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Yannick Doyon

Professeur titulaire

Yannick Doyon
Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
Génétique humaine
  • Génome
  • Génomique
  • Maladies génétiques
  • Protéomique
  • Thérapie génique
Santé de la mère, des enfants et des adolescents

Projets de recherche

  • Regroupement Québécois de Recherche sur la Fonction, l’Ingénierie et les Applications des Protéines - Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université du Québec à Montréal - UQAM , co-chercheur - 2024-04-01 au 2030-03-31
  • Correction génétique de la tyrosinémie héréditaire de type 1 chez la souris par ingénierie ciblée du génome - Fondation du Grand défi Pierre Lavoie, chercheur principal - 2024-10-01 au 2025-09-30
  • Orthologous CRISPR-Cas9 systems for genome editing: discovery, characterization and development for novel biotechnological applications - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-10-01 au 2024-09-30
  • Rewiring the Metabolic Ecosystem to Improve Cellular Immunotherapy - Instituts de recherche en santé du Canada - Subvention Projet, University of Victoria, co-chercheur - 2019-04-01 au 2024-03-31
  • Utilisation des nouvelles technologies d'édition du génome et de séquençage pour améliorer la sécurité des transfusions sanguines - MITACS Inc. - Accélération-Élévation, chercheur principal - 2019-11-01 au 2024-02-01
  • Metabolic Gene-Edited CAR-T Cells For Ovarian Cancer Treatment - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), University of Victoria, co-chercheur - 2021-07-15 au 2023-07-14
  • Engineering, Cloning, Expression and Small Scale Purification of St1Cas9 and variants in Escherichia coli - Conseil national de recherches du Canada, chercheur principal - 2020-03-31 au 2023-03-31
  • Définir le potentiel thérapeutique et les mécanismes d’action de VSTM2A - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, co-chercheur - 2022-04-01 au 2023-03-31
  • Understanding the pathogenesis of COVID-19 - Instituts de recherche en santé du Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), co-chercheur - 2020-03-01 au 2021-02-28

