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Yannick Doyon

Professeur titulaire

Yannick Doyon
yannick.doyon.1@ulaval.ca
Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire

Domaines de recherche :

Thérapie génique et moléculaire
Génie moléculaire médical des acides nucléiques et des protéines
Thérapeutique et mise au point de médicaments contre le cancer
Génie génétique
Cibles moléculaires du cancer
Autres médecine fondamentale et sciences de la vie
Médecine régénérative (y compris les cellules souches et le génie tissulaire)

Projets de recherche en cours

  • Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines - Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université du Québec à Montréal - UQAM , co-chercheur - 2024-04-01 au 2030-03-31
  • In vivo genome editing for inborn errors of metabolism - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2025-04-01 au 2030-03-31
  • Correction génétique de la tyrosinémie héréditaire de type 1 chez la souris par ingénierie ciblée du génome - Fondation du Grand défi Pierre Lavoie, chercheur principal - 2024-10-01 au 2025-09-30

Financements des 2 dernières années

  • Orthologous CRISPR-Cas9 systems for genome editing: discovery, characterization and development for novel biotechnological applications - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-10-01 au 2024-09-30
  • Rewiring the Metabolic Ecosystem to Improve Cellular Immunotherapy - Instituts de recherche en santé du Canada - Subvention Projet, University of Victoria, co-chercheur - 2019-04-01 au 2024-03-31
  • Utilisation des nouvelles technologies d'édition du génome et de séquençage pour améliorer la sécurité des transfusions sanguines - MITACS Inc. - Accélération-Élévation, chercheur principal - 2019-11-01 au 2024-02-01
  • Metabolic Gene-Edited CAR-T Cells For Ovarian Cancer Treatment - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), University of Victoria, co-chercheur - 2021-07-15 au 2023-07-14

