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Yves De Koninck

Professeur titulaire

Directeur(trice), Centre de recherche CERVO

Directeur(trice), Centre de recherche CERVO

yves.dekoninck@neuro.ulaval.ca
Centre de recherche CERVO
Centre d'optique, photonique et laser
Centre thématique de recherche en neurosciences
Centre de recherche CERVO
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Contribution à la recherche

Projets de recherche

  • Centre d'optique, photonique et lasers - École polytechnique de Montréal, Université du Québec à Trois-Rivières, École de technologie supérieure, Université de Sherbrooke, Université Concordia, Université Laval - Fonds internes, Institut national de recherche scientifique (INRS), Fonds de recherche du Québec - Nature et technologies, Université McGill - Regroupements stratégiques NT, co-chercheur - 2024-04-01 au 2030-03-31
  • Chaire de recherche du Canada en douleur chronique et troubles cérébraux associés - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2023-01-01 au 2029-12-31
  • Laboratoire international associé (LIA) sur les neurotechnologies pour décoder la douleur chronique et les troubles mentaux associés (DecodePain) - Université Laval - Fonds internes - Laboratoire international associé (LIA), chercheur principal - 2024-05-01 au 2029-04-30
  • Union Neurosciences et Intelligence Artificielle - Québec (UNIQUE) - Université Laval - Fonds internes, Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2022-04-01 au 2028-03-31
  • Programme VISION - Fonds de recherche du Québec - Santé - Tremplin, co-chercheur - 2022-11-15 au 2026-03-31
  • Unraveling sensory coding dysfunctions that underlie chronic pain - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2018-07-01 au 2025-06-30
  • Appui à l'École d'été "Neural circuits of pain: from physiology to pathology" - Université Laval - Fonds internes - Programme d'appui aux initiatives internationales, chercheur principal - 2024-04-29 au 2025-04-30
  • Engineering a genetically-encoded D-serine biosensor for studying its role in neurotransmission - Fonds France Canada pour la recherche - Nouvelles collaborations de recherche, chercheur principal - 2023-05-01 au 2025-04-30
  • Tools to decipher neuronal signalling and computation - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2020-04-01 au 2025-03-31
  • The Canadian Brain Research Strategy (International Brain Initiative Canadian Secretariat) - Instituts de recherche en santé du Canada - Subventions Catalyseur de réseaux, chercheur principal - 2020-04-01 au 2025-03-31
  • Pôle de recherche et d'innovation pour accélérer la transition vers des systèmes alimentaires durables et résilients - Fonds de recherche du Québec - Nature et technologies - APPEL à Pôle de recherche et d’innovation du FRQNT – Secteur Bioalimentaire, co-chercheur - 2022-04-01 au 2025-03-31
  • A prospective translational model of the therapeutic potential of cannabidiol in reducing acute pain symptoms and opioid usage following traumatic injury - Instituts de recherche en santé du Canada - Subvention d'équipe:Recherche sur le cannabis dans des domaines prioritaires, Université de Montréal, co-chercheur - 2020-01-01 au 2024-12-31
  • Décoder la représentation de la température par les neurones de projection de la moelle épinière à l’aide de l’imagerie cellulaire fonctionnelle in vivo - MITACS Inc. - Bourse de recherche Mitacs Globalink, chercheur principal - 2024-05-27 au 2024-10-27
  • Centre d'optique photonique et laser (COPL) - Université de Sherbrooke, École polytechnique de Montréal, Université McGill, Université Concordia, Fonds de recherche du Québec - Nature et technologies, École de technologie supérieure, Université Laval - Fonds internes - Regroupements stratégiques NT, co-chercheur - 2017-04-01 au 2024-03-31
  • Canadian Optogenetics and Vectorology Foundry - Université d'Ottawa, The Governos of the University of Calgary, Brain Canada Foundation, The Royal Institution for the advancement of learning, Djavad Mowafaghian Centre for Brain Health, Fondation CERVO, chercheur principal - 2020-10-01 au 2024-03-31
  • Muscarinic receptor antagonisrn as a novel mechanism for sensory nerve repair - Instituts de recherche en santé du Canada - Subvention Projet, University of Manitoba, co-chercheur - 2019-04-01 au 2024-03-31
  • Smart, adaptative, and autonomous sensing - Université Laval - Fonds internes, Sentinelle Nord (usage exclusif VRRCI), Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Programme de formation orientée vers la nouveauté, la collaboration et l'expérience en recherche (FONCER), co-chercheur - 2017-04-01 au 2024-03-31
  • Lasers femtosecondes tout-fibre pour applications en micro-usinage et en biophotonique - TeraXion, Conseil de recherches en sciences naturelles et génie Canada - Subventions Missions d’Alliance, chercheur principal - 2022-03-31 au 2024-03-30
  • Novel technology for quality control of viral vector particles - Conseil de recherches en sciences naturelles et génie Canada - Subventions Missions d’Alliance, chercheur principal - 2022-03-01 au 2024-02-28
  • Chaire de recherche sur le cerveau et la douleur - Fondation de l'Université Laval - Chaires de recherche sans organismes subventionnaires, chercheur principal - 2013-12-10 au 2023-12-10
  • Comorbidity of cHronic Pain and mood disorders: breaking the vicious cYcle HaPpY - Centre national de la recherche scientifique (France) - Marie-Sklodowska-Curie action- Initiative Training Networks (ITN), chercheur principal - 2021-07-01 au 2023-06-30
  • Mechanisms of itch - from endosomal signalling to neural circuits - Australian Research Council, Monash University, co-chercheur - 2019-04-01 au 2023-03-31
  • Smart neuroscience platform enhancement and pilot data on using KCC2 as a new target for Alzheimer's disease - Weston Brain institute - Transformational Research, co-chercheur - 2020-01-01 au 2023-03-31
  • Dépenses pour le congrès de l'IASP - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, chercheur principal - 2022-04-01 au 2023-03-31
  • Mechanisms of itch - from endosomal signalling to neural circuits - Australian Research Council, Monash University, co-chercheur - 2018-04-01 au 2023-03-31
