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Véronique Moulin

Professeure titulaire

Véronique Moulin
veronique.moulin@fmed.ulaval.ca
Centre de recherche en arthrite (ARThrite)
Centre de recherche en organogenèse expérimentale
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
  • Peau
  • Fibroses
  • Affections cutanées
  • Maladies des tissus conjonctifs
  • Tissu conjonctif

Projets de recherche

  • The implication of PlGF in cutaneous fibrosis - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-10-01 au 2027-09-30
  • Real World Clinical and Economic Burden of Severe Burn Injuries - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-10-01 au 2026-09-30
  • Tissue engineering to treat Canadian burn patients: the Self-Assembled Skin Substitutes (SASS) - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), chercheur principal - 2022-04-01 au 2025-03-31
  • Allogeneic dermis to accelerate the production of a tissue-engineered skin substitute to treat Canadian burn patients - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), chercheur principal - 2023-04-01 au 2025-01-31
  • Cryo-TEM infrastructure for the visualisation of nanoparticles, exosomes and virus-like particles - Conseil de recherches en sciences naturelles et génie Canada - Subventions d'outils et d'instruments de recherche (OIR), co-chercheur - 2023-04-01 au 2024-03-31
  • Combining tissue-engineered skin with ex vivo gene therapy correction to develop a treatment for epidermolysis bullosa - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), co-chercheur - 2022-04-01 au 2024-03-31
  • Action des microvésicules dans les tissus solides - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2019-04-01 au 2024-03-31
  • Setting up the conditions for the biobanking of tissues and cells from hypertrophic scars - Instituts de recherche en santé du Canada - Subventions Catalyseur de réseaux, University of Toronto, co-chercheur - 2022-12-01 au 2023-11-30
  • La réponse immunitaire aux peaux reconstruites avec des cellules allogéniques. - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, co-chercheur - 2022-04-01 au 2023-03-31
  • Mise au point par génie tissulaire d'un modèle de cicatrisation cutanée contenant des cellules immunitaires - MITACS Inc. - Accélération Québec (MITACS et gouvernement provincial), chercheur principal - 2019-01-27 au 2023-02-28
  • The implication of PlGF in cutaneous fibrosis - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-03-01 au 2023-02-28
  • Self-Assembly Skin Substitutes (SASS) for the treatment of acute wounds of Canadian burn patients - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), chercheur principal - 2020-01-01 au 2022-01-31
  • Centre du génie tissulaire (CHU de Québec - Université Laval) - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, chercheur principal - 2019-04-01 au 2021-03-31
  • Bioengineering and Long-term Storage of Complex Tissue and Organ Constructs - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, Université d'Ottawa, co-chercheur - 2020-03-31 au 2021-03-31

