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Sylvie Breton

Professeure titulaire

sylvie.breton.2@ulaval.ca
Centre de recherche en reproduction, développement et santé intergénérationnelle
Centre de recherche en arthrite (ARThrite)
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Projets de recherche

  • Réseau Québécois en Reproduction - Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2024-04-01 au 2030-03-31
  • Intercellular communication networks and luminal acidification in the post-testicular male reproductive tract - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-10-01 au 2027-09-30
  • Elucidating the role of the pro-inflammatory P2Y14 receptor in acute kidney injury - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-04-01 au 2027-03-31
  • Chaire de recherche du Canada en in Epithelial Dynamics of Kidney and Reproductive Organs - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2019-10-08 au 2026-10-07
  • Investigate novel markers of kidney injury in children requiring a cardiac surgery - Harvard University, Harvard University, co-chercheur - 2023-12-20 au 2024-12-19
  • Understanding the variations in clinical presentations of endometriosis: a pan-Canadian cohort study - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-03-01 au 2024-02-29
  • Réseau Québécois en Reproduction (RQR) - Fonds de recherche du Québec - Nature et technologies, Université de Sherbrooke, Université Laval - Fonds internes, Université de Montréal, Université du Québec à Trois-Rivières, Institut national de recherche scientifique (INRS) - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2017-04-01 au 2023-03-31
  • Rôle du récepteur P2Y14 dans la physiopathologie de la pré-éclampsie - CHU de Québec – Université Laval – CHUL - Subvention de fonctionnement de centre, chercheur principal - 2022-02-01 au 2023-01-31
  • Bourse de soutien aux nouveaux détenteurs de Chaire de recherche du Canada - Université Laval - Fonds internes, chercheur principal - 2019-10-01 au 2022-09-30
  • Intercellular networks and luminal acidification in the male reproductive tract - National Institute of Health (USA) - Subvention de recherche, chercheur principal - 2020-05-01 au 2022-04-30
  • Banque de données et d'échantillons biologiques humains sur l'endométriose - Université Laval - Fonds internes - BDR - Contributions, co-chercheur - 2020-12-01 au 2021-12-31

Publications

  • Loss of basolateral invaginations in proximal tubules of cadmium-intoxicated rats is independent of microtubules and clathrin, Brown, D., Breton, S., Antolovic, R., Herak-Kramberger, C. M., Sabolic, I., Toxicology Y3 - 2005, 2006, 10.1016/j.tox.2005.10.009
  • Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells, Brown, D., Breton, S., Bartlett, B. E., McLaughlin, M. M., McKee, M., Pastor-Soler, N. M., Russo, L. M., Lu, H. A., Păunescu, T. G., American journal of physiology. Renal physiology Y3 - 2013, 2013, 10.1152/ajprenal.00622.2012
  • cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells, Brown, D., Breton, S., Wagner, C. A., McLaughlin, M. M., Winter, C., Russo, L. M., Ljubojevic, M., Păunescu, T. G., American journal of physiology. Renal physiology Y3 - 2010, 2010, 10.1152/ajprenal.00584.2009
  • Acidification of the male reproductive tract by a proton pumping (H+)-ATPase, Brown, D., Lui, B., Smith, P. J., Breton, S., Nature medicine Y3 -, 1996, 10.1038/nm0496-470
  • Renal vacuolar H+-ATPase, Geibel, J. P., Brown, D., Marshansky, V., Breton, S., Finberg, K. E., Wagner, C. A., Physiological reviews Y3 -, 2004, 10.1152/physrev.00045.2003
  • Role of purinergic signaling pathways in V-ATPase recruitment to apical membrane of acidifying epididymal clear cells, Breton, S., Brown, D., Shum, W. W., Da Silva, N., Belleannée, C., American journal of physiology. Cell physiology Y3 - 2010, 2010, 10.1152/ajpcell.00460.2009
  • Pattern of protein expression in the epididymis of Oligoryzomys nigripes (Cricetidae, Sigmodontinae), Breton, S., Machado-Neves, M., Monteiro-Moreira, A. C. O., Lobo, M. D. P., de Alencar Moura, A., Hill, E., Menezes, T. P., Cell and tissue research Y3 - 2017, 2018, 10.1007/s00441-017-2714-9