  • Chloride dysregulation and neuropathic pain: Linking molecular mechanisms with altered pain processing via identification of cellular and circuit level changes - Instituts de recherche en santé du Canada - Subvention Projet, University of Toronto, co-chercheur - 2017-04-01 au 2023-03-31
  • Chaire de recherche du Canada en douleur chronique et troubles cérébraux associés - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2016-01-01 au 2022-12-31
  • Modulation de l'activité des réseaux de la corne dorsale de la moelle épinière par des systèmes en boucles fermées - MITACS Inc. - Bourse de recherche Mitacs Globalink, chercheur principal - 2022-03-13 au 2022-09-12

Publications

  • Editorial: Shedding Light on the Nervous System: Progress in Neurophotonics Research, De Koninck, Y., Béïque, J.-C., Ruthazer, E.S., Frontiers in Neural Circuits, 2022, 10.3389/fncir.2022.901376
  • The effects of raising intracellular calcium on synaptic GABA(A) receptor-channels, , Neuropharmacology, 1996, 10.1016/S0028-3908(96)00063-9
  • Mechanisms of plasticity of inhibition in chronic pain conditions, De Koninck, Y., Ferrini, F., Labrakakis, C., Inhibitory Synaptic Plasticity, 2011, 10.1007/978-1-4419-6978-1_7
  • A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments, De Koninck, Yves, Bories, Cyril, Bonin, Robert P., Molecular Pain, 2014, 10.1186/1744-8069-10-26
  • Allosteric modulation of metabotropic glutamate receptors by chloride ions, Goudet, Cyril, Acher, Francine, Pin, Jean-Philippe, Doyon, Nicolas, De Koninck, Yves, Brabet, Isabelle, Bertrand, Hugues-Olivier, Dione, Ibrahima, Rovira, Xavier, Tora, Amelie S., Faseb Journal, 2015, 10.1096/fj.14-269746
  • Mild KCC2 Hypofunction Causes Inconspicuous Chloride Dysregulation that Degrades Neural Coding, De Koninck, Yves, Prescott, Steven A., Doyon, Nicolas, Frontiers in Cellular Neuroscience, 2016, 10.3389/fncel.2015.00516
  • Modulation of chloride homeostasis by microglia, De Koninck, Y., Physiology and Pathology of chloride transporters and channels in the nervous system, 2010, 10.1016/B978-0-12-374373-2.00023-6
  • Normal and abnormal coding of somatosensory stimuli causing pain, De Koninck, Yves, Ma, Qiufu, Prescott, Steven A., Nature Neuroscience, 2014, 10.1038/nn.3629
  • Reconsolidation and the regulation of plasticity: moving beyond memory, De Koninck, Yves, Bonin, Robert P., Trends in Neurosciences, 2015, 10.1016/j.tins.2015.04.007
  • Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain, Alfredo Ribeiro-da-Silva, Yves De Koninck, Arkady Khoutorsky, Johanne Ouellette, Manon St-Louis, Lucas Marques, Chengyang Wang, Haley Deamond, Samantha Locke, Noosha Yousefpour, Cell Reports, 2023, 10.1016/j.celrep.2023.112010
  • Dorsal horn neurons presynaptic to lamina I spinoparabrachial neurons revealed by transynaptic labeling, , Journal of Comparative Neurology, 2009, 10.1002/cne.22179
  • Spinal microglia are required for long-term maintenance of neuropathic pain., , Pain, 2017, 10.1097/j.pain.0000000000000982
  • Maintaining polarization in polarimetric multiphoton microscopy, Cote, Daniel C., De Koninck, Yves, Bachand, Karine, Gravel, Pierre, Sadetsky, Gregory, Daradich, Amy, Turcotte, Raphael, Belanger, Erik, Journal of Biophotonics, 2015, 10.1002/jbio.201400116
  • Reply, , Trends in Neurosciences, 1995, 10.1016/0166-2236(95)80006-N
  • Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases., Lacroix, Steve, Cote, Daniel, Prat, Alexandre, Engelhardt, Britta, De Koninck, Yves, Alvarez, Jorge I, Lecuyer, Marc-Andre, Gorina, Roser, Kebir, Hania, Chamma, Emilie, Pare, Alexandre, Levesque, Sebastien A, Aube, Benoit, Journal of immunology (Baltimore, Md. : 1950), 2014, 10.4049/jimmunol.1400401
  • For a structured response to the psychosocial consequences of the restrictive measures imposed by the global COVID-19 health pandemic: the MAVIPAN longitudinal prospective cohort study protocol, Claudia Savard, Marie-Christine Saint-Jacques, Marc-André Roy, Marie-Christine Ouellet, Chantal Merette, Matthew Menear, Lily Lessard, Maripier Isabelle, Marie-Hélène Gagné, Richard Fleet, Émilie Dionne, Nancy Côté, Delphine Collin-Vézina, Caroline Cellard, Yves De Koninck, Marc Hébert, Jean-Pierre Despres, Catherine Mercier, Francois Routhier, George Tarabulsy, Patrick Blouin, Marie Baron, Annie LeBlanc, BMJ Open, 2022, 10.1136/bmjopen-2021-048749
  • Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia, Kahle, K.T., Lifton, R.P., De Koninck, Y., Haider, S., Chahine, M., Alper, S.L., Barker, F.G., Waxman, S.G., Dib-Hajj, S., Gerrard, J.L., Günel, M., Moliterno, J., Gottschalk, C., Eskandar, E.N., Simard, J.M., Sekula, R.F., Knight, J.R., López-Giráldez, F., Castaldi, C., Mane, S., Li, X., Sierant, M.C., Liu, W., Zhou, G., Lu, Q., Li, B., Loring, E., Kundishora, A.J., Duy, P.Q., Conine, S., Furey, C.G., Kiziltug, E., Nelson-Williams, C., Dunbar, A., Choi, J., Gaillard, J., Sularz, A., Hu, J., Bachand, K., Brindle, G., Islam, B., Lorenzo, L.-É., Castonguay, A., Panchagnula, S., Sheth, A.H., Zeng, X., Allocco, A., Jin, S.C., Dong, W., iScience, 2020, 10.1016/j.isci.2020.101552
  • Transmission nerveuse de la douleur : mécanismes endogènes de contrôle au niveau spinal, , Médecine/sciences, 2012, 10.4267/10608/410
  • Sensory Afferents Use Different Coding Strategies for Heat and Cold., , Cell reports, 2018, 10.1016/j.celrep.2018.04.065
  • Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain, Fossat, P., De Koninck, Y., Landry, M., Fioramonti, X., Herry, C., Godin, A.G., De Deurwaerdere, P., Bouchatta, O., Idi, W., Isabel, D., Whitestone, S., Valerio, S., Martin, H., Bouali-Benazzouz, R., Grivet, Z., Lorenzo, L.-E., Aby, F., Science Advances, 2022, 10.1126/sciadv.abo0689
  • Optrodes for combined optogenetics and electrophysiology in live animals., De Koninck, Yves, Dufour, Suzie, Neurophotonics, 2015, 10.1117/1.NPh.2.3.031205
  • Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents., , Nature medicine, 2017, 10.1038/nm.4281
  • Lasting potentiation of inhibition is associated with an increased number of γ-aminobutyric acid type A receptors activated during miniature inhibitory postsynaptic currents, , Proceedings of the National Academy of Sciences of the United States of America, 1994, 10.1073/pnas.91.16.7698
