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Sylvain-Georges Bourgoin

Professeur titulaire

Sylvain-Georges Bourgoin
sylvain-georges.bourgoin@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Maladies infectieuses et immunitaires
  • Leucocytes
  • Maladies auto-immunes
  • Médiateurs immunologiques : cytokines et chimiokines
Appareil locomoteur et arthrite
  • Arthrite/arthrose

Projets de recherche

  • Metabolic mechanisms of pro-resolutive neutrophils in chronic inflammatory diseases - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-04-01 au 2029-03-31
  • Role of phosphatidylserine-specific phospholipase A1 (PLA1A) in the pathogenesis of rheumatic diseases - La société d'arthrite - Subvention stratégique de fonctionnement, chercheur principal - 2023-01-01 au 2025-12-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Role of lyso-phosphatidylserine generated by phosphatidylserine-specific phospholipase A1 (PLA1A) in the pathogenesis of rheumatic diseases - CHU de Québec – Université Laval – CHUL - Aide à la recherche, chercheur principal - 2021-11-01 au 2022-10-31
  • Role of autotaxin bound to platelet-derived microparticles to development of vascular damage in arthritis. - Instituts de recherche en santé du Canada - Subvention de fonctionnement, chercheur principal - 2015-07-01 au 2021-06-30

Publications

  • Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: Involvement of cPLA2α and reversal by lyso-PAF, Borgeat, P., Bourgoin, S.G., Lemieux, L., Picard, S., Lapointe, G., Lefebvre, J., Flamand, N., Journal of Leukocyte Biology, 2006, 10.1189/jlb.1005614
  • Interference of HIV-1 Nef in the sphingomyelin transduction pathway activated by tumour necrosis factor-α in human glial cells, Poulin, L., Darveau, A., Bourgoin, S., Lapointe, R., Robichaud, G., Richard, A., AIDS, 1997, 10.1097/00002030-199701000-00001
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes human neutrophils for enhanced phosphatidylcholine breakdown by phospholipase D, Poubelle, P.E., Borgeat, P., Bourgoin, S., Agents and Actions, 1991, 10.1007/BF01993230
  • V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway, Marshansky, V., Brown, D., Ausiello, D.A., Bechoua, S., Wildeman, A., Casanova, J., Bourgoin, S., Sun-Wada, G.-H., Futai, M., El Annan, J., Skinner, M., Hurtado-Lorenzo, A., Nature Cell Biology, 2006, 10.1038/ncb1348
  • Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts, Bourgoin, S.G., Touaibia, M., Fernandes, M.J., Di Battista, J.A., Moreno-Nieves, U., Zhao, C., Mediators of Inflammation, 2015, 10.1155/2015/436525
  • Characterization of cytohesin-1 monoclonal antibodies: Expression in neutrophils and during granulocytic maturation of HL-60 cells, Bourgoin, S.G., Naccache, P.H., Harbour, D., Gagnon, S., Chouinard, F., Houle, M.G., Garceau, V., Journal of Immunological Methods, 2001, 10.1016/S0022-1759(00)00336-7
  • Suppressive effects of adenosine on the 5-lipoxygenase pathway in human polymorphonuclear leukocytes, Borgeat, P., Bourgoin, S., Krump, E., Surette, M.E., Austin, M., Picard, S., Plante, H., Flamand, N., Drug Development Research, 2001, 10.1002/ddr.1140
  • Studies on the effects of disease-modifying antirheumatic drugs on lipoxygenase product synthesis in human neutrophils in vitro, Borgeat, P., Beaulieu, A.D., Marceau, F., Bourgoin, S., Poubelle, P.E., International Journal of Immunopharmacology, 1988, 10.1016/0192-0561(88)90024-0
  • Interactions of SIN-1 with the generation of cyclic nucleotides and arachidonate metabolites in the uterine smooth muscle,INTERACTIONS DU SIN-1 AVEC LA GENERATION DES NUCLEOTIDES CYCLIQUES ET DES METABOLITES OXYDES DE L'ARACHIDONATE DANS LE MUSCLE UTERIN, Harbon, S., Leiber, D., Bourgoin, S., Pathologie Biologie, 1987
