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Thomas Moss

Professeur titulaire

Thomas Moss
thomas.moss.1@ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche sur le cancer
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Carcinogénèse
  • Différenciation cellulaire
  • Facteurs de croissance
  • Gène suppresseur
  • Oncogènes
  • Signalisation cellulaire et cancer
Cellulaire
  • Cellule
  • Chromosome
  • Gène
Subcellulaire
  • Acides nucléiques
Génomique et protéomique
  • Bio-informatique
  • Génotype et phénotype
  • Mécanismes biologiques et biochimiques

Projets de recherche

  • Pathobiology and treatment of the UBTF E210K neuroregression syndrome - National Institute of Health (USA) - Subvention de recherche, University of Memphis, co-chercheur - 2021-07-01 au 2026-06-30
  • The Ribosomal RNA Genes in Growth, Pluripotency, Senescence and Cancer - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2024-03-01 au 2025-02-28
  • Mechanism of Ribosomal RNA Gene Silencing and Its Roles in Pluripotency and Cancer - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2017-04-01 au 2022-03-31
  • Role of Misshappen (NIK/Msn) kinases and Extended-Synaptotagmins (E-Syts) in Wnt and FGF intracellular signaling pathways. - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2017-04-01 au 2022-03-31

Publications

  • Readthrough enhancement and promoter occlusion on the ribosomal genes of Xenopus laevis, , Biochemistry and Cell Biology, 1992
  • Identification of a mammalian RNA polymerase I holoenzyme containing components of the DNA repair/replication system, , Nucleic acids research, 1999
  • The splice variants of UBF differentially regulate RNA polymerase I transcription elongation in response to ERK phosphorylation, , Nucleic acids research, 2008
  • UV-laser crosslinking of proteins to DNA, , Methods, 1997
  • Loss of human ribosomal gene CpG methylation enhances cryptic RNA polymerase II transcription and disrupts ribosomal RNA processing, , Molecular cell, 2009
  • DNA methyltransferase inhibition may limit cancer cell growth by disrupting ribosome biogenesis, , Epigenetics, 2011
  • Affinity purification of mammalian RNA polymerase I Identification of an associated kinase, , Journal of Biological Chemistry, 1998
  • DNase I Footprinting, Tom Moss, Benoît Leblanc, DNA-Protein Interactions, 1911, 10.1385/1-59259-208-2:031
  • EphA4 signaling regulates blastomere adhesion in the Xenopus embryo by recruiting Pak1 to suppress Cdc42 function, , Molecular biology of the cell, 2007
  • An immediate response to ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF (vol 8, pg 1063, 2001), , MOLECULAR CELL, 2002
  • Overexpression of the transcription factor UBF1 is sufficient to increase ribosomal DNA transcription in neonatal cardiomyocytes: implications for cardiac hypertrophy, , Proceedings of the National Academy of Sciences, 1996
  • Disruption of the UBF gene induces aberrant somatic nucleolar bodies and disrupts embryo nucleolar precursor bodies, Tom Moss, Attila Németh, Victor Y. Stefanovsky, Stefan Dillinger, Michel G. Tremblay, Nourdine Hamdane, Gene, 2017, 10.1016/j.gene.2016.09.013
  • The putative promoter of a Xenopus laevis ribosomal gene is reduplicated, Max L. Birnstiel, Tom Moss, Nucleic Acids Research, 1979, 10.1093/nar/6.12.3733
  • Transcription factor UBF depletion in mouse cells results in downregulation of both downstream and upstream elements of the rRNA transcription network., Santama N, Moss T, Dany Sibai, Mattheou C, Christodoulou A, Theophanous A, The Journal of biological chemistry, 2023, 10.1016/j.jbc.2023.105203
  • The DNA supercoiling architecture induced by the transcription factor xUBF requires three of its five HMG-boxes, , Nucleic acids research, 1996