  • Resolution and contrast enhancement in laser scanning microscopy using dark beam imaging, De Koninck, Yves, Piche, Michel, Dehez, Harold, Optics Express, 2013, 10.1364/OE.21.015912
  • Spatial Intensity Distribution Analysis Reveals Abnormal Oligomerization of Proteins in Single Cells, Wisemant, Paul W., De Koninck, Yves, Kennedy, Timothy E., Potvin-Trottier, Laurent, Rappaz, Benjamin, Godin, Antoine G., Biophysical Journal, 2015, 10.1016/j.bpj.2015.06.068
  • Dynamics of spinal microglia repopulation following an acute depletion, Zhang, Ji, De Koninck, Yves, Fu, Kai Yuan, Wu, Yi Chen, Chambon, Julien, Wang, Guan Yun Frances, Yang, Qiu Zi, Yang, Mu, Shi, Xiang Qun, Echeverry, Stefania, Yao, Yao, Scientific Reports, 2016, 10.1038/srep22839
  • Live single-cell laser tag, Santiago Costantino, Claudia L. Kleinman, Jiannis Ragoussis, Yves De Koninck, El Bachir Affar, Yu Chang Wang, Louis-Etienne Lorenzo, Karine Choquet, Javier Mazzaferri, Loïc Binan, Nature Communications, 2016, 10.1038/ncomms11636
  • Amiloride modulation of carbon dioxide hypersensitivity and thermal nociceptive hypersensitivity induced by interference with early maternal environment., , Journal of psychopharmacology (Oxford, England), 2018, 10.1177/0269881118784872
  • Altered chloride homeostasis in neurological disorders: a new target, , Current Opinion in Pharmacology, 2007, 10.1016/j.coph.2006.11.005
  • Imaging physical properties and dynamics of dendritic spines by atomic force microscopy, , Microscopy and Microanalysis, 2002
  • Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine, Cahill, Catherine M., Evans, Christopher J., De Koninck, Yves, Olmstead, Mary C., Levitt, Pat, Wu, Juli, Mehrabani, Sadaf, Xue, Lihua, Pradhan, Amynah A. A., Vayssiere, Pia, Ghogha, Atefeh, Castonguay, Annie, Taylor, Anna M. W., Neuropsychopharmacology, 2016, 10.1038/npp.2015.221
  • A Wireless Fiber Photometry System Based on a High-Precision CMOS Biosensor With Embedded Continuous-Time Modulation., , IEEE transactions on biomedical circuits and systems, 2018, 10.1109/tbcas.2018.2817200
  • Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition., , eLife, 2017, 10.7554/eLife.28270
  • Aging causes a preferential loss of cholinergic innervation of characterized neocortical pyramidal neurons, Cuello, AC, Ribeiro-da-Silva, A, De Koninck, Y, Wong, TP, Casu, MA, Cerebral Cortex, 2002, 10.1093/CERCOR/12.3.329
  • Cholinergic nerve terminals establish classical synapses in the rat cerebral cortex: Synaptic pattern and age-related atrophy, , Neuroscience, 2001, 10.1016/S0306-4522(01)00172-5
  • A spinal analog of memory reconsolidation enables reversal of hyperalgesia, De Koninck, Yves, Bonin, Robert P., Nature Neuroscience, 2014, 10.1038/nn.3758
  • Chemokines and pain mechanisms, , Brain Research Reviews, 2009, 10.1016/j.brainresrev.2008.12.002
  • Pharmacological enhancement of delta-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice, Orser, Beverley A., De Koninck, Yves, Whissell, Paul D., Eng, David G., Labrakakis, Charalampos, Bonin, Robert P., Pain, 2011, 10.1016/j.pain.2011.02.011
  • Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite the Presence of GABA(A) Receptors, De Koninck, Yves, Ribeiro-da-Silva, Alfredo, Wiseman, Paul W., Carbonetto, Salvatore, St-Louis, Manon, Wang, Feng, Godin, Antoine G., Lorenzo, Louis-Etienne, Journal of Neuroscience, 2014, 10.1523/JNEUROSCI.0159-14.2014
  • Microglia Disrupt Mesolimbic Reward Circuitry in Chronic Pain, Cahill, Catherine M., Evans, Christopher J., De Koninck, Yves, Olmstead, Mary C., Xue, Lihua, Cook, Christopher, Ghogha, Atefeh, Murphy, Niall P., Taylor, Alison J., Castonguay, Annie, Taylor, Anna M. W., Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.4036-14.2015
  • Integration time in a subset of spinal lamina I neurons is lengthened by sodium and calcium currents acting synergistically to prolong subthreshold depolarization, , Journal of Neuroscience, 2005, 10.1523/JNEUROSCI.0356-05.2005
  • Pain transmission: Endogenous spinal control mechanisms,Transmission nerveuse de la douleur: Mechanismes endogenes de controle au niveau spinal, De Koninck, Y., Medecine/Sciences, 1997
  • Reduction of anion reversal potential subverts the inhibitory control of firing rate in spinal lamina I neurons: Towards a biophysical basis for neuropathic pain, , Molecular Pain, 2006, 10.1186/1744-8069-2-32
  • Le Rôle des purines dans la modulation de la douleur au niveau spinal par la stimulation d'afférences non nociceptives, Henry, J.L., De Koninck, Y., Salter, M.W., Douleur et Analgésie, 1990, 10.1007/BF03009146
  • The heterogeneity in GABAA receptor-mediated IPSC kinetics reflects heterogeneity of subunit composition among inhibitory and excitatory interneurons in spinal lamina II, , Frontiers in Cellular Neuroscience, 2014, 10.3389/FNCEL.2014.00424
  • Spatial intensity distribution Analysis (SpIDA): A fluorescence microscopy based method to measure receptor oligomerization in cells, Beaulieu, J., De Koninck, Y., Ribeiro-da-Silva, A., Costantino, S., Swift, J.L., Godin, A.G., Wiseman, P.W., Microscopy and Microanalysis, 2012, 10.1017/S1431927612002498
  • PAK Inactivation Impairs Social Recognition in 3xTg-AD Mice without Increasing Brain Deposition of Tau and A beta, Calon, Frederic, Tonegawa, Susumu, De Koninck, Yves, Guitton, Matthieu J., Bennett, David A., Tremblay, Cyntia, Dal-Pan, Alexandre, Arsenault, Dany, Journal of Neuroscience, 2013, 10.1523/JNEUROSCI.1501-13.2013
  • Live animal myelin histomorphometry of the spinal cord with video-rate multimodal nonlinear microendoscopy, Cote, Daniel, De Koninck, Yves, Vallee, Real, Laffray, Sophie, Crepeau, Joel, Belanger, Erik, Journal of Biomedical Optics, 2012, 10.1117/1.JBO.17.2.021107
  • Sex-Dependent Alterations in Social Behaviour and Cortical Synaptic Activity Coincide at Different Ages in a Model of Alzheimer's Disease, , PLoS ONE, 2012, 10.1371/journal.pone.0046111
  • Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury, , Journal of Neurochemistry, 2006, 10.1111/j.1471-4159.2006.03746.x
  • Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain, Michael E Hildebrand, Eve C Tsai, Yves De Koninck, Paul J Lombroso, Jeffrey A Landrigan, Geneviève Glavina, Chaya M Kandegedara, Antoine G Godin, Jian Xu, Louis-Étienne Lorenzo, Annemarie Dedek, Brain, 2022, 10.1093/brain/awab408
  • Postnatal changes in the rexed lamination and markers of nociceptive afferents in the superficial dorsal horn of the rat, , Journal of Comparative Neurology, 2008, 10.1002/cne.21691
  • Differential Balance of Prefrontal Synaptic Activity in Successful versus Unsuccessful Cognitive Aging, De Koninck, Yves, Guitton, Matthieu J., Husson, Zoe, Bories, Cyril, Journal of Neuroscience, 2013, 10.1523/jneurosci.3258-12.2013
  • Differential Expression of Acid - Sensing Ion Channels in Mouse Primary Afferents in Naive and Injured Conditions, Wang, Feng, De Koninck, Yves, Godin, Antoine G., Labrecque, Simon, Papalampropoulou-Tsiridou, Melina, Frontiers in Cellular Neuroscience, 2020, 10.3389/FNCEL.2020.00103
  • Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization, De Koninck, Yves, Merighi, Adalberto, Doyon, Nicolas, Salio, Chiara, Wang, Feng, Castonguay, Annie, Cottet, Martin, Plasencia-Fernandez, Isabel, Godin, Antoine G., Lorenzo, Louis-Etienne, Ferland, Samuel, Perez-Sanchez, Jimena, Ferrini, Francesco, Nature Communications, 2020, 10.1038/S41467-020-17824-Y
  • Biophysical basis for three distinct dynamical mechanisms of action potential initiation, , PLoS Computational Biology, 2008, 10.1371/journal.pcbi.1000198
  • Morphological and Neurochemical Organization of the Spinal Dorsal Horn, De Koninck, Y., Ribeiro-da-Silva, A., The Senses: A Comprehensive Reference, 2008, 10.1016/B978-012370880-9.00163-8
  • Local assessment of myelin health in a multiple sclerosis mouse model using a 2D Fourier transform approach, Cote, Daniel, De Koninck, Yves, Lacroix, Steve, Belisle, Jonathan, Chamma, Emilie, Aube, Benoit, Laffray, Sophie, Belanger, Erik, Begin, Steve, Biomedical Optics Express, 2013, 10.1364/BOE.4.002003
  • Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases, Lacroix, Steve, Sharif-Naeini, Reza, Boilard, Eric, Scherrer, Gregory, Cicchetti, Francesca, Droit, Arnaud, De Koninck, Yves, Joly-Beauparlant, Charles, Bories, Cyril, Wang, Feng, Pellerin, Eve, Turmel, Roxanne, Bretheau, Floriane, Sotoudeh, Chaudy, Tessandier, Nicolas, Christin, Marine, Mailhot, Benoit, Journal of Experimental Medicine, 2020, 10.1084/JEM.20191430
  • Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells, Ruthazer, E.S., Wiseman, P.W., Marsh-Armstrong, N., De Koninck, Y., Castonguay, A., Spratt, P., Sild, M., Schohl, A., Desjardins, J.-F., Gobert, D., Tsui, J., Miraucourt, L.S., eLife, 2016, 10.7554/eLife.15932.001
  • Treating pathological pain: is KCC2 the key to the gate?, De Koninck, Yves, Gagnon, Martin, Ferrini, Francesco, Doyon, Nicolas, Expert Review of Neurotherapeutics, 2013, 10.1586/ERN.13.40
  • Quantitative myelin imaging with coherent anti-Stokes Raman scattering microscopy: Alleviating the excitation polarization dependence with circularly polarized laser beams, , Optics Express, 2009, 10.1364/OE.17.018419
  • A Wireless Electro-Optic Headstage With a 0.13-mu m CMOS Custom Integrated DWT Neural Signal Decoder for Closed-Loop Optogenetics, Gosselin, Benoit, De Koninck, Yves, Ethier, Christian, Keramidis, Iason, Gagnon-Turcotte, Gabriel, IEEE Transactions on Biomedical Circuits and Systems, 2019, 10.1109/TBCAS.2019.2930498
  • Remote Optogenetic Activation and Sensitization of Pain Pathways in Freely Moving Mice, Seguela, Philippe, Mogil, Jeffrey S., Ribeiro-da-Silva, Alfredo, De Koninck, Yves, Wood, John N., Ase, Ariel R., Bonin, Robert P., Wieskopf, Jeffrey S., Longo, Geraldine, Tuttle, Alexander H., Daou, Ihab, Journal of Neuroscience, 2013, 10.1523/JNEUROSCI.2424-13.2013
  • A Wireless Headstage for Combined Optogenetics and Multichannel Electrophysiological Recording., , IEEE transactions on biomedical circuits and systems, 2016, 10.1109/tbcas.2016.2547864
  • Quantitative myelin imaging with coherent anti-Stokes Raman scattering microscopy: alleviating the excitation polarization dependence with circularly polarized laser beams, COTE, D, VALLEE, R, DE KONINCK, Y, LAFFRAY, S, BEGIN, S, BELANGER, E, OPTICS EXPRESS, 2009
  • Peripheral vibration causes an adenosine-mediated postsynaptic inhibitory potential in dorsal horn neurons of the cat spinal cord, , Neuroscience, 1992, 10.1016/0306-4522(92)90435-5
  • A 0.13-mu m CMOS SoC for Simultaneous Multichannel Optogenetics and Neural Recording, Gosselin, Benoit, De Koninck, Yves, Ethier, Christian, Khiarak, Mehdi Noormohammadi, Gagnon-Turcotte, Gabriel, IEEE Journal of Solid-State Circuits, 2018, 10.1109/JSSC.2018.2865474
  • Distribution of acid-sensing ion channel subunits in human sensory neurons contrasts with that in rodents, Yves De Koninck, Theodore J Price, Antoine G Godin, Feng Wang, Stephanie Shiers, Melina Papalampropoulou-Tsiridou, Brain Communications, 2022, 10.1093/braincomms/fcac256
  • An E3-ligase-based method for ablating inhibitory synapses, Don B Arnold, Bernardo L Sabatini, Paul De Koninck, Yves De Koninck, Scott E Fraser, Le A Trinh, Richard W Roberts, Jason A Junge, William P Dempsey, Jimena Perez-Sanchez, Christoph Straub, Garrett G Gross, Nature Methods, 2016, 10.1038/nmeth.3894
  • Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia, , Current Topics in Medicinal Chemistry, 2005, 10.2174/1568026054367629
  • Chloride extrusion enhancers as novel therapeutics for neurological diseases, De Koninck, Yves, Coull, Jeffrey A. M., Attardo, Giorgio, Isenring, Paul, Kianicka, Irenej, Tardif, Christian, Jacob-Wagner, Marieve, Bachand, Karine, Valade, Isabelle, Dumas, Lionel, Wang, Bin, Boudreau, Dominic, Perez-Sanchez, Jimena, Bonin, Robert P., Tripathy, Sasmita, Castonguay, Annie, Lavertu, Guillaume, Bergeron, Marc J., Gagnon, Martin, Nature Medicine, 2013, 10.1038/nm.3356
  • NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons of the primate spinal cord, De Koninck, Y, Ribeiro-da-Silva, A, Shigemoto, R, Craig, AD, Zhang, ET, Yu, XH, The Journal of Neuroscience, 1999, 10.1523/JNEUROSCI.19-09-03545.1999
  • Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl- homeostasis, De Koninck, Yves, Salter, Michael W., Cahill, Catherine M., Beaulieu, Jean-Martin, Vandal, Karen, Beggs, Simon, Mohr, Daniela, Godin, Antoine G., Zhang, Wenbo, Doyon, Nicolas, Castonguay, Annie, Lorenzo, Louis-Etienne, Del'Guidice, Thomas, Laffray, Sophie, Mattioli, Theresa-Alexandra M., Trang, Tuan, Ferrini, Francesco, Nature Neuroscience, 2013, 10.1038/nn.3295
  • Endogenous GABA activates small-conductance K+ channels underlying slow IPSCs in rat hippocampal neurons, Mody, I., De Koninck, Y., Journal of Neurophysiology, 1997, 10.1152/jn.1997.77.4.2202
  • Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain, , Journal of Neuroscience, 2007, 10.1523/JNEUROSCI.3016-07.2007
  • Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition, Woodin, M.A., Airaksinen, M., Anggono, V., De Koninck, Y., Emili, A., Pawson, T., Bagshaw, R.D., Kwan, J., Uvarov, P., Chevrier, J., Dargaei, Z., Khademullah, C.S., Mahadevan, V., eLife, 2017, 10.7554/eLife.28270.001
  • Differential progression of Dark Neuron and Fluoro-Jade labelling in the rat hippocampus following pilocarpine-induced status epilepticus, , Neuroscience, 2000, 10.1016/S0306-4522(00)00026-9
  • Quantification of receptor tyrosine kinase activation and transactivation by G-protein-coupled receptors using spatial intensity distribution analysis (SpIDA)., Wiseman, Paul W, Swift, Jody L, Godin, Antoine G, De Koninck, Yves, Beaulieu, Jean-Martin, Barbeau, Annie, Methods in enzymology, 2013, 10.1016/B978-0-12-407865-9.00007-8
  • Organization of substance P primary sensory neurons: ultrastructural and physiological correlates, Henry, J.L., De Koninck, Y., Ma, W., Ribeiro-da-Silva, A., Cuello, A.C., Regulatory Peptides, 1993, 10.1016/0167-0115(93)90026-5
  • Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells, Ruthazer, E. S., Wiseman, P. W., Marsh-Armstrong, N., De Koninck, Y., Castonguay, A., Spratt, P., Sild, M., Schohl, A., Desjardins, J. F., Gobert, D., Tsui, J., Miraucourt, L. S., eLife, 2016, 10.7554/ELIFE.15932
  • Plasmon-induced immobilization of xanthene chemosensors toward repurposing as SERS nanotags, Yves De Koninck, Younes Messaddeq, Augusto Batagin-Neto, Paulo N. Lisboa-Filho, Mourad Roudjane, Ali Riaz, Orisson Gomes, Sanggon Kim, Surfaces and Interfaces, 2024, 10.1016/j.surfin.2023.103647
  • Microglia Control Neuronal Network Excitability via BDNF Signalling, De Koninck, Yves, Ferrini, Francesco, Neural Plasticity, 2013, 10.1155/2013/429815
  • The International Brain Initiative: enabling collaborative science, Bjaalie, Jan G., Richards, Linda, Ngai, John, De Koninck, Yves, Rah, Jong-Cheol, Poo, Mu-ming, Okabe, Shigeo, Amunts, Katrin, Karapiperis, Theodoros, Moser, Edvard I., Toia, Patrizia, Quaglio, Gianluca, The Lancet Neurology, 2021, 10.1016/S1474-4422(21)00389-6
  • Anisotropic light scattering from myelinated axons in the spinal cord, Côté, D.C., Parent, M., De Koninck, Y., Bonin, R.P., Perez-Sanchez, J., Goetz, L., Deschenes, J.M., Bahdine, M., Gasecka, A., Depaoli, D., Neurophotonics, 2020, 10.1117/1.NPh.7.1.015011
  • Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat, Yves De Koninck, Steven A. Prescott, The Journal of Physiology, 2002, 10.1013/JPHYSIOL.2001.013437
  • Physiological roles for adenosine and ATP in synaptic transmission in the spinal dorsal horn, , Progress in Neurobiology, 1993, 10.1016/0301-0082(93)90006-E
  • A Neuroethics Backbone for the Evolving Canadian Brain Research Strategy., , Neuron, 2019, 10.1016/j.neuron.2018.12.021
  • Gating pain; from normal to pathological sensory coding, De Koninck, Yves, Canadian Journal of Pain, 2017, 10.1080/24740527.2017.1329295
  • mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation, Khoutorsky, A., Binshtok, A.M., Ribeiro-Da-Silva, A., De Koninck, Y., Seguela, P., Mogil, J.S., Prager-Khoutorsky, M., Claudio Cuello, A., Latif, M., Lister, K.C., Hooshmandi, M., Yousefpour, N., Tansley, S., Cai, W., Lev, S., Perez, C.T., Wang, F., Barkai, O., Wong, C., Journal of Clinical Investigation, 2022, 10.1172/JCI152635
  • Bombesin, neuromedin B and neuromedin C selectively depress superficial dorsal horn neurones in the cat spinal cord, , Brain Research, 1989, 10.1016/0006-8993(89)90404-6
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  • Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing., , Brain : a journal of neurology, 2019, 10.1093/brain/awz105
  • Enhancing K-Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model, De Koninck, Yves, Cote, Sylvain L., Lavertu, Guillaume, Brain, 2014, 10.1093/brain/awt334
  • Engagement of the GABA to KCC2 Signaling Pathway Contributes to the Analgesic Effects of A(3)AR Agonists in Neuropathic Pain, Salvemini, Daniela, Jacobson, Kenneth A., Tosh, Dilip K., De Konnick, Yves, Vanderah, Todd W., Egan, Terrance M., Doyle, Timothy, Symons-Liguori, Ashley M., Chen, Zhoumou, Little, Joshua W., Cottet, Martin, Castonguay, Annie, Ford, Amanda, Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.4495-14.2015
  • Enhancing KCC2 function counteracts morphine-induced hyperalgesia, Yves De Koninck, Miorie Le Quang, Antoine G. Godin, Louis-Etienne Lorenzo, Francesco Ferrini, Scientific Reports, 2017, 10.1038/s41598-017-04209-3
  • International Brain Initiative: An Innovative Framework for Coordinated Global Brain Research Efforts, Yuste, Rafael, Wilson, Gary, White, Samantha, Welchman, Andrew E., Valdes-Sosa, Pedro A., Thiels, Edda, Tanaka, Keiji, Scobie, Kimberly N., Sajda, Paul, Reindorp, Jason, Rommelfanger, Karen S., Pouget, Alexandre, Ohtsuka, Toshihisa, Okano, Hideyuki, McMahon, Agnes, Magistretti, Pierre, Li, Yan, Lanyon, Linda, Hausser, Michael, Hale, Melina, Ebell, Christoph J., Chakli, Khaled, Bernard, Amy, Asakawa, Tasia, Amunts, Katrin, Albin, Stephanie, Zheng, Jialin, Zhang, Xu, Suh, Pann-Ghill, Richards, Linda J., Pei, Gang, Okabe, Shigeo, Montojo, Caroline, Jeong, Sung-Jin, Illes, Judy, Egan, Gary, De Koninck, Yves, Deshler, James O., Bjaalie, Jan G., Adams, Amy, Neuron, 2020, 10.1016/J.NEURON.2020.01.002
  • Epidural optogenetics for controlled analgesia, De Koninck, Yves, Cote, Daniel C., Boulanger, Marie-Eve, Gasecka, Alicja, Desrochers-Couture, Mireille, Wang, Feng, Bonin, Robert P., Molecular Pain, 2016