  • Region-specific transcriptomic and functional signatures of mononuclear phagocytes in the epididymis, Breton, S., Nair, A. V., Brown, D., Spallanzani, R. G., Battistone, M. A., Mendelsohn, A. C., Molecular human reproduction Y3 -, 2020, 10.1093/molehr/gaz059
  • Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis, Brown, D., Breton, S., McKee, M., Marshansky, V., Da Silva, N., Paunescu, T. G., American journal of physiology. Cell physiology Y3 - 2004, 2004, 10.1152/ajpcell.00464.2003
  • Postnatal development of H+ ATPase (proton-pump)-rich cells in rat epididymis, Brown, D., Sabolic, I., Tyszkowski, R., Breton, S., Histochemistry and cell biology Y3 -, 1999, 10.1007/s004180050339
  • Reply to Edemir: Physiological regulation and single-cell RNA sequencing, Knepper, M. A., Burg, M. B., Brown, D., Wall, S. M., Verlander, J. W., Breton, S., Merkulova, M., Păunescu, T. G., Battistone, M. A., Nair, A. V., Chou, C. L., Lee, J. W., Chen, L., Proceedings of the National Academy of Sciences of the United States of America Y3 - 2018, 2018, 10.1073/pnas.1720333115
  • Epithelial basal cells are distinct from dendritic cells and macrophages in the mouse epididymis, Da Silva, N., Breton, S., Hill, E., Pittet, M. J., Roy, J. W., Grigoryeva, L. S., Cortez-Retamozo, V., Smith, T. B., Shum, W. W., Biology of reproduction Y3 - 2014, 2014, 10.1095/biolreprod.113.116681
  • Angiotensin II stimulates H⁺-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts, Geibel, J. P., Brown, D., Breton, S., Giebisch, G. H., Uhlig, U., Mohebbi, N., Wagner, C. A., Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology Y3 - 2011, 2011, 10.1159/000335112
  • New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells, Lu, H. A., Breton, S., Păunescu, T. G., Bouley, R., Brown, D., American journal of physiology. Cell physiology Y3 - 2012, 2012, 10.1152/ajpcell.00085.2012
  • Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation, Brown, D., Breton, S., Marshansky, V., Azroyan, A., Păunescu, T. G., Merkulova, M., Scientific reports Y3 - 2015, 2015, 10.1038/srep14827
  • Roles and Regulatory Mechanism of Proton Pumping V-ATPase in Spermatozoa and Epididymis Physiology, Futai, M., Okamoto, H., Breton, S., Nakanishi-Matsui, M., Testis: Anatomy, Physiology and Pathology Y3 -, 2012
  • Immunoregulatory mechanisms between epithelial clear cells and mononuclear phagocytes in the epididymis, Breton, S., Mendelsohn, A. C., Ottino, K., Barrachina, F., Elizagaray, M. L., Battistone, M. A., Andrology Y3 - 2023, 2023, 10.1111/andr.13509
  • From initial segment to cauda: a regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function, Battistone, M. A., Breton, S., Quintana, F. J., Brown, D., Spallanzani, R. G., Sanmarco, L. M., Mendelsohn, A. C., American journal of physiology. Cell physiology Y3 - 2020, 2020, 10.1152/ajpcell.00392.2020
  • Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells, Deen, P. M., Brown, D., van der Sluijs, P., Bouley, R., Pastor-Soler, N., Breton, S., van Raak, M., van Balkom, B. W., The Journal of biological chemistry Y3 - 2002, 2003, 10.1074/jbc.M207339200
  • Novel Proinflammatory Function of Renal Intercalated Cells, Brown, D., Breton, S., Annals of nutrition & metabolism Y3 - 2018, 2018, 10.1159/000488303
  • The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis, Enerbäck, S., Breton, S., Blomqvist, S. R., Heglind, M., Westergren, R., Vidarsson, H., PloS one Y3 - 2009, 2009, 10.1371/journal.pone.0004471
  • Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis, Breton, S., Futai, M., Brown, D., Marshansky, V., McKee, M., Silva, N. D., Sun-Wada, G. H., Pietrement, C., Biology of reproduction Y3 - 2005, 2006, 10.1095/biolreprod.105.043752
  • cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit, Visconti, P. E., Breton, S., Cuasnicu, P., Pilder, S. H., Sanjay, A., Pawlak, J. B., Battistone, M. A., Wertheimer, E. V., Ruan, Y. C., Krapf, D., Developmental biology Y3 - 2012, 2012, 10.1016/j.ydbio.2012.06.017
  • Potassium depletion increases proton pump (H(+)-ATPase) activity in intercalated cells of cortical collecting duct, Brown, D., Breton, S., Silver, R. B., American journal of physiology. Renal physiology Y3 -, 2000, 10.1152/ajprenal.2000.279.1.F195