  • The chromatin landscape of the ribosomal RNA genes in mouse and human, Marianne Sabourin-Felix, Michel G. Tremblay, Jean-Clement Mars, Tom Moss, Chromosome Research, 2019, 10.1007/s10577-018-09603-9
  • Identification of a novel xPAK1 partner important for proper FGF signaling in Xenopus laevis, , Developmental Biology, 2006
  • A recurrent de novo missense mutation in UBTF causes developmental neuroregression., LeDoux MS, Reiter LT, Hope KA, Tian J, Khan MM, Xiao J, Wolfe LA, Harper F, Adams DR, Gahl WA, Goldstein A, Tifft CJ, Malicdan MCV, Hori RT, Toro C, Human molecular genetics, 2018, 10.1093/hmg/ddx435
  • The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption, DNA damage and cell inviability, Tom Moss, Frédéric Lessard, Marianne Sabourin-Felix, Dany S Sibai, Mélissa Valere, Michel G Tremblay, Jean-Clément Mars, NAR Cancer, 2020, 10.1093/narcan/zcaa032
  • HMG-boxes, ribosomopathies and neurodegenerative disease., Crane-Robinson C, LeDoux MS, Moss T, Frontiers in genetics, 2023, 10.3389/fgene.2023.1225832
  • Variants of the Xenopus laevis ribosomal transcription factor xUBF are developmentally regulated by differential splicing, , Nucleic acids research, 1992
  • Loss of Extended Synaptotagmins ESyt2 and ESyt3 does not affect mouse development or viability, but in vitro cell migration and survival under stress are affected, , Cell Cycle, 2014
  • DNA methyltransferase inhibition may limit cancer cell growth by disrupting ribosome biogenesis, Tom Moss, Epigenetics, 2011, 10.4161/epi.6.2.13625
  • A ubiquitin-conjugating enzyme, ube2d3. 2, regulates xMLK2 and pronephros formation in Xenopus, , Differentiation, 2008
  • Bidirectional cooperation between Ubtf1 and SL1 determines RNA Polymerase I promoter recognition in cell and is negatively affected in the UBTF-E210K neuroregression syndrome, Tom Moss, Mark S. Ledoux, Victor Y. Stefanovsky, Mohammad M. Khan, Roderick T. Hori, Frédéric Lessard, Jean-Clément Mars, Melissa Valère, Dany S. Sibai, Michel G. Tremblay, 2021, 10.1101/2021.06.07.447350
  • Regulation of rRNA synthesis in human and mouse cells is not determined by changes in active gene count, , Cell Cycle, 2006
  • A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes, , Genome research, 2015
  • UV Laser-Induced Protein-DNA Crosslinking, Tom Moss, Stefan I. Dimitrov, DNA-Protein Interactions, 1911, 10.1385/1-59259-208-2:395
  • Behavioral and molecular effects of Ubtf knockout and knockdown in mice., LeDoux MS, Moss T, Hargrove PW, Xiao J, Moshahid Khan M, Hori RT, Brain research, 2022, 10.1016/j.brainres.2022.148053
  • An analysis of Xenopus tyrosine kinase genes and their expression in early development, , DNA and cell biology, 1994
  • Metabolic Labeling in the Study of Mammalian Ribosomal RNA Synthesis, Tom Moss, Victor Y. Stefanovsky, The Nucleolus, 2016, 10.1007/978-1-4939-3792-9_11
  • Mlk2, Thomas Moss, Nicolas Bisson, AfCS-Nature Molecule Pages, 2009, 10.1038/mp.a001550.01
  • A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription, Tom Moss, Mark D. Robinson, Helen Lindsay, Marianne Sabourin-Felix, Michel G. Tremblay, Victor Y. Stefanovsky, Jean-Clement Mars, Chelsea Herdman, PLOS Genetics, 2017, 10.1371/journal.pgen.1006899
  • Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling, , Molecular cell, 2006
  • Physical studies on the H3/H4 histone tetramer, E. M. Bradbury, Colyn Crane-Robinson, Peter D. Cary, Tom Moss, Biochemistry, 1976, 10.1021/bi00656a003
  • A complex array of sequences enhances ribosomal transcription in Xenopus laevis, , Journal of molecular biology, 1987
  • The RNA polymerase I transcription factor xUBF contains 5 tandemly repeated HMG homology boxes, , Nucleic acids research, 1991