  • Substance P and enkephalin immunoreactivities in axonal boutons presynaptic to physiologically identified dorsal horn neurons. An ultrastructural multiple-labelling study in the cat, , Neuroscience, 1997, 10.1016/S0306-4522(96)00510-6
  • A Wireless Electro-Optic Platform for Multimodal Electrophysiology and Optogenetics in Freely Moving Rodents, Gosselin, B., Ethier, C., De Koninck, Y., Timofeev, I., Keramidis, I., Gagnon, L.L., Gagnon-Turcotte, G., Bilodeau, G., Frontiers in Neuroscience, 2021, 10.3389/fnins.2021.718478
  • Spatial and temporal pattern of changes in the number of GAD65-immunoreactive inhibitory terminals in the rat superficial dorsal horn following peripheral nerve injury, Ribeiro-da-Silva, Alfredo, De Koninck, Yves, St Louis, Manon, Bailey, Andrea L., Magnussen, Claire, Lorenzo, Louis-Etienne, Molecular Pain, 2014, 10.1186/1744-8069-10-57
  • Extended depth of field microscopy for rapid volumetric two-photon imaging, Theriault, Gabrielle, McCarthy, Nathalie, De Koninck, Yves, Optics Express, 2013, 10.1364/oe.21.010095
  • Enhanced resolution in two-photon imaging using a TM01 laser beam at a dielectric interface, DE KONINCK, Y, PICHE, M, DEHEZ, H, OPTICS LETTERS, 2009
  • Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats, , Journal of Neuroscience, 1993
  • Imbalance towards inhibition as a substrate of aging-associated cognitive impairment, , Neuroscience Letters, 2006, 10.1016/j.neulet.2005.11.055
  • Extended two-photon microscopy in live samples with Bessel beams: steadier focus, faster volume scans, and simpler stereoscopic imaging, De Koninck, Yves, McCarthy, Nathalie, Castonguay, Annie, Cottet, Martin, Theriault, Gabrielle, Frontiers in Cellular Neuroscience, 2014, 10.3389/fncel.2014.00139
  • Microscopie à deux photons pour l’imagerie cellulaire fonctionnelle : avantages et enjeux ou Un photon c’est bien… mais deux c’est mieux !, , Médecine/sciences, 2006, 10.1051/MEDSCI/20062210837
  • Gain control of firing rate by shunting inhibition: Roles of synaptic noise and dendritic saturation, , Proceedings of the National Academy of Sciences of the United States of America, 2003, 10.1073/pnas.0337591100
  • Remote local photoactivation of morphine produces analgesia without opioid‐related adverse effects, Francisco Ciruela, Víctor Fernández‐Dueñas, Amadeu Llebaria, Jordi Hernando, Yves De Koninck, Jesús Giraldo, Gisela Cabré, Kristoffer Sahlholm, Ester Aso, Joan Font, Marc López‐Cano, British Journal of Pharmacology, 2023, 10.1111/bph.15645
  • A multimodal micro-optrode combining field and single unit recording, multispectral detection and photolabeling capabilities., Vallee, Real, Lavertu, Guillaume, Juneau-Fecteau, Alexandre, Dufour-Beausejour, Sophie, Dufour, Suzie, Deschenes, Martin, De Koninck, Yves, Calakos, Nicole, PloS one, 2013, 10.1371/journal.pone.0057703
  • Enhancing neuronal chloride extrusion rescues alpha 2/alpha 3 GABA(A)-mediated analgesia in neuropathic pain, De Koninck, Yves, Ribeiro-da-Silva, Alfredo, Doyon, Nicolas, Gagnon, Martin, Kianicka, Irenej, Boudreau, Dominic, Girard, Alexandre A., Labrecque, Simon, Plasencia-Fernandez, Isabel, Bachand, Karine, Ferrini, Francesco, Godin, Antoine G., Lorenzo, Louis-Etienne, Nature Communications, 2020, 10.1038/S41467-019-14154-6
  • Transition to chronic pain: opportunities for novel therapeutics, Robert H. Dworkin, Tony L. Yaksh, Tor D. Wager, Gregory W. Terman, Kathleen A. Sluka, Neil Schechter, Linda Porter, Jon D. Levine, Annemieke Kavelaars, Joel Katz, Ru-Rong Ji, Robert R. Edwards, Yves De Koninck, Jan F. Chambers, Jacqueline Bresnahan, Allan I. Basbaum, Theodore J. Price, Nature Reviews Neuroscience, 2018, 10.1038/s41583-018-0012-5
  • Translational control of nociception via 4E-binding protein 1., Sonenberg, Nahum, Mogil, Jeffrey S, Cervero, Fernando, De Koninck, Yves, Ribeiro-da-Silva, Alfredo, Martin, Loren, Salter, Eric W, Perez-Sanchez, Jimena, Alain, Tommy, Pitcher, Mark H, Jafarnejad, Seyed Mehdi, Pawlowski, Sophie Anne, Gkogkas, Christos G, Sorge, Robert E, Bonin, Robert P, Khoutorsky, Arkady, eLife, 2015, 10.7554/eLife.12002
  • Adaptive movement compensation for in vivo imaging of fast cellular dynamics within a moving tissue, , PLoS ONE, 2011, 10.1371/journal.pone.0019928
  • Enhanced resolution in two-photon imaging using a TM01 laser beam at a dielectric interface, De Koninck, Y., Piché, M., Dehez, H., Optics Letters, 2009, 10.1364/OL.34.003601
  • Resolution enhancement in confocal microscopy using Bessel-Gauss beams., , Optics express, 2017, 10.1364/oe.25.002162
  • Revealing protein oligomerization and densities in situ using spatial intensity distribution analysis, , Proceedings of the National Academy of Sciences of the United States of America, 2011, 10.1073/pnas.1018658108
  • An Indigenous Lens on Priorities for the Canadian Brain Research Strategy, Illes, J., Young, J.Z., Menard, C., Marra, C., Lawson, A., De Koninck, Y., Mushquash, C.J., Gabel, C., King, M., Perreault, M.L., Canadian Journal of Neurological Sciences, 2021, 10.1017/cjn.2021.501
  • Central neuroglial interactions in the pathophysiology of neuropathic pain, De Koninck, Y., Zhang, J., Functional Pain Syndromes: Presentation and Pathophysiology, 2015
  • Dendritic spine viscoelasticity and soft-glassy nature: Balancing dynamic remodeling with structural stability, , Biophysical Journal, 2007, 10.1529/biophysj.106.092361
  • Substance P released endogenously by high-intensity sensory stimulation potentiates purinergic inhibition of nociceptive dorsal horn neurons induced by peripheral vibration, , Neuroscience Letters, 1994, 10.1016/0304-3940(94)90887-7
  • We need to talk: The urgent conversation on chronic pain, mental health, prescribing patterns and the opioid crisis, Quinn, Patrick D., Stinson, Jennifer, De Koninck, Yves, Scaini, Simona, Campbell, Fiona, Groenewald, Cornelius B., Battaglia, Marco, Journal of Psychopharmacology, 2023, 10.1177/02698811221144635
  • Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice., , Scientific reports, 2017, 10.1038/srep41432