Publications

  • The Self-Assembled Skin Substitute History: Successes, Challenges, and Current Treatment Indications, Véronique J Moulin, Lucie Germain, François A Auger, Charles Arcand, Jason Dagher, Journal of Burn Care & Research, 2023, 10.1093/jbcr/irac074
  • Morphological changes of human skin cells exposed to a DC electric field In vitro using a new exposure system, Germain, L., Auger, F.A., Plante, M., Goulet, D., Bourdages, M., Rancourt, D., Moulin, V., Méthot, S., Canadian Journal of Chemical Engineering, 2001, 10.1002/cjce.5450790428
  • Human keratinocytes respond to direct current stimulation by increasing intracellular calcium: Preferential response of poorly differentiated cells, Germain, L., Moulin, V.J., Plante, M., Bourdages, M., Goulet, D., Auger, F.A., Roberge, C.J., Gauvin, R., Lévesque, P., Rochette-Drouin, O., Dubé, J., Journal of Cellular Physiology, 2012, 10.1002/jcp.23008
  • Evaluation of contractile phenotype in airway smooth muscle cells isolated from endobronchial biopsy and tissue specimens from horses, Lavoie, J.-P., Goulet, F., Moulin, V., Lefebvre-Lavoie, J., Dubé, J., Peltier, A., Vargas, A., American Journal of Veterinary Research, 2017, 10.2460/ajvr.78.3.359
  • Optimization of a cutaneous wound-healing model for the screening of pharmaceutical compounds, Moulin, V., Auger, F.A., Germain, L., Laplante, A.F., Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling, 2000
  • Apoptosis modulation as a promising target for treatment of systemic sclerosis, Moulin, V.J., Chabaud, S., International Journal of Rheumatology, 2011, 10.1155/2011/495792
  • Platelet releasate treatment improves skin healing in diabetic rats through endogenous growth factor secretion., Caruelle, J.P., Barritault, D., Lawny, F., Moulin, V., Cellular and molecular biology (Noisy-le-Grand, France), 1998
  • Extracellular vesicles on the move: Traversing the complex matrix of tissues, Véronique J. Moulin, Syrine Arif, European Journal of Cell Biology, 2023, 10.1016/j.ejcb.2023.151372
  • Decreased secretion of MMP by non-lesional late-stage scleroderma fibroblasts after selection via activation of the apoptotic fas-pathway, Moulin, V.J., Raymond, Y., Chartier, S., Senécal, J.-L., Grodzicky, T., Corriveau, M.-P., Chabaud, S., Journal of Cellular Physiology, 2011, 10.1002/jcp.22520
  • Pro-angiogenic capacities of microvesicles produced by skin wound myofibroblasts, Moulin, V.J., Ricard-Blum, S., Cloutier, C.B., Larochelle, S., Langlois, A., Merjaneh, M., Angiogenesis, 2017, 10.1007/s10456-017-9554-9
  • Shedding of proangiogenic microvesicles from hypertrophic scar myofibroblasts, Véronique J. Moulin, Sébastien Larochelle, Syrine Arif, Mays Merjaneh, Alexandra Laberge, Experimental Dermatology, 2021, 10.1111/exd.14178
  • Role of seaweed laminaran from Saccharina longicruris on matrix deposition during dermal tissue-engineered production, Moulin, V.J., Beaulieu, M., Turgeon, S.L., Rioux, L.-E., Pereira, J.M., Ayoub, A., International Journal of Biological Macromolecules, 2015, 10.1016/j.ijbiomac.2015.01.017
  • Autologous bilayered self-assembled skin substitutes (Sasss) as permanent grafts: A case series of 14 severely burned patients indicating clinical effectiveness, Auger, F.A., Moulin, V.J., Knoppers, B.M., Bernier, V., Nguyen, M.T., Lee, J., Leclerc, Y., Kanevsky, J., Boghossian, E., Bussière, A., Dumas, A., Caouette-Laberge, L., Genest, H., Cloutier, C.B., Bortoluzzi, P., Duranceau, L., Perreault, I., Nedelec, B., Larouche, D., Germain, L., European Cells and Materials, 2018, 10.22203/eCM.v036a10
  • Mechanisms of wound reepithelialization: Hints from a tissue-engineered reconstructed skin to long-standing questions, Moulin, V., Auger, F.A., Germain, L., Laplante, A.F., FASEB Journal, 2001, 10.1096/fj.01-0250com
  • Expression of heat shock proteins in mouse skin during wound healing, Germain, L., Tanguay, R.M., Morrow, G., Li, H., Landry, J., Auger, F.A., Moulin, V., Laplante, A.F., Journal of Histochemistry and Cytochemistry, 1998, 10.1177/002215549804601109