  • Crystal-induced neutrophil activation VI. Involvement of FcγRIIIB (CD16) and CD11b in response to inflammatory microcrystals, Naccache, P.H., Bourgoin, S.G., Liao, N., Gilbert, C., Barabé, F., FASEB Journal, 1998
  • The PGE2-induced inhibition of the PLD activation pathway stimulated by fMLP in human neutrophils is mediated by PKA at the PI3-Kγ level, Bourgoin, S.G., Naccache, P.H., Harbour, D., Thibault, N., Burelout, C., Biochemical Pharmacology, 2007, 10.1016/j.bcp.2007.06.013
  • Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): Priming of human neutrophils in vitro with GM-CSF Is associated with accumulation of phosphatidic acid and diradylglycerol, Poubelle, P.E., Borgeat, P., Naccache, P.H., Gaudry, M., Plante, E., Bourgoin, S., Journal of Experimental Medicine, 1990, 10.1084/jem.172.3.767
  • Role of protein kinase Cα, Arf, and cytoplasmic calcium transients in phospholipase D activation by sodium fluoride in osteoblast-like cells, Poubelle, P.E., Harbour, D., Bourgoin, S.G., Journal of Bone and Mineral Research, 1996
  • ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat, Hsu, V.W., Premont, R.T., Randazzo, P.A., Bourgoin, S., Gao, M., Lee, S.Y., Yang, J.-S., Journal of Cell Biology, 2002, 10.1083/jcb.200206015
  • Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils, Borgeat, P., Bourgoin, S.G., Pouliot, M., Lemieux, L., Picard, S., Flamand, N., British Journal of Pharmacology, 2006, 10.1038/sj.bjp.0706879
  • Peroxides of vanadate induce activation of phospholipase D in HL-60 cells: Role of tyrosine phosphorylation, Grinstein, S., Bourgoin, S., Journal of Biological Chemistry, 1992
  • C2-ceramide primes specifically for the superoxide anion production induced by N-formylmethionylleucyl phenylalanine (fMLP) in human neutrophils, Pelletier, G., McColl, S.R., Krump, E., L'Heureux, G.P., Naccache, P.H., Bourgoin, S., Richard, A., Biochimica et Biophysica Acta - Lipids and Lipid Metabolism, 1996, 10.1016/0005-2760(95)00215-4
  • Subcellular distribution and characterization of rat pancreatic phospholipase D isoforms, Morisset, J., Bourassa, J., Bourgoin, S., Lainé, J., Pancreas, 2000, 10.1097/00006676-200005000-00001
  • Small GTPase-regulated phospholipase D in granulocytes, Bourgoin, S., Houle, M.G., Biochemistry and Cell Biology, 1996, 10.1139/o96-050
  • A phosphorylatable sphingosine analog induces airway smooth muscle cytostasis and reverses airway hyperresponsiveness in experimental asthma, Marsolais, D., Bossé, Y., Bourgoin, S.G., Laplante, M., Blanchet, M.-R., Bissonnette, É., Don, A.S., Flamand, N., Lee-Gosselin, A., Huppé, C.-A., Beaulieu, M.-J., Lemay, A.-M., Lecours, P.B., Gendron, D.R., Frontiers in Pharmacology, 2017, 10.3389/fphar.2017.00078
  • Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis, Kusner, D.J., Bourgoin, S., Barton, J.A., Iyer, S.S., Journal of Immunology, 2004, 10.4049/jimmunol.173.4.2615
  • Metabolic regulation of neutrophil functions in homeostasis and diseases, Martin Pelletier, Philippe A Tessier, Patrice E Poubelle, Sylvain G Bourgoin, Pier-Olivier Leblanc, Journal of Leukocyte Biology, 2024, 10.1093/jleuko/qiae025
  • Granulocyte-macrophage colony-stimulating factor primes phospholipase D activity in human nerutrophils in vitro: Role of calcium, G-proteins and tyrosine kinases, Naccache, P.H., Borgeat, P., Emezawa, K., Liao, N.W., Poubelle, P.E., Bougoin, S., Cellular Signalling, 1992, 10.1016/0898-6568(92)90018-4
  • Phospholipase A1 Member A Deficiency Alleviates Mannan-Induced Psoriatic Arthritis in Mice Model, Sylvain G. Bourgoin, Fawzi Aoudjit, Yang Zhao, International Journal of Molecular Sciences, 2022, 10.3390/ijms23158559
  • Crystal-induced neutrophil activation. VII. Involvement of Syk in the responses to monosodium urate crystals, Naccache, P.H., Bourgoin, S.G., Gilbert, C., Fernandes, M., Desaulniers, P., Journal of Leukocyte Biology, 2001
