 2028-03-31
- Untangling secondary degeneration and pain from inflammation after spinal cord injury - Wings for Life Spinal Cord Research Foundation, chercheur principal - 2024-07-01 au 2026-06-30
- Role of inflammation in recovery after spinal cord injury - Instituts de recherche en santé du Canada - Subvention Projet, University of Alberta, co-chercheur - 2021-04-01 au 2026-03-01
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Financements des 2 dernières années
- Platelets and neutrophils: the two culprits mediating pain in inflammatory arthritis - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2020-04-01 au 2025-03-31
- Elucidating the role of the IL-1 system in the pathogenesis of CNS autoimmunity - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
- Thérapie génique ciblée dans un modèle de sclérose en plaques - Fonds de recherche du Québec - Santé, co-chercheur - 2021-05-01 au 2024-04-30
- The identification of the molecular mechanisms through which neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases - Fondation du CHU de Québec, chercheur principal - 2023-04-17 au 2024-03-31
- Manipulating the neuroimmune response to promote spinal cord repair - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-04-01 au 2024-03-31
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Publications
- A novel method for multiple labeling combining in situ hybridization with immunofluorescence, Lacroix, S., Vallières, N., Barrette, B., Pineau, I., 2006, 10.1369/jhc.6A7022.2006
- The P2X7/P2X4 interaction shapes the purinergic response in murine macrophages, Jorge Arreola, Patricia Pérez-Cornejo, Steve Lacroix, Luis Vaca, Jonathan Pacheco, Sébastien A. Lévesque, Gabriela Pérez-Flores, Biochemical and Biophysical Research Communications, 2015, 10.1016/j.bbrc.2015.10.025
- The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations, Rivest, S., Feinstein, D., Lacroix, S., 1998
- Proinflammatory signal transduction pathways in the CNS during systemic immune response, Laflamme, N., Lacroix, S., Nadeau, S., Rivest, S., 2001, 10.1016/S1567-7443(01)80015-6
- Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1α and interleukin-1β Wallerian degeneration, David, S., Avilés-Trieueros, M., Lacroix, S., Perrin, F.E., 2005, 10.1093/brain/awh407
- T cells contribute to lysophosphatidylcholine-induced macrophage activation and demyelination in the CNS, David, S., Lacroix, S., Suh, Y.J., Ghasemlou, N., 2007, 10.1002/glia.20449
- In Vivo Imaging of Glial and Immune Cell Responses in Central Nervous System Injury and Disease, Lacroix, S., Paré, A., Neuroinflammation: New Insights into Beneficial and Detrimental Functions, 2015, 10.1002/9781118732748.ch2
- Portrait of blood-derived extracellular vesicles in patients with Parkinson's disease., , Neurobiology of disease, 2018, 10.1016/j.nbd.2018.11.002
- Neurotrophic Factors and Gene Therapy in Spinal Cord Injury, Tuszynski, M.H., Lacroix, S., Neurorehabilitation and Neural Repair, 2000, 10.1177/154596830001400403
- Role of cyclo-oxygenase pathways in the stimulatory influence of immune challenge on the transcription of a specific CRF receptor subtype in the rat brain, Rivest, S., Lacroix, S., 1996, 10.1016/0891-0618(95)00106-9
- Megakaryocytes compensate for Kit insufficiency in murine arthritis, Peter A. Nigrovic, Eric Boilard, Joseph E. Italiano, Michael F. Gurish, Jerry Ware, Yoichiro Iwakura, Steve Lacroix, Imene Melki, Mary M. Chen, Margaret H. Chang, Tatiana Jones, Paul A. Monach, Jonathan N. Thon, Loka R. Penke, Pierre Cunin, Journal of Clinical Investigation, 2017, 10.1172/JCI84598
- Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation., , Blood advances, 2019, 10.1182/bloodadvances.2018026732