  • The expression patterns of aquaporin 9, vacuolar H+-ATPase, and cytokeratin 5 in the epididymis of the common vampire bat, Machado-Neves, M., Breton, S., Freitas, M. B., Puga, L. C., Fialho, M. C., Hill, E., Kim, B., Castro, M. M., Histochemistry and cell biology Y3 - 2016, 2017, 10.1007/s00418-016-1477-9
  • Postnatal expression of aquaporins in epithelial cells of the rat epididymis, Breton, S., Brown, D., Van Hoek, A. N., Piétrement, C., Beaulieu, V., Silberstein, C., Da Silva, N., Biology of reproduction Y3 - 2005, 2006, 10.1095/biolreprod.105.044735
  • Aquaporin 9 expression along the male reproductive tract, Brown, D., Breton, S., Van Hoek, A., McKee, M., Tyszkowski, R., Sabolic, I., Bagnis, C., Pastor-Soler, N., Biology of reproduction Y3 -, 2001, 10.1095/biolreprod65.2.384
  • Role of acid/base transporters in the male reproductive tract and potential consequences of their malfunction, Breton, S., Piétrement, C., Pastor-Soler, N., Physiology Y3 -, 2005, 10.1152/physiol.00036.2005
  • Distribution pattern of ZO-1 and claudins in the epididymis of vampire bats, Machado-Neves, M., Breton, S., Serrão, J. E., Neves, C. A., Hill, E., Games, P. D., Kim, B., Castro, M. M., Tissue barriers Y3 - 2020, 2020, 10.1080/21688370.2020.1779526
  • A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse, Geibel, J. P., Giebisch, G. H., Brown, D., Breton, S., Valles, P., Lükewille, U., Wagner, C. A., Pflugers Archiv : European journal of physiology Y3 - 2003, 2003, 10.1007/s00424-003-1082-3
  • Urinary UDP-Glucose as a Novel Actionable Biomarker of Dehydration-Induced Acute Kidney Injury, Sylvie Breton, Dennis Brown, Alexandra C. Mendelsohn, Maria Agustina Battistone, Annals of Nutrition and Metabolism, 2021, 10.1159/000520566
  • Renal intercalated cells sense and mediate inflammation via the P2Y14 receptor, Breton, S., Brown, D., Pittet, M. J., Jacobson, K. A., Kiselev, E., Ruan, Y. C., Liberman, R., Bouley, R., Cortez-Retamozo, V., Azroyan, A., PloS one Y3 - 2015, 2015, 10.1371/journal.pone.0121419
  • Sensing, signaling and sorting events in kidney epithelial cell physiology, Marshansky, V., Ausiello, D. A., Breton, S., Brown, D., Traffic Y3 - 2009, 2009, 10.1111/j.1600-0854.2008.00867.x
  • The V-ATPase B1-subunit promoter drives expression of Cre recombinase in intercalated cells of the kidney, Nelson, R. D., Breton, S., Brown, D., Baumgartner, B. K., Riemondy, K. A., Lucero, O. M., Miller, R. L., Kidney international Y3 - 2008, 2009, 10.1038/ki.2008.569
  • Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge, Nahrendorf, M., Swirski, F. K., Weissleder, R., King, K. R., Pittet, M. J., Libby, P., Whalen, M., Brown, D., Breton, S., Williams, D. L., Garris, C. S., Iwamoto, Y., Courties, G., Vandoorne, K., Frodermann, V., Rohde, D., Wojtkiewicz, G., Sun, Y., Anzai, A., Herisson, F., Calcagno, D. M., Dutta, P., Nair, A. V., Hulsmans, M., Schloss, M. J., Naxerova, K., Hoyer, F. F., Immunity Y3 - 2019, 2019, 10.1016/j.immuni.2019.10.010
  • Relative contribution of clear cells and principal cells to luminal pH in the mouse epididymis†, Breton, S., Kim, B., Battistone, M. A., Park, Y. J., Biology of reproduction Y3 -, 2017, 10.1093/biolre/iox011
  • Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice, Brown, D., Barker, J. E., Sly, W. S., Gluck, S. L., Alper, S. L., Breton, S., The American journal of physiology Y3 -, 1995, 10.1152/ajprenal.1995.269.6.F761
  • Increased luminal pH in the epididymis of infertile c-ros knockout mice and the expression of sodium-hydrogen exchangers and vacuolar proton pump H+-ATPase, Cooper, T. G., Lang, F., Xu, Y., Setiawan, I., Breton, S., Yeung, C. H., Molecular reproduction and development Y3 -, 2004, 10.1002/mrd.20067
  • Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system, Cotman, S. L., de Angelis, M. H., Fuchs, H., Gailus-Durner, V., Ruether, K., Breton, S., Brown, D. E., Boustany, R. M., Wheeler, V. C., Gale, E., Dragileva, E., Guide, J., Krause, D. S., Hill, E., Harati, H., Lopez, E., Zimmer, A., Wurst, W., Wolf, E., Klopstock, T., Klingenspor, M., Graw, J., Busch, D. H., Bekeredjian, R., Racz, I., Favor, J., Sun, M., Puk, O., Adler, T., Schrewe, A., Rozman, J., Rathkolb, B., Neff, F., Calzada-Wack, J., Da Silva-Buttkus, P., Skosyrski, S., Becker, L., Hölter, S. M., Garrett, L., Biswas, S., Haliw, L., Staropoli, J. F., PloS one Y3 - 2012, 2012, 10.1371/journal.pone.0038310