Publications

  • In vivo genome editing of the albumin locus as a platform for protein replacement therapy, High, K.A., Rebar, E.J., Holmes, M.C., Gregory, P.D., Rieders, J., Zhou, S., Shivak, D., Davidson, R.J., Miller, J.C., Paschon, D.E., Sproul, S., DeKelver, R.C., Wechsler, T., Doyon, Y., Anguela, X.M., Sharma, R., Blood, 2015, 10.1182/blood-2014-12-615492
  • Robust ZFN-mediated genome editing in adult hemophilic mice, High, K.A., Holmes, M.C., Gregory, P.D., Zhou, S., Davidson, R.J., Wong, S.Y., Rohde, M.E., Haurigot, V., Li, H., Miller, J.C., Doyon, Y., Sharma, R., Anguela, X.M., Blood, 2013, 10.1182/blood-2013-04-497354
  • Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells, Drubin, D.G., Urnov, F.D., Gregory, P.D., Rebar, E.J., Zhang, L., Paschon, D.E., Miller, J.C., Doyon, Y., Vo, T.D., Lee, A.H., Santiago, Y., Cherone, J.M., Cheng, A.T., Cheng, J., Zeitler, B., Doyon, J.B., Nature Cell Biology, 2011, 10.1038/ncb2175
  • A Scalable Genome-Editing-Based Approach for Mapping Multiprotein Complexes in Human Cells, Doyon, Y., Côté, J., Herst, P., Roques, C., Huard, C.C., Jacquet, K., Loehr, J., Dalvai, M., Cell Reports, 2015, 10.1016/j.celrep.2015.09.009
  • The highly conserved and multifunctional NuA4 HAT complex, Côté, J., Doyon, Y., Current Opinion in Genetics and Development, 2004, 10.1016/j.gde.2004.02.009
  • HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail, Côté, J., Kutateladze, T.G., Gozani, O., Yang, X.-J., Côté, V., Landry, A.-J., Ullah, M., Paquet, E., Cayrou, C., Doyon, Y., Hung, T., Champagne, K.S., Avvakumov, N., Saksouk, N., Molecular Cell, 2009, 10.1016/j.molcel.2009.01.007
  • Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans, Côté, J., Tan, S., Lane, W.S., Selleck, W., Doyon, Y., Molecular and Cellular Biology, 2004, 10.1128/MCB.24.5.1884-1896.2004
  • Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases, Zeitler, B., Harland, R.M., Urnov, F.D., Gregory, P.D., Rebar, E.J., Zhang, L., Miller, J.C., Paschon, D.E., Guschin, D.Y., Ngo, C., Lee, A.H., Faraji, F.M., Ankoudinova, I., Doyon, Y., Cherone, J.M., Young, J.J., Proceedings of the National Academy of Sciences of the United States of America, 2011, 10.1073/pnas.1102030108
  • ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation, Côté, J., Yang, X.-J., Tan, S., Lane, W.S., Selleck, W., Côté, V., Landry, A.-J., Ullah, M., Cayrou, C., Doyon, Y., Molecular Cell, 2006, 10.1016/j.molcel.2005.12.007
  • Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins, Sylvain Moineau, Christian Cambillau, Yannick Doyon, Philippe Horvath, Christophe Fremaux, Dennis A. Romero, Jeremy Loehr, Beatrice Amigues, Adeline Goulet, Daniel Agudelo, Geneviève M. Rousseau, Alexander P. Hynes, Nature Communications, 2018, 10.1038/s41467-018-05092-w
  • Preparation and Analysis of Native Chromatin-Modifying Complexes, Côté, J., Doyon, Y., Methods in Enzymology, 2016, 10.1016/bs.mie.2016.01.017
  • Eaf1 Is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants, Côté, J., Allard, S., Cronier, D., Utley, R.T., Doyon, Y., Nourani, A., Altaf, M., Galarneau, L., Auger, A., Molecular and Cellular Biology, 2008, 10.1128/MCB.01755-07
  • Mystification and cleverness of tumor suppressors in nuclear functions | La mystification et l'ingéniosité de suppresseurs de tumeurs dans les fonctions nucléaires., Côté, J., Côté, V., Landry, A.J., Doyon, Y., Cayrou, C., Médecine sciences : M/S, 2006
  • Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci., Jacques Cote, Doyon Y, Taipale M, Droit A, Benoit Coulombe, Gingras AC, Rouzbahman M, Bernardini MQ, Loehr J, Thonta Setty S, Lara Herrmann, Paquet E, Lachance C, Rousseau J, Lambert JP, Amel Mameri, Jacquet K, Joly-Beauparlant C, Alerasool N, Lalonde ME, Avvakumov N, Sudarshan D, Genes & development, 2022, 10.1101/gad.348982.121
  • Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes, Yang, X.-J., Côté, J., Champagne, N., Goh, S.-L., Doyon, Y., Cayrou, C., Tahmasebi, S., Degerny, C., Wang, K., Song, P.Z., Xiao, L., Pelletier, N., Ullah, M., Molecular and Cellular Biology, 2008, 10.1128/MCB.01297-08
  • Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation, Côté, J., Kutateladze, T.G., Yang, X.-J., Richard, D.E., Robitaille, G.A., Cayrou, C., Doyon, Y., Landry, A.-J., Glass, K.C., Paquet, E., Saksouk, N., Lalonde, M.-E., Avvakumov, N., Molecular and Cellular Biology, 2012, 10.1128/MCB.06455-11
  • Accessory-cell-free differentiation of hematopoietic stem and progenitor cells into mature red blood cells, Josée Laganière, Yannick Doyon, Nellie Dumont, Yelena Boccacci, 2022, 10.1101/2022.09.14.507311
  • Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme, Holmes, M.C., Gregory, P.D., Babiarz, J.E., Yan, J.J., Hua, K.L., Miller, J.C., Li, C.J., Wang, N.S., Doyon, Y., Friedman, G., Wang, J., Genome Research, 2012, 10.1101/gr.122879.111
  • Marker-free co-selection for successive rounds of prime editing in human cells, Yannick Doyon, Daniel Agudelo, Eva Bouchard, Andréanne Loiselle, Alexis Duringer, Claudia Goupil, Jean-Philippe Fiset, Diana Mayorga, Sébastien Levesque, Nature Communications, 2022, 10.1038/s41467-022-33669-z
  • Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex, Côté, J., Lane, W.S., Allard, S., Utley, R.T., Doyon, Y., Nourani, A., Molecular and Cellular Biology, 2001, 10.1128/MCB.21.22.7629-7640.2001
  • Accessory-cell-free differentiation of hematopoietic stem and progenitor cells into mature red blood cells, Josée Laganière, Yannick Doyon, Nellie Dumont, Yelena Boccacci, Cytotherapy, 2023, 10.1016/j.jcyt.2023.07.007
  • Cancer translocations in human cells induced by zinc finger and TALE nucleases, Brunet, E., Jasin, M., Giovannangeli, C., Concordet, J.-P., Doyon, Y., Holmes, M.C., Zhang, L., Katibah, G.E., René, O., Perrouault, L., Tomishima, M., Guittat, L., De Cian, A., Ghezraoui, H., Piganeau, M., Genome Research, 2013, 10.1101/gr.147314.112
  • Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6., , Molecular cell, 2019, 10.1016/j.molcel.2019.09.012
  • In vivodissection of the mouse tyrosine catabolic pathway with CRISPR-Cas9 identifies modifier genes affecting hereditary tyrosinemia type 1, Yannick Doyon, Massimiliano Paganelli, Paula J. Waters, Fabrice Mac-Way, Dorothée Dal Soglio, Roth-Visal Ung, Denis Cyr, Claudia Goupil, Sophie Carter, Jean-François Rivest, 2023, 10.1101/2023.09.29.559947
  • Precise genome modification in the crop species Zea mays using zinc-finger nucleases, Urnov, F.D., Gregory, P.D., Rebar, E.J., Zhang, L., Hinkley, S.J., Butler, H.J., Greenwalt, S.A., Blakeslee, B., Simpson, M.A., McCaskill, D., Zhifang, G., Katibah, G.E., Wu, Y.-Y., Rock, J.M., Choi, V.M., Meng, X., Gopalan, S., Arnold, N.L., Mitchell, J.C., Worden, S.E., Moehle, E.A., Dekelver, R.C., Miller, J.C., Doyon, Y., Shukla, V.K., Nature, 2009, 10.1038/nature07992
  • Identification and Analysis of Native HAT Complexes, Grant, P.A., Côté, J., Doyon, Y., McMahon, S.J., Methods in Enzymology, 2004, 10.1016/S0076-6879(03)77008-6
  • Gene therapy in tyrosinemia: Potential and pitfalls, Doyon, Y., Carter, S., Advances in Experimental Medicine and Biology, 2017, 10.1007/978-3-319-55780-9_21
  • Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases, Amacher, S.L., Urnov, F.D., Gregory, P.D., Rebar, E.J., Zhang, L., Hocking, T.D., Amora, R., Katibah, G.E., Ngo, C., Faraji, F., Miller, J.C., McCammon, J.M., Doyon, Y., Nature Biotechnology, 2008, 10.1038/nbt1409
  • In vivo genome editing restores haemostasis in a mouse model of haemophilia, High, K.A., Holmes, M.C., Gregory, P.D., Bushman, F.D., Rebar, E.J., Paschon, D.E., Zhou, S., Khazi, F.R., Finn, J.D., Murphy, S.L., Ivanciu, L., Sharma, R., Anguela, X.M., Malani, N., Bhagwat, A.S., Wong, S.Y., Li, T., Doyon, Y., Haurigot, V., Li, H., Nature, 2011, 10.1038/nature10177
  • Dairy phages escape CRISPR defence of Streptococcus thermophilus via the anti-CRISPR AcrIIA3., Moineau S, Doyon Y, Goulet A, Fiset JP, Levesque S, Somerville V, Rousseau GM, Adeline Pastuszka, International journal of food microbiology, 2023, 10.1016/j.ijfoodmicro.2023.110414