  • Microvesicles: Intercellular messengers in cutaneous wound healing, Véronique J. Moulin, Syrine Arif, Alexandra Laberge, Journal of Cellular Physiology, 2018, 10.1002/jcp.26426
  • Improved Methods to Produce Tissue-Engineered Skin Substitutes Suitable for the Permanent Closure of Full-Thickness Skin Injuries, Germain, L., Moulin, V.J., Auger, F.A., Gauvin, R., Lavoie, A., Ayoub, A., Martel, I., Guignard, R., Desgagné, M., Cantin-Warren, L., Larouche, D., BioResearch Open Access, 2016, 10.1089/biores.2016.0036
  • α‐2‐Macroglobulin induces the shedding of microvesicles from cutaneous wound myofibroblasts, Véronique J. Moulin, Alain Garnier, Sébastien Larochelle, Syrine Arif, Akram Ayoub, Alexandra Laberge, Journal of Cellular Physiology, 2019, 10.1002/jcp.27794
  • Granulation tissue myofibroblasts during normal and pathological skin healing: The interaction between their secretome and the microenvironment, Véronique J. Moulin, Emilie Attiogbe, Syrine Arif, Wound Repair and Regeneration, 2021, 10.1111/wrr.12919
  • Microvesicles derived from dermal myofibroblasts modify the integrity of the blood and lymphatic barriers using distinct endocytosis pathways, Véronique J. Moulin, Sébastien Larochelle, Megan Richer, Syrine Arif, Journal of Extracellular Biology, 2024, 10.1002/jex2.151
  • Sensitivity of myofibroblasts to H2O2-mediated apoptosis and their antioxidant cell network, Moulin, V., Roy, M., Lopez-Vallé, C.A., Thibault, I., Langlois, C., Larochelle, S., Journal of Cellular Physiology, 2004, 10.1002/jcp.20003
  • Differential expression of collagen integrin receptor on fetal vs. adult skin fibroblasts: Implication in wound contraction during healing, Plamondon, M., Moulin, V., British Journal of Dermatology, 2002, 10.1046/j.1365-2133.2002.04975.x
  • Fetal and adult human skin fibroblasts display intrinsic differences in contractile capacity, Germain, L., Philip, A., O'Connor-McCourt, M.D., Auger, F.A., Castilloux, G., Tam, B.Y.Y., Moulin, V., Journal of Cellular Physiology, 2001, 10.1002/jcp.1110
  • Growth factors in skin wound healing, Moulin, V., European Journal of Cell Biology, 1995
  • Tissue-engineered skin substitutes: From in vitro constructs to in vivo applications, Germain, L., Pouliot, R., Moulin, V., Berthod, F., Auger, F.A., Biotechnology and Applied Biochemistry, 2004
  • Fetal and postnatal sera differentially modulate human dermal fibroblast phenotypic and functional features in vitro, Germain, L., O'Connor-McCourt, M., Auger, F.A., Moulin, V., Journal of Cellular Physiology, 1997, 10.1002/(SICI)1097-4652(199704)171:1<1::AID-JCP1>3.0.CO;2-S
  • Enhanced secretion of TIMP-1 by human hypertrophic scar keratinocytes could contribute to fibrosis, Moulin, V.J., Armour, A., Genest, H., Lopez-Vallé, C.A., Larochelle, S., Bergeron, D., Simon, F., Burns, 2012, 10.1016/j.burns.2011.09.001
  • Angiogenic properties of myofibroblasts isolated from normal human skin wounds, Moulin, V.J., Roy, M., Genest, H., Langlois, A., Laforce-Lavoie, A., Larochelle, S., Mayrand, D., Angiogenesis, 2012, 10.1007/s10456-012-9253-5
  • The fibrotic phenotype of systemic sclerosis fibroblasts varies with disease duration and severity of skin involvement: Reconstitution of skin fibrosis development using a tissue engineering approach, Moulin, V.J., Raymond, Y., Chartier, S., Grodzicky, T., Senécal, J.-L., Chabaud, S., Lessard, J., Boufaied, I., Corriveau, M.-P., Journal of Pathology, 2009, 10.1002/path.2482
  • Role of wound healing myofibroblasts on re-epithelialization of human skin, Germain, L., Garrel, D., Auger, F.A., Moulin, V., Burns, 2000, 10.1016/S0305-4179(99)00091-1
  • Normal Skin Wound and Hypertrophic Scar Myofibroblasts Have Differential Responses to Apoptotic Inductors, Roy, M., Lopez-Vallé, C.A., Thibault, I., Langlois, C., Larochelle, S., Moulin, V., Journal of Cellular Physiology, 2004, 10.1002/jcp.10415