  • Role of testicular luminal factors on Basal cell elongation and proliferation in the mouse epididymis, Breton, S., Da Silva, N., Shum, W. W., Roy, J., Kim, B., Biology of reproduction Y3 - 2014, 2015, 10.1095/biolreprod.114.123943
  • Cadmium inhibits vacuolar H(+)ATPase-mediated acidification in the rat epididymis, Breton, S., Brown, D., Smith, P. J., Blanusa, M., Sabolić, I., Herak-Kramberger, C. M., Biology of reproduction Y3 -, 2000, 10.1095/biolreprod63.2.599
  • Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq, Knepper, M. A., Burg, M. B., Brown, D., Wall, S. M., Verlander, J. W., Breton, S., Merkulova, M., Păunescu, T. G., Battistone, M. A., Nair, A. V., Chou, C. L., Lee, J. W., Chen, L., Proceedings of the National Academy of Sciences of the United States of America Y3 - 2017, 2017, 10.1073/pnas.1710964114
  • Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking, Marshansky, V., Breton, S., Paunescu, T. G., Brown, D., The Journal of experimental biology Y3 -, 2009, 10.1242/jeb.028803
  • Role of V-ATPase-rich cells in acidification of the male reproductive tract, Breton, S., Smith, P. J., Brown, D., The Journal of experimental biology Y3 -, 1997, 10.1242/jeb.200.2.257
  • Transepithelial projections from basal cells are luminal sensors in pseudostratified epithelia, Breton, S., Brown, D., Smith, P. J., McKee, M., Da Silva, N., Shum, W. W., Cell Y3 -, 2008, 10.1016/j.cell.2008.10.020
  • CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway, Breton, S., Chan, H. C., Brown, D., Hill, E., Diao, R. Y., Kim, B., Da Silva, N., Wang, Y., Ruan, Y. C., Journal of cell science Y3 - 2014, 2014, 10.1242/jcs.148098
  • Mitochondria-rich, proton-secreting epithelial cells, Breton, S., Brown, D., The Journal of experimental biology Y3 -, 1996, 10.1242/jeb.199.11.2345
  • CX3CR1 deficiency leads to impairment of immune surveillance in the epididymis, M. A. Battistone, S. Breton, D. Brown, R. J. Soberman, L. J. Tu, K. Ottino, F. Barrachina, Cellular and Molecular Life Sciences, 2023, 10.1007/s00018-022-04664-w
  • Regulation of vacuolar proton pumping ATPase-dependent luminal acidification in the epididymis, Breton, S., Shum, W. W., Da Silva, N., Asian journal of andrology Y3 -, 2007, 10.1111/j.1745-7262.2007.00299.x
  • Commentary: Novel preoperative predictors of acute kidney injury following cardiac surgery: Is it a game changer?, Mohammadi, S., Kalavrouziotis, D., Breton, S., The Journal of thoracic and cardiovascular surgery Y3 - 2021, 2021, 10.1016/j.jtcvs.2021.04.055
  • V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice, Nelson, R. D., Breton, S., Brown, D., Paunescu, T. G., Beaulieu, V., Smith, M., Zhang, P., Miller, R. L., American journal of physiology. Cell physiology Y3 - 2005, 2005, 10.1152/ajpcell.00084.2004
  • In vivo imaging of tracheal epithelial cells in mice during airway regeneration, Yun, S. H., Rajagopal, J., Breton, S., Pardo-Saganta, A., Lam, A., Choi, J., Jung, K., Zhao, R., Wain, J., Vinarsky, V., Kim, J. K., American journal of respiratory cell and molecular biology Y3 - 2012, 2012, 10.1165/rcmb.2012-0164OC
  • Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling, Breton, S., Brown, D., Smith, P. J., Brown, C. R., Pastor-Soler, N., Da Silva, N., Beaulieu, V., The Journal of biological chemistry Y3 - 2004, 2005, 10.1074/jbc.M412750200
  • Regulation of luminal acidification by the V-ATPase, Brown, D., Breton, S., Physiology Y3 -, 2013, 10.1152/physiol.00007.2013
  • Unravelling purinergic regulation in the epididymis: activation of V-ATPase-dependent acidification by luminal ATP and adenosine, Breton, S., Brown, D., Gombar, F., Park, Y. J., Peralta, M. A., Merkulova, M., Battistone, M. A., The Journal of physiology Y3 - 2019, 2019, 10.1113/JP277565
  • Modulation of the onset of postnatal development of H(+)-ATPase-rich cells by steroid hormones in rat epididymis, Breton, S., Sharpe, R. M., Pastor-Soler, N., Fisher, J. S., Biology of reproduction Y3 -, 2002, 10.1095/biolreprod67.4.1106
  • Aquaporin 2 is a vasopressin-independent, constitutive apical membrane protein in rat vas deferens, Brown, D., Kohan, D. E., Nelson, R. D., Bouley, R., Gustafson, C. E., Breton, S., Stevens, A. L., American journal of physiology. Cell physiology Y3 -, 2000, 10.1152/ajpcell.2000.278.4.C791