  • Agonistic and antagonistic roles for TNIK and MINK in non-canonical and canonical Wnt signalling, , PLoS One, 2012
  • High-resolution proton-magnetic-resonance studies of chromatin core particles, , European Journal of Biochemistry, 1978
  • PAK interacts with NCK and MLK2 to regulate the activation of jun N-terminal kinase, , FEBS letters, 2003
  • 5'-Labeling and poly (dA) tailing., , Methods in enzymology, 1979
  • A pH-Dependent Interaction between Histones H2A and H2B Involving Secondary and Tertiary Folding, , European Journal of Biochemistry, 1976
  • The enhancement of ribosomal transcription by the recycling of RNA polymerase I, , Nucleic acids research, 1987
  • The Short N-Terminal Repeats of Transcription Termination Factor 1 Contain Semi-Redundant Nucleolar Localization Signals and P19-ARF Tumor Suppressor Binding Sites., , The Yale journal of biology and medicine, 2019
  • High resolution studies of the Xenopus laevis ribosomal gene promoter in vivo and in vitro., , Journal of Biological Chemistry, 1992
  • DNA-Protein Interactions: Principles and Protocols. Methods in Molecular Biology, , 2001
  • DNA–Protein Interactions: Principles and Protocols, 2nd ed. Edited by Tom Moss, Leo Kretzner, Analytical Biochemistry, 2002, 10.1006/abio.2002.5609
  • A housekeeper with power of attorney: the rRNA genes in ribosome biogenesis, , Cellular and molecular life sciences, 2007
  • Readthrough enhancement and promoter occlusion on the ribosomal genes of Xenopus laevis, Benoît Leblanc, Keith Mitchelson, Anne-Marie Larose, Tom Moss, Biochemistry and Cell Biology, 1992, 10.1139/o92-050
  • The ribosomal spacer in Xenopus laevis is transcribed as part of the primary ribosomal RNA, , Nucleic acids research, 1986
  • A model for the topology of active ribosomal RNA genes, , EMBO reports, 2011
  • DNase I footprinting, , DNA-Protein Interactions, 2009
  • The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis, , Molecular biology of the cell, 2005
  • Sequence organization of the spacer DNA in a ribosomal gene unit of Xenopus laevis, , Cell, 1979
  • IS048 The a_1-Adrenergic Responsive Transcription Factor, UBF1, Regulates rDNA Transcription in Neonatal Cardiomyocytes, , Japanese circulation journal, 1998
  • A new paradigm for the regulation of the mammalian ribosomal RNA genes., , Biochemical Society Transactions, 2006
  • DNA-Protein Interactions, Tom Moss, 2001, 10.1385/1592592082
  • Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells., Moss T, Tremblay MG, Stefanovsky V, Mars JC, Herdman C, Hamdane N, 2015, 10.18632/oncotarget.4823
  • DNase I Footprinting, Tom Moss, Benoît Leblanc, DNA-Protein Interactions, 1911, 10.1385/0-89603-256-6:1
  • Heterogeneity in the Xenopus ribosomal transcription factor xUBF has a molecular basis distinct from that in mammals, , FEBS letters, 1991
  • The cruciform DNA mobility shift assay: a tool to study proteins that recognize bent DNA, , DNA-Protein Interactions, 2009
  • Catalytic and non-catalytic forms of the neurotrophin receptor xTrkB mRNA are expressed in a pseudo-segmental manner within the early Xenopus central nervous system., , The International journal of developmental biology, 1996
  • The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I, , Molecular cell, 2010
  • 4. Fragile X Related 1 (xFxr1) de Xenopus laevis et la myogenèse primaire., , Résumé, 1911
  • ERK modulates DNA bending and enhancesome structure by phosphorylating HMG1-boxes 1 and 2 of the RNA polymerase I transcription factor UBF, , Biochemistry, 2006
  • A transcriptional function for the repetitive ribosomal spacer in Xenopus laevis, Tom Moss, Nature, 1983, 10.1038/302223a0
  • Short-range DNA looping by the Xenopus HMG-box transcription factor, xUBF, , Science, 1994