Publications

  • Effect of C-domain N-glycosylation and deletion on rat pancreatic α-amylase secretion and activity, LeBel, D., Daull, P., Home, W., Doyon, Y., Biochemical Journal, 2002, 10.1042/0264-6021:3620259
  • Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes, Yang, X.-J., Côté, J., Champagne, N., Goh, S.-L., Doyon, Y., Cayrou, C., Tahmasebi, S., Degerny, C., Wang, K., Song, P.Z., Xiao, L., Pelletier, N., Ullah, M., Molecular and Cellular Biology, 2008, 10.1128/MCB.01297-08
  • Mystification and cleverness of tumor suppressors in nuclear functions | La mystification et l'ingéniosité de suppresseurs de tumeurs dans les fonctions nucléaires., Côté, J., Côté, V., Landry, A.J., Doyon, Y., Cayrou, C., Médecine sciences : M/S, 2006
  • MTORas a selectable genomic harbor for CRISPR-engineered CAR-T cell therapy, Yannick Doyon, Julian J. Lum, Brian Boyle, Josée Laganière, Nellie Dumont, Geneviève Morin, Eric Normandeau, Sarah Villeneuve, Jean-Philippe Fiset, Claudia Goupil, Victoria Duque, Gillian Carleton, Sébastien Levesque, 2023, 10.1101/2023.09.14.557485
  • Inducing high rates of targeted mutagenesis in zebrafish using zinc finger nucleases (ZFNs), Amacher, S.L., Doyon, Y., McCammon, J.M., Methods in Molecular Biology, 2011, 10.1007/978-1-61779-210-6_20
  • The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation, Côté, J., Durocher, D., Doyon, Y., Legube, G., Pandita, T.K., Gingras, A.-C., Herst, P., Paquet, E., Pandita, R.K., Roques, C., Lambert, J.-P., Avvakumov, N., Fradet-Turcotte, A., Jacquet, K., Molecular Cell, 2016, 10.1016/j.molcel.2016.03.031
  • Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme, Holmes, M.C., Gregory, P.D., Babiarz, J.E., Yan, J.J., Hua, K.L., Miller, J.C., Li, C.J., Wang, N.S., Doyon, Y., Friedman, G., Wang, J., Genome Research, 2012, 10.1101/gr.122879.111
  • Accessory-cell-free differentiation of hematopoietic stem and progenitor cells into mature red blood cells, Josée Laganière, Yannick Doyon, Nellie Dumont, Yelena Boccacci, Cytotherapy, 2023, 10.1016/j.jcyt.2023.07.007
  • Marker-free coselection for successive rounds of prime editing in human cells, Yannick Doyon, Daniel Agudelo, Eva Bouchard, Andréanne Loiselle, Alexis Duringer, Claudia Goupil, Jean-Philippe Fiset, Diana Mayorga, Sébastien Levesque, 2021, 10.1101/2021.11.02.464583
  • Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures, Holmes, M.C., Gregory, P.D., Urnov, F.D., Miller, J.C., Xia, D.F., Wang, J., Greenberg, S.G., Mendel, M.C., Vo, T.D., Doyon, Y., Nature Methods, 2011, 10.1038/nmeth.1539
  • A Scalable Genome-Editing-Based Approach for Mapping Multiprotein Complexes in Human Cells, Doyon, Y., Côté, J., Herst, P., Roques, C., Huard, C.C., Jacquet, K., Loehr, J., Dalvai, M., Cell Reports, 2015, 10.1016/j.celrep.2015.09.009
  • Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells, Drubin, D.G., Urnov, F.D., Gregory, P.D., Rebar, E.J., Zhang, L., Paschon, D.E., Miller, J.C., Doyon, Y., Vo, T.D., Lee, A.H., Santiago, Y., Cherone, J.M., Cheng, A.T., Cheng, J., Zeitler, B., Doyon, J.B., Nature Cell Biology, 2011, 10.1038/ncb2175
  • Precise genome modification in the crop species Zea mays using zinc-finger nucleases, Urnov, F.D., Gregory, P.D., Rebar, E.J., Zhang, L., Hinkley, S.J., Butler, H.J., Greenwalt, S.A., Blakeslee, B., Simpson, M.A., McCaskill, D., Zhifang, G., Katibah, G.E., Wu, Y.-Y., Rock, J.M., Choi, V.M., Meng, X., Gopalan, S., Arnold, N.L., Mitchell, J.C., Worden, S.E., Moehle, E.A., Dekelver, R.C., Miller, J.C., Doyon, Y., Shukla, V.K., Nature, 2009, 10.1038/nature07992
  • In vivo dissection of the mouse tyrosine catabolic pathway with CRISPR-Cas9 identifies modifier genes affecting hereditary tyrosinemia type 1., Yannick Doyon, Paganelli M, Paula Waters, Mac-Way F, Dal Soglio D, Ung RV, Cyr D, Antérieux P, Goupil C, Carter S, Jean-François Rivest, Genetics, 2024, 10.1093/genetics/iyae139
  • Transient cold shock enhances zinc-finger nuclease-mediated gene disruption, Holmes, M.C., Gregory, P.D., Vo, T.D., Xia, D.F., Choi, V.M., Doyon, Y., Nature Methods, 2010, 10.1038/nmeth.1456
  • Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation, Côté, J., Kutateladze, T.G., Yang, X.-J., Richard, D.E., Robitaille, G.A., Cayrou, C., Doyon, Y., Landry, A.-J., Glass, K.C., Paquet, E., Saksouk, N., Lalonde, M.-E., Avvakumov, N., Molecular and Cellular Biology, 2012, 10.1128/MCB.06455-11
  • Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases, Zeitler, B., Harland, R.M., Urnov, F.D., Gregory, P.D., Rebar, E.J., Zhang, L., Miller, J.C., Paschon, D.E., Guschin, D.Y., Ngo, C., Lee, A.H., Faraji, F.M., Ankoudinova, I., Doyon, Y., Cherone, J.M., Young, J.J., Proceedings of the National Academy of Sciences of the United States of America, 2011, 10.1073/pnas.1102030108
  • Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex, Côté, J., Lane, W.S., Allard, S., Utley, R.T., Doyon, Y., Nourani, A., Molecular and Cellular Biology, 2001, 10.1128/MCB.21.22.7629-7640.2001
  • ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation, Côté, J., Yang, X.-J., Tan, S., Lane, W.S., Selleck, W., Côté, V., Landry, A.-J., Ullah, M., Cayrou, C., Doyon, Y., Molecular Cell, 2006, 10.1016/j.molcel.2005.12.007
  • In vivo genome editing restores haemostasis in a mouse model of haemophilia, High, K.A., Holmes, M.C., Gregory, P.D., Bushman, F.D., Rebar, E.J., Paschon, D.E., Zhou, S., Khazi, F.R., Finn, J.D., Murphy, S.L., Ivanciu, L., Sharma, R., Anguela, X.M., Malani, N., Bhagwat, A.S., Wong, S.Y., Li, T., Doyon, Y., Haurigot, V., Li, H., Nature, 2011, 10.1038/nature10177
  • IL-1α gene deletion protects oligodendrocytes after spinal cord injury through upregulation of the survival factor Tox3, Lacroix, S., Doyon, Y., Tremblay, M.-È., Takashima, A., Champagne, M., Vallières, N., Lessard, M., Landete, V.B., Bastien, D., Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.0498-15.2015
  • HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail, Côté, J., Kutateladze, T.G., Gozani, O., Yang, X.-J., Côté, V., Landry, A.-J., Ullah, M., Paquet, E., Cayrou, C., Doyon, Y., Hung, T., Champagne, K.S., Avvakumov, N., Saksouk, N., Molecular Cell, 2009, 10.1016/j.molcel.2009.01.007
  • Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins, Sylvain Moineau, Christian Cambillau, Yannick Doyon, Philippe Horvath, Christophe Fremaux, Dennis A. Romero, Jeremy Loehr, Beatrice Amigues, Adeline Goulet, Daniel Agudelo, Geneviève M. Rousseau, Alexander P. Hynes, Nature Communications, 2018, 10.1038/s41467-018-05092-w
  • Preparation and Analysis of Native Chromatin-Modifying Complexes, Côté, J., Doyon, Y., Methods in Enzymology, 2016, 10.1016/bs.mie.2016.01.017
  • Marker-free coselection for CRISPR-driven genome editing in human cells, Doyon, Y., Laganière, J., Dellaire, G., Salsman, J., Drouin, M., Synodinou, D., Loehr, J., Carter, S., Huard, C.C., Bozoyan, L., Duringer, A., Agudelo, D., Nature Methods, 2017, 10.1038/nmeth.4265
  • Eaf1 Is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants, Côté, J., Allard, S., Cronier, D., Utley, R.T., Doyon, Y., Nourani, A., Altaf, M., Galarneau, L., Auger, A., Molecular and Cellular Biology, 2008, 10.1128/MCB.01755-07
  • Gene therapy in tyrosinemia: Potential and pitfalls, Doyon, Y., Carter, S., Advances in Experimental Medicine and Biology, 2017, 10.1007/978-3-319-55780-9_21
  • Identification and Analysis of Native HAT Complexes, Grant, P.A., Côté, J., Doyon, Y., McMahon, S.J., Methods in Enzymology, 2004, 10.1016/S0076-6879(03)77008-6
  • The highly conserved and multifunctional NuA4 HAT complex, Côté, J., Doyon, Y., Current Opinion in Genetics and Development, 2004, 10.1016/j.gde.2004.02.009
  • Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases, Amacher, S.L., Urnov, F.D., Gregory, P.D., Rebar, E.J., Zhang, L., Hocking, T.D., Amora, R., Katibah, G.E., Ngo, C., Faraji, F., Miller, J.C., McCammon, J.M., Doyon, Y., Nature Biotechnology, 2008, 10.1038/nbt1409
  • Rewired Cas9s with Minimal Sequence Constraints., , Trends in pharmacological sciences, 2020, 10.1016/j.tips.2020.04.009