  • Automated on-line extraction and profiling of lipoxygenase products of arachidonic acid by high-performance liquid chromatography, Epoubelle, P., Sirois, P., Odeimat, A., Bourgoin, S., Vallerand, P., Picard, S., Borgeat, P., Methods in Enzymology, 1990, 10.1016/0076-6879(90)87014-T
  • Tumor necrosis factor-α induces stress fiber formation through ceramide production: Role of sphingosine kinase, Brindley, D.N., Bourgoin, S., Begg, D., Kikuchi, Y., Berthiaume, L.G., Hanna, A.N., Molecular Biology of the Cell, 2001, 10.1091/mbc.12.11.3618
  • ARNO but not cytohesin-1 translocation is phosphatidylinositol 3-kinase-dependent in HL-60 cells, Brindley, D.N., Morris, A.J., Gagnon, S., Harbour, D., Singh, I.N., Houle, M.G., Bourgoin, S.G., Journal of Leukocyte Biology, 2002
  • A transgenic mouse model for the in vivo bioluminescence imaging of the expression of the lysophosphatidic acid receptor 3: relevance for inflammation and uterine physiology research, Maria J. Fernandes, Sylvain G. Bourgoin, Patrice E. Poubelle, Lynn Davis, Anne Sardella, Chenqi Zhao, Sylvain Bourgoin, Transgenic Research, 2015, 10.1007/s11248-015-9882-8
  • Phospholipase D2 in prostate cancer: protein expression changes with Gleason score, Martin G. Rumsby, Norman J. Maitland, Sylvain Bourgoin, Daniel M. Berney, Rakesh Suman, Karen Hogg, Amanda R. Noble, Sylvain Bourgoin, British Journal of Cancer, 2019, 10.1038/s41416-019-0610-7
  • Altered formation of leukotriene B4in vitro by synovial fluid neutrophils in rheumatoid arthritis, Borgeat, P., Beaulieu, A.D., Nguyen, M.-H., McColl, S.R., Bourgoin, S., Poubelle, P.E., Journal of Rheumatology, 1989
  • GLUT-4 translocation in skeletal muscle studied with a cell-free assay: Involvement of phospholipase D, Richter, E.A., Franco, M., Klip, A., Bourgoin, S., Nielsen, J.N., Kristiansen, S., American Journal of Physiology - Endocrinology and Metabolism, 2001
  • TNF-α promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines, Bourgoin, S.G., Fernandes, M.J., Poubelle, P.E., Chun, J., Sardella, A., Zhao, C., Journal of Lipid Research, 2011, 10.1194/jlr.M008045
  • Protein kinase Cζ regulates phospholipase D activity in rat-1 fibroblasts expressing the α1A adrenergic receptor, Malik, K.U., Bourgoin, S.G., Saeed, A.E., Wiggins, M.T., Gandhi, G.K., Parmentier, J.-H., BMC Cell Biology, 2004, 10.1186/1471-2121-5-4
  • Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: Impact of TNF-α, Bourgoin, S.G., Poubelle, P.E., Di Battista, J., Tancrède, S., Turgeon, M., Fernandes, M.J., Zhao, C., Journal of Lipid Research, 2008, 10.1194/jlr.M800143-JLR200
  • Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T cells·AP-1 activation through regulation of the JNK pathway, Gadina, M., Bourgoin, S.G., Coffey, A., Chen, Q., Journal of Biological Chemistry, 2006, 10.1074/jbc.M601629200
  • Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils, Borgeat, P., Bourgoin, S., Picard, S., Surette, M.E., Flamand, N., Molecular Pharmacology, 2002, 10.1124/mol.62.2.250
  • Prostaglandin G/H synthase (PGHS)-2 expression in bovine myometrium: Influence of steroid hormones and PGHS inhibitors, Fortier, M.A., Bourgoin, S., Guay, J.M., Doualla-Bell, F., Biology of Reproduction, 1998, 10.1095/biolreprod59.6.1433
  • Cholesterol-modulating agents selectively inhibit calcium influx induced by chemoattractants in human neutrophils, Naccache, P.H., Bourgoin, S.G., Fernandes, M.J.G., Paré, G., Barabé, F., Journal of Biological Chemistry, 2002, 10.1074/jbc.M112149200
  • LPA promotes T cell recruitment through synthesis of CXCL13, Bourgoin, S.G., Zhao, C., Hui, W., Mediators of Inflammation, 2015, 10.1155/2015/248492
  • Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes, Bourgoin, S.G., Poubelle, P.E., Fernandes, M.J., Hui, W., Zhao, C., Biochemical Pharmacology, 2014, 10.1016/j.bcp.2014.04.012