  • In vivo dissection of the mouse tyrosine catabolic pathway with CRISPR-Cas9 identifies modifier genes affecting hereditary tyrosinemia type 1., Yannick Doyon, Paganelli M, Paula Waters, Mac-Way F, Dal Soglio D, Ung RV, Cyr D, Antérieux P, Goupil C, Carter S, Jean-François Rivest, Genetics, 2024, 10.1093/genetics/iyae139
  • Targeted transgene integration in plant cells using designed zinc finger nucleases, Petolino, J.F., Urnov, F.D., Gregory, P.D., Rubin-Wilson, B., Collingwood, T.N., Rebar, E.J., Holmes, M.C., Zhang, L., Faraji, F., Baker, L., Worden, A., Blue, R., Schulenberg, L., Garrison, R., Lee, Y.-L., Rock, J.M., Moehle, E.A., DeKelver, R.C., Miller, J.C., Ainley, W.M., Doyon, Y., Cai, C.Q., Plant Molecular Biology, 2009, 10.1007/s11103-008-9449-7
  • Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9., , Genome research, 2020, 10.1101/gr.255414.119
  • The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation, Côté, J., Durocher, D., Doyon, Y., Legube, G., Pandita, T.K., Gingras, A.-C., Herst, P., Paquet, E., Pandita, R.K., Roques, C., Lambert, J.-P., Avvakumov, N., Fradet-Turcotte, A., Jacquet, K., Molecular Cell, 2016, 10.1016/j.molcel.2016.03.031
  • IL-1α gene deletion protects oligodendrocytes after spinal cord injury through upregulation of the survival factor Tox3, Lacroix, S., Doyon, Y., Tremblay, M.-È., Takashima, A., Champagne, M., Vallières, N., Lessard, M., Landete, V.B., Bastien, D., Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.0498-15.2015
  • Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures, Holmes, M.C., Gregory, P.D., Urnov, F.D., Miller, J.C., Xia, D.F., Wang, J., Greenberg, S.G., Mendel, M.C., Vo, T.D., Doyon, Y., Nature Methods, 2011, 10.1038/nmeth.1539
  • Transient cold shock enhances zinc-finger nuclease-mediated gene disruption, Holmes, M.C., Gregory, P.D., Vo, T.D., Xia, D.F., Choi, V.M., Doyon, Y., Nature Methods, 2010, 10.1038/nmeth.1456
  • Effect of C-domain N-glycosylation and deletion on rat pancreatic α-amylase secretion and activity, LeBel, D., Daull, P., Home, W., Doyon, Y., Biochemical Journal, 2002, 10.1042/0264-6021:3620259
  • Marker-free coselection for successive rounds of prime editing in human cells, Yannick Doyon, Daniel Agudelo, Eva Bouchard, Andréanne Loiselle, Alexis Duringer, Claudia Goupil, Jean-Philippe Fiset, Diana Mayorga, Sébastien Levesque, 2021, 10.1101/2021.11.02.464583
  • Marker-free coselection for CRISPR-driven genome editing in human cells, Doyon, Y., Laganière, J., Dellaire, G., Salsman, J., Drouin, M., Synodinou, D., Loehr, J., Carter, S., Huard, C.C., Bozoyan, L., Duringer, A., Agudelo, D., Nature Methods, 2017, 10.1038/nmeth.4265
  • CRISPR-Cas9-driven antigen conversion of clinically relevant blood group systems, Josee Laganiere, Yannick Doyon, Nellie Dumont, Yelena Boccacci, 2025, 10.1093/hmg/ddaf040
  • Rewired Cas9s with Minimal Sequence Constraints., , Trends in pharmacological sciences, 2020, 10.1016/j.tips.2020.04.009
  • Inducing high rates of targeted mutagenesis in zebrafish using zinc finger nucleases (ZFNs), Amacher, S.L., Doyon, Y., McCammon, J.M., Methods in Molecular Biology, 2011, 10.1007/978-1-61779-210-6_20
  • MTORas a selectable genomic harbor for CRISPR-engineered CAR-T cell therapy, Yannick Doyon, Julian J. Lum, Brian Boyle, Josée Laganière, Nellie Dumont, Geneviève Morin, Eric Normandeau, Sarah Villeneuve, Jean-Philippe Fiset, Claudia Goupil, Victoria Duque, Gillian Carleton, Sébastien Levesque, 2023, 10.1101/2023.09.14.557485

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/04
  • Pénélope Antérieux - Doctorat - En cours
  • Yelena Boccacci - Maîtrise avec mémoire - 2020/05
  • Daniel Agudelo - Doctorat - 2022/01
  • Sebastien Levesque - Doctorat - 2022/09
  • Simon-Alexandre Lafontaine Gosselin - Maîtrise avec mémoire - 2025/01

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Médecine moléculaire

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Disponibilité d'encadrement d'étudiant(e)s

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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