  • In vitro models to study wound healing fibroblasts, Germain, L., Auger, F.A., Garrel, D.R., Jean, A., Castilloux, G., Moulin, V., Burns, 1996, 10.1016/0305-4179(95)00167-0
  • Reconstitution of skin fibrosis development using a tissue engineering approach, Moulin, V.J., Methods in Molecular Biology, 2013, 10.1007/978-1-62703-227-8_19
  • Anticancer properties of chitosan on human melanoma are cell line dependent, Moulin, V.J., Auger, F.A., Bolduc, S., Bouhout, S., Chabaud, S., Gibot, L., International Journal of Biological Macromolecules, 2015, 10.1016/j.ijbiomac.2014.08.033
  • Engineering human tissues for in vivo applications, Auger, F.A., Berthod, F., Moulin, V., Goulet, F., Germain, L., Annals of the New York Academy of Sciences, 2002, 10.1111/j.1749-6632.2002.tb03099.x
  • Modulated response to cytokines of human wound healing myofibroblasts compared to dermal fibroblasts, Germain, L., O'Connor-McCourt, M.D., Garrel, D., Auger, F.A., Castilloux, G., Moulin, V., Experimental Cell Research, 1998, 10.1006/excr.1997.3827
  • An in vitro autologous, vascularized, and immunocompetent Tissue Engineered Skin model obtained by the self-assembled approach, Véronique J Moulin, Caroline Gilbert, Brigitte Closs, Sylvie Bordes, Adèle Mauroux, Carine Mainzer, Yanis Chaib, Sébastien Larochelle, Emilie Attiogbe, Acta Biomaterialia, 2023, 10.1016/j.actbio.2023.06.045
  • Epidermis promotes dermal fibrosis: Role in the pathogenesis of hypertrophic scars, Moulin, V.J., Roy, M., Lopez-Vallé, C.A., Bergeron, D., Roberge, C.J., Bellemare, J., Journal of Pathology, 2005, 10.1002/path.1737
  • Translating the combination of gene therapy and tissue engineering for treating recessive dystrophic epidermolysis bullosa, Germain, L., Caruso, M., Moulin, V.J., Larochelle, S., Ghio, S.C., Bisson, F., Ghani, K., Larouche, D., Piaceski, A.D., European Cells and Materials, 2018, 10.22203/eCM.v035a06
  • GPR43 regulates sodium butyrate-induced angiogenesis and matrix remodeling, Lucíola Silva Barcelos, Véronique J. Moulin, Mark Slevin, Charles Reay Mackay, Silvia Passos Andrade, Sébastien Larochelle, Lucas Felipe Fernandes Bittencourt, Pollyana Ribeiro Castro, American Journal of Physiology-Heart and Circulatory Physiology, 2021, 10.1152/ajpheart.00515.2019
  • PLGF-1 contained in normal wound myofibroblast-derived microvesicles stimulated collagen production by dermal fibroblasts, Véronique J. Moulin, Sébastien Larochelle, Syrine Arif, Journal of Cell Communication and Signaling, 2020, 10.1007/s12079-020-00572-5
  • Human skin fibroblast response is differentially regulated by galactofucan and low molecular weight galactofucan, Turgeon, S.L., Beaulieu, M., Moulin, V., Rioux, L.-E., Bioactive Carbohydrates and Dietary Fibre, 2013, 10.1016/j.bcdf.2013.03.004
  • Enhancing repair of full-thickness excisional wounds in a murine model: Impact of tissue-engineered biological dressings featuring human differentiated adipocytes, Fradette, J., Moulin, V.J., Gagné, V.L., Mayrand, D., Laterreur, V., Maux, A., Morissette Martin, P., Acta Biomaterialia, 2015, 10.1016/j.actbio.2015.04.036
  • Tissue-engineered human asthmatic bronchial equivalents, Bongrand, P., Qvortrup, K., Goulet, F., Boulet, L.-P., Auger, F.A., Laviolette, M., Boutet, M., Bernier, V., Tremblay, P., Moulin, V., Paquette, J.-S., European Cells and Materials, 2004, 10.22203/eCM.v007a01
  • Characterization of epidermal lipoxygenase expression in normal human skin and tissue-engineered skin substitutes, De Laclos, B.F., Moulin, V.J., Parent, L.A., Simard-Bisson, C., Journal of Histochemistry and Cytochemistry, 2018, 10.1369/0022155418788117
  • The diffusion of normal skin wound myofibroblast‐derived microvesicles differs according to matrix composition, Véronique J. Moulin, Alain R. Brisson, François Bordeleau, Céline Gounou, Benjamin Trudel, Sébastien Larochelle, Syrine Arif, Journal of Extracellular Biology, 2024, 10.1002/jex2.131