  • Functional Role of AGAP2/PIKE-A in Fcγ Receptor-Mediated Phagocytosis, Sylvain G. Bourgoin, Caroline Gilbert, Lynn Davis, François C. Chouinard, Cells, 2022, 10.3390/cells12010072
  • Red blood cell-derived phosphatidylserine positive extracellular vesicles are associated with past thrombotic events in patients with systemic erythematous lupus, Sylvain G Bourgoin, Paul R Fortin, Eric Boilard, Chenqi Zhao, Anne-Claire Duchez, Anne-Sophie Julien, Stephan Hasse, Lupus Science & Medicine, 2022, 10.1136/lupus-2021-000605
  • Agonist-specific tyrosine phosphorylation of Cbl in human neutrophils, Bourgoin, S.G., Mahana, W., Al-Shami, A., Barabé, F., Gilbert, C., Naccache, P.H., Journal of Leukocyte Biology, 1997, 10.1002/jlb.62.6.901
  • Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases, Bourgoin, S.G., Naccache, P.H., Borgeat, P., Harbour, D., Thibault, N., Blood, 2000
  • Interplay between LPA2 and LPA3 in LPA-mediated phosphatidylserine cell surface exposure and extracellular vesicles release by erythrocytes, Sylvain G. Bourgoin, Eric Boilard, Paul Fortin, Anne-Claire Duchez, Stephan Hasse, Sylvain Bourgoin, Biochemical Pharmacology, 2021, 10.1016/j.bcp.2021.114667
  • Effect of molsidomine derivative (SIN-1) on leukotriene synthesis in human leukocytes,EFFET DU SIN-1 SUR LA SYNTHESE DE LEUCOTRIENES DANS LES POLYMORPHONUCLEAIRES HUMAINS, Borgeat, P., Poubelle, P., Bourgoin, S., Pathologie Biologie, 1987
  • Lipoxygenase and cyclooxygenase products of arachidonic acid in uterus. Selective interaction with the cGMP and cAMP systems, Harbon, S., Leiber, D., Bourgoin, S., Vesin, M.F., Prostaglandins, Leukotrienes and Medicine, 1984, 10.1016/0262-1746(84)90105-7
  • Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise, Sylvain G. Bourgoin, Stephan Hasse, Yang Zhao, Sylvain Bourgoin, Progress in Lipid Research, 2021, 10.1016/j.plipres.2021.101112
  • Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: Regulation by phosphatidylinositol 3-kinase and cytohesin-1, Hmama, Z., Talal, A., Bourgoin, S., Lee, J.S.I., Reiner, N.E., Sendide, K., Journal of Immunology, 2005, 10.4049/jimmunol.174.7.4210
  • A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance, Hsu, V.W., Luini, A., Frohman, M.A., Bourgoin, S., Graziani, A., Baldanzi, G., Du, G., Bonsra, A.N., Turacchio, G., Valente, C., Beznoussenko, G.V., Zhang, L., Mironov, A., Lee, S.Y., Gad, H., Yang, J.-S., Nature Cell Biology, 2008, 10.1038/ncb1774
  • Expression and activity of prostaglandin endoperoxide synthase-2 in agonist-activated human neutrophils, Naccache, P.H., McColl, S.R., Maclouf, J., Créminon, C., Bourgoin, S., Poubelle, P.E., Borgeat, P., Gilbert, C., Pouliot, M., FASEB Journal, 1998
  • Receptor-mediated endocytosis in kidney proximal tubules: Recent advances and hypothesis, Vinay, P., Maranda, B., Bendayan, M., Londoño, I., Bourgoin, S., Marshansky, V., Electrophoresis, 1997, 10.1002/elps.1150181423
  • Activation of phospholipase D by bradykinin and sphingosine 1-phosphate in A549 human lung adenocarcinoma cells via different GTP-binding proteins and protein kinase C delta signaling pathways, Vaughan, M., Moss, J., Bruni, P., Bourgoin, S., Donati, C., Vasta, V., Catarzi, S., Nuti, F., Meacci, E., Biochemistry, 2003, 10.1021/bi026350a
  • Human phospholipase D1 can be tyrosine-phosphorylated in HL-60 granulocytes, Bourgoin, S., Naccache, P.H., Harbour, D., Marcil, J., Journal of Biological Chemistry, 1997, 10.1074/jbc.272.33.20660
  • Stimulation of human neutrophils by chemotactic factors is associated with the activation of phosphatidylinositol 3-kinase γ, McColl, S.R., Bourgoini, S.G., Chakravarti, S., Lachance, G., Levasseur, S., Naccache, P.H., Journal of Biological Chemistry, 2000, 10.1074/jbc.M001780200