  • Dairy phages escape CRISPR defence of Streptococcus thermophilus via the anti-CRISPR AcrIIA3., Moineau S, Doyon Y, Goulet A, Fiset JP, Levesque S, Somerville V, Rousseau GM, Adeline Pastuszka, International journal of food microbiology, 2023, 10.1016/j.ijfoodmicro.2023.110414
  • In vivo genome editing of the albumin locus as a platform for protein replacement therapy, High, K.A., Rebar, E.J., Holmes, M.C., Rieders, J., Gregory, P.D., Zhou, S., Shivak, D., Davidson, R.J., Miller, J.C., Paschon, D.E., Sproul, S., DeKelver, R.C., Wechsler, T., Doyon, Y., Anguela, X.M., Sharma, R., Blood, 2015, 10.1182/blood-2014-12-615492
  • In vivodissection of the mouse tyrosine catabolic pathway with CRISPR-Cas9 identifies modifier genes affecting hereditary tyrosinemia type 1, Yannick Doyon, Massimiliano Paganelli, Paula J. Waters, Fabrice Mac-Way, Dorothée Dal Soglio, Roth-Visal Ung, Denis Cyr, Claudia Goupil, Sophie Carter, Jean-François Rivest, 2023, 10.1101/2023.09.29.559947
  • Marker-free co-selection for successive rounds of prime editing in human cells, Yannick Doyon, Daniel Agudelo, Eva Bouchard, Andréanne Loiselle, Alexis Duringer, Claudia Goupil, Jean-Philippe Fiset, Diana Mayorga, Sébastien Levesque, Nature Communications, 2022, 10.1038/s41467-022-33669-z
  • Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6., , Molecular cell, 2019, 10.1016/j.molcel.2019.09.012
  • Cancer translocations in human cells induced by zinc finger and TALE nucleases, Brunet, E., Jasin, M., Giovannangeli, C., Concordet, J.-P., Doyon, Y., Holmes, M.C., Zhang, L., Katibah, G.E., René, O., Perrouault, L., Tomishima, M., Guittat, L., De Cian, A., Ghezraoui, H., Piganeau, M., Genome Research, 2013, 10.1101/gr.147314.112
  • Accessory-cell-free differentiation of hematopoietic stem and progenitor cells into mature red blood cells, Josée Laganière, Yannick Doyon, Nellie Dumont, Yelena Boccacci, 2022, 10.1101/2022.09.14.507311
  • Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans, Côté, J., Tan, S., Lane, W.S., Selleck, W., Doyon, Y., Molecular and Cellular Biology, 2004, 10.1128/MCB.24.5.1884-1896.2004
  • Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9., , Genome research, 2020, 10.1101/gr.255414.119
  • Robust ZFN-mediated genome editing in adult hemophilic mice, High, K.A., Holmes, M.C., Gregory, P.D., Zhou, S., Davidson, R.J., Wong, S.Y., Rohde, M.E., Haurigot, V., Li, H., Doyon, Y., Miller, J.C., Sharma, R., Anguela, X.M., Blood, 2013, 10.1182/blood-2013-04-497354
  • Targeted transgene integration in plant cells using designed zinc finger nucleases, Petolino, J.F., Urnov, F.D., Gregory, P.D., Rubin-Wilson, B., Collingwood, T.N., Rebar, E.J., Holmes, M.C., Zhang, L., Baker, L., Faraji, F., Worden, A., Blue, R., Schulenberg, L., Garrison, R., Lee, Y.-L., DeKelver, R.C., Moehle, E.A., Rock, J.M., Miller, J.C., Ainley, W.M., Doyon, Y., Cai, C.Q., Plant Molecular Biology, 2009, 10.1007/s11103-008-9449-7
  • Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci., Jacques Cote, Doyon Y, Taipale M, Droit A, Gingras AC, Benoit Coulombe, Rouzbahman M, Bernardini MQ, Loehr J, Thonta Setty S, Lachance C, Paquet E, Lara Herrmann, Rousseau J, Lambert JP, Amel Mameri, Jacquet K, Joly-Beauparlant C, Alerasool N, Lalonde ME, Avvakumov N, Sudarshan D, Genes & development, 2022, 10.1101/gad.348982.121

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Pénélope Antérieux - Doctorat - En cours
  • Diana Carolina Mayorga Gonzalez - Doctorat - En cours
  • Simon-Alexandre Lafontaine Gosselin - Maîtrise avec mémoire - En cours
  • Jérémy Loehr - Maîtrise avec mémoire - 2017/05
  • Alexandre Raymond Fleury - Maîtrise avec mémoire - 2017/09
  • Catherine Giroux - Maîtrise avec mémoire - 2018/01
  • Yelena Boccacci - Maîtrise avec mémoire - 2020/05
  • Daniel Agudelo - Doctorat - 2022/01
  • Sebastien Levesque - Doctorat - 2022/09
  • Minja Velimirovic - Doctorat - 2024/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Médecine moléculaire

En savoir plus sur les programmes

Disponibilité d'encadrement d'étudiant(e)s

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.