- Involvement of the IL-1 system in experimental autoimmune encephalomyelitis and multiple sclerosis: Breaking the vicious cycle between IL-1β and GM-CSF, Steve Lacroix, Sébastien A. Lévesque, Benoit Mailhot, Alexandre Paré, Brain, Behavior, and Immunity, 2016, 10.1016/j.bbi.2016.07.146
- Automated Filtering of Intrinsic Movement Artifacts during Two-Photon Intravital Microscopy, Lacroix, S., Coste, J., Paré, A., Soulet, D., 2013, 10.1371/journal.pone.0053942
- Expression profile of receptors for myelin-associated inhibitors of axonal regeneration in the intact and injured mouse central nervous system, Lacroix, S., Dubé, M., Vallières, N., Barrette, B., 2007, 10.1016/j.mcn.2006.12.004
- Constitutive DAMPs in CNS injury: From preclinical insights to clinical perspectives, Steve Lacroix, Dominic Bélanger, Ana Boisvert, Floriane Bretheau, Adrian Castellanos-Molina, Brain, Behavior, and Immunity, 2024, 10.1016/j.bbi.2024.07.047
- Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury., , Nature communications, 2019, 10.1038/s41467-019-08446-0
- GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer’s disease, , Brain, Behavior, and Immunity, 2015, 10.1016/j.bbi.2015.01.010
- Functional circuitry in the brain of immune-challenged rats: Partial involvement of prostaglandins, Rivest, S., Lacroix, S., 1997, 10.1002/(SICI)1096-9861(19971020)387:2<307::AID-CNE11>3.0.CO;2-R
- How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli, Laflamme, N., Zhang, J., Nadeau, S., Vallières, L., Lacroix, S., Rivest, S., 2000
- Mutant huntingtin is present in neuronal grafts in huntington disease patients, Freeman, T.B., Barker, R.A., Mantovani, D., Hauser, R.A., Skepper, J.N., Tolouei, R., St-Amour, I., Saint-Pierre, M., Vallières, N., Cisbani, G., Lacroix, S., Cicchetti, F., Annals of Neurology, 2014, 10.1002/ana.24174
- P2X 4 receptors influence inflammasome activation after spinal cord injury, Lacroix, S., Keane, R.W., De Koninck, Y., Dalton Dietrich, W., Pineau, I., Yurcisin, G., Bastien, D., de Rivero Vaccari, J.P., 2012, 10.1523/JNEUROSCI.4930-11.2012
- IL-1α gene deletion protects oligodendrocytes after spinal cord injury through upregulation of the survival factor Tox3, Lacroix, S., Doyon, Y., Tremblay, M.-È., Takashima, A., Champagne, M., Vallières, N., Lessard, M., Landete, V.B., Bastien, D., Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.0498-15.2015
- Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology, Cicchetti, F., Barker, R.A., Francis, S.T., Gowland, P.A., Lacroix, S., Calon, F., Mason, S.L., St-Amour, I., Alata, W., Dury, R.J., Saint-Pierre, M., Kuan, W.-L., Lagacé, M., Cisbani, G., Sawiak, S.J., Drouin-Ouellet, J., Annals of Neurology, 2015, 10.1002/ana.24406
- Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury, Lacroix, S., Rivest, S., Vallières, N., Filali, M., Barrette, B., Pineau, I., Boivin, A., 2007, 10.1523/JNEUROSCI.3027-07.2007
- Partial depletion of the proinflammatory monocyte population is neuroprotective in the myenteric plexus but not in the basal ganglia in a MPTP mouse model of Parkinson's disease, Soulet, D., Lacroix, S., Jobin, C., Aubé, B., Poirier, A.-A., Côté, M., Brain, Behavior, and Immunity, 2015, 10.1016/j.bbi.2015.01.009
- IL-1β enables CNS access to CCR2 hi monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells, Steve Lacroix, Alyson Fournier, Manu Rangachari, Marc-André Lécuyer, Alexandre Prat, Prenitha Mercy Ignatius Arokia Doss, Camille Juzwik, Sébastien A. Lévesque, Benoit Mailhot, Alexandre Paré, Proceedings of the National Academy of Sciences, 2018, 10.1073/pnas.1714948115
- Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases, Lacroix, S., Côté, D., Prat, A., Engelhardt, B., De Koninck, Y., Alvarez, J.I., Lécuyer, M.-A., Gorina, R., Kébir, H., Chamma, É., Paré, A., Lévesque, S.A., Aubé, B., Journal of Immunology, 2014, 10.4049/jimmunol.1400401