  • Cytohesin-1 regulates fMLF-mediated activation and functions of the β2integrin Mac-1 in human neutrophils, Bourgoin, S.G., Garceau, V., el Azreq, M.-A., Journal of Leukocyte Biology, 2011, 10.1189/jlb.0410222
  • Differential expression of adenosine receptors in human neutrophils: Up-regulation by specific Th1 cytokines and lipopolysaccharide, Bourgoin, S., Borgeat, P., Fernandes, M., Harbour, D., Fortin, A., Journal of Leukocyte Biology, 2006, 10.1189/jlb.0505249
  • Expression and distribution of adenosine diphosphate-ribosylation factors in the rat kidney, Bendayan, M., Vinay, P., Bourgoin, S., Marshansky, V., Londono, I., Kidney International, 1999, 10.1046/j.1523-1755.1999.00365.x
  • Occupancy of adenosine A2a receptors promotes fMLP-induced cyclic AMP accumulation in human neutrophils: Impact on phospholipase D activity and recruitment of small GTPases to membranes, Bourgoin, S.G., Naccache, P.H., Borgeat, P., Harbour, D., Burelout, C., Thibault, N., Journal of Leukocyte Biology, 2002
  • Identification of ADP-ribosylation factor-6 in brushborder membrane and early endosomes of human kidney proximal tubules, Bendayan, M., Vinay, P., Londoño, I., Bourgoin, S., Marshansky, V., Electrophoresis, 1997, 10.1002/elps.1150180334
  • Prostaglandin E2inhibits the phospholipase D pathway stimulated by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Involvement of EP2receptors and phosphatidylinositol 3-kinase γ, Bourgoin, S.G., Simard, S., Naccache, P.H., Thibault, N., Levasseur, S., Burelout, C., Molecular Pharmacology, 2004, 10.1124/mol.66.2.293
  • Arf6 regulates energy metabolism in neutrophils, Sylvain Bourgoin, Martin Pelletier, Fawzi Aoudji, Yasunori Kanaho, Yuji Funakoshi, Tsunaki Hongu, Chenqi Zhao, Emmanuelle Rollet-Labelle, Nathalie Pagé, Andrew Z. Leong, Lynn Davis, Jouda Gamara, Free Radical Biology and Medicine, 2021, 10.1016/j.freeradbiomed.2021.07.001
  • Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules, Eric Boilard, Benoît Vingert, Mélanie Dieudé, Bogdan Iulius Florea, Herman S. Overkleeft, France Pirenne, Marie-Josée Hébert, John Semple, Rick Kapur, Fabrice Cognasse, HAMZEH-COGNASSE, Sylvain Bourgoin, Julie Turgeon, Annie Karakeussian Rimbaud, Johan Rebetz, Tania Lévesque, Anne Zufferey, Isabelle Allaeys, Marie Tamagne, Maroua Mbarik, Marie Bellio, Stephan Hasse, Audrée Laroche, Genevieve Marcoux, Blood, 2021, 10.1182/blood.2020009957
  • Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion?, Sylvain G. Bourgoin, Maria J. Fernandes, John A. Di Battista, Melissa Laflamme, David Marsolais, Nathalie Amiable, Chenqi Zhao, Biochemical Pharmacology, 2019, 10.1016/j.bcp.2019.02.009
  • Dissociation between the translocation and the activation of Akt in fMLP-stimulated human neutrophils - Effect of prostaglandin E2, Bourgoin, S.G., Naccache, P.H., Burelout, C., Journal of Leukocyte Biology, 2007, 10.1189/jlb.0406256
  • Assessment of Arf6 Deletion in PLB-985 Differentiated in Neutrophil-Like Cells and in Mouse Neutrophils: Impact on Adhesion and Migration, Sylvain G. Bourgoin, Fawzi Aoudjit, Yasunori Kanaho, Yuji Funakoshi, Tsunaki Hongu, Emmanuelle Rollet-Labelle, Lynn Davis, Jouda Gamara, Mediators of Inflammation, 2020, 10.1155/2020/2713074
  • Phospholipase A1 Member A Activates Fibroblast-like Synoviocytes through the Autotaxin-Lysophosphatidic Acid Receptor Axis, Sylvain G. Bourgoin, Patrice E. Poubelle, John Di Battista, Paul Fortin, Eric Boilard, Lynn Davis, Chenqi Zhao, Myriam Vaillancourt, Stephan Hasse, Yang Zhao, Sylvain Bourgoin, International Journal of Molecular Sciences, 2021, 10.3390/ijms222312685
  • Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: Impact on superoxide anion production and secretion, Bourgoin, S.G., Pivot-Pajot, C., Harbour, D., Garceau, V., El Azreq, M.-A., Journal of Immunology, 2010, 10.4049/jimmunol.0901654