  • Mlk1, Thomas Moss, Nicolas Bisson, AfCS-Nature Molecule Pages, 2009, 10.1038/mp.a001549.01
  • More ribosomal spacer sequences from Xenopus laevis, , Nucleic acids research, 1980
  • TTF1 control of LncRNA synthesis delineates a tumor suppressor pathway directly regulating the ribosomal RNA genes, Tom Moss, Mark Robinson, Marianne Sabourin‐Félix, Christophe Tav, Frédéric Lessard, Michel G. Tremblay, Dany S. Sibai, Journal of Cellular Physiology, 2024, 10.1002/jcp.31303
  • DNA-Protein Interactions. Principles and Protocols, second edition, edited by Tom Moss, Humana Press, 2001, 638 p., Olivier Leroy, Biochimie, 2001, 10.1016/s0300-9084(01)01337-2
  • Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo, , Developmental cell, 2010
  • The endocytic adapter E-Syt2 recruits the p21 GTPase activated kinase PAK1 to mediate actin dynamics and FGF signalling, , Biology open, 2012
  • UV Laser-Induced Protein–DNA Crosslinking, Tom Moss, Stefan I. Dimitrov, DNA-Protein Interactions, 1911, 10.1385/0-89603-256-6:227
  • A Deconvolution Protocol for ChIP-Seq Reveals Analogous Enhancer Structures on the Mouse and Human Ribosomal RNA Genes, Tom Moss, Michel G. Tremblay, Marianne Sabourin-Felix, Jean-Clement Mars, G3: Genes|Genomes|Genetics, 2018, 10.1534/g3.117.300225
  • A tissue restricted role for the Xenopus Jun N-terminal kinase kinase kinase MLK2 in cement gland and pronephric tubule differentiation, , Developmental biology, 2003
  • A transcriptional function for the repetitive ribosomal spacer in Xenopus laevis, , Nature, 1983
  • Ribosomal DNA promoter recognition is determined in vivo by cooperation between UBTF1 and SL1 and is compromised in the UBTF-E210K neuroregression syndrome, Tom Moss, Mark S. LeDoux, Victor Y. Stefanovsky, Mohammad Moshahid Khan, Roderick T. Hori, Frédéric Lessard, Jean-Clément Mars, Melissa Valère, Dany S. Sibai, Michel G. Tremblay, PLOS Genetics, 2022, 10.1371/journal.pgen.1009644
  • DNA-Protein Interactions, , Methods in Molecular Biology™, 2009, 10.1007/978-1-60327-015-1
  • Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription, , Molecular cell, 2000
  • Gènes ribosomiques et régulation de la croissance cellulaire, Emmanuel Käs, Nicolas Bissont, Tom Moss, médecine/sciences, 2002, 10.1051/medsci/20021810940
  • In Vitro DNase I Footprinting, Tom Moss, Benoît P. Leblanc, DNA-Protein Interactions, 2015, 10.1007/978-1-4939-2877-4_2
  • Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype, , Cell Cycle, 2008
  • Cellular regulation of ribosomal DNA transcription: both rat and Xenopus UBF1 stimulate rDNA transcription in 3T3 fibroblasts, , Nucleic acids research, 1999
  • Antisense and sense poly (A)- RNAs from the Xenopus laevis pyruvate dehydrogenase gene loci are regulated with message production during embryogenesis, , Gene, 1996
  • An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF, , Molecular cell, 2001
  • Coordinate replication of dispersed repetitive sequences in Physarum polycephalum, , Experimental cell research, 1989
  • UV laser-induced protein-DNA crosslinking, , DNA-Protein Interactions, 2001
  • UBF levels determine the number of active ribosomal RNA genes in mammals, , The Journal of cell biology, 2008
  • Promotion and Regulation of Ribosomal Transcription in Eukaryotes by RNA Polymerase, Victor Y. Stefanovsky, Tom Moss, Progress in Nucleic Acid Research and Molecular Biology, 1995, 10.1016/s0079-6603(08)60810-7
  • A nucleosome-like structure containing DNA and the arginine-rich histones H3 and H4, , Nucleic acids research, 1977
  • UV-Laser Crosslinking of Proteins to DNA, Daniel Houde, Stefan I. Dimitrov, Tom Moss, Methods, 1997, 10.1006/meth.1996.0409