  • A Low-Power Current-Reuse Analog Front-End for High-Density Neural Recording Implants., , IEEE transactions on biomedical circuits and systems, 2018, 10.1109/tbcas.2018.2805278
  • Rapid Mechanically Controlled Rewiring of Neuronal Circuits, Gruetter, Peter, De Koninck, Yves, Fournier, Alyson E., Barrett, Christopher J., Miyahara, Yoichi, Sanz, Ricardo, Goulet-Hanssens, Alexis, Boudreau, Dominic, Mori, Megumi, Lopez-Ayon, G. Monserratt, Magdesian, Margaret H., Journal of Neuroscience, 2016, 10.1523/JNEUROSCI.1667-15.2016
  • Automated method for the segmentation and morphometry of nerve fibers in large-scale CARS images of spinal cord tissue, Cote, Daniel C., De Koninck, Yves, Laffray, Sophie, Daradich, Amy, Belanger, Erik, Dupont-Therrien, Olivier, Begin, Steve, Biomedical Optics Express, 2014, 10.1364/BOE.5.004145
  • Morphology and neurokinin 1 receptor expression of spinothalamic lamina I neurons in the rat spinal cord, , Journal of Comparative Neurology, 2005, 10.1002/cne.20675
  • Cortical interneuron-mediated inhibition delays the onset of amyotrophic lateral sclerosis, Woodin, Melanie A., Kim, Jun Chul, Robertson, Janice, Zinman, Lorne, Keith, Julia, De Koninck, Yves, Cote, Daniel, Gasecka, Alicja, Keramidis, Iason, Garand, Danielle, Yang, Jy Wei, Bedard, Simon, Pressey, Jessica C., Liang, Xinyi, Dargaei, Zahra, Place, Kara M., Aqrabawi, Afif J., Khademullah, C. Sahara, Brain, 2020, 10.1093/BRAIN/AWAA034
  • Developmental Potential and Plasticity of Olfactory Epithelium Stem Cells Revealed by Heterotopic Grafting in the Adult Brain, Saghatelyan, Armen, de Koninck, Yves, Bressan, Cedric, Siri, Tiziano, Li, Qian, Stem Cell Reports, 2020, 10.1016/J.STEMCR.2020.03.008
  • Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts, , Proceedings of the National Academy of Sciences of the United States of America, 1992, 10.1073/pnas.89.11.5073
  • Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition, De Koninck, Yves, Prescott, Steven A., Vinay, Laurent, Doyon, Nicolas, Neuron, 2016, 10.1016/j.neuron.2016.02.030
  • A Wireless Optogenetic Headstage with Multichannel Electrophysiological Recording Capability, Gosselin, Benoit, de Koninck, Yves, Bories, Cyril, Fortier, Paul, Bareil, Paul Brule, Neron, Jean-Luc, LeChasseur, Yoan, Camaro, Charles-Olivier Dufresne, Ameli, Reza, Kisomi, Alireza Avakh, Gagnon-Turcotte, Gabriel, Sensors, 2015, 10.3390/s150922776
  • Spatial Intensity Distribution Analysis (SpIDA): A New Tool for Receptor Tyrosine Kinase Activation and Transactivation Quantification, Beaulieu, Jean-Martin, Wiseman, Paul W., De Koninck, Yves, Godin, Antoine G., Swift, Jody L., Barbeau, Annie, Methods in Cell Biology, 2013, 10.1016/B978-0-12-408143-7.00001-3
  • QRS widening and QT prolongation under bupropion: A unique cardiac electrophysiological profile, , Fundamental and Clinical Pharmacology, 2012, 10.1111/j.1472-8206.2011.00953.x
  • Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation, , Proceedings of the National Academy of Sciences of the United States of America, 1991
  • Spatial intensity distribution analysis (SpIDA) a method to probe membrane receptor organization in intact cells, Wiseman, P.W., De Koninck, Y., Potvin-Trottier, L., Rappaz, B., Godin, A.G., Cell Membrane Nanodomains: From Biochemistry to Nanoscopy, 2014, 10.1201/b17634
  • Destruction of polymer growth substrates for cell cultures in two-photon microscopy, , Journal of Microscopy, 2005, 10.1111/j.1365-2818.2005.01523.x
  • Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes, Salter, Michael W., Prescott, Steven A., De Koninck, Yves, Muley, Milind M., Gauthier, Cedric, Lee, Kwan Yeop, Lorenzo, Louis-Etienne, Mapplebeck, Josiane C. S., Cell Reports, 2019, 10.1016/J.CELREP.2019.06.059
  • Enhanced harm detection following maternal separation: Transgenerational transmission and reversibility by inhaled amiloride, Yves De Koninck, Francesca R. D’Amato, Antoine G. Godin, Jasmin Deguire, Louis-Etienne Lorenzo, Orlane Rossignol, Marco Battaglia, Science Advances, 2023, 10.1126/sciadv.adi8750
  • Quantitative analysis of substance P-immunoreactive boutons on physiologically characterized dorsal horn neurons in the cat lumbar spinal cord, , Journal of Comparative Neurology, 1996, 10.1002/(SICI)1096-9861(19961202)376:1<45::AID-CNE3>3.0.CO;2-O
  • BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain, , Nature, 2005, 10.1038/nature04223
  • Pyramidal neurons switch from integrators in vitro to resonators under in vivo-like conditions, , Journal of Neurophysiology, 2008, 10.1152/jn.90634.2008
  • An ambiguous fast synapse: A new twist in the tale of two transmitters, , Nature Neuroscience, 1999, 10.1038/6296
  • ATP‐Sensitive K+ channels mediate an IPSP in dorsal horn neurones elicited by sensory stimulation, Henry, J.L., De Koninck, Y., Salter, M.W., Synapse, 1992, 10.1002/syn.890110306
  • A Female-Specific Role for Calcitonin Gene-Related Peptide (CGRP) in Rodent Pain Models, Price, T.J., Dussor, G., De Koninck, Y., Akopian, A.N., Garcia-Martinez, L.F., Feldhaus, A.L., Ferrini, F., Driskill, C., Mejia, G.L., He, L., David, E.T., Lorenzo, L.-E., Papalampropoulou-Tsiridou, M., Kume, M., Plasencia-Fernandez, I., Paige, C., Journal of Neuroscience, 2022, 10.1523/JNEUROSCI.1137-21.2022
  • Loss of presynaptic and postsynaptic structures is accompanied by compensatory increase in action potential-dependent synaptic input to layer V neocortical pyramidal neurons in aged rats, , Journal of Neuroscience, 2000
  • Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain, , Molecular Pain, 2007, 10.1186/1744-8069-3-27
  • Region-specific developmental specialization of GABA-glycine cosynapses in laminas I-II of the rat spinal dorsal horn, , Journal of Neuroscience, 2001
  • Properties of K+ channels linked to GABA(B) receptors activated by endogenously released GABA, De Koninck, Y., Mody, I., Pharmacology Communications, 1996
  • Epidural optogenetics for controlled analgesia, De Koninck, Yves, Cote, Daniel C., Boulanger, Marie-Eve, Gasecka, Alicja, Desrochers-Couture, Mireille, Wang, Feng, Bonin, Robert P., Molecular Pain, 2016, 10.1177/1744806916629051
  • Inhibitory coupling between inhibitory interneurons in the spinal cord dorsal horn, , Molecular Pain, 2009, 10.1186/1744-8069-5-24