  • Establishment of cell-cell cross talk in the epididymis: control of luminal acidification, Breton, S., Da Silva, N., Ruan, Y. C., Shum, W. W., Journal of andrology Y3 - 2011, 2011, 10.2164/jandrol.111.012971
  • Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y14 Receptor Antagonists, Jacobson, K. A., Cook, D. N., Salvemini, D., Breton, S., Liang, B. T., Whitehead, G. S., Giancotti, L. A., Chen, Z., Cronin, C., Randle, J. C. R., Gao, Z. G., Jung, Y. H., Lewicki, S. A., Pramanik, A., Wen, Z., Journal of medicinal chemistry Y3 - 2023, 2023, 10.1021/acs.jmedchem.3c00664
  • Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ, Marshansky, V., Ausiello, D. A., Bourgoin, S., Brown, D., Breton, S., El-Annan, J., American journal of physiology. Cell physiology Y3 - 2003, 2004, 10.1152/ajpcell.00250.2003
  • Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice, Breton, S., Brown, D., Lazarowski, E. R., Bonventre, J. V., Wall, S. M., Kalim, S., Sesma, J., Liberman, R. N., Allegretti, A. S., Spallanzani, R. G., Mendelsohn, A. C., Battistone, M. A., The Journal of clinical investigation Y3 -, 2020, 10.1172/JCI134791
  • Regulation of luminal acidification in the male reproductive tract via cell-cell crosstalk, Breton, S., Brown, D., Da Silva, N., Shum, W. W., The Journal of experimental biology Y3 -, 2009, 10.1242/jeb.027284
  • Segmental expression of the bradykinin type 2 receptor in rat efferent ducts and epididymis and its role in the regulation of aquaporin 9, Breton, S., Brown, D., Laprade, R., Marsolais, M., Shum, W. W., Da Silva, N., Belleannée, C., Biology of reproduction Y3 - 2008, 2009, 10.1095/biolreprod.108.070797
  • Immunolocalization of AE2 anion exchanger in rat and mouse epididymis, Breton, S., Alper, S. L., Lux, S. E., Peters, L. L., Stuart-Tilley, A. K., Jensen, L. J., Biology of reproduction Y3 -, 1999, 10.1095/biolreprod61.4.973
  • The B1-subunit of the H(+) ATPase is required for maximal urinary acidification, Lifton, R. P., Geibel, J. P., Giebisch, G., Brown, D., Breton, S., Paunescu, T. G., Bailey, M. A., Wagner, C. A., Finberg, K. E., Proceedings of the National Academy of Sciences of the United States of America Y3 - 2005, 2005, 10.1073/pnas.0506769102
  • Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra), Brown, D., Breton, S., McLaughlin, M., Cohen, O., Pastor-Soler, N., Bouley, R., American journal of physiology. Renal physiology Y3 - 2005, 2005, 10.1152/ajprenal.00337.2004
  • Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells, Brown, D., Breton, S., Lu, H. A., McKee, M., Russo, L. M., Da Silva, N., Paunescu, T. G., American journal of physiology. Renal physiology Y3 - 2007, 2008, 10.1152/ajprenal.00406.2007
  • Revisiting structure/functions of the human epididymis, Soulet, D., Breton, S., Lamontagne-Proulx, J., Légaré, C., Sullivan, R., Andrology Y3 - 2019, 2019, 10.1111/andr.12633
  • Sperm acquire epididymis-derived proteins through epididymosomes, Oliva, R., Breton, S., Jodar, M., Mallofré, C., Castillo, J., Battistone, M. A., Barrachina, F., Human reproduction (Oxford, England) Y3 -, 2022, 10.1093/humrep/deac015
  • Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging, Breton, S., Brown, D., Weissleder, R., Vinegoni, C., Krapf, D., Visconti, P., Hill, E., Kim, B., Roy, J., Nature communications Y3 - 2016, 2016, 10.1038/ncomms10666
  • Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens, Breton, S., Brown, D., Van Hoek, A., Sabolic, I., Herak-Kramberger, C., Isnard-Bagnis, C., Pastor-Soler, N., Biology of reproduction Y3 -, 2002, 10.1095/biolreprod66.6.1716
  • Renal principal cell-specific expression of green fluorescent protein in transgenic mice, Nelson, R. D., Brown, D., Breton, S., Chipman, G., Kohan, D. E., Stricklett, P. K., Zhu, X., Zharkikh, L., American journal of physiology. Renal physiology Y3 -, 2002, 10.1152/ajprenal.0224.2001
  • Caput Ligation Renders Immature Mouse Sperm Motile and Capable to Undergo cAMP-Dependent Phosphorylation, Gervasi, M. G., Visconti, P. E., Breton, S., Salicioni, A. M., Battistone, M. A., Tourzani, D. A., International journal of molecular sciences Y3 - 2021, 2021, 10.3390/ijms221910241
  • Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling, Breton, S., Levin, L. R., Buck, J., Brown, D., Chen, Y., Da Silva, N., Litvin, T. N., Beaulieu, V., Pastor-Soler, N., The Journal of biological chemistry Y3 - 2003, 2003, 10.1074/jbc.M309543200
  • Altered V-ATPase expression in renal intercalated cells isolated from B1 subunit-deficient mice by fluorescence-activated cell sorting, Paunescu, T. G., Brown, D., Breton, S., Hill, E., Azroyan, A., Wagner, C. A., Finberg, K. E., Rothermel, J. T., Vedovelli, L., American journal of physiology. Renal physiology Y3 - 2012, 2013, 10.1152/ajprenal.00394.2012
  • ATP secretion in the male reproductive tract: essential role of CFTR, Breton, S., Da Silva, N., Belleannée, C., Shum, W. W., Ruan, Y. C., The Journal of physiology Y3 - 2012, 2012, 10.1113/jphysiol.2012.230581
  • Purinergic signaling in the male reproductive tract, Breton, S., Battistone, M. A., Légaré, C., Brochu, K., Belardin, L. B., Frontiers in endocrinology Y3 - 2022, 2022, 10.3389/fendo.2022.1049511
  • Impaired male fertility and abnormal epididymal epithelium differentiation in mice lacking CRISP1 and CRISP4, Cuasnicu, P. S., Breton, S., Lustig, L., Haruhiko, M., Ikawa, M., Guazzone, V. A., Battistone, M. A., Brukman, N. G., Weigel Muñoz, M., Carvajal, G., Scientific reports Y3 - 2018, 2018, 10.1038/s41598-018-35719-3
  • High-resolution helium ion microscopy of epididymal epithelial cells and their interaction with spermatozoa, Breton, S., Brown, D., Goetze, B., Lechner, L., Huynh, C., Shum, W. W., Păunescu, T. G., Molecular human reproduction Y3 - 2014, 2014, 10.1093/molehr/gau052
  • Na+/H+-exchange activity and immunolocalization of NHE3 in rat epididymis, Breton, S., Laprade, R., Biemesderfer, D., Marsolais, M., Bagnis, C., American journal of physiology. Renal physiology Y3 -, 2001, 10.1152/ajprenal.2001.280.3.F426
  • Segmental and cellular expression of aquaporins in the male excurrent duct, Breton, S., Brown, D., Piétrement, C., Da Silva, N., Biochimica et biophysica acta Y3 - 2006, 2006, 10.1016/j.bbamem.2006.06.026
  • The cellular physiology of carbonic anhydrases, Breton, S., JOP : Journal of the pancreas Y3 -, 2001
  • Na/K-ATPase in intercalated cells along the rat nephron revealed by antigen retrieval, Brown, D., Breton, S., Herak-Kramberger, C. M., Sabolić, I., Journal of the American Society of Nephrology : JASN Y3 -, 1999, 10.1681/ASN.V105913
  • ROS1 signaling regulates epithelial differentiation in the epididymis, Charest, A., Breton, S., Haigis, K. M., Bronson, R. T., Punko, D., Woolfenden, S., Lane, K., Wood, L. B., Smith, T. B., Roy, J., Jun, H. J., Endocrinology Y3 - 2014, 2014, 10.1210/en.2014-1341
  • Nitric oxide and atrial natriuretic factor stimulate cGMP-dependent membrane insertion of aquaporin 2 in renal epithelial cells, Brown, D., Ausiello, D. A., Lin, H. Y., Nsumu, N. N., McLaughlin, M., Sun, T., Breton, S., Bouley, R., The Journal of clinical investigation Y3 -, 2000, 10.1172/JCI9594
  • Basolateral distribution of caveolin-1 in the kidney. Absence from H+-atpase-coated endocytic vesicles in intercalated cells, Brown, D., McLaughlin, M., Tyszkowski, R., Lisanti, M. P., Breton, S., The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society Y3 -, 1998, 10.1177/002215549804600209
  • Aquaporin 9 expression in the developing rat epididymis is modulated by steroid hormones, Breton, S., Brown, D., Van Hoek, A., Hill, E., Sharpe, R., Fisher, J. S., Pastor-Soler, N. M., Reproduction (Cambridge, England) Y3 - 2009, 2010, 10.1530/REP-09-0284
  • Unexpected Participation of Intercalated Cells in Renal Inflammation and Acute Kidney Injury, Battistone, M. A., Breton, S., Nephron Y3 - 2021, 2022, 10.1159/000519265
  • Extracellular Adenosine Stimulates Vacuolar ATPase-Dependent Proton Secretion in Medullary Intercalated Cells, Breton, S., Brown, D., Capen, D. E., Peralta, M. A., Liberman, R. N., Barton, C. R., Nair, A. V., Battistone, M. A., Journal of the American Society of Nephrology : JASN Y3 - 2017, 2018, 10.1681/ASN.2017060643
  • A liquid chromatography-mass spectrometry assay for the quantification of nucleotide sugars in human plasma and urine specimens and its clinical application, Guillemette, C., Breton, S., Lévesque, É, Mohammadi, S., Fortin, P., Bujold, E., Rouleau, M., Nguyen Van Long, F., Caron, P., Journal of chromatography. A Y3 - 2022, 2022, 10.1016/j.chroma.2022.463296
  • Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells, Breton, S., Brown, D., McKee, M., Belleannée, C., Da Silva, N., Shum, W. W., American journal of physiology. Cell physiology Y3 - 2011, 2011, 10.1152/ajpcell.00198.2010
  • The MAPK/ERK signaling pathway regulates the expression and localization of Cx43 in mouse proximal epididymis†, Breton, S., Kim, B., Biology of reproduction Y3 -, 2022, 10.1093/biolre/ioac034
  • Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in the caput epididymis, Breton, S., Brown, D., Păunescu, T. G., Vedovelli, L., Ruan, Y. C., Hill, E., Roy, J. W., American journal of physiology. Cell physiology Y3 - 2013, 2013, 10.1152/ajpcell.00410.2012
  • The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells, Brown, D., Ramesh, V., Nsumu, N. N., Marshansky, V., Wiederhold, T., Breton, S., The Journal of biological chemistry Y3 -, 2000, 10.1074/jbc.M909857199
  • Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition, Brown, D., Breton, S., Marshansky, V., Bagnis, C., American journal of physiology. Renal physiology Y3 -, 2001, 10.1152/ajprenal.2001.280.3.F437
  • Distribution of the vacuolar H+ atpase along the rat and human male reproductive tract, Sabolic, I., Kraus, O., Brown, D., Breton, S., Herak-Kramberger, C. M., Biology of reproduction Y3 -, 2001, 10.1095/biolreprod64.6.1699
  • Dedifferentiation of committed epithelial cells into stem cells in vivo, Rajagopal, J., Medoff, B. D., Sahay, A., Breton, S., Cho, J. L., Vinarsky, V., Law, B. M., Prabhu, M., Zhao, R., Pardo-Saganta, A., Mou, H., Tata, P. R., Nature Y3 - 2013, 2013, 10.1038/nature12777
  • Expression of the pro-inflammatory P2Y14 receptor in the non-vasectomized and vasectomized human epididymis, Breton, S., Belleannée, C., Sullivan, R., Légaré, C., Belardin, L. B., Andrology Y3 - 2022, 2022, 10.1111/andr.13284
  • Novel role of proton-secreting epithelial cells in sperm maturation and mucosal immunity, Breton, S., Brown, D., Nair, A. V., Capen, D., Mendelsohn, A. C., Spallanzani, R. G., Battistone, M. A., Journal of cell science Y3 - 2019, 2019, 10.1242/jcs.233239
  • Membrane macro-and microdomains in electrolyte transporting epithelia: structure-function correlations, Breton, S., Sabolic, I., Brown, D., The kidney : physiology and pathophysiology Y3 -, 2000
  • Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice, Brown, D., Breton, S., Wagner, C. A., McKee, M., Van Hoek, A. N., Mohebbi, N., Kovacikova, J., Da Silva, N., Russo, L. M., Paunescu, T. G., American journal of physiology. Renal physiology Y3 - 2007, 2007, 10.1152/ajprenal.00160.2007
  • Targeted deletion of the Ncoa7 gene results in incomplete distal renal tubular acidosis in mice, Brown, D., Breton, S., Oliver, P. L., Capen, D. E., Wang, C. Y., Nair, A. V., Păunescu, T. G., Merkulova, M., American journal of physiology. Renal physiology Y3 - 2018, 2018, 10.1152/ajprenal.00407.2017
  • Proton secretion in the male reproductive tract: involvement of Cl--independent HCO-3 transport, Brown, D., Smith, P. J., Hammar, K., Breton, S., The American journal of physiology Y3 -, 1998, 10.1152/ajpcell.1998.275.4.C1134
  • Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit, Breton, S., Brown, D., Smith, P. J., McKee, M., Păunescu, T. G., El-Annan, J., Shum, W. W., Da Silva, N., American journal of physiology. Cell physiology Y3 - 2007, 2007, 10.1152/ajpcell.00596.2006
  • Antigen retrieval reveals widespread basolateral expression of syntaxin 3 in renal epithelia, Brown, D., Knepper, M. A., Inoue, T., Breton, S., American journal of physiology. Renal physiology Y3 -, 2002, 10.1152/ajprenal.00128.2001
  • Localization of sodium bicarbonate cotransporter (NBC) protein and messenger ribonucleic acid in rat epididymis, Breton, S., Brown, D., Hediger, M. A., Boron, W. F., Nsumu, N. N., Berger, U. V., Schmitt, B. M., Jensen, L. J., Biology of reproduction Y3 -, 1999, 10.1095/biolreprod60.3.573