  • Munc13-4 regulates granule secretion in human neutrophils, Bourgoin, S.G., De Saint Basile, G., Varoqueaux, F., Pivot-Pajot, C., Journal of Immunology, 2008, 10.4049/jimmunol.180.10.6786
  • Intracellular localization of phospholipase D1 in mammalian cells, Shields, D., Frohman, M., Bourgoin, S., Siddhanta, A., Sweeney, D., Freyberg, Z., Molecular Biology of the Cell, 2001, 10.1091/mbc.12.4.943
  • Monosodium urate-crystal-stimulated phospholipase D in human neutrophils, Bourgoin, S., Naccache, P.H., Houle, M.G., Harbour, D., Marcil, J., Biochemical Journal, 1999, 10.1042/0264-6021:3370185
  • Isolation of heavy endosomes from dog proximal tubules in suspension, Vinay, P., Bourgoin, S., Noël, J., Fleser, A., Marshansky, V., Journal of Membrane Biology, 1996, 10.1007/s002329900110
  • Autotaxin and lysophospholipids in rheumatoid arthritis, Zhao, C., Bourgoin, S.G., Current Opinion in Investigational Drugs, 2010
  • An essential role for phospholipase D in the recruitment of vesicle amine transport protein-1 to membranes in human neutrophils, Bourgoin, S.G., El azreq, M.-A., Harbour, D., Chouinard, F.C., Faugaret, D., Biochemical Pharmacology, 2011, 10.1016/j.bcp.2010.09.014
  • The role of serotonin and other neuroactive molecules in the physiopathogenesis of migraine: Current hypotheses,Implications de la serotonine et d'autres molecules neuroactives dans la physiopathogenie de la migraine. Hypotheses actuelles, Bourgoin, S., Hamon, M., Pathologie Biologie, 2000
  • Phospholipase D2 is localized to the rims of the Golgi apparatus in mammalian cells, Shields, D., Bourgoin, S., Freyberg, Z., Molecular Biology of the Cell, 2002, 10.1091/mbc.02-04-0059
  • Characterisation of degranulation and phagocytic capacity of a human neutrophilic cellular model, PLB-985 cells, Bourgoin, S.G., Harbour, D., Amine El Azreq, M., Chouinard, F.C., Pivot-Pajot, C., Immunobiology, 2010, 10.1016/j.imbio.2009.01.007
  • Tyrosine kinase-regulated small GTPase translocation and the activation of phospholipase D in HL60 granulocytes, Bourgoin, S., Naccache, P.H., Houle, M.G., Journal of Leukocyte Biology, 1999, 10.1002/jlb.66.6.1021
  • Regulation of phospholipase D by phosphorylation-dependent mechanisms, Bourgoin, S., Houle, M.G., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1999, 10.1016/S1388-1981(99)00090-6
  • EFA6, Exchange Factor for ARF6, Regulates the Actin Cytoskeleton and Associated Tight Junction in Response to E-Cadherin Engagement, Chardin, P., Franco, M., Bourgoin, S., Le Bivic, A., Chauvin, J.-P., Klein, S., Luton, F., Molecular Biology of the Cell, 2004, 10.1091/mbc.E03-10-0751
  • The mechanism of docosahexaenoic acid-induced phospholipase D activation in human lymphocytes involves exclusion of the enzyme from lipid rafts, Prigent, A.-F., Némoz, G., Lagarde, M., Bourgoin, S., Sette, C., Agostino, D.S., Dubois, M., Berquand, A., Diaz, O., Journal of Biological Chemistry, 2002, 10.1074/jbc.M202376200
  • ADP-ribosylation factor translocation correlates with potentiation of GTPγS-stimulated phospholipase D activity in membrane fractions of HL-60 cells, Bourgoin, S., Naccache, P.H., Kahn, R.A., Houle, M.G., Journal of Biological Chemistry, 1995, 10.1074/jbc.270.39.22795
  • Low molecular weight GTP-binding proteins in HL-60 granulocytes. Assessment of the role of ARF and of a 50-kDa cytosolic protein in phospholipase D activation, Beaulieu, A., Takai, Y., Desmarais, Y., Harbour, D., Bourgoin, S., Journal of Biological Chemistry, 1995, 10.1074/jbc.270.7.3172
  • Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4and inhibition by adenosine A2Areceptor engagement, Bourgoin, S.G., Borgeat, P., Naccache, P.H., Pelletier, J., Flamand, N., Grenier, S., Journal of Leukocyte Biology, 2003, 10.1189/jlb.0702371