  • The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation, , Nucleic acids research, 2012
  • The putative promoter of a Xenopus laevis ribosomal gene is reduplicated, , Nucleic acids research, 1979
  • DNase I Footprinting, Tom Moss, Benoît Leblanc, Nucleic Acid Protocols Handbook, The, 1911, 10.1385/1-59259-038-1:729
  • Mapping of a sequence essential for the nuclear transport of the Xenopus ribosomal transcription factor xUBF using a simple coupled translation-transport and acid extraction approach, , DNA and cell biology, 1993
  • Sites of Histone/Histone Interaction in the H3˙ H4 Complex, , European Journal of Biochemistry, 1977
  • A transcriptional function for repetitive ribosomal spacers in Xenopus?(reply), , Nature, 1983
  • The structural and architectural role of upstream binding factor, UBF, , Transcription of ribosomal genes by eukaryotic RNA polymerase I. Austin: Landes Bioscience, 1998
  • THE MAGAZINE-NEWS-Ribosomal genes and cell growth, , Medecine Sciences, 2002
  • Spacer promoters are essential for efficient enhancement of X. laevis ribosomal transcription, , Cell, 1986
  • The catalytic domain of xPAK1 is sufficient to induce myosin II dependent in vivo cell fragmentation independently of other apoptotic events, , Developmental biology, 2003
  • EphA4 signaling suppresses Cdc42 and RhoA activities by recruiting Pak1 in order to regulate blastomere association in the Xenopus blastula embryo., , DEVELOPMENTAL BIOLOGY, 2005
  • A ribosomal orphon sequence from Xenopus laevis flanked by novel low copy number repetitive elements, , Biological chemistry, 1999
  • Inactivation of topoisomerase I or II may lead to recombination or to aberrant replication termination on both SV40 and yeast 2 $μ$m DNA, , Chromosoma, 1996
  • The enhancement of ribosomal transcription by the recycling of RNA polymerase I, Tom Moss, Keith Mitchelson, Nucleic Acids Research, 1987, 10.1093/nar/15.22.9577
  • Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body, , PLoS Genetics, 2014
  • Transcription of cloned Xenopus laevis ribosomal DNA microinjected into Xenopus oocytes, and the identification of an RNA polymerase I promoter, , Cell, 1982
  • DNA looping in the RNA polymerase I enhancesome is the result of non-cooperative in-phase bending by two UBF molecules, , Nucleic acids research, 2001
  • Role of p21-activated kinase in cell polarity and directional mesendoderm migration in the Xenopus gastrula, , Developmental dynamics, 2009
  • DNase I footprinting, , DNA-Protein Interactions, 1994
  • High-resolution proton-magnetic-resonance studies of chromatin core particles [calf thymus], , European Journal of Biochemistry (Germany, FR), 1978
  • The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans, Engel C, Rudack T, Bruckmann A, Fürtges T, Mars J, Tlučková K, Ramsay E, Abascal-Palacios G, Heiss F, Höcherl M, Bleckmann A, Straub K, Pilsl M, Daiß J, Life science alliance, 2022
  • At the crossroads of growth control; making ribosomal RNA, , Current opinion in genetics & development, 2004
  • Extended Synaptotagmin Interaction with the Fibroblast Growth Factor Receptor Depends on Receptor Conformation, Not Catalytic Activity, Tom Moss, Sabrina Bellenfant, Joëlle Baril, Prakash K. Mishra, François Guillou, Chelsea Herdman, Michel G. Tremblay, Journal of Biological Chemistry, 2015, 10.1074/jbc.M115.656918
  • Point mutation analysis of the Xenopus laevis RNA polymerase I core promoter, , Nucleic acids research, 1990
  • Promotion and regulation of ribosomal transcription in eukaryotes by RNA polymerase 1, , Progress Nucl Acid Res Mol Biol, 1995
  • UV laser-induced protein-DNA crosslinking, , DNA-Protein Interactions, 1994