  • Prospective study on the treatment of lower-extremity chronic venous and mixed ulcers using tissue-engineered skin substitute made by the self-assembly approach, Auger, F.A., Germain, L., Moulin, V.J., Larouche, D., Rochon, M.-H., Dubé, N., Ospina, C.E., Arsenault, F., Roy, M., Soucy, J., Rodrigue, B., Labbé, R., Genest, H., Cloutier, C.B., Boa, O., Advances in Skin and Wound Care, 2013, 10.1097/01.ASW.0000433102.48268.2a
  • In Vivo Evaluation and Imaging of a Bilayered Self-Assembled Skin Substitute Using a Decellularized Dermal Matrix Grafted on Mice, Auger, F.A., Gauvin, R., Germain, L., Moulin, V.J., Larouche, D., Guignard, R., Perron, C., Goyer, B., Beaudoin Cloutier, C., Tissue Engineering - Part A, 2017, 10.1089/ten.tea.2016.0296
  • Biofabrication and preclinical evaluation of a large-sized human self-assembled skin substitute, Veronique J Moulin, Francois A Auger, Lucie Germain, Emilie Attiogbe, Akram Ayoub, Dominique Mayrand, Fabien Kawecki, Biomedical Materials, 2020, 10.1088/1748-605X/abbdbe
  • Production of a Bilayered Self-Assembled Skin Substitute Using a Tissue-Engineered Acellular Dermal Matrix, Auger, F.A., Germain, L., Moulin, V.J., Lacroix, D., Lavoie, A., Larouche, D., Gauvin, R., Bernard, G., Guignard, R., Beaudoin Cloutier, C., Tissue Engineering - Part C: Methods, 2015, 10.1089/ten.tec.2015.0258
  • Tissue engineering: A tool to understand the physiological mechanisms,Le génie tissulaire au service de la compréhension du vivant, Auger, F.A., Germain, L., Berthod, F., Goulet, F., Moulin, V., Medecine/Sciences, 2003
  • New ligament healing model based on tissue-engineered collagen scaffolds, Goulet, F., Islam, N., Simon, F., Chabaud, S., Larkin, A.-M., Lamontagne, J., Cloutier, R., Tremblay, P., Moulin, V.J., Robayo, L.M., Wound Repair and Regeneration, 2011, 10.1111/j.1524-475X.2010.00640.x
  • What's new in human wound-healing myofibroblasts?, Germain, L., Castilloux, G., O'Connor-McCourt, M., Auger, F.A., Garrel, D., Moulin, V., Current topics in pathology. Ergebnisse der Pathologie, 1999
  • The Role of Microvesicles in Cutaneous Wound Healing, Moulin, V.J., Laberge, A., Wound Healing: Stem Cells Repair and Restorations, Basic and Clinical Aspects, 2018, 10.1002/9781119282518.ch4
  • Shedding of microparticles by myofibroblasts as mediator of cellular cross-talk during normal wound healing, Genest, H., Lopez-Vallé, C.A., Martinez, M.C., Messier, H., Mayrand, D., Moulin, V.J., Journal of Cellular Physiology, 2010, 10.1002/jcp.22268
  • The role of myofibroblasts in normal skin wound healing, Moulin, V.J., Myofibroblasts: Origin, Function and Role in Disease, 2016
  • Restoration of the transepithelial potential within tissue-engineered human skin in vitro and during the wound healing process in vivo, Moulin, V.J., Germain, L., Plante, M., Bourdages, M., Goulet, D., Auger, F.A., Roberge, C.J., Gauvin, R., Lévesque, P., Rochette-Drouin, O., Dubé, J., Tissue Engineering - Part A, 2010, 10.1089/ten.tea.2010.0030
  • Tissue-engineered human skin substitutes developed from collagen-populated hydrated gels: Clinical and fundamental applications, Germain, L., Moulin, V., Berthod, F., Goulet, F., Rouabhia, M., Auger, F.A., Medical and Biological Engineering and Computing, 1998, 10.1007/BF02518887

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Elodie Mareux - Post-doctorat - En cours
  • Rachel Caya - Maîtrise avec mémoire - En cours
  • Elnaz Salekzamani - Maîtrise avec mémoire - 2013/09
  • Amélie Langlois - Maîtrise avec mémoire - 2013/09
  • Akram Ayoub - Maîtrise avec mémoire - 2014/05
  • Pascal Morissette Martin - Maîtrise avec mémoire - 2015/01
  • Alexandra Laberge - Maîtrise avec mémoire - 2019/09
  • Yanis Chaib - Maîtrise avec mémoire - 2020/01
  • Maude Vaillancourt-Audet - Maîtrise avec mémoire - 2020/01
  • Charles Arcand - Maîtrise avec mémoire - 2024/01

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Microbiologie-immunologie
  • Sciences cliniques et biomédicales

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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