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  • Characterization of synaptically elicited GABAB responses using patch‐clamp recordings in rat hippocampal slices., Mody, I., De Koninck, Y., Otis, T.S., The Journal of Physiology, 1993, 10.1113/jphysiol.1993.sp019600
  • α5GABAA Receptors Mediate Tonic Inhibition in the Spinal Cord Dorsal Horn and Contribute to the Resolution Of Hyperalgesia., , Journal of neuroscience research, 2016, 10.1002/jnr.23981
  • Noise analysis of miniature IPSCs in adult rat brain slices: Properties and modulation of synaptic GABA(A) receptor channels, , Journal of Neurophysiology, 1994
  • Two-photon excitation fluorescence microscopy with a high depth of field using an axicon, , Applied Optics, 2006, 10.1364/AO.45.009246
  • Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat, , Journal of Physiology, 2002, 10.1113/jphysiol.2001.013437
  • Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer's disease., , Aging, 2017, 10.18632/aging.101239
  • KCC2 : nouvelle cible thérapeutique pour le traitement de pathologies neurologiques, , Médecine/sciences, 2014, 10.1051/MEDSCI/20143005013
  • GABA(B) receptors are the first target of released GABA at lamina I inhibitory synapses in the adult rat spinal cord, De Koninck, Y., Chéry, N., Journal of Neurophysiology, 2000, 10.1152/jn.2000.84.2.1006
  • Prolonged GABAA‐mediated inhibition following single hair afferent input to single spinal dorsal horn neurones in cats., Henry, J.L., De Koninck, Y., The Journal of Physiology, 1994, 10.1113/jphysiol.1994.sp020114
  • Nonlinear interaction between shunting and adaptation controls a switch between integration and coincidence detection in pyramidal neurons, , Journal of Neuroscience, 2006, 10.1523/JNEUROSCI.1388-06.2006
  • Reply to The small molecule CLP257 does not modify activity of the K+–Cl− co-transporter KCC2 but does potentiate GABAA receptor activity, Yves De Koninck, Robert P Bonin, Annie Castonguay, Antoine G Godin, Louis-Etienne Lorenzo, Isabel Plasencia-Fernández, Jimena Perez-Sanchez, Marc J Bergeron, Martin Gagnon, Nature Medicine, 2017, 10.1038/nm.4449
  • High-DR CMOS Fluorescence Biosensor With Extended Counting ADC and Noise Cancellation, Gosselin, Benoit, De Koninck, Yves, Martel, Sylvain, Khiarak, Mehdi Noormohammadi, IEEE Transactions on Circuits and Systems I: Regular Papers, 2019, 10.1109/TCSI.2019.2895652
  • Junctional versus Extrajunctional Glycine and GABA A Receptor-Mediated IPSCs in Identified Lamina I Neurons of the Adult Rat Spinal Cord, , The Journal of Neuroscience, 1999, 10.1523/JNEUROSCI.19-17-07342.1999
  • Restoring ionotropic inhibition as an analgesic strategy, De Koninck, Yves, Bonin, Robert P., Neuroscience Letters, 2013, 10.1016/j.neulet.2013.09.047
  • Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain., , Science advances, 2019, 10.1126/sciadv.aav9946
  • An inhibitory postsynaptic potential in spinal nociceptive neurones is mediated by adenosine through activation of ATP‐sensitive K+ channels, Henry, J.L., De Koninck, Y., Salter, M.W., Drug Development Research, 1993, 10.1002/ddr.430280342
  • Resolution enhancement in laser scanning microscopy with deconvolution switching laser modes (D-SLAM)., , Optics express, 2018, 10.1364/oe.26.024881
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  • Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells, , Proceedings of the National Academy of Sciences of the United States of America, 2011, 10.1073/pnas.1018280108
  • Live animal myelin histomorphometry of the spinal cord with video-rate multimodal nonlinear microendoscopy., , Journal of biomedical optics, 2012
  • Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis, , PLoS Computational Biology, 2011, 10.1371/journal.pcbi.1002149
  • P2X 4 receptors influence inflammasome activation after spinal cord injury, Lacroix, S., Keane, R.W., De Koninck, Y., Dalton Dietrich, W., Pineau, I., Yurcisin, G., Bastien, D., de Rivero Vaccari, J.P., Journal of Neuroscience, 2012, 10.1523/JNEUROSCI.4930-11.2012
  • A novel assessment of fine-motor function reveals early hindlimb and detectable forelimb deficits in an experimental model of ALS, De Koninck, Yves, Khademullah, C. Sahara, Scientific Reports, 2022, 10.1038/S41598-022-20333-1
  • Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain, , 2003, 10.1038/nature01868
  • Development and Implementation of a Registry of Patients Attending Multidisciplinary Pain Treatment Clinics: The Quebec Pain Registry., , Pain research & management, 2017, 10.1155/2017/8123812
  • Morphological and functional characterization of cholinergic interneurons in the dorsal horn of the mouse spinal cord, , Journal of Comparative Neurology, 2011, 10.1002/cne.22668
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  • Probing pain pathways with light., , Neuroscience, 2016, 10.1016/j.neuroscience.2016.09.035
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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Louison Brochoire - Doctorat - En cours
  • Susana Soares Lima - Doctorat - En cours
  • Mohamad Feshki - Doctorat - En cours
  • Einer Munoz Pino - Doctorat - En cours
  • Farida Hamidou Farida Hamidou - Maîtrise avec mémoire - En cours
  • Andrée-Anne Verreault - Maîtrise avec mémoire - En cours
  • Charline Sahara Khademullah-Coskun - Post-doctorat - En cours
  • Philippe Léonard-Dufour - Maîtrise avec mémoire - En cours
  • Dominique Isabel - Maîtrise avec mémoire - En cours
  • Samuel Ferland - Doctorat - En cours
  • Yasin Esmaeilou - Doctorat - En cours
  • Félix Desrosiers - Doctorat - En cours
  • Joshua Katambwe - Maîtrise avec mémoire - En cours
  • Émilie Chamma - Maîtrise avec mémoire - 2013/09
  • Louis Thibon - Doctorat - 2019/01
  • Mehdi Noormohammadi Khiarak - Doctorat - 2019/01
  • Melina Papalampropoulou-Tsiridou - Doctorat - 2021/05
  • Isabel Plasencia Fernandez - Doctorat - 2021/09
  • Iason Keramidis - Doctorat - 2022/09
  • Julien Bourbonnais - Maîtrise avec mémoire - 2023/01
  • Reza Hazrati - Doctorat - 2023/05
  • Axelle Dovonou - Doctorat - 2024/01
*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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