- Calretinin gene expression in the human thalamus, Parent, A., Beach, T.G., Lacroix, S., Cicchetti, F., 1998, 10.1016/S0169-328X(97)00314-8
- Cytokine pathways regulating glial and leukocyte function after spinal cord and peripheral nerve injury, Lacroix, S., Bastien, D., Experimental Neurology, 2014, 10.1016/j.expneurol.2014.04.006
- Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions, Fernandes, K.J.L., Grégoire, C.-A., Lévesque, S.A., Pineau, I., Breault-Dugas, C., Beaudoin, S., Vaugeois, A., Hamilton, L.K., Lacroix, S., 2014, 10.1371/journal.pone.0085916
- Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain, Rivest, S., Lacroix, S., 1998
- The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis, Vallières, L., Lacroix, S., Keane, R.W., Chae, J.J., de Rivero Vaccari, J.P., Amiable, N., Dumas, A., PLoS Pathogens, 2014, 10.1371/journal.ppat.1004150
- An essential role of interleukin-1β in mediating NF-κB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia, Rivest, S., Lacroix, S., Laflamme, N., 1999
- Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth, Tuszynski, M.H., Rose-John, S., Chang, L., Lacroix, S., 2002, 10.1002/cne.10407
- Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion, Lacroix, S., Bastien, D., Sun, L., Pineau, I., 2010, 10.1016/j.bbi.2009.11.007
- Molecular approaches to spinal cord repair, Lacroix, S., David, S., 2003, 10.1146/annurev.neuro.26.043002.094946
- NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection, Lu, P., Lacroix, S., Löw, K., Blesch, A., Brant, A., Jones, L.L., Grill, R., Tuszynski, M.H., 2003, 10.1016/S0014-4886(02)00055-9
- Myeloid cell transmigration across the CNS vasculature triggers IL-1ß-driven neuroinflammation during autoimmune encephalomyelitis in mice, Lacroix, S., Keane, R.W., de Rivero Vaccari, J.P., Prat, A., Alvarez, J.I., Lécuyer, M.-A., Kébir, H., Bellver-Landete, V., Mailhot, B., Paré, A., Lévesque, S.A., Journal of Experimental Medicine, 2016, 10.1084/jem.20151437
- Endogenous signals initiating inflammation in the injured nervous system, Lacroix, S., Pineau, I., 2009, 10.1002/glia.20763
- Transcriptional profiling of the injured sciatic nerve of mice carrying the Wld(S) mutant gene: Identification of genes involved in neuroprotection, neuroinflammation, and nerve regeneration, Lacroix, S., Vallières, N., Calvo, E., Barrette, B., 2010, 10.1016/j.bbi.2010.07.249
- Ly6C high monocytes facilitate transport of Murid herpesvirus 68 into inflamed joints of arthritic mice, Gosselin, J., Brown, J.P., Lacroix, S., Paré, A., Lacerte, P., Brunet, A., Egarnes, B., LeBel, M., European Journal of Immunology, 2018, 10.1002/eji.201747048
- C-fos mRNA pattern and corticotropin-releasing factor neuronal activity throughout the brain of rats injected centrally with a prostaglandin of E2 type, Rivest, S., Vallières, L., Lacroix, S., 1996, 10.1016/S0165-5728(96)00114-2
- Betacellulin regulates schwann cell proliferation and myelin formation in the injured mouse peripheral nerve., , Glia, 2017, 10.1002/glia.23119
- Platelets can enhance vascular permeability, Boilard, E., Lacroix, S., Nigrovic, P.A., Schumacher, H.R., Farndale, R.W., Paré, A., Cloutier, N., 2012, 10.1182/blood-2012-02-413047
- Systemic injections of lipopolysaccharide accelerates myelin phagocytosis during wallerian degeneration in the injured mouse spinal cord, Lacroix, S., David, S., Berard, J.L., Vallières, N., 2006, 10.1002/glia.20266
- The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury, Steve Lacroix, Ning Quan, Xiaoyu Liu, Nicolas Vallières, Martine Lessard, Dominic Belanger, Maxime Kusik, Benoit Mailhot, Adrian Castellanos-Molina, Floriane Bretheau, 2021, 10.21203/rs.3.rs-580331/v1
- Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved, Lacroix, S., Pineau, I., 2007, 10.1002/cne.21149
- Bilateral Corticospinal Projections Arise from Each Motor Cortex in the Macaque Monkey: A Quantitative Study, Tuszynski, M.H., Roberts, J., Brant, A., Yang, H., McKay, H., Havton, L.A., Lacroix, S., 2004, 10.1002/cne.20051
- Influence of cytokines on neuroendocrine functions during immune response: Mechanisms and neuronal circuitry involved,INFLUENCE DES CYTOKINES SUR LES FONCTIONS NEUROENDOCRINIENNES DURANT LA REPONSE IMMUNITAIRE: MECANISMES IMPLIQUES ET VOIES NEURONALES EMPRUNTEES, Lacroix, S., Rivest, S., Annales d'Endocrinologie, 1995
- In situ hybridization within the CNS tissue: Combining in situ hybridization with immunofluorescence, Lacroix, S., Bastien, D., Neuromethods, 2012, 10.1007/978-1-61779-897-9_3
- Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration., , Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1720553115
- Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: Implications for neuropathic pain, Lacroix, S., Keane, R.W., Vaccari, J.P.R., Iwakura, Y., Soulet, D., Rivest, S., Kerr, B.J., Zhang, J., Filali, M., Nadeau, S., 2011, 10.1523/JNEUROSCI.2840-11.2011
- Local assessment of myelin health in a multiple sclerosis mouse model using a 2D Fourier transform approach, Côté, D., De Koninck, Y., Lacroix, S., Bélisle, J., Chamma, É., Aubé, B., Laffray, S., Bélanger, E., Bégin, S., 2013, 10.1364/BOE.4.002003
- Requirement of myeloid cells for axon regeneration, Lacroix, S., Julien, J.-P., Gowing, G., Vallières, N., Lafortune, K., Filali, M., Hébert, M.-A., Barrette, B., 2008, 10.1523/JNEUROSCI.1447-08.2008
- Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase a to promote inflammation, Boilard, E., Gelb, M.H., Semple, J.W., Thibault, L., Lacroix, S., Guderley, H., Nigrovic, P.A., Garraud, O., Cognasse, F., Hamzeh-Cognasse, H., Pouliot, M., Farndale, R.W., Lambeau, G., Marcoux, G., Laflamme, C., Lévesque, T., Naika, G.S., Rousseau, M., Paré, A., Bollinger, J., Martin, N., Soulet, D., Cloutier, N., Duchez, A.-C., Boudreau, L.H., Blood, 2014, 10.1182/blood-2014-05-573543
- Influence of lnterleukin-6 on neural activity and transcription of the gene encoding corticotrophin-releasing factor in the rat brain: An effect depending upon the route of administration, Rivest, S., Lacroix, S., Vallières, L., 1997, 10.1111/j.1460-9568.1997.tb01500.x
- FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential., , Experimental cell research, 2018, 10.1016/j.yexcr.2018.04.017
- Serial Systemic Injections of Endotoxin (LPS) Elicit Neuroprotective Spinal Cord Microglia through IL-1-Dependent Cross Talk with Endothelial Cells, Phillip G. Popovich, Ning Quan, Steve Lacroix, Xiaoyu Liu, Daniel P. Nemeth, Kristina A. Kigerl, Jodie C. Hall, Zhen Guan, David R. Sweet, Faith H. Brennan, Camila M. Freria, The Journal of Neuroscience, 2020, 10.1523/JNEUROSCI.0131-20.2020
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2020/07- Maxime Kusik - Doctorat - En cours
- Dominic Bélanger - Maîtrise avec mémoire - En cours
- Camille Cassandre Illiano - Doctorat - En cours
- Ana Boisvert - Doctorat - En cours
- Juliette Ferry - Doctorat - En cours
- Adrian Castellanos Molina - Doctorat - En cours
- Floriane Bretheau - Doctorat - 2021/01
- Benoit Mailhot - Doctorat - 2021/05
- Felipe Da Gama Monteiro - Doctorat - 2025/01
Encadrement d'étudiant(e)s
Direction de recherche dans les domaines suivants :
- Médecine moléculaire
- Neurobiologie — Neurosciences
En savoir plus sur les programmes
Disponibilité d'encadrement d'étudiant(e)s
Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.
Envoyer un courriel*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.