  • Differential effects of inhibitor combinations on Lysophosphatidic acid-mediated chemokine secretion in unprimed and tumor necrosis Factor-α-primed synovial fibroblasts, Bourgoin, S.G., Zhao, C., Hui, W., Frontiers in Pharmacology, 2017, 10.3389/fphar.2017.00848
  • Regulation of Constitutive Protein Transit by Phospholipase D in HT29-cl19A Cells, Raymond, M.-N., Frohman, M.A., Bourgoin, S., Min, D.S., Geny, B., Robin, P., Honkavaara, P., Phebidias, C., Denmat-Ouisse, L.-A., Journal of Biological Chemistry, 2001, 10.1074/jbc.M104276200
  • Evidence for a role for SAM68 in the responses of human neutrophils to ligation of CD32 and to monosodium urate crystals, Naccache, P.H., Damaj, B.B., McColl, S.R., Bourgoin, S.G., Rollet-Labelle, E., Barabé, F., Gilbert, C., Journal of Immunology, 2001, 10.4049/jimmunol.166.7.4664
  • Regulators and Effectors of Arf GTPases in Neutrophils, Bourgoin, S.G., Aoudjit, F., Davis, L., Chouinard, F., Gamara, J., Journal of Immunology Research, 2015, 10.1155/2015/235170
  • Priming of calcium mobilization in human neutrophils by granulocyte-macrophage colony-stimulating factor: Evidence for an involvement of phospholipase D-derived phosphatidic acid, Bourgoin, S., Gaudry, M., Hamelin, B., Naccache, P.H., Cellular Signalling, 1991, 10.1016/0898-6568(91)90040-2
  • Intra-endosomal pH-sensitive Recruitment of the Arf-nucleotide Exchange Factor ARNO and Arf6 from Cytoplasm to Proximal Tubule Endosomes, Marshansky, V., Ausiello, D.A., Vinay, P., Casanova, J.E., Bourgoin, S., Brown, D., Maranda, B., Journal of Biological Chemistry, 2001, 10.1074/jbc.M011577200
  • The characterization of phospholipase D in FRTL-5 thyroid cells, Ginsberg, J., Brindley, D.N., Bourgoin, S., Singh, I., Das, S., Devlin, M.A., Molecular and Cellular Endocrinology, 2000, 10.1016/S0303-7207(00)00299-9
  • Phospholipase D in rat myometrium: Occurrence of a membrane-bound ARF6 (ADP-ribosylation factor 6)-regulated activity controlled by βγ subunits of heterotrimeric G-proteins, Harbon, S., Bader, M.-F., Bourgoin, S., Dokhac, L., Le Stunff, H., Biochemical Journal, 2000, 10.1042/0264-6021:3520491
  • Caspase cleavage of phospholipase D1 in vitro alters its regulation and reveals a novel property of the "loop" region, Shields, D., Bourgoin, S., Riebeling, C., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2008, 10.1016/j.bbalip.2008.05.007
  • Identification of an autoantigen on the surface of apoptotic human T cells as a new protein interacting with inflammatory group IIA phospholipase A 2, Surette, M.E., Bernatchez, C., Bourgoin, S.G., Boilard, E., Blood, 2003, 10.1182/blood-2002-12-3702
  • Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. II. Effects of LFM-A13, a specific Btk inhibitor, Naccache, P.H., Bourgoin, S.G., Thibault, N., Dusseault, A.-A., Desaulniers, P., Levasseur, S., Gilbert, C., Journal of Immunology, 2003, 10.4049/jimmunol.170.10.5235
  • Human Inflammatory Neutrophils Express Genes Encoding Peptidase Inhibitors: Production of Elafin Mediated by NF-κB and CCAAT/Enhancer-Binding Protein β, Patrice E. Poubelle, Sylvain G. Bourgoin, Flavia Ribeiro de Vargas, Isabelle Allaeys, The Journal of Immunology, 2021, 10.4049/jimmunol.2000852
  • Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ, Marshansky, V., Ausiello, D.A., Bourgoin, S., Breton, S., Brown, D., El Annan, J., American Journal of Physiology - Cell Physiology, 2004
  • Targeting the autotaxin – Lysophosphatidic acid receptor axis in cardiovascular diseases, Sylvain G. Bourgoin, Chenqi Zhao, Stephan Hasse, Yang Zhao, Biochemical Pharmacology, 2019, 10.1016/j.bcp.2019.03.035
  • Crystal-induced neutrophil activation. IX. Syk-dependent activation of class Ia phosphatidylinositol 3-kinase, Naccache, P.H., Bourgoin, S.G., Gilbert, C., Thibault, N., Rollet-Labelle, E., Popa-Nita, O., Journal of Leukocyte Biology, 2007, 10.1189/jlb.0307174