  • Pendrin regulation in mouse kidney primarily is chloride-dependent, Eladari, D., Chambrey, R., Aronson, P. S., Loffing, J., Meneton, P., Breton, S., Deschênes, G., Bloch-Faure, M., Fysekidis, M., Loffing-Cueni, D., Picard, N., Vallet, M., Journal of the American Society of Nephrology : JASN Y3 - 2006, 2006, 10.1681/ASN.2005101054
  • New insights into the regulation of V-ATPase-dependent proton secretion, Breton, S., Brown, D., American journal of physiology. Renal physiology Y3 - 2006, 2007, 10.1152/ajprenal.00340.2006
  • Epithelial dynamics in the epididymis: role in the maturation, protection, and storage of spermatozoa, Battistone, M. A., Nair, A. V., Breton, S., Andrology Y3 - 2019, 2019, 10.1111/andr.12632
  • The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer, Forgac, M., Breton, S., Brown, D., Naber, S., Sgroi, D., Wada, Y., Sun-Wada, G., Liberman, R., Cotter, K., Oncotarget Y3 -, 2016, 10.18632/oncotarget.10063
  • Is caveolin involved in normal proximal tubule function? Presence in model PT systems but absence in situ, Brown, D., Breton, S., Marshansky, V., Zhuang, Z., American journal of physiology. Renal physiology Y3 - 2010, 2011, 10.1152/ajprenal.00513.2010
  • Tetanus toxin-mediated cleavage of cellubrevin inhibits proton secretion in the male reproductive tract, Brown, D., Smith, P. J., Sabolic, I., Galli, T., Nsumu, N. N., Breton, S., American journal of physiology. Renal physiology Y3 -, 2000, 10.1152/ajprenal.2000.278.5.F717
  • Plasticity of basal cells during postnatal development in the rat epididymis, Breton, S., Brown, D., Hill, E., Shum, W. W., Reproduction (Cambridge, England) Y3 - 2013, 2013, 10.1530/REP-12-0510
  • Androgens are essential for epithelial cell recovery after efferent duct ligation in the initial segment of the mouse epididymis†, Breton, S., Kim, B., Biology of reproduction Y3 -, 2020, 10.1093/biolre/ioz152
  • The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis, Breton, S., Kim, B., Biology of reproduction Y3 - 2015, 2016, 10.1095/biolreprod.115.134965
  • Regulation of epithelial function, differentiation, and remodeling in the epididymis, Kim, B., Park, Y. J., Ruan, Y. C., Breton, S., Asian journal of andrology Y3 -, 2016, 10.4103/1008-682X.165946
  • A dense network of dendritic cells populates the murine epididymis, Breton, S., Pittet, M. J., Swirski, F. K., Brown, D., Hill, E., Wildgruber, M., Reinecker, H. C., Cortez-Retamozo, V., Da Silva, N., Reproduction (Cambridge, England) Y3 - 2011, 2011, 10.1530/REP-10-0493
  • Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9, Breton, S., Ramesh, V., Laprade, R., Ameen, N., Pastor-Soler, N., Brown, D., Van Hoek, A., Marsolais, M., James, M., Silberstein, C., Da Silva, N., Pietrement, C., The Journal of biological chemistry Y3 - 2007, 2008, 10.1074/jbc.M704678200
  • H(+)V-ATPase-dependent luminal acidification in the kidney collecting duct and the epididymis/vas deferens: vesicle recycling and transcytotic pathways, Breton, S., Brown, D., The Journal of experimental biology Y3 -, 2000, 10.1242/jeb.203.1.137
  • Proteomic analysis of V-ATPase-rich cells harvested from the kidney and epididymis by fluorescence-activated cell sorting, Breton, S., Brown, D., Knepper, M. A., Nelson, R., Miller, L. R., Belleannée, C., Pisitkun, T., Da Silva, N., American journal of physiology. Cell physiology Y3 - 2010, 2010, 10.1152/ajpcell.00552.2009
  • Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells, Breton, S., Brown, D., Gong, F., Smolak, C., Hallows, K. R., Pastor-Soler, N. M., American journal of physiology. Cell physiology Y3 - 2007, 2008, 10.1152/ajpcell.00537.2007
  • Sorting proteins to their target membranes, Breton, S., Brown, D., Kidney international Y3 -, 2000, 10.1046/j.1523-1755.2000.00920.x
  • Detection of ClC-3 and ClC-5 in epididymal epithelium: immunofluorescence and RT-PCR after LCM, Breton, S., Brown, D., Yu, A. S., Beaulieu, V., Da Silva, N., Isnard-Bagnis, C., American journal of physiology. Cell physiology Y3 -, 2003, 10.1152/ajpcell.00374.2001

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Jean-Philippe C Lavoie - Doctorat - En cours
  • Emma Cavarocchi - Post-doctorat - En cours
  • Morgane Goux - Maîtrise avec mémoire - En cours
  • Kéliane Brochu - Maîtrise avec mémoire - 2023/05
*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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