  • Spacer promoters are essential for efficient enhancement of X. laevis ribosomal transcription, Tom Moss, Ronald F.J. De Winter, Cell, 1986, 10.1016/0092-8674(86)90765-8
  • Extended-Synaptotagmins (E-Syts); the extended story, Tom Moss, Chelsea Herdman, Pharmacological Research, 2016, 10.1016/j.phrs.2016.01.034
  • Nucleosomes, histone interactions, and the role of histones H3 and H4, , Cold Spring Harbor symposia on quantitative biology, 1978
  • Control of ribosomal RNA synthesis by hematopoietic transcription factors., Paralkar VR, Pimkin M, Ganley ARD, Wilusz JE, Tan K, Moss T, Tremblay MG, Lv K, Gao L, Ai Y, Wu-Corts DJ, Thorsheim CL, Somers P, Blum J, George SS, Antony C, Molecular cell, 2022, 10.1016/j.molcel.2022.08.027
  • Gènes ribosomiques et régulation de la croissance cellulaire, , Le Magazine: Nouvelles, 2002
  • The structure and function of the ribosomal gene spacer, , The nucleolus. Cambridge University Press, Cambridge, 1982
  • Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility, Tom Moss, Michel G. Tremblay, Cell Cycle, 2016, 10.1080/15384101.2016.1203494
  • DNase I footprinting, , DNA-Protein Interactions, 2001
  • METHOD TO FACILITATE BASE SEQUENCING OF HIGHLY REPETITIVE DNA, , EXPERIENTIA, 1978
  • DNA tailing without terminal transferase, Tom Moss, Christine Dutta, Nucleic Acids Research, 1988, 10.1093/nar/16.15.7744
  • THE STRUCTURE OF THE XUBF-DNA COMPLEX, , JOURNAL OF CELLULAR BIOCHEMISTRY, 1994
  • More ribosomal spacer sequences from Xenopus laevis, Max L. Birnsteil, Paul G. Boseley, Tom Moss, Nucleic Acids Research, 1980, 10.1093/nar/8.3.467
  • DNA-protein Interactions, , 2001
  • The role of acetylation in rDNA transcription., , FASEB JOURNAL, 2000
  • At the Center of Eukaryotic Life, Victor Y. Stefanovsky, Tom Moss, Cell, 2002, 10.1016/s0092-8674(02)00761-4
  • SEQUENCE-ANALYSIS SUGGESTS A POSSIBLE FUNCTION FOR THE RIBOSOMAL SPACER DNA OF XENOPUS-LAEVIS, , Experientia, 1979
  • At the center of eukaryotic life, , Cell, 2002
  • The Xenopus laevis ribosomal gene terminator contains sequences that both enhance and repress ribosomal transcription., , Molecular and cellular biology, 1989
  • The promotion of ribosomal transcription in eukaryotes., , Oxford surveys on eukaryotic genes, 1985
  • mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF†, , Molecular and cellular biology, 2003
  • The p21-activated kinase Pak1 regulates induction and migration of the neural crest in Xenopus, , Cell cycle, 2012
  • TTF1 control of LncRNA synthesis and cell growth delineates a tumour suppressor pathway acting directly on the ribosomal RNA Genes, Tom Moss, Mark D. Robinson, Marianne Sabourin-Félix, Christophe Tav, Frédéric Lessard, Michel G. Tremblay, Dany S. Sibai, 2024, 10.1101/2024.02.11.579707
  • CELL GROWTH AND DEVELOPMENT-mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar, , Molecular and Cellular Biology, 2003
  • Enzymatic removal of vitelline membrane and other protocol modifications for whole mount in situ hybridization of Xenopus embryos, , Trends in Genetics, 1996
  • The cytoskeletal effector xPAK1 is expressed during both ear and lateral line development in Xenopus, , INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2000
  • Recognition of the Xenopus ribosomal core promoter by the transcription factor xUBF involves multiple HMG box domains and leads to an xUBF interdomain interaction., , The EMBO journal, 1993

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Abdelatif Nourdine Hamdane - Doctorat - 2015/01
  • Prakash Kumar Mishra - Doctorat - 2015/05
  • Chelsea Herdman - Maîtrise avec mémoire - 2015/05
  • Jean-Clement Mars - Doctorat - 2019/01
  • Dany Sibai - Doctorat - 2024/01

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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