  • Interaction of low molecular weight group IIA phospholipase A2 with apoptotic human T cells: Role of heparan sulfate proteoglycans, Surette, M.E., Poubelle, P.E., Bernatchez, C., Bourgoin, S.G., Boilard, E., FASEB Journal, 2003, 10.1096/fj.02-0938com
  • Crystal‐induced neutrophil activation. II. evidence for the activation of a phosphatidylcholine‐specific phospholipase D, Poubelle, P.E., Lussier, A., De Medicis, R., Roberge, C.J., Plante, E., Bourgoin, S., Naccache, P.H., Arthritis & Rheumatism, 1993, 10.1002/art.1780360119
  • Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation, Bourgoin, S.G., El azreq, M.-A., Molecular Immunology, 2011, 10.1016/j.molimm.2011.03.018
  • Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: Interleukin-8, but not NAP-2 or GROα, stimulates phospholipase D activity, Naccache, P.H., McColl, S.R., Jean, N., Bourgoin, S., L'Heureux, G.P., Blood, 1995
  • ACAP1 promotes endocytic recycling by recognizing recycling sorting signals, Hsu, V.W., Peters, P.J., Bourgoin, S., Premont, R.T., Porcionatto, M., Bos, E., Li, J., Dai, J., Developmental Cell, 2004, 10.1016/j.devcel.2004.10.002
  • Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. I. Tyrosine phosphorylation-dependent stimulation of phosphatidylinositol 3-kinase and inhibition by phorbol esters, Naccache, P.H., Bourgoin, S.G., Al-Shami, A., Blood, 1997
  • Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate, Brindley, D.N., Morris, A.J., Sciorra, V.A., Bourgoin, S.G., Stromberg, L.M., Singh, I.N., Biochemistry, 2001, 10.1021/bi010787l
  • Compartmentalization of the Mitogen-Activated Protein Kinase (MAPK) in hepatic endosomes: Association with the internalized Epidermal Growth Factor (EGF) receptor, Fortier, S., Bourgoin, S., Gaulin, J.-F., Faure, R., Molecular Cell Biology Research Communications, 1999, 10.1006/mcbr.1999.0120
  • Inhibition of tyrosine phosphorylation by Wortmannin in human neutrophils. Dissociation from its inhibitory effects on phospholipase D, Bourgoin, S., Poubelle, P.E., Roberge, C.J., Gaudry, M., Gilbert, C., Caon, A.C., Naccache, P.H., Laboratory Investigation, 1993
  • Ras/mitogen-activated protein kinase mediates norepinephrine-induced phospholipase D activation in rabbit aortic smooth muscle cells by a phosphorylation-dependent mechanism, Malik, K.U., Bourgoin, S., Adl, M.Z., Khandekar, Z., Ahmed, A., Karzoun, N., Benter, I.F., Parmentier, J.-H., Muthalif, M.M., Journal of Pharmacology and Experimental Therapeutics, 2000
  • Regulation of lysophosphatidic acid receptor expression and function in human synoviocytes: Implications for rheumatoid arthritis?, Bourgoin, S.G., Poubelle, P.E., Clair, T., Di Battista, J., Turgeon, M., Prestwich, G.D., Fernandes, M.J., Zhao, C., Molecular Pharmacology, 2008, 10.1124/mol.107.038216
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) and opsonization synergistically enhance leukotriene B4(LTB4) synthesis induced by phagocytosis in human neutrophils, Borgeat, P., Naccache, P.H., Bourgoin, S., Poubelle, P.E., Agents and Actions, 1989, 10.1007/BF01972830

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Marouane Bouabane - Maîtrise avec mémoire - En cours
  • Jules Gignac - Maîtrise avec mémoire - En cours
  • Kenza Azoudj - Maîtrise avec mémoire - En cours
  • Weili Hui - Doctorat - 2017/01
  • Jadson Moreira Pereira - Doctorat - 2019/05
  • Jouda Gamara - Doctorat - 2020/05
  • Lisa Auclert - Maîtrise avec mémoire - 2020/09
  • Stephan Hasse - Doctorat - 2021/09
  • Yang Zhao - Doctorat - 2022/05

Encadrement d'étudiant(e)s pour les programmes